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Peter Crooks

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TOP 3
Narsimha Reddy Penthala; Purushothama Rao Ponugoti; Agripina G Deaciuc; Linda P Dwoskin; Justin R Nickell; Peter A Crooks
Pyrrolidine analogs of GZ-793A: Synthesis and evaluation as inhibitors of the vesicular monoamine transporter-2 (VMAT2).
Amudhan Venkateswaran; Alexandra J Walsh; Melissa Skala; Peter A Crooks; Michael L Freeman; David B Friedman; Girish Rachakonda; Soumya Sasi; Konjeti R Sekhar
The novel antiangiogenic VJ115 inhibits the NADH oxidase ENOX1 and cytoskeleton-remodeling proteins.
Vijayakumar N Sonar; Sean Parkin; Peter A Crooks
(E)-3-(Benzo[b]thiophen-2-yl)-2-(3,4,5-trimethoxyphenyl)acrylonitrile and (Z)-3-(benzo[b]thiophen-2-yl)-2-(3,4-dimethoxyphenyl)acrylonitrile. Corrigendum.

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2013: Narsimha Reddy Penthala; Purushothama Rao Ponugoti; Agripina G Deaciuc; Linda P Dwoskin; Justin R Nickell; Peter A Crooks
Pyrrolidine analogs of GZ-793A: Synthesis and evaluation as inhibitors of the vesicular monoamine transporter-2 (VMAT2).
Bioorganic & medicinal chemistry letters 2013;23(11):3342-5.
2013: Amudhan Venkateswaran; Alexandra J Walsh; Melissa Skala; Peter A Crooks; Michael L Freeman; David B Friedman; Girish Rachakonda; Soumya Sasi; Konjeti R Sekhar
The novel antiangiogenic VJ115 inhibits the NADH oxidase ENOX1 and cytoskeleton-remodeling proteins.
Investigational new drugs 2013;31(3):535-44.
2013: Vijayakumar N Sonar; Sean Parkin; Peter A Crooks
(E)-3-(Benzo[b]thiophen-2-yl)-2-(3,4,5-trimethoxyphenyl)acrylonitrile and (Z)-3-(benzo[b]thiophen-2-yl)-2-(3,4-dimethoxyphenyl)acrylonitrile. Corrigendum.
Acta crystallographica. Section C, Crystal structure communications 2013;69(Pt 4):454.
2013: Nikhil Reddy Madadi; Narsimha Reddy Penthala; Paul L Prather; Lisa K Brents; Benjamin M Ford; Peter A Crooks
Evaluation of (Z)-2-((1-benzyl-1H-indol-3-yl)methylene)-quinuclidin-3-one analogues as novel, high affinity ligands for CB1 and CB2 cannabinoid receptors.
Bioorganic & medicinal chemistry letters 2013;23(7):2019-21.
2013: Joshua R Ring; Fang Zheng; Aaron J Haubner; John M Littleton; Peter A Crooks
Improving the inhibitory activity of arylidenaminoguanidine compounds at the N-methyl-D-aspartate receptor complex from a recursive computational-experimental structure-activity relationship study.
Bioorganic & medicinal chemistry 2013;21(7):1764-74.
2013: Narsimha Reddy Penthala; Purushothama Rao Ponugoti; Vinod Kasam; Peter A Crooks
5-((1-Aroyl-1H-indol-3-yl)methylene)-2-thioxodihydropyrimidine-4,6(1H,5H)-diones as potential anticancer agents with anti-inflammatory properties.
Bioorganic & medicinal chemistry letters 2013;23(5):1442-6.
2013: Narsimha Reddy Penthala; Peter A Crooks
rac-N-Benzyl-isatincreatinine (unknown solvate).
Acta crystallographica. Section E, Structure reports online 2013;69(Pt 2):o290-1.
2013: Narsimha Reddy Penthala; Peter A Crooks
rac-5-Bromo-N-benzyl-isatincreatinine ethanol monosolvate.
Acta crystallographica. Section E, Structure reports online 2013;69(Pt 2):o288-9.
2012: Narsimha Reddy Penthala; Purushotham Rao Ponugoti; Sean Parkin; Peter A Crooks
rac-(Z)-Methyl 1-benzyl-3-[(3-hy-droxy-quinuclidin-2-yl-idene)meth-yl]-1H-indole-6-carboxyl-ate.
Acta crystallographica. Section E, Structure reports online 2012;68(Pt 11):o3111.
2012: Vijayakumar N Sonar; Sean Parkin; Peter A Crooks
Oxycodone N-oxide.
Acta crystallographica. Section C, Crystal structure communications 2012;68(Pt 11):o436-8.
2012: Kristin M Alvers; Joshua S Beckmann; Peter A Crooks; Linda P Dwoskin; Guangrong Zheng; Michael T Bardo
The effect of VMAT2 inhibitor GZ-793A on the reinstatement of methamphetamine-seeking in rats.
Psychopharmacology 2012;224(2):255-62.
2012: Vijayakumar N Sonar; Sean Parkin; Peter A Crooks
The effect of hydrogen bonding on the conformations of 2-(1H-indol-3-yl)-2-oxoacetamide and 2-(1H-indol-3-yl)-N,N-dimethyl-2-oxoacetamide.
Acta crystallographica. Section C, Crystal structure communications 2012;68(Pt 10):o405-7.
2012: Elzbieta P Wala; J Michael McIntosh; Peter A Crooks; Joseph R Holtman
Novel small molecule α9α10 nicotinic receptor antagonist prevents and reverses chemotherapy-evoked neuropathic pain in rats.
Anesthesia and analgesia 2012;115(3):713-20.
2012: Joshua S Beckmann; Peter A Crooks; Emily D Denehy; Linda P Dwoskin; Guangrong Zheng; Michael T Bardo
The effect of a novel VMAT2 inhibitor, GZ-793A, on methamphetamine reward in rats.
Psychopharmacology 2012;220(2):395-403.
2011: Konjeti R Sekhar; Robert P Van Der Waal; Amudhan Venkateswaran; Peter A Crooks; Ling Geng; William Hayes McDonald; Girish Rachakonda; Penthala Narsimha Reddy; Yerramreddy Thirupathi Reddy; Joseph L Roti Roti; Kenneth J Salleng; Soumya Sasi; Michael L Freeman
The novel chemical entity YTR107 inhibits recruitment of nucleophosmin to sites of DNA damage, suppressing repair of DNA double-strand breaks and enhancing radiosensitization.
Clinical cancer research : an official journal of the American Association for Cancer Research 2011;17(20):6490-9.
2011: David B Horton; Kiran B Siripurapu; Guangrong Zheng; Peter A Crooks; Linda P Dwoskin
Novel N-1,2-dihydroxypropyl analogs of lobelane inhibit vesicular monoamine transporter-2 function and methamphetamine-evoked dopamine release.
The Journal of pharmacology and experimental therapeutics 2011;339(1):286-97.
2011: Shama Nasim; Monica L Guzman; Craig T Jordan; Peter A Crooks
Discovery of 1,2,4-thiadiazolidine-3,5-dione analogs that exhibit unusual and selective rapid cell death kinetics against acute myelogenous leukemia cells in culture.
Bioorganic & medicinal chemistry letters 2011;21(16):4879-83.
2011: Marharyta Pivavarchyk; Andrew M Smith; Zhenfa Zhang; Dejun Zhou; Xu Wang; Naoki Toyooka; Hiroshi Tsuneki; Toshiyasu Sasaoka; J Michael McIntosh; Peter A Crooks; Linda P Dwoskin
Indolizidine (-)-235B' and related structural analogs: discovery of nicotinic receptor antagonists that inhibit nicotine-evoked [3H]dopamine release.
European journal of pharmacology 2011;658(2-3):132-9.
2011: Thomas E Wooters; Andrew M Smith; Marharyta Pivavarchyk; Kiran B Siripurapu; J Michael McIntosh; Zhenfa Zhang; Peter A Crooks; Michael T Bardo; Linda P Dwoskin
bPiDI: a novel selective α6β2* nicotinic receptor antagonist and preclinical candidate treatment for nicotine abuse.
British journal of pharmacology 2011;163(2):346-57.
2011: Guangrong Zheng; Zhenfa Zhang; Cheryl Dowell; Elzbieta Wala; Linda P Dwoskin; Joseph R Holtman; J Michael McIntosh; Peter A Crooks
Discovery of non-peptide, small molecule antagonists of α9α10 nicotinic acetylcholine receptors as novel analgesics for the treatment of neuropathic and tonic inflammatory pain.
Bioorganic & medicinal chemistry letters 2011;21(8):2476-9.
2011: Narsimha Reddy Penthala; Thirupathi Reddy Yerramreddy; Peter A Crooks
Synthesis and in vitro screening of novel N-benzyl aplysinopsin analogs as potential anticancer agents.
Bioorganic & medicinal chemistry letters 2011;21(5):1411-3.
2011: Abeer M Al-Ghananeem; Ahmad H Malkawi; Peter A Crooks
Bioavailability of Δ⁹-tetrahydrocannabinol following intranasal administration of a mucoadhesive gel spray delivery system in conscious rabbits.
Drug development and industrial pharmacy 2011;37(3):329-34.
2011: David B Horton; Kiran B Siripurapu; Seth D Norrholm; John P Culver; Marhaba Hojahmat; Joshua S Beckmann; Steven B Harrod; Agripina G Deaciuc; Michael T Bardo; Peter A Crooks; Linda P Dwoskin
meso-Transdiene analogs inhibit vesicular monoamine transporter-2 function and methamphetamine-evoked dopamine release.
The Journal of pharmacology and experimental therapeutics 2011;336(3):940-51.
2011: Justin R Nickell; Guangrong Zheng; Agripina G Deaciuc; Peter A Crooks; Linda P Dwoskin
Phenyl ring-substituted lobelane analogs: inhibition of [³H]dopamine uptake at the vesicular monoamine transporter-2.
The Journal of pharmacology and experimental therapeutics 2011;336(3):724-33.
2011: Shama Nasim; Shanshan Pei; Fred K Hagen; Craig T Jordan; Peter A Crooks
Melampomagnolide B: a new antileukemic sesquiterpene.
Bioorganic & medicinal chemistry 2011;19(4):1515-9.
2011: Zhenfa Zhang; Guangrong Zheng; Marharyta Pivavarchyk; Agripina G Deaciuc; Linda P Dwoskin; Peter A Crooks
Novel bis-, tris-, and tetrakis-tertiary amino analogs as antagonists at neuronal nicotinic receptors that mediate nicotine-evoked dopamine release.
Bioorganic & medicinal chemistry letters 2011;21(1):88-91.
2011: Peter A Crooks; Guangrong Zheng; Ashish P Vartak; John P Culver; Fang Zheng; David B Horton; Linda P Dwoskin
Design, synthesis and interaction at the vesicular monoamine transporter-2 of lobeline analogs: potential pharmacotherapies for the treatment of psychostimulant abuse.
Current topics in medicinal chemistry 2011;11(9):1103-27.
2010: Shama Nasim; Ashish P Vartak; William M Pierce; K Grant Taylor; Ned Smith; Peter A Crooks
3-O-phosphate ester conjugates of 17-β-O-{1-[2-carboxy-(2-hydroxy-4-methoxy-3-carboxamido)anilido]ethyl}1,3,5(10)-estratriene as novel bone-targeting agents.
Bioorganic & medicinal chemistry letters 2010;20(24):7450-3.
2010: Amudhan Venkateswaran; Y Thirupathi Reddy; Vijayakumar N Sonar; Venkatraj Muthusamy; Peter A Crooks; Michael L Freeman; SEKHAR KONJETI
Antiangiogenic properties of substituted (Z)-(±)-2-(N-benzylindol-3-ylmethylene)quinuclidin-3-ol/one analogs and their derivatives.
Bioorganic & medicinal chemistry letters 2010;20(24):7323-6.
2010: Joseph R Holtman; Peter A Crooks; Jaime Johnson-Hardy; Elzbieta P Wala
Antinociceptive effects and toxicity of morphine-6-O-sulfate sodium salt in rat models of pain.
European journal of pharmacology 2010;648(1-3):87-94.
2010: Joshua S Beckmann; Kiran B Siripurapu; Justin R Nickell; David B Horton; Emily D Denehy; Ashish Vartak; Peter A Crooks; Linda P Dwoskin; Michael T Bardo
The novel pyrrolidine nor-lobelane analog UKCP-110 [cis-2,5-di-(2-phenethyl)-pyrrolidine hydrochloride] inhibits VMAT2 function, methamphetamine-evoked dopamine release, and methamphetamine self-administration in rats.
The Journal of pharmacology and experimental therapeutics 2010;335(3):841-51.
2010: Mikolaj Milewski; Thirupathi Reddy Yerramreddy; Priyanka Ghosh; Peter A Crooks; Audra Stinchcomb
In vitro permeation of a pegylated naltrexone prodrug across microneedle-treated skin.
Journal of controlled release : official journal of the Controlled Release Society 2010;146(1):37-44.
2010: Narsimha Reddy Penthala; Thirupathi Reddy Yerramreddy; Nikhil Reddy Madadi; Peter A Crooks
Synthesis and in vitro evaluation of N-alkyl-3-hydroxy-3-(2-imino-3-methyl-5-oxoimidazolidin-4-yl)indolin-2-one analogs as potential anticancer agents.
Bioorganic & medicinal chemistry letters 2010;20(15):4468-71.
2010: Andrew M Smith; Marharyta Pivavarchyk; Thomas E Wooters; Zhenfa Zhang; Guangrong Zheng; J Michael McIntosh; Peter A Crooks; Michael T Bardo; Linda P Dwoskin
Repeated nicotine administration robustly increases bPiDDB inhibitory potency at alpha6beta2-containing nicotinic receptors mediating nicotine-evoked dopamine release.
Biochemical pharmacology 2010;80(3):402-9.
2010: Stan L Banks; Raghotham R Pinninti; Harvinder S Gill; Kalpana S Paudel; Peter A Crooks; Nicole K Brogden; Mark R Prausnitz; Audra Stinchcomb
Transdermal delivery of naltrexol and skin permeability lifetime after microneedle treatment in hairless guinea pigs.
Journal of pharmaceutical sciences 2010;99(7):3072-80.
2010: Ashish P Vartak; A Gabriela Deaciuc; Linda P Dwoskin; Peter A Crooks
Quinlobelane: a water-soluble lobelane analogue and inhibitor of VMAT2.
Bioorganic & medicinal chemistry letters 2010;20(12):3584-7.
2010: Jyothi Matharu; Jun Oki; David R Worthen; Quentin R Smith; Peter A Crooks
Regiospecific and conformationally restrained analogs of melphalan and DL-2-NAM-7 and their affinities for the large neutral amino acid transporter (system LAT1) of the blood-brain barrier.
Bioorganic & medicinal chemistry letters 2010;20(12):3688-91.
2010: Guangrong Zheng; Zhenfa Zhang; Paul R Lockman; Werner J Geldenhuys; David D Allen; Linda P Dwoskin; Peter A Crooks
Bis-azaaromatic quaternary ammonium salts as ligands for the blood-brain barrier choline transporter.
Bioorganic & medicinal chemistry letters 2010;20(11):3208-10.
2010: Thirupathi Reddy Yerramreddy; Mikolaj Milewski; Narsimha Reddy Penthala; Audra Stinchcomb; Peter A Crooks
Novel 3-O-pegylated carboxylate and 3-O-pegylated carbamate prodrugs of naltrexone for microneedle-enhanced transdermal delivery.
Bioorganic & medicinal chemistry letters 2010;20(11):3280-3.
2010: Y Thirupathi Reddy; P Narsimha Reddy; Srinivas Koduru; Chendil Damodaran; Peter A Crooks
Aplysinopsin analogs: Synthesis and anti-proliferative activity of substituted (Z)-5-(N-benzylindol-3-ylmethylene)imidazolidine-2,4-diones.
Bioorganic & medicinal chemistry 2010;18(10):3570-4.
2010: Yulan Sun; Daret K St Clair; Yong Xu; Peter A Crooks; William St Clair
A NADPH oxidase-dependent redox signaling pathway mediates the selective radiosensitization effect of parthenolide in prostate cancer cells.
Cancer research 2010;70(7):2880-90.
2010: Zhenfa Zhang; Marharyta Pivavarchyk; Karunai Leela Subramanian; Agripina G Deaciuc; Linda P Dwoskin; Peter A Crooks
Novel bis-2,2,6,6-tetramethylpiperidine (bis-TMP) and bis-mecamylamine antagonists at neuronal nicotinic receptors mediating nicotine-evoked dopamine release.
Bioorganic & medicinal chemistry letters 2010;20(4):1420-3.
2010: Justin R Nickell; Sairam Krishnamurthy; Seth D Norrholm; Gabriela Deaciuc; Kiran B Siripurapu; Guangrong Zheng; Peter A Crooks; Linda P Dwoskin
Lobelane inhibits methamphetamine-evoked dopamine release via inhibition of the vesicular monoamine transporter-2.
The Journal of pharmacology and experimental therapeutics 2010;332(2):612-21.
2010: Marhaba Hojahmat; David B Horton; Seth D Norrholm; Dennis K Miller; Vladimir P Grinevich; Agripina G Deaciuc; Linda P Dwoskin; Peter A Crooks
Lobeline esters as novel ligands for neuronal nicotinic acetylcholine receptors and neurotransmitter transporters.
Bioorganic & medicinal chemistry 2010;18(2):640-9.
2010: Narsimha Reddy Penthala; Thirupathi Reddy Yerramreddy; Peter A Crooks
Microwave assisted synthesis and in vitro cytotoxicities of substituted (Z)-2-amino-5-(1-benzyl-1H-indol-3-yl)methylene-1-methyl-1H-imidazol-4(5H)-ones against human tumor cell lines.
Bioorganic & medicinal chemistry letters 2010;20(2):591-3.
2010: Y Thirupathi Reddy; SEKHAR KONJETI; Nidhish Sasi; P Narsimha Reddy; Michael L Freeman; Peter A Crooks
Novel substituted (Z)-5-((N-benzyl-1H-indol-3-yl)methylene)imidazolidine-2,4-diones and 5-((N-benzyl-1H-indol-3-yl)methylene)pyrimidine-2,4,6(1H,3H,5H)-triones as potent radio-sensitizing agents.
Bioorganic & medicinal chemistry letters 2010;20(2):600-2.
2010: Joseph R Holtman; Peter A Crooks; Jaime K Johnson-Hardy; Elzbieta P Wala
The analgesic and toxic effects of nornicotine enantiomers alone and in interaction with morphine in rodent models of acute and persistent pain.
Pharmacology, biochemistry, and behavior 2010;94(3):352-62.
2009: Ashish P Vartak; Justin R Nickell; Jaturaporn Chagkutip; Linda P Dwoskin; Peter A Crooks
Pyrrolidine analogues of lobelane: relationship of affinity for the dihydrotetrabenazine binding site with function of the vesicular monoamine transporter 2 (VMAT2).
Journal of medicinal chemistry 2009;52(23):7878-82.
2009: Sundar Neelakantan; Iwan Surjawan; Huseyin Karacelik; Clair L Hicks; Peter A Crooks
Synthesis of novel isoluminol probes and their use in rapid bacterial assays.
Bioorganic & medicinal chemistry letters 2009;19(19):5722-6.
2009: Andrew M Smith; Gurpreet K Dhawan; Zhenfa Zhang; Kiran B Siripurapu; Peter A Crooks; Linda P Dwoskin
The novel nicotinic receptor antagonist, N,N'-dodecane-1,12-diyl-bis-3-picolinium dibromide (bPiDDB), inhibits nicotine-evoked [(3)H]norepinephrine overflow from rat hippocampal slices.
Biochemical pharmacology 2009;78(7):889-97.
2009: Linda P Dwoskin; Andrew M Smith; Thomas E Wooters; Zhenfa Zhang; Peter A Crooks; Michael T Bardo
Nicotinic receptor-based therapeutics and candidates for smoking cessation.
Biochemical pharmacology 2009;78(7):732-43.
2009: David R Worthen; Aimee K Bence; James P Stables; Peter A Crooks
In vivo evaluation of diaminodiphenyls: anticonvulsant agents with minimal acute neurotoxicity.
Bioorganic & medicinal chemistry letters 2009;19(17):5012-5.
2009: Ling Geng; Girish Rachakonda; D James Morré; Dorothy M Morré; Peter A Crooks; Vijayakumar N Sonar; Joseph L Roti Roti; Buck E Rogers; Suellen Greco; Fei Ye; Kenneth J Salleng; Soumya Sasi; Michael L Freeman; SEKHAR KONJETI
Indolyl-quinuclidinols inhibit ENOX activity and endothelial cell morphogenesis while enhancing radiation-mediated control of tumor vasculature.
FASEB journal : official publication of the Federation of American Societies for Experimental Biology 2009;23(9):2986-95.
2009: Guangrong Zheng; Linda P Dwoskin; Agripina G Deaciuc; Peter A Crooks
Stereocontrolled synthesis and pharmacological evaluation of cis-2,6-diphenethyl-1-azabicyclo[2.2.2]octanes as lobelane analogues.
The Journal of organic chemistry 2009;74(16):6072-6.
2009: Sundar Neelakantan; Shama Nasim; Monica L Guzman; Craig T Jordan; Peter A Crooks
Aminoparthenolides as novel anti-leukemic agents: Discovery of the NF-kappaB inhibitor, DMAPT (LC-1).
Bioorganic & medicinal chemistry letters 2009;19(15):4346-9.
2009: Haranath K Vaddi; Stan L Banks; Jianhong Chen; Dana Carmel Hammell; Peter A Crooks; Audra Stinchcomb
Human skin permeation of 3-O-alkyl carbamate prodrugs of naltrexone.
Journal of pharmaceutical sciences 2009;98(8):2611-25.
2009: Fang Zheng; Matthew J McConnell; Chang-Guo Zhan; Linda P Dwoskin; Peter A Crooks
QSAR study on maximal inhibition (Imax) of quaternary ammonium antagonists for S-(-)-nicotine-evoked dopamine release from dopaminergic nerve terminals in rat striatum.
Bioorganic & medicinal chemistry 2009;17(13):4477-85.
2009: Fang Zheng; Guangrong Zheng; Agripina G Deaciuc; Chang-Guo Zhan; Linda P Dwoskin; Peter A Crooks
Computational neural network analysis of the affinity of N-n-alkylnicotinium salts for the alpha4beta2* nicotinic acetylcholine receptor.
Journal of enzyme inhibition and medicinal chemistry 2009;24(1):157-68.
2009: Vijayakumar N Sonar; Peter A Crooks
Synthesis and antitubercular activity of a series of hydrazone and nitrovinyl analogs derived from heterocyclic aldehydes.
Journal of enzyme inhibition and medicinal chemistry 2009;24(1):117-24.
2009: Paul K Kiptoo; Kalpana S Paudel; Dana Carmel Hammell; Raghotham Reddy Pinninti; Jianhong Chen; Peter A Crooks; Audra Stinchcomb
Transdermal delivery of bupropion and its active metabolite, hydroxybupropion: a prodrug strategy as an alternative approach.
Journal of pharmaceutical sciences 2009;98(2):583-94.
2009: Ahmad H Malkawi; Abeer M Al-Ghananeem; Jose de Leon; Peter A Crooks
Nicotine exposure can be detected in cerebrospinal fluid of active and passive smokers.
Journal of pharmaceutical and biomedical analysis 2009;49(1):129-32.
2009: Linda P Dwoskin; Marharyta Pivavarchyk; B Matthew Joyce; Nichole M Neugebauer; Guangrong Zheng; Zhenfa Zhang; Michael T Bardo; Peter A Crooks
Targeting reward-relevant nicotinic receptors in the discovery of novel pharmacotherapeutic agents to treat tobacco dependence.
Nebraska Symposium on Motivation. Nebraska Symposium on Motivation 2009;55():31-63.
2008: Shafiqur Rahman; Nichole M Neugebauer; Zhenfa Zhang; Peter A Crooks; Linda P Dwoskin; Michael T Bardo
The novel nicotinic receptor antagonist N,N'-dodecane-1,12-diyl-bis-3-picolinium dibromide decreases nicotine-induced dopamine metabolism in rat nucleus accumbens.
European journal of pharmacology 2008;601(1-3):103-5.
2008: Guangrong Zheng; Linda P Dwoskin; Agripina G Deaciuc; Peter A Crooks
Synthesis and evaluation of a series of homologues of lobelane at the vesicular monoamine transporter-2.
Bioorganic & medicinal chemistry letters 2008;18(24):6509-12.
2008: Zhenfa Zhang; Guangrong Zheng; Marharyta Pivavarchyk; Agripina G Deaciuc; Linda P Dwoskin; Peter A Crooks
Tetrakis-azaaromatic quaternary ammonium salts: novel subtype-selective antagonists at neuronal nicotinic receptors that mediate nicotine-evoked dopamine release.
Bioorganic & medicinal chemistry letters 2008;18(21):5753-7.
2008: Zhenfa Zhang; Paul R Lockman; Rajendar K Mittapalli; David D Allen; Linda P Dwoskin; Peter A Crooks
bis-Pyridinium cyclophanes: novel ligands with high affinity for the blood-brain barrier choline transporter.
Bioorganic & medicinal chemistry letters 2008;18(20):5622-5.
2008: Zaineb A Fadhel Albayati; Linda P Dwoskin; Peter A Crooks
Pharmacokinetics of the novel nicotinic receptor antagonist N,N'-dodecane-1,12-diyl-bis-3-picolinium dibromide in the rat.
Drug metabolism and disposition: the biological fate of chemicals 2008;36(10):2024-9.
2008: Joseph R Holtman; Peter A Crooks; Jaime K Johnson-Hardy; Marhaba Hojomat; Mark Kleven; Elzbieta P Wala
Effects of norketamine enantiomers in rodent models of persistent pain.
Pharmacology, biochemistry, and behavior 2008;90(4):676-85.
2008: Joseph R Holtman; Peter A Crooks; Jaime Johnson-Hardy; Elzbieta P Wala
Interaction between morphine and norketamine enantiomers in rodent models of nociception.
Pharmacology, biochemistry, and behavior 2008;90(4):769-77.
2008: Linda P Dwoskin; Thomas E Wooters; Sangeetha P Sumithran; Kiran B Siripurapu; B Matthew Joyce; Paul R Lockman; Vamshi K Manda; Joshua T Ayers; Zhenfa Zhang; Agripina G Deaciuc; J Michael McIntosh; Peter A Crooks; Michael T Bardo
N,N'-Alkane-diyl-bis-3-picoliniums as nicotinic receptor antagonists: inhibition of nicotine-evoked dopamine release and hyperactivity.
The Journal of pharmacology and experimental therapeutics 2008;326(2):563-76.
2008: Shama Nasim; Peter A Crooks
Antileukemic activity of aminoparthenolide analogs.
Bioorganic & medicinal chemistry letters 2008;18(14):3870-3.
2008: Stan L Banks; Raghotham R Pinninti; Harvinder S Gill; Peter A Crooks; Mark R Prausnitz; Audra Stinchcomb
Flux across [corrected] microneedle-treated skin is increased by increasing charge of naltrexone and naltrexol in vitro.
Pharmaceutical research 2008;25(7):1677-85.
2008: Ahmad H Malkawi; Abeer M Al-Ghananeem; Peter A Crooks
Development of a GC-MS assay for the determination of fentanyl pharmacokinetics in rabbit plasma after sublingual spray delivery.
The AAPS journal 2008;10(2):261-7.
2008: Balwinder S Bhatti; Jon-Paul Strachan; Scott R Breining; Craig H Miller; Persida Tahiri; Peter A Crooks; Niranjan Deo; Cynthia S Day; William S Caldwell
Synthesis of 2-(pyridin-3-yl)-1-azabicyclo[3.2.2]nonane, 2-(pyridin-3-yl)-1-azabicyclo[2.2.2]octane, and 2-(pyridin-3-yl)-1-azabicyclo[3.2.1]octane, a class of potent nicotinic acetylcholine receptor-ligands.
The Journal of organic chemistry 2008;73(9):3497-507.
2008: Paul K Kiptoo; Kalpana S Paudel; Dana Carmel Hammell; Mohamed O Hamad; Peter A Crooks; Audra Stinchcomb
In vivo evaluation of a transdermal codrug of 6-beta-naltrexol linked to hydroxybupropion in hairless guinea pigs.
European journal of pharmaceutical sciences : official journal of the European Federation for Pharmaceutical Sciences 2008;33(4-5):371-9.
2007: Guangrong Zheng; Zhenfa Zhang; Marharyta Pivavarchyk; Agripina G Deaciuc; Linda P Dwoskin; Peter A Crooks
Bis-azaaromatic quaternary ammonium salts as antagonists at nicotinic receptors mediating nicotine-evoked dopamine release: An investigation of binding conformation.
Bioorganic & medicinal chemistry letters 2007;17(24):6734-8.
2007: Vijayakumar N Sonar; Y Thirupathi Reddy; SEKHAR KONJETI; Soumya Sasi; Michael L Freeman; Peter A Crooks
Novel substituted (Z)-2-(N-benzylindol-3-ylmethylene)quinuclidin-3-one and (Z)-(+/-)-2-(N-benzylindol-3-ylmethylene)quinuclidin-3-ol derivatives as potent thermal sensitizing agents.
Bioorganic & medicinal chemistry letters 2007;17(24):6821-4.
2007: Guangrong Zheng; Sangeetha P Sumithran; Agripina G Deaciuc; Linda P Dwoskin; Peter A Crooks
Tris-azaaromatic quaternary ammonium salts: Novel templates as antagonists at nicotinic receptors mediating nicotine-evoked dopamine release.
Bioorganic & medicinal chemistry letters 2007;17(24):6701-6.
2007: Vijayakumar N Sonar; Sean Parkin; Peter A Crooks
(E)-3-(benzo[b]thiophen-2-yl)-2-(3,4,5-trimethoxyphenyl)acrylonitrile and (Z)-3-(benzo[b]thiophen-2-yl)-2-(3,4-dimethoxyphenyl)acrylonitrile.
Acta crystallographica. Section C, Crystal structure communications 2007;63(Pt 12):o743-5.
2007: Abeer M Al-Ghananeem; Zaineb F Albayati; Ahmad H Malkawi; Vijayakumar N Sonar; Michael L Freeman; Peter A Crooks
A pharmacokinetic study on Z-(+/-)-2-(1-benzylindole-3-yl-methylene)azabicyclo[2.2.2]octane-3-ol; a novel radio-sensitization agent.
Cancer chemotherapy and pharmacology 2007;60(6):915-9.
2007: Linda P Dwoskin; B Matthew Joyce; Guangrong Zheng; Nichole M Neugebauer; Vamshi K Manda; Paul R Lockman; Roger L Papke; Michael T Bardo; Peter A Crooks
Discovery of a novel nicotinic receptor antagonist for the treatment of nicotine addiction: 1-(3-Picolinium)-12-triethylammonium-dodecane dibromide (TMPD).
Biochemical pharmacology 2007;74(8):1271-82.
2007: Nichole M Neugebauer; Steven B Harrod; Dustin J Stairs; Peter A Crooks; Linda P Dwoskin; Michael T Bardo
Lobelane decreases methamphetamine self-administration in rats.
European journal of pharmacology 2007;571(1):33-8.
2007: Ahmad H Malkawi; Abeer M Al-Ghananeem; Shama Nasim; Jose de Leon; Peter A Crooks
An HPLC method for the simultaneous determination of neurotoxic dipyridyl isomers in human plasma.
Journal of pharmaceutical and biomedical analysis 2007;45(1):120-4.
2007: Yulan Sun; Daret K St Clair; Fang Fang; Graham W Warren; Vivek M Rangnekar; Peter A Crooks; William St Clair
The radiosensitization effect of parthenolide in prostate cancer cells is mediated by nuclear factor-kappaB inhibition and enhanced by the presence of PTEN.
Molecular cancer therapeutics 2007;6(9):2477-86.
2007: Vijayakumar N Sonar; M Venkatraj; Sean Parkin; Peter A Crooks
rac-(Z)-2-(2-Thienylmethylene)-1-azabicyclo[2.2.2]octan-3-ol.
Acta crystallographica. Section C, Crystal structure communications 2007;63(Pt 8):o493-5.
2007: Joshua R Ring; Sean Parkin; Peter A Crooks
(4-Methoxy-3-nitrobenzylideneamino)guanidinium chloride.
Acta crystallographica. Section C, Crystal structure communications 2007;63(Pt 7):o392-4.
2007: Michelle Howard-Sparks; Abeer M Al-Ghananeem; Peter A Crooks; Andrew P Pearson
A novel chemical delivery system comprising an ocular sustained release formulation of a 3alpha, 17alpha, 21-trihydroxy-5beta-pregnan-20-one-BIS-5-fluorouracil [correction of flourouracil] codrug.
Drug development and industrial pharmacy 2007;33(6):677-82.
2007: Abeer M Al-Ghananeem; Ahmad H Malkawi; Peter A Crooks
Scopolamine sublingual spray: an alternative route of delivery for the treatment of motion sickness.
Drug development and industrial pharmacy 2007;33(5):577-82.
2007: Vijayakumar N Sonar; M Venkatraj; Sean Parkin; Peter A Crooks
(Z)-2-[(1-Phenylsulfonyl-1H-indol-3-yl)methylene]-1-azabicyclo[2.2.2]octan-3-one semicarbazone.
Acta crystallographica. Section C, Crystal structure communications 2007;63(Pt 5):o277-9.
2007: Fang Zheng; Guangrong Zheng; Agripina G Deaciuc; Chang-Guo Zhan; Linda P Dwoskin; Peter A Crooks
Computational neural network analysis of the affinity of lobeline and tetrabenazine analogs for the vesicular monoamine transporter-2.
Bioorganic & medicinal chemistry 2007;15(8):2975-92.
2007: Lisa S Middleton; Peter A Crooks; Peter J Wedlund; Wayne A Cass; Linda P Dwoskin
Nornicotine inhibition of dopamine transporter function in striatum via nicotinic receptor activation.
Synapse (New York, N.Y.) 2007;61(3):157-65.
2007: Shafiqur Rahman; Nichole M Neugebauer; Zhiming Zhang; Peter A Crooks; Linda P Dwoskin; Michael T Bardo
The effects of a novel nicotinic receptor antagonist N,N-dodecane-1,12-diyl-bis-3-picolinium dibromide (bPiDDB) on acute and repeated nicotine-induced increases in extracellular dopamine in rat nucleus accumbens.
Neuropharmacology 2007;52(3):755-63.
2007: Vijayakumar N Sonar; Sean Parkin; Peter A Crooks
(Z)-2-(1-Benzyl-5-nitro-1H-indol-3-ylmethylene)-1-azabicyclo[2.2.2]octan-3-one.
Acta crystallographica. Section C, Crystal structure communications 2007;63(Pt 2):o135-6.
2007: Dustin J Stairs; Nichole M Neugebauer; X Wei; Carine M Boustany; M Hojahmat; L A Cassis; Peter A Crooks; Linda P Dwoskin; Michael T Bardo
Effects of nornicotine enantiomers on intravenous S(-)-nicotine self-administration and cardiovascular function in rats.
Psychopharmacology 2007;190(2):145-55.
2007: SEKHAR KONJETI; Vijayakumar N Sonar; Venkatraj Muthusamy; Soumya Sasi; Andrei Laszlo; Jamil Sawani; Nobuo Horikoshi; Ryuji Higashikubo; Robert G Bristow; Michael J Borrelli; Peter A Crooks; James R Lepock; Joseph L Roti Roti; Michael L Freeman
Novel chemical enhancers of heat shock increase thermal radiosensitization through a mitotic catastrophe pathway.
Cancer research 2007;67(2):695-701.
2007: Abeer M Al-Ghananeem; Peter A Crooks
Phase I and phase II ocular metabolic activities and the role of metabolism in ophthalmic prodrug and codrug design and delivery.
Molecules (Basel, Switzerland) 2007;12(3):373-88.
2007: Buchi N Nalluri; K P R Chowdary; K V Ramana Murthy; G Becket; Peter A Crooks
Tablet formulation studies on nimesulide and meloxicam-cyclodextrin binary systems.
AAPS PharmSciTech 2007;8(2):Article 36.
2006: Xiaoqin Huang; Fang Zheng; Xi Chen; Peter A Crooks; Linda P Dwoskin; Chang-Guo Zhan
Modeling subtype-selective agonists binding with alpha4beta2 and alpha7 nicotinic acetylcholine receptors: effects of local binding and long-range electrostatic interactions.
Journal of medicinal chemistry 2006;49(26):7661-74.
2006: Jianhong Chen; Agripina G Deaciuc; Linda P Dwoskin; Peter A Crooks; Donglu Bai
N, N -disubstituted piperazines and homopiperazines: synthesis and affinities at alpha4beta2* and alpha7* neuronal nicotinic acetylcholine receptors.
Journal of enzyme inhibition and medicinal chemistry 2006;21(6):667-80.
2006: Mohamed O Hamad; Paul K Kiptoo; Audra Stinchcomb; Peter A Crooks
Synthesis and hydrolytic behavior of two novel tripartate codrugs of naltrexone and 6beta-naltrexol with hydroxybupropion as potential alcohol abuse and smoking cessation agents.
Bioorganic & medicinal chemistry 2006;14(20):7051-61.
2006: Guangrong Zheng; David B Horton; Agripina G Deaciuc; Linda P Dwoskin; Peter A Crooks
Des-keto lobeline analogs with increased potency and selectivity at dopamine and serotonin transporters.
Bioorganic & medicinal chemistry letters 2006;16(19):5018-21.
2006: Peter A Crooks; Santosh G Kottayil; Abeer M Al-Ghananeem; Stephen R Byrn; D Allan Butterfield
Opiate receptor binding properties of morphine-, dihydromorphine-, and codeine 6-O-sulfate ester congeners.
Bioorganic & medicinal chemistry letters 2006;16(16):4291-5.
2006: Paul K Kiptoo; Mohamed O Hamad; Peter A Crooks; Audra Stinchcomb
Enhancement of transdermal delivery of 6-beta-naltrexol via a codrug linked to hydroxybupropion.
Journal of controlled release : official journal of the Controlled Release Society 2006;113(2):137-45.
2006: Fang Zheng; Ersin Bayram; Sangeetha P Sumithran; Joshua T Ayers; Chang-Guo Zhan; Jeffrey D Schmitt; Linda P Dwoskin; Peter A Crooks
QSAR modeling of mono- and bis-quaternary ammonium salts that act as antagonists at neuronal nicotinic acetylcholine receptors mediating dopamine release.
Bioorganic & medicinal chemistry 2006;14(9):3017-37.
2006: Shyamala Chandrasekaran; Abeer M Al-Ghananeem; Robert M Riggs; Peter A Crooks
Synthesis and stability of two indomethacin prodrugs.
Bioorganic & medicinal chemistry letters 2006;16(7):1874-9.
2006: Vijayakumar N Sonar; Sean Parkin; Peter A Crooks
1-(1H-Indol-3-ylcarbonyl)-N-(4-methoxybenzyl)formamide.
Acta crystallographica. Section C, Crystal structure communications 2006;62(Pt 3):o153-4.
2006: Nichole M Neugebauer; Zhiming Zhang; Peter A Crooks; Linda P Dwoskin; Michael T Bardo
Effect of a novel nicotinic receptor antagonist, N,N'-dodecane-1,12-diyl-bis-3-picolinium dibromide, on nicotine self-administration and hyperactivity in rats.
Psychopharmacology 2006;184(3-4):426-34.
2006: Guangrong Zheng; Linda P Dwoskin; Peter A Crooks
Vesicular monoamine transporter 2: role as a novel target for drug development.
The AAPS journal 2006;8(4):E682-92.
2006: Abeer M Al-Ghananeem; Ahmad H Malkawi; Peter A Crooks
Effect of pH on sublingual absorption of oxycodone hydrochloride.
AAPS PharmSciTech 2006;7(1):E23.
2005: Xiaochen Wei; Sangeetha P Sumithran; Agripina G Deaciuc; Harold R Burton; Lowell Bush; Linda P Dwoskin; Peter A Crooks
Identification and synthesis of novel alkaloids from the root system of Nicotiana tabacum: affinity for neuronal nicotinic acetylcholine receptors.
Life sciences 2005;78(5):495-505.
2005: Vijayakumar N Sonar; Sean Parkin; Peter A Crooks
(Z)-2-(3-methoxybenzylidene)-1-azabicyclo[2.2.2]octan-3-one.
Acta crystallographica. Section C, Crystal structure communications 2005;61(Pt 11):o660-1.
2005: Xiaoqin Huang; Fang Zheng; Peter A Crooks; Linda P Dwoskin; Chang-Guo Zhan
Modeling multiple species of nicotine and deschloroepibatidine interacting with alpha4beta2 nicotinic acetylcholine receptor: from microscopic binding to phenomenological binding affinity.
Journal of the American Chemical Society 2005;127(41):14401-14.
2005: Guangrong Zheng; Linda P Dwoskin; Agripina G Deaciuc; Peter A Crooks
Synthesis and evaluation of a series of tropane analogues as novel vesicular monoamine transporter-2 ligands.
Bioorganic & medicinal chemistry letters 2005;15(20):4463-6.
2005: Michelle Howard-Sparks; Abeer M Al-Ghananeem; Andrew P Pearson; Peter A Crooks
Evaluation of O(3alpha)-, O(21)-di-(N(1)-methyloxycarbonyl-2, 4-dioxo-5-fluoropyrimidinyl) 17alpha-hydroxy-5beta-pregnan-20-one as a novel potential antiangiogenic codrug.
Journal of enzyme inhibition and medicinal chemistry 2005;20(5):417-28.
2005: Buchi N Nalluri; Caitlin Milligan; Jianhong Chen; Peter A Crooks; Audra Stinchcomb
In vitro release studies on matrix type transdermal drug delivery systems of naltrexone and its acetyl prodrug.
Drug development and industrial pharmacy 2005;31(9):871-7.
2005: Kalpana S Paudel; Buchi N Nalluri; Dana Carmel Hammell; Satyanarayana Valiveti; Paul K Kiptoo; Mohamed O Hamad; Peter A Crooks; Audra Stinchcomb
Transdermal delivery of naltrexone and its active metabolite 6-beta-naltrexol in human skin in vitro and guinea pigs in vivo.
Journal of pharmaceutical sciences 2005;94(9):1965-75.
2005: Guangrong Zheng; Linda P Dwoskin; Agripina G Deaciuc; Seth D Norrholm; Peter A Crooks
Defunctionalized lobeline analogues: structure-activity of novel ligands for the vesicular monoamine transporter.
Journal of medicinal chemistry 2005;48(17):5551-60.
2005: Vijayakumar N Sonar; Sean Parkin; Peter A Crooks
(E)-2-Methyl-3-(2-methyl-2-nitrovinyl)-1H-indole and (E)-3-(2-methyl-2-nitrovinyl)-2-phenyl-1H-indole.
Acta crystallographica. Section C, Crystal structure communications 2005;61(Pt 8):o527-30.
2005: Grazyna Cynkowska; Tadeusz Cynkowski; Abeer M Al-Ghananeem; Abeer A Al-Ghananeem; Hong Guo; Paul Ashton; Peter A Crooks
Novel antiglaucoma prodrugs and codrugs of ethacrynic acid.
Bioorganic & medicinal chemistry letters 2005;15(15):3524-7.
2005: Guangrong Zheng; Linda P Dwoskin; Agripina G Deaciuc; Jun Zhu; Marlon D Jones; Peter A Crooks
Lobelane analogues as novel ligands for the vesicular monoamine transporter-2.
Bioorganic & medicinal chemistry 2005;13(12):3899-909.
2005: Satyanarayana Valiveti; Kalpana S Paudel; Dana Carmel Hammell; Mohamed O Hamad; Jianhong Chen; Peter A Crooks; Audra Stinchcomb
In vitro/in vivo correlation of transdermal naltrexone prodrugs in hairless guinea pigs.
Pharmaceutical research 2005;22(6):981-9.
2005: Haranath K Vaddi; Mohamed O Hamad; Jianhong Chen; Stan L Banks; Peter A Crooks; Audra Stinchcomb
Human skin permeation of branched-chain 3-0-alkyl ester and carbonate prodrugs of naltrexone.
Pharmaceutical research 2005;22(5):758-65.
2005: Dana Carmel Hammell; Elzbieta I Stolarczyk; Mitch Klausner; Mohamed O Hamad; Peter A Crooks; Audra Stinchcomb
Bioconversion of naltrexone and its 3-O-alkyl-ester prodrugs in a human skin equivalent.
Journal of pharmaceutical sciences 2005;94(4):828-36.
2005: Satyanarayana Valiveti; Dana Carmel Hammell; Kalpana S Paudel; Mohamed O Hamad; Peter A Crooks; Audra Stinchcomb
In vivo evaluation of 3-O-alkyl ester transdermal prodrugs of naltrexone in hairless guinea pigs.
Journal of controlled release : official journal of the Controlled Release Society 2005;102(2):509-20.
2005: Vijayakumar N Sonar; Sean Parkin; Peter A Crooks
(Z)-3-(1H-Indol-3-yl)-2-(3-thienyl)acrylonitrile and (Z)-3-[1-(4-tert-butylbenzyl)-1H-indol-3-yl]-2-(3-thienyl)acrylonitrile.
Acta crystallographica. Section C, Crystal structure communications 2005;61(Pt 2):o78-80.
2005: Lincoln H Wilkins; Dennis K Miller; Joshua T Ayers; Peter A Crooks; Linda P Dwoskin
N-n-alkylnicotinium analogs, a novel class of antagonists at alpha 4 beta 2* nicotinic acetylcholine receptors: inhibition of S(-)-nicotine-evoked 86Rb+ efflux from rat thalamic synaptosomes.
The AAPS journal 2005;7(4):E922-30.
2005: Joshua T Ayers; Rui Xu; Linda P Dwoskin; Peter A Crooks
A general procedure for the enantioselective synthesis of the minor tobacco alkaloids nornicotine, anabasine, and anatabine.
The AAPS journal 2005;7(3):E752-8.
2005: Joshua T Ayers; Aaron Clauset; Jeffrey D Schmitt; Linda P Dwoskin; Peter A Crooks
Molecular modeling of mono- and bis-quaternary ammonium salts as ligands at the alpha4beta2 nicotinic acetylcholine receptor subtype using nonlinear techniques.
The AAPS journal 2005;7(3):E678-85.
2005: Sangeetha P Sumithran; Peter A Crooks; Rui Xu; Jun Zhu; Agripina G Deaciuc; Lincoln H Wilkins; Linda P Dwoskin
Introduction of unsaturation into the N-n-alkyl chain of the nicotinic receptor antagonists, NONI and NDNI: effect on affinity and selectivity.
The AAPS journal 2005;7(1):E201-17.
2004: Guangrong Zheng; Linda P Dwoskin; Peter A Crooks
Indirect trapping of the retroconjugate addition reaction intermediate involved in the epimerization of lobeline: application to the synthesis of (-)-sedamine.
The Journal of organic chemistry 2004;69(24):8514-7.
2004: Shenggang Li; Peter A Crooks; Xiaochen Wei; Jose de Leon
Toxicity of dipyridyl compounds and related compounds.
Critical reviews in toxicology 2004;34(5):447-60.
2004: Vijayakumar N Sonar; Sean Parkin; Peter A Crooks
(Z)-2-(1-Phenylsulfonyl-1H-indol-3-ylmethylene)-1-azabicyclo[2.2.2]octan-3-one and (Z)-(S)-2-(1-phenylsulfonyl-1H-indol-3-ylmethylene)-1-azabicyclo[2.2.2]octan-3-ol.
Acta crystallographica. Section C, Crystal structure communications 2004;60(Pt 9):o659-61.
2004: Dennis K Miller; Peter A Crooks; Guangrong Zheng; Vladimir P Grinevich; Seth D Norrholm; Linda P Dwoskin
Lobeline analogs with enhanced affinity and selectivity for plasmalemma and vesicular monoamine transporters.
The Journal of pharmacology and experimental therapeutics 2004;310(3):1035-45.
2004: Vijayakumar N Sonar; Sean Parkin; Peter A Crooks
(E)-N-[(Benzo[b]thiophen-3-yl)methylene]-N'-(2,5-dichlorophenyl)hydrazine.
Acta crystallographica. Section C, Crystal structure communications 2004;60(Pt 8):o550-1.
2004: Vijayakumar N Sonar; Sean Parkin; Peter A Crooks
1-(2,5-Dichlorophenyl)-3-methyl-5-phenyl-1H-pyrazole.
Acta crystallographica. Section C, Crystal structure communications 2004;60(Pt 8):o547-9.
2004: Omathanu Pillai; Mohamed O Hamad; Peter A Crooks; Audra Stinchcomb
Physicochemical evaluation, in vitro human skin diffusion, and concurrent biotransformation of 3-O-alkyl carbonate prodrugs of naltrexone.
Pharmaceutical research 2004;21(7):1146-52.
2004: Dana Carmel Hammell; Mohamed O Hamad; Haranath K Vaddi; Peter A Crooks; Audra Stinchcomb
A duplex "Gemini" prodrug of naltrexone for transdermal delivery.
Journal of controlled release : official journal of the Controlled Release Society 2004;97(2):283-90.
2004: Peter A Crooks; Joshua T Ayers; Rui Xu; Sangeetha P Sumithran; Vladimir P Grinevich; Lincoln H Wilkins; Agripina G Deaciuc; David D Allen; Linda P Dwoskin
Development of subtype-selective ligands as antagonists at nicotinic receptors mediating nicotine-evoked dopamine release.
Bioorganic & medicinal chemistry letters 2004;14(8):1869-74.
2004: Linda P Dwoskin; Sangeetha P Sumithran; Jun Zhu; Agripina G Deaciuc; Joshua T Ayers; Peter A Crooks
Subtype-selective nicotinic receptor antagonists: potential as tobacco use cessation agents.
Bioorganic & medicinal chemistry letters 2004;14(8):1863-7.
2004: Vijayakumar N Sonar; Sean Parkin; Peter A Crooks
(Z)-3-(1-Methyl-1H-indol-3-yl)-2-(thiophen-3-yl)acrylonitrile.
Acta crystallographica. Section C, Crystal structure communications 2004;60(Pt 3):o217-8.
2004: Guangrong Zheng; Sean Parkin; Linda P Dwoskin; Peter A Crooks
Two isomers of 2,4-dibenzyl-8-azabicyclo[3.2.1]octan-3-ol.
Acta crystallographica. Section C, Crystal structure communications 2004;60(Pt 1):o9-11.
2004: Vijayakumar N Sonar; Sean Parkin; Peter A Crooks
(Z)-2-(1H-Indol-3-ylmethylene)-1-azabicyclo[2.2.2]octan-3-one.
Acta crystallographica. Section C, Crystal structure communications 2004;60(Pt 1):o6-8.
2003: Paul B Balbo; Chandra N Patel; Korie G Sell; Robert S Adcock; Sundar Neelakantan; Peter A Crooks; marcos oliveira
Spectrophotometric and steady-state kinetic analysis of the biosynthetic arginine decarboxylase of Yersinia pestis utilizing arginine analogues as inhibitors and alternative substrates.
Biochemistry 2003;42(51):15189-96.
2003: Vijayakumar N Sonar; Sean Parkin; Peter A Crooks
(Z)-2-(3-hydroxy-4-methoxybenzylidene)-1-azabicyclo[2.2.2]octan-3-one.
Acta crystallographica. Section C, Crystal structure communications 2003;59(Pt 11):o647-9.
2003: Aimee K Bence; Peter A Crooks
The mechanism of L-canavanine cytotoxicity: arginyl tRNA synthetase as a novel target for anticancer drug discovery.
Journal of enzyme inhibition and medicinal chemistry 2003;18(5):383-94.
2003: SEKHAR KONJETI; Peter A Crooks; Vijayakumar N Sonar; David B Friedman; Jefferson Y Chan; Michael J (Michael) Meredith; Joseph H Starnes; Kathy R Kelton; Samantha R Summar; Soumya Sasi; Michael L Freeman
NADPH oxidase activity is essential for Keap1/Nrf2-mediated induction of GCLC in response to 2-indol-3-yl-methylenequinuclidin-3-ols.
Cancer research 2003;63(17):5636-45.
2003: Vladimir P Grinevich; Peter A Crooks; Sangeetha P Sumithran; Aaron J Haubner; Joshua T Ayers; Linda P Dwoskin
N-n-alkylpyridinium analogs, a novel class of nicotinic receptor antagonists: selective inhibition of nicotine-evoked [3H] dopamine overflow from superfused rat striatal slices.
The Journal of pharmacology and experimental therapeutics 2003;306(3):1011-20.
2003: Jose de Leon; Francisco J Diaz; Thea Rogers; Debra Browne; Lori Dinsmore; Omar A Ghosheh; Linda P Dwoskin; Peter A Crooks
Plasma cotinine, 3'-hydroxycotinine, and their glucuronides in white and black smokers.
Journal of clinical psychopharmacology 2003;23(2):209-11.
2003: Aimee K Bence; Val R Adams; Peter A Crooks
L-Canavanine as a radiosensitization agent for human pancreatic cancer cells.
Molecular and cellular biochemistry 2003;244(1-2):37-43.
2003: Jose de Leon; Francisco J Diaz; Thea Rogers; Debra Browne; Lori Dinsmore; Omar H Ghosheh; Linda P Dwoskin; Peter A Crooks
A pilot study of plasma caffeine concentrations in a US sample of smoker and nonsmoker volunteers.
Progress in neuro-psychopharmacology & biological psychiatry 2003;27(1):165-71.
2003: Aimee K Bence; David R Worthen; James P Stables; Peter A Crooks
An in vivo evaluation of the antiseizure activity and acute neurotoxicity of agmatine.
Pharmacology, biochemistry, and behavior 2003;74(3):771-5.
2003: Lincoln H Wilkins; Vladimir P Grinevich; Joshua T Ayers; Peter A Crooks; Linda P Dwoskin
N-n-alkylnicotinium analogs, a novel class of nicotinic receptor antagonists: interaction with alpha4beta2* and alpha7* neuronal nicotinic receptors.
The Journal of pharmacology and experimental therapeutics 2003;304(1):400-10.
2002: Joshua T Ayers; Linda P Dwoskin; Agripina G Deaciuc; Vladimir P Grinevich; Jun Zhu; Peter A Crooks
bis-Azaaromatic quaternary ammonium analogues: ligands for alpha4beta2* and alpha7* subtypes of neuronal nicotinic receptors.
Bioorganic & medicinal chemistry letters 2002;12(21):3067-71.
2002: Joshua R Ring; Aaron J Haubner; Peter A Crooks
Novel antiepileptic and anticonvulsive therapeutic agents.
IDrugs : the investigational drugs journal 2002;5(10):990-9.
2002: Jose de Leon; Francisco J Diaz; Thea Rogers; Debra Browne; Lori Dinsmore; Omar H Ghosheh; Linda P Dwoskin; Peter A Crooks
Total cotinine in plasma: a stable biomarker for exposure to tobacco smoke.
Journal of clinical psychopharmacology 2002;22(5):496-501.
2002: Lincoln H Wilkins; Aaron J Haubner; Joshua T Ayers; Peter A Crooks; Linda P Dwoskin
N-n-alkylnicotinium analogs, a novel class of nicotinic receptor antagonist: inhibition of S(-)-nicotine-evoked [(3)H]dopamine overflow from superfused rat striatal slices.
The Journal of pharmacology and experimental therapeutics 2002;301(3):1088-96.
2002: Aimee K Bence; David R Worthen; Val R Adams; Peter A Crooks
The antiproliferative and immunotoxic effects of L-canavanine and L-canaline.
Anti-cancer drugs 2002;13(3):313-20.
2002: Linda P Dwoskin; Peter A Crooks
A novel mechanism of action and potential use for lobeline as a treatment for psychostimulant abuse.
Biochemical pharmacology 2002;63(2):89-98.
2001: Thomas A Green; Peter A Crooks; Michael T Bardo; Linda P Dwoskin
Contributory role for nornicotine in nicotine neuropharmacology: nornicotine-evoked [3H]dopamine overflow from rat nucleus accumbens slices.
Biochemical pharmacology 2001;62(12):1597-603.
2001: Linda P Dwoskin; L H Teng; Peter A Crooks
Nornicotine, a nicotine metabolite and tobacco alkaloid: desensitization of nicotinic receptor-stimulated dopamine release from rat striatum.
European journal of pharmacology 2001;428(1):69-79.
2001: Dennis K Miller; Lincoln H Wilkins; Michael T Bardo; Peter A Crooks; Linda P Dwoskin
Once weekly administration of nicotine produces long-lasting locomotor sensitization in rats via a nicotinic receptor-mediated mechanism.
Psychopharmacology 2001;156(4):469-76.
2001: Linda P Dwoskin; Peter A Crooks
Competitive neuronal nicotinic receptor antagonists: a new direction for drug discovery.
The Journal of pharmacology and experimental therapeutics 2001;298(2):395-402.
2001: Steven B Harrod; Linda P Dwoskin; Peter A Crooks; JE Klebaur; Michael T Bardo
Lobeline attenuates d-methamphetamine self-administration in rats.
The Journal of pharmacology and experimental therapeutics 2001;298(1):172-9.
2001: Rui Xu; Linda P Dwoskin; Vladimir P Grinevich; G Deaciuc; Peter A Crooks
Neuronal nicotinic acetylcholine receptor binding affinities of boron-containing nicotine analogues.
Bioorganic & medicinal chemistry letters 2001;11(9):1245-8.
2001: Omar A Ghosheh; Linda P Dwoskin; D K Miller; Peter A Crooks
Accumulation of nicotine and its metabolites in rat brain after intermittent or continuous peripheral administration of [2'-(14)C]nicotine.
Drug metabolism and disposition: the biological fate of chemicals 2001;29(5):645-51.
2001: Dennis K Miller; Peter A Crooks; L Teng; Jeffrey M Witkin; Patrik Munzar; Steven R Goldberg; JB Acri; Linda P Dwoskin
Lobeline inhibits the neurochemical and behavioral effects of amphetamine.
The Journal of pharmacology and experimental therapeutics 2001;296(3):1023-34.
2001: David R Worthen; D Alex Gibson; D Trent Rogers; Aimee K Bence; M Fu; John M Littleton; Peter A Crooks
Endogenous indoles as novel polyamine site ligands at the N-methyl-D-aspartate receptor complex.
Brain research 2001;890(2):343-6.
2000: Aimee K Bence; D Trent Rogers; David R Worthen; M Fu; John M Littleton; Peter A Crooks
Aminoanthraquinones as novel ligands at the polyamine binding site on the N-methyl-D-aspartate receptor complex.
Bioorganic & medicinal chemistry letters 2000;10(23):2621-3.
2000: Thomas A Green; Scott B Phillips; Peter A Crooks; Linda P Dwoskin; Michael T Bardo
Nornicotine pretreatment decreases intravenous nicotine self-administration in rats.
Psychopharmacology 2000;152(3):289-94.
2000: Dennis K Miller; Peter A Crooks; Linda P Dwoskin
Lobeline inhibits nicotine-evoked [(3)H]dopamine overflow from rat striatal slices and nicotine-evoked (86)Rb(+) efflux from thalamic synaptosomes.
Neuropharmacology 2000;39(13):2654-62.
2000: Omar A Ghosheh; Debra Browne; Thea Rogers; Jose de Leon; Linda P Dwoskin; Peter A Crooks
A simple high performance liquid chromatographic method for the quantification of total cotinine, total 3'-hydroxycotinine and caffeine in the plasma of smokers.
Journal of pharmaceutical and biomedical analysis 2000;23(2-3):543-9.
2000: Anwar A Hussain; J Jona; Peter A Crooks
Competitive inhibitory effect of external nucleophile concentration on intramolecular O- to N-acylation in O-acetylsalicylamide.
AAPS PharmSciTech 2000;1(3):E-TN1.
2000: Gary D Byrd; William S Caldwell; Balwinder S Bhatti; A Ravard; Peter A Crooks
Determination of nicotine N-1-glucuronide, a quaternary N-glucuronide conjugate, in human biological samples.
Drug metabolism and drug interactions 2000;16(4):281-97.
1999: Omar H Ghosheh; Linda P Dwoskin; W K Li; Peter A Crooks
Residence times and half-lives of nicotine metabolites in rat brain after acute peripheral administration of [2'-(14)C]nicotine.
Drug metabolism and disposition: the biological fate of chemicals 1999;27(12):1448-55.
1999: Michael T Bardo; Thomas A Green; Peter A Crooks; Linda P Dwoskin
Nornicotine is self-administered intravenously by rats.
Psychopharmacology 1999;146(3):290-6.
1999: Linda P Dwoskin; Peter A Crooks; L Teng; Thomas A Green; Michael T Bardo
Acute and chronic effects of nornicotine on locomotor activity in rats: altered response to nicotine.
Psychopharmacology 1999;145(4):442-51.
1999: Linda P Dwoskin; Lincoln H Wilkins; James R Pauly; Peter A Crooks
Development of a novel class of subtype-selective nicotinic receptor antagonist: pyridine-N-substituted nicotine analogs.
Annals of the New York Academy of Sciences 1999;868():617-9.
1999: Omar A Ghosheh; AA Houdi; Peter A Crooks
High performance liquid chromatographic analysis of the pharmacologically active quinones and related compounds in the oil of the black seed (Nigella sativa L.).
Journal of pharmaceutical and biomedical analysis 1999;19(5):757-62.
1999: Linda P Dwoskin; L Teng; S T Buxton; Peter A Crooks
(S)-(-)-Cotinine, the major brain metabolite of nicotine, stimulates nicotinic receptors to evoke [3H]dopamine release from rat striatal slices in a calcium-dependent manner.
The Journal of pharmacology and experimental therapeutics 1999;288(3):905-11.
1999: J H Swango; B S Bhatti; M M Qureshi; Peter A Crooks
A novel enantioselective synthesis of (S)-(-)- and (R)-(+)-nornicotine via alkylation of a chiral 2-hydroxy-3-pinanone ketimine template.
Chirality 1999;11(4):316-8.
1998: David R Worthen; L Chien; C P Tsuboi; X Y Mu; MM Bartik; Peter A Crooks
L-Canavanine modulates cellular growth, chemosensitivity and P-glycoprotein substrate accumulation in cultured human tumor cell lines.
Cancer letters 1998;132(1-2):229-39.
1998: L Teng; Peter A Crooks; Linda P Dwoskin
Lobeline displaces [3H]dihydrotetrabenazine binding and releases [3H]dopamine from rat striatal synaptic vesicles: comparison with d-amphetamine.
Journal of neurochemistry 1998;71(1):258-65.
1998: D R Worthen; O A Ghosheh; Peter A Crooks
The in vitro anti-tumor activity of some crude and purified components of blackseed, Nigella sativa L.
Anticancer research 1998;18(3A):1527-32.
1998: Merouane Bencherif; Jeffrey D Schmitt; Balwinder S Bhatti; Peter A Crooks; William S Caldwell; M E Lovette; K Fowler; L Reeves; Patrick M Lippiello
The heterocyclic substituted pyridine derivative (+/-)-2-(-3-pyridinyl)-1-azabicyclo[2.2.2]octane (RJR-2429): a selective ligand at nicotinic acetylcholine receptors.
The Journal of pharmacology and experimental therapeutics 1998;284(3):886-94.
1997: Michael T Bardo; Rick A Bevins; JE Klebaur; Peter A Crooks; Linda P Dwoskin
(-)-Nornicotine partially substitutes for (+)-amphetamine in a drug discrimination paradigm in rats.
Pharmacology, biochemistry, and behavior 1997;58(4):1083-7.
1997: L Teng; Peter A Crooks; S T Buxton; Linda P Dwoskin
Nicotinic-receptor mediation of S(-)nornicotine-evoked -3H-overflow from rat striatal slices preloaded with -3H-dopamine.
The Journal of pharmacology and experimental therapeutics 1997;283(2):778-87.
1997: Peter A Crooks; Linda P Dwoskin
Contribution of CNS nicotine metabolites to the neuropharmacological effects of nicotine and tobacco smoking.
Biochemical pharmacology 1997;54(7):743-53.
1997: L Teng; Peter A Crooks; P K Sonsalla; Linda P Dwoskin
Lobeline and nicotine evoke [3H]overflow from rat striatal slices preloaded with [3H]dopamine: differential inhibition of synaptosomal and vesicular [3H]dopamine uptake.
The Journal of pharmacology and experimental therapeutics 1997;280(3):1432-44.
1997: Peter A Crooks; M Li; Linda P Dwoskin
Metabolites of nicotine in rat brain after peripheral nicotine administration. Cotinine, nornicotine, and norcotinine.
Drug metabolism and disposition: the biological fate of chemicals 1997;25(1):47-54.
1996: SM Aziz; M N Gillespie; Peter A Crooks; S F Tofiq; C P Tsuboi; J W Olson; M P Gosland
The potential of a novel polyamine transport inhibitor in cancer chemotherapy.
The Journal of pharmacology and experimental therapeutics 1996;278(1):185-92.
1996: A A Houdi; S Kottayil; Peter A Crooks; D Allan Butterfield
3-O-acetylmorphine-6-O-sulfate: a potent, centrally acting morphine derivative.
Pharmacology, biochemistry, and behavior 1996;53(3):665-71.
1996: M P Gosland; M N Gillespie; C P Tsuboi; S Tofiq; J W Olson; Peter A Crooks; SM Aziz
Reversal of doxorubicin, etoposide, vinblastine, and taxol resistance in multidrug resistant human sarcoma cells by a polymer of spermine.
Cancer chemotherapy and pharmacology 1996;37(6):593-600.
1995: Peter A Crooks; M Li; Linda P Dwoskin
Determination of nicotine metabolites in rat brain after peripheral radiolabeled nicotine administration: detection of nornicotine.
Drug metabolism and disposition: the biological fate of chemicals 1995;23(10):1175-7.
1995: SM Aziz; M P Gosland; Peter A Crooks; J W Olson; M N Gillespie
A novel polymeric spermine conjugate inhibits polyamine transport in pulmonary artery smooth muscle cells.
The Journal of pharmacology and experimental therapeutics 1995;274(1):181-6.
1995: Linda P Dwoskin; L Teng; S T Buxton; A Ravard; N Deo; Peter A Crooks
Minor alkaloids of tobacco release [3H]dopamine from superfused rat striatal slices.
European journal of pharmacology 1995;276(1-2):195-9.
1993: A A Hussain; R Awad; Peter A Crooks; L W Dittert
Chloramine-T in radiolabeling techniques. I. Kinetics and mechanism of the reaction between chloramine-T and amino acids.
Analytical biochemistry 1993;214(2):495-9.
1993: P V Gogineni; Peter A Crooks; R B Murty
Gas chromatographic determination of residual levels of tert.-butanol from lyophilized liposomal formulations.
Journal of chromatography 1993;620(1):83-8.
1993: Linda P Dwoskin; S T Buxton; A L Jewell; Peter A Crooks
S(-)-nornicotine increases dopamine release in a calcium-dependent manner from superfused rat striatal slices.
Journal of neurochemistry 1993;60(6):2167-74.
1992: H Dannan; A Hussain; Peter A Crooks; L W Dittert
Structure-activity considerations in kinetics and mechanism of chlorine exchange between chloramine-T and secondary amines.
Journal of pharmaceutical sciences 1992;81(7):657-60.
1992: H Dannan; Peter A Crooks; L W Dittert; A Hussain
Kinetics and mechanism of chlorine exchange between chloramine-T and secondary amines.
Journal of pharmaceutical sciences 1992;81(7):652-6.
1992: Linda P Dwoskin; L L Leibee; A L Jewell; Z X Fang; Peter A Crooks
Inhibition of [3H]dopamine uptake into rat striatal slices by quaternary N-methylated nicotine metabolites.
Life sciences 1992;50(25):PL233-7.
1990: R Awad; A Hussain; Peter A Crooks
Kinetics and mechanism of decomposition of N-chloroamino acids. II: conformationally restricted models.
Journal of pharmaceutical sciences 1990;79(12):1121-2.
1990: F A Tawfig; L Dittert; A Hussain; Peter A Crooks
Rearrangement of O-acylsalicylamides via intramolecular O-to-N transacylation: rate enhancement by an adjacent carboxylic acid group.
Journal of pharmaceutical sciences 1990;79(7):651.
1989: R N Bawarshi-Nassar; A A Hussain; Peter A Crooks
Nasal absorption and metabolism of progesterone and 17 beta-estradiol in the rat.
Drug metabolism and disposition: the biological fate of chemicals 1989;17(3):248-54.
1989: R N Bawarshi-Nassar; A Hussain; Peter A Crooks
Nasal absorption of 17 alpha-ethinyloestradiol in the rat.
The Journal of pharmacy and pharmacology 1989;41(3):214-5.
1989: C S Godin; Peter A Crooks
N-methylation as a toxication route for xenobiotics. II. In vivo formation of N,N'-dimethyl-4,4'-bipyridyl ion (paraquat) from 4,4'-bipyridyl in the guinea pig.
Drug metabolism and disposition: the biological fate of chemicals 1989;17(2):180-5.
1989: Peter A Crooks; S F Hassan; E Benghiat; S K Hemrick-Luecke; R W Fuller
5'-thioadenosine derivatives as potent and selective inhibitors of histamine N-methyltransferase.
Drug metabolism and drug interactions 1989;7(2-3):111-41.
1988: C G Nwosu; Peter A Crooks
Species variation and stereoselectivity in the metabolism of nicotine enantiomers.
Xenobiotica; the fate of foreign compounds in biological systems 1988;18(12):1361-72.
1988: C G Nwosu; C S Godin; A A Houdi; Lyaquat A Damani; Peter A Crooks
Enantioselective metabolism during continuous administration of S-(-)- and R-(+)-nicotine isomers to guinea-pigs.
The Journal of pharmacy and pharmacology 1988;40(12):862-9.
1988: A A Houdi; C S Godin; Peter A Crooks
Effect of continuous administration of nicotine on urinary histamine and N tau-methylhistamine levels in the guinea pig.
Toxicology letters 1988;44(1-2):161-6.
1988: W F Pool; Peter A Crooks
Biotransformation of primary nicotine metabolites: metabolism of R-(+)-[3H-N'-CH3; 14C-N-CH3] N-methylnicotinium acetate--the use of double isotope studies to determine the in-vivo stability of the N-methyl groups of N-methylnicotinium ion.
The Journal of pharmacy and pharmacology 1988;40(11):758-62.
1988: C Gairola; C S Godin; A A Houdi; Peter A Crooks
Inhibition of histamine N-methyltransferase activity in guinea-pig pulmonary alveolar macrophages by nicotine.
The Journal of pharmacy and pharmacology 1988;40(10):724-6.
1988: Lyaquat A Damani; W F Pool; Peter A Crooks; R K Kaderlik; D M Ziegler
Stereoselectivity in the N'-oxidation of nicotine isomers by flavin-containing monooxygenase.
Molecular pharmacology 1988;33(6):702-5.
1988: Peter A Crooks; C S Godin; Lyaquat A Damani; S S Ansher; WB Jakoby
Formation of quaternary amines by N-methylation of azaheterocycles with homogeneous amine N-methyltransferases.
Biochemical pharmacology 1988;37(9):1673-7.
1988: C Y Chien; J N Diana; Peter A Crooks
High-performance liquid chromatography with electrochemical detection for the determination of nicotine in plasma.
Journal of pharmaceutical sciences 1988;77(3):277-9.
1988: Peter A Crooks; C S Godin
N-methylation of nicotine enantiomers by human liver cytosol.
The Journal of pharmacy and pharmacology 1988;40(2):153-4.
1987: K C Cundy; Peter A Crooks
Biotransformation of primary nicotine metabolites. II. Metabolism of [3H]-S-(-)-cotinine in the guinea pig: determination of in vivo urinary metabolites by high-performance liquid-radiochromatography.
Xenobiotica; the fate of foreign compounds in biological systems 1987;17(7):785-92.
1987: A A Houdi; Peter A Crooks; G R Van Loon; C A Schubert
A simple and sensitive determination of histamine and N tau-methylhistamine in biological fluids by high-performance liquid chromatography with electrochemical detection.
Journal of pharmaceutical sciences 1987;76(5):398-401.
1986: C S Godin; Peter A Crooks; Lyaquat A Damani
N-methylation of phenylpyridines and bispyridyls as a potential toxication route: tissue distribution of azaheterocycle N-methyltransferase activity in the rabbit.
Toxicology letters 1986;34(2-3):217-22.
1986: H Dannan; M N Khawam; J B Bogardus; A A Hussain; Peter A Crooks
S-acylation of cysteine by O-acetylsalicylic anhydride: a possible mechanism for aspirin hypersensitivity?
Journal of pharmaceutical sciences 1986;75(11):1081-4.
1986: W F Pool; A A Houdi; Lyaquat A Damani; W J Layton; Peter A Crooks
Isolation and characterization of N-methyl-N'-oxonicotinium ion, a new urinary metabolite of R-(+)-nicotine in the guinea pig.
Drug metabolism and disposition: the biological fate of chemicals 1986;14(5):574-9.
1986: Lyaquat A Damani; M S Shaker; Peter A Crooks; C S Godin; C Nwosu
N-methylation and quaternization of pyridine in vitro by rabbit lung, liver and kidney N-methyltransferases: an S-adenosyl-L-methionine-dependent reaction.
Xenobiotica; the fate of foreign compounds in biological systems 1986;16(7):645-50.
1986: Lyaquat A Damani; M S Shaker; C S Godin; Peter A Crooks; S S Ansher; WB Jakoby
The ability of amine N-methyltransferases from rabbit liver to N-methylate azaheterocycles.
The Journal of pharmacy and pharmacology 1986;38(7):547-50.
1986: Peter A Crooks; C S Godin; C G Nwosu; S S Ansher; WB Jakoby
Reevaluation of the products of tryptamine catalyzed by rabbit liver N-methyltransferases.
Biochemical pharmacology 1986;35(9):1600-3.
1986: E Benghiat; Peter A Crooks; R Goodwin; F Rottman
Inhibition of vaccinia RNA guanine 7-methyltransferase by compounds designed as multisubstrate adducts.
Journal of pharmaceutical sciences 1986;75(2):142-5.
1985: S Mousa; G R van Loon; A A Houdi; Peter A Crooks
High-performance liquid chromatography with electrochemical detection for the determination of nicotine and N-methylnicotinium ion.
Journal of chromatography 1985;347(3):405-10.
1985: W F Pool; Peter A Crooks
Biotransformation of primary nicotine metabolites. I. In vivo metabolism of R-(+)-[14C-NCH3]N-methylnicotinium ion in the guinea pig.
Drug metabolism and disposition: the biological fate of chemicals 1985;13(5):578-81.
1983: E Benghiat; Peter A Crooks
Multisubstrate adducts as potential inhibitors of S-adenosylmethionine dependent methylases: inhibition of indole N-methyltransferase by (5'-deoxyadenosyl)[3-(3-indolyl)prop-1-yl]methylsulfonium and (5'-deoxyadenosyl)[4-(3-indolyl)but-1-yl]methylsulfonium salts.
Journal of medicinal chemistry 1983;26(10):1470-7.
1982: Lyaquat A Damani; Peter A Crooks; M S Shaker; J Caldwell; J D'Souza; R L Smith
Species differences in the metabolic C- and N-oxidation , and N-methylation of [14C]pyridine in vivo.
Xenobiotica; the fate of foreign compounds in biological systems 1982;12(8):527-34.
1982: M S Shaker; Peter A Crooks; Lyaquat A Damani
High-performance liquid chromatographic analysis of the in vivo metabolites of [14C]pyridine.
Journal of chromatography 1982;237(3):489-95.