Gunnar Alm

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Lood Christian; Gullstrand Birgitta; Truedsson Lennart; Olin Anders I; Alm Gunnar V; Rönnblom Lars; Sturfelt Gunnar; Eloranta Maija-Leena; Bengtsson Anders A
C1q inhibits immune complex-induced interferon-alpha production in plasmacytoid dendritic cells: a novel link between C1q deficiency and systemic lupus erythematosus pathogenesis.
Rönnblom Lars; Alm Gunnar V; Eloranta Maija-Leena
Type I interferon and lupus.
Eloranta Maija-Leena; Lövgren Tanja; Finke Doreen; Mathsson Linda; Rönnelid Johan; Kastner Berthold; Alm Gunnar V; Rönnblom Lars
Regulation of the interferon-alpha production induced by RNA-containing immune complexes in plasmacytoid dendritic cells.

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2009: Lood Christian; Gullstrand Birgitta; Truedsson Lennart; Olin Anders I; Alm Gunnar V; Rönnblom Lars; Sturfelt Gunnar; Eloranta Maija-Leena; Bengtsson Anders A
C1q inhibits immune complex-induced interferon-alpha production in plasmacytoid dendritic cells: a novel link between C1q deficiency and systemic lupus erythematosus pathogenesis.
Arthritis and rheumatism 2009;60(10):3081-90.
2009: Rönnblom Lars; Alm Gunnar V; Eloranta Maija-Leena
Type I interferon and lupus.
Current opinion in rheumatology 2009;21(5):471-7.
2009: Eloranta Maija-Leena; Lövgren Tanja; Finke Doreen; Mathsson Linda; Rönnelid Johan; Kastner Berthold; Alm Gunnar V; Rönnblom Lars
Regulation of the interferon-alpha production induced by RNA-containing immune complexes in plasmacytoid dendritic cells.
Arthritis and rheumatism 2009;60(8):2418-27.
2009: Nordmark G; Kristjansdottir G; Theander E; Eriksson P; Brun J G; Wang C; Padyukov L; Truedsson L; Alm G; Eloranta M-L; Jonsson R; Rönnblom L; Syvänen A-C
Additive effects of the major risk alleles of IRF5 and STAT4 in primary Sjögren's syndrome.
Genes and immunity 2009;10(1):68-76.
2008: Sigurdsson Snaevar; Nordmark Gunnel; Garnier Sophie; Grundberg Elin; Kwan Tony; Nilsson Olof; Eloranta Maija-Leena; Gunnarsson Iva; Svenungsson Elisabet; Sturfelt Gunnar; Bengtsson Anders A; Jönsen Andreas; Truedsson Lennart; Rantapää-Dahlqvist Solbritt; Eriksson Catharina; Alm Gunnar; Göring Harald H H; Pastinen Tomi; Syvänen Ann-Christine; Rönnblom Lars
A risk haplotype of STAT4 for systemic lupus erythematosus is over-expressed, correlates with anti-dsDNA and shows additive effects with two risk alleles of IRF5.
Human molecular genetics 2008;17(18):2868-76.
2008: Sigurdsson Snaevar; Göring Harald H H; Kristjansdottir Gudlaug; Milani Lili; Nordmark Gunnel; Sandling Johanna K; Eloranta Maija-Leena; Feng Di; Sangster-Guity Niquiche; Gunnarsson Iva; Svenungsson Elisabet; Sturfelt Gunnar; Jönsen Andreas; Truedsson Lennart; Barnes Betsy J; Alm Gunnar; Rönnblom Lars; Syvänen Ann-Christine
Comprehensive evaluation of the genetic variants of interferon regulatory factor 5 (IRF5) reveals a novel 5 bp length polymorphism as strong risk factor for systemic lupus erythematosus.
Human molecular genetics 2008;17(6):872-81.
2007: Eloranta Maija-Leena; Barbasso Helmers Sevim; Ulfgren Ann-Kristin; Rönnblom Lars; Alm Gunnar V; Lundberg Ingrid E
A possible mechanism for endogenous activation of the type I interferon system in myositis patients with anti-Jo-1 or anti-Ro 52/anti-Ro 60 autoantibodies.
Arthritis and rheumatism 2007;56(9):3112-24.
2007: Sigurdsson Snaevar; Padyukov Leonid; Kurreeman Fina A S; Liljedahl Ulrika; Wiman Ann-Christin; Alfredsson Lars; Toes René; Rönnelid Johan; Klareskog Lars; Huizinga Tom W J; Alm Gunnar; Syvänen Ann-Christine; Rönnblom Lars
Association of a haplotype in the promoter region of the interferon regulatory factor 5 gene with rheumatoid arthritis.
Arthritis and rheumatism 2007;56(7):2202-10.
2006: Lövgren Tanja; Eloranta Maija-Leena; Kastner Berthold; Wahren-Herlenius Marie; Alm Gunnar V; Rönnblom Lars
Induction of interferon-alpha by immune complexes or liposomes containing systemic lupus erythematosus autoantigen- and Sjögren's syndrome autoantigen-associated RNA.
Arthritis and rheumatism 2006;54(6):1917-27.
2006: Nordmark Gunnel; Alm Gunnar V; Rönnblom Lars
Mechanisms of Disease: primary Sjögren's syndrome and the type I interferon system.
Nature clinical practice. Rheumatology 2006;2(5):262-9.
2006: Rönnblom Lars; Eloranta Maija-Leena; Alm Gunnar V
The type I interferon system in systemic lupus erythematosus.
Arthritis and rheumatism 2006;54(2):408-20.
2005: Båve Ullvi; Nordmark Gunnel; Lövgren Tanja; Rönnelid Johan; Cajander Stefan; Eloranta Maija-Leena; Alm Gunnar V; Rönnblom Lars
Activation of the type I interferon system in primary Sjögren's syndrome: a possible etiopathogenic mechanism.
Arthritis and rheumatism 2005;52(4):1185-95.
2005: Sigurdsson Snaevar; Nordmark Gunnel; Göring Harald H H; Lindroos Katarina; Wiman Ann-Christin; Sturfelt Gunnar; Jönsen Andreas; Rantapää-Dahlqvist Solbritt; Möller Bozena; Kere Juha; Koskenmies Sari; Widén Elisabeth; Eloranta Maija-Leena; Julkunen Heikki; Kristjansdottir Helga; Steinsson Kristjan; Alm Gunnar; Rönnblom Lars; Syvänen Ann-Christine
Polymorphisms in the tyrosine kinase 2 and interferon regulatory factor 5 genes are associated with systemic lupus erythematosus.
American journal of human genetics 2005;76(3):528-37.
2005: Huang Y M; Adikari S; Båve U; Sanna A; Alm G
Multiple sclerosis: interferon-beta induces CD123(+)BDCA2- dendritic cells that produce IL-6 and IL-10 and have no enhanced type I interferon production.
Journal of neuroimmunology 2005;158(1-2):204-12.
2004: Domeika Kristina; Magnusson Mattias; Eloranta Maija-Leena; Fuxler Lisbeth; Alm Gunnar V; Fossum Caroline
Characteristics of oligodeoxyribonucleotides that induce interferon (IFN)-alpha in the pig and the phenotype of the IFN-alpha producing cells.
Veterinary immunology and immunopathology 2004;101(1-2):87-102.
2004: Lövgren Tanja; Eloranta Maija-Leena; Båve Ullvi; Alm Gunnar V; Rönnblom Lars
Induction of interferon-alpha production in plasmacytoid dendritic cells by immune complexes containing nucleic acid released by necrotic or late apoptotic cells and lupus IgG.
Arthritis and rheumatism 2004;50(6):1861-72.
2003: Rönnblom Lars; Eloranta Maija-Leena; Alm Gunnar V
Role of natural interferon-alpha producing cells (plasmacytoid dendritic cells) in autoimmunity.
Autoimmunity 2003;36(8):463-72.
2003: Blomberg Stina; Eloranta Maija-Leena; Magnusson Mattias; Alm Gunnar V; Rönnblom Lars
Expression of the markers BDCA-2 and BDCA-4 and production of interferon-alpha by plasmacytoid dendritic cells in systemic lupus erythematosus.
Arthritis and rheumatism 2003;48(9):2524-32.
2003: Båve Ullvi; Magnusson Mattias; Eloranta Maija-Leena; Perers Anders; Alm Gunnar V; Rönnblom Lars
Fc gamma RIIa is expressed on natural IFN-alpha-producing cells (plasmacytoid dendritic cells) and is required for the IFN-alpha production induced by apoptotic cells combined with lupus IgG.
Journal of immunology (Baltimore, Md. : 1950) 2003;171(6):3296-302.
2003: Johansson E; Domeika K; Berg M; Alm G V; Fossum C
Characterisation of porcine monocyte-derived dendritic cells according to their cytokine profile.
Veterinary immunology and immunopathology 2003;91(3-4):183-97.
2003: Jönsen A; Bengtsson A A; Nived O; Ryberg B; Truedsson L; Rönnblom L; Alm G V; Sturfelt G
The heterogeneity of neuropsychiatric systemic lupus erythematosus is reflected in lack of association with cerebrospinal fluid cytokine profiles.
Lupus 2003;12(11):846-50.
2003: Rönnblom Lars; Alm Gunnar V
Systemic lupus erythematosus and the type I interferon system.
Arthritis research & therapy 2003;5(2):68-75.
2002: Rönnblom Lars; Alm Gunnar V
The natural interferon-alpha producing cells in systemic lupus erythematosus.
Human immunology 2002;63(12):1181-93.
2002: Domeika K; Berg M; Eloranta M-L; Alm G V
Porcine interleukin-12 fusion protein and interleukin-18 in combination induce interferon-gamma production in porcine natural killer and T cells.
Veterinary immunology and immunopathology 2002;86(1-2):11-21.
2002: Lunney Joan K; Fossum Caroline; Alm Gunnar V; Steinbach Falko; Wattrang Eva
Veterinary immunology: opportunities and challenges.
Trends in immunology 2002;23(1):4-6.
2001: Magnusson M; Magnusson S; Vallin H; Rönnblom L; Alm G V
Importance of CpG dinucleotides in activation of natural IFN-alpha-producing cells by a lupus-related oligodeoxynucleotide.
Scandinavian journal of immunology 2001;54(6):543-50.
2001: Rönnblom L; Alm G V
A pivotal role for the natural interferon alpha-producing cells (plasmacytoid dendritic cells) in the pathogenesis of lupus.
The Journal of experimental medicine 2001;194(12):F59-63.
2001: Tölö H; Kauppinen H L; Alm G; Perers A; Lindeberg E; Wahlstedt-Fröberg V; Parkkinen J
Development of a highly purified multicomponent leukocyte IFN-alpha product.
Journal of interferon & cytokine research : the official journal of the International Society for Interferon and Cytokine Research 2001;21(11):913-20.
2001: Båve U; Vallin H; Alm G V; Rönnblom L
Activation of natural interferon-alpha producing cells by apoptotic U937 cells combined with lupus IgG and its regulation by cytokines.
Journal of autoimmunity 2001;17(1):71-80.
2001: Rönnblom L; Alm G V
An etiopathogenic role for the type I IFN system in SLE.
Trends in immunology 2001;22(8):427-31.
2001: Blomberg S; Eloranta M L; Cederblad B; Nordlin K; Alm G V; Rönnblom L
Presence of cutaneous interferon-alpha producing cells in patients with systemic lupus erythematosus.
Lupus 2001;10(7):484-90.
2000: Båve U; Alm G V; Rönnblom L
The combination of apoptotic U937 cells and lupus IgG is a potent IFN-alpha inducer.
Journal of immunology (Baltimore, Md. : 1950) 2000;165(6):3519-26.
2000: Bengtsson A A; Sturfelt G; Truedsson L; Blomberg J; Alm G; Vallin H; Rönnblom L
Activation of type I interferon system in systemic lupus erythematosus correlates with disease activity but not with antiretroviral antibodies.
Lupus 2000;9(9):664-71.
2000: Ljungdahl M; Fossum C; Alm G; Haglund U
Immune cell distribution in gut-associated lymphoid tissue and synthesis of IL-6 in experimental porcine peritonitis.
European surgical research. Europäische chirurgische Forschung. Recherches chirurgicales européennes 2000;32(6):323-30.
1999: Vallin H; Perers A; Alm G V; Rönnblom L
Anti-double-stranded DNA antibodies and immunostimulatory plasmid DNA in combination mimic the endogenous IFN-alpha inducer in systemic lupus erythematosus.
Journal of immunology (Baltimore, Md. : 1950) 1999;163(11):6306-13.
1999: Eloranta M L; Alm G V
Splenic marginal metallophilic macrophages and marginal zone macrophages are the major interferon-alpha/beta producers in mice upon intravenous challenge with herpes simplex virus.
Scandinavian journal of immunology 1999;49(4):391-4.
1999: Vallin H; Blomberg S; Alm G V; Cederblad B; Rönnblom L
Patients with systemic lupus erythematosus (SLE) have a circulating inducer of interferon-alpha (IFN-alpha) production acting on leucocytes resembling immature dendritic cells.
Clinical and experimental immunology 1999;115(1):196-202.
1998: Cederblad B; Blomberg S; Vallin H; Perers A; Alm G V; Rönnblom L
Patients with systemic lupus erythematosus have reduced numbers of circulating natural interferon-alpha- producing cells.
Journal of autoimmunity 1998;11(5):465-70.
1998: Erlandsson L; Blumenthal R; Eloranta M L; Engel H; Alm G; Weiss S; Leanderson T
Interferon-beta is required for interferon-alpha production in mouse fibroblasts.
Current biology : CB 1998;8(4):223-6.
1997: Eloranta M L; Sandberg K; Ricciardi-Castagnoli P; Lindahl M; Alm G V
Production of interferon-alpha/beta by murine dendritic cell lines stimulated by virus and bacteria.
Scandinavian journal of immunology 1997;46(3):235-41.
1997: Pauksen K; Sjölin J; Linde A; Alm G; Andersson B; Lönnerholm G; Ljungman P
Th1 and Th2 cytokine responses after measles antigen stimulation in vitro in bone marrow transplant patients: response to measles vaccination.
Bone marrow transplantation 1997;20(4):317-23.
1997: Rönnblom L E; Perers A; Vallin H S; Eriksson I; Osterlind A; Cederblad B; Alm G
Detection of serum interferon-alpha by dissociation-enhanced lanthanide fluoroimmunoassay. Studies of patients with acute viral and bacterial infections.
APMIS : acta pathologica, microbiologica, et immunologica Scandinavica 1997;105(7):531-6.
1996: Riffault S; Eloranta M L; Carrat C; Sandberg K; Charley B; Alm G
Herpes simplex virus induces appearance of interferon-alpha/beta-producing cells and partially interferon-alpha/beta-dependent accumulation of leukocytes in murine regional lymph nodes.
Journal of interferon & cytokine research : the official journal of the International Society for Interferon and Cytokine Research 1996;16(12):1007-14.
1996: Svensson H; Johannisson A; Nikkilä T; Alm G V; Cederblad B
The cell surface phenotype of human natural interferon-alpha producing cells as determined by flow cytometry.
Scandinavian journal of immunology 1996;44(2):164-72.
1996: Eloranta M L; Sandberg K; Alm G V
The interferon-alpha/beta responses of mice to herpes simplex virus studied at the blood and tissue level in vitro and in vivo.
Scandinavian journal of immunology 1996;43(4):356-60.
1996: Svensson H; Cederblad B; Lindahl M; Alm G
Stimulation of natural interferon-alpha/beta-producing cells by Staphylococcus aureus.
Journal of interferon & cytokine research : the official journal of the International Society for Interferon and Cytokine Research 1996;16(1):7-16.
1995: Artursson K; Lindersson M; Varela N; Scheynius A; Alm G V
Interferon-alpha production and tissue localization of interferon-alpha/beta producing cells after intradermal administration of Aujeszky's disease virus-infected cells in pigs.
Scandinavian journal of immunology 1995;41(2):121-9.
1993: Cederblad B; Sandberg K; Alm G V
The leukocyte function-associated antigen-1 (LFA-1) is involved in the interferon-alpha response induced by herpes simplex virus in blood leukocytes.
Journal of interferon research 1993;13(3):203-8.
1993: Wallgren P; Artursson K; Fossum C; Alm G V
Incidence of infections in pigs bred for slaughter revealed by elevated serum levels of interferon and development of antibodies to Mycoplasma hyopneumoniae and Actinobacillus pleuropneumoniae.
Zentralblatt für Veterinärmedizin. Reihe B. Journal of veterinary medicine. Series B 1993;40(1):1-12.
1992: Rönnblom L E; Janson E T; Perers A; Oberg K E; Alm G V
Characterization of anti-interferon-alpha antibodies appearing during recombinant interferon-alpha 2a treatment.
Clinical and experimental immunology 1992;89(3):330-5.
1992: Janson E T; Rönnblom L; Ahlström H; Grandér D; Alm G; Einhorn S; Oberg K
Treatment with alpha-interferon versus alpha-interferon in combination with streptozocin and doxorubicin in patients with malignant carcinoid tumors: a randomized trial.
Annals of oncology : official journal of the European Society for Medical Oncology / ESMO 1992;3(8):635-8.
1992: Artursson K; Gobl A; Lindersson M; Johansson M; Alm G
Molecular cloning of a gene encoding porcine interferon-beta.
Journal of interferon research 1992;12(3):153-60.
1992: Gobl A E; Cederblad B; Sandberg K; Alm G V
Interferon-alpha but not -beta genes require de novo protein synthesis for efficient expression in human monocytes.
Scandinavian journal of immunology 1992;35(2):177-85.
1992: Gobl A E; Alm G V
Interleukin-4 down-regulates Sendai virus-induced production of interferon-alpha and -beta in human peripheral blood monocytes in vitro.
Scandinavian journal of immunology 1992;35(2):167-75.
1992: Diaz de Arce H; Artursson K; L'Haridon R; Perers A; La Bonnardiere C; Alm G V
A sensitive immunoassay for porcine interferon-alpha.
Veterinary immunology and immunopathology 1992;30(4):319-27.
1991: Cederblad B; Gobl A E; Alm G V
The induction of interferon-alpha and interferon-beta mRNA in human natural interferon-producing blood leukocytes requires de novo protein synthesis.
Journal of interferon research 1991;11(6):371-7.
1991: Sandberg K; Eloranta M L; Johannisson A; Alm G V
Flow cytometric analysis of natural interferon-alpha producing cells.
Scandinavian journal of immunology 1991;34(5):565-76.
1991: Cederblad B; Alm G V
Interferons and the colony-stimulating factors IL-3 and GM-CSF enhance the IFN-alpha response in human blood leucocytes induced by herpes simplex virus.
Scandinavian journal of immunology 1991;34(5):549-55.
1991: Sandberg K; Eloranta M L; Gobl A E; Alm G V
Phorbol ester-mediated inhibition of IFN-alpha/beta gene transcription in blood mononuclear leukocytes.
Journal of immunology (Baltimore, Md. : 1950) 1991;147(9):3116-21.
1991: Rönnblom L E; Alm G V; Oberg K E
Autoimmunity after alpha-interferon therapy for malignant carcinoid tumors.
Annals of internal medicine 1991;115(3):178-83.
1991: Rönnblom L E; Alm G V; Oberg K
Autoimmune phenomena in patients with malignant carcinoid tumors during interferon-alpha treatment.
Acta oncologica (Stockholm, Sweden) 1991;30(4):537-40.
1990: Sandberg K; Matsson P; Alm G V
A distinct population of nonphagocytic and low level CD4+ null lymphocytes produce IFN-alpha after stimulation by herpes simplex virus-infected cells.
Journal of immunology (Baltimore, Md. : 1950) 1990;145(3):1015-20.
1990: Prümmer O; Cederblad B; Alm G; Drees N; Porzsolt F
Filter spot-ELISA for the enumeration of interferon-alpha antibody-secreting cells.
Journal of immunological methods 1990;130(2):187-93.
1990: Karlsson-Parra A; Burman P; Hagberg H; Oberg K; Alm G; Klareskog L; Karlsson F A
Autoantibodies to epithelial cells in patients on long-term therapy with leucocyte-derived interferon-alpha (IFN-alpha).
Clinical and experimental immunology 1990;81(1):72-5.
1990: Rönnblom L E; Alm G V; Oberg K E
Possible induction of systemic lupus erythematosus by interferon-alpha treatment in a patient with a malignant carcinoid tumour.
Journal of internal medicine 1990;227(3):207-10.
1990: Cederblad B; Alm G V
Infrequent but efficient interferon-alpha-producing human mononuclear leukocytes induced by herpes simplex virus in vitro studied by immuno-plaque and limiting dilution assays.
Journal of interferon research 1990;10(1):65-73.
1990: Cederblad B; Riesenfeld T; Alm G V
Deficient herpes simplex virus-induced interferon-alpha production by blood leukocytes of preterm and term newborn infants.
Pediatric research 1990;27(1):7-10.
1989: Artursson K; Wallgren P; Alm G V
Appearance of interferon-alpha in serum and signs of reduced immune function in pigs after transport and installation in a fattening farm.
Veterinary immunology and immunopathology 1989;23(3-4):345-53.
1989: Sandberg K; Gobl A E; Funa K; Alm G V
Characterization of the blood mononuclear leucocytes producing alpha interferon after stimulation with herpes simplex virus in vitro, by means of combined immunohistochemical staining and in situ RNA-RNA hybridization.
Scandinavian journal of immunology 1989;29(6):651-8.
1988: Gobl A E; Funa K; Alm G V
Different induction patterns of mRNA for IFN-alpha and -beta in human mononuclear leukocytes after in vitro stimulation with herpes simplex virus-infected fibroblasts and Sendai virus.
Journal of immunology (Baltimore, Md. : 1950) 1988;140(10):3605-9.
1988: Rönnblom L; Cederblad B; Sandberg K; Alm G V
Determination of herpes simplex virus-induced alpha interferon-secreting human blood leucocytes by a filter immuno-plaque assay.
Scandinavian journal of immunology 1988;27(2):165-70.
1987: Alm G V
Lymphokines in the regulation of immune responses.
Veterinary immunology and immunopathology 1987;17(1-4):173-82.
1985: Funa K; Ramstedt U; Rönnblom L; Alm G V
Human peripheral blood null lymphocytes stimulated by Staphylococcus aureus Cowan I produce atypical acid-labile interferon in vitro.
Scandinavian journal of immunology 1985;21(1):55-62.
1984: Claesson K; Rönnblom L; Alm G; Tufveson G
Antiviral activity appearing in serum of renal transplant recipients. Its possible relation to immunological rejection.
Transplantation 1984;38(1):32-4.
1983: Funa K; Alm G V; Rönnblom L; Oberg K
Evaluation of the natural killer cell-interferon system in patients with mid-gut carcinoid tumours treated with leucocyte interferon.
Clinical and experimental immunology 1983;53(3):716-24.
1983: Rönnblom L; Ramstedt U; Alm G V
Properties of human natural interferon-producing cells stimulated by tumor cell lines.
European journal of immunology 1983;13(6):471-6.
1983: Rönnblom L; Forsgren A; Alm G V
Characterization of interferons induced by bacteria and interferon-producing leukocytes in human peripheral blood.
Infection and immunity 1983;40(1):126-32.
1983: Rönnblom L; Ojo-Amaize E A; Franzén L; Wigzell H; Alm G V
Plasmodium falciparum parasites induce interferon production in human peripheral blood 'null' cells in vitro.
Parasite immunology 1983;5(2):165-72.
1982: Rönnblom L; Funa K; Ersson B; Alm G V
Lectins as inducers of interferon-gamma production in human lymphocytes: lentil lectin is highly efficient.
Scandinavian journal of immunology 1982;16(4):327-31.
1982: Rönnblom L; Alm G V
Limiting dilution analysis of human peripheral blood mononuclear leukocytes that react to human amnion cells and protect these against viral challenge.
European journal of immunology 1982;12(5):437-41.
1981: Ojo-Amaize E A; Salimonu L S; Williams A I; Akinwolere O A; Shabo R; Alm G V; Wigzell H
Positive correlation between degree of parasitemia, interferon titers, and natural killer cell activity in Plasmodium falciparum-infected children.
Journal of immunology (Baltimore, Md. : 1950) 1981;127(6):2296-300.

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