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Stanley Crooke

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Timothy A Vickers; Walt F Lima; Hongjiang Wu; Josh G Nichols; Peter Linsley; Stanley T Crooke
Off-target and a portion of target-specific siRNA mediated mRNA degradation is Ago2 'Slicer' independent and can be mediated by Ago1.
Walt F Lima; Hongjiang Wu; Josh G Nichols; Hong Sun; Heather M Murray; Stanley T Crooke
Binding and cleavage specificities of human Argonaute2.
Walt F Lima; Heather Murray; Josh G Nichols; Hongjiang Wu; Hong Sun; Thazha P Prakash; Andres R Berdeja; Hans J Gaus; Stanley T Crooke
Human Dicer binds short single-strand and double-strand RNA with high affinity and interacts with different regions of the nucleic acids.

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2009: Timothy A Vickers; Walt F Lima; Hongjiang Wu; Josh G Nichols; Peter Linsley; Stanley T Crooke
Off-target and a portion of target-specific siRNA mediated mRNA degradation is Ago2 'Slicer' independent and can be mediated by Ago1.
Nucleic acids research 2009;37(20):6927-41.
2009: Walt F Lima; Hongjiang Wu; Josh G Nichols; Hong Sun; Heather M Murray; Stanley T Crooke
Binding and cleavage specificities of human Argonaute2.
The Journal of biological chemistry 2009;284(38):26017-28.
2009: Walt F Lima; Heather Murray; Josh G Nichols; Hongjiang Wu; Hong Sun; Thazha P Prakash; Andres R Berdeja; Hans J Gaus; Stanley T Crooke
Human Dicer binds short single-strand and double-strand RNA with high affinity and interacts with different regions of the nucleic acids.
The Journal of biological chemistry 2009;284(4):2535-48.
2007: Mark J Graham; Kristina M Lemonidis; Charles P Whipple; Amuthakannan Subramaniam; Brett P Monia; Stanley T Crooke; Rosanne M Crooke
Antisense inhibition of proprotein convertase subtilisin/kexin type 9 reduces serum LDL in hyperlipidemic mice.
Journal of lipid research 2007;48(4):763-7.
2007: Timothy A Vickers; Walt F Lima; Josh G Nichols; Stanley T Crooke
Reduced levels of Ago2 expression result in increased siRNA competition in mammalian cells.
Nucleic acids research 2007;35(19):6598-610.
2007: Walt F Lima; John B Rose; Josh G Nichols; Hongjiang Wu; Michael T Migawa; Tadeusz K Wyrzykiewicz; Andrew Siwkowski; Stanley T Crooke
Human RNase H1 discriminates between subtle variations in the structure of the heteroduplex substrate.
Molecular pharmacology 2007;71(1):83-91.
2007: Walt F Lima; John B Rose; Josh G Nichols; Hongjiang Wu; Michael T Migawa; Tadeusz K Wyrzykiewicz; Guillermo Vasquez; Eric E Swayze; Stanley T Crooke
The positional influence of the helical geometry of the heteroduplex substrate on human RNase H1 catalysis.
Molecular pharmacology 2007;71(1):73-82.
2005: David J Ecker; Rangarajan Sampath; Lawrence B Blyn; Mark W Eshoo; Cristina Ivy; Joseph A Ecker; Brian Libby; Vivek Samant; Kristin A Sannes-Lowery; Rachael E Melton; Kevin Russell; Nikki Freed; Christopher P Barrozo; Jianguo Wu; Karl Rudnick; Anjali Desai; Emily Moradi; Duane J Knize; David W Robbins; James C Hannis; Patina Harrell; Christian Massire; Thomas A Hall; Yun Jiang; Ray Ranken; Jared J Drader; Neill White; John A McNeil; Stanley T Crooke; Steven A Hofstadler
Rapid identification and strain-typing of respiratory pathogens for epidemic surveillance.
Proceedings of the National Academy of Sciences of the United States of America 2005;102(22):8012-7.
2005: Rangarajan Sampath; Steven A Hofstadler; Lawrence B Blyn; Mark W Eshoo; Thomas A Hall; Christian Massire; Harold M Levene; James C Hannis; Patina Harrell; Benjamin Neuman; Michael J Buchmeier; Yun Jiang; Ray Ranken; Jared J Drader; Vivek Samant; Richard H Griffey; John A McNeil; Stanley T Crooke; David J Ecker
Rapid identification of emerging pathogens: coronavirus.
Emerging infectious diseases 2005;11(3):373-9.
2004: Walt F Lima; Josh G Nichols; Hongjiang Wu; Thazha P Prakash; Michael T Migawa; Tadeusz K Wyrzykiewicz; Balkrishen Bhat; Stanley T Crooke
Structural requirements at the catalytic site of the heteroduplex substrate for human RNase H1 catalysis.
The Journal of biological chemistry 2004;279(35):36317-26.
2004: Stanley T Crooke
Antisense strategies.
Current molecular medicine 2004;4(5):465-87.
2004: Hongjiang Wu; Walt F Lima; Hong Zhang; Amy Fan; Hong Sun; Stanley T Crooke
Determination of the role of the human RNase H1 in the pharmacology of DNA-like antisense drugs.
The Journal of biological chemistry 2004;279(17):17181-9.
2004: Stanley T Crooke
Progress in antisense technology.
Annual review of medicine 2004;55():61-95.
2003: Walt F Lima; Hongjiang Wu; Josh G Nichols; Thazha P Prakash; Vasulinga T Ravikumar; Stanley T Crooke
Human RNase H1 uses one tryptophan and two lysines to position the enzyme at the 3'-DNA/5'-RNA terminus of the heteroduplex substrate.
The Journal of biological chemistry 2003;278(50):49860-7.
2003: Walt F Lima; Hongjiang Wu; Josh G Nichols; Sherilynn M Manalili; Jared J Drader; Steven A Hofstadler; Stanley T Crooke
Human RNase H1 activity is regulated by a unique redox switch formed between adjacent cysteines.
The Journal of biological chemistry 2003;278(17):14906-12.
2003: Timothy A Vickers; Seongjoon Koo; C Frank Bennett; Stanley T Crooke; Nicholas Dean; Brenda F Baker
Efficient reduction of target RNAs by small interfering RNA and RNase H-dependent antisense agents. A comparative analysis.
The Journal of biological chemistry 2003;278(9):7108-18.
2001: Mark J Graham; Stanley T Crooke; Kristina M Lemonidis; H J Gaus; Mike V Templin; Rosanne M Crooke
Hepatic distribution of a phosphorothioate oligodeoxynucleotide within rodents following intravenous administration.
Biochemical pharmacology 2001;62(3):297-306.
2001: Hongjiang Wu; Walt F Lima; Stanley T Crooke
Investigating the structure of human RNase H1 by site-directed mutagenesis.
The Journal of biological chemistry 2001;276(26):23547-53.
2001: Walt F Lima; Stanley T Crooke
Preparation and use of ZFY-6 zinc finger ribonuclease.
Methods in enzymology 2001;341():490-500.
2001: Walt F Lima; Hongjiang Wu; Stanley T Crooke
Human RNases H.
Methods in enzymology 2001;341():430-40.
2000: L Miraglia; A T Watt; Mark J Graham; Stanley T Crooke
Variations in mRNA content have no effect on the potency of antisense oligonucleotides.
Antisense & nucleic acid drug development 2000;10(6):453-61.
2000: Stanley T Crooke
Evaluating the mechanism of action of antiproliferative antisense drugs.
Antisense & nucleic acid drug development 2000;10(2):123-6; discussion 127.
1999: H Wu; Walt F Lima; Stanley T Crooke
Properties of cloned and expressed human RNase H1.
The Journal of biological chemistry 1999;274(40):28270-8.
1999: Richard H Griffey; Steven A Hofstadler; Kristin A Sannes-Lowery; David J Ecker; Stanley T Crooke
Determinants of aminoglycoside-binding specificity for rRNA by using mass spectrometry.
Proceedings of the National Academy of Sciences of the United States of America 1999;96(18):10129-33.
1999: Walt F Lima; Stanley T Crooke
Highly efficient endonucleolytic cleavage of RNA by a Cys(2)His(2) zinc-finger peptide.
Proceedings of the National Academy of Sciences of the United States of America 1999;96(18):10010-5.
1999: Steven A Hofstadler; Kristin A Sannes-Lowery; Stanley T Crooke; David J Ecker; H Sasmor; S Manalili; Richard H Griffey
Multiplexed screening of neutral mass-tagged RNA targets against ligand libraries with electrospray ionization FTICR MS: a paradigm for high-throughput affinity screening.
Analytical chemistry 1999;71(16):3436-40.
1998: L Levesque; Stanley T Crooke
Depletion of protein kinase C-alpha by antisense oligonucleotides alters beta-adrenergic function and reverses the phorbol ester-induced reduction of isoproterenol-induced adenosine 3'-5'-cyclic monophosphate accumulation in murine Swiss 3T3 fibroblasts.
The Journal of pharmacology and experimental therapeutics 1998;287(1):425-34.
1998: Mark J Graham; Stanley T Crooke; David K Monteith; Scott R Cooper; Kristina M Lemonidis; Kim Stecker; M J Martin; Rosanne M Crooke
In vivo distribution and metabolism of a phosphorothioate oligonucleotide within rat liver after intravenous administration.
The Journal of pharmacology and experimental therapeutics 1998;286(1):447-58.
1998: Stanley T Crooke
Optimizing the impact of genomics on drug discovery and development.
Nature biotechnology 1998;16 Suppl():29-30.
1998: Stanley T Crooke
Molecular mechanisms of antisense drugs: RNase H.
Antisense & nucleic acid drug development 1998;8(2):133-4.
1998: Stanley T Crooke
An overview of progress in antisense therapeutics.
Antisense & nucleic acid drug development 1998;8(2):115-22.
1998: H Wu; Walt F Lima; Stanley T Crooke
Molecular cloning and expression of cDNA for human RNase H.
Antisense & nucleic acid drug development 1998;8(1):53-61.
1998: H Wu; A R MacLeod; Walt F Lima; Stanley T Crooke
Identification and partial purification of human double strand RNase activity. A novel terminating mechanism for oligoribonucleotide antisense drugs.
The Journal of biological chemistry 1998;273(5):2532-42.
1998: Stanley T Crooke
Antisense therapeutics.
Biotechnology & genetic engineering reviews 1998;15():121-57.
1997: Walt F Lima; Stanley T Crooke
Cleavage of single strand RNA adjacent to RNA-DNA duplex regions by Escherichia coli RNase H1.
The Journal of biological chemistry 1997;272(44):27513-6.
1997: Walt F Lima; V Mohan; Stanley T Crooke
The influence of antisense oligonucleotide-induced RNA structure on Escherichia coli RNase H1 activity.
The Journal of biological chemistry 1997;272(29):18191-9.
1997: David K Monteith; Scott P Henry; R B Howard; S Flournoy; Arthur A Levin; C Frank Bennett; Stanley T Crooke
Immune stimulation--a class effect of phosphorothioate oligodeoxynucleotides in rodents.
Anti-cancer drug design 1997;12(5):421-32.
1997: Stanley T Crooke
Oligonucleotide analogs might be designed to bind to m-RNA.
Anti-cancer drug design 1997;12(5):311-3.
1997: L Levesque; Nicholas Dean; H Sasmor; Stanley T Crooke
Antisense oligonucleotides targeting human protein kinase C-alpha inhibit phorbol ester-induced reduction of bradykinin-evoked calcium mobilization in A549 cells.
Molecular pharmacology 1997;51(2):209-16.
1997: Walt F Lima; Stanley T Crooke
Binding affinity and specificity of Escherichia coli RNase H1: impact on the kinetics of catalysis of antisense oligonucleotide-RNA hybrids.
Biochemistry 1997;36(2):390-8.
1997: Stanley T Crooke
Advances in understanding the pharmacological properties of antisense oligonucleotides.
Advances in pharmacology (San Diego, Calif.) 1997;40():1-49.
1997: Scott P Henry; J E Zuckerman; J Rojko; William Hall; R J Harman; D Kitchen; Stanley T Crooke
Toxicological properties of several novel oligonucleotide analogs in mice.
Anti-cancer drug design 1997;12(1):1-14.
1996: R M Crooke; Stanley T Crooke; M J Graham; M E Cooke
Effect of antisense oligonucleotides on cytokine release from human keratinocytes in an in vitro model of skin.
Toxicology and applied pharmacology 1996;140(1):85-93.
1996: Stanley T Crooke; M J Graham; J E Zuckerman; D Brooks; B S Conklin; Lendell L Cummins; M J Greig; C J Guinosso; D Kornbrust; Muthiah Manoharan; Henri Sasmor; T Schleich; K L Tivel; Richard H Griffey
Pharmacokinetic properties of several novel oligonucleotide analogs in mice.
The Journal of pharmacology and experimental therapeutics 1996;277(2):923-37.
1996: Stanley T Crooke
The future of sequence-specific transcriptional inhibition.
Cancer investigation 1996;14(1):89-90.
1995: Stanley T Crooke; K M Lemonidis; L Neilson; Richard H Griffey; Elena A Lesnik; Brett P Monia
Kinetic characteristics of Escherichia coli RNase H1: cleavage of various antisense oligonucleotide-RNA duplexes.
The Biochemical journal 1995;312 ( Pt 2)():599-608.
1995: R M Crooke; M J Graham; M E Cooke; Stanley T Crooke
In vitro pharmacokinetics of phosphorothioate antisense oligonucleotides.
The Journal of pharmacology and experimental therapeutics 1995;275(1):462-73.
1995: Stanley T Crooke
Progress in antisense therapeutics.
Hematologic pathology 1995;9(2):59-72.
1994: PA Cossum; Loanne Truong; S R Owens; P M Markham; J P Shea; Stanley T Crooke
Pharmacokinetics of a 14C-labeled phosphorothioate oligonucleotide, ISIS 2105, after intradermal administration to rats.
The Journal of pharmacology and experimental therapeutics 1994;269(1):89-94.
1993: PA Cossum; Henri Sasmor; D Dellinger; Loanne Truong; Lendell L Cummins; S R Owens; P M Markham; J P Shea; Stanley T Crooke
Disposition of the 14C-labeled phosphorothioate oligonucleotide ISIS 2105 after intravenous administration to rats.
The Journal of pharmacology and experimental therapeutics 1993;267(3):1181-90.