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Debra Cromley

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Daniel P O'Connell; Daniel J Rader; Jeffrey Billheimer; Debra Cromley; Daniel F LeBlanc; William W Bachovchin
Design and synthesis of boronic acid inhibitors of endothelial lipase.
sadik kassim; Hui Li; Luk Vandenberghe; Christian Hinderer; Peter Bell; Dawn Marchadier; Aisha Wilson; Debra Cromley; Valeska Redon; Hongwei Yu; James M Wilson; Daniel J Rader
Gene therapy in a humanized mouse model of familial hypercholesterolemia leads to marked regression of atherosclerosis.
Ying Liu; John S Millar; Debra Cromley; Mark Graham; Rosanne Crooke; Jeffrey T Billheimer; Daniel J Rader
Knockdown of acyl-CoA:diacylglycerol acyltransferase 2 with antisense oligonucleotide reduces VLDL TG and ApoB secretion in mice.

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All Publications

2012: Daniel P O'Connell; Daniel J Rader; Jeffrey Billheimer; Debra Cromley; Daniel F LeBlanc; William W Bachovchin
Design and synthesis of boronic acid inhibitors of endothelial lipase.
Bioorganic & medicinal chemistry letters 2012;22(3):1397-401.
2010: sadik kassim; Hui Li; Luk Vandenberghe; Christian Hinderer; Peter Bell; Dawn Marchadier; Aisha Wilson; Debra Cromley; Valeska Redon; Hongwei Yu; James M Wilson; Daniel J Rader
Gene therapy in a humanized mouse model of familial hypercholesterolemia leads to marked regression of atherosclerosis.
PloS one 2010;5(10):e13424.
2008: Ying Liu; John S Millar; Debra Cromley; Mark Graham; Rosanne Crooke; Jeffrey T Billheimer; Daniel J Rader
Knockdown of acyl-CoA:diacylglycerol acyltransferase 2 with antisense oligonucleotide reduces VLDL TG and ApoB secretion in mice.
Biochimica et biophysica acta 2008;1781(3):97-104.
2005: Michael D Orland; Kamran Anwar; Debra Cromley; Ching-Hsuen Chu; Luping Chen; Jeffrey T Billheimer; M Mahmood Hussain; Dong Cheng
Acyl coenzyme A dependent retinol esterification by acyl coenzyme A: diacylglycerol acyltransferase 1.
Biochimica et biophysica acta 2005;1737(1):76-82.
2005: John S Millar; Debra Cromley; Mary G McCoy; Daniel J Rader; Jeffrey T Billheimer
Determining hepatic triglyceride production in mice: comparison of poloxamer 407 with Triton WR-1339.
Journal of lipid research 2005;46(9):2023-8.
2005: Aaron Turkish; Annette Henneberry; Debra Cromley; Mahajabeen Padamsee; Peter Oelkers; Hisham Bazzi; Angela M Christiano; Jeffrey T Billheimer; Stephen L. Sturley
Identification of two novel human acyl-CoA wax alcohol acyltransferases: members of the diacylglycerol acyltransferase 2 (DGAT2) gene superfamily.
The Journal of biological chemistry 2005;280(15):14755-64.
2004: Bowman Miao; Susan Zondlo; Sandy Gibbs; Debra Cromley; Vinayak P Hosagrahara; Todd G Kirchgessner; Jeffrey T Billheimer; Ranjan Mukherjee
Raising HDL cholesterol without inducing hepatic steatosis and hypertriglyceridemia by a selective LXR modulator.
Journal of lipid research 2004;45(8):1410-7.
2003: Dietmar Seiffert; Andrew M Stern; William Ebling; Richard J Rossi; Yu Chen Barrett; Richard Wynn; Gregory F Hollis; Bokang He; Cathy J Kieras; Donna L Pedicord; Debra Cromley; Tsushung Hua; Robert B Stein; Robert N Daly; Anthony Sferruzza; Henry J Pieniaszek; Jeffrey T Billheimer
Prospective testing for drug-dependent antibodies reduces the incidence of thrombocytopenia observed with the small molecule glycoprotein IIb/IIIa antagonist roxifiban: implications for the etiology of thrombocytopenia.
Blood 2003;101(1):58-63.
2002: Jeffrey T Billheimer; ira dicker; Richard Wynn; Jodi D Bradley; Debra Cromley; Helen E Godonis; Lisa C Grimminger; Bokang He; Cathy J Kieras; Donna L Pedicord; Susan M Spitz; Beth E Thomas; Nina I Zolotarjova; Mary A Gorko; Gregory F Hollis; Robert N Daly; Andrew M Stern; Dietmar Seiffert
Evidence that thrombocytopenia observed in humans treated with orally bioavailable glycoprotein IIb/IIIa antagonists is immune mediated.
Blood 2002;99(10):3540-6.
2002: Peter Oelkers; Debra Cromley; Mahajabeen Padamsee; Jeffrey T Billheimer; Stephen L. Sturley
The DGA1 gene determines a second triglyceride synthetic pathway in yeast.
The Journal of biological chemistry 2002;277(11):8877-81.
2001: Dong Cheng; Rupalie Lalana Meegalla; Bokang He; Debra Cromley; Jeffrey T Billheimer; Peter Young
Human acyl-CoA:diacylglycerol acyltransferase is a tetrameric protein.
The Biochemical journal 2001;359(Pt 3):707-14.
2001: Z Guo; Debra Cromley; Jeffrey T Billheimer; Stephen L. Sturley
Identification of potential substrate-binding sites in yeast and human acyl-CoA sterol acyltransferases by mutagenesis of conserved sequences.
Journal of lipid research 2001;42(8):1282-91.
2000: Peter Oelkers; Arthur H Tinkelenberg; Naz Erdeniz; Debra Cromley; Jeffrey T Billheimer; Stephen L. Sturley
A lecithin cholesterol acyltransferase-like gene mediates diacylglycerol esterification in yeast.
The Journal of biological chemistry 2000;275(21):15609-12.
1998: Peter Oelkers; A Behari; Debra Cromley; Jeffrey T Billheimer; Stephen L. Sturley
Characterization of two human genes encoding acyl coenzyme A:cholesterol acyltransferase-related enzymes.
The Journal of biological chemistry 1998;273(41):26765-71.
1997: Hong Yang; Debra Cromley; H Wang; Jeffrey T Billheimer; Stephen L. Sturley
Functional expression of a cDNA to human acyl-coenzyme A:cholesterol acyltransferase in yeast. Species-dependent substrate specificity and inhibitor sensitivity.
The Journal of biological chemistry 1997;272(7):3980-5.
1995: T P Maduskuie; Richard G Wilde; J T Billheimer; Debra Cromley; S Germain; P J Gillies; C Anne Higley; A L Johnson; P Pennev; E J Shimshick
Design, synthesis, and structure--activity relationship studies for a new imidazole series of J774 macrophage specific acyl-CoA:cholesterol acyltransferase (ACAT) inhibitors.
Journal of medicinal chemistry 1995;38(7):1067-83.
1990: J T Billheimer; Debra Cromley; E S Kempner
The functional size of acyl-coenzyme A (CoA):cholesterol acyltransferase and acyl-CoA hydrolase as determined by radiation inactivation.
The Journal of biological chemistry 1990;265(15):8632-5.