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David Cribbs

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Nicole C Berchtold; Paul D. Coleman; David H Cribbs; Daniel L Gillen; Joseph Rogers; Carl W Cotman
Synaptic genes are extensively downregulated across multiple brain regions in normal human aging and Alzheimer's disease.
Rodrigo Medeiros; Giselle F Passos; David Baglietto-Vargas; David Cheng; David H Cribbs; Masashi Kitazawa; Frank M LaFerla
Aspirin-triggered lipoxin a4 stimulates alternative activation of microglia and reduces Alzheimer disease-like pathology in mice.
Giselle F Passos; Vitaly Vasilevko; David Cheng; Frank M LaFerla; Rodrigo Medeiros; David H Cribbs
The Bradykinin B1 Receptor Regulates Aβ Deposition and Neuroinflammation in Tg-SwDI Mice.

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2013: Nicole C Berchtold; Paul D. Coleman; David H Cribbs; Daniel L Gillen; Joseph Rogers; Carl W Cotman
Synaptic genes are extensively downregulated across multiple brain regions in normal human aging and Alzheimer's disease.
Neurobiology of aging 2013;34(6):1653-61.
2013: Rodrigo Medeiros; Giselle F Passos; David Baglietto-Vargas; David Cheng; David H Cribbs; Masashi Kitazawa; Frank M LaFerla
Aspirin-triggered lipoxin a4 stimulates alternative activation of microglia and reduces Alzheimer disease-like pathology in mice.
The American journal of pathology 2013;182(5):1780-9.
2013: Giselle F Passos; Vitaly Vasilevko; David Cheng; Frank M LaFerla; Rodrigo Medeiros; David H Cribbs
The Bradykinin B1 Receptor Regulates Aβ Deposition and Neuroinflammation in Tg-SwDI Mice.
The American journal of pathology 2013;182(5):1740-9.
2013: Hayk Davtyan; Dorte Kornerup Ditlevsen; Anahit Ghochikyan; Armine Hovakimyan; Anatoly Kiyatkin; Anna Kirstine Larsen; Peter Juul Madsen; Annette M Marleau; Nina Movsesyan; Lars Ostergaard Pedersen; Irina Petrushina; Anna Poghosyan; Suhail Rasool; Karen Malene Wegener; David H Cribbs; Arpine Davtyan; Michael G Agadjanyan
Immunogenicity, efficacy, safety, and mechanism of action of epitope vaccine (Lu AF20513) for Alzheimer's disease: prelude to a clinical trial.
The Journal of neuroscience : the official journal of the Society for Neuroscience 2013;33(11):4923-34.
2012: Liqi Tong; David H Cribbs; Enikö A Kramár; Gary Lynch; G Aleph Prieto; Erica D Smith; Carl W Cotman
Brain-derived neurotrophic factor-dependent synaptic plasticity is suppressed by interleukin-1β via p38 mitogen-activated protein kinase.
The Journal of neuroscience : the official journal of the Society for Neuroscience 2012;32(49):17714-24.
2012: Kwang-Mook Jung; Vitaly Vasilevko; Sevil Yasar; Giuseppe Astarita; Carl W Cotman; David H Cribbs; Elizabeth Head; Daniele Piomelli
An amyloid β42-dependent deficit in anandamide mobilization is associated with cognitive dysfunction in Alzheimer's disease.
Neurobiology of aging 2012;33(8):1522-32.
2012: Tommy Saing; David H Cribbs; Malcolm Dick; Ronald C Kim; Peter T Nelson; Elizabeth Head
Frontal cortex neuropathology in dementia pugilistica.
Journal of neurotrauma 2012;29(6):1054-70.
2012: Luis Fernando Hernandez-Zimbron; Carlos Kubli-Garfias; Jose Luna-Muñoz; Karen Manoutcharian; Raul Mena; Ricardo Vazquez-Ramirez; David H Cribbs; Goar Gevorkian
Amyloid-β peptide binds to cytochrome C oxidase subunit 1.
PloS one 2012;7(8):e42344.
2012: David H Cribbs; Victoria M Perreau; Joseph Rogers; Andrea J Tenner; Nicole C Berchtold; Paul D Coleman; Carl W Cotman
Extensive innate immune gene activation accompanies brain aging, increasing vulnerability to cognitive decline and neurodegeneration: a microarray study.
Journal of neuroinflammation 2012;9():179.
2012: Hayk Davtyan; Barry Ellefsen; Claire F Evans; Anahit Ghochikyan; Drew Hannaman; Nina Movsesyan; Irina Petrushina; David H Cribbs; Michael G Agadjanyan
Delivery of a DNA vaccine for Alzheimer's disease by electroporation versus gene gun generates potent and similar immune responses.
Neuro-degenerative diseases 2012;10(1-4):261-4.
2011: Masashi Kitazawa; Paul D Wes; David Cheng; Vitaly Vasilevko; Michelle R Tsukamoto; David H Cribbs; Maya A Koike; Frank M LaFerla
Blocking IL-1 signaling rescues cognition, attenuates tau pathology, and restores neuronal β-catenin pathway function in an Alzheimer's disease model.
Journal of immunology (Baltimore, Md. : 1950) 2011;187(12):6539-49.
2011: Mark Fisher; Giselle F Passos; Daniel Quiring; Vitaly Vasilevko; Christopher Ventura; David H Cribbs
Therapeutic modulation of cerebral microhemorrhage in a mouse model of cerebral amyloid angiopathy.
Stroke; a journal of cerebral circulation 2011;42(11):3300-3.
2011: Rodrigo Medeiros; David Baglietto-Vargas; Antonella Caccamo; David H Cribbs; Tatiana Estrada-Hernandez; Avraham Fisher; Masashi Kitazawa; Frank M LaFerla
Loss of muscarinic M1 receptor exacerbates Alzheimer's disease-like pathology and cognitive decline.
The American journal of pathology 2011;179(2):980-91.
2011: Giuseppe Astarita; Carl W Cotman; David H Cribbs; Nicholas V Dipatrizio; Elizabeth Head; Kwang-Mook Jung; Sarah K Martin; Vitaly Vasilevko; Daniele Piomelli
Elevated stearoyl-CoA desaturase in brains of patients with Alzheimer's disease.
PloS one 2011;6(10):e24777.
2011: Mkrtichyan Mikayel; Nina Movsesyan; Edward L Nelson; David H Cribbs; Hayk Davtyan; Anahit Ghochikyan; Amanda K Laust; Victor Lobanenkov; Dmitri Loukinov; Michael G Agadjanyan
Cancer-testis antigen, BORIS based vaccine delivered by dendritic cells is extremely effective against a very aggressive and highly metastatic mouse mammary carcinoma.
Cellular immunology 2011;270(2):188-97.
2010: Roxanna Perez-Garmendia; Vanessa Ibarra-Bracamontes; Vitaly Vasilevko; Jose Luna-Muñoz; Raul Mena; Tzipe Govezensky; Gonzalo Acero; Karen Manoutcharian; David H Cribbs; Goar Gevorkian
Anti-11[E]-pyroglutamate-modified amyloid β antibodies cross-react with other pathological Aβ species: relevance for immunotherapy.
Journal of neuroimmunology 2010;229(1-2):248-55.
2010: Remy Robert; Marie-Paule Lefranc; Anahit Ghochikyan; Michael G Agadjanyan; David H Cribbs; William E Van Nostrand; Kim L Wark; Olan Dolezal
Restricted V gene usage and VH/VL pairing of mouse humoral response against the N-terminal immunodominant epitope of the amyloid β peptide.
Molecular immunology 2010;48(1-3):59-72.
2010: Nina Movsesyan; Hayk Davtyan; Mikayel Mkrtichyan; Irina Petrushina; Tigran Tiraturyan; Ted Ross; Michael G Agadjanyan; Anahit Ghochikyan; David H Cribbs
Low concentrations of anti-Aβ antibodies generated in Tg2576 mice by DNA epitope vaccine fused with 3C3d molecular adjuvant do not affect AD pathology.
Human gene therapy 2010;21(11):1569-76.
2010: Vitaly Vasilevko; Giselle F Passos; Daniel Quiring; Elizabeth Head; Richard C Kim; Mark Fisher; David H Cribbs
Aging and cerebrovascular dysfunction: contribution of hypertension, cerebral amyloid angiopathy, and immunotherapy.
Annals of the New York Academy of Sciences 2010;1207():58-70.
2010: Vitaly Vasilevko; Viorela Pop; Hyun Jin Kim; Tommy Saing; Charles C Glabe; Saskia Milton; Edward G Barrett; Carl W Cotman; David H Cribbs; Elizabeth Head
Linear and conformation specific antibodies in aged beagles after prolonged vaccination with aggregated Abeta.
Neurobiology of disease 2010;39(3):301-10.
2010: M Medecigo; Karen Manoutcharian; Vitaly Vasilevko; Tzipe Govezensky; Maria Elena Munguia; Baltazar Becerril; Agustín Luz-Madrigal; L Vaca; David H Cribbs; Goar Gevorkian
Novel amyloid-beta specific scFv and VH antibody fragments from human and mouse phage display antibody libraries.
Journal of neuroimmunology 2010;223(1-2):104-14.
2010: David H Cribbs
Abeta DNA vaccination for Alzheimer's disease: focus on disease prevention.
CNS & neurological disorders drug targets 2010;9(2):207-16.
2010: H Davtyan; Mkrtichyan Mikayel; N Movsesyan; Irina Petrushina; G Mamikonyan; David H Cribbs; Michael G Agadjanyan; Anahit Ghochikyan
DNA prime-protein boost increased the titer, avidity and persistence of anti-Abeta antibodies in wild-type mice.
Gene therapy 2010;17(2):261-71.
2010: Anna Parachikova; Vitaly Vasilevko; David H Cribbs; Frank M LaFerla; Kim N Green
Reductions in amyloid-beta-derived neuroinflammation, with minocycline, restore cognition but do not significantly affect tau hyperphosphorylation.
Journal of Alzheimer's disease : JAD 2010;21(2):527-42.
2009: Floyd Sarsoza; Tommy Saing; Rakez Kayed; Robert Dahlin; Malcolm Dick; Camille Broadwater-Hollifield; Scott Mobley; Ira T Lott; Eric Doran; Daniel Gillen; Clifford Anderson-Bergman; David H Cribbs; Charles G Glabe; Elizabeth Head
A fibril-specific, conformation-dependent antibody recognizes a subset of Abeta plaques in Alzheimer disease, Down syndrome and Tg2576 transgenic mouse brain.
Acta neuropathologica 2009;118(4):505-17.
2009: Gonzalo Acero; Karen Manoutcharian; Vitaly Vasilevko; Maria Elena Munguia; Tzipe Govezensky; G Coronas; Agustín Luz-Madrigal; David H Cribbs; Goar Gevorkian
Immunodominant epitope and properties of pyroglutamate-modified Abeta-specific antibodies produced in rabbits.
Journal of neuroimmunology 2009;213(1-2):39-46.
2009: Masashi Kitazawa; Vitaly Vasilevko; David H Cribbs; Frank M LaFerla
Immunization with amyloid-beta attenuates inclusion body myositis-like myopathology and motor impairment in a transgenic mouse model.
The Journal of neuroscience : the official journal of the Society for Neuroscience 2009;29(19):6132-41.
2009: David H Cribbs; Michael G Agadjanyan
Active and passive Abeta-immunotherapy: preclinical and clinical studies and future directions: part II.
CNS & neurological disorders drug targets 2009;8(2):82-7.
2009: Michael G Agadjanyan; David H Cribbs
Active and passive Abeta-immunotherapy: preclinical and clinical studies and future directions: part I.
CNS & neurological disorders drug targets 2009;8(1):1-6.
2008: Nina Movsesyan; Mkrtichyan Mikayel; Irina Petrushina; Ted M Ross; David H Cribbs; Michael G Agadjanyan; Anahit Ghochikyan
DNA epitope vaccine containing complement component C3d enhances anti-amyloid-beta antibody production and polarizes the immune response towards a Th2 phenotype.
Journal of neuroimmunology 2008;205(1-2):57-63.
2008: Salvatore Oddo; Antonella Caccamo; Bert Tseng; David Cheng; Vitaly Vasilevko; David H Cribbs; Frank M LaFerla
Blocking Abeta42 accumulation delays the onset and progression of tau pathology via the C terminus of heat shock protein70-interacting protein: a mechanistic link between Abeta and tau pathology.
The Journal of neuroscience : the official journal of the Society for Neuroscience 2008;28(47):12163-75.
2008: Nicole C Berchtold; David H Cribbs; Paul D. Coleman; Joseph Rogers; Elizabeth Head; Ronald Kim; Thomas Beach; Carol Miller; Juan C Troncoso; John Q Trojanowski; H Ronald Zielke; Carl W Cotman
Gene expression changes in the course of normal brain aging are sexually dimorphic.
Proceedings of the National Academy of Sciences of the United States of America 2008;105(40):15605-10.
2008: Goar Gevorkian; Alfonso Gonzalez-Noriega; Gonzalo Acero; Jorge Ordoñez; Colette Michalak; Maria Elena Munguia; Tzipe Govezensky; David H Cribbs; Karen Manoutcharian
Amyloid-beta peptide binds to microtubule-associated protein 1B (MAP1B).
Neurochemistry international 2008;52(6):1030-6.
2008: Elizabeth Head; Viorela Pop; Vitaly Vasilevko; MaryAnn Hill; Tommy Saing; Floyd Sarsoza; Michaela Nistor; Lori-Ann Christie; Saskia Milton; Charles G Glabe; Edward Barrett; David H Cribbs
A two-year study with fibrillar beta-amyloid (Abeta) immunization in aged canines: effects on cognitive function and brain Abeta.
The Journal of neuroscience : the official journal of the Society for Neuroscience 2008;28(14):3555-66.
2008: R S Solórzano-Vargas; Vitaly Vasilevko; Gonzalo Acero; Kenneth Ugen; R Martinez; Tzipe Govezensky; R Vazquez-Ramirez; C Kubli-Garfias; David H Cribbs; Karen Manoutcharian; Goar Gevorkian
Epitope mapping and neuroprotective properties of a human single chain FV antibody that binds an internal epitope of amyloid-beta 1-42.
Molecular immunology 2008;45(4):881-6.
2008: Irina Petrushina; Anahit Ghochikyan; Mikayel Mkrtichyan; Grigor Mamikonyan; Nina Movsesyan; Rodmehr Ajdari; Vitaly Vasilevko; Adrine Karapetyan; Andrew Lees; Michael G Agadjanyan; David H Cribbs
Mannan-Abeta28 conjugate prevents Abeta-plaque deposition, but increases microhemorrhages in the brains of vaccinated Tg2576 (APPsw) mice.
Journal of neuroinflammation 2008;5():42.
2008: Nina Movsesyan; Anahit Ghochikyan; Mkrtichyan Mikayel; Irina Petrushina; Hayk Davtyan; Purevdorj B Olkhanud; Elizabeth Head; Arya Biragyn; David H Cribbs; Michael G Agadjanyan
Reducing AD-like pathology in 3xTg-AD mouse model by DNA epitope vaccine - a novel immunotherapeutic strategy.
PloS one 2008;3(5):e2124.
2008: Kathryn E Nichol; Wayne W Poon; Anna I Parachikova; David H Cribbs; Charles G Glabe; Carl W Cotman
Exercise alters the immune profile in Tg2576 Alzheimer mice toward a response coincident with improved cognitive performance and decreased amyloid.
Journal of neuroinflammation 2008;5():13.
2008: Mkrtichyan Mikayel; Anahit Ghochikyan; Dmitri Loukinov; H Davtyan; Thomas E Ichim; David H Cribbs; Victor Lobanenkov; Michael G Agadjanyan
DNA, but not protein vaccine based on mutated BORIS antigen significantly inhibits tumor growth and prolongs the survival of mice.
Gene therapy 2008;15(1):61-4.
2008: Mkrtichyan Mikayel; Anahit Ghochikyan; Nina Movsesyan; Adrine Karapetyan; Gayane Begoyan; Jianmei Yu; Gregory M Glenn; Ted M Ross; Michael G Agadjanyan; David H Cribbs
Immunostimulant adjuvant patch enhances humoral and cellular immune responses to DNA immunization.
DNA and cell biology 2008;27(1):19-24.
2007: Vitaly Vasilevko; Feng Xu; Mary Lou Previti; William E Van Nostrand; David H Cribbs
Experimental investigation of antibody-mediated clearance mechanisms of amyloid-beta in CNS of Tg-SwDI transgenic mice.
The Journal of neuroscience : the official journal of the Society for Neuroscience 2007;27(49):13376-83.
2007: Anna Parachikova; Michael G Agadjanyan; David H Cribbs; Mathew Blurton-Jones; V Perreau; Joseph Rogers; Thomas Beach; Carl W Cotman
Inflammatory changes parallel the early stages of Alzheimer disease.
Neurobiology of aging 2007;28(12):1821-33.
2007: Irina Petrushina; Anahit Ghochikyan; Mikayel Mktrichyan; Gregory Mamikonyan; Nina Movsesyan; Hayk Davtyan; Archita Patel; Elizabeth Head; David H Cribbs; Michael G Agadjanyan
Alzheimer's disease peptide epitope vaccine reduces insoluble but not soluble/oligomeric Abeta species in amyloid precursor protein transgenic mice.
The Journal of neuroscience : the official journal of the Society for Neuroscience 2007;27(46):12721-31.
2007: Gregory Mamikonyan; Mihaela Necula; Mkrtichyan Mikayel; Anahit Ghochikyan; Irina Petrushina; Nina Movsesyan; Erene Mina; Anatoly Kiyatkin; Charles G Glabe; David H Cribbs; Michael G Agadjanyan
Anti-A beta 1-11 antibody binds to different beta-amyloid species, inhibits fibril formation, and disaggregates preformed fibrils but not the most toxic oligomers.
The Journal of biological chemistry 2007;282(31):22376-86.
2007: Milan Fiala; David H Cribbs; Mark Rosenthal; George Bernard
Phagocytosis of amyloid-beta and inflammation: two faces of innate immunity in Alzheimer's disease.
Journal of Alzheimer's disease : JAD 2007;11(4):457-63.
2007: Seog Woo Rhee; Anne Taylor; David H Cribbs; Carl W Cotman; Noo Li Jeon
External force-assisted cell positioning inside microfluidic devices.
Biomedical microdevices 2007;9(1):15-23.
2007: Joseph Harris; Hyuna Lee; Behrad Vahidi; Cristina Tu; David H Cribbs; Carl W Cotman; Noo Li Jeon
Non-plasma bonding of PDMS for inexpensive fabrication of microfluidic devices.
Journal of visualized experiments : JoVE 2007;(9):410.
2007: Joseph Harris; Hyuna Lee; Behrad Vahidi; Christina Tu; David H Cribbs; Noo Li Jeon; Carl W Cotman
Fabrication of a microfluidic device for the compartmentalization of neuron soma and axons.
Journal of visualized experiments : JoVE 2007;(7):261.
2007: Joseph Harris; Hyuna Lee; Christina Tu Tu; David H Cribbs; Carl W Cotman; Noo Li Jeon
Preparing e18 cortical rat neurons for compartmentalization in a microfluidic device.
Journal of visualized experiments : JoVE 2007;(8):305.
2007: Anahit Ghochikyan; Mkrtichyan Mikayel; Dmitri Loukinov; Gregory Mamikonyan; Svetlana D Pack; Nina Movsesyan; Thomas E Ichim; David H Cribbs; Victor Lobanenkov; Michael G Agadjanyan
Elicitation of T cell responses to histologically unrelated tumors by immunization with the novel cancer-testis antigen, brother of the regulator of imprinted sites.
Journal of immunology (Baltimore, Md. : 1950) 2007;178(1):566-73.
2006: Salvatore Oddo; Vitaly Vasilevko; Antonella Caccamo; Masashi Kitazawa; David H Cribbs; Frank M LaFerla
Reduction of soluble Abeta and tau, but not soluble Abeta alone, ameliorates cognitive decline in transgenic mice with plaques and tangles.
The Journal of biological chemistry 2006;281(51):39413-23.
2006: Anahit Ghochikyan; Irina Petrushina; Andrew Lees; Vitaly Vasilevko; Nina Movsesyan; Adrine Karapetyan; Michael G Agadjanyan; David H Cribbs
Abeta-immunotherapy for Alzheimer's disease using mannan-amyloid-Beta peptide immunoconjugates.
DNA and cell biology 2006;25(10):571-80.
2006: Elizabeth Head; Arnold Starr; Ronald C Kim; Anna Parachikova; Genaro E Lopez; Malcolm Dick; David H Cribbs
Relapsing polychondritis with features of dementia with Lewy bodies.
Acta neuropathologica 2006;112(2):217-25.
2006: Dmitri Loukinov; Anahit Ghochikyan; Mkrtichyan Mikayel; Thomas E Ichim; Victor Lobanenkov; David H Cribbs; Michael G Agadjanyan
Antitumor efficacy of DNA vaccination to the epigenetically acting tumor promoting transcription factor BORIS and CD80 molecular adjuvant.
Journal of cellular biochemistry 2006;98(5):1037-43.
2006: Vitaly Vasilevko; David H Cribbs
Novel approaches for immunotherapeutic intervention in Alzheimer's disease.
Neurochemistry international 2006;49(2):113-26.
2006: Elizabeth Head; Edward G Barrett; Michael Murphy; Pritam Das; Mihaela Nistor; Floyd Sarsoza; Charles C Glabe; Rakez Kayed; Saskia Milton; Vitaly Vasilevko; Norton W Milgram; Michael G Agadjanyan; David H Cribbs; Carl W Cotman
Immunization with fibrillar Abeta(1-42) in young and aged canines: Antibody generation and characteristics, and effects on CSF and brain Abeta.
Vaccine 2006;24(15):2824-34.
2006: Anahit Ghochikyan; Mkrtichyan Mikayel; Irina Petrushina; Nina Movsesyan; Adrine Karapetyan; David H Cribbs; Michael G Agadjanyan
Prototype Alzheimer's disease epitope vaccine induced strong Th2-type anti-Abeta antibody response with Alum to Quil A adjuvant switch.
Vaccine 2006;24(13):2275-82.
2005: Anne Taylor; Mathew Blurton-Jones; Seog Woo Rhee; David H Cribbs; Carl W Cotman; Noo Li Jeon
A microfluidic culture platform for CNS axonal injury, regeneration and transport.
Nature methods 2005;2(8):599-605.
2005: Michael G Agadjanyan; Anahit Ghochikyan; Irina Petrushina; Vitaly Vasilevko; Nina Movsesyan; Mkrtichyan Mikayel; Tommy Saing; David H Cribbs
Prototype Alzheimer's disease vaccine using the immunodominant B cell epitope from beta-amyloid and promiscuous T cell epitope pan HLA DR-binding peptide.
Journal of immunology (Baltimore, Md. : 1950) 2005;174(3):1580-6.
2005: Jun Zhou; Maria I Fonseca; Rakez Kayed; Irma Hernandez; Scott D Webster; Ozkan Yazan; David H Cribbs; Charles G Glabe; Andrea J Tenner
Novel Abeta peptide immunogens modulate plaque pathology and inflammation in a murine model of Alzheimer's disease.
Journal of neuroinflammation 2005;2():28.
2005: Seog Woo Rhee; Anne Taylor; Christina H Tu; David H Cribbs; Carl W Cotman; Noo Li Jeon
Patterned cell culture inside microfluidic devices.
Lab on a chip 2005;5(1):102-7.
2004: Goar Gevorkian; Irina Petrushina; Karen Manoutcharian; Anahit Ghochikyan; Gonzalo Acero; Vitaly Vasilevko; David H Cribbs; Michael G Agadjanyan
Mimotopes of conformational epitopes in fibrillar beta-amyloid.
Journal of neuroimmunology 2004;156(1-2):10-20.
2004: Salvatore Oddo; Lauren M Billings; J Patrick Kesslak; David H Cribbs; Frank M LaFerla
Abeta immunotherapy leads to clearance of early, but not late, hyperphosphorylated tau aggregates via the proteasome.
Neuron 2004;43(3):321-32.
2004: David H Cribbs; Wayne W Poon; Robert A Rissman; Mathew Blurton-Jones
Caspase-mediated degeneration in Alzheimer's disease.
The American journal of pathology 2004;165(2):353-5.
2003: Anahit Ghochikyan; Vitaly Vasilevko; Irina Petrushina; Nina Movsesyan; Davit Babikyan; Wenqiang Tian; Nadya Sadzikava; Ted M Ross; Elizabeth Head; David H Cribbs; Michael G Agadjanyan
Generation and characterization of the humoral immune response to DNA immunization with a chimeric beta-amyloid-interleukin-4 minigene.
European journal of immunology 2003;33(12):3232-41.
2003: Joseph H Su; Aileen J Anderson; David H Cribbs; Christina Tu; Liqi Tong; Patrick Kesslack; Carl W Cotman
Fas and Fas ligand are associated with neuritic degeneration in the AD brain and participate in beta-amyloid-induced neuronal death.
Neurobiology of disease 2003;12(3):182-93.
2003: David H Cribbs; Anahit Ghochikyan; Vitaly Vasilevko; Mike Tran; Irina Petrushina; Nadya Sadzikava; Davit Babikyan; Patrick Kesslak; Thomas Kieber-Emmons; Carl W Cotman; Michael G Agadjanyan
Adjuvant-dependent modulation of Th1 and Th2 responses to immunization with beta-amyloid.
International immunology 2003;15(4):505-14.
2003: Irina Petrushina; Mike Tran; Nadya Sadzikava; Anahit Ghochikyan; Vitaly Vasilevko; Michael G Agadjanyan; David H Cribbs
Importance of IgG2c isotype in the immune response to beta-amyloid in amyloid precursor protein/transgenic mice.
Neuroscience letters 2003;338(1):5-8.
2003: Ming Zhao; David H Cribbs; Aileen J Anderson; Brian John Cummings; Joseph H Su; Andrea J Wasserman; Carl W Cotman
The induction of the TNFalpha death domain signaling pathway in Alzheimer's disease brain.
Neurochemical research 2003;28(2):307-18.
2003: Vitaly Vasilevko; Anahit Ghochikyan; Nadya Sadzikava; Irina Petrushina; Mike Tran; Edward P Cohen; Patrick J Kesslak; David H Cribbs; Garth L Nicolson; Michael G Agadjanyan
Immunization with a vaccine that combines the expression of MUC1 and B7 co-stimulatory molecules prolongs the survival of mice and delays the appearance of mouse mammary tumors.
Clinical & experimental metastasis 2003;20(6):489-98.
2002: Elizabeth Head; Ira T Lott; David H Cribbs; Carl W Cotman; Troy T Rohn
Beta-amyloid deposition and neurofibrillary tangle association with caspase activation in Down syndrome.
Neuroscience letters 2002;330(1):99-103.
2001: Troy T Rohn; Elizabeth Head; W H Nesse; Carl W Cotman; David H Cribbs
Activation of caspase-8 in the Alzheimer's disease brain.
Neurobiology of disease 2001;8(6):1006-16.
2001: Elizabeth Head; BY Azizeh; Ira T Lott; Andrea J Tenner; Carl W Cotman; David H Cribbs
Complement association with neurons and beta-amyloid deposition in the brains of aged individuals with Down Syndrome.
Neurobiology of disease 2001;8(2):252-65.
2001: Troy T Rohn; S M Wong; Carl W Cotman; David H Cribbs
15-deoxy-delta12,14-prostaglandin J2, a specific ligand for peroxisome proliferator-activated receptor-gamma, induces neuronal apoptosis.
Neuroreport 2001;12(4):839-43.
2001: Patrick Callaerts; S Leng; Jason Clements; Corinne Benassayag; David H Cribbs; Yuan Yuan Kang; Uwe Walldorf; Karl-Friedrich Fischbach; R Strauss
Drosophila Pax-6/eyeless is essential for normal adult brain structure and function.
Journal of neurobiology 2001;46(2):73-88.
2001: Troy T Rohn; Elizabeth Head; Joseph H Su; Aileen J Anderson; Ben A Bahr; Carl W Cotman; David H Cribbs
Correlation between caspase activation and neurofibrillary tangle formation in Alzheimer's disease.
The American journal of pathology 2001;158(1):189-98.
2000: TA Davies; Heidi J Long; Patricia B Eisenhauer; R Hastey; David H Cribbs; Richard E Fine; Elizabeth R Simons
Beta amyloid fragments derived from activated platelets deposit in cerebrovascular endothelium: usage of a novel blood brain barrier endothelial cell model system.
Amyloid : the international journal of experimental and clinical investigation : the official journal of the International Society of Amyloidosis 2000;7(3):153-65.
2000: Troy T Rohn; KJ Ivins; Ben A Bahr; Carl W Cotman; David H Cribbs
A monoclonal antibody to amyloid precursor protein induces neuronal apoptosis.
Journal of neurochemistry 2000;74(6):2331-42.
2000: David H Cribbs; BY Azizeh; Carl W Cotman; Frank M LaFerla
Fibril formation and neurotoxicity by a herpes simplex virus glycoprotein B fragment with homology to the Alzheimer's A beta peptide.
Biochemistry 2000;39(20):5988-94.
1999: J Davis; David H Cribbs; Carl W Cotman; William E Van Nostrand
Pathogenic amyloid beta-protein induces apoptosis in cultured human cerebrovascular smooth muscle cells.
Amyloid : the international journal of experimental and clinical investigation : the official journal of the International Society of Amyloidosis 1999;6(3):157-64.
1999: Scott D Webster; Andrea J Tenner; T L Poulos; David H Cribbs
The mouse C1q A-chain sequence alters beta-amyloid-induced complement activation.
Neurobiology of aging 1999;20(3):297-304.
1998: TA Davies; AM Billingslea; Heidi J Long; HE Tibbles; John M Wells; Patricia B Eisenhauer; SJ Smith; David H Cribbs; Richard E Fine; Elizabeth R Simons
Brain endothelial cell enzymes cleave platelet-retained amyloid precursor protein.
The Journal of laboratory and clinical medicine 1998;132(4):341-50.
1998: Elizabeth R Simons; DC Marshall; Heidi J Long; K Otto; AM Billingslea; HE Tibbles; J Wells; Patricia B Eisenhauer; Richard E Fine; David H Cribbs; TA Davies; Carmela Abraham
Blood brain barrier endothelial cells express candidate amyloid precursor protein-cleaving secretases.
Amyloid : the international journal of experimental and clinical investigation : the official journal of the International Society of Amyloidosis 1998;5(3):153-62.
1998: David A Stenger; J J Hickman; K E Bateman; M S Ravenscroft; Wu Ma; Joseph Pancrazio; Kara M Shaffer; A E Schaffner; David H Cribbs; Carl W Cotman
Microlithographic determination of axonal/dendritic polarity in cultured hippocampal neurons.
Journal of neuroscience methods 1998;82(2):167-73.
1998: BY Azizeh; David H Cribbs; V M Kreng; Carl W Cotman
Cross-linking of NCAM receptors on neurons induces programmed cell death.
Brain research 1998;796(1-2):20-6.
1997: David H Cribbs; Peter Velazquez; Brian A Soreghan; Charles G Glabe; Andrea J Tenner
Complement activation by cross-linked truncated and chimeric full-length beta-amyloid.
Neuroreport 1997;8(16):3457-62.
1997: T Satou; Brian John Cummings; Elizabeth Head; K A Nielson; Fletcher Hahn; Norton W Milgram; Peter Velazquez; David H Cribbs; Andrea J Tenner; Carl W Cotman
The progression of beta-amyloid deposition in the frontal cortex of the aged canine.
Brain research 1997;774(1-2):35-43.
1997: David H Cribbs; Christian J Pike; S L Weinstein; Peter Velazquez; Carl W Cotman
All-D-enantiomers of beta-amyloid exhibit similar biological properties to all-L-beta-amyloids.
The Journal of biological chemistry 1997;272(11):7431-6.
1997: L L Weber; Malcolm Leissring; Austin Yang; Charles G Glabe; David H Cribbs; Frank M LaFerla
Presenilin-1 immunoreactivity is localized intracellularly in Alzheimer's disease brain, but not detected in amyloid plaques.
Experimental neurology 1997;143(1):37-44.
1997: Peter Velazquez; David H Cribbs; T L Poulos; Andrea J Tenner
Aspartate residue 7 in amyloid beta-protein is critical for classical complement pathway activation: implications for Alzheimer's disease pathogenesis.
Nature medicine 1997;3(1):77-9.
1996: David H Cribbs; V M Kreng; A J Anderson; Carl W Cotman
Cross-linking of concanavalin A receptors on cortical neurons induces programmed cell death.
Neuroscience 1996;75(1):173-85.
1996: David H Cribbs; L S Chen; Carl W Cotman; Frank M LaFerla
Injury induces presenilin-1 gene expression in mouse brain.
Neuroreport 1996;7(11):1773-6.
1996: David H Cribbs; L S Chen; S M Bende; Frank M LaFerla
Widespread neuronal expression of the presenilin-1 early-onset Alzheimer's disease gene in the murine brain.
The American journal of pathology 1996;148(6):1797-806.
1996: A Afagh; Brian John Cummings; David H Cribbs; Carl W Cotman; Andrea J Tenner
Localization and cell association of C1q in Alzheimer's disease brain.
Experimental neurology 1996;138(1):22-32.
1995: A G Woods; David H Cribbs; Edward R Whittemore; Carl W Cotman
Heparan sulfate and chondroitin sulfate glycosaminoglycan attenuate beta-amyloid(25-35) induced neurodegeneration in cultured hippocampal neurons.
Brain research 1995;697(1-2):53-62.
1995: A R Korotzer; J Watt; David H Cribbs; Andrea J Tenner; D Burdick; Charles G Glabe; Carl W Cotman
Cultured rat microglia express C1q and receptor for C1q: implications for amyloid effects on microglia.
Experimental neurology 1995;134(2):214-21.
1995: Christian J Pike; A J Walencewicz-Wasserman; J Kosmoski; David H Cribbs; Charles G Glabe; Carl W Cotman
Structure-activity analyses of beta-amyloid peptides: contributions of the beta 25-35 region to aggregation and neurotoxicity.
Journal of neurochemistry 1995;64(1):253-65.
1994: M D Smyth; David H Cribbs; Andrea J Tenner; W. Rodman Shankle; M Dick; J P Kesslak; Carl W Cotman
Decreased levels of C1q in cerebrospinal fluid of living Alzheimer patients correlate with disease state.
Neurobiology of aging 1994;15(5):609-14.
1991: David A Stenger; David H Cribbs; T L Fare
Modulation of a gated ion channel admittance in lipid bilayer membranes.
Biosensors & bioelectronics 1991;6(5):425-30.
1984: D C Lin; K D Tobin; David H Cribbs
On the mechanism for inactivation of cytochalasin binding activity associated with F-actin and spectrin-band 4.1-actin complex by sulfhydryl reagents.
Biochemical and biophysical research communications 1984;122(1):244-51.
1982: S Lin; David H Cribbs; J A Wilkins; James F Casella; W W Magargal; D C Lin
The capactins, a class of proteins that cap the ends of actin filaments.
Philosophical transactions of the Royal Society of London. Series B, Biological sciences 1982;299(1095):263-73.
1982: David H Cribbs; J R Glenney; P Kaulfus; K Weber; S Lin
Interaction of cytochalasin B with actin filaments nucleated or fragmented by villin.
The Journal of biological chemistry 1982;257(1):395-9.
1982: S Lin; J A Wilkins; David H Cribbs; M Grumet; D C Lin
Proteins and complexes that affect actin-filament assembly and interactions.
Cold Spring Harbor symposia on quantitative biology 1982;46 Pt 2():625-32.