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Martin Cranage

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Living Beings

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Simian Acquired Immunodeficiency Syndrome

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Carolina Herrera; Ian McGowan; Peter Anton; Martin Cranage; Robin J Shattock
Colorectal microbicide design: triple combinations of reverse transcriptase inhibitors are optimal against HIV-1 in tissue explants.
Martin Cranage; Carol A Fraser; Alethea Cope; Paul F McKay; Michael S Seaman; Tom Cole; A Nasir Mahmoud; Joanna Hall; Elaine Giles; Gerald Voss; Mark Page; Neil Almond; Robin J Shattock
Antibody responses after intravaginal immunisation with trimeric HIV-1 CN54 clade C gp140 in Carbopol gel are augmented by systemic priming or boosting with an adjuvanted formulation.
Neil Berry; Carolina Herrera; Martin Cranage
Detection, quantification, and characterisation of HIV/SIV.

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2011: Carolina Herrera; Ian McGowan; Peter Anton; Martin Cranage; Robin J Shattock
Colorectal microbicide design: triple combinations of reverse transcriptase inhibitors are optimal against HIV-1 in tissue explants.
AIDS (London, England) 2011;25(16):1971-9.
2011: Martin Cranage; Carol A Fraser; Alethea Cope; Paul F McKay; Michael S Seaman; Tom Cole; A Nasir Mahmoud; Joanna Hall; Elaine Giles; Gerald Voss; Mark Page; Neil Almond; Robin J Shattock
Antibody responses after intravaginal immunisation with trimeric HIV-1 CN54 clade C gp140 in Carbopol gel are augmented by systemic priming or boosting with an adjuvanted formulation.
Vaccine 2011;29(7):1421-30.
2011: Neil Berry; Carolina Herrera; Martin Cranage
Detection, quantification, and characterisation of HIV/SIV.
Methods in molecular biology (Clifton, N.J.) 2011;665():133-60.
2010: Martin Cranage; C A Fraser; Z Stevens; J Huting; M Chang; S A Jeffs; M S Seaman; A Cope; T Cole; Robin J Shattock
Repeated vaginal administration of trimeric HIV-1 clade C gp140 induces serum and mucosal antibody responses.
Mucosal immunology 2010;3(1):57-68.
2009: Carolina Herrera; Martin Cranage; Ian McGowan; Peter A Anton; Robin J Shattock
Reverse transcriptase inhibitors as potential colorectal microbicides.
Antimicrobial agents and chemotherapy 2009;53(5):1797-807.
2008: Martin Cranage; Sally Sharpe; Carolina Herrera; Alethea Cope; Mike Dennis; Neil Berry; Claire Ham; Jonathan Luke Heeney; Abdel Naser La Rezk; Angela D M Kashuba; Peter A Anton; Ian McGowan; Robin J Shattock
Prevention of SIV rectal transmission and priming of T cell responses in macaques after local pre-exposure application of tenofovir gel.
PLoS medicine 2008;5(8):e157; discussion e157.
2005: Martin Cranage; Geraldine Taylor
Carriers for the delivery of a vaccine against respiratory syncytial virus.
Expert opinion on biological therapy 2005;5(7):939-52.
2004: Sally A Sharpe; Alethea Cope; Stuart Dowall; Neil Berry; Claire Ham; Jonathan Luke Heeney; Donna Hopkins; Linda Easterbrook; Mike Dennis; Neil Almond; Martin Cranage
Macaques infected long-term with attenuated simian immunodeficiency virus (SIVmac) remain resistant to wild-type challenge, despite declining cytotoxic T lymphocyte responses to an immunodominant epitope.
The Journal of general virology 2004;85(Pt 9):2591-602.
2004: Julia A Tree; Gary Bembridge; Sam Hou; Geraldine Taylor; Elizabeth Fashola-Stone; José Melero; Martin Cranage
An assessment of different DNA delivery systems for protection against respiratory syncytial virus infection in the murine model: gene-gun delivery induces IgG in the lung.
Vaccine 2004;22(19):2438-43.
2003: Sally A Sharpe; Tomás Hanke; Anne Tinsley-Bown; Mike Dennis; Stuart Dowall; Andrew McMichael; Martin Cranage
Mucosal immunization with PLGA-microencapsulated DNA primes a SIV-specific CTL response revealed by boosting with cognate recombinant modified vaccinia virus Ankara.
Virology 2003;313(1):13-21.
2003: Natasha Polyanskaya; Sally A Sharpe; Nicola Cook; Sharon Leech; Martin Cranage
Infection of macaques with simian immunodeficiency virus induces a species-specific antibody response to major histocompatibility complex class I and class II molecules.
The Journal of general virology 2003;84(Pt 7):1671-6.
2002: Koert J Stittelaar; Rob A Gruters; Martin Schutten; Carel A van Baalen; Geert van Amerongen; Martin Cranage; Peter Liljeström; Gerd Sutter; Albert D M E Osterhaus
Comparison of the efficacy of early versus late viral proteins in vaccination against SIV.
Vaccine 2002;20(23-24):2921-7.
2002: Bo Peng; Rebecca Voltan; Lulu Lim; Yvette Edghill Spano; Sanjay Phogat; Dimiter S Dimitrov; Kamalpreet Arora; Michel Leno; Soe Than; ruth woodward; Phillip D Markham; Martin Cranage; Marjorie Robert-Guroff
Rhesus macaque resistance to mucosal simian immunodeficiency virus infection is associated with a postentry block in viral replication.
Journal of virology 2002;76(12):6016-26.
2002: Sally A Sharpe; Anthony R Fooks; John Lee; Kevin Hayes; Christopher Clegg; Martin Cranage
Single oral immunization with replication deficient recombinant adenovirus elicits long-lived transgene-specific cellular and humoral immune responses.
Virology 2002;293(2):210-6.
2001: Sally A Sharpe; Brigitte E Beer; G Hall; Mike Dennis; Stephen Norley; Martin Cranage
Analysis of SIV-specific CTL in the rhesus macaque model of AIDS: the use of simian fibroblasts as an alternative source of target cells for chromium release assays.
Journal of immunological methods 2001;258(1-2):137-40.
2001: Sally A Sharpe; Natasha Polyanskaya; Mike Dennis; Gerd Sutter; Tomás Hanke; V Erfle; Vanessa M Hirsch; Martin Cranage
Induction of simian immunodeficiency virus (SIV)-specific CTL in rhesus macaques by vaccination with modified vaccinia virus Ankara expressing SIV transgenes: influence of pre-existing anti-vector immunity.
The Journal of general virology 2001;82(Pt 9):2215-23.
2001: Peter Ten Haaft; Neil Almond; Gunnel Biberfeld; Aurelio Aurelio Cafaro; Martin Cranage; Barbara Ensoli; Gerhard Hunsmann; Natasha Polyanskaya; Christiane Stahl-Hennig; R Thortensson; Fausto Titti; Jonathan Luke Heeney
Comparison of early plasma RNA loads in different macaque species and the impact of different routes of exposure on SIV/SHIV infection.
Journal of medical primatology 2001;30(4):207-14.
2001: Donatella R M Negri; Silvia Baroncelli; Zuleika Michelini; Iole Macchia; Roberto Belli; Stefania Catone; F Incitti; Peter Ten Haaft; Franco Corrias; Martin Cranage; Natasha Polyanskaya; Stephen Norley; Jonathan Luke Heeney; Paola Verani; Fausto Titti
Effect of vaccination with recombinant modified vaccinia virus Ankara expressing structural and regulatory genes of SIV(macJ5) on the kinetics of SIV replication in cynomolgus monkeys.
Journal of medical primatology 2001;30(4):197-206.
2001: L Jean Patterson; Frank A Robey; A Muck; K Van Remoortere; Kristine Aldrich; Ersell Richardson; W Gregory Alvord; Phillip D Markham; Martin Cranage; Marjorie Robert-Guroff
A conformational C4 peptide polymer vaccine coupled with live recombinant vector priming is immunogenic but does not protect against rectal SIV challenge.
AIDS research and human retroviruses 2001;17(9):837-49.
2001: Natasha Polyanskaya; Lesley A Bergmeier; Sally A Sharpe; Nicola Cook; Sharon Leech; G Hall; Mike Dennis; Peter Ten Haaft; Jonathan Luke Heeney; F Manca; Thomas Lehner; Martin Cranage
Mucosal exposure to subinfectious doses of SIV primes gut-associated antibody-secreting cells and T cells: lack of enhancement by nonneutralizing antibody.
Virology 2001;279(2):527-38.
2000: Leonid Margolis; Svetlana Glushakova; Claire Chougnet; G Shearer; Phillip Markham; Marjorie Robert-Guroff; R Benveniste; Christopher J Miller; Martin Cranage; Vanessa M Hirsch; Genoveffa Franchini
Replication of simian immunodeficiency virus (SIV) in ex vivo lymph nodes as a means to assess susceptibility of macaques in vivo.
Virology 2000;275(2):391-7.
2000: Thomas Lehner; E Mitchell; Lesley A Bergmeier; M Singh; R Spallek; Martin Cranage; G Hall; M Dennis; Francios VILLINGER; Yufei Wang
The role of gammadelta T cells in generating antiviral factors and beta-chemokines in protection against mucosal simian immunodeficiency virus infection.
European journal of immunology 2000;30(8):2245-56.
2000: Thomas Lehner; Yufei Wang; Martin Cranage; L Tao; E Mitchell; CA Bravery; C Doyle; K Pratt; G Hall; M Dennis; L Villinger; Lesley A Bergmeier
Up-regulation of beta-chemokines and down-modulation of CCR5 co-receptors inhibit simian immunodeficiency virus transmission in non-human primates.
Immunology 2000;99(4):569-77.
2000: Anthony R Fooks; Sally A Sharpe; J A Shallcross; J C S Clegg; Martin Cranage
Induction of immunity using oral DNA vaccines expressing the measles virus nucleocapsid protein.
Developments in biologicals 2000;104():65-71.
1999: C B Bruce; A Akrigg; Sally A Sharpe; Tomás Hanke; G W Wilkinson; Martin Cranage
Replication-deficient recombinant adenoviruses expressing the human immunodeficiency virus Env antigen can induce both humoral and CTL immune responses in mice.
The Journal of general virology 1999;80 ( Pt 10)():2621-8.
1999: Tomás Hanke; R V Samuel; Tom J Blanchard; V C Neumann; T M Allen; Jonathan Boyson; Sally A Sharpe; Nicola Cook; Geoffrey L Smith; David Ian Watkins; Martin Cranage; Andrew J McMichael
Effective induction of simian immunodeficiency virus-specific cytotoxic T lymphocytes in macaques by using a multiepitope gene and DNA prime-modified vaccinia virus Ankara boost vaccination regimen.
Journal of virology 1999;73(9):7524-32.
1999: Thomas Lehner; Yufei Wang; L Ping; Lesley A Bergmeier; E Mitchell; Martin Cranage; G Hall; M Dennis; Nicola Cook; C Doyle; I Jones
The effect of route of immunization on mucosal immunity and protection.
The Journal of infectious diseases 1999;179 Suppl 3():S489-92.
1998: Charlotta Nilsson; Barbro Mäkitalo; Rigmor Thorstensson; Stephen Norley; Doris Binninger-Schinzel; Martin Cranage; Erling Rud; Gunnel Biberfeld; P Putkonen
Live attenuated simian immunodeficiency virus (SIV)mac in macaques can induce protection against mucosal infection with SIVsm.
AIDS (London, England) 1998;12(17):2261-70.
1998: Martin Cranage; Sally A Sharpe; AM Whatmore; Natasha Polyanskaya; Stephen Norley; Nicola Cook; Sharon Leech; Mike J Dennis; Graham A Hall
In vivo resistance to simian immunodeficiency virus superinfection depends on attenuated virus dose.
The Journal of general virology 1998;79 ( Pt 8)():1935-44.
1998: Lesley A Bergmeier; E A Mitchell; G Hall; Martin Cranage; Nicola Cook; M Dennis; Thomas Lehner
Antibody-secreting cells specific for simian immunodeficiency virus antigens in lymphoid and mucosal tissues of immunized macaques.
AIDS (London, England) 1998;12(10):1139-47.
1998: J Benson; Claire Chougnet; Marjorie Robert-Guroff; David Montefiori; Phillip Markham; G Shearer; Robert C Gallo; Martin Cranage; E Paoletti; K Limbach; David Venzon; Jim Tartaglia; Genoveffa Franchini
Recombinant vaccine-induced protection against the highly pathogenic simian immunodeficiency virus SIV(mac251): dependence on route of challenge exposure.
Journal of virology 1998;72(5):4170-82.
1998: J D Wilson; Martin Cranage; Nicola Cook; Sharon Leech; Andrew J McMichael; Margaret F C Callan
Evidence for the persistence of monoclonal expansions of CD8+ T cells following primary simian immunodeficiency virus infection.
European journal of immunology 1998;28(4):1172-80.
1998: Thomas Lehner; Yufei Wang; Martin Cranage; Lesley A Bergmeier; E Mitchell; L Tao; G Hall; M Dennis; Nicola Cook; I Jones; C Doyle
Protective mucosal immunity elicited by targeted lymph node immunization with a subunit SIV envelope and core vaccine in macaques.
Developments in biological standardization 1998;92():225-35.
1997: Sally A Sharpe; AM Whatmore; Graham A Hall; Martin Cranage
Macaques infected with attenuated simian immunodeficiency virus resist superinfection with virulence-revertant virus.
The Journal of general virology 1997;78 ( Pt 8)():1923-7.
1997: Natasha Polyanskaya; Sally A Sharpe; Nicola Cook; Sharon Leech; J Banks; Mike Dennis; G Hall; J Stott; Martin Cranage
Anti-major histocompatibility complex antibody responses to simian B cells do not protect macaques against SIVmac infection.
AIDS research and human retroviruses 1997;13(11):923-31.
1997: Martin Cranage; AM Whatmore; Sally A Sharpe; Nicola Cook; Natasha Polyanskaya; Sharon Leech; J D Smith; Erling Rud; Mike J Dennis; Graham A Hall
Macaques infected with live attenuated SIVmac are protected against superinfection via the rectal mucosa.
Virology 1997;229(1):143-54.
1997: Neil Almond; Terry Corcoran; Robin Hull; Kenneth Barry Walker; Jane Rose; Rebecca Sangster; K Silvera; Peter Silvera; Martin Cranage; Erling Rud; E Jim Stott
Mechanisms of protection induced by attenuated simian immunodeficiency virus. IV. Protection against challenge with virus grown in autologous simian cells.
Journal of medical primatology 1997;26(1-2):34-43.
1996: Thomas Lehner; Yufei Wang; Martin Cranage; Lesley A Bergmeier; E Mitchell; L Tao; G Hall; M Dennis; Nicola Cook; R Brookes; Linda S Klavinskis; I Jones; C Doyle; R Ward
Protective mucosal immunity elicited by targeted iliac lymph node immunization with a subunit SIV envelope and core vaccine in macaques.
Nature medicine 1996;2(7):767-75.
1995: L A Ashworth; Graham A Hall; Sally A Sharpe; Mike J Dennis; C Thornton; R W Cook; H Smith; Martin Cranage
Constitutive expression of major histocompatibility complex class II antigens on monocytes and B cells correlates with disease in simian immunodeficiency virus-infected rhesus macaques.
The Journal of infectious diseases 1995;172(5):1261-7.
1995: A Gallimore; Martin Cranage; Nicola Cook; Neil Almond; J Bootman; Erling Rud; Peter Silvera; M Dennis; Terry Corcoran; Jim Stott
Early suppression of SIV replication by CD8+ nef-specific cytotoxic T cells in vaccinated macaques.
Nature medicine 1995;1(11):1167-73.
1995: EG Hulskotte; AM Geretti; KH Siebelink; Geert van Amerongen; Martin Cranage; Erling Rud; Stephen Norley; P de Vries; A D Osterhaus
Vaccine-induced virus-neutralizing antibodies and cytotoxic T cells do not protect macaques from experimental infection with simian immunodeficiency virus SIVmac32H (J5).
Journal of virology 1995;69(10):6289-96.
1995: A M Whatmore; Nicola Cook; Graham A Hall; Sally A Sharpe; Erling Rud; Martin Cranage
Repair and evolution of nef in vivo modulates simian immunodeficiency virus virulence.
Journal of virology 1995;69(8):5117-23.
1995: Norman L Letvin; J Li; M Halloran; Martin Cranage; Erling Rud; Joseph Sodroski
Prior infection with a nonpathogenic chimeric simian-human immunodeficiency virus does not efficiently protect macaques against challenge with simian immunodeficiency virus.
Journal of virology 1995;69(7):4569-71.
1995: Martin Cranage; B W McBride; Erling Rud
The simian immunodeficiency virus transmembrane protein is poorly immunogenic in inactivated virus vaccine.
Vaccine 1995;13(10):895-900.
1995: Neil Almond; K Kent; Martin Cranage; Erling Rud; B Clarke; E Jim Stott
Protection by attenuated simian immunodeficiency virus in macaques against challenge with virus-infected cells.
Lancet 1995;345(8961):1342-4.
1995: E Race; P Frezza; D M Stephens; D Davis; Natasha Polyanskaya; Martin Cranage; J S Oxford
An experimental chemically inactivated HIV-1 vaccine induces antibodies that neutralize homologous and heterologous viruses.
Vaccine 1995;13(1):54-60.
1994: Henk Niphuis; R H Dubbes; Peter Ten Haaft; W H Koornstra; Ronald E Bontrop; Martin Cranage; Jonathan Luke Heeney
Infectivity and virulence of cell-associated SIVmac after single passage in vivo.
AIDS (London, England) 1994;8(12):1730-1.
1994: Lesley A Bergmeier; J Walker; L Tao; Martin Cranage; Thomas Lehner
Antibodies to human and non-human primate cellular and culture medium components in macaques vaccinated with the simian immunodeficiency virus.
Immunology 1994;83(2):213-20.
1994: Jonathan Luke Heeney; Cecile Van Els; P de Vries; Peter Ten Haaft; Nel Otting; W Koornstra; J Boes; R Dubbes; Henk Niphuis; ME Dings; Martin Cranage; Stephen Norley; M Jonker; Ronald E Bontrop; A Osterhaus
Major histocompatibility complex class I-associated vaccine protection from simian immunodeficiency virus-infected peripheral blood cells.
The Journal of experimental medicine 1994;180(2):769-74.
1994: Erling Rud; Martin Cranage; J Yon; J Quirk; L Ogilvie; Nicola Cook; S Webster; M Dennis; B E Clarke
Molecular and biological characterization of simian immunodeficiency virus macaque strain 32H proviral clones containing nef size variants.
The Journal of general virology 1994;75 ( Pt 3)():529-43.
1993: A F Dean; M Montgomery; A Baskerville; R W Cook; Martin Cranage; Sally A Sharpe; Mike J Dennis; P J Luthert; S T Hou; P L Lantos
Different patterns of neuropathological disease in rhesus monkeys infected by simian immunodeficiency virus, and their relation to the humoral immune response.
Neuropathology and applied neurobiology 1993;19(4):336-45.
1993: X C Teng; L A Ashworth; Sally A Sharpe; Mike J Dennis; Martin Cranage
Lymphoproliferative responses in macaques immunized with inactivated SIV vaccine.
AIDS research and human retroviruses 1993;9(8):799-801.
1993: B W McBride; G Corthals; Erling Rud; K Kent; S Webster; Nicola Cook; Martin Cranage
Comparison of serum antibody reactivities to a conformational and to linear antigenic sites in the external envelope glycoprotein of simian immunodeficiency virus (SIVmac) induced by infection and vaccination.
The Journal of general virology 1993;74 ( Pt 6)():1033-41.
1993: P Putkonen; Charlotta Nilsson; K Hild; R Benthin; Martin Cranage; A M Aubertin; Gunnel Biberfeld
Whole inactivated SIV vaccine grown on human cells fails to protect against homologous SIV grown on simian cells.
Journal of medical primatology 1993;22(2-3):100-3.
1993: Martin Cranage; Natasha Polyanskaya; B McBride; Nicola Cook; L A Ashworth; M Dennis; A Baskerville; P J Greenaway; Terry Corcoran; P Kitchin
Studies on the specificity of the vaccine effect elicited by inactivated simian immunodeficiency virus.
AIDS research and human retroviruses 1993;9(1):13-22.
1992: Martin Cranage; Jim Stott; K Mills; T Ashworth; F Taffs; G Farrar; L Chan; M Dennis; P Putkonen; G Biberfeld
Vaccine studies with the 32H reisolate of SIVmac251: an overview.
AIDS research and human retroviruses 1992;8(8):1479-81.
1992: A Baskerville; R W Cook; Mike J Dennis; Martin Cranage; P J Greenaway
Pathological changes in the reproductive tract of male rhesus monkeys associated with age and simian AIDS.
Journal of comparative pathology 1992;107(1):49-57.
1992: A Baskerville; A D Ramsay; B J Addis; Mike J Dennis; R W Cook; Martin Cranage; P J Greenaway
Interstitial pneumonia in simian immunodeficiency virus infection.
The Journal of pathology 1992;167(2):241-7.
1992: Martin Cranage; L A Ashworth; P J Greenaway; M Murphey-Corb; R C Desrosiers
AIDS vaccine developments.
Nature 1992;355(6362):685-6.
1992: P Putkonen; Rigmor Thorstensson; Martin Cranage; Charlotta Nilsson; L Ghavamzadeh; Jan Albert; P Greenaway; Gunnel Biberfeld
A formalin inactivated whole SIVmac vaccine in Ribi adjuvant protects against homologous and heterologous SIV challenge.
Journal of medical primatology 1992;21(2-3):108-12.
1992: Martin Cranage; A Baskerville; L A Ashworth; M Dennis; Nicola Cook; Sally A Sharpe; G Farrar; Jane Rose; P A Kitchin; P J Greenaway
Intrarectal challenge of macaques vaccinated with formalin-inactivated simian immunodeficiency virus.
Lancet 1992;339(8788):273-4.
1992: Neil Almond; Adrian Jenkins; A Slade; A Heath; Martin Cranage; P Kitchin
Population sequence analysis of a simian immunodeficiency virus (32H reisolate of SIVmac251): a virus stock used for international vaccine studies.
AIDS research and human retroviruses 1992;8(1):77-88.
1992: Martin Cranage; Nicola Cook; E Jim Stott; R Cook; A Baskerville; P J Greenaway
Transmission studies with simian immunodeficiency virus of macaques; persistent infection of baboons.
Intervirology 1992;34(2):53-61.
1991: A Baskerville; A D Ramsay; G H Millward-Sadler; R W Cook; Martin Cranage; P J Greenaway
Chronic pancreatitis and biliary fibrosis associated with cryptosporidiosis in simian AIDS.
Journal of comparative pathology 1991;105(4):415-21.
1991: A D Ramsay; J Giddings; A Baskerville; Martin Cranage
Phenotypic analysis of malignant lymphoma in simian immunodeficiency virus infection using anti-human antibodies.
The Journal of pathology 1991;164(4):321-8.
1991: K A Kent; L Gritz; G Stallard; Martin Cranage; C Collignon; C Thiriart; Terry Corcoran; Peter Silvera; E Jim Stott
Production and of monoclonal antibodies to simian immunodeficiency virus envelope glycoproteins.
AIDS (London, England) 1991;5(7):829-36.
1991: A Baskerville; A B Dowsett; R W Cook; Mike J Dennis; Martin Cranage; P J Greenaway
Pneumocystis carinii pneumonia in simian immunodeficiency virus infection: immunohistological and scanning and transmission electron microscopical studies.
The Journal of pathology 1991;164(2):175-84.
1990: E Jim Stott; W L Chan; Kingston H G Mills; M Page; F Taffs; Martin Cranage; P Greenaway; P Kitchin
Preliminary report: protection of cynomolgus macaques against simian immunodeficiency virus by fixed infected-cell vaccine.
Lancet 1990;336(8730):1538-41.
1990: A Baskerville; A Ramsay; Martin Cranage; Nicola Cook; R W Cook; Mike J Dennis; P J Greenaway; P A Kitchin; E Jim Stott
Histopathological changes in simian immunodeficiency virus infection.
The Journal of pathology 1990;162(1):67-75.
1990: P A Kitchin; Neil Almond; Z Szotyori; C E Fromholc; L McAlpine; Peter Silvera; E Jim Stott; Martin Cranage; A Baskerville; G Schild
The use of the polymerase chain reaction for the detection of Simian immunodeficiency virus in experimentally infected macaques.
Journal of virological methods 1990;28(1):85-99.
1989: Martin Cranage; Neil Almond; Adrian Jenkins; P A Kitchin
Transmembrane protein of SIV.
Nature 1989;342(6248):349.