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Peter Crooks

This is a preview profile on BiomedExperts - the first literature-based scientific social network. It brings the right researchers together and allows them to collaborate online. Collexis and Dell provide the BiomedExperts network of +1.5 Million pre-calculated profiles free of charge to researchers worldwide.

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Co-Publications
Name
73
Dwoskin, Linda
20
Sonar, Vijayakumar
17
Deaciuc, Agripina
16
Bardo, Michael
16
Parkin, Sean
16
Zheng, Guangrong
14
Stinchcomb, Audra
12
Al-Ghananeem, Abeer
11
Ayers, Joshua
10
Hamad, Mohamed
9
Damani, Lyaquat
8
Hammell, Dana
8
Sumithran, Sangeetha
8
Zhang, Zhenfa
7
Wilkins, Lincoln

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Publications

TOP 3
Neelakantan Sundar; Surjawan Iwan; Karacelik Huseyin; Hicks Clair L; Crooks Peter A
Synthesis of novel isoluminol probes and their use in rapid bacterial assays.
Smith Andrew M; Dhawan Gurpreet K; Zhang Zhenfa; Siripurapu Kiran B; Crooks Peter A; Dwoskin Linda P
The novel nicotinic receptor antagonist, N,N'-dodecane-1,12-diyl-bis-3-picolinium dibromide (bPiDDB), inhibits nicotine-evoked [(3)H]norepinephrine overflow from rat hippocampal slices.
Dwoskin Linda P; Smith Andrew M; Wooters Thomas E; Zhang Zhenfa; Crooks Peter A; Bardo Michael T
Nicotinic receptor-based therapeutics and candidates for smoking cessation.

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All Publications

2009: Neelakantan Sundar; Surjawan Iwan; Karacelik Huseyin; Hicks Clair L; Crooks Peter A
Synthesis of novel isoluminol probes and their use in rapid bacterial assays.
Bioorganic & medicinal chemistry letters 2009;19(19):5722-6.
2009: Smith Andrew M; Dhawan Gurpreet K; Zhang Zhenfa; Siripurapu Kiran B; Crooks Peter A; Dwoskin Linda P
The novel nicotinic receptor antagonist, N,N'-dodecane-1,12-diyl-bis-3-picolinium dibromide (bPiDDB), inhibits nicotine-evoked [(3)H]norepinephrine overflow from rat hippocampal slices.
Biochemical pharmacology 2009;78(7):889-97.
2009: Dwoskin Linda P; Smith Andrew M; Wooters Thomas E; Zhang Zhenfa; Crooks Peter A; Bardo Michael T
Nicotinic receptor-based therapeutics and candidates for smoking cessation.
Biochemical pharmacology 2009;78(7):732-43.
2009: Worthen David R; Bence Aimee K; Stables James P; Crooks Peter A
In vivo evaluation of diaminodiphenyls: anticonvulsant agents with minimal acute neurotoxicity.
Bioorganic & medicinal chemistry letters 2009;19(17):5012-5.
2009: Geng Ling; Rachakonda Girish; Morré D James; Morré Dorothy M; Crooks Peter A; Sonar Vijayakumar N; Roti Joseph L Roti; Rogers Buck E; Greco Suellen; Ye Fei; Salleng Kenneth J; Sasi Soumya; Freeman Michael L; Sekhar Konjeti R
Indolyl-quinuclidinols inhibit ENOX activity and endothelial cell morphogenesis while enhancing radiation-mediated control of tumor vasculature.
The FASEB journal : official publication of the Federation of American Societies for Experimental Biology 2009;23(9):2986-95.
2009: Neelakantan Sundar; Nasim Shama; Guzman Monica L; Jordan Craig T; Crooks Peter A
Aminoparthenolides as novel anti-leukemic agents: Discovery of the NF-kappaB inhibitor, DMAPT (LC-1).
Bioorganic & medicinal chemistry letters 2009;19(15):4346-9.
2009: Vaddi Haranath K; Banks Stan L; Chen Jianhong; Hammell Dana C; Crooks Peter A; Stinchcomb Audra L
Human skin permeation of 3-O-alkyl carbamate prodrugs of naltrexone.
Journal of pharmaceutical sciences 2009;98(8):2611-25.
2009: Zheng Fang; McConnell Matthew J; Zhan Chang-Guo; Dwoskin Linda P; Crooks Peter A
QSAR study on maximal inhibition (Imax) of quaternary ammonium antagonists for S-(-)-nicotine-evoked dopamine release from dopaminergic nerve terminals in rat striatum.
Bioorganic & medicinal chemistry 2009;17(13):4477-85.
2009: Zheng Fang; Zheng Guangrong; Deaciuc A Gabriela; Zhan Chang-Guo; Dwoskin Linda P; Crooks Peter A
Computational neural network analysis of the affinity of N-n-alkylnicotinium salts for the alpha4beta2* nicotinic acetylcholine receptor.
Journal of enzyme inhibition and medicinal chemistry 2009;24(1):157-68.
2009: Sonar Vijayakumar N; Crooks Peter A
Synthesis and antitubercular activity of a series of hydrazone and nitrovinyl analogs derived from heterocyclic aldehydes.
Journal of enzyme inhibition and medicinal chemistry 2009;24(1):117-24.
2009: Kiptoo Paul K; Paudel Kalpana S; Hammell Dana C; Pinninti Raghotham Reddy; Chen Jianhong; Crooks Peter A; Stinchcomb Audra L
Transdermal delivery of bupropion and its active metabolite, hydroxybupropion: a prodrug strategy as an alternative approach.
Journal of pharmaceutical sciences 2009;98(2):583-94.
2009: Malkawi Ahmad H; Al-Ghananeem Abeer M; de Leon Jose; Crooks Peter A
Nicotine exposure can be detected in cerebrospinal fluid of active and passive smokers.
Journal of pharmaceutical and biomedical analysis 2009;49(1):129-32.
2009: Dwoskin Linda P; Pivavarchyk Marharyta; Joyce B Matthew; Neugebauer Nichole M; Zheng Guangrong; Zhang Zhenfa; Bardo Michael T; Crooks Peter A
Targeting reward-relevant nicotinic receptors in the discovery of novel pharmacotherapeutic agents to treat tobacco dependence.
Nebraska Symposium on Motivation. Nebraska Symposium on Motivation 2009;55():31-63.
2008: Rahman Shafiqur; Neugebauer Nichole M; Zhang Zhenfa; Crooks Peter A; Dwoskin Linda P; Bardo Michael T
The novel nicotinic receptor antagonist N,N'-dodecane-1,12-diyl-bis-3-picolinium dibromide decreases nicotine-induced dopamine metabolism in rat nucleus accumbens.
European journal of pharmacology 2008;601(1-3):103-5.
2008: Zheng Guangrong; Dwoskin Linda P; Deaciuc Agripina G; Crooks Peter A
Synthesis and evaluation of a series of homologues of lobelane at the vesicular monoamine transporter-2.
Bioorganic & medicinal chemistry letters 2008;18(24):6509-12.
2008: Zhang Zhenfa; Zheng Guangrong; Pivavarchyk Marharyta; Deaciuc A Gabriela; Dwoskin Linda P; Crooks Peter A
Tetrakis-azaaromatic quaternary ammonium salts: novel subtype-selective antagonists at neuronal nicotinic receptors that mediate nicotine-evoked dopamine release.
Bioorganic & medicinal chemistry letters 2008;18(21):5753-7.
2008: Zhang Zhenfa; Lockman Paul R; Mittapalli Rajendar K; Allen David D; Dwoskin Linda P; Crooks Peter A
bis-Pyridinium cyclophanes: novel ligands with high affinity for the blood-brain barrier choline transporter.
Bioorganic & medicinal chemistry letters 2008;18(20):5622-5.
2008: Albayati Zaineb A Fadhel; Dwoskin Linda P; Crooks Peter A
Pharmacokinetics of the novel nicotinic receptor antagonist N,N'-dodecane-1,12-diyl-bis-3-picolinium dibromide in the rat.
Drug metabolism and disposition: the biological fate of chemicals 2008;36(10):2024-9.
2008: Holtman Joseph R; Crooks Peter A; Johnson-Hardy Jaime K; Hojomat Marhaba; Kleven Mark; Wala Elzbieta P
Effects of norketamine enantiomers in rodent models of persistent pain.
Pharmacology, biochemistry, and behavior 2008;90(4):676-85.
2008: Holtman Joseph R; Crooks Peter A; Johnson-Hardy Jaime; Wala Elzbieta P
Interaction between morphine and norketamine enantiomers in rodent models of nociception.
Pharmacology, biochemistry, and behavior 2008;90(4):769-77.
2008: Dwoskin Linda P; Wooters Thomas E; Sumithran Sangeetha P; Siripurapu Kiran B; Joyce B Matthew; Lockman Paul R; Manda Vamshi K; Ayers Joshua T; Zhang Zhenfa; Deaciuc Agripina G; McIntosh J Michael; Crooks Peter A; Bardo Michael T
N,N'-Alkane-diyl-bis-3-picoliniums as nicotinic receptor antagonists: inhibition of nicotine-evoked dopamine release and hyperactivity.
The Journal of pharmacology and experimental therapeutics 2008;326(2):563-76.
2008: Nasim Shama; Crooks Peter A
Antileukemic activity of aminoparthenolide analogs.
Bioorganic & medicinal chemistry letters 2008;18(14):3870-3.
2008: Banks Stan L; Pinninti Raghotham R; Gill Harvinder S; Crooks Peter A; Prausnitz Mark R; Stinchcomb Audra L
Flux across [corrected] microneedle-treated skin is increased by increasing charge of naltrexone and naltrexol in vitro.
Pharmaceutical research 2008;25(7):1677-85.
2008: Malkawi Ahmad H; Al-Ghananeem Abeer M; Crooks Peter A
Development of a GC-MS assay for the determination of fentanyl pharmacokinetics in rabbit plasma after sublingual spray delivery.
The AAPS journal 2008;10(2):261-7.
2008: Bhatti Balwinder S; Strachan Jon-Paul; Breining Scott R; Miller Craig H; Tahiri Persida; Crooks Peter A; Deo Niranjan; Day Cynthia S; Caldwell William S
Synthesis of 2-(pyridin-3-yl)-1-azabicyclo[3.2.2]nonane, 2-(pyridin-3-yl)-1-azabicyclo[2.2.2]octane, and 2-(pyridin-3-yl)-1-azabicyclo[3.2.1]octane, a class of potent nicotinic acetylcholine receptor-ligands.
The Journal of organic chemistry 2008;73(9):3497-507.
2008: Kiptoo Paul K; Paudel Kalpana S; Hammell Dana C; Hamad Mohamed O; Crooks Peter A; Stinchcomb Audra L
In vivo evaluation of a transdermal codrug of 6-beta-naltrexol linked to hydroxybupropion in hairless guinea pigs.
European journal of pharmaceutical sciences : official journal of the European Federation for Pharmaceutical Sciences 2008;33(4-5):371-9.
2007: Sonar Vijayakumar N; Parkin Sean; Crooks Peter A
(E)-3-(benzo[b]thiophen-2-yl)-2-(3,4,5-trimethoxyphenyl)acrylonitrile and (Z)-3-(benzo[b]thiophen-2-yl)-2-(3,4-dimethoxyphenyl)acrylonitrile.
Acta crystallographica. Section C, Crystal structure communications 2007;63(Pt 12):o743-5.
2007: Zheng Guangrong; Zhang Zhenfa; Pivavarchyk Marharyta; Deaciuc Agripina G; Dwoskin Linda P; Crooks Peter A
Bis-azaaromatic quaternary ammonium salts as antagonists at nicotinic receptors mediating nicotine-evoked dopamine release: An investigation of binding conformation.
Bioorganic & medicinal chemistry letters 2007;17(24):6734-8.
2007: Sonar Vijayakumar N; Thirupathi Reddy Y; Sekhar Konjeti R; Sasi Soumya; Freeman Michael L; Crooks Peter A
Novel substituted (Z)-2-(N-benzylindol-3-ylmethylene)quinuclidin-3-one and (Z)-(+/-)-2-(N-benzylindol-3-ylmethylene)quinuclidin-3-ol derivatives as potent thermal sensitizing agents.
Bioorganic & medicinal chemistry letters 2007;17(24):6821-4.
2007: Zheng Guangrong; Sumithran Sangeetha P; Deaciuc Agripina G; Dwoskin Linda P; Crooks Peter A
Tris-azaaromatic quaternary ammonium salts: Novel templates as antagonists at nicotinic receptors mediating nicotine-evoked dopamine release.
Bioorganic & medicinal chemistry letters 2007;17(24):6701-6.
2007: Al-Ghananeem Abeer M; Albayati Zaineb F; Malkawi Ahmad; Sonar Vijayakumar N; Freeman Michael L; Crooks Peter A
A pharmacokinetic study on Z-(+/-)-2-(1-benzylindole-3-yl-methylene)azabicyclo[2.2.2]octane-3-ol; a novel radio-sensitization agent.
Cancer chemotherapy and pharmacology 2007;60(6):915-9.
2007: Dwoskin Linda P; Joyce B Matthew; Zheng Guangrong; Neugebauer Nichole M; Manda Vamshi K; Lockman Paul; Papke Roger L; Bardo Michael T; Crooks Peter A
Discovery of a novel nicotinic receptor antagonist for the treatment of nicotine addiction: 1-(3-Picolinium)-12-triethylammonium-dodecane dibromide (TMPD).
Biochemical pharmacology 2007;74(8):1271-82.
2007: Sun Yulan; St Clair Daret K; Fang Fang; Warren Graham W; Rangnekar Vivek M; Crooks Peter A; St Clair William H
The radiosensitization effect of parthenolide in prostate cancer cells is mediated by nuclear factor-kappaB inhibition and enhanced by the presence of PTEN.
Molecular cancer therapeutics 2007;6(9):2477-86.
2007: Malkawi Ahmad H; Al-Ghananeem Abeer M; Nasim Shama; de Leon Jose; Crooks Peter A
An HPLC method for the simultaneous determination of neurotoxic dipyridyl isomers in human plasma.
Journal of pharmaceutical and biomedical analysis 2007;45(1):120-4.
2007: Neugebauer Nichole M; Harrod Steven B; Stairs Dustin J; Crooks Peter A; Dwoskin Linda P; Bardo Michael T
Lobelane decreases methamphetamine self-administration in rats.
European journal of pharmacology 2007;571(1):33-8.
2007: Sonar Vijayakumar N; Venkatraj M; Parkin Sean; Crooks Peter A
rac-(Z)-2-(2-Thienylmethylene)-1-azabicyclo[2.2.2]octan-3-ol.
Acta crystallographica. Section C, Crystal structure communications 2007;63(Pt 8):o493-5.
2007: Ring Joshua R; Parkin Sean; Crooks Peter A
(4-Methoxy-3-nitrobenzylideneamino)guanidinium chloride.
Acta crystallographica. Section C, Crystal structure communications 2007;63(Pt 7):o392-4.
2007: Howard-Sparks Michelle; Al-Ghananeem Abeer M; Crooks Peter A; Pearson Andrew P
A novel chemical delivery system comprising an ocular sustained release formulation of a 3alpha, 17alpha, 21-trihydroxy-5beta-pregnan-20-one-BIS-5-fluorouracil [correction of flourouracil] codrug.
Drug development and industrial pharmacy 2007;33(6):677-82.
2007: Al-Ghananeem Abeer M; Malkawi Ahmad H; Crooks Peter A
Scopolamine sublingual spray: an alternative route of delivery for the treatment of motion sickness.
Drug development and industrial pharmacy 2007;33(5):577-82.
2007: Sonar Vijayakumar N; Venkatraj M; Parkin Sean; Crooks Peter A
(Z)-2-[(1-Phenylsulfonyl-1H-indol-3-yl)methylene]-1-azabicyclo[2.2.2]octan-3-one semicarbazone.
Acta crystallographica. Section C, Crystal structure communications 2007;63(Pt 5):o277-9.
2007: Zheng Fang; Zheng Guangrong; Deaciuc A Gabriela; Zhan Chang-Guo; Dwoskin Linda P; Crooks Peter A
Computational neural network analysis of the affinity of lobeline and tetrabenazine analogs for the vesicular monoamine transporter-2.
Bioorganic & medicinal chemistry 2007;15(8):2975-92.
2007: Middleton Lisa S; Crooks Peter A; Wedlund Peter J; Cass Wayne A; Dwoskin Linda P
Nornicotine inhibition of dopamine transporter function in striatum via nicotinic receptor activation.
Synapse (New York, N.Y.) 2007;61(3):157-65.
2007: Rahman Shafiqur; Neugebauer Nichole M; Zhang Z; Crooks Peter A; Dwoskin Linda P; Bardo Michael T
The effects of a novel nicotinic receptor antagonist N,N-dodecane-1,12-diyl-bis-3-picolinium dibromide (bPiDDB) on acute and repeated nicotine-induced increases in extracellular dopamine in rat nucleus accumbens.
Neuropharmacology 2007;52(3):755-63.
2007: Sonar Vijayakumar N; Parkin Sean; Crooks Peter A
(Z)-2-(1-Benzyl-5-nitro-1H-indol-3-ylmethylene)-1-azabicyclo[2.2.2]octan-3-one.
Acta crystallographica. Section C, Crystal structure communications 2007;63(Pt 2):o135-6.
2007: Stairs D J; Neugebauer N M; Wei X; Boustany C; Hojahmat M; Cassis L A; Crooks P A; Dwoskin L P; Bardo M T
Effects of nornicotine enantiomers on intravenous S(-)-nicotine self-administration and cardiovascular function in rats.
Psychopharmacology 2007;190(2):145-55.
2007: Sekhar Konjeti R; Sonar Vijayakumar N; Muthusamy Venkatraj; Sasi Soumya; Laszlo Andrei; Sawani Jamil; Horikoshi Nobuo; Higashikubo Ryuji; Bristow Robert G; Borrelli Michael J; Crooks Peter A; Lepock James R; Roti Roti Joseph L; Freeman Michael L
Novel chemical enhancers of heat shock increase thermal radiosensitization through a mitotic catastrophe pathway.
Cancer research 2007;67(2):695-701.
2007: Al-Ghananeem Abeer M; Crooks Peter A
Phase I and phase II ocular metabolic activities and the role of metabolism in ophthalmic prodrug and codrug design and delivery.
Molecules (Basel, Switzerland) 2007;12(3):373-88.
2007: Nalluri Buchi N; Chowdary K P R; Murthy K V R; Becket G; Crooks Peter A
Tablet formulation studies on nimesulide and meloxicam-cyclodextrin binary systems.
AAPS PharmSciTech 2007;8(2):Article 36.
2006: Chen Jianhong; Deaciuc Agripina G; Dwoskin Linda P; Crooks Peter A; Bai Donglu
N, N -disubstituted piperazines and homopiperazines: synthesis and affinities at alpha4beta2* and alpha7* neuronal nicotinic acetylcholine receptors.
Journal of enzyme inhibition and medicinal chemistry 2006;21(6):667-80.
2006: Huang Xiaoqin; Zheng Fang; Chen Xi; Crooks Peter A; Dwoskin Linda P; Zhan Chang-Guo
Modeling subtype-selective agonists binding with alpha4beta2 and alpha7 nicotinic acetylcholine receptors: effects of local binding and long-range electrostatic interactions.
Journal of medicinal chemistry 2006;49(26):7661-74.
2006: Zheng Guangrong; Horton David B; Deaciuc Agripina G; Dwoskin Linda P; Crooks Peter A
Des-keto lobeline analogs with increased potency and selectivity at dopamine and serotonin transporters.
Bioorganic & medicinal chemistry letters 2006;16(19):5018-21.
2006: Hamad Mohamed O; Kiptoo Paul K; Stinchcomb Audra L; Crooks Peter A
Synthesis and hydrolytic behavior of two novel tripartate codrugs of naltrexone and 6beta-naltrexol with hydroxybupropion as potential alcohol abuse and smoking cessation agents.
Bioorganic & medicinal chemistry 2006;14(20):7051-61.
2006: Crooks Peter A; Kottayil Santosh G; Al-Ghananeem Abeer M; Byrn Stephen R; Butterfield D Allan
Opiate receptor binding properties of morphine-, dihydromorphine-, and codeine 6-O-sulfate ester congeners.
Bioorganic & medicinal chemistry letters 2006;16(16):4291-5.
2006: Kiptoo Paul K; Hamad Mohamed O; Crooks Peter A; Stinchcomb Audra L
Enhancement of transdermal delivery of 6-beta-naltrexol via a codrug linked to hydroxybupropion.
Journal of controlled release : official journal of the Controlled Release Society 2006;113(2):137-45.
2006: Zheng Fang; Bayram Ersin; Sumithran Sangeetha P; Ayers Joshua T; Zhan Chang-Guo; Schmitt Jeffrey D; Dwoskin Linda P; Crooks Peter A
QSAR modeling of mono- and bis-quaternary ammonium salts that act as antagonists at neuronal nicotinic acetylcholine receptors mediating dopamine release.
Bioorganic & medicinal chemistry 2006;14(9):3017-37.
2006: Chandrasekaran Shyamala; Al-Ghananeem Abeer M; Riggs Robert M; Crooks Peter A
Synthesis and stability of two indomethacin prodrugs.
Bioorganic & medicinal chemistry letters 2006;16(7):1874-9.
2006: Sonar Vijayakumar N; Parkin Sean; Crooks Peter A
1-(1H-Indol-3-ylcarbonyl)-N-(4-methoxybenzyl)formamide.
Acta crystallographica. Section C, Crystal structure communications 2006;62(Pt 3):o153-4.
2006: Neugebauer N M; Zhang Z; Crooks P A; Dwoskin L P; Bardo M T
Effect of a novel nicotinic receptor antagonist, N,N'-dodecane-1,12-diyl-bis-3-picolinium dibromide, on nicotine self-administration and hyperactivity in rats.
Psychopharmacology 2006;184(3-4):426-34.
2006: Zheng Guangrong; Dwoskin Linda P; Crooks Peter A
Vesicular monoamine transporter 2: role as a novel target for drug development.
The AAPS journal 2006;8(4):E682-92.
2006: Al-Ghananeem Abeer M; Malkawi Ahmad H; Crooks Peter A
Effect of pH on sublingual absorption of oxycodone hydrochloride.
AAPS PharmSciTech 2006;7(1):E23.
2005: Wei Xiaochen; Sumithran Sangeetha P; Deaciuc A Gabriela; Burton Harold R; Bush Lowell P; Dwoskin Linda P; Crooks Peter A
Identification and synthesis of novel alkaloids from the root system of Nicotiana tabacum: affinity for neuronal nicotinic acetylcholine receptors.
Life sciences 2005;78(5):495-505.
2005: Sonar Vijayakumar N; Parkin Sean; Crooks Peter A
(Z)-2-(3-methoxybenzylidene)-1-azabicyclo[2.2.2]octan-3-one.
Acta crystallographica. Section C, Crystal structure communications 2005;61(Pt 11):o660-1.
2005: Howard-Sparks Michelle; Al-Ghananeem Abeer M; Pearson Andrew P; Crooks Peter A
Evaluation of O(3alpha)-, O(21)-di-(N(1)-methyloxycarbonyl-2, 4-dioxo-5-fluoropyrimidinyl) 17alpha-hydroxy-5beta-pregnan-20-one as a novel potential antiangiogenic codrug.
Journal of enzyme inhibition and medicinal chemistry 2005;20(5):417-28.
2005: Nalluri Buchi N; Milligan Caitlin; Chen Jianhong; Crooks Peter A; Stinchcomb Audra L
In vitro release studies on matrix type transdermal drug delivery systems of naltrexone and its acetyl prodrug.
Drug development and industrial pharmacy 2005;31(9):871-7.
2005: Huang Xiaoqin; Zheng Fang; Crooks Peter A; Dwoskin Linda P; Zhan Chang-Guo
Modeling multiple species of nicotine and deschloroepibatidine interacting with alpha4beta2 nicotinic acetylcholine receptor: from microscopic binding to phenomenological binding affinity.
Journal of the American Chemical Society 2005;127(41):14401-14.
2005: Zheng Guangrong; Dwoskin Linda P; Deaciuc Agripina G; Crooks Peter A
Synthesis and evaluation of a series of tropane analogues as novel vesicular monoamine transporter-2 ligands.
Bioorganic & medicinal chemistry letters 2005;15(20):4463-6.
2005: Paudel Kalpana S; Nalluri Buchi N; Hammell Dana C; Valiveti Satyanarayana; Kiptoo Paul; Hamad Mohamed O; Crooks Peter A; Stinchcomb Audra L
Transdermal delivery of naltrexone and its active metabolite 6-beta-naltrexol in human skin in vitro and guinea pigs in vivo.
Journal of pharmaceutical sciences 2005;94(9):1965-75.
2005: Zheng Guangrong; Dwoskin Linda P; Deaciuc Agripina G; Norrholm Seth D; Crooks Peter A
Defunctionalized lobeline analogues: structure-activity of novel ligands for the vesicular monoamine transporter.
Journal of medicinal chemistry 2005;48(17):5551-60.
2005: Sonar Vijayakumar N; Parkin Sean; Crooks Peter A
(E)-2-Methyl-3-(2-methyl-2-nitrovinyl)-1H-indole and (E)-3-(2-methyl-2-nitrovinyl)-2-phenyl-1H-indole.
Acta crystallographica. Section C, Crystal structure communications 2005;61(Pt 8):o527-30.
2005: Cynkowska Grazyna; Cynkowski Tadeusz; Al-Ghananeem Abeer M; Guo Hong; Ashton Paul; Crooks Peter A
Novel antiglaucoma prodrugs and codrugs of ethacrynic acid.
Bioorganic & medicinal chemistry letters 2005;15(15):3524-7.
2005: Valiveti Satyanarayana; Paudel Kalpana S; Hammell Dana C; Hamad Mohamed O; Chen Jianhong; Crooks Peter A; Stinchcomb Audra L
In vitro/in vivo correlation of transdermal naltrexone prodrugs in hairless guinea pigs.
Pharmaceutical research 2005;22(6):981-9.
2005: Zheng Guangrong; Dwoskin Linda P; Deaciuc Agripina G; Zhu Jun; Jones Marlon D; Crooks Peter A
Lobelane analogues as novel ligands for the vesicular monoamine transporter-2.
Bioorganic & medicinal chemistry 2005;13(12):3899-909.
2005: Vaddi Haranath K; Hamad Mohamed O; Chen Jianhong; Banks Stan L; Crooks Peter A; Stinchcomb Audra L
Human skin permeation of branched-chain 3-0-alkyl ester and carbonate prodrugs of naltrexone.
Pharmaceutical research 2005;22(5):758-65.
2005: Hammell Dana C; Stolarczyk Elzbieta I; Klausner Mitch; Hamad Mohamed O; Crooks Peter A; Stinchcomb Audra L
Bioconversion of naltrexone and its 3-O-alkyl-ester prodrugs in a human skin equivalent.
Journal of pharmaceutical sciences 2005;94(4):828-36.
2005: Sonar Vijayakumar N; Parkin Sean; Crooks Peter A
(Z)-3-(1H-Indol-3-yl)-2-(3-thienyl)acrylonitrile and (Z)-3-[1-(4-tert-butylbenzyl)-1H-indol-3-yl]-2-(3-thienyl)acrylonitrile.
Acta crystallographica. Section C, Crystal structure communications 2005;61(Pt 2):o78-80.
2005: Valiveti Satyanarayana; Hammell Dana C; Paudel Kalpana S; Hamad Mohamed O; Crooks Peter A; Stinchcomb Audra L
In vivo evaluation of 3-O-alkyl ester transdermal prodrugs of naltrexone in hairless guinea pigs.
Journal of controlled release : official journal of the Controlled Release Society 2005;102(2):509-20.
2005: Wilkins Lincoln H; Miller Dennis K; Ayers Joshua T; Crooks Peter A; Dwoskin Linda P
N-n-alkylnicotinium analogs, a novel class of antagonists at alpha 4 beta 2* nicotinic acetylcholine receptors: inhibition of S(-)-nicotine-evoked 86Rb+ efflux from rat thalamic synaptosomes.
The AAPS journal 2005;7(4):E922-30.
2005: Ayers Joshua T; Xu Rui; Dwoskin Linda P; Crooks Peter A
A general procedure for the enantioselective synthesis of the minor tobacco alkaloids nornicotine, anabasine, and anatabine.
The AAPS journal 2005;7(3):E752-8.
2005: Ayers Joshua T; Clauset Aaron; Schmitt Jeffrey D; Dwoskin Linda P; Crooks Peter A
Molecular modeling of mono- and bis-quaternary ammonium salts as ligands at the alpha4beta2 nicotinic acetylcholine receptor subtype using nonlinear techniques.
The AAPS journal 2005;7(3):E678-85.
2005: Sumithran Sangeetha P; Crooks Peter A; Xu Rui; Zhu Jun; Deaciuc Agripina G; Wilkins Lincoln H; Dwoskin Linda P
Introduction of unsaturation into the N-n-alkyl chain of the nicotinic receptor antagonists, NONI and NDNI: effect on affinity and selectivity.
The AAPS journal 2005;7(1):E201-17.
2004: Zheng Guangrong; Dwoskin Linda P; Crooks Peter A
Indirect trapping of the retroconjugate addition reaction intermediate involved in the epimerization of lobeline: application to the synthesis of (-)-sedamine.
The Journal of organic chemistry 2004;69(24):8514-7.
2004: Li Shenggang; Crooks Peter A; Wei Xiaochen; de Leon Jose
Toxicity of dipyridyl compounds and related compounds.
Critical reviews in toxicology 2004;34(5):447-60.
2004: Sonar Vijayakumar N; Parkin Sean; Crooks Peter A
(Z)-2-(1-Phenylsulfonyl-1H-indol-3-ylmethylene)-1-azabicyclo[2.2.2]octan-3-one and (Z)-(S)-2-(1-phenylsulfonyl-1H-indol-3-ylmethylene)-1-azabicyclo[2.2.2]octan-3-ol.
Acta crystallographica. Section C, Crystal structure communications 2004;60(Pt 9):o659-61.
2004: Miller Dennis K; Crooks Peter A; Zheng Guangrong; Grinevich Vladimir P; Norrholm Seth D; Dwoskin Linda P
Lobeline analogs with enhanced affinity and selectivity for plasmalemma and vesicular monoamine transporters.
The Journal of pharmacology and experimental therapeutics 2004;310(3):1035-45.
2004: Sonar Vijayakumar N; Parkin Sean; Crooks Peter A
(E)-N-[(Benzo[b]thiophen-3-yl)methylene]-N'-(2,5-dichlorophenyl)hydrazine.
Acta crystallographica. Section C, Crystal structure communications 2004;60(Pt 8):o550-1.
2004: Sonar Vijayakumar N; Parkin Sean; Crooks Peter A
1-(2,5-Dichlorophenyl)-3-methyl-5-phenyl-1H-pyrazole.
Acta crystallographica. Section C, Crystal structure communications 2004;60(Pt 8):o547-9.
2004: Pillai Omathanu; Hamad Mohamed O; Crooks Peter A; Stinchcomb Audra L
Physicochemical evaluation, in vitro human skin diffusion, and concurrent biotransformation of 3-O-alkyl carbonate prodrugs of naltrexone.
Pharmaceutical research 2004;21(7):1146-52.
2004: Hammell Dana C; Hamad Mohamed; Vaddi Haranath K; Crooks Peter A; Stinchcomb Audra L
A duplex "Gemini" prodrug of naltrexone for transdermal delivery.
Journal of controlled release : official journal of the Controlled Release Society 2004;97(2):283-90.
2004: Crooks Peter A; Ayers Joshua T; Xu Rui; Sumithran Sangeetha P; Grinevich Vladimir P; Wilkins Lincoln H; Deaciuc A Gabriela; Allen David D; Dwoskin Linda P
Development of subtype-selective ligands as antagonists at nicotinic receptors mediating nicotine-evoked dopamine release.
Bioorganic & medicinal chemistry letters 2004;14(8):1869-74.
2004: Dwoskin Linda P; Sumithran Sangeetha P; Zhu Jun; Deaciuc A Gabriela; Ayers Joshua T; Crooks Peter A
Subtype-selective nicotinic receptor antagonists: potential as tobacco use cessation agents.
Bioorganic & medicinal chemistry letters 2004;14(8):1863-7.
2004: Sonar Vijayakumar N; Parkin Sean; Crooks Peter A
(Z)-3-(1-Methyl-1H-indol-3-yl)-2-(thiophen-3-yl)acrylonitrile.
Acta crystallographica. Section C, Crystal structure communications 2004;60(Pt 3):o217-8.
2004: Zheng Guangrong; Parkin Sean; Dwoskin Linda P; Crooks Peter A
Two isomers of 2,4-dibenzyl-8-azabicyclo[3.2.1]octan-3-ol.
Acta crystallographica. Section C, Crystal structure communications 2004;60(Pt 1):o9-11.
2004: Sonar Vijayakumar N; Parkin Sean; Crooks Peter A
(Z)-2-(1H-Indol-3-ylmethylene)-1-azabicyclo[2.2.2]octan-3-one.
Acta crystallographica. Section C, Crystal structure communications 2004;60(Pt 1):o6-8.
2003: Balbo Paul B; Patel Chandra N; Sell Korie G; Adcock Robert S; Neelakantan Sundar; Crooks Peter A; Oliveira Marcos A
Spectrophotometric and steady-state kinetic analysis of the biosynthetic arginine decarboxylase of Yersinia pestis utilizing arginine analogues as inhibitors and alternative substrates.
Biochemistry 2003;42(51):15189-96.
2003: Sonar Vijayakumar N; Parkin Sean; Crooks Peter A
(Z)-2-(3-hydroxy-4-methoxybenzylidene)-1-azabicyclo[2.2.2]octan-3-one.
Acta crystallographica. Section C, Crystal structure communications 2003;59(Pt 11):o647-9.
2003: Bence Aimee K; Crooks Peter A
The mechanism of L-canavanine cytotoxicity: arginyl tRNA synthetase as a novel target for anticancer drug discovery.
Journal of enzyme inhibition and medicinal chemistry 2003;18(5):383-94.
2003: Sekhar Konjeti R; Crooks Peter A; Sonar Vijayakumar N; Friedman David B; Chan Jeff Y; Meredith Michael J; Starnes Joseph H; Kelton Kathy R; Summar Samantha R; Sasi Soumya; Freeman Michael L
NADPH oxidase activity is essential for Keap1/Nrf2-mediated induction of GCLC in response to 2-indol-3-yl-methylenequinuclidin-3-ols.
Cancer research 2003;63(17):5636-45.
2003: Grinevich Vladimir P; Crooks Peter A; Sumithran Sangeetha P; Haubner Aaron J; Ayers Joshua T; Dwoskin Linda P
N-n-alkylpyridinium analogs, a novel class of nicotinic receptor antagonists: selective inhibition of nicotine-evoked [3H] dopamine overflow from superfused rat striatal slices.
The Journal of pharmacology and experimental therapeutics 2003;306(3):1011-20.
2003: de Leon Jose; Diaz Francisco J; Rogers Thea; Browne Debra; Dinsmore Lori; Ghosheh Omar A; Dwoskin Linda P; Crooks Peter A
Plasma cotinine, 3'-hydroxycotinine, and their glucuronides in white and black smokers.
Journal of clinical psychopharmacology 2003;23(2):209-11.
2003: Bence Aimee K; Adams Val R; Crooks Peter A
L-Canavanine as a radiosensitization agent for human pancreatic cancer cells.
Molecular and cellular biochemistry 2003;244(1-2):37-43.
2003: de Leon Jose; Diaz Francisco J; Rogers Thea; Browne Debra; Dinsmore Lori; Ghosheh Omar H; Dwoskin Linda P; Crooks Peter A
A pilot study of plasma caffeine concentrations in a US sample of smoker and nonsmoker volunteers.
Progress in neuro-psychopharmacology & biological psychiatry 2003;27(1):165-71.
2003: Bence Aimee K; Worthen David R; Stables James P; Crooks Peter A
An in vivo evaluation of the antiseizure activity and acute neurotoxicity of agmatine.
Pharmacology, biochemistry, and behavior 2003;74(3):771-5.
2003: Wilkins Lincoln H; Grinevich Vladimir P; Ayers Joshua T; Crooks Peter A; Dwoskin Linda P
N-n-alkylnicotinium analogs, a novel class of nicotinic receptor antagonists: interaction with alpha4beta2* and alpha7* neuronal nicotinic receptors.
The Journal of pharmacology and experimental therapeutics 2003;304(1):400-10.
2002: Ayers Joshua T; Dwoskin Linda P; Deaciuc A Gabriela; Grinevich Vladimir P; Zhu Jun; Crooks Peter A
bis-Azaaromatic quaternary ammonium analogues: ligands for alpha4beta2* and alpha7* subtypes of neuronal nicotinic receptors.
Bioorganic & medicinal chemistry letters 2002;12(21):3067-71.
2002: Ring Joshua R; Haubner Aaron J; Crooks Peter A
Novel antiepileptic and anticonvulsive therapeutic agents.
IDrugs : the investigational drugs journal 2002;5(10):990-9.
2002: de Leon Jose; Diaz Francisco J; Rogers Thea; Browne Debra; Dinsmore Lori; Ghosheh Omar H; Dwoskin Linda P; Crooks Peter A
Total cotinine in plasma: a stable biomarker for exposure to tobacco smoke.
Journal of clinical psychopharmacology 2002;22(5):496-501.
2002: Wilkins Lincoln H; Haubner Aaron; Ayers Joshua T; Crooks Peter A; Dwoskin Linda P
N-n-alkylnicotinium analogs, a novel class of nicotinic receptor antagonist: inhibition of S(-)-nicotine-evoked [(3)H]dopamine overflow from superfused rat striatal slices.
The Journal of pharmacology and experimental therapeutics 2002;301(3):1088-96.
2002: Bence Aimee K; Worthen David R; Adams Val R; Crooks Peter A
The antiproliferative and immunotoxic effects of L-canavanine and L-canaline.
Anti-cancer drugs 2002;13(3):313-20.
2002: Dwoskin Linda P; Crooks Peter A
A novel mechanism of action and potential use for lobeline as a treatment for psychostimulant abuse.
Biochemical pharmacology 2002;63(2):89-98.
2001: Green T A; Crooks P A; Bardo M T; Dwoskin L P
Contributory role for nornicotine in nicotine neuropharmacology: nornicotine-evoked [3H]dopamine overflow from rat nucleus accumbens slices.
Biochemical pharmacology 2001;62(12):1597-603.
2001: Dwoskin L P; Teng L H; Crooks P A
Nornicotine, a nicotine metabolite and tobacco alkaloid: desensitization of nicotinic receptor-stimulated dopamine release from rat striatum.
European journal of pharmacology 2001;428(1):69-79.
2001: Miller D K; Wilkins L H; Bardo M T; Crooks P A; Dwoskin L P
Once weekly administration of nicotine produces long-lasting locomotor sensitization in rats via a nicotinic receptor-mediated mechanism.
Psychopharmacology 2001;156(4):469-76.
2001: Dwoskin L P; Crooks P A
Competitive neuronal nicotinic receptor antagonists: a new direction for drug discovery.
The Journal of pharmacology and experimental therapeutics 2001;298(2):395-402.
2001: Harrod S B; Dwoskin L P; Crooks P A; Klebaur J E; Bardo M T
Lobeline attenuates d-methamphetamine self-administration in rats.
The Journal of pharmacology and experimental therapeutics 2001;298(1):172-9.
2001: Xu R; Dwoskin L P; Grinevich V P; Deaciuc G; Crooks P A
Neuronal nicotinic acetylcholine receptor binding affinities of boron-containing nicotine analogues.
Bioorganic & medicinal chemistry letters 2001;11(9):1245-8.
2001: Ghosheh O A; Dwoskin L P; Miller D K; Crooks P A
Accumulation of nicotine and its metabolites in rat brain after intermittent or continuous peripheral administration of [2'-(14)C]nicotine.
Drug metabolism and disposition: the biological fate of chemicals 2001;29(5):645-51.
2001: Miller D K; Crooks P A; Teng L; Witkin J M; Munzar P; Goldberg S R; Acri J B; Dwoskin L P
Lobeline inhibits the neurochemical and behavioral effects of amphetamine.
The Journal of pharmacology and experimental therapeutics 2001;296(3):1023-34.
2001: Worthen D R; Gibson D A; Rogers D T; Bence A K; Fu M; Littleton J M; Crooks P A
Endogenous indoles as novel polyamine site ligands at the N-methyl-D-aspartate receptor complex.
Brain research 2001;890(2):343-6.
2000: Bence A K; Rogers D T; Worthen D R; Fu M; Littleton J M; Crooks P A
Aminoanthraquinones as novel ligands at the polyamine binding site on the N-methyl-D-aspartate receptor complex.
Bioorganic & medicinal chemistry letters 2000;10(23):2621-3.
2000: Green T A; Phillips S B; Crooks P A; Dwoskin L P; Bardo M T
Nornicotine pretreatment decreases intravenous nicotine self-administration in rats.
Psychopharmacology 2000;152(3):289-94.
2000: Miller D K; Crooks P A; Dwoskin L P
Lobeline inhibits nicotine-evoked [(3)H]dopamine overflow from rat striatal slices and nicotine-evoked (86)Rb(+) efflux from thalamic synaptosomes.
Neuropharmacology 2000;39(13):2654-62.
2000: Ghosheh O A; Browne D; Rogers T; de Leon J; Dwoskin L P; Crooks P A
A simple high performance liquid chromatographic method for the quantification of total cotinine, total 3'-hydroxycotinine and caffeine in the plasma of smokers.
Journal of pharmaceutical and biomedical analysis 2000;23(2-3):543-9.
2000: Hussain A A; Jona J; Crooks P A
Competitive inhibitory effect of external nucleophile concentration on intramolecular O- to N-acylation in O-acetylsalicylamide.
AAPS PharmSciTech 2000;1(3):E-TN1.
2000: Byrd G D; Caldwell W S; Bhatti B S; Ravard A; Crooks P A
Determination of nicotine N-1-glucuronide, a quaternary N-glucuronide conjugate, in human biological samples.
Drug metabolism and drug interactions 2000;16(4):281-97.
1999: Ghosheh O; Dwoskin L P; Li W K; Crooks P A
Residence times and half-lives of nicotine metabolites in rat brain after acute peripheral administration of [2'-(14)C]nicotine.
Drug metabolism and disposition: the biological fate of chemicals 1999;27(12):1448-55.
1999: Bardo M T; Green T A; Crooks P A; Dwoskin L P
Nornicotine is self-administered intravenously by rats.
Psychopharmacology 1999;146(3):290-6.
1999: Dwoskin L P; Crooks P A; Teng L; Green T A; Bardo M T
Acute and chronic effects of nornicotine on locomotor activity in rats: altered response to nicotine.
Psychopharmacology 1999;145(4):442-51.
1999: Ghosheh O A; Houdi A A; Crooks P A
High performance liquid chromatographic analysis of the pharmacologically active quinones and related compounds in the oil of the black seed (Nigella sativa L.).
Journal of pharmaceutical and biomedical analysis 1999;19(5):757-62.
1999: Dwoskin L P; Wilkins L H; Pauly J R; Crooks P A
Development of a novel class of subtype-selective nicotinic receptor antagonist: pyridine-N-substituted nicotine analogs.
Annals of the New York Academy of Sciences 1999;868():617-9.
1999: Dwoskin L P; Teng L; Buxton S T; Crooks P A
(S)-(-)-Cotinine, the major brain metabolite of nicotine, stimulates nicotinic receptors to evoke [3H]dopamine release from rat striatal slices in a calcium-dependent manner.
The Journal of pharmacology and experimental therapeutics 1999;288(3):905-11.
1999: Swango J H; Bhatti B S; Qureshi M M; Crooks P A
A novel enantioselective synthesis of (S)-(-)- and (R)-(+)-nornicotine via alkylation of a chiral 2-hydroxy-3-pinanone ketimine template.
Chirality 1999;11(4):316-8.
1998: Worthen D R; Chien L; Tsuboi C P; Mu X Y; Bartik M M; Crooks P A
L-Canavanine modulates cellular growth, chemosensitivity and P-glycoprotein substrate accumulation in cultured human tumor cell lines.
Cancer letters 1998;132(1-2):229-39.
1998: Teng L; Crooks P A; Dwoskin L P
Lobeline displaces [3H]dihydrotetrabenazine binding and releases [3H]dopamine from rat striatal synaptic vesicles: comparison with d-amphetamine.
Journal of neurochemistry 1998;71(1):258-65.
1998: Worthen D R; Ghosheh O A; Crooks P A
The in vitro anti-tumor activity of some crude and purified components of blackseed, Nigella sativa L.
Anticancer research 1998;18(3A):1527-32.
1998: Bencherif M; Schmitt J D; Bhatti B S; Crooks P; Caldwell W S; Lovette M E; Fowler K; Reeves L; Lippiello P M
The heterocyclic substituted pyridine derivative (+/-)-2-(-3-pyridinyl)-1-azabicyclo[2.2.2]octane (RJR-2429): a selective ligand at nicotinic acetylcholine receptors.
The Journal of pharmacology and experimental therapeutics 1998;284(3):886-94.
1997: Bardo M T; Bevins R A; Klebaur J E; Crooks P A; Dwoskin L P
(-)-Nornicotine partially substitutes for (+)-amphetamine in a drug discrimination paradigm in rats.
Pharmacology, biochemistry, and behavior 1997;58(4):1083-7.
1997: Teng L; Crooks P A; Buxton S T; Dwoskin L P
Nicotinic-receptor mediation of S(-)nornicotine-evoked -3H-overflow from rat striatal slices preloaded with -3H-dopamine.
The Journal of pharmacology and experimental therapeutics 1997;283(2):778-87.
1997: Crooks P A; Dwoskin L P
Contribution of CNS nicotine metabolites to the neuropharmacological effects of nicotine and tobacco smoking.
Biochemical pharmacology 1997;54(7):743-53.
1997: Teng L; Crooks P A; Sonsalla P K; Dwoskin L P
Lobeline and nicotine evoke [3H]overflow from rat striatal slices preloaded with [3H]dopamine: differential inhibition of synaptosomal and vesicular [3H]dopamine uptake.
The Journal of pharmacology and experimental therapeutics 1997;280(3):1432-44.
1997: Crooks P A; Li M; Dwoskin L P
Metabolites of nicotine in rat brain after peripheral nicotine administration. Cotinine, nornicotine, and norcotinine.
Drug metabolism and disposition: the biological fate of chemicals 1997;25(1):47-54.
1996: Aziz S M; Gillespie M N; Crooks P A; Tofiq S F; Tsuboi C P; Olson J W; Gosland M P
The potential of a novel polyamine transport inhibitor in cancer chemotherapy.
The Journal of pharmacology and experimental therapeutics 1996;278(1):185-92.
1996: Houdi A A; Kottayil S; Crooks P A; Butterfield D A
3-O-acetylmorphine-6-O-sulfate: a potent, centrally acting morphine derivative.
Pharmacology, biochemistry, and behavior 1996;53(3):665-71.
1996: Gosland M P; Gillespie M N; Tsuboi C P; Tofiq S; Olson J W; Crooks P A; Aziz S M
Reversal of doxorubicin, etoposide, vinblastine, and taxol resistance in multidrug resistant human sarcoma cells by a polymer of spermine.
Cancer chemotherapy and pharmacology 1996;37(6):593-600.
1995: Crooks P A; Li M; Dwoskin L P
Determination of nicotine metabolites in rat brain after peripheral radiolabeled nicotine administration: detection of nornicotine.
Drug metabolism and disposition: the biological fate of chemicals 1995;23(10):1175-7.
1995: Aziz S M; Gosland M P; Crooks P A; Olson J W; Gillespie M N
A novel polymeric spermine conjugate inhibits polyamine transport in pulmonary artery smooth muscle cells.
The Journal of pharmacology and experimental therapeutics 1995;274(1):181-6.
1995: Dwoskin L P; Teng L; Buxton S T; Ravard A; Deo N; Crooks P A
Minor alkaloids of tobacco release [3H]dopamine from superfused rat striatal slices.
European journal of pharmacology 1995;276(1-2):195-9.
1993: Hussain A A; Awad R; Crooks P A; Dittert L W
Chloramine-T in radiolabeling techniques. I. Kinetics and mechanism of the reaction between chloramine-T and amino acids.
Analytical biochemistry 1993;214(2):495-9.
1993: Gogineni P V; Crooks P A; Murty R B
Gas chromatographic determination of residual levels of tert.-butanol from lyophilized liposomal formulations.
Journal of chromatography 1993;620(1):83-8.
1993: Dwoskin L P; Buxton S T; Jewell A L; Crooks P A
S(-)-nornicotine increases dopamine release in a calcium-dependent manner from superfused rat striatal slices.
Journal of neurochemistry 1993;60(6):2167-74.
1992: Dannan H; Hussain A; Crooks P A; Dittert L W
Structure-activity considerations in kinetics and mechanism of chlorine exchange between chloramine-T and secondary amines.
Journal of pharmaceutical sciences 1992;81(7):657-60.
1992: Dannan H; Crooks P A; Dittert L W; Hussain A
Kinetics and mechanism of chlorine exchange between chloramine-T and secondary amines.
Journal of pharmaceutical sciences 1992;81(7):652-6.
1992: Dwoskin L P; Leibee L L; Jewell A L; Fang Z X; Crooks P A
Inhibition of [3H]dopamine uptake into rat striatal slices by quaternary N-methylated nicotine metabolites.
Life sciences 1992;50(25):PL233-7.
1990: Awad R; Hussain A; Crooks P A
Kinetics and mechanism of decomposition of N-chloroamino acids. II: conformationally restricted models.
Journal of pharmaceutical sciences 1990;79(12):1121-2.
1990: Tawfig F A; Dittert L; Hussain A; Crooks P A
Rearrangement of O-acylsalicylamides via intramolecular O-to-N transacylation: rate enhancement by an adjacent carboxylic acid group.
Journal of pharmaceutical sciences 1990;79(7):651.
1989: Bawarshi-Nassar R N; Hussain A A; Crooks P A
Nasal absorption and metabolism of progesterone and 17 beta-estradiol in the rat.
Drug metabolism and disposition: the biological fate of chemicals 1989;17(3):248-54.
1989: Bawarshi-Nassar R N; Hussain A; Crooks P A
Nasal absorption of 17 alpha-ethinyloestradiol in the rat.
The Journal of pharmacy and pharmacology 1989;41(3):214-5.
1989: Godin C S; Crooks P A
N-methylation as a toxication route for xenobiotics. II. In vivo formation of N,N'-dimethyl-4,4'-bipyridyl ion (paraquat) from 4,4'-bipyridyl in the guinea pig.
Drug metabolism and disposition: the biological fate of chemicals 1989;17(2):180-5.
1989: Crooks P A; Hassan S F; Benghiat E; Hemrick-Luecke S K; Fuller R W
5'-thioadenosine derivatives as potent and selective inhibitors of histamine N-methyltransferase.
Drug metabolism and drug interactions 1989;7(2-3):111-41.
1988: Nwosu C G; Crooks P A
Species variation and stereoselectivity in the metabolism of nicotine enantiomers.
Xenobiotica; the fate of foreign compounds in biological systems 1988;18(12):1361-72.
1988: Nwosu C G; Godin C S; Houdi A A; Damani L A; Crooks P A
Enantioselective metabolism during continuous administration of S-(-)- and R-(+)-nicotine isomers to guinea-pigs.
The Journal of pharmacy and pharmacology 1988;40(12):862-9.
1988: Houdi A A; Godin C S; Crooks P A
Effect of continuous administration of nicotine on urinary histamine and N tau-methylhistamine levels in the guinea pig.
Toxicology letters 1988;44(1-2):161-6.
1988: Pool W F; Crooks P A
Biotransformation of primary nicotine metabolites: metabolism of R-(+)-[3H-N'-CH3; 14C-N-CH3] N-methylnicotinium acetate--the use of double isotope studies to determine the in-vivo stability of the N-methyl groups of N-methylnicotinium ion.
The Journal of pharmacy and pharmacology 1988;40(11):758-62.
1988: Gairola C; Godin C S; Houdi A A; Crooks P A
Inhibition of histamine N-methyltransferase activity in guinea-pig pulmonary alveolar macrophages by nicotine.
The Journal of pharmacy and pharmacology 1988;40(10):724-6.
1988: Damani L A; Pool W F; Crooks P A; Kaderlik R K; Ziegler D M
Stereoselectivity in the N'-oxidation of nicotine isomers by flavin-containing monooxygenase.
Molecular pharmacology 1988;33(6):702-5.
1988: Crooks P A; Godin C S; Damani L A; Ansher S S; Jakoby W B
Formation of quaternary amines by N-methylation of azaheterocycles with homogeneous amine N-methyltransferases.
Biochemical pharmacology 1988;37(9):1673-7.
1988: Chien C Y; Diana J N; Crooks P A
High-performance liquid chromatography with electrochemical detection for the determination of nicotine in plasma.
Journal of pharmaceutical sciences 1988;77(3):277-9.
1988: Crooks P A; Godin C S
N-methylation of nicotine enantiomers by human liver cytosol.
The Journal of pharmacy and pharmacology 1988;40(2):153-4.
1987: Cundy K C; Crooks P A
Biotransformation of primary nicotine metabolites. II. Metabolism of [3H]-S-(-)-cotinine in the guinea pig: determination of in vivo urinary metabolites by high-performance liquid-radiochromatography.
Xenobiotica; the fate of foreign compounds in biological systems 1987;17(7):785-92.
1987: Houdi A A; Crooks P A; Van Loon G R; Schubert C A
A simple and sensitive determination of histamine and N tau-methylhistamine in biological fluids by high-performance liquid chromatography with electrochemical detection.
Journal of pharmaceutical sciences 1987;76(5):398-401.
1986: Godin C S; Crooks P A; Damani L A
N-methylation of phenylpyridines and bispyridyls as a potential toxication route: tissue distribution of azaheterocycle N-methyltransferase activity in the rabbit.
Toxicology letters 1986;34(2-3):217-22.
1986: Dannan H; Khawam M N; Bogardus J B; Hussain A A; Crooks P A
S-acylation of cysteine by O-acetylsalicylic anhydride: a possible mechanism for aspirin hypersensitivity?
Journal of pharmaceutical sciences 1986;75(11):1081-4.
1986: Pool W F; Houdi A A; Damani L A; Layton W J; Crooks P A
Isolation and characterization of N-methyl-N'-oxonicotinium ion, a new urinary metabolite of R-(+)-nicotine in the guinea pig.
Drug metabolism and disposition: the biological fate of chemicals 1986;14(5):574-9.
1986: Damani L A; Shaker M S; Crooks P A; Godin C S; Nwosu C
N-methylation and quaternization of pyridine in vitro by rabbit lung, liver and kidney N-methyltransferases: an S-adenosyl-L-methionine-dependent reaction.
Xenobiotica; the fate of foreign compounds in biological systems 1986;16(7):645-50.
1986: Damani L A; Shaker M S; Godin C S; Crooks P A; Ansher S S; Jakoby W B
The ability of amine N-methyltransferases from rabbit liver to N-methylate azaheterocycles.
The Journal of pharmacy and pharmacology 1986;38(7):547-50.
1986: Crooks P A; Godin C S; Nwosu C G; Ansher S S; Jakoby W B
Reevaluation of the products of tryptamine catalyzed by rabbit liver N-methyltransferases.
Biochemical pharmacology 1986;35(9):1600-3.
1986: Benghiat E; Crooks P A; Goodwin R; Rottman F
Inhibition of vaccinia RNA guanine 7-methyltransferase by compounds designed as multisubstrate adducts.
Journal of pharmaceutical sciences 1986;75(2):142-5.
1985: Mousa S; van Loon G R; Houdi A A; Crooks P A
High-performance liquid chromatography with electrochemical detection for the determination of nicotine and N-methylnicotinium ion.
Journal of chromatography 1985;347(3):405-10.
1985: Pool W F; Crooks P A
Biotransformation of primary nicotine metabolites. I. In vivo metabolism of R-(+)-[14C-NCH3]N-methylnicotinium ion in the guinea pig.
Drug metabolism and disposition: the biological fate of chemicals 1985;13(5):578-81.
1983: Benghiat E; Crooks P A
Multisubstrate adducts as potential inhibitors of S-adenosylmethionine dependent methylases: inhibition of indole N-methyltransferase by (5'-deoxyadenosyl)[3-(3-indolyl)prop-1-yl]methylsulfonium and (5'-deoxyadenosyl)[4-(3-indolyl)but-1-yl]methylsulfonium salts.
Journal of medicinal chemistry 1983;26(10):1470-7.
1982: Damani L A; Crooks P A; Shaker M S; Caldwell J; D'Souza J; Smith R L
Species differences in the metabolic C- and N-oxidation , and N-methylation of [14C]pyridine in vivo.
Xenobiotica; the fate of foreign compounds in biological systems 1982;12(8):527-34.
1982: Shaker M S; Crooks P A; Damani L A
High-performance liquid chromatographic analysis of the in vivo metabolites of [14C]pyridine.
Journal of chromatography 1982;237(3):489-95.

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