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David Critchley

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Chemicals & Drugs

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Benjamin T Goult; Fiona Hey; Gordon C K Roberts; Ricky Tsang; Thomas Zacharchenko; Neil Bate; David R Critchley; Paul R Elliott; Alexandre R Gingras; Christoph Ballestrem; Igor L Barsukov
RIAM and vinculin binding to talin are mutually exclusive and regulate adhesion assembly and turnover.
Wei Zou; Tingting Zhu; Jean Chappel; David R Critchley; Mark H Ginsberg; Takashi Izawa; Susan J Monkley; Alexei Morozov; Karel Otero; Brian Petrich; Steven L Teitelbaum
Talin1 and Rap1 are critical for osteoclast function.
Emmanuel Debrand; Daniela Mazzeo; Susan J Monkley; Catrin A Pritchard; Lorraine Spence; Neil Bate; Francesco J Conti; David R Critchley
Mice carrying a complete deletion of the talin2 coding sequence are viable and fertile.

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2013: Benjamin T Goult; Fiona Hey; Gordon C K Roberts; Ricky Tsang; Thomas Zacharchenko; Neil Bate; David R Critchley; Paul R Elliott; Alexandre R Gingras; Christoph Ballestrem; Igor L Barsukov
RIAM and vinculin binding to talin are mutually exclusive and regulate adhesion assembly and turnover.
The Journal of biological chemistry 2013;288(12):8238-49.
2013: Wei Zou; Tingting Zhu; Jean Chappel; David R Critchley; Mark H Ginsberg; Takashi Izawa; Susan J Monkley; Alexei Morozov; Karel Otero; Brian Petrich; Steven L Teitelbaum
Talin1 and Rap1 are critical for osteoclast function.
Molecular and cellular biology 2013;33(4):830-44.
2012: Emmanuel Debrand; Daniela Mazzeo; Susan J Monkley; Catrin A Pritchard; Lorraine Spence; Neil Bate; Francesco J Conti; David R Critchley
Mice carrying a complete deletion of the talin2 coding sequence are viable and fertile.
Biochemical and biophysical research communications 2012;426(2):190-5.
2012: Craig T Lefort; David R Critchley; Reinhard Fässler; Mark H Ginsberg; Susan J Monkley; Markus Moser; Brian Petrich; Jan Rossaint; Alexander Zarbock; Klaus Ley
Distinct roles for talin-1 and kindlin-3 in LFA-1 extension and affinity regulation.
Blood 2012;119(18):4275-82.
2012: Asoka Banno; Neil Bate; David R Critchley; Benjamin T Goult; HoSup Lee; Mark H Ginsberg
Subcellular localization of talin is regulated by inter-domain interactions.
The Journal of biological chemistry 2012;287(17):13799-812.
2012: Uta Praekelt; Kerstin Rehm; Robert S Ross; Roy Zent; Ming-Zhi Zhang; Bipin Patel; Neil Bate; Franceso Conti; David R Critchley; Emmanuel Debrand; Raymond C Harris; Petra M Kopp; Stefan Linder; Ana Maria Manso; Susan J Monkley
New isoform-specific monoclonal antibodies reveal different sub-cellular localisations for talin1 and talin2.
European journal of cell biology 2012;91(3):180-91.
2012: Neil Bate; Alexia Bachir; Alexandre R Gingras; Benjamin T Goult; Rick Horwitz; Bipin Patel; Feng Ye; David R Critchley
Talin contains a C-terminal calpain2 cleavage site important in focal adhesion dynamics.
PloS one 2012;7(4):e34461.
2011: Jie Liu; Stephen F Lowry; Susan J Monkley; Yanmei Qi; Xiaoxiang Tian; Siobhan A Corbett; David R Critchley; Alan M Graham; Xiaowen He; Shaohua Li
Talin1 regulates integrin turnover to promote embryonic epithelial morphogenesis.
Molecular and cellular biology 2011;31(16):3366-77.
2011: Dale Powner; Petra M Kopp; Susan J Monkley; David R Critchley; Fedor Berditchevski
Tetraspanin CD9 in cell migration.
Biochemical Society transactions 2011;39(2):563-7.
2011: Jacob R Haling; Susan J Monkley; David R Critchley; Brian Petrich
Talin-dependent integrin activation is required for fibrin clot retraction by platelets.
Blood 2011;117(5):1719-22.
2011: Susan J Monkley; Vassiliki Kostourou; Lorraine Spence; Brian Petrich; Stacey Coleman; Mark H Ginsberg; Catrin A Pritchard; David R Critchley
Endothelial cell talin1 is essential for embryonic angiogenesis.
Developmental biology 2011;349(2):494-502.
2010: Eugenia Manevich-Mendelson; Valentin Grabovsky; Sara W Feigelson; Guy Cinamon; Yael Gore; Gera Goverse; Susan J Monkley; Raanan Margalit; Doron Melamed; Reina E Mebius; David R Critchley; Idit Shachar; Ronen Alon
Talin1 is required for integrin-dependent B lymphocyte homing to lymph nodes and the bone marrow but not for follicular B-cell maturation in the spleen.
Blood 2010;116(26):5907-18.
2010: Nicholas J Anthis; Kate L Wegener; David R Critchley; Iain D Campbell
Structural diversity in integrin/talin interactions.
Structure (London, England : 1993) 2010;18(12):1654-66.
2010: Jenson Lim; Aurélien Dupuy; David R Critchley; Emmanuelle Caron
Rap1 controls activation of the α(M)β(2) integrin in a talin-dependent manner.
Journal of cellular biochemistry 2010;111(4):999-1009.
2010: Alexandre R Gingras; Neil Bate; Benjamin T Goult; Bipin Patel; Petra M Kopp; Jonas Emsley; Igor L Barsukov; Gordon C K Roberts; David R Critchley
Central region of talin has a unique fold that binds vinculin and actin.
The Journal of biological chemistry 2010;285(38):29577-87.
2010: Petra M Kopp; Neil Bate; Tania Wilmann; Nicholas P J Brindle; Uta Praekelt; Emmanuel Debrand; Stacey Coleman; Daniela Mazzeo; Benjamin T Goult; Alexandre R Gingras; Catrin A Pritchard; David R Critchley; Susan J Monkley
Studies on the morphology and spreading of human endothelial cells define key inter- and intramolecular interactions for talin1.
European journal of cell biology 2010;89(9):661-73.
2010: Benjamin T Goult; Alexandre R Gingras; Neil Bate; Igor L Barsukov; David R Critchley; Gordon Roberts
The domain structure of talin: residues 1815-1973 form a five-helix bundle containing a cryptic vinculin-binding site.
FEBS letters 2010;584(11):2237-41.
2010: Benjamin T Goult; Mohamed Bouaouina; Paul R Elliott; Neil Bate; Bipin Patel; Alexandre R Gingras; J Günter Grossmann; Gordon Roberts; David A Calderwood; David R Critchley; Igor L Barsukov
Structure of a double ubiquitin-like domain in the talin head: a role in integrin activation.
The EMBO journal 2010;29(6):1069-80.
2010: Katherine Clark; Jonathan D Howe; Christine E Pullar; J Angelo Green; Vira V Artym; Kenneth M Yamada; David R Critchley
Tensin 2 modulates cell contractility in 3D collagen gels through the RhoGAP DLC1.
Journal of cellular biochemistry 2010;109(4):808-17.
2009: Benjamin T Goult; Mohamed Bouaouina; David S Harburger; Neil Bate; Bipin Patel; Nicholas J Anthis; Iain D Campbell; David A Calderwood; Igor L Barsukov; Gordon Roberts; David R Critchley
The structure of the N-terminus of kindlin-1: a domain important for alphaiibbeta3 integrin activation.
Journal of molecular biology 2009;394(5):944-56.
2009: Nicholas J Anthis; Kate L Wegener; Feng Ye; Chungho Kim; Benjamin T Goult; Edward D Lowe; Ioannis Vakonakis; Neil Bate; David R Critchley; Mark H Ginsberg; Iain D Campbell
The structure of an integrin/talin complex reveals the basis of inside-out signal transduction.
The EMBO journal 2009;28(22):3623-32.
2009: Benjamin T Goult; Neil Bate; Nicholas J Anthis; Kate L Wegener; Alexandre R Gingras; Bipin Patel; Igor L Barsukov; Iain D Campbell; Gordon Roberts; David R Critchley
The structure of an interdomain complex that regulates talin activity.
The Journal of biological chemistry 2009;284(22):15097-106.
2009: Alexandre R Gingras; Wolfgang H Ziegler; Andrey A Bobkov; M Gordon Joyce; Domenico Fasci; Mirko Himmel; Sven Rothemund; Anett Ritter; J Günter Grossmann; Bipin Patel; Neil Bate; Benjamin T Goult; Jonas Emsley; Igor L Barsukov; Gordon Roberts; Robert C Liddington; Mark H Ginsberg; David R Critchley
Structural determinants of integrin binding to the talin rod.
The Journal of biological chemistry 2009;284(13):8866-76.
2009: Emmanuel Debrand; Yasmine El Jai; Lorraine Spence; Neil Bate; Uta Praekelt; Catrin A Pritchard; Susan J Monkley; David R Critchley
Talin 2 is a large and complex gene encoding multiple transcripts and protein isoforms.
The FEBS journal 2009;276(6):1610-28.
2009: Emily Mace; Susan J Monkley; David R Critchley; Fumio Takei
A dual role for talin in NK cell cytotoxicity: activation of LFA-1-mediated cell adhesion and polarization of NK cells.
Journal of immunology (Baltimore, Md. : 1950) 2009;182(2):948-56.
2009: David R Critchley
Biochemical and structural properties of the integrin-associated cytoskeletal protein talin.
Annual review of biophysics 2009;38():235-54.
2008: Mark Holt; Yolanda Calle; D H Sutton; David R Critchley; Gareth E Jones; Graham A Dunn
Quantifying cell-matrix adhesion dynamics in living cells using interference reflection microscopy.
Journal of microscopy 2008;232(1):73-81.
2008: Kate L Wegener; Jaswir Basran; Clive R Bagshaw; Iain D Campbell; Gordon Roberts; David R Critchley; Igor L Barsukov
Structural basis for the interaction between the cytoplasmic domain of the hyaluronate receptor layilin and the talin F3 subdomain.
Journal of molecular biology 2008;382(1):112-26.
2008: Xian Zhang; Guoying Jiang; Yunfei Cai; Susan J Monkley; David R Critchley; Michael P Sheetz
Talin depletion reveals independence of initial cell spreading from integrin activation and traction.
Nature cell biology 2008;10(9):1062-8.
2008: Benjamin T Goult; Alexandre R Gingras; Neil Bate; Gordon Roberts; David R Critchley; Igor L Barsukov
NMR assignment of the C-terminal actin-binding domain of talin.
Biomolecular NMR assignments 2008;2(1):17-9.
2008: Tim Lämmermann; Bernhard L Bader; Susan J Monkley; Tim Worbs; Roland Wedlich-Söldner; Karin Hirsch; Markus Keller; Reinhold Förster; David R Critchley; Reinhard Fässler; Michael Sixt
Rapid leukocyte migration by integrin-independent flowing and squeezing.
Nature 2008;453(7191):51-5.
2008: David R Critchley; Alexandre R Gingras
Talin at a glance.
Journal of cell science 2008;121(Pt 9):1345-7.
2008: Ning Sun; David R Critchley; D Paulin; Zhenlin Li; Richard M Robson
Identification of a repeated domain within mammalian alpha-synemin that interacts directly with talin.
Experimental cell research 2008;314(8):1839-49.
2008: Wolfgang H Ziegler; Alex R Gingras; David R Critchley; jonas emsley
Integrin connections to the cytoskeleton through talin and vinculin.
Biochemical Society transactions 2008;36(Pt 2):235-9.
2008: Yanfeng Wang; Rustem I Litvinov; Xinsheng Chen; Tami L Bach; Lurong Lian; Brian Petrich; Susan J Monkley; Yasunori Kanaho; David R Critchley; Takehiko Sasaki; Morris J Birnbaum; John W Weisel; John Hartwig; Charles S Abrams
Loss of PIP5KIgamma, unlike other PIP5KI isoforms, impairs the integrity of the membrane cytoskeleton in murine megakaryocytes.
The Journal of clinical investigation 2008;118(2):812-9.
2008: Ning Sun; David R Critchley; D Paulin; Zhenlin Li; Richard M Robson
Human alpha-synemin interacts directly with vinculin and metavinculin.
The Biochemical journal 2008;409(3):657-67.
2008: Alexandre R Gingras; Neil Bate; Benjamin T Goult; Larnele Hazelwood; Ilona Canestrelli; J Günter Grossmann; HongJun Liu; Nicholas S M Putz; Gordon Roberts; Niels Volkmann; Dorit Hanein; Igor L Barsukov; David R Critchley
The structure of the C-terminal actin-binding domain of talin.
The EMBO journal 2008;27(2):458-69.
2007: Bernhard Nieswandt; Markus Moser; Irina Pleines; David Varga-Szabo; Sue Monkley; David R Critchley; Reinhard Fässler
Loss of talin1 in platelets abrogates integrin activation, platelet aggregation, and thrombus formation in vitro and in vivo.
The Journal of experimental medicine 2007;204(13):3113-8.
2007: Brian Petrich; Patrizia Marchese; Zaverio M Ruggeri; Saskia Spiess; Rachel A M Weichert; Feng Ye; Ralph Tiedt; Radek C Skoda; Susan J Monkley; David R Critchley; Mark H Ginsberg
Talin is required for integrin-mediated platelet function in hemostasis and thrombosis.
The Journal of experimental medicine 2007;204(13):3103-11.
2007: Michèle Moes; Sophie Rodius; Stacey J Coleman; Susan J Monkley; Erik Goormaghtigh; Laurent Tremuth; Corinne Kox; Patrick P G van der Holst; David R Critchley; NELLY KIEFFER
The integrin binding site 2 (IBS2) in the talin rod domain is essential for linking integrin beta subunits to the cytoskeleton.
The Journal of biological chemistry 2007;282(23):17280-8.
2007: Jenson Lim; Agnès Wiedemann; George Tzircotis; Susan J Monkley; David R Critchley; Emmanuelle Caron
An essential role for talin during alpha(M)beta(2)-mediated phagocytosis.
Molecular biology of the cell 2007;18(3):976-85.
2006: Wolfgang H Ziegler; Robert C Liddington; David R Critchley
The structure and regulation of vinculin.
Trends in cell biology 2006;16(9):453-60.
2006: Ruth M Saunders; Mark Holt; Lisa Jennings; Deborah H Sutton; Igor L Barsukov; Andrey A Bobkov; Robert C Liddington; Eileen A Adamson; Graham A Dunn; David R Critchley
Role of vinculin in regulating focal adhesion turnover.
European journal of cell biology 2006;85(6):487-500.
2006: Bipin Patel; Alexandre R Gingras; Andrey A Bobkov; L Miya Fujimoto; Man Zhang; Robert C Liddington; Daniela Mazzeo; Jonas Emsley; Gordon Roberts; Igor L Barsukov; David R Critchley
The activity of the vinculin binding sites in talin is influenced by the stability of the helical bundles that make up the talin rod.
The Journal of biological chemistry 2006;281(11):7458-67.
2006: Alexandre R Gingras; Klaus-Peter Vogel; Heinz-Jürgen Steinhoff; Wolfgang H Ziegler; Bipin Patel; Jonas Emsley; David R Critchley; Gordon Roberts; Igor L Barsukov
Structural and dynamic characterization of a vinculin binding site in the talin rod.
Biochemistry 2006;45(6):1805-17.
2005: David R Critchley
Genetic, biochemical and structural approaches to talin function.
Biochemical Society transactions 2005;33(Pt 6):1308-12.
2005: Alexandre R Gingras; Wolfgang H Ziegler; Ronald Frank; Igor L Barsukov; Gordon Roberts; David R Critchley; Jonas Emsley
Mapping and consensus sequence identification for multiple vinculin binding sites within the talin rod.
The Journal of biological chemistry 2005;280(44):37217-24.
2005: Alison J Woods; Theo Kantidakis; Hisataka Sabe; David R Critchley; Jim C Norman
Interaction of paxillin with poly(A)-binding protein 1 and its role in focal adhesion turnover and cell migration.
Molecular and cellular biology 2005;25(9):3763-73.
2005: Jose M de Pereda; Kate L Wegener; Eugenio Santelli; Neil Bate; Mark H Ginsberg; David R Critchley; Iain D Campbell; Robert C Liddington
Structural basis for phosphatidylinositol phosphate kinase type Igamma binding to talin at focal adhesions.
The Journal of biological chemistry 2005;280(9):8381-6.
2005: Ian J Fillingham; Alexandre R Gingras; Evangelos Papagrigoriou; Bipin Patel; Jonas Emsley; David R Critchley; Gordon Roberts; Igor L Barsukov
A vinculin binding domain from the talin rod unfolds to form a complex with the vinculin head.
Structure (London, England : 1993) 2005;13(1):65-74.
2004: David R Critchley
Cytoskeletal proteins talin and vinculin in integrin-mediated adhesion.
Biochemical Society transactions 2004;32(Pt 5):831-6.
2004: Ho-Sup Lee; Robert M Bellin; Diane L Walker; Bipin Patel; Pam Powers; Hongjun Liu; Begoña Garcia-Alvarez; Jose M de Pereda; Robert C Liddington; Niels Volkmann; Dorit Hanein; David R Critchley; Richard M Robson
Characterization of an actin-binding site within the talin FERM domain.
Journal of molecular biology 2004;343(3):771-84.
2004: Evangelos Papagrigoriou; Alexandre R Gingras; Igor L Barsukov; Neil Bate; Ian J Fillingham; Bipin Patel; Ronald Frank; Wolfgang H Ziegler; Gordon Roberts; David R Critchley; Jonas Emsley
Activation of a vinculin-binding site in the talin rod involves rearrangement of a five-helix bundle.
The EMBO journal 2004;23(15):2942-51.
2004: Constantina Bakolitsa; Daniel M Cohen; Laurie A Bankston; Andrey A Bobkov; Gregory W Cadwell; Lisa Jennings; David R Critchley; Susan W Craig; Robert C Liddington
Structural basis for vinculin activation at sites of cell adhesion.
Nature 2004;430(6999):583-6.
2003: Grégory Giannone; Guoying Jiang; Deborah H Sutton; David R Critchley; Michael P Sheetz
Talin1 is critical for force-dependent reinforcement of initial integrin-cytoskeleton bonds but not tyrosine kinase activation.
The Journal of cell biology 2003;163(2):409-19.
2003: Igor L Barsukov; Andrew Prescot; Neil Bate; Bipin Patel; David N Floyd; Nina Bhanji; Clive R Bagshaw; Kresimir Letinic; Gilbert Di Paolo; Pietro De Camilli; Gordon Roberts; David R Critchley
Phosphatidylinositol phosphate kinase type 1gamma and beta1-integrin cytoplasmic domain bind to the same region in the talin FERM domain.
The Journal of biological chemistry 2003;278(33):31202-9.
2003: Guoying Jiang; Grégory Giannone; David R Critchley; Emiko Fukumoto; Michael P Sheetz
Two-piconewton slip bond between fibronectin and the cytoskeleton depends on talin.
Nature 2003;424(6946):334-7.
2003: Begoña García-Alvarez; Jose M de Pereda; David A Calderwood; Tobias S Ulmer; David R Critchley; Iain D Campbell; Mark H Ginsberg; Robert C Liddington
Structural determinants of integrin recognition by talin.
Molecular cell 2003;11(1):49-58.
2002: Mark D Bass; Bipin Patel; Igor Barsukov; Ian J Fillingham; Robert Mason; Beverley J Smith; Clive R Bagshaw; David R Critchley
Further characterization of the interaction between the cytoskeletal proteins talin and vinculin.
The Biochemical journal 2002;362(Pt 3):761-8.
2002: Alison J Woods; Marnie S Roberts; Jyoti Choudhary; Simon T Barry; Yuichi Mazaki; Hisataka Sabe; Simon J Morley; David R Critchley; Jim C Norman
Paxillin associates with poly(A)-binding protein 1 at the dense endoplasmic reticulum and the leading edge of migrating cells.
The Journal of biological chemistry 2002;277(8):6428-37.
2001: Susan J Monkley; Catrin A Pritchard; David R Critchley
Analysis of the mammalian talin2 gene TLN2.
Biochemical and biophysical research communications 2001;286(5):880-5.
2001: Robert M Bellin; Ted W Huiatt; David R Critchley; Richard M Robson
Synemin may function to directly link muscle cell intermediate filaments to both myofibrillar Z-lines and costameres.
The Journal of biological chemistry 2001;276(34):32330-7.
2000: Susan J Monkley; X H Zhou; S J Kinston; Susan Giblett; L Hemmings; H Priddle; JE Brown; Catrin A Pritchard; David R Critchley; R Fässler
Disruption of the talin gene arrests mouse development at the gastrulation stage.
Developmental dynamics : an official publication of the American Association of Anatomists 2000;219(4):560-74.
2000: David R Critchley
Focal adhesions - the cytoskeletal connection.
Current opinion in cell biology 2000;12(1):133-9.
1999: Constantina Bakolitsa; Jose M de Pereda; Clive R Bagshaw; David R Critchley; Robert C Liddington
Crystal structure of the vinculin tail suggests a pathway for activation.
Cell 1999;99(6):603-13.
1999: M D Bass; B J Smith; Sally A Prigent; David R Critchley
Talin contains three similar vinculin-binding sites predicted to form an amphipathic helix.
The Biochemical journal 1999;341 ( Pt 2)():257-63.
1999: David R Critchley; Mark Holt; Simon T Barry; H Priddle; L Hemmings; J Norman
Integrin-mediated cell adhesion: the cytoskeletal connection.
Biochemical Society symposium 1999;65():79-99.
1998: Jim C Norman; David Jones; Simon T Barry; Mark Holt; Shamshad Cockcroft; David R Critchley
ARF1 mediates paxillin recruitment to focal adhesions and potentiates Rho-stimulated stress fiber formation in intact and permeabilized Swiss 3T3 fibroblasts.
The Journal of cell biology 1998;143(7):1981-95.
1998: H Priddle; L Hemmings; Susan J Monkley; A Woods; Bipin Patel; D Sutton; Graham A Dunn; Daniel Zicha; David R Critchley
Disruption of the talin gene compromises focal adhesion assembly in undifferentiated but not differentiated embryonic stem cells.
The Journal of cell biology 1998;142(4):1121-33.
1998: Mark Holt; David R Critchley; Nicholas P J Brindle
The focal adhesion phosphoprotein, VASP.
The international journal of biochemistry & cell biology 1998;30(3):307-11.
1997: Simon T Barry; H M Flinn; M J Humphries; David R Critchley; A J Ridley
Requirement for Rho in integrin signalling.
Cell adhesion and communication 1997;4(6):387-98.
1997: S J Bolton; Simon T Barry; H Mosley; Bipin Patel; B M Jockusch; J M Wilkinson; David R Critchley
Monoclonal antibodies recognizing the N- and C-terminal regions of talin disrupt actin stress fibers when microinjected into human fibroblasts.
Cell motility and the cytoskeleton 1997;36(4):363-76.
1996: SAVERIO FRANCESCO RETTA; Simon T Barry; David R Critchley; Paola Defilippi; Lorenzo Silengo; Guido Tarone
Focal adhesion and stress fiber formation is regulated by tyrosine phosphatase activity.
Experimental cell research 1996;229(2):307-17.
1996: L Hemmings; D J Rees; V Ohanian; S J Bolton; A P Gilmore; Bipin Patel; H Priddle; J E Trevithick; R O Hynes; David R Critchley
Talin contains three actin-binding sites each of which is adjacent to a vinculin-binding site.
Journal of cell science 1996;109 ( Pt 11)():2715-26.
1996: Nicholas P J Brindle; Mark Holt; J E Davies; C J Price; David R Critchley
The focal-adhesion vasodilator-stimulated phosphoprotein (VASP) binds to the proline-rich domain in vinculin.
The Biochemical journal 1996;318 ( Pt 3)():753-7.
1996: J Weekes; Simon T Barry; David R Critchley
Acidic phospholipids inhibit the intramolecular association between the N- and C-terminal regions of vinculin, exposing actin-binding and protein kinase C phosphorylation sites.
The Biochemical journal 1996;314 ( Pt 3)():827-32.
1996: Elena P Moiseeva; Alexey M Belkin; N K Spurr; V E Koteliansky; David R Critchley
A novel dystrophin/utrophin-associated protein is an enzymatically inactive member of the phosphoglucomutase superfamily.
European journal of biochemistry / FEBS 1996;235(1-2):103-13.
1995: G Flood; E Kahana; A P Gilmore; Arthur J Rowe; Walter Gratzer; David R Critchley
Association of structural repeats in the alpha-actinin rod domain. Alignment of inter-subunit interactions.
Journal of molecular biology 1995;252(2):227-34.
1995: L Hemmings; Simon T Barry; David R Critchley
Cell-matrix adhesion: structure and regulation.
Biochemical Society transactions 1995;23(3):619-26.
1995: G J Flood; Walter Gratzer; E Kahana; Arthur J Rowe; David R Critchley
Association of structural repeats in alpha-actinin.
Biochemical Society transactions 1995;23(3):399S.
1995: S J Winder; L Hemmings; S J Bolton; S K Maciver; Jon Tinsley; Kay E Davies; David R Critchley; John Kendrick-Jones
Calmodulin regulation of utrophin actin binding.
Biochemical Society transactions 1995;23(3):397S.
1995: A P Gilmore; V Ohanian; N K Spurr; David R Critchley
Localisation of the human gene encoding the cytoskeletal protein talin to chromosome 9p.
Human genetics 1995;96(2):221-4.
1995: S J Winder; L Hemmings; S K Maciver; S J Bolton; Jon Tinsley; Kay E Davies; David R Critchley; John Kendrick-Jones
Utrophin actin binding domain: analysis of actin binding and cellular targeting.
Journal of cell science 1995;108 ( Pt 1)():63-71.
1994: A P Gilmore; T Parr; Bipin Patel; Walter Gratzer; David R Critchley
Analysis of the phasing of four spectrin-like repeats in alpha-actinin.
European journal of biochemistry / FEBS 1994;225(1):235-42.
1994: A McGregor; A D Blanchard; Arthur J Rowe; David R Critchley
Identification of the vinculin-binding site in the cytoskeletal protein alpha-actinin.
The Biochemical journal 1994;301 ( Pt 1)():225-33.
1994: Simon T Barry; David R Critchley
The RhoA-dependent assembly of focal adhesions in Swiss 3T3 cells is associated with increased tyrosine phosphorylation and the recruitment of both pp125FAK and protein kinase C-delta to focal adhesions.
Journal of cell science 1994;107 ( Pt 7)():2033-45.
1994: Philip A Kuhlman; J Ellis; David R Critchley; Clive R Bagshaw
The kinetics of the interaction between the actin-binding domain of alpha-actinin and F-actin.
FEBS letters 1994;339(3):297-301.
1994: C K Wood; C E Turner; P Jackson; David R Critchley
Characterisation of the paxillin-binding site and the C-terminal focal adhesion targeting sequence in vinculin.
Journal of cell science 1994;107 ( Pt 2)():709-17.
1993: A P Gilmore; C Wood; V Ohanian; P Jackson; Bipin Patel; D J Rees; R O Hynes; David R Critchley
The cytoskeletal protein talin contains at least two distinct vinculin binding domains.
The Journal of cell biology 1993;122(2):337-47.
1993: E P Moiseyeva; P A Weller; N I Zhidkova; E B Corben; Bipin Patel; I Jasinska; V E Koteliansky; David R Critchley
Organization of the human gene encoding the cytoskeletal protein vinculin and the sequence of the vinculin promoter.
The Journal of biological chemistry 1993;268(6):4318-25.
1992: T Parr; G T Waites; Bipin Patel; D B Millake; David R Critchley
A chick skeletal-muscle alpha-actinin gene gives rise to two alternatively spliced isoforms which differ in the EF-hand Ca(2+)-binding domain.
European journal of biochemistry / FEBS 1992;210(3):801-9.
1992: A P Gilmore; P Jackson; G T Waites; David R Critchley
Further characterisation of the talin-binding site in the cytoskeletal protein vinculin.
Journal of cell science 1992;103 ( Pt 3)():719-31.
1992: Philip A Kuhlman; L Hemmings; David R Critchley
The identification and characterisation of an actin-binding site in alpha-actinin by mutagenesis.
FEBS letters 1992;304(2-3):201-6.
1992: V E Koteliansky; E P Ogryzko; N I Zhidkova; P A Weller; David R Critchley; K Vancompernolle; J Vandekerckhove; P Strasser; M Way; Mario Gimona
An additional exon in the human vinculin gene specifically encodes meta-vinculin-specific difference peptide. Cross-species comparison reveals variable and conserved motifs in the meta-vinculin insert.
European journal of biochemistry / FEBS 1992;205(3):1218.
1992: G T Waites; I R Graham; P Jackson; D B Millake; Bipin Patel; A D Blanchard; P A Weller; Ian C Eperon; David R Critchley
Mutually exclusive splicing of calcium-binding domain exons in chick alpha-actinin.
The Journal of biological chemistry 1992;267(9):6263-71.
1992: L Hemmings; Philip A Kuhlman; David R Critchley
Analysis of the actin-binding domain of alpha-actinin by mutagenesis and demonstration that dystrophin contains a functionally homologous domain.
The Journal of cell biology 1992;116(6):1369-80.
1992: V E Koteliansky; E P Ogryzko; N I Zhidkova; P A Weller; David R Critchley; K Vancompernolle; J Vandekerckhove; P Strasser; M Way; Mario Gimona
An additional exon in the human vinculin gene specifically encodes meta-vinculin-specific difference peptide. Cross-species comparison reveals variable and conserved motifs in the meta-vinculin insert.
European journal of biochemistry / FEBS 1992;204(2):767-72.
1991: David R Critchley; A Gilmore; L Hemmings; P Jackson; A McGregor; V Ohanian; Bipin Patel; G Waites; C Wood
Cytoskeletal proteins in adherens-type cell-matrix junctions.
Biochemical Society transactions 1991;19(4):1028-33.
1991: S L Griffiths; David R Critchley
Characterisation of the binding sites for Escherichia coli heat-labile toxin type I in intestinal brush borders.
Biochimica et biophysica acta 1991;1075(2):154-61.
1990: P A Weller; E P Ogryzko; E B Corben; N I Zhidkova; Bipin Patel; G J Price; N K Spurr; V E Koteliansky; David R Critchley
Complete sequence of human vinculin and assignment of the gene to chromosome 10.
Proceedings of the National Academy of Sciences of the United States of America 1990;87(15):5667-71.
1989: P Jones; P Jackson; G J Price; Bipin Patel; V Ohanion; A L Lear; David R Critchley
Identification of a talin binding site in the cytoskeletal protein vinculin.
The Journal of cell biology 1989;109(6 Pt 1):2917-27.
1989: P Jackson; G Smith; David R Critchley
Expression of a muscle-type alpha-actinin cDNA clone in non-muscle cells.
European journal of cell biology 1989;50(1):162-9.
1989: D B Millake; A D Blanchard; Bipin Patel; David R Critchley
The cDNA sequence of a human placental alpha-actinin.
Nucleic acids research 1989;17(16):6725.
1989: G J Price; P Jones; M D Davison; Bipin Patel; R Bendori; B Geiger; David R Critchley
Primary sequence and domain structure of chicken vinculin.
The Biochemical journal 1989;259(2):453-61.
1989: M D Davison; M D Baron; David R Critchley; J C Wootton
Structural analysis of homologous repeated domains in alpha-actinin and spectrin.
International journal of biological macromolecules 1989;11(2):81-90.
1989: Robert Parton; M D Davison; David R Critchley
Comparison of the binding characteristics of two different preparations of tetanus toxin to rat brain membranes.
Toxicon : official journal of the International Society on Toxinology 1989;27(1):127-35.
1988: Robert Parton; Colin D Ockleford; David R Critchley
Tetanus toxin binding to mouse spinal cord cells: an evaluation of the role of gangliosides in toxin internalization.
Brain research 1988;475(1):118-27.
1987: M D Baron; M D Davison; P Jones; David R Critchley
The sequence of chick alpha-actinin reveals homologies to spectrin and calmodulin.
The Journal of biological chemistry 1987;262(36):17623-9.
1987: M D Baron; M D Davison; P Jones; David R Critchley
The structure and function of alpha-actinin.
Biochemical Society transactions 1987;15(5):796-8.
1987: P Jones; G J Price; M D Davison; David R Critchley
Isolation and characterization of a vinculin cDNA from chick embryo fibroblasts.
Biochemical Society transactions 1987;15(5):794-6.
1987: Robert Parton; Colin D Ockleford; David R Critchley
A study of the mechanism of internalisation of tetanus toxin by primary mouse spinal cord cultures.
Journal of neurochemistry 1987;49(4):1057-68.
1987: G J Price; P Jones; M D Davison; Bipin Patel; Ian C Eperon; David R Critchley
Isolation and characterization of a vinculin cDNA from chick-embryo fibroblasts.
The Biochemical journal 1987;245(2):595-603.
1987: M D Baron; M D Davison; P Jones; B Patel; David R Critchley
Isolation and characterization of a cDNA encoding a chick alpha-actinin.
The Journal of biological chemistry 1987;262(6):2558-61.
1986: S L Griffiths; R A Finkelstein; David R Critchley
Characterization of the receptor for cholera toxin and Escherichia coli heat-labile toxin in rabbit intestinal brush borders.
The Biochemical journal 1986;238(2):313-22.
1986: E J Pierce; M D Davison; Robert Parton; W H Habig; David R Critchley
Characterization of tetanus toxin binding to rat brain membranes. Evidence for a high-affinity proteinase-sensitive receptor.
The Biochemical journal 1986;236(3):845-52.
1986: S L Griffiths; R M Perkins; C H Streuli; David R Critchley
Variants of BALB/c 3T3 cells lacking complex gangliosides retain a fibronectin matrix and spread normally on fibronectin-coated substrates.
The Journal of cell biology 1986;102(2):469-76.
1985: C H Streuli; S L Griffiths; David R Critchley
Isolation of variants of BALB/c 3T3 cells defective in complex ganglioside biosynthesis.
Experimental cell research 1985;156(1):260-70.
1982: R M Perkins; S Kellie; B Patel; David R Critchley
Gangliosides as receptors for fibronectin? Comparison of cell spreading on a ganglioside-specific ligand with that on fibronectin.
Experimental cell research 1982;141(2):231-43.