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Fiona Crawford

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Alzheimer's Disease

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Joseph-Olubunmi Ojo; Corbin J Bachmeier; M Banks Greenberg; Benoit Mouzon; Mike Mullan; Fiona Crawford
Repetitive mild traumatic brain injury augments tau pathology and glial activation in aged hTau mice.
Corbin J Bachmeier; David Beaulieu-Abdelahad; Fiona Crawford; Michael Mullan; Daniel Paris
Stimulation of the retinoid X receptor facilitates beta-amyloid clearance across the blood-brain barrier.
Daniel Paris; Jon Reed; Megha Verma; Laila Abdullah; Ghania Ait-Ghezala; Corbin J Bachmeier; David Beaulieu-Abdelahad; Fiona Crawford; Michael Mullan
Anti-inflammatory activity of anatabine via inhibition of STAT3 phosphorylation.

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All Publications

2013: Joseph-Olubunmi Ojo; Corbin J Bachmeier; M Banks Greenberg; Benoit Mouzon; Mike Mullan; Fiona Crawford
Repetitive mild traumatic brain injury augments tau pathology and glial activation in aged hTau mice.
Journal of neuropathology and experimental neurology 2013;72(2):137-51.
2013: Corbin J Bachmeier; David Beaulieu-Abdelahad; Fiona Crawford; Michael Mullan; Daniel Paris
Stimulation of the retinoid X receptor facilitates beta-amyloid clearance across the blood-brain barrier.
Journal of molecular neuroscience : MN 2013;49(2):270-6.
2013: Daniel Paris; Jon Reed; Megha Verma; Laila Abdullah; Ghania Ait-Ghezala; Corbin J Bachmeier; David Beaulieu-Abdelahad; Fiona Crawford; Michael Mullan
Anti-inflammatory activity of anatabine via inhibition of STAT3 phosphorylation.
European journal of pharmacology 2013;698(1-3):145-53.
2013: Daniel Paris; Ghania Ait-Ghezala; Corbin J Bachmeier; David Beaulieu-Abdelahad; Fiona Crawford; Venkatarajan S Mathura; Myles Mullan; Michael Mullan
Amelioration of experimental autoimmune encephalomyelitis by anatabine.
PloS one 2013;8(1):e55392.
2013: Corbin J Bachmeier; David Beaulieu-Abdelahad; Benoit Mouzon; Michael Mullan; Daniel Paris; Fiona Crawford
A multifaceted role for apoE in the clearance of beta-amyloid across the blood-brain barrier.
Neuro-degenerative diseases 2013;11(1):13-21.
2012: Benoit Mouzon; Michael Mullan; Janice Stewart; William Stewart; Corbin J Bachmeier; Helena Chaytow; Gogce Crynen; Fiona Crawford
Repetitive mild traumatic brain injury in a mouse model produces learning and memory deficits accompanied by histological changes.
Journal of neurotrauma 2012;29(18):2761-73.
2012: Sean Kennelly; Rose Anne Kenny; Laila Abdullah; Fiona Crawford; Cheryl A Luis; Venkatarajan S Mathura; Benoit Mouzon; Michael Mullan; Brian Lawlor
Apolipoprotein E genotype-specific short-term cognitive benefits of treatment with the antihypertensive nilvadipine in Alzheimer's patients--an open-label trial.
International journal of geriatric psychiatry 2012;27(4):415-22.
2011: Laila Abdullah; Ghania Ait-Ghezala; Alex Bishop; Gogce Crynen; Scott Ferguson; Venkatarajan S Mathura; Benoit Mouzon; Myles Mullan; Michael Mullan; John Phillips; Jon Reed; Fiona Crawford
Proteomic CNS profile of delayed cognitive impairment in mice exposed to Gulf War agents.
Neuromolecular medicine 2011;13(4):275-88.
2011: Daniel Paris; Jon Reed; Ghania Ait-Ghezala; Corbin J Bachmeier; David Beaulieu-Abdelahad; Alex Bishop; Jin Chao; Fiona Crawford; Venkat Mathura; Michael Mullan
Anatabine lowers Alzheimer's Aβ production in vitro and in vivo.
European journal of pharmacology 2011;670(2-3):384-91.
2011: Daniel Paris; Corbin J Bachmeier; Nikunj Patel; Amita Quadros; Claude-Henry Volmar; Vincent Laporte; Jim Ganey; David Beaulieu-Abdelahad; Ghania Ait-Ghezala; Fiona Crawford; Michael Mullan
Selective antihypertensive dihydropyridines lower Aβ accumulation by targeting both the production and the clearance of Aβ across the blood-brain barrier.
Molecular medicine (Cambridge, Mass.) 2011;17(3-4):149-62.
2011: Cheryl A Luis; Benoit Mouzon; Laila Abdullah; Ghania Ait-Ghezala; Fiona Crawford; Andrew P Keegan; Michael Mullan
Feasibility of Predicting MCI/AD Using Neuropsychological Tests and Serum β-Amyloid.
International journal of Alzheimer's disease 2011;2011():786264.
2010: S Ferguson; B Mouzon; G Kayihan; M Wood; F Poon; S Doore; Venkatarajan S Mathura; James Humphrey; B O'Steen; R Hayes; Allen D Roses; Michael Mullan; Fiona Crawford
Apolipoprotein E genotype and oxidative stress response to traumatic brain injury.
Neuroscience 2010;168(3):811-9.
2009: Fiona Crawford; M Wood; S Ferguson; Venkatarajan S Mathura; P Gupta; James Humphrey; B Mouzon; V Laporte; E Margenthaler; B O'Steen; R Hayes; Allen D Roses; Michael Mullan
Apolipoprotein E-genotype dependent hippocampal and cortical responses to traumatic brain injury.
Neuroscience 2009;159(4):1349-62.
2009: Cheryl A Luis; Laila Abdullah; Daniel Paris; Amita Quadros; Michael Mullan; Benoit Mouzon; Ghania Ait-Ghezala; Fiona Crawford; Michael Mullan
Serum beta-amyloid correlates with neuropsychological impairment.
Neuropsychology, development, and cognition. Section B, Aging, neuropsychology and cognition 2009;16(2):203-18.
2007: Laila Abdullah; Daniel Paris; Cheryl Luis; Amita Quadros; Julia Parrish; Luis Valdes; Andrew P Keegan; Venkatarajan S Mathura; Fiona Crawford; Michael Mullan
The influence of diagnosis, intra- and inter-person variability on serum and plasma Abeta levels.
Neuroscience letters 2007;428(2-3):53-8.
2006: Laila Abdullah; Ghania Ait-Ghezala; Fiona Crawford; Timothy A Crowell; Warren W Barker; Ranjan Duara; Michael Mullan
The cyclooxygenase 2 -765 C promoter allele is a protective factor for Alzheimer's disease.
Neuroscience letters 2006;395(3):240-3.
2005: Ghania Ait-Ghezala; Venkatarajan S Mathura; Vincent Laporte; Amita Quadros; Daniel Paris; Nikunj Patel; Claude-Henry Volmar; Deepak Kolippakkam; Fiona Crawford; Michael Mullan
Genomic regulation after CD40 stimulation in microglia: relevance to Alzheimer's disease.
Brain research. Molecular brain research 2005;140(1-2):73-85.
2004: J Todd Roach; Claude-Henry Volmar; Samvid Dwivedi; Terrence Town; Robert Crescentini; Fiona Crawford; Jun Tan; Michael Mullan
Behavioral effects of CD40-CD40L pathway disruption in aged PSAPP mice.
Brain research 2004;1015(1-2):161-8.
2004: Daniel Paris; Amita Quadros; James Humphrey; Nikunj Patel; Robert Crescentini; Fiona Crawford; Michael Mullan
Nilvadipine antagonizes both Abeta vasoactivity in isolated arteries, and the reduced cerebral blood flow in APPsw transgenic mice.
Brain research 2004;999(1):53-61.
2004: Daniel Paris; Kirk Townsend; Amita Quadros; James Humphrey; Jiazhi Sun; Steven Brem; Marguerite Wotoczek-Obadia; Anthony DelleDonne; Nikunj Patel; Demian Obregon; Robert Crescentini; Laila Abdullah; Domenico Coppola; Amyn M Rojiani; Fiona Crawford; Said M Sebti; Michael Mullan
Inhibition of angiogenesis by Abeta peptides.
Angiogenesis 2004;7(1):75-85.
2003: Amita Quadros; Nikunj Patel; Robert Crescentini; Fiona Crawford; Daniel Paris; Michael Mullan
Increased TNFalpha production and Cox-2 activity in organotypic brain slice cultures from APPsw transgenic mice.
Neuroscience letters 2003;353(1):66-8.
2003: Daniel Paris; James Humphrey; Amita Quadros; Nikunj Patel; Robert Crescentini; Fiona Crawford; Michael Mullan
Vasoactive effects of A beta in isolated human cerebrovessels and in a transgenic mouse model of Alzheimer's disease: role of inflammation.
Neurological research 2003;25(6):642-51.
2002: Jun Tan; Terrence Town; Fiona Crawford; Takashi Mori; Anthony DelleDonne; Robert Crescentini; Demian Obregon; Richard A Flavell; Michael Mullan
Role of CD40 ligand in amyloidosis in transgenic Alzheimer's mice.
Nature neuroscience 2002;5(12):1288-93.
2002: Jun Tan; Terrence Town; Laila Abdullah; Yajaun Wu; Andon Placzek; Brent Small; Jodi Kroeger; Fiona Crawford; Dan Richards; Michael Mullan
CD45 isoform alteration in CD4+ T cells as a potential diagnostic marker of Alzheimer's disease.
Journal of neuroimmunology 2002;132(1-2):164-72.
2002: Terrence Town; Martina Vendrame; Anant Patel; Daniel Poetter; Anthony DelleDonne; Takashi Mori; Robert Smeed; Fiona Crawford; Thomas Klein; Jun Tan; Michael Mullan
Reduced Th1 and enhanced Th2 immunity after immunization with Alzheimer's beta-amyloid(1-42).
Journal of neuroimmunology 2002;132(1-2):49-59.
2002: Ghania Ait-Ghezala; Laila Abdullah; Robert Crescentini; Fiona Crawford; Terrence Town; S Singh; D Richards; Ranjan Duara; Michael Mullan
Confirmation of association between D10S583 and Alzheimer's disease in a case--control sample.
Neuroscience letters 2002;325(2):87-90.
2002: Jun Tan; Terrence Town; Takashi Mori; Demian Obregon; Yajuan Wu; Anthony DelleDonne; Amyn M Rojiani; Fiona Crawford; Richard A Flavell; Michael Mullan
CD40 is expressed and functional on neuronal cells.
The EMBO journal 2002;21(4):643-52.
2001: Takashi Mori; Daniel Paris; Terrence Town; Amyn M Rojiani; D Larry Sparks; Anthony DelleDonne; Fiona Crawford; Laila Abdullah; J A Humphrey; dennis dickson; Michael Mullan
Cholesterol accumulates in senile plaques of Alzheimer disease patients and in transgenic APP(SW) mice.
Journal of neuropathology and experimental neurology 2001;60(8):778-85.
2000: Jun Tan; Terrence Town; Takashi Mori; Y Wu; M Saxe; Fiona Crawford; Michael Mullan
CD45 opposes beta-amyloid peptide-induced microglial activation via inhibition of p44/42 mitogen-activated protein kinase.
The Journal of neuroscience : the official journal of the Society for Neuroscience 2000;20(20):7587-94.
2000: Fiona Crawford; Laila Abdullah; John A Schinka; Z Suo; M Gold; Ranjan Duara; Michael Mullan
Gender-specific association of the angiotensin converting enzyme gene with Alzheimer's disease.
Neuroscience letters 2000;280(3):215-9.
2000: Steven Sevush; G Peruyera; Fiona Crawford; Michael Mullan
Apolipoprotein-E epsilon 4 allele frequency and conferred risk for Cuban Americans with Alzheimer's disease.
The American journal of geriatric psychiatry : official journal of the American Association for Geriatric Psychiatry 2000;8(3):254-6.
1999: Jun Tan; Terrence Town; Daniel Paris; T Mori; Z Suo; Fiona Crawford; Mark P Mattson; R A Flavell; Michael Mullan
Microglial activation resulting from CD40-CD40L interaction after beta-amyloid stimulation.
Science (New York, N.Y.) 1999;286(5448):2352-5.
1999: Terrence Town; Daniel Paris; T A Parker; A Kundtz; Jun Tan; Ranjan Duara; M Gold; Fiona Crawford; Michael Mullan
Alzheimers disease is not associated with the hypertension genetic risk factors PLA(2) or G protein beta3, either independently or interactively with apolipoprotein E.
American journal of medical genetics 1999;88(5):465-8.
1999: Terrence Town; Laila Abdullah; Fiona Crawford; John A Schinka; Patricia Isbell Ordorica; E Francis; P Hughes; Ranjan Duara; Michael Mullan
Association of a functional mu-opioid receptor allele (+118A) with alcohol dependency.
American journal of medical genetics 1999;88(5):458-61.
1999: Jun Tan; Terrence Town; Z Suo; Y Wu; S Song; A Kundtz; J Kroeger; James Humphrey; Fiona Crawford; Michael Mullan
Induction of CD40 on human endothelial cells by Alzheimer's beta-amyloid peptides.
Brain research bulletin 1999;50(2):143-8.
1999: Fiona Crawford; Terrence Town; M Freeman; John A Schinka; M Gold; Ranjan Duara; Michael Mullan
The alpha-2 macroglobulin gene is not associated with Alzheimer's disease in a case-control sample.
Neuroscience letters 1999;270(3):133-6.
1999: Jun Tan; Terrence Town; Daniel Paris; Andon Placzek; T Parker; Fiona Crawford; H Yu; James Humphrey; Michael Mullan
Activation of microglial cells by the CD40 pathway: relevance to multiple sclerosis.
Journal of neuroimmunology 1999;97(1-2):77-85.
1999: Fiona Crawford; M Freeman; Terrence Town; D Fallin; M Gold; Ranjan Duara; Michael Mullan
No genetic association between polymorphisms in the Tau gene and Alzheimer's disease in clinic or population based samples.
Neuroscience letters 1999;266(3):193-6.
1999: Daniel Paris; Terrence Town; TA Parker; Jun Tan; James Humphrey; Fiona Crawford; Michael Mullan
Inhibition of Alzheimer's beta-amyloid induced vasoactivity and proinflammatory response in microglia by a cGMP-dependent mechanism.
Experimental neurology 1999;157(1):211-21.
1998: Z Suo; James Humphrey; A Kundtz; F Sethi; Andon Placzek; Fiona Crawford; Michael Mullan
Soluble Alzheimers beta-amyloid constricts the cerebral vasculature in vivo.
Neuroscience letters 1998;257(2):77-80.
1998: Fiona Crawford; C Soto; Z Suo; C Fang; T Parker; A Sawar; Blas Frangione; Michael Mullan
Alzheimer's beta-amyloid vasoactivity: identification of a novel beta-amyloid conformational intermediate.
FEBS letters 1998;436(3):445-8.
1998: Z Suo; Jun Tan; Andon Placzek; Fiona Crawford; C Fang; Michael Mullan
Alzheimer's beta-amyloid peptides induce inflammatory cascade in human vascular cells: the roles of cytokines and CD40.
Brain research 1998;807(1-2):110-7.
1998: Terrence Town; Daniel Paris; D Fallin; Ranjan Duara; W Barker; M Gold; Fiona Crawford; Michael Mullan
The -491A/T apolipoprotein E promoter polymorphism association with Alzheimer's disease: independent risk and linkage disequilibrium with the known APOE polymorphism.
Neuroscience letters 1998;252(2):95-8.
1998: Daniel Paris; TA Parker; Terrence Town; Z Suo; C Fang; James Humphrey; Fiona Crawford; Michael Mullan
Role of peroxynitrite in the vasoactive and cytotoxic effects of Alzheimer's beta-amyloid1-40 peptide.
Experimental neurology 1998;152(1):116-22.
1998: Fiona Crawford; D Fallin; Z Suo; Laila Abdullah; M Gold; AC Gauntlett; Ranjan Duara; Michael Mullan
The butyrylcholinesterase gene is neither independently nor synergistically associated with late-onset AD in clinic- and community-based populations.
Neuroscience letters 1998;249(2-3):115-8.
1998: Fiona Crawford; Z Suo; C Fang; Michael Mullan
Characteristics of the in vitro vasoactivity of beta-amyloid peptides.
Experimental neurology 1998;150(1):159-68.
1997: Fiona Crawford; Z Suo; C Fang; A Sawar; G Su; Gary W Arendash; Michael Mullan
The vasoactivity of A beta peptides.
Annals of the New York Academy of Sciences 1997;826():35-46.
1997: D Fallin; A Kundtz; Terrence Town; AC Gauntlett; Ranjan Duara; W Barker; Fiona Crawford; Michael Mullan
No association between the low density lipoprotein receptor-related protein (LRP) gene and late-onset Alzheimer's disease in a community-based sample.
Neuroscience letters 1997;233(2-3):145-7.
1997: Terrence Town; D Fallin; Fiona Crawford; S Walsh; R Solomon; Michael Mullan
Lack of association between the apolipoprotein E epsilon4 allele (APOE epsilon4) and chronic schizophrenia.
American journal of medical genetics 1997;74(4):451-2.
1997: X Cai; D Fallin; J Stanton; P Scibelli; Ranjan Duara; Fiona Crawford; Michael Mullan
APOE is linked to Alzheimer's disease in a large pedigree.
American journal of medical genetics 1997;74(4):365-9.
1997: Z Suo; C Fang; Fiona Crawford; Michael Mullan
Superoxide free radical and intracellular calcium mediate A beta(1-42) induced endothelial toxicity.
Brain research 1997;762(1-2):144-52.
1997: X Cai; J Stanton; D Fallin; J Hoyne; Ranjan Duara; M Gold; Steven Sevush; P Scibelli; Fiona Crawford; Michael Mullan
No association between the intronic presenilin-1 polymorphism and Alzheimer's disease in clinic and population-based samples.
American journal of medical genetics 1997;74(2):202-3.
1997: D Fallin; S Reading; J Schinka; J Hoyne; P Scibelli; M Gold; Fiona Crawford; Michael Mullan
No interaction between the APOE and the alpha-1-antichymotrypsin genes on risk for Alzheimer's disease.
American journal of medical genetics 1997;74(2):192-4.
1997: D Fallin; AC Gauntlett; P Scibelli; X Cai; Ranjan Duara; M Gold; Fiona Crawford; Michael Mullan
No association between the very low density lipoprotein receptor gene and late-onset Alzheimer's disease nor interaction with the apolipoprotein E gene in population-based and clinic samples.
Genetic epidemiology 1997;14(3):299-305.
1996: Michael Mullan; P Scibelli; Ranjan Duara; D Fallin; M Gold; John A Schinka; J Hoyne; A Osborne; Steven Sevush; Fiona Crawford
Familial and population-based studies of apolipoprotein E and Alzheimer's disease.
Annals of the New York Academy of Sciences 1996;802():16-26.
1996: Fiona Crawford; J Hoyne; X Cai; A Osborne; D Poston; J Zaglul; N Dajani; S Walsh; R Bradley; R Solomon; Michael Mullan
Dopamine DRD2/Cys311 is not associated with chronic schizophrenia.
American journal of medical genetics 1996;67(5):483-4.
1995: Fiona Crawford; J Hoyne; P Diaz; A Osborne; J Dorotheo; D Sheehan; Michael Mullan
Occurrence of the Cys311 DRD2 variant in a pedigree multiply affected with panic disorder.
American journal of medical genetics 1995;60(4):332-4.
1995: C Bennett; Fiona Crawford; A Osborne; P Diaz; J Hoyne; Roberto Lopez; P Roques; Ranjan Duara; Martin N Rossor; Michael Mullan
Evidence that the APOE locus influences rate of disease progression in late onset familial Alzheimer's Disease but is not causative.
American journal of medical genetics 1995;60(1):1-6.
1994: Michael Mullan; Fiona Crawford
The molecular genetics of Alzheimer's disease.
Molecular neurobiology 1994;9(1-3):15-22.
1994: Michael Mullan; Fiona Crawford; J Buchanan
Technical feasibility of genetic testing for Alzheimer's disease.
Alzheimer disease and associated disorders 1994;8(2):102-15.
1993: Michael Mullan; Henry Houlden; Fiona Crawford; A Kennedy; P Rogues; Martin N Rossor
Age of onset in familial early onset Alzheimer's disease correlates with genetic aetiology.
American journal of medical genetics 1993;48(3):129-30.
1993: Henry Houlden; Fiona Crawford; Martin N Rossor; Michael Mullan
Screening for the APP codon 670/671 mutations in Alzheimer's disease.
Neuroscience letters 1993;154(1-2):161-2.
1992: Fiona Crawford; Alison Goate
Alzheimer's disease untangled.
BioEssays : news and reviews in molecular, cellular and developmental biology 1992;14(11):727-34.
1992: Rosa Adroer; Marie-Christine Chartier-Harlin; Fiona Crawford; Rafael Oliva
Improved direct sequencing of Alzheimer's amyloid precursor protein (APP) exons 16 and 17.
Neuroscience letters 1992;141(1):69-71.
1992: Fiona Crawford; Marie-Christine Chartier-Harlin; Michael Mullan; John Hardy; André Delacourte; G Arnott
Alzheimer's--a correction.
Nature 1992;356(6368):390.
1991: Fiona Crawford; John Hardy; Michael Mullan; Alison Goate; D Hughes; L Fidani; P Roques; Martin N Rossor; Marie-Christine Chartier-Harlin
Sequencing of exons 16 and 17 of the beta-amyloid precursor protein gene in 14 families with early onset Alzheimer's disease fails to reveal mutations in the beta-amyloid sequence.
Neuroscience letters 1991;133(1):1-2.
1991: Marie-Christine Chartier-Harlin; Fiona Crawford; Henry Houlden; AC Warren; D Hughes; L Fidani; Alison Goate; Martin N Rossor; P Roques; John Hardy
Early-onset Alzheimer's disease caused by mutations at codon 717 of the beta-amyloid precursor protein gene.
Nature 1991;353(6347):844-6.
1991: Marie-Christine Chartier-Harlin; Fiona Crawford; K Hamandi; Michael Mullan; Alison Goate; John Hardy; Hubert Backhovens; J J Martin; Christine Van Broeckhoven
Screening for the beta-amyloid precursor protein mutation (APP717: Val----Ile) in extended pedigrees with early onset Alzheimer's disease.
Neuroscience letters 1991;129(1):134-5.
1991: Alison Goate; Marie-Christine Chartier-Harlin; Michael Mullan; J Brown; Fiona Crawford; L Fidani; L Giuffra; A Haynes; N Irving; L James
Segregation of a missense mutation in the amyloid precursor protein gene with familial Alzheimer's disease.
Nature 1991;349(6311):704-6.