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John Crosby

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John Crosby; Matthew Crump; Michelle Hammerton; Tom Treadwell; Konstantinos Vasilakis; David S Williams; Stephen Mann
Stabilization and enhanced reactivity of actinorhodin polyketide synthase minimal complex in polymer-nucleotide coacervate droplets.
John Crosby; Matthew P Crump
The structural role of the carrier protein--active controller or passive carrier.
Hannah J Maple; John Porter; Christine E Prosser; Laura Rigau-Roca; Richard J Taylor; Ian Whitcombe; Matthew Crump; Rachel A Garlish; Alistair J Henry; Jeff Kennedy; John Crosby
Automated protein-ligand interaction screening by mass spectrometry.

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All Publications

2012: John Crosby; Matthew Crump; Michelle Hammerton; Tom Treadwell; Konstantinos Vasilakis; David S Williams; Stephen Mann
Stabilization and enhanced reactivity of actinorhodin polyketide synthase minimal complex in polymer-nucleotide coacervate droplets.
Chemical communications (Cambridge, England) 2012;48(97):11832-4.
2012: John Crosby; Matthew P Crump
The structural role of the carrier protein--active controller or passive carrier.
Natural product reports 2012;29(10):1111-37.
2012: Hannah J Maple; John Porter; Christine E Prosser; Laura Rigau-Roca; Richard J Taylor; Ian Whitcombe; Matthew Crump; Rachel A Garlish; Alistair J Henry; Jeff Kennedy; John Crosby
Automated protein-ligand interaction screening by mass spectrometry.
Journal of medicinal chemistry 2012;55(2):837-51.
2011: Patrick Dall'aglio; Christopher Arthur; John Crosby; Matthew Crump; Hannah J Maple; Konstantinos Vasilakis; Christopher Williams; Andrea T Hadfield
Analysis of Streptomyces coelicolor phosphopantetheinyl transferase, AcpS, reveals the basis for relaxed substrate specificity.
Biochemistry 2011;50(25):5704-17.
2011: Joanne Hothersall; Annabel C Murphy; Zafar Iqbal; Genevieve Campbell; Elton R Stephens; Ji'en Wu; Helen Cooper; Steve Atkinson; Paul Williams; John Crosby; Christine L Willis; Russell Cox; Thomas J Simpson; Christopher M Thomas
Manipulation of quorum sensing regulation in Pseudomonas fluorescens NCIMB 10586 to increase mupirocin production.
Applied microbiology and biotechnology 2011;90(3):1017-26.
2011: Daisuke Fukuda; Anthony S Haines; Zhongshu Song; Annabel C Murphy; Joanne Hothersall; Elton R Stephens; Rachel Gurney; Russell Cox; John Crosby; Christine L Willis; Thomas J Simpson; Christopher M Thomas
A natural plasmid uniquely encodes two biosynthetic pathways creating a potent anti-MRSA antibiotic.
PloS one 2011;6(3):e18031.
2010: Eliza Płoskoń; Christopher Arthur; Amelia L P Kanari; Pakorn Wattana-amorn; Christopher Williams; John Crosby; Thomas J Simpson; Christine L Willis; Matthew Crump
Recognition of intermediate functionality by acyl carrier protein over a complete cycle of fatty acid biosynthesis.
Chemistry & biology 2010;17(7):776-85.
2010: Pakorn Wattana-amorn; Christopher Williams; Eliza Płoskoń; Russell Cox; Thomas J Simpson; John Crosby; Matthew Crump
Solution structure of an acyl carrier protein domain from a fungal type I polyketide synthase.
Biochemistry 2010;49(10):2186-93.
2010: Jennifer A Shields; Ayesha S Rahman; Christopher Arthur; John Crosby; Joanne Hothersall; Thomas J Simpson; Christopher M Thomas
Phosphopantetheinylation and specificity of acyl carrier proteins in the mupirocin biosynthetic cluster.
Chembiochem : a European journal of chemical biology 2010;11(2):248-55.
2009: Christopher Arthur; Christopher Williams; Katherine Pottage; Eliza Płoskoń; Stuart C Findlow; Steven G Burston; Thomas J Simpson; Matthew Crump; John Crosby
Structure and malonyl CoA-ACP transacylase binding of streptomyces coelicolor fatty acid synthase acyl carrier protein.
ACS chemical biology 2009;4(8):625-36.
2009: Simon E Evans; Christopher Williams; Christopher Arthur; Eliza Płoskoń; Pakorn Wattana-amorn; Russell Cox; John Crosby; Christine L Willis; Thomas J Simpson; Matthew Crump
Probing the Interactions of early polyketide intermediates with the Actinorhodin ACP from S. coelicolor A3(2).
Journal of molecular biology 2009;389(3):511-28.
2009: Pedro Beltran-Alvarez; Christopher Arthur; Russell Cox; John Crosby; Matthew Crump; Thomas J Simpson
Preliminary kinetic analysis of acyl carrier protein-ketoacylsynthase interactions in the actinorhodin minimal polyketide synthase.
Molecular bioSystems 2009;5(5):511-8.
2008: Simon E Evans; Christopher Williams; Christopher Arthur; Steven G Burston; Thomas J Simpson; John Crosby; Matthew Crump
An ACP structural switch: conformational differences between the apo and holo forms of the actinorhodin polyketide synthase acyl carrier protein.
Chembiochem : a European journal of chemical biology 2008;9(15):2424-32.
2008: Ji'en Wu; Joanne Hothersall; Carlo Mazzetti; Yvonne O'Connell; Jennifer A Shields; Ayesha S Rahman; Russell Cox; John Crosby; Thomas J Simpson; Christopher M Thomas; Christine L Willis
In vivo mutational analysis of the mupirocin gene cluster reveals labile points in the biosynthetic pathway: the "leaky hosepipe" mechanism.
Chembiochem : a European journal of chemical biology 2008;9(9):1500-8.
2008: Eliza Płoskoń; Christopher Arthur; Simon E Evans; Christopher Williams; John Crosby; Thomas J Simpson; Matthew Crump
A mammalian type I fatty acid synthase acyl carrier protein domain does not sequester acyl chains.
The Journal of biological chemistry 2008;283(1):518-28.
2007: Pedro Beltran-Alvarez; Russell Cox; John Crosby; Thomas J Simpson
Dissecting the component reactions catalyzed by the actinorhodin minimal polyketide synthase.
Biochemistry 2007;46(50):14672-81.
2007: Christopher Williams; Dellel Rezgui; Stuart N Prince; Oliver J Zaccheo; Emily J Foulstone; Briony E Forbes; Raymond S Norton; John Crosby; Andrew Bassim Hassan; Matthew Crump
Structural insights into the interaction of insulin-like growth factor 2 with IGF2R domain 11.
Structure (London, England : 1993) 2007;15(9):1065-78.
2007: Ji'en Wu; Sian M Cooper; Russell Cox; John Crosby; Matthew Crump; Joanne Hothersall; Thomas J Simpson; Christopher M Thomas; Christine L Willis
Mupirocin H, a novel metabolite resulting from mutation of the HMG-CoA synthase analogue, mupH in Pseudomonas fluorescens.
Chemical communications (Cambridge, England) 2007;(20):2040-2.
2007: Joanne Hothersall; Ji'en Wu; Ayesha S Rahman; Jennifer A Shields; James Haddock; Nicola Johnson; Sian M Cooper; Elton R Stephens; Russell Cox; John Crosby; Christine L Willis; Thomas J Simpson; Christopher M Thomas
Mutational analysis reveals that all tailoring region genes are required for production of polyketide antibiotic mupirocin by pseudomonas fluorescens: pseudomonic acid B biosynthesis precedes pseudomonic acid A.
The Journal of biological chemistry 2007;282(21):15451-61.
2006: Christopher Arthur; Anna E Szafranska; Jed Long; Jane Mills; Russell Cox; Stuart C Findlow; Thomas J Simpson; Matthew Crump; John Crosby
The malonyl transferase activity of type II polyketide synthase acyl carrier proteins.
Chemistry & biology 2006;13(6):587-96.
2005: Christopher Arthur; Anna E Szafranska; Simon E Evans; Stuart C Findlow; Steven G Burston; Philip Owen; Ian Clark-Lewis; Thomas J Simpson; John Crosby; Matthew Crump
Self-malonylation is an intrinsic property of a chemically synthesized type II polyketide synthase acyl carrier protein.
Biochemistry 2005;44(46):15414-21.
2005: Sian M Cooper; Wanpen Laosripaiboon; Ayesha S Rahman; Joanne Hothersall; A Kassem El-Sayed; Christopher J Winfield; John Crosby; Russell Cox; Thomas J Simpson; Christopher M Thomas
Shift to Pseudomonic acid B production in P. fluorescens NCIMB10586 by mutation of mupirocin tailoring genes mupO, mupU, mupV, and macpE.
Chemistry & biology 2005;12(7):825-33.
2005: Alan M Simm; E Joel Loveridge; John Crosby; Matthew B Avison; Timothy R Walsh; Peter M Bennett
Bulgecin A: a novel inhibitor of binuclear metallo-beta-lactamases.
The Biochemical journal 2005;387(Pt 3):585-90.
2005: Sian M Cooper; Russell Cox; John Crosby; Matthew Crump; Joanne Hothersall; Wanpen Laosripaiboon; Thomas J Simpson; Christopher M Thomas
Mupirocin W, a novel pseudomonic acid produced by targeted mutation of the mupirocin biosynthetic gene cluster.
Chemical communications (Cambridge, England) 2005;(9):1179-81.
2005: Ayesha S Rahman; Joanne Hothersall; John Crosby; Thomas J Simpson; Christopher M Thomas
Tandemly duplicated acyl carrier proteins, which increase polyketide antibiotic production, can apparently function either in parallel or in series.
The Journal of biological chemistry 2005;280(8):6399-408.
2004: Christine A Parker; Neil J Anderson; Emma S J Robinson; Rhiannon Price; Robin J Tyacke; Stephen M Husbands; Michael P Dillon; Richard M Eglen; Alan L Hudson; David J Nutt; Matthew Crump; John Crosby
Harmane and harmalan are bioactive components of classical clonidine-displacing substance.
Biochemistry 2004;43(51):16385-92.
2004: Andrea T Hadfield; Claire Limpkin; Watchrra Teartasin; Thomas J Simpson; John Crosby; Matthew Crump
The crystal structure of the actIII actinorhodin polyketide reductase: proposed mechanism for ACP and polyketide binding.
Structure (London, England : 1993) 2004;12(10):1865-75.
2004: Watchrra Teartasin; Claire Limpkin; Frank Glod; James Spencer; Russell Cox; Thomas J Simpson; John Crosby; Matthew Crump; Andrea T Hadfield
Expression, purification and preliminary X-ray diffraction analysis of a ketoreductase from a type II polyketide synthase.
Acta crystallographica. Section D, Biological crystallography 2004;60(Pt 6):1137-8.
2003: Emma S J Robinson; Neil J Anderson; John Crosby; David J Nutt; Alan L Hudson
Endogenous beta-carbolines as clonidine-displacing substances.
Annals of the New York Academy of Sciences 2003;1009():157-66.
2003: Stuart C Findlow; Claire Winsor; Thomas J Simpson; John Crosby; Matthew Crump
Solution structure and dynamics of oxytetracycline polyketide synthase acyl carrier protein from Streptomyces rimosus.
Biochemistry 2003;42(28):8423-33.
2003: Thomas P Nicholson; Christopher J Winfield; James Westcott; John Crosby; Thomas J Simpson; Russell Cox
First in vitro directed biosynthesis of new compounds by a minimal type II polyketide synthase: evidence for the mechanism of chain length determination.
Chemical communications (Cambridge, England) 2003;(6):686-7.
2003: Michelle A Reed; Michael Schweizer; Anna E Szafranska; Christopher Arthur; Thomas P Nicholson; Russell Cox; John Crosby; Matthew Crump; Thomas J Simpson
The type I rat fatty acid synthase ACP shows structural homology and analogous biochemical properties to type II ACPs.
Organic & biomolecular chemistry 2003;1(3):463-71.
2002: Christopher Arthur; Russell Cox; John Crosby; Mujiber M Rahman; Thomas J Simpson; Florilene Soulas; Roberto Spogli; Anna E Szafranska; James Westcott; Christopher J Winfield
Synthesis and characterisation of acyl carrier protein bound polyketide analogues.
Chembiochem : a European journal of chemical biology 2002;3(2-3):253-7.
2002: Anna E Szafranska; Timothy S Hitchman; Russell Cox; John Crosby; Thomas J Simpson
Kinetic and mechanistic analysis of the malonyl CoA:ACP transacylase from Streptomyces coelicolor indicates a single catalytically competent serine nucleophile at the active site.
Biochemistry 2002;41(5):1421-7.
2001: Stephen M Husbands; R A Glennon; S Gorgerat; R Gough; Robin J Tyacke; John Crosby; David J Nutt; John W Lewis; Alan L Hudson
beta-carboline binding to imidazoline receptors.
Drug and alcohol dependence 2001;64(2):203-8.
2001: B G McIntyre; F Martínez Bermejo; S K Srivastava; Stephen M Husbands; J W Lewis; John Crosby; Thomas J Simpson
Solid phase synthesis of 4-hydroxycinnamic acid and its derivatives for potential use in combinatorial chemistry: a novel route for the synthesis of 4-hydroxycinnamoyl coenzyme A and NMDA receptor antagonists.
Combinatorial chemistry & high throughput screening 2001;4(1):111-4.
2000: Christine A Parker; Alan L Hudson; David J Nutt; Michael P Dillon; Richard M Eglen; John Crosby
Isolation of RP-HPLC pure clonidine-displacing substance from NG108-15 cells.
European journal of pharmacology 2000;387(1):27-30.
1999: Christian P Bisang; Paul F Long; Jesús Cortés; James Westcott; John Crosby; Anne-Lise Matharu; Russell Cox; Thomas J Simpson; James Staunton; Peter F Leadlay
A chain initiation factor common to both modular and aromatic polyketide synthases.
Nature 1999;401(6752):502-5.
1999: Christine A Parker; Alan L Hudson; David J Nutt; Michael P Dillon; Richard M Eglen; S L Chan; Noel G Morgan; John Crosby
Extraction of active clonidine-displacing substance from bovine lung and comparison with clonidine-displacing substance extracted from other tissues.
European journal of pharmacology 1999;378(2):213-21.
1999: Christine A Parker; Alan L Hudson; David J Nutt; Michael P Dillon; Richard M Eglen; John Crosby
Comparison of crude methanolic CDS extracts from various tissues.
Annals of the New York Academy of Sciences 1999;881():92-6.
1998: Anne-Lise Matharu; Russell Cox; John Crosby; KJ Byrom; Thomas J Simpson
MCAT is not required for in vitro polyketide synthesis in a minimal actinorhodin polyketide synthase from Streptomyces coelicolor.
Chemistry & biology 1998;5(12):699-711.
1998: John Crosby; KJ Byrom; Timothy S Hitchman; Russell Cox; Matthew Crump; I S Findlow; M J Bibb; Thomas J Simpson
Acylation of Streptomyces type II polyketide synthase acyl carrier proteins.
FEBS letters 1998;433(1-2):132-8.
1998: Timothy S Hitchman; John Crosby; KJ Byrom; Russell Cox; Thomas J Simpson
Catalytic self-acylation of type II polyketide synthase acyl carrier proteins.
Chemistry & biology 1998;5(1):35-47.
1997: Matthew Crump; John Crosby; Christopher E Dempsey; J A Parkinson; M Murray; David A Hopwood; Thomas J Simpson
Solution structure of the actinorhodin polyketide synthase acyl carrier protein from Streptomyces coelicolor A3(2).
Biochemistry 1997;36(20):6000-8.
1997: Russell Cox; Timothy S Hitchman; KJ Byrom; I S Findlow; Julian Tanner; John Crosby; Thomas J Simpson
Post-translational modification of heterologously expressed Streptomyces type II polyketide synthase acyl carrier proteins.
FEBS letters 1997;405(3):267-72.
1996: Matthew Crump; John Crosby; Christopher E Dempsey; M Murray; David A Hopwood; Thomas J Simpson
Conserved secondary structure in the actinorhodin polyketide synthase acyl carrier protein from Streptomyces coelicolor A3(2) and the fatty acid synthase acyl carrier protein from Escherichia coli.
FEBS letters 1996;391(3):302-6.
1995: John Crosby; David H Sherman; Maureen J Bibb; W Peter Revill; David A Hopwood; Thomas J Simpson
Polyketide synthase acyl carrier proteins from Streptomyces: expression in Escherichia coli, purification and partial characterisation.
Biochimica et biophysica acta 1995;1251(1):32-42.