Paul Crocker

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TOP 3
Crocker Paul R; Redelinghuys Pierre
Siglecs as positive and negative regulators of the immune system.
McMillan Sarah J; Crocker Paul R
CD33-related sialic-acid-binding immunoglobulin-like lectins in health and disease.
Zucchini Nicolas; Bessou Gilles; Robbins Scott H; Chasson Lionel; Raper Anna; Crocker Paul R; Dalod Marc
Individual plasmacytoid dendritic cells are major contributors to the production of multiple innate cytokines in an organ-specific manner during viral infection.

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All Publications

2008: Crocker Paul R; Redelinghuys Pierre
Siglecs as positive and negative regulators of the immune system.
Biochemical Society transactions 2008;36(Pt 6):1467-71.
2008: McMillan Sarah J; Crocker Paul R
CD33-related sialic-acid-binding immunoglobulin-like lectins in health and disease.
Carbohydrate research 2008;343(12):2050-6.
2008: Zucchini Nicolas; Bessou Gilles; Robbins Scott H; Chasson Lionel; Raper Anna; Crocker Paul R; Dalod Marc
Individual plasmacytoid dendritic cells are major contributors to the production of multiple innate cytokines in an organ-specific manner during viral infection.
International immunology 2008;20(1):45-56.
2007: Delputte Peter L; Van Breedam Wander; Delrue Iris; Oetke Cornelia; Crocker Paul R; Nauwynck Hans J
Porcine arterivirus attachment to the macrophage-specific receptor sialoadhesin is dependent on the sialic acid-binding activity of the N-terminal immunoglobulin domain of sialoadhesin.
Journal of virology 2007;81(17):9546-50.
2007: Crocker Paul R; Paulson James C; Varki Ajit
Siglecs and their roles in the immune system.
Nature reviews. Immunology 2007;7(4):255-66.
2007: Zaccai Nathan R; May Andrew P; Robinson Robert C; Burtnick Leslie D; Crocker Paul R; Brossmer Reinhard; Kelm Soerge; Jones E Yvonne
Crystallographic and in silico analysis of the sialoside-binding characteristics of the Siglec sialoadhesin.
Journal of molecular biology 2007;365(5):1469-79.
2007: Biedermann Bjoern; Gil Diana; Bowen David T; Crocker Paul R
Analysis of the CD33-related siglec family reveals that Siglec-9 is an endocytic receptor expressed on subsets of acute myeloid leukemia cells and absent from normal hematopoietic progenitors.
Leukemia research 2007;31(2):211-20.
2007: Ip Chi Wang; Kroner Antje; Crocker Paul R; Nave Klaus-Armin; Martini Rudolf
Sialoadhesin deficiency ameliorates myelin degeneration and axonopathic changes in the CNS of PLP overexpressing mice.
Neurobiology of disease 2007;25(1):105-11.
2006: Avril T; Attrill H; Zhang J; Raper A; Crocker P R
Negative regulation of leucocyte functions by CD33-related siglecs.
Biochemical Society transactions 2006;34(Pt 6):1024-7.
2006: Attrill Helen; Imamura Akihiro; Sharma Ritu S; Kiso Makoto; Crocker Paul R; van Aalten Daan M F
Siglec-7 undergoes a major conformational change when complexed with the alpha(2,8)-disialylganglioside GT1b.
The Journal of biological chemistry 2006;281(43):32774-83.
2006: Avril Tony; North Simon J; Haslam Stuart M; Willison Hugh J; Crocker Paul R
Probing the cis interactions of the inhibitory receptor Siglec-7 with alpha2,8-disialylated ligands on natural killer cells and other leukocytes using glycan-specific antibodies and by analysis of alpha2,8-sialyltransferase gene expression.
Journal of leukocyte biology 2006;80(4):787-96.
2006: Jiang Hui-Rong; Hwenda Lenias; Makinen Kimmo; Oetke Cornelia; Crocker Paul R; Forrester John V
Sialoadhesin promotes the inflammatory response in experimental autoimmune uveoretinitis.
Journal of immunology (Baltimore, Md. : 1950) 2006;177(4):2258-64.
2006: Avril Tony; Wagner Eric R; Willison Hugh J; Crocker Paul R
Sialic acid-binding immunoglobulin-like lectin 7 mediates selective recognition of sialylated glycans expressed on Campylobacter jejuni lipooligosaccharides.
Infection and immunity 2006;74(7):4133-41.
2006: Oetke Cornelia; Kraal Georg; Crocker Paul R
The antigen recognized by MOMA-I is sialoadhesin.
Immunology letters 2006;106(1):96-8.
2006: Attrill Helen; Takazawa Hirokazu; Witt Simone; Kelm Soerge; Isecke Rainer; Brossmer Reinhard; Ando Takayuki; Ishida Hideharu; Kiso Makoto; Crocker Paul R; van Aalten Daan M F
The structure of siglec-7 in complex with sialosides: leads for rational structure-based inhibitor design.
The Biochemical journal 2006;397(2):271-8.
2006: Zhang Jiquan; Raper Anna; Sugita Noriko; Hingorani Ravi; Salio Mariolina; Palmowski Michael J; Cerundolo Vincenzo; Crocker Paul R
Characterization of Siglec-H as a novel endocytic receptor expressed on murine plasmacytoid dendritic cell precursors.
Blood 2006;107(9):3600-8.
2006: Oetke Cornelia; Vinson Mary C; Jones Claire; Crocker Paul R
Sialoadhesin-deficient mice exhibit subtle changes in B- and T-cell populations and reduced immunoglobulin M levels.
Molecular and cellular biology 2006;26(4):1549-57.
2005: Crocker Paul R
Siglecs in innate immunity.
Current opinion in pharmacology 2005;5(4):431-7.
2005: Avril Tony; Freeman Sylvie D; Attrill Helen; Clarke Rosemary G; Crocker Paul R
Siglec-5 (CD170) can mediate inhibitory signaling in the absence of immunoreceptor tyrosine-based inhibitory motif phosphorylation.
The Journal of biological chemistry 2005;280(20):19843-51.
2004: Avril Tony; Floyd Helen; Lopez Frederic; Vivier Eric; Crocker Paul R
The membrane-proximal immunoreceptor tyrosine-based inhibitory motif is critical for the inhibitory signaling mediated by Siglecs-7 and -9, CD33-related Siglecs expressed on human monocytes and NK cells.
Journal of immunology (Baltimore, Md. : 1950) 2004;173(11):6841-9.
2004: Zhang Jiquan Q; Biedermann Björn; Nitschke Lars; Crocker Paul R
The murine inhibitory receptor mSiglec-E is expressed broadly on cells of the innate immune system whereas mSiglec-F is restricted to eosinophils.
European journal of immunology 2004;34(4):1175-84.
2003: Jones Claire; Virji Mumtaz; Crocker Paul R
Recognition of sialylated meningococcal lipopolysaccharide by siglecs expressed on myeloid cells leads to enhanced bacterial uptake.
Molecular microbiology 2003;49(5):1213-25.
2003: Nicoll Gavin; Avril Tony; Lock Kevin; Furukawa Koichi; Bovin Nicolai; Crocker Paul R
Ganglioside GD3 expression on target cells can modulate NK cell cytotoxicity via siglec-7-dependent and -independent mechanisms.
European journal of immunology 2003;33(6):1642-8.
2003: Zaccai Nathan R; Maenaka Katsumi; Maenaka Taeko; Crocker Paul R; Brossmer Reinhard; Kelm Sørge; Jones E Yvonne
Structure-guided design of sialic acid-based Siglec inhibitors and crystallographic analysis in complex with sialoadhesin.
Structure (London, England : 1993) 2003;11(5):557-67.
2003: Alphey Magnus S; Attrill Helen; Crocker Paul R; van Aalten Daan M F
High resolution crystal structures of Siglec-7. Insights into ligand specificity in the Siglec family.
The Journal of biological chemistry 2003;278(5):3372-7.
2002: Crocker Paul R
Siglecs: sialic-acid-binding immunoglobulin-like lectins in cell-cell interactions and signalling.
Current opinion in structural biology 2002;12(5):609-15.
2002: Nakamura Kyoko; Yamaji Toshiyuki; Crocker Paul R; Suzuki Akemi; Hashimoto Yasuhiro
Lymph node macrophages, but not spleen macrophages, express high levels of unmasked sialoadhesin: implication for the adhesive properties of macrophages in vivo.
Glycobiology 2002;12(3):209-16.
2002: Yamaji Toshiyuki; Teranishi Takane; Alphey Magnus S; Crocker Paul R; Hashimoto Yasuhiro
A small region of the natural killer cell receptor, Siglec-7, is responsible for its preferred binding to alpha 2,8-disialyl and branched alpha 2,6-sialyl residues. A comparison with Siglec-9.
The Journal of biological chemistry 2002;277(8):6324-32.
2001: Crocker P R; Varki A
Siglecs, sialic acids and innate immunity.
Trends in immunology 2001;22(6):337-42.
2001: Munday J; Kerr S; Ni J; Cornish A L; Zhang J Q; Nicoll G; Floyd H; Mattei M G; Moore P; Liu D; Crocker P R
Identification, characterization and leucocyte expression of Siglec-10, a novel human sialic acid-binding receptor.
The Biochemical journal 2001;355(Pt 2):489-97.
2001: Nitschke L; Floyd H; Crocker P R
New functions for the sialic acid-binding adhesion molecule CD22, a member of the growing family of Siglecs.
Scandinavian journal of immunology 2001;53(3):227-34.
2000: Floyd H; Nitschke L; Crocker P R
A novel subset of murine B cells that expresses unmasked forms of CD22 is enriched in the bone marrow: implications for B-cell homing to the bone marrow.
Immunology 2000;101(3):342-7.
2000: Zhang J Q; Nicoll G; Jones C; Crocker P R
Siglec-9, a novel sialic acid binding member of the immunoglobulin superfamily expressed broadly on human blood leukocytes.
The Journal of biological chemistry 2000;275(29):22121-6.
2000: Floyd H; Ni J; Cornish A L; Zeng Z; Liu D; Carter K C; Steel J; Crocker P R
Siglec-8. A novel eosinophil-specific member of the immunoglobulin superfamily.
The Journal of biological chemistry 2000;275(2):861-6.
1999: Martínez-Pomares L; Crocker P R; Da Silva R; Holmes N; Colominas C; Rudd P; Dwek R; Gordon S
Cell-specific glycoforms of sialoadhesin and CD45 are counter-receptors for the cysteine-rich domain of the mannose receptor.
The Journal of biological chemistry 1999;274(49):35211-8.
1999: Munday J; Floyd H; Crocker P R
Sialic acid binding receptors (siglecs) expressed by macrophages.
Journal of leukocyte biology 1999;66(5):705-11.
1999: Nicoll G; Ni J; Liu D; Klenerman P; Munday J; Dubock S; Mattei M G; Crocker P R
Identification and characterization of a novel siglec, siglec-7, expressed by human natural killer cells and monocytes.
The Journal of biological chemistry 1999;274(48):34089-95.
1999: Crocker P R; Vinson M; Kelm S; Drickamer K
Molecular analysis of sialoside binding to sialoadhesin by NMR and site-directed mutagenesis.
The Biochemical journal 1999;341 ( Pt 2)():355-61.
1999: Nitschke L; Floyd H; Ferguson D J; Crocker P R
Identification of CD22 ligands on bone marrow sinusoidal endothelium implicated in CD22-dependent homing of recirculating B cells.
The Journal of experimental medicine 1999;189(9):1513-8.
1998: Cornish A L; Freeman S; Forbes G; Ni J; Zhang M; Cepeda M; Gentz R; Augustus M; Carter K C; Crocker P R
Characterization of siglec-5, a novel glycoprotein expressed on myeloid cells related to CD33.
Blood 1998;92(6):2123-32.
1998: May A P; Robinson R C; Vinson M; Crocker P R; Jones E Y
Crystal structure of the N-terminal domain of sialoadhesin in complex with 3' sialyllactose at 1.85 A resolution.
Molecular cell 1998;1(5):719-28.
1997: Mucklow S; Gordon S; Crocker P R
Characterization of the mouse sialoadhesin gene, Sn.
Mammalian genome : official journal of the International Mammalian Genome Society 1997;8(12):934-7.
1997: May A P; Robinson R C; Aplin R T; Bradfield P; Crocker P R; Jones E Y
Expression, crystallization, and preliminary X-ray analysis of a sialic acid-binding fragment of sialoadhesin in the presence and absence of ligand.
Protein science : a publication of the Protein Society 1997;6(3):717-21.
1996: Kelm S; Schauer R; Crocker P R
The Sialoadhesins--a family of sialic acid-dependent cellular recognition molecules within the immunoglobulin superfamily.
Glycoconjugate journal 1996;13(6):913-26.
1996: van der Merwe P A; Crocker P R; Vinson M; Barclay A N; Schauer R; Kelm S
Localization of the putative sialic acid-binding site on the immunoglobulin superfamily cell-surface molecule CD22.
The Journal of biological chemistry 1996;271(16):9273-80.
1996: Vinson M; van der Merwe P A; Kelm S; May A; Jones E Y; Crocker P R
Characterization of the sialic acid-binding site in sialoadhesin by site-directed mutagenesis.
The Journal of biological chemistry 1996;271(16):9267-72.
1996: Crocker P R; Kelm S; Hartnell A; Freeman S; Nath D; Vinson M; Mucklow S
Sialoadhesin and related cellular recognition molecules of the immunoglobulin superfamily.
Biochemical Society transactions 1996;24(1):150-6.
1996: Bouckson-Castaing V; Moudjou M; Ferguson D J; Mucklow S; Belkaid Y; Milon G; Crocker P R
Molecular characterisation of ninein, a new coiled-coil protein of the centrosome.
Journal of cell science 1996;109 ( Pt 1)():179-90.
1995: Nath D; van der Merwe P A; Kelm S; Bradfield P; Crocker P R
The amino-terminal immunoglobulin-like domain of sialoadhesin contains the sialic acid binding site. Comparison with CD22.
The Journal of biological chemistry 1995;270(44):26184-91.
1995: Mucklow S; Hartnell A; Mattei M G; Gordon S; Crocker P R
Sialoadhesin (Sn) maps to mouse chromosome 2 and human chromosome 20 and is not linked to the other members of the sialoadhesin family, CD22, MAG, and CD33.
Genomics 1995;28(2):344-6.
1995: Qiu L B; Dickson H; Hajibagheri N; Crocker P R
Extruded erythroblast nuclei are bound and phagocytosed by a novel macrophage receptor.
Blood 1995;85(6):1630-9.
1995: Crocker P R; Freeman S; Gordon S; Kelm S
Sialoadhesin binds preferentially to cells of the granulocytic lineage.
The Journal of clinical investigation 1995;95(2):635-43.
1994: Kelm S; Schauer R; Manuguerra J C; Gross H J; Crocker P R
Modifications of cell surface sialic acids modulate cell adhesion mediated by sialoadhesin and CD22.
Glycoconjugate journal 1994;11(6):576-85.
1994: Crocker P R; Mucklow S; Bouckson V; McWilliam A; Willis A C; Gordon S; Milon G; Kelm S; Bradfield P
Sialoadhesin, a macrophage sialic acid binding receptor for haemopoietic cells with 17 immunoglobulin-like domains.
The EMBO journal 1994;13(19):4490-503.
1992: van den Berg T K; Brevé J J; Damoiseaux J G; Döpp E A; Kelm S; Crocker P R; Dijkstra C D; Kraal G
Sialoadhesin on macrophages: its identification as a lymphocyte adhesion molecule.
The Journal of experimental medicine 1992;176(3):647-55.
1992: Perry V H; Crocker P R; Gordon S
The blood-brain barrier regulates the expression of a macrophage sialic acid-binding receptor on microglia.
Journal of cell science 1992;101 ( Pt 1)():201-7.
1992: Gordon S; Lawson L; Rabinowitz S; Crocker P R; Morris L; Perry V H
Antigen markers of macrophage differentiation in murine tissues.
Current topics in microbiology and immunology 1992;181():1-37.
1991: Crocker P R; Kelm S; Dubois C; Martin B; McWilliam A S; Shotton D M; Paulson J C; Gordon S
Purification and properties of sialoadhesin, a sialic acid-binding receptor of murine tissue macrophages.
The EMBO journal 1991;10(7):1661-9.
1991: Morris L; Crocker P R; Fraser I; Hill M; Gordon S
Expression of a divalent cation-dependent erythroblast adhesion receptor by stromal macrophages from murine bone marrow.
Journal of cell science 1991;99 ( Pt 1)():141-7.
1991: Crocker P R; Morris L; Gordon S
Adhesion receptors involved in the erythroblastic island.
Blood cells 1991;17(1):83-91; discussion 91-6.
1990: Crocker P R; Werb Z; Gordon S; Bainton D F
Ultrastructural localization of a macrophage-restricted sialic acid binding hemagglutinin, SER, in macrophage-hematopoietic cell clusters.
Blood 1990;76(6):1131-8.
1989: Crocker P R; Gordon S
Mouse macrophage hemagglutinin (sheep erythrocyte receptor) with specificity for sialylated glycoconjugates characterized by a monoclonal antibody.
The Journal of experimental medicine 1989;169(4):1333-46.
1988: Crocker P R; Hill M; Gordon S
Regulation of a murine macrophage haemagglutinin (sheep erythrocyte receptor) by a species-restricted serum factor.
Immunology 1988;65(4):515-22.
1988: Lee S H; Crocker P R; Westaby S; Key N; Mason D Y; Gordon S; Weatherall D J
Isolation and immunocytochemical characterization of human bone marrow stromal macrophages in hemopoietic clusters.
The Journal of experimental medicine 1988;168(3):1193-8.
1988: Morris L; Crocker P R; Gordon S
Murine fetal liver macrophages bind developing erythroblasts by a divalent cation-dependent hemagglutinin.
The Journal of cell biology 1988;106(3):649-56.
1988: Crocker P R; Morris L; Gordon S
Novel cell surface adhesion receptors involved in interactions between stromal macrophages and haematopoietic cells.
Journal of cell science. Supplement 1988;9():185-206.

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Paul Crocker

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