Benjamin Cravatt

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Cristina Benito; Rosa María Tolón; Ana Isabel Castillo; Lourdes Ruiz-Valdepeñas; José Antonio Martínez-Orgado; Francisco Javier Fernández-Sánchez; Carmen Vázquez; Benjamin F Cravatt; Julián Romero
β-Amyloid exacerbates inflammation in astrocytes lacking fatty acid amide hydrolase through a mechanism involving PPAR-α, PPAR-γ and TRPV1, but not CB(1) or CB(2) receptors.
Lamont Booker; Steven G Kinsey; Rehab A Abdullah; Jacqueline L Blankman; Jonathan Z Long; Cyrine Ezzili; Dale L Boger; Benjamin F Cravatt; Aron H Lichtman
The fatty acid amide hydrolase (FAAH) inhibitor PF-3845 acts in the nervous system to reverse LPS-induced tactile allodynia in mice.
Martin A Sticht; Jonathan Z Long; Erin M Rock; Cheryl L Limebeer; Raphael Mechoulam; Benjamin F Cravatt; Linda A Parker
Inhibition of monoacylglycerol lipase attenuates vomiting in Suncus murinus and 2-arachidonoyl glycerol attenuates nausea in rats.

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All Publications

2012: Cristina Benito; Rosa María Tolón; Ana Isabel Castillo; Lourdes Ruiz-Valdepeñas; José Antonio Martínez-Orgado; Francisco Javier Fernández-Sánchez; Carmen Vázquez; Benjamin F Cravatt; Julián Romero
β-Amyloid exacerbates inflammation in astrocytes lacking fatty acid amide hydrolase through a mechanism involving PPAR-α, PPAR-γ and TRPV1, but not CB(1) or CB(2) receptors.
British journal of pharmacology 2012;166(4):1474-89.
2012: Lamont Booker; Steven G Kinsey; Rehab A Abdullah; Jacqueline L Blankman; Jonathan Z Long; Cyrine Ezzili; Dale L Boger; Benjamin F Cravatt; Aron H Lichtman
The fatty acid amide hydrolase (FAAH) inhibitor PF-3845 acts in the nervous system to reverse LPS-induced tactile allodynia in mice.
British journal of pharmacology 2012;165(8):2485-96.
2012: Martin A Sticht; Jonathan Z Long; Erin M Rock; Cheryl L Limebeer; Raphael Mechoulam; Benjamin F Cravatt; Linda A Parker
Inhibition of monoacylglycerol lipase attenuates vomiting in Suncus murinus and 2-arachidonoyl glycerol attenuates nausea in rats.
British journal of pharmacology 2012;165(8):2425-35.
2012: Andrea M Zuhl; Justin T Mohr; Daniel A Bachovchin; Sherry Niessen; Ku-Lung Hsu; Jacob M Berlin; Maximilian Dochnahl; María P López-Alberca; Gregory C Fu; Benjamin F Cravatt
Competitive activity-based protein profiling identifies aza-β-lactams as a versatile chemotype for serine hydrolase inhibition.
Journal of the American Chemical Society 2012;134(11):5068-71.
2012: Jessica C Seeliger; Cynthia M Holsclaw; Michael W Schelle; Zsofia Botyanszki; Sarah A Gilmore; Sarah E Tully; Michael Niederweis; Benjamin F Cravatt; Julie A Leary; Carolyn R Bertozzi
Elucidation and chemical modulation of sulfolipid-1 biosynthesis in Mycobacterium tuberculosis.
The Journal of biological chemistry 2012;287(11):7990-8000.
2012: Seul Ki Lim; Min Jung Park; Jae Cheong Lim; Jong Choon Kim; Ho Jae Han; Gye-Yeop Kim; Benjamin F Cravatt; Chang Hoon Woo; Seung Jin Ma; Kyung Cheol Yoon; et al.
Hyperglycemia induces apoptosis via CB1 activation through the decrease of FAAH 1 in retinal pigment epithelial cells.
Journal of cellular physiology 2012;227(2):569-77.
2012: Raymond E Moellering; Benjamin F Cravatt
How chemoproteomics can enable drug discovery and development.
Chemistry & biology 2012;19(1):11-22.
2012: Jae Won Chang; Raymond E Moellering; Benjamin F Cravatt
An activity-based imaging probe for the integral membrane hydrolase KIAA1363.
Angewandte Chemie (International ed. in English) 2012;51(4):966-70.
2012: Michael Rothmann; Sherry Niessen; Robert W Haushalter; Benjamin F Cravatt; Michael D Burkart
Resin-based investigation of acyl carrier protein interaction networks in Escherichia coli.
Bioorganic & medicinal chemistry 2012;20(2):667-71.
2012: Farnusch Kaschani; Sabrina Nickel; Bikram Pandey; Benjamin F Cravatt; Markus Kaiser; Renier A L van der Hoorn
Selective inhibition of plant serine hydrolases by agrochemicals revealed by competitive ABPP.
Bioorganic & medicinal chemistry 2012;20(2):597-600.
2011: Daniel K Nomura; Bradley E Morrison; Jacqueline L Blankman; Jonathan Z Long; Steven G Kinsey; Maria Cecilia G Marcondes; Anna M Ward; Yun Kyung Hahn; Aron H Lichtman; Bruno Conti; et al.
Endocannabinoid hydrolysis generates brain prostaglandins that promote neuroinflammation.
Science (New York, N.Y.) 2011;334(6057):809-13.
2011: Jonathan Z Long; Justin S Cisar; David Milliken; Sherry Niessen; Chu Wang; Sunia A Trauger; Gary Siuzdak; Benjamin F Cravatt
Metabolomics annotates ABHD3 as a physiologic regulator of medium-chain phospholipids.
Nature chemical biology 2011;7(11):763-5.
2011: Katsunori Tsuboi; Daniel A Bachovchin; Anna E Speers; Timothy P Spicer; Virneliz Fernandez-Vega; Peter Hodder; Hugh Rosen; Benjamin F Cravatt
Potent and selective inhibitors of glutathione S-transferase omega 1 that impair cancer drug resistance.
Journal of the American Chemical Society 2011;133(41):16605-16.
2011: Peng Zhong; Bin Pan; Xiu-ping Gao; Jacqueline L Blankman; Benjamin F Cravatt; Qing-song Liu
Genetic deletion of monoacylglycerol lipase alters endocannabinoid-mediated retrograde synaptic depression in the cerebellum.
The Journal of physiology 2011;589(Pt 20):4847-55.
2011: Jonathan Z Long; Benjamin F Cravatt
The metabolic serine hydrolases and their functions in mammalian physiology and disease.
Chemical reviews 2011;111(10):6022-63.
2011: Steven G Kinsey; Pattipati S Naidu; Benjamin F Cravatt; David T Dudley; Aron H Lichtman
Fatty acid amide hydrolase blockade attenuates the development of collagen-induced arthritis and related thermal hyperalgesia in mice.
Pharmacology, biochemistry, and behavior 2011;99(4):718-25.
2011: Divya Ramesh; Gracious R Ross; Joel E Schlosburg; Robert A Owens; Rehab A Abdullah; Steven G Kinsey; Jonathan Z Long; Daniel K Nomura; Laura J Sim-Selley; Benjamin F Cravatt; et al.
Blockade of endocannabinoid hydrolytic enzymes attenuates precipitated opioid withdrawal symptoms in mice.
The Journal of pharmacology and experimental therapeutics 2011;339(1):173-85.
2011: Bin Pan; Wei Wang; Peng Zhong; Jacqueline L Blankman; Benjamin F Cravatt; Qing-song Liu
Alterations of endocannabinoid signaling, synaptic plasticity, learning, and memory in monoacylglycerol lipase knock-out mice.
The Journal of neuroscience : the official journal of the Society for Neuroscience 2011;31(38):13420-30.
2011: Steven G Kinsey; Daniel K Nomura; Scott T O'Neal; Jonathan Z Long; Anu Mahadevan; Benjamin F Cravatt; John R Grider; Aron H Lichtman
Inhibition of monoacylglycerol lipase attenuates nonsteroidal anti-inflammatory drug-induced gastric hemorrhages in mice.
The Journal of pharmacology and experimental therapeutics 2011;338(3):795-802.
2011: Anna Mari Lone; Daniel A Bachovchin; David B Westwood; Anna E Speers; Timothy P Spicer; Virneliz Fernandez-Vega; Peter Chase; Peter S Hodder; Hugh Rosen; Benjamin F Cravatt; et al.
A substrate-free activity-based protein profiling screen for the discovery of selective PREPL inhibitors.
Journal of the American Chemical Society 2011;133(30):11665-74.
2011: Silvia Rossi; Roberto Furlan; Valentina De Chiara; Luca Muzio; Alessandra Musella; Caterina Motta; Valeria Studer; Francesca Cavasinni; Giorgio Bernardi; Gianvito Martino; et al.
Cannabinoid CB1 receptors regulate neuronal TNF-α effects in experimental autoimmune encephalomyelitis.
Brain, behavior, and immunity 2011;25(6):1242-8.
2011: Daniel A Bachovchin; Andrea M Zuhl; Anna E Speers; Monique R Wolfe; Eranthie Weerapana; Steven J Brown; Hugh Rosen; Benjamin F Cravatt
Discovery and optimization of sulfonyl acrylonitriles as selective, covalent inhibitors of protein phosphatase methylesterase-1.
Journal of medicinal chemistry 2011;54(14):5229-36.
2011: Alexander Adibekian; Brent R Martin; Chu Wang; Ku-Lung Hsu; Daniel A Bachovchin; Sherry Niessen; Heather Hoover; Benjamin F Cravatt
Click-generated triazole ureas as ultrapotent in vivo-active serine hydrolase inhibitors.
Nature chemical biology 2011;7(7):469-78.
2011: Kay Ahn; Sarah E Smith; Marya B Liimatta; David Beidler; Nalini Sadagopan; David T Dudley; Tim Young; Paul Wren; Yanhua Zhang; Steven Swaney; et al.
Mechanistic and pharmacological characterization of PF-04457845: a highly potent and selective fatty acid amide hydrolase inhibitor that reduces inflammatory and noninflammatory pain.
The Journal of pharmacology and experimental therapeutics 2011;338(1):114-24.
2011: Carolyn I Hall; Michael L Reese; Eranthie Weerapana; Matthew A Child; Paul W Bowyer; Victoria E Albrow; Jeralyn D Haraldsen; MacDonald R Phillips; Edgar Deu Sandoval; Gary E Ward; et al.
Chemical genetic screen identifies Toxoplasma DJ-1 as a regulator of parasite secretion, attachment, and invasion.
Proceedings of the National Academy of Sciences of the United States of America 2011;108(26):10568-73.
2011: Paul W Bowyer; Gabriel M Simon; Benjamin F Cravatt; Matthew Bogyo
Global profiling of proteolysis during rupture of Plasmodium falciparum from the host erythrocyte.
Molecular & cellular proteomics : MCP 2011;10(5):M110.001636.
2011: Cyrine Ezzili; Mauro Mileni; Nicholas McGlinchey; Jonathan Z Long; Steven G Kinsey; Dustin G Hochstatter; Raymond C Stevens; Aron H Lichtman; Benjamin F Cravatt; Edward J Bilsky; et al.
Reversible competitive α-ketoheterocycle inhibitors of fatty acid amide hydrolase containing additional conformational constraints in the acyl side chain: orally active, long-acting analgesics.
Journal of medicinal chemistry 2011;54(8):2805-22.
2011: Daniel A Bachovchin; Justin T Mohr; Anna E Speers; Chu Wang; Jacob M Berlin; Timothy P Spicer; Virneliz Fernandez-Vega; Peter Chase; Peter S Hodder; Stephan C Schürer; et al.
Academic cross-fertilization by public screening yields a remarkable class of protein phosphatase methylesterase-1 inhibitors.
Proceedings of the National Academy of Sciences of the United States of America 2011;108(17):6811-6.
2011: K C Nicolaou; Silvano Sanchini; David Sarlah; Gang Lu; T Robert Wu; Daniel K Nomura; Benjamin F Cravatt; Beatrice Cubitt; Juan C de la Torre; Ann J Hessell; et al.
Design, synthesis, and biological evaluation of a biyouyanagin compound library.
Proceedings of the National Academy of Sciences of the United States of America 2011;108(17):6715-20.
2011: Jae Won Chang; Daniel K Nomura; Benjamin F Cravatt
A potent and selective inhibitor of KIAA1363/AADACL1 that impairs prostate cancer pathogenesis.
Chemistry & biology 2011;18(4):476-84.
2011: Bani Mukhopadhyay; Resat Cinar; Shi Yin; Jie Liu; Joseph Tam; Grzegorz Godlewski; Judith Harvey-White; Isioma Mordi; Benjamin F Cravatt; Sophie Lotersztajn; et al.
Hyperactivation of anandamide synthesis and regulation of cell-cycle progression via cannabinoid type 1 (CB1) receptors in the regenerating liver.
Proceedings of the National Academy of Sciences of the United States of America 2011;108(15):6323-8.
2011: Mauro Mileni; Joie Garfunkle; Cyrine Ezzili; Benjamin F Cravatt; Raymond C Stevens; Dale L Boger
Fluoride-mediated capture of a noncovalent bound state of a reversible covalent enzyme inhibitor: X-ray crystallographic analysis of an exceptionally potent α-ketoheterocycle inhibitor of fatty acid amide hydrolase.
Journal of the American Chemical Society 2011;133(11):4092-100.
2011: Steven G Kinsey; Scott T O'Neal; Jonathan Z Long; Benjamin F Cravatt; Aron H Lichtman
Inhibition of endocannabinoid catabolic enzymes elicits anxiolytic-like effects in the marble burying assay.
Pharmacology, biochemistry, and behavior 2011;98(1):21-7.
2011: Jonathan Z Long; Melanie LaCava; Xin Jin; Benjamin F Cravatt
An anatomical and temporal portrait of physiological substrates for fatty acid amide hydrolase.
Journal of lipid research 2011;52(2):337-44.
2011: Jordan L Meier; Anand D Patel; Sherry Niessen; Michael Meehan; Roland Kersten; Jane Y Yang; Michael Rothmann; Benjamin F Cravatt; Pieter C Dorrestein; Michael D Burkart; et al.
Practical 4'-phosphopantetheine active site discovery from proteomic samples.
Journal of proteome research 2011;10(1):320-9.
2011: Partha Mukhopadhyay; Bėla Horváth; Mohanraj Rajesh; Shingo Matsumoto; Keita Saito; Sándor Bátkai; Vivek Patel; Galin Tanchian; Rachel Y Gao; Benjamin F Cravatt; et al.
Fatty acid amide hydrolase is a key regulator of endocannabinoid-induced myocardial tissue injury.
Free radical biology & medicine 2011;50(1):179-95.
2010: Eranthie Weerapana; Chu Wang; Gabriel M Simon; Florian Richter; Sagar Khare; Myles B D Dillon; Daniel A Bachovchin; Kerri Mowen; David Baker; Benjamin F Cravatt
Quantitative reactivity profiling predicts functional cysteines in proteomes.
Nature 2010;468(7325):790-5.
2010: Daniel A Bachovchin; Tianyang Ji; Weiwei Li; Gabriel M Simon; Jacqueline L Blankman; Alexander Adibekian; Heather Hoover; Sherry Niessen; Benjamin F Cravatt
Superfamily-wide portrait of serine hydrolase inhibition achieved by library-versus-library screening.
Proceedings of the National Academy of Sciences of the United States of America 2010;107(49):20941-6.
2010: Alban Gaultier; Gabriel Simon; Sherry Niessen; Melissa Dix; Shinako Takimoto; Benjamin F Cravatt; Steven L Gonias
LDL receptor-related protein 1 regulates the abundance of diverse cell-signaling proteins in the plasma membrane proteome.
Journal of proteome research 2010;9(12):6689-95.
2010: Aron H Lichtman; Jacqueline L Blankman; Benjamin F Cravatt
Endocannabinoid overload.
Molecular pharmacology 2010;78(6):993-5.
2010: Steven G Kinsey; Jonathan Z Long; Benjamin F Cravatt; Aron H Lichtman
Fatty acid amide hydrolase and monoacylglycerol lipase inhibitors produce anti-allodynic effects in mice through distinct cannabinoid receptor mechanisms.
The journal of pain : official journal of the American Pain Society 2010;11(12):1420-8.
2010: Grzegorz Godlewski; Shakiru O Alapafuja; Sándor Bátkai; Spyros P Nikas; Resat Cinar; László Offertáler; Douglas Osei-Hyiaman; Jie Liu; Bani Mukhopadhyay; Judith Harvey-White; et al.
Inhibitor of fatty acid amide hydrolase normalizes cardiovascular function in hypertension without adverse metabolic effects.
Chemistry & biology 2010;17(11):1256-66.
2010: Bryan Knuckley; Justin E Jones; Daniel A Bachovchin; Jessica Slack; Corey P Causey; Steven J Brown; Hugh Rosen; Benjamin F Cravatt; Paul R Thompson
A fluopol-ABPP HTS assay to identify PAD inhibitors.
Chemical communications (Cambridge, England) 2010;46(38):7175-7.
2010: Anna E Speers; Benjamin F Cravatt
Ligands in crystal structures that aid in functional characterization.
Acta crystallographica. Section F, Structural biology and crystallization communications 2010;66(Pt 10):1306-8.
2010: Heiko Wurdak; Shoutian Zhu; Kyung Hoon Min; Lindsey Aimone; Luke L Lairson; James Watson; Gregory Chopiuk; James Demas; Bradley Charette; Rajkumar Halder; et al.
A small molecule accelerates neuronal differentiation in the adult rat.
Proceedings of the National Academy of Sciences of the United States of America 2010;107(38):16542-7.
2010: Sherry Shu-Jung Hu; Andy Arnold; Jacqueline M Hutchens; Josh Radicke; Benjamin F Cravatt; Jim Wager-Miller; Ken Mackie; Alex Straiker
Architecture of cannabinoid signaling in mouse retina.
The Journal of comparative neurology 2010;518(18):3848-66.
2010: Joel E Schlosburg; Jacqueline L Blankman; Jonathan Z Long; Daniel K Nomura; Bin Pan; Steven G Kinsey; Peter T Nguyen; Divya Ramesh; Lamont Booker; James J Burston; et al.
Chronic monoacylglycerol lipase blockade causes functional antagonism of the endocannabinoid system.
Nature neuroscience 2010;13(9):1113-9.
2010: Daniel K Nomura; Melissa M Dix; Benjamin F Cravatt
Activity-based protein profiling for biochemical pathway discovery in cancer.
Nature reviews. Cancer 2010;10(9):630-8.
2010: Florian Kopp; Toru Komatsu; Daniel K Nomura; Sunia A Trauger; Jason R Thomas; Gary Siuzdak; Gabriel M Simon; Benjamin F Cravatt
The glycerophospho metabolome and its influence on amino acid homeostasis revealed by brain metabolomics of GDE1(-/-) mice.
Chemistry & biology 2010;17(8):831-40.
2010: Pamela W Steen; Sufang Tian; Sarah E Tully; Benjamin F Cravatt; Ellen K LeMosy
Activation of Snake in a serine protease cascade that defines the dorsoventral axis is atypical and pipe-independent in Drosophila embryos.
FEBS letters 2010;584(16):3557-60.
2010: William R Marrs; Jacqueline L Blankman; Eric A Horne; Aurore Thomazeau; Yi Hsing Lin; Jonathan Coy; Agnes L Bodor; Giulio G Muccioli; Sherry Shu-Jung Hu; Grace Woodruff; et al.
The serine hydrolase ABHD6 controls the accumulation and efficacy of 2-AG at cannabinoid receptors.
Nature neuroscience 2010;13(8):951-7.
2010: Benjamin F Cravatt; Thomas Kodadek
The interface of chemical biology and the nervous system (related to the NIDA Chemical Genomics Symposium).
Molecular bioSystems 2010;6(8):1337.
2010: Silvia Rossi; Valentina De Chiara; Alessandra Musella; Lucia Sacchetti; Cristina Cantarella; Maura Castelli; Francesca Cavasinni; Caterina Motta; Valeria Studer; Giorgio Bernardi; et al.
Preservation of striatal cannabinoid CB1 receptor function correlates with the antianxiety effects of fatty acid amide hydrolase inhibition.
Molecular pharmacology 2010;78(2):260-8.
2010: Gabriel M Simon; Benjamin F Cravatt
Characterization of mice lacking candidate N-acyl ethanolamine biosynthetic enzymes provides evidence for multiple pathways that contribute to endocannabinoid production in vivo.
Molecular bioSystems 2010;6(8):1411-8.
2010: Mauro Mileni; Satwik Kamtekar; David C Wood; Timothy E Benson; Benjamin F Cravatt; Raymond C Stevens
Crystal structure of fatty acid amide hydrolase bound to the carbamate inhibitor URB597: discovery of a deacylating water molecule and insight into enzyme inactivation.
Journal of molecular biology 2010;400(4):743-54.
2010: Pattipati S Naidu; Steven G Kinsey; Tai L Guo; Benjamin F Cravatt; Aron H Lichtman
Regulation of inflammatory pain by inhibition of fatty acid amide hydrolase.
The Journal of pharmacology and experimental therapeutics 2010;334(1):182-90.
2010: Katherine W Falenski; Andrew J Thorpe; Joel E Schlosburg; Benjamin F Cravatt; Rehab A Abdullah; Tricia H Smith; Dana E Selley; Aron H Lichtman; Laura J Sim-Selley
FAAH-/- mice display differential tolerance, dependence, and cannabinoid receptor adaptation after delta 9-tetrahydrocannabinol and anandamide administration.
Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology 2010;35(8):1775-87.
2010: Douglas S Johnson; Eranthie Weerapana; Benjamin F Cravatt
Strategies for discovering and derisking covalent, irreversible enzyme inhibitors.
Future medicinal chemistry 2010;2(6):949-64.
2010: Stefan Freigang; Victoria Zadorozhny; Michele K McKinney; Philippe Krebs; Rana Herro; Joanna Pawlak; Lisa Kain; Nicolas Schrantz; Kim Masuda; Yang Liu; et al.
Fatty acid amide hydrolase shapes NKT cell responses by influencing the serum transport of lipid antigen in mice.
The Journal of clinical investigation 2010;120(6):1873-84.
2010: T N C Ramya; Eranthie Weerapana; Lujian Liao; Ying Zeng; Hiroaki Tateno; Liang Liao; John R Yates; Benjamin F Cravatt; James C Paulson
In situ trans ligands of CD22 identified by glycan-protein photocross-linking-enabled proteomics.
Molecular & cellular proteomics : MCP 2010;9(6):1339-51.
2010: Gabriel M Simon; Benjamin F Cravatt
Activity-based proteomics of enzyme superfamilies: serine hydrolases as a case study.
The Journal of biological chemistry 2010;285(15):11051-5.
2010: Benjamin F Cravatt; Joel M Gottesfeld
Chemical biology meets biological chemistry minireview series.
The Journal of biological chemistry 2010;285(15):11031-2.
2010: Daniel A Bachovchin; Monique R Wolfe; Kim Masuda; Steven J Brown; Timothy P Spicer; Virneliz Fernandez-Vega; Peter Chase; Peter S Hodder; Hugh Rosen; Benjamin F Cravatt
Oxime esters as selective, covalent inhibitors of the serine hydrolase retinoblastoma-binding protein 9 (RBBP9).
Bioorganic & medicinal chemistry letters 2010;20(7):2254-8.
2010: Sarah E Tully; Benjamin F Cravatt
Activity-based probes that target functional subclasses of phospholipases in proteomes.
Journal of the American Chemical Society 2010;132(10):3264-5.
2010: Jonathan Z Long; Xin Jin; Alexander Adibekian; Weiwei Li; Benjamin F Cravatt
Characterization of tunable piperidine and piperazine carbamates as inhibitors of endocannabinoid hydrolases.
Journal of medicinal chemistry 2010;53(4):1830-42.
2010: David J Shields; Sherry Niessen; Eric A Murphy; Ainhoa Mielgo; Jay S Desgrosellier; Steven K M Lau; Leo A Barnes; Jacqueline Lesperance; Michael Bouvet; David Tarin; et al.
RBBP9: a tumor-associated serine hydrolase activity required for pancreatic neoplasia.
Proceedings of the National Academy of Sciences of the United States of America 2010;107(5):2189-94.
2010: Mauro Mileni; Joie Garfunkle; Cyrine Ezzili; F Scott Kimball; Benjamin F Cravatt; Raymond C Stevens; Dale L Boger
X-ray crystallographic analysis of alpha-ketoheterocycle inhibitors bound to a humanized variant of fatty acid amide hydrolase.
Journal of medicinal chemistry 2010;53(1):230-40.
2010: Daniel K Nomura; Jonathan Z Long; Sherry Niessen; Heather S Hoover; Shu-Wing Ng; Benjamin F Cravatt
Monoacylglycerol lipase regulates a fatty acid network that promotes cancer pathogenesis.
Cell 2010;140(1):49-61.
2010: Jack C Sipe; T Michael Scott; Sarah Murray; Olivier Harismendy; Gabriel M Simon; Benjamin F Cravatt; Jill Waalen
Biomarkers of endocannabinoid system activation in severe obesity.
PloS one 2010;5(1):e8792.
2009: Jonathan Z Long; Daniel K Nomura; Robert E Vann; D Matthew Walentiny; Lamont Booker; Xin Jin; James J Burston; Laura J Sim-Selley; Aron H Lichtman; Jenny L Wiley; et al.
Dual blockade of FAAH and MAGL identifies behavioral processes regulated by endocannabinoid crosstalk in vivo.
Proceedings of the National Academy of Sciences of the United States of America 2009;106(48):20270-5.
2009: Alex Straiker; Sherry Shu-Jung Hu; Jonathan Z Long; Andy Arnold; Jim Wager-Miller; Benjamin F Cravatt; Ken Mackie
Monoacylglycerol lipase limits the duration of endocannabinoid-mediated depolarization-induced suppression of excitation in autaptic hippocampal neurons.
Molecular pharmacology 2009;76(6):1220-7.
2009: Jordan L Meier; Sherry Niessen; Heather S Hoover; Timothy L Foley; Benjamin F Cravatt; Michael D Burkart
An orthogonal active site identification system (OASIS) for proteomic profiling of natural product biosynthesis.
ACS chemical biology 2009;4(11):948-57.
2009: Bin Pan; Wei Wang; Jonathan Z Long; Dalong Sun; Cecilia J Hillard; Benjamin F Cravatt; Qing-song Liu
Blockade of 2-arachidonoylglycerol hydrolysis by selective monoacylglycerol lipase inhibitor 4-nitrophenyl 4-(dibenzo[d][1,3]dioxol-5-yl(hydroxy)methyl)piperidine-1-carboxylate (JZL184) Enhances retrograde endocannabinoid signaling.
The Journal of pharmacology and experimental therapeutics 2009;331(2):591-7.
2009: Sherry Shu-Jung Hu; Heather B Bradshaw; Valery M Benton; Jay Shih-Chieh Chen; Susan M Huang; Alberto Minassi; Tiziana Bisogno; Kim Masuda; Bo Tan; Robert Roskoski; et al.
The biosynthesis of N-arachidonoyl dopamine (NADA), a putative endocannabinoid and endovanilloid, via conjugation of arachidonic acid with dopamine.
Prostaglandins, leukotrienes, and essential fatty acids 2009;81(4):291-301.
2009: Eduard Sabidó; Teresa Tarragó; Sherry Niessen; Benjamin F Cravatt; Ernest Giralt
Activity-based probes for monitoring postproline protease activity.
Chembiochem : a European journal of chemical biology 2009;10(14):2361-6.
2009: S G Kinsey; J Z Long; S T O'Neal; R A Abdullah; J L Poklis; D L Boger; B F Cravatt; A H Lichtman
Blockade of endocannabinoid-degrading enzymes attenuates neuropathic pain.
The Journal of pharmacology and experimental therapeutics 2009;330(3):902-10.
2009: Mauro Mileni; Joie Garfunkle; Jessica K DeMartino; Benjamin F Cravatt; Dale L Boger; Raymond C Stevens
Binding and inactivation mechanism of a humanized fatty acid amide hydrolase by alpha-ketoheterocycle inhibitors revealed from cocrystal structures.
Journal of the American Chemical Society 2009;131(30):10497-506.
2009: Aaron T Wright; Joongyu D Song; Benjamin F Cravatt
A suite of activity-based probes for human cytochrome P450 enzymes.
Journal of the American Chemical Society 2009;131(30):10692-700.
2009: Jonathan Z Long; Daniel K Nomura; Benjamin F Cravatt
Characterization of monoacylglycerol lipase inhibition reveals differences in central and peripheral endocannabinoid metabolism.
Chemistry & biology 2009;16(7):744-53.
2009: Gabriel M Simon; Melissa M Dix; Benjamin F Cravatt
Comparative assessment of large-scale proteomic studies of apoptotic proteolysis.
ACS chemical biology 2009;4(6):401-8.
2009: Joel E Schlosburg; Brittany L A Carlson; Divya Ramesh; Rehab A Abdullah; Jonathan Z Long; Benjamin F Cravatt; Aron H Lichtman
Inhibitors of endocannabinoid-metabolizing enzymes reduce precipitated withdrawal responses in THC-dependent mice.
The AAPS journal 2009;11(2):342-52.
2009: Douglas S Johnson; Kay Ahn; Suzanne Kesten; Scott E Lazerwith; Yuntao Song; Mark Morris; Lorraine Fay; Tracy Gregory; Cory Stiff; James B Dunbar; et al.
Benzothiophene piperazine and piperidine urea inhibitors of fatty acid amide hydrolase (FAAH).
Bioorganic & medicinal chemistry letters 2009;19(10):2865-9.
2009: Farnusch Kaschani; Christian Gu; Sherry Niessen; Heather Hoover; Benjamin F Cravatt; Renier A L van der Hoorn
Diversity of serine hydrolase activities of unchallenged and botrytis-infected Arabidopsis thaliana.
Molecular & cellular proteomics : MCP 2009;8(5):1082-93.
2009: Kay Ahn; Douglas S Johnson; Mauro Mileni; David Beidler; Jonathan Z Long; Michele K McKinney; Eranthie Weerapana; Nalini Sadagopan; Marya Liimatta; Sarah E Smith; et al.
Discovery and characterization of a highly selective FAAH inhibitor that reduces inflammatory pain.
Chemistry & biology 2009;16(4):411-20.
2009: Daniel A Bachovchin; Steven J Brown; Hugh Rosen; Benjamin F Cravatt
Identification of selective inhibitors of uncharacterized enzymes by high-throughput screening with fluorescent activity-based probes.
Nature biotechnology 2009;27(4):387-94.
2009: Joel E Schlosburg; Dale L Boger; Benjamin F Cravatt; Aron H Lichtman
Endocannabinoid modulation of scratching response in an acute allergenic model: a new prospective neural therapeutic target for pruritus.
The Journal of pharmacology and experimental therapeutics 2009;329(1):314-23.
2009: Pattipati S Naidu; Lamont Booker; Benjamin F Cravatt; Aron H Lichtman
Synergy between enzyme inhibitors of fatty acid amide hydrolase and cyclooxygenase in visceral nociception.
The Journal of pharmacology and experimental therapeutics 2009;329(1):48-56.
2009: Isobel J Lever; Michelle Robinson; Mario Cibelli; Cleoper Paule; Peter Santha; Louis Yee; Stephen P Hunt; Benjamin F Cravatt; Maurice R Elphick; Istvan Nagy; et al.
Localization of the endocannabinoid-degrading enzyme fatty acid amide hydrolase in rat dorsal root ganglion cells and its regulation after peripheral nerve injury.
The Journal of neuroscience : the official journal of the Society for Neuroscience 2009;29(12):3766-80.
2009: Brent R Martin; Benjamin F Cravatt
Large-scale profiling of protein palmitoylation in mammalian cells.
Nature methods 2009;6(2):135-8.
2009: Xiaofei Sun; Haibin Wang; Masaru Okabe; Kenneth Mackie; Philip J Kingsley; Lawrence J Marnett; Benjamin F Cravatt; Sudhansu K Dey
Genetic loss of Faah compromises male fertility in mice.
Biology of reproduction 2009;80(2):235-42.
2009: Ryuichiro Nakai; Cleo M Salisbury; Hugh Rosen; Benjamin F Cravatt
Ranking the selectivity of PubChem screening hits by activity-based protein profiling: MMP13 as a case study.
Bioorganic & medicinal chemistry 2009;17(3):1101-8.
2009: Heather B Bradshaw; Neta Rimmerman; Sherry Shu-Jung Hu; Valery M Benton; Jordyn M Stuart; Kim Masuda; Benjamin F Cravatt; David K O'Dell; J Michael Walker
The endocannabinoid anandamide is a precursor for the signaling lipid N-arachidonoyl glycine by two distinct pathways.
BMC biochemistry 2009;10():14.
2008: Benjamin F Cravatt
Tetrahedron young investigator award 2008.
Bioorganic & medicinal chemistry letters 2008;18(22):5837.
2008: Heather S Hoover; Jacqueline L Blankman; Sherry Niessen; Benjamin F Cravatt
Selectivity of inhibitors of endocannabinoid biosynthesis evaluated by activity-based protein profiling.
Bioorganic & medicinal chemistry letters 2008;18(22):5838-41.
2008: Ian M Slaymaker; Michael Bracey; Mauro Mileni; Joie Garfunkle; Benjamin F Cravatt; Dale L Boger; Raymond C Stevens
Correlation of inhibitor effects on enzyme activity and thermal stability for the integral membrane protein fatty acid amide hydrolase.
Bioorganic & medicinal chemistry letters 2008;18(22):5847-50.
2008: Jessica K DeMartino; Joie Garfunkle; Dustin G Hochstatter; Benjamin F Cravatt; Dale L Boger
Exploration of a fundamental substituent effect of alpha-ketoheterocycle enzyme inhibitors: Potent and selective inhibitors of fatty acid amide hydrolase.
Bioorganic & medicinal chemistry letters 2008;18(22):5842-6.
2008: Gabriel M Simon; Benjamin F Cravatt
Challenges for the 'chemical-systems' biologist.
Nature chemical biology 2008;4(11):639-42.
2008: Erin M Conn; Mark A Madsen; Benjamin F Cravatt; Wolfram Ruf; Elena I Deryugina; James P Quigley
Cell surface proteomics identifies molecules functionally linked to tumor cell intravasation.
The Journal of biological chemistry 2008;283(39):26518-27.
2008: Mauro Mileni; Douglas S Johnson; Zhigang Wang; Daniel S Everdeen; Marya Liimatta; Brandon Pabst; Keshab Bhattacharya; Richard A Nugent; Satwik Kamtekar; Benjamin F Cravatt; et al.
Structure-guided inhibitor design for human FAAH by interspecies active site conversion.
Proceedings of the National Academy of Sciences of the United States of America 2008;105(35):12820-4.
2008: Melissa M Dix; Gabriel M Simon; Benjamin F Cravatt
Global mapping of the topography and magnitude of proteolytic events in apoptosis.
Cell 2008;134(4):679-91.
2008: Juan Suárez; Francisco Javier Bermúdez-Silva; Ken Mackie; Catherine Ledent; Andreas Zimmer; Benjamin F Cravatt; Fernando Rodríguez de Fonseca
Immunohistochemical description of the endogenous cannabinoid system in the rat cerebellum and functionally related nuclei.
The Journal of comparative neurology 2008;509(4):400-21.
2008: Eranthie Weerapana; Gabriel M Simon; Benjamin F Cravatt
Disparate proteome reactivity profiles of carbon electrophiles.
Nature chemical biology 2008;4(7):405-7.
2008: Neta Rimmerman; Heather B Bradshaw; H Velocity Hughes; Jay Shih-Chieh Chen; Sherry Shu-Jung Hu; Douglas McHugh; Eivind Vefring; Jan A Jahnsen; Eric L Thompson; Kim Masuda; et al.
N-palmitoyl glycine, a novel endogenous lipid that acts as a modulator of calcium influx and nitric oxide production in sensory neurons.
Molecular pharmacology 2008;74(1):213-24.
2008: Venkatesh L Hegde; Shweta Hegde; Benjamin F Cravatt; Lorne J Hofseth; Mitzi Nagarkatti; Prakash S Nagarkatti
Attenuation of experimental autoimmune hepatitis by exogenous and endogenous cannabinoids: involvement of regulatory T cells.
Molecular pharmacology 2008;74(1):20-33.
2008: Daniel K Nomura; Jacqueline L Blankman; Gabriel M Simon; Kazutoshi Fujioka; Roger S Issa; Anna M Ward; Benjamin F Cravatt; John E Casida
Activation of the endocannabinoid system by organophosphorus nerve agents.
Nature chemical biology 2008;4(6):373-8.
2008: Alban Gaultier; Sanja Arandjelovic; Sherry Niessen; Cheryl D Overton; MacRae F Linton; Sergio Fazio; W Marie Campana; Benjamin F Cravatt; Steven L Gonias
Regulation of tumor necrosis factor receptor-1 and the IKK-NF-kappaB pathway by LDL receptor-related protein explains the antiinflammatory activity of this receptor.
Blood 2008;111(11):5316-25.
2008: Kay Ahn; Michele K McKinney; Benjamin F Cravatt
Enzymatic pathways that regulate endocannabinoid signaling in the nervous system.
Chemical reviews 2008;108(5):1687-707.
2008: Gabriel M Simon; Benjamin F Cravatt
Anandamide biosynthesis catalyzed by the phosphodiesterase GDE1 and detection of glycerophospho-N-acyl ethanolamine precursors in mouse brain.
The Journal of biological chemistry 2008;283(14):9341-9.
2008: Daniel K Nomura; Kazutoshi Fujioka; Roger S Issa; Anna M Ward; Benjamin F Cravatt; John E Casida
Dual roles of brain serine hydrolase KIAA1363 in ether lipid metabolism and organophosphate detoxification.
Toxicology and applied pharmacology 2008;228(1):42-8.
2008: Melissa V Turman; Philip J Kingsley; Carol A Rouzer; Benjamin F Cravatt; Lawrence J Marnett
Oxidative metabolism of a fatty acid amide hydrolase-regulated lipid, arachidonoyltaurine.
Biochemistry 2008;47(12):3917-25.
2008: Cleo M Salisbury; Benjamin F Cravatt
Optimization of activity-based probes for proteomic profiling of histone deacetylase complexes.
Journal of the American Chemical Society 2008;130(7):2184-94.
2008: Mauro Maccarrone; Silvia Rossi; Monica Bari; Valentina De Chiara; Filomena Fezza; Alessandra Musella; Valeria Gasperi; Chiara Prosperetti; Giorgio Bernardi; Alessandro Finazzi-Agrò; et al.
Anandamide inhibits metabolism and physiological actions of 2-arachidonoylglycerol in the striatum.
Nature neuroscience 2008;11(2):152-9.
2008: Michaela Egertová; Gabriel M Simon; Benjamin F Cravatt; Maurice R Elphick
Localization of N-acyl phosphatidylethanolamine phospholipase D (NAPE-PLD) expression in mouse brain: A new perspective on N-acylethanolamines as neural signaling molecules.
The Journal of comparative neurology 2008;506(4):604-15.
2008: Rita Nyilas; Barna Dudok; Gabriella M Urbán; Ken Mackie; Masahiko Watanabe; Benjamin F Cravatt; Tamás F Freund; István Katona
Enzymatic machinery for endocannabinoid biosynthesis associated with calcium stores in glutamatergic axon terminals.
The Journal of neuroscience : the official journal of the Society for Neuroscience 2008;28(5):1058-63.
2008: Silvia Ortega-Gutiérrez; Donmienne Leung; Scott Ficarro; Eric C Peters; Benjamin F Cravatt
Targeted disruption of the PME-1 gene causes loss of demethylated PP2A and perinatal lethality in mice.
PloS one 2008;3(7):e2486.
2008: Benjamin F Cravatt; Aaron T Wright; John W Kozarich
Activity-based protein profiling: from enzyme chemistry to proteomic chemistry.
Annual review of biochemistry 2008;77():383-414.
2008: Laura E Wise; Roberta Cannavacciulo; Benjamin F Cravatt; Billy F Martin; Aron H Lichtman
Evaluation of fatty acid amides in the carrageenan-induced paw edema model.
Neuropharmacology 2008;54(1):181-8.
2007: Erin E Carlson; Benjamin F Cravatt
Enrichment tags for enhanced-resolution profiling of the polar metabolome.
Journal of the American Chemical Society 2007;129(51):15780-2.
2007: Karin List; Brooke Currie; Tiffany C Scharschmidt; Roman Szabo; Jessica Shireman; Alfredo Molinolo; Benjamin F Cravatt; Julia Segre; Thomas H Bugge
Autosomal ichthyosis with hypotrichosis syndrome displays low matriptase proteolytic activity and is phenocopied in ST14 hypomorphic mice.
The Journal of biological chemistry 2007;282(50):36714-23.
2007: Benjamin F Cravatt; Gabriel M Simon; John R Yates
The biological impact of mass-spectrometry-based proteomics.
Nature 2007;450(7172):991-1000.
2007: Pablo Chamero; Tobias F Marton; Darren W Logan; Kelly Flanagan; Jason R Cruz; Alan Saghatelian; Benjamin F Cravatt; Lisa Stowers
Identification of protein pheromones that promote aggressive behaviour.
Nature 2007;450(7171):899-902.
2007: Jacqueline L Blankman; Gabriel M Simon; Benjamin F Cravatt
A comprehensive profile of brain enzymes that hydrolyze the endocannabinoid 2-arachidonoylglycerol.
Chemistry & biology 2007;14(12):1347-56.
2007: Kyunghye Ahn; Douglas S Johnson; Laura R Fitzgerald; Marya Liimatta; Andrea Arendse; Tracy Stevenson; Eric T Lund; Richard A Nugent; Tyzoon K Nomanbhoy; Jessica P Alexander; et al.
Novel mechanistic class of fatty acid amide hydrolase inhibitors with remarkable selectivity.
Biochemistry 2007;46(45):13019-30.
2007: Lindsey J Macpherson; Bailong Xiao; Kelvin Y Kwan; Matt J Petrus; Adrienne E Dubin; SunWook Hwang; Benjamin Cravatt; David P Corey; Ardem Patapoutian
An ion channel essential for sensing chemical damage.
The Journal of neuroscience : the official journal of the Society for Neuroscience 2007;27(42):11412-5.
2007: Katherine T Barglow; Benjamin F Cravatt
Activity-based protein profiling for the functional annotation of enzymes.
Nature methods 2007;4(10):822-7.
2007: Patrick A Everley; Carlos A Gartner; Wilhelm Haas; Alan Saghatelian; Joshua E Elias; Benjamin F Cravatt; Bruce R Zetter; Steven P Gygi
Assessing enzyme activities using stable isotope labeling and mass spectrometry.
Molecular & cellular proteomics : MCP 2007;6(10):1771-7.
2007: Aaron T Wright; Benjamin F Cravatt
Chemical proteomic probes for profiling cytochrome p450 activities and drug interactions in vivo.
Chemistry & biology 2007;14(9):1043-51.
2007: Andrew Vila; Anja Rosengarth; Daniele Piomelli; Benjamin Cravatt; Lawrence J Marnett
Hydrolysis of prostaglandin glycerol esters by the endocannabinoid-hydrolyzing enzymes, monoacylglycerol lipase and fatty acid amide hydrolase.
Biochemistry 2007;46(33):9578-85.
2007: Weiwei Li; Jacqueline L Blankman; Benjamin F Cravatt
A functional proteomic strategy to discover inhibitors for uncharacterized hydrolases.
Journal of the American Chemical Society 2007;129(31):9594-5.
2007: Yihong Wan; Alan Saghatelian; Ling-Wa Chong; Chun-Li Zhang; Benjamin F Cravatt; Ronald M Evans
Maternal PPAR gamma protects nursing neonates by suppressing the production of inflammatory milk.
Genes & development 2007;21(15):1895-908.
2007: Sándor Bátkai; Mohanraj Rajesh; Partha Mukhopadhyay; György Haskó; Lucas Liaudet; Benjamin F Cravatt; Anna Csiszár; Zoltan Ungvári; Pál Pacher
Decreased age-related cardiac dysfunction, myocardial nitrative stress, inflammatory gene expression, and apoptosis in mice lacking fatty acid amide hydrolase.
American journal of physiology. Heart and circulatory physiology 2007;293(2):H909-18.
2007: Christophe Hardouin; Michael J Kelso; F Anthony Romero; Thomas J Rayl; Donmienne Leung; Inkyu Hwang; Benjamin F Cravatt; Dale L Boger
Structure-activity relationships of alpha-ketooxazole inhibitors of fatty acid amide hydrolase.
Journal of medicinal chemistry 2007;50(14):3359-68.
2007: Michael J Evans; Garrett M Morris; Jane Wu; Arthur J Olson; Erik J Sorensen; Benjamin F Cravatt
Mechanistic and structural requirements for active site labeling of phosphoglycerate mutase by spiroepoxides.
Molecular bioSystems 2007;3(7):495-506.
2007: Yuri A Blednov; Benjamin F Cravatt; Stephen L Boehm; Danielle Walker; R Adron Harris
Role of endocannabinoids in alcohol consumption and intoxication: studies of mice lacking fatty acid amide hydrolase.
Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology 2007;32(7):1570-82.
2007: Sarah R Hanson; Tsui-Ling Hsu; Eranthie Weerapana; Kuniyuki Kishikawa; Gabriel M Simon; Benjamin F Cravatt; Chi-Huey Wong
Tailored glycoproteomics and glycan site mapping using saccharide-selective bioorthogonal probes.
Journal of the American Chemical Society 2007;129(23):7266-7.
2007: Meliha Karsak; Evelyn Gaffal; Rahul Date; Lihua Wang-Eckhardt; Jennifer Rehnelt; Stefania Petrosino; Katarzyna Starowicz; Regina Steuder; Eberhard Schlicker; Benjamin Cravatt; et al.
Attenuation of allergic contact dermatitis through the endocannabinoid system.
Science (New York, N.Y.) 2007;316(5830):1494-7.
2007: Erin E Carlson; Benjamin F Cravatt
Chemoselective probes for metabolite enrichment and profiling.
Nature methods 2007;4(5):429-35.
2007: Pattipati S Naidu; Stephen A Varvel; Kyunghye Ahn; Benjamin F Cravatt; Billy R Martin; Aron H Lichtman
Evaluation of fatty acid amide hydrolase inhibition in murine models of emotionality.
Psychopharmacology 2007;192(1):61-70.
2007: Stephen A Varvel; Laura E Wise; Floride Niyuhire; Benjamin F Cravatt; Aron H Lichtman
Inhibition of fatty-acid amide hydrolase accelerates acquisition and extinction rates in a spatial memory task.
Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology 2007;32(5):1032-41.
2007: F Anthony Romero; Wu Du; Inkyu Hwang; Thomas J Rayl; F Scott Kimball; Donmienne Leung; Heather S Hoover; Richard L Apodaca; J Guy Breitenbucher; Benjamin F Cravatt; et al.
Potent and selective alpha-ketoheterocycle-based inhibitors of the anandamide and oleamide catabolizing enzyme, fatty acid amide hydrolase.
Journal of medicinal chemistry 2007;50(5):1058-68.
2007: Laura E Wise; Christopher C Shelton; Benjamin F Cravatt; Billy R Martin; Aron H Lichtman
Assessment of anandamide's pharmacological effects in mice deficient of both fatty acid amide hydrolase and cannabinoid CB1 receptors.
European journal of pharmacology 2007;557(1):44-8.
2007: Giampiero Mei; Almerinda Di Venere; Valeria Gasperi; Eleonora Nicolai; Kim R Masuda; Alessandro Finazzi-Agrò; Benjamin F Cravatt; Mauro Maccarrone
Closing the gate to the active site: effect of the inhibitor methoxyarachidonyl fluorophosphonate on the conformation and membrane binding of fatty acid amide hydrolase.
The Journal of biological chemistry 2007;282(6):3829-36.
2007: Haibin Wang; Huirong Xie; Xiaofei Sun; Philip J Kingsley; Lawrence J Marnett; Benjamin F Cravatt; Sudhansu K Dey
Differential regulation of endocannabinoid synthesis and degradation in the uterus during embryo implantation.
Prostaglandins & other lipid mediators 2007;83(1-2):62-74.
2007: Lindsey J Macpherson; Adrienne E Dubin; Michael J Evans; Felix Marr; Peter G Schultz; Benjamin F Cravatt; Ardem Patapoutian
Noxious compounds activate TRPA1 ion channels through covalent modification of cysteines.
Nature 2007;445(7127):541-5.
2007: Cleo M Salisbury; Benjamin F Cravatt
Activity-based probes for proteomic profiling of histone deacetylase complexes.
Proceedings of the National Academy of Sciences of the United States of America 2007;104(4):1171-6.
2007: Jin Fu; Giuseppe Astarita; Silvana Gaetani; Janet Kim; Benjamin F Cravatt; Ken Mackie; Daniele Piomelli
Food intake regulates oleoylethanolamide formation and degradation in the proximal small intestine.
The Journal of biological chemistry 2007;282(2):1518-28.
2007: Eranthie Weerapana; Anna E Speers; Benjamin F Cravatt
Tandem orthogonal proteolysis-activity-based protein profiling (TOP-ABPP)--a general method for mapping sites of probe modification in proteomes.
Nature protocols 2007;2(6):1414-25.
2006: Binqing Q Wei; Tarjei S Mikkelsen; Michele K McKinney; Eric S Lander; Benjamin F Cravatt
A second fatty acid amide hydrolase with variable distribution among placental mammals.
The Journal of biological chemistry 2006;281(48):36569-78.
2006: Katherine T Barglow; Benjamin F Cravatt
Substrate mimicry in an activity-based probe that targets the nitrilase family of enzymes.
Angewandte Chemie (International ed. in English) 2006;45(44):7408-11.
2006: Kyle P Chiang; Sherry Niessen; Alan Saghatelian; Benjamin F Cravatt
An enzyme that regulates ether lipid signaling pathways in cancer annotated by multidimensional profiling.
Chemistry & biology 2006;13(10):1041-50.
2006: Anke M Mulder; Benjamin F Cravatt
Endocannabinoid metabolism in the absence of fatty acid amide hydrolase (FAAH): discovery of phosphorylcholine derivatives of N-acyl ethanolamines.
Biochemistry 2006;45(38):11267-77.
2006: Gabriel M Simon; Benjamin F Cravatt
Endocannabinoid biosynthesis proceeding through glycerophospho-N-acyl ethanolamine and a role for alpha/beta-hydrolase 4 in this pathway.
The Journal of biological chemistry 2006;281(36):26465-72.
2006: Daniel K Nomura; Kathleen A Durkin; Kyle P Chiang; Gary B Quistad; Benjamin F Cravatt; John E Casida
Serine hydrolase KIAA1363: toxicological and structural features with emphasis on organophosphate interactions.
Chemical research in toxicology 2006;19(9):1142-50.
2006: Jessica P Alexander; Benjamin F Cravatt
The putative endocannabinoid transport blocker LY2183240 is a potent inhibitor of FAAH and several other brain serine hydrolases.
Journal of the American Chemical Society 2006;128(30):9699-704.
2006: Michael J Evans; Benjamin F Cravatt
Mechanism-based profiling of enzyme families.
Chemical reviews 2006;106(8):3279-301.
2006: Haibin Wang; Huirong Xie; Yong Guo; Hao Zhang; Toshifumi Takahashi; Philip J Kingsley; Lawrence J Marnett; Sanjoy K Das; Benjamin F Cravatt; Sudhansu K Dey
Fatty acid amide hydrolase deficiency limits early pregnancy events.
The Journal of clinical investigation 2006;116(8):2122-31.
2006: Michele K McKinney; Benjamin F Cravatt
Structure-based design of a FAAH variant that discriminates between the N-acyl ethanolamine and taurine families of signaling lipids.
Biochemistry 2006;45(30):9016-22.
2006: Alan Saghatelian; Michele K McKinney; Michael Bandell; Ardem Patapoutian; Benjamin F Cravatt
A FAAH-regulated class of N-acyl taurines that activates TRP ion channels.
Biochemistry 2006;45(30):9007-15.
2006: Amit Balakrishnan; Bhairavi Patel; Stephan A Sieber; Ding Chen; Niseema Pachikara; Guangming Zhong; Benjamin F Cravatt; Huizhou Fan
Metalloprotease inhibitors GM6001 and TAPI-0 inhibit the obligate intracellular human pathogen Chlamydia trachomatis by targeting peptide deformylase of the bacterium.
The Journal of biological chemistry 2006;281(24):16691-9.
2006: Stephan A Sieber; Benjamin F Cravatt
Analytical platforms for activity-based protein profiling--exploiting the versatility of chemistry for functional proteomics.
Chemical communications (Cambridge, England) 2006;(22):2311-9.
2006: Mark A Madsen; Elena I Deryugina; Sherry Niessen; Benjamin F Cravatt; James P Quigley
Activity-based protein profiling implicates urokinase activation as a key step in human fibrosarcoma intravasation.
The Journal of biological chemistry 2006;281(23):15997-6005.
2006: Balapal S Basavarajappa; Ratnakumar Yalamanchili; Benjamin F Cravatt; Thomas B Cooper; Basalingappa L Hungund
Increased ethanol consumption and preference and decreased ethanol sensitivity in female FAAH knockout mice.
Neuropharmacology 2006;50(7):834-44.
2006: Stephan A Sieber; Sherry Niessen; Heather S Hoover; Benjamin F Cravatt
Proteomic profiling of metalloprotease activities with cocktails of active-site probes.
Nature chemical biology 2006;2(5):274-81.
2006: Donmienne Leung; Alan Saghatelian; Gabriel M Simon; Benjamin F Cravatt
Inactivation of N-acyl phosphatidylethanolamine phospholipase D reveals multiple mechanisms for the biosynthesis of endocannabinoids.
Biochemistry 2006;45(15):4720-6.
2006: Sören V Siegmund; Ekihiro Seki; Yosuke Osawa; Hiroshi Uchinami; Benjamin F Cravatt; Robert F Schwabe
Fatty acid amide hydrolase determines anandamide-induced cell death in the liver.
The Journal of biological chemistry 2006;281(15):10431-8.
2006: Stephen A Varvel; Benjamin F Cravatt; April E Engram; Aron H Lichtman
Fatty acid amide hydrolase (-/-) mice exhibit an increased sensitivity to the disruptive effects of anandamide or oleamide in a working memory water maze task.
The Journal of pharmacology and experimental therapeutics 2006;317(1):251-7.
2006: Tania Aguado; Javier Palazuelos; Krisztina Monory; Nephi Stella; Benjamin Cravatt; Beat Lutz; Giovanni Marsicano; Zaal Kokaia; Manuel Guzmán; Ismael Galve-Roperh
The endocannabinoid system promotes astroglial differentiation by acting on neural progenitor cells.
The Journal of neuroscience : the official journal of the Society for Neuroscience 2006;26(5):1551-61.
2006: Patrick K Safo; Benjamin F Cravatt; Wade G Regehr
Retrograde endocannabinoid signaling in the cerebellar cortex.
Cerebellum (London, England) 2006;5(2):134-45.
2006: Jennifer M Milner; Lara Kevorkian; David A Young; Debra Jones; Robin Wait; Simon T Donell; Emma Barksby; Angela M Patterson; Jim Middleton; Benjamin F Cravatt; et al.
Fibroblast activation protein alpha is expressed by chondrocytes following a pro-inflammatory stimulus and is elevated in osteoarthritis.
Arthritis research & therapy 2006;8(1):R23.
2005: Jessica P Alexander; Benjamin F Cravatt
Mechanism of carbamate inactivation of FAAH: implications for the design of covalent inhibitors and in vivo functional probes for enzymes.
Chemistry & biology 2005;12(11):1179-87.
2005: Elizabeth J Want; Benjamin F Cravatt; Gary Siuzdak
The expanding role of mass spectrometry in metabolite profiling and characterization.
Chembiochem : a European journal of chemical biology 2005;6(11):1941-51.
2005: Michael J Evans; Alan Saghatelian; Erik J Sorensen; Benjamin F Cravatt
Target discovery in small-molecule cell-based screens by in situ proteome reactivity profiling.
Nature biotechnology 2005;23(10):1303-7.
2005: Tania Aguado; Krisztina Monory; Javier Palazuelos; Nephi Stella; Benjamin Cravatt; Beat Lutz; Giovanni Marsicano; Zaal Kokaia; Manuel Guzmán; Ismael Galve-Roperh
The endocannabinoid system drives neural progenitor proliferation.
FASEB journal : official publication of the Federation of American Societies for Experimental Biology 2005;19(12):1704-6.
2005: Carmen Drahl; Benjamin F Cravatt; Erik J Sorensen
Protein-reactive natural products.
Angewandte Chemie (International ed. in English) 2005;44(36):5788-809.
2005: Edward D Högestätt; Bo A G Jönsson; Anna Ermund; David A Andersson; Henrik Björk; Jessica P Alexander; Benjamin F Cravatt; Allan I Basbaum; Peter M Zygmunt
Conversion of acetaminophen to the bioactive N-acylphenolamine AM404 via fatty acid amide hydrolase-dependent arachidonic acid conjugation in the nervous system.
The Journal of biological chemistry 2005;280(36):31405-12.
2005: Benjamin F Cravatt
Live chemical reports from the cell surface.
Chemistry & biology 2005;12(9):954-6; discussion 999-1006.
2005: Nadim Jessani; Sherry Niessen; BinQing Q Wei; Monica Nicolau; Mark Humphrey; Youngran Ji; Wonshik Han; Dong-Young Noh; John R Yates; Stefanie S Jeffrey; et al.
A streamlined platform for high-content functional proteomics of primary human specimens.
Nature methods 2005;2(9):691-7.
2005: Alan Saghatelian; Benjamin F Cravatt
Discovery metabolite profiling--forging functional connections between the proteome and metabolome.
Life sciences 2005;77(14):1759-66.
2005: Alan Saghatelian; Benjamin F Cravatt
Assignment of protein function in the postgenomic era.
Nature chemical biology 2005;1(3):130-42.
2005: Pál Pacher; Sándor Bátkai; Douglas Osei-Hyiaman; László Offertáler; Jie Liu; Judy Harvey-White; Attila Brassai; Zoltán Járai; Benjamin F Cravatt; George Kunos
Hemodynamic profile, responsiveness to anandamide, and baroreflex sensitivity of mice lacking fatty acid amide hydrolase.
American journal of physiology. Heart and circulatory physiology 2005;289(2):H533-41.
2005: Anna E Speers; Benjamin F Cravatt
A tandem orthogonal proteolysis strategy for high-content chemical proteomics.
Journal of the American Chemical Society 2005;127(28):10018-9.
2005: Benjamin F Cravatt
Kinase chemical genomics--a new rule for the exceptions.
Nature methods 2005;2(6):411-2.
2005: Aron H Lichtman; Benjamin F Cravatt
Food for thought: endocannabinoid modulation of lipogenesis.
The Journal of clinical investigation 2005;115(5):1130-3.
2005: Daniel K Nomura; Donmienne Leung; Kyle P Chiang; Gary B Quistad; Benjamin F Cravatt; John E Casida
A brain detoxifying enzyme for organophosphorus nerve poisons.
Proceedings of the National Academy of Sciences of the United States of America 2005;102(17):6195-200.
2005: Nadim Jessani; Jason A Young; Sandra L Diaz; Matthew P Patricelli; Ajit Varki; Benjamin F Cravatt
Class assignment of sequence-unrelated members of enzyme superfamilies by activity-based protein profiling.
Angewandte Chemie (International ed. in English) 2005;44(16):2400-3.
2005: Dale L Boger; Hiroshi Miyauchi; Wu Du; Christophe Hardouin; Robert A Fecik; Heng Cheng; Inkyu Hwang; Michael P Hedrick; Donmienne Leung; Orlando Acevedo; et al.
Discovery of a potent, selective, and efficacious class of reversible alpha-ketoheterocycle inhibitors of fatty acid amide hydrolase effective as analgesics.
Journal of medicinal chemistry 2005;48(6):1849-56.
2005: E P Go; J V Apon; G Luo; A Saghatelian; R H Daniels; V Sahi; R Dubrow; B F Cravatt; A Vertes; G Siuzdak
Desorption/ionization on silicon nanowires.
Analytical chemistry 2005;77(6):1641-6.
2005: Donmienne Leung; Wu Du; Christophe Hardouin; Heng Cheng; Inkyu Hwang; Benjamin F Cravatt; Dale L Boger
Discovery of an exceptionally potent and selective class of fatty acid amide hydrolase inhibitors enlisting proteome-wide selectivity screening: concurrent optimization of enzyme inhibitor potency and selectivity.
Bioorganic & medicinal chemistry letters 2005;15(5):1423-8.
2005: Sachin Patel; Benjamin F Cravatt; Cecilia J Hillard
Synergistic interactions between cannabinoids and environmental stress in the activation of the central amygdala.
Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology 2005;30(3):497-507.
2005: Alan Saghatelian; Benjamin F Cravatt
Global strategies to integrate the proteome and metabolome.
Current opinion in chemical biology 2005;9(1):62-8.
2005: Nadim Jessani; Sherry Niessen; Barbara M Mueller; Benjamin F Cravatt
Breast cancer cell lines grown in vivo: what goes in isn't always the same as what comes out.
Cell cycle (Georgetown, Tex.) 2005;4(2):253-5.
2005: Sachin Patel; Erica J Carrier; W-S Vanessa Ho; David J Rademacher; Sonya Cunningham; D Sudarshan Reddy; J R Falck; Benjamin F Cravatt; Cecilia J Hillard
The postmortal accumulation of brain N-arachidonylethanolamine (anandamide) is dependent upon fatty acid amide hydrolase activity.
Journal of lipid research 2005;46(2):342-9.
2005: Douglas Osei-Hyiaman; Michael Depetrillo; Judith Harvey-White; Anthony W Bannon; Benjamin F Cravatt; Michael J Kuhar; Ken Mackie; Miklós Palkovits; George Kunos
Cocaine- and amphetamine-related transcript is involved in the orexigenic effect of endogenous anandamide.
Neuroendocrinology 2005;81(4):273-82.
2005: Michele K McKinney; Benjamin F Cravatt
Structure and function of fatty acid amide hydrolase.
Annual review of biochemistry 2005;74():411-32.
2004: Stephan A Sieber; Tony S Mondala; Steven R Head; Benjamin F Cravatt
Microarray platform for profiling enzyme activities in complex proteomes.
Journal of the American Chemical Society 2004;126(48):15640-1.
2004: Alan Saghatelian; Sunia A Trauger; Elizabeth J Want; Edward G Hawkins; Gary Siuzdak; Benjamin F Cravatt
Assignment of endogenous substrates to enzymes by global metabolite profiling.
Biochemistry 2004;43(45):14332-9.
2004: Shahnaz C Azad; Krisztina Monory; Giovanni Marsicano; Benjamin F Cravatt; Beat Lutz; Walter Zieglgänsberger; Gerhard Rammes
Circuitry for associative plasticity in the amygdala involves endocannabinoid signaling.
The Journal of neuroscience : the official journal of the Society for Neuroscience 2004;24(44):9953-61.
2004: Katherine T Barglow; Benjamin F Cravatt
Discovering disease-associated enzymes by proteome reactivity profiling.
Chemistry & biology 2004;11(11):1523-31.
2004: Michaela Egertová; Gregory J Michael; Benjamin F Cravatt; Maurice R Elphick
Fatty acid amide hydrolase in brain ventricular epithelium: mutually exclusive patterns of expression in mouse and rat.
Journal of chemical neuroanatomy 2004;28(3):171-81.
2004: Aron H Lichtman; Donmienne Leung; Christopher C Shelton; Alan Saghatelian; Christophe Hardouin; Dale L Boger; Benjamin F Cravatt
Reversible inhibitors of fatty acid amide hydrolase that promote analgesia: evidence for an unprecedented combination of potency and selectivity.
The Journal of pharmacology and experimental therapeutics 2004;311(2):441-8.
2004: Benjamin F Cravatt; Aron H Lichtman
The endogenous cannabinoid system and its role in nociceptive behavior.
Journal of neurobiology 2004;61(1):149-60.
2004: Nadim Jessani; Mark Humphrey; W Hayes McDonald; Sherry Niessen; Kim Masuda; Beena Gangadharan; John R Yates; Barbara M Mueller; Benjamin F Cravatt
Carcinoma and stromal enzyme activity profiles associated with breast tumor growth in vivo.
Proceedings of the National Academy of Sciences of the United States of America 2004;101(38):13756-61.
2004: Kyle P Chiang; Alexandra L Gerber; Jack C Sipe; Benjamin F Cravatt
Reduced cellular expression and activity of the P129T mutant of human fatty acid amide hydrolase: evidence for a link between defects in the endocannabinoid system and problem drug use.
Human molecular genetics 2004;13(18):2113-9.
2004: Salvador Huitron-Resendiz; Manuel Sanchez-Alavez; Derek N Wills; Benjamin F Cravatt; Steven J Henriksen
Characterization of the sleep-wake patterns in mice lacking fatty acid amide hydrolase.
Sleep 2004;27(5):857-65.
2004: Benjamin F Cravatt; Alan Saghatelian; Edward G Hawkins; Angela B Clement; Michael H Bracey; Aron H Lichtman
Functional disassociation of the central and peripheral fatty acid amide signaling systems.
Proceedings of the National Academy of Sciences of the United States of America 2004;101(29):10821-6.
2004: Alan Saghatelian; Nadim Jessani; Arul Joseph; Mark Humphrey; Benjamin F Cravatt
Activity-based probes for the proteomic profiling of metalloproteases.
Proceedings of the National Academy of Sciences of the United States of America 2004;101(27):10000-5.
2004: Silvia Ortega-Gutiérrez; E Gregory Hawkins; Alma Viso; María L López-Rodríguez; Benjamin F Cravatt
Comparison of anandamide transport in FAAH wild-type and knockout neurons: evidence for contributions by both FAAH and the CB1 receptor to anandamide uptake.
Biochemistry 2004;43(25):8184-90.
2004: Michael H Bracey; Benjamin F Cravatt; Raymond C Stevens
Structural commonalities among integral membrane enzymes.
FEBS letters 2004;567(2-3):159-65.
2004: Aron H Lichtman; Christopher C Shelton; Tushar Advani; Benjamin F Cravatt
Mice lacking fatty acid amide hydrolase exhibit a cannabinoid receptor-mediated phenotypic hypoalgesia.
Pain 2004;109(3):319-27.
2004: Anna E Speers; Benjamin F Cravatt
Profiling enzyme activities in vivo using click chemistry methods.
Chemistry & biology 2004;11(4):535-46.
2004: Federico Massa; Giovanni Marsicano; Heike Hermann; Astrid Cannich; Krisztina Monory; Benjamin F Cravatt; Gian-Luca Ferri; Andrei Sibaev; Martin Storr; Beat Lutz
The endogenous cannabinoid system protects against colonic inflammation.
The Journal of clinical investigation 2004;113(8):1202-9.
2004: Allan Weber; Jinsong Ni; Kah-Hiing John Ling; Andrew Acheampong; Diane D-S Tang-Liu; Robert Burk; Benjamin F Cravatt; David Woodward
Formation of prostamides from anandamide in FAAH knockout mice analyzed by HPLC with tandem mass spectrometry.
Journal of lipid research 2004;45(4):757-63.
2004: Gregory C Adam; Jonathan Burbaum; John W Kozarich; Matthew P Patricelli; Benjamin F Cravatt
Mapping enzyme active sites in complex proteomes.
Journal of the American Chemical Society 2004;126(5):1363-8.
2004: Nadim Jessani; Benjamin F Cravatt
The development and application of methods for activity-based protein profiling.
Current opinion in chemical biology 2004;8(1):54-9.
2004: Anna E Speers; Benjamin F Cravatt
Chemical strategies for activity-based proteomics.
Chembiochem : a European journal of chemical biology 2004;5(1):41-7.
2003: Karen Kustedjo; Songpon Deechongkit; Jeffery W Kelly; Benjamin F Cravatt
Recombinant expression, purification, and comparative characterization of torsinA and its torsion dystonia-associated variant Delta E-torsinA.
Biochemistry 2003;42(51):15333-41.
2003: Gregory C Adam; Christopher D Vanderwal; Erik J Sorensen; Benjamin F Cravatt
(-)-FR182877 is a potent and selective inhibitor of carboxylesterase-1.
Angewandte Chemie (International ed. in English) 2003;42(44):5480-4.
2003: Jie Liu; Sándor Batkai; Pál Pacher; Judith Harvey-White; Jens A Wagner; Benjamin F Cravatt; Bin Gao; George Kunos
Lipopolysaccharide induces anandamide synthesis in macrophages via CD14/MAPK/phosphoinositide 3-kinase/NF-kappaB independently of platelet-activating factor.
The Journal of biological chemistry 2003;278(45):45034-9.
2003: Michele K McKinney; Benjamin F Cravatt
Evidence for distinct roles in catalysis for residues of the serine-serine-lysine catalytic triad of fatty acid amide hydrolase.
The Journal of biological chemistry 2003;278(39):37393-9.
2003: Benjamin F Cravatt; Aron H Lichtman
Fatty acid amide hydrolase: an emerging therapeutic target in the endocannabinoid system.
Current opinion in chemical biology 2003;7(4):469-75.
2003: Donmienne Leung; Christophe Hardouin; Dale L Boger; Benjamin F Cravatt
Discovering potent and selective reversible inhibitors of enzymes in complex proteomes.
Nature biotechnology 2003;21(6):687-91.
2003: Angela B Clement; E Gregory Hawkins; Aron H Lichtman; Benjamin F Cravatt
Increased seizure susceptibility and proconvulsant activity of anandamide in mice lacking fatty acid amide hydrolase.
The Journal of neuroscience : the official journal of the Society for Neuroscience 2003;23(9):3916-23.
2003: Anna E Speers; Gregory C Adam; Benjamin F Cravatt
Activity-based protein profiling in vivo using a copper(i)-catalyzed azide-alkyne [3 + 2] cycloaddition.
Journal of the American Chemical Society 2003;125(16):4686-7.
2003: M Egertová; B F Cravatt; M R Elphick
Comparative analysis of fatty acid amide hydrolase and cb(1) cannabinoid receptor expression in the mouse brain: evidence of a widespread role for fatty acid amide hydrolase in regulation of endocannabinoid signaling.
Neuroscience 2003;119(2):481-96.
2002: Benjamin F Cravatt; Aron H Lichtman
The enzymatic inactivation of the fatty acid amide class of signaling lipids.
Chemistry and physics of lipids 2002;121(1-2):135-48.
2002: Ruedi Aebersold; Benjamin F Cravatt
Proteomics--advances, applications and the challenges that remain.
Trends in biotechnology 2002;20(12 Suppl):S1-2.
2002: Michael H Bracey; Michael A Hanson; Kim R Masuda; Raymond C Stevens; Benjamin F Cravatt
Structural adaptations in a membrane enzyme that terminates endocannabinoid signaling.
Science (New York, N.Y.) 2002;298(5599):1793-6.
2002: Gregory C Adam; Erik J Sorensen; Benjamin F Cravatt
Trifunctional chemical probes for the consolidated detection and identification of enzyme activities from complex proteomes.
Molecular & cellular proteomics : MCP 2002;1(10):828-35.
2002: Gregory C Adam; Erik J Sorensen; Benjamin F Cravatt
Chemical strategies for functional proteomics.
Molecular & cellular proteomics : MCP 2002;1(10):781-90.
2002: Nadim Jessani; Yongsheng Liu; Mark Humphrey; Benjamin F Cravatt
Enzyme activity profiles of the secreted and membrane proteome that depict cancer cell invasiveness.
Proceedings of the National Academy of Sciences of the United States of America 2002;99(16):10335-40.
2002: Gregory C Adam; Erik J Sorensen; Benjamin F Cravatt
Proteomic profiling of mechanistically distinct enzyme classes using a common chemotype.
Nature biotechnology 2002;20(8):805-9.
2002: Aron H Lichtman; E Gregory Hawkins; Graeme Griffin; Benjamin F Cravatt
Pharmacological activity of fatty acid amides is regulated, but not mediated, by fatty acid amide hydrolase in vivo.
The Journal of pharmacology and experimental therapeutics 2002;302(1):73-9.
2002: Jack C Sipe; Kyle Chiang; Alexandra L Gerber; Ernest Beutler; Benjamin F Cravatt
A missense mutation in human fatty acid amide hydrolase associated with problem drug use.
Proceedings of the National Academy of Sciences of the United States of America 2002;99(12):8394-9.
2001: S Huitrón-Reséndiz; L Gombart; B F Cravatt; S J Henriksen
Effect of oleamide on sleep and its relationship to blood pressure, body temperature, and locomotor activity in rats.
Experimental neurology 2001;172(1):235-43.
2001: B F Cravatt; K Demarest; M P Patricelli; M H Bracey; D K Giang; B R Martin; A H Lichtman
Supersensitivity to anandamide and enhanced endogenous cannabinoid signaling in mice lacking fatty acid amide hydrolase.
Proceedings of the National Academy of Sciences of the United States of America 2001;98(16):9371-6.
2001: M P Patricelli; B F Cravatt
Characterization and manipulation of the acyl chain selectivity of fatty acid amide hydrolase.
Biochemistry 2001;40(20):6107-15.
2001: D Kidd; Y Liu; B F Cravatt
Profiling serine hydrolase activities in complex proteomes.
Biochemistry 2001;40(13):4005-15.
2001: M P Patricelli; B F Cravatt
Proteins regulating the biosynthesis and inactivation of neuromodulatory fatty acid amides.
Vitamins and hormones 2001;62():95-131.
2000: D L Boger; R A Fecik; J E Patterson; H Miyauchi; M P Patricelli; B F Cravatt
Fatty acid amide hydrolase substrate specificity.
Bioorganic & medicinal chemistry letters 2000;10(23):2613-6.
2000: B F Cravatt; E J Sorensen
Chemical strategies for the global analysis of protein function.
Current opinion in chemical biology 2000;4(6):663-8.
2000: K Kustedjo; M H Bracey; B F Cravatt
Torsin A and its torsion dystonia-associated mutant forms are lumenal glycoproteins that exhibit distinct subcellular localizations.
The Journal of biological chemistry 2000;275(36):27933-9.
2000: E W Wang; B M Kessler; A Borodovsky; B F Cravatt; M Bogyo; H L Ploegh; R Glas
Integration of the ubiquitin-proteasome pathway with a cytosolic oligopeptidase activity.
Proceedings of the National Academy of Sciences of the United States of America 2000;97(18):9990-5.
2000: M P Patricelli; B F Cravatt
Clarifying the catalytic roles of conserved residues in the amidase signature family.
The Journal of biological chemistry 2000;275(25):19177-84.
2000: D L Boger; H Sato; A E Lerner; M P Hedrick; R A Fecik; H Miyauchi; G D Wilkie; B J Austin; M P Patricelli; B F Cravatt
Exceptionally potent inhibitors of fatty acid amide hydrolase: the enzyme responsible for degradation of endogenous oleamide and anandamide.
Proceedings of the National Academy of Sciences of the United States of America 2000;97(10):5044-9.
2000: M Egertová; B F Cravatt; M R Elphick
Fatty acid amide hydrolase expression in rat choroid plexus: possible role in regulation of the sleep-inducing action of oleamide.
Neuroscience letters 2000;282(1-2):13-6.
1999: Y Liu; M P Patricelli; B F Cravatt
Activity-based protein profiling: the serine hydrolases.
Proceedings of the National Academy of Sciences of the United States of America 1999;96(26):14694-9.
1999: M P Patricelli; B F Cravatt
Fatty acid amide hydrolase competitively degrades bioactive amides and esters through a nonconventional catalytic mechanism.
Biochemistry 1999;38(43):14125-30.
1999: M P Patricelli; M A Lovato; B F Cravatt
Chemical and mutagenic investigations of fatty acid amide hydrolase: evidence for a family of serine hydrolases with distinct catalytic properties.
Biochemistry 1999;38(31):9804-12.
1999: E A Thomas; B F Cravatt; J G Sutcliffe
The endogenous lipid oleamide activates serotonin 5-HT7 neurons in mouse thalamus and hypothalamus.
Journal of neurochemistry 1999;72(6):2370-8.
1999: D L Boger; H Sato; A E Lerner; B J Austin; J E Patterson; M P Patricelli; B F Cravatt
Trifluoromethyl ketone inhibitors of fatty acid amide hydrolase: a probe of structural and conformational features contributing to inhibition.
Bioorganic & medicinal chemistry letters 1999;9(2):265-70.
1998: M Egertová; D K Giang; B F Cravatt; M R Elphick
A new perspective on cannabinoid signalling: complementary localization of fatty acid amide hydrolase and the CB1 receptor in rat brain.
Proceedings. Biological sciences / The Royal Society 1998;265(1410):2081-5.
1998: M P Patricelli; H A Lashuel; D K Giang; J W Kelly; B F Cravatt
Comparative characterization of a wild type and transmembrane domain-deleted fatty acid amide hydrolase: identification of the transmembrane domain as a site for oligomerization.
Biochemistry 1998;37(43):15177-87.
1998: D L Boger; S J Henriksen; B F Cravatt
Oleamide: an endogenous sleep-inducing lipid and prototypical member of a new class of biological signaling molecules.
Current pharmaceutical design 1998;4(4):303-14.
1998: D L Boger; J E Patterson; X Guan; B F Cravatt; R A Lerner; N B Gilula
Chemical requirements for inhibition of gap junction communication by the biologically active lipid oleamide.
Proceedings of the National Academy of Sciences of the United States of America 1998;95(9):4810-5.
1998: D K Giang; B F Cravatt
A second mammalian N-myristoyltransferase.
The Journal of biological chemistry 1998;273(12):6595-8.
1998: M P Patricelli; J E Patterson; D L Boger; B F Cravatt
An endogenous sleep-inducing compound is a novel competitive inhibitor of fatty acid amide hydrolase.
Bioorganic & medicinal chemistry letters 1998;8(6):613-8.
1997: X Guan; B F Cravatt; G R Ehring; J E Hall; D L Boger; R A Lerner; N B Gilula
The sleep-inducing lipid oleamide deconvolutes gap junction communication and calcium wave transmission in glial cells.
The Journal of cell biology 1997;139(7):1785-92.
1997: E A Thomas; B F Cravatt; P E Danielson; N B Gilula; J G Sutcliffe
Fatty acid amide hydrolase, the degradative enzyme for anandamide and oleamide, has selective distribution in neurons within the rat central nervous system.
Journal of neuroscience research 1997;50(6):1047-52.
1997: D K Giang; B F Cravatt
Molecular characterization of human and mouse fatty acid amide hydrolases.
Proceedings of the National Academy of Sciences of the United States of America 1997;94(6):2238-42.
1996: B F Cravatt; D K Giang; S P Mayfield; D L Boger; R A Lerner; N B Gilula
Molecular characterization of an enzyme that degrades neuromodulatory fatty-acid amides.
Nature 1996;384(6604):83-7.
1995: B F Cravatt; O Prospero-Garcia; G Siuzdak; N B Gilula; S J Henriksen; D L Boger; R A Lerner
Chemical characterization of a family of brain lipids that induce sleep.
Science (New York, N.Y.) 1995;268(5216):1506-9.
1994: R A Lerner; G Siuzdak; O Prospero-Garcia; S J Henriksen; D L Boger; B F Cravatt
Cerebrodiene: a brain lipid isolated from sleep-deprived cats.
Proceedings of the National Academy of Sciences of the United States of America 1994;91(20):9505-8.

Benjamin Cravatt

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