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Timothy Cross

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Huan-Xiang Zhou; Timothy A Cross
Modeling the membrane environment has implications for membrane protein structure and function: influenza A M2 protein.
Juan Du; Timothy A Cross; Huan-Xiang Zhou
Recent progress in structure-based anti-influenza drug design.
Yimin Miao; Huajun Qin; Mukesh Sharma; William W Brey; Thach V Can; Riqiang Fu; Peter L Gor'kov; Ivan Hung; Sorin Luca; Timothy A Cross
M2 proton channel structural validation from full-length protein samples in synthetic bilayers and E. coli membranes.

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2013: Huan-Xiang Zhou; Timothy A Cross
Modeling the membrane environment has implications for membrane protein structure and function: influenza A M2 protein.
Protein science : a publication of the Protein Society 2013;22(4):381-94.
2012: Juan Du; Timothy A Cross; Huan-Xiang Zhou
Recent progress in structure-based anti-influenza drug design.
Drug discovery today 2012;17(19-20):1111-20.
2012: Yimin Miao; Huajun Qin; Mukesh Sharma; William W Brey; Thach V Can; Riqiang Fu; Peter L Gor'kov; Ivan Hung; Sorin Luca; Timothy A Cross
M2 proton channel structural validation from full-length protein samples in synthetic bilayers and E. coli membranes.
Angewandte Chemie (International ed. in English) 2012;51(33):8383-6.
2012: Hao Dong; Mukesh Sharma; Huan-Xiang Zhou; Timothy A Cross
Glycines: role in α-helical membrane protein structures and a potential indicator of native conformation.
Biochemistry 2012;51(24):4779-89.
2012: Thach V Can; Peter L Gor'kov; Ivan Hung; Mukesh Sharma; William W Brey; Timothy A Cross
Magic angle spinning and oriented sample solid-state NMR structural restraints combine for influenza a M2 protein functional insights.
Journal of the American Chemical Society 2012;134(22):9022-5.
2012: Timothy A Cross; Hao Dong; Mukesh Sharma; David D Busath; Huan-Xiang Zhou
M2 protein from influenza A: from multiple structures to biophysical and functional insights.
Current opinion in virology 2012;2(2):128-33.
2011: Jian Hu; Huajun Qin; Fei Philip Gao; Timothy A Cross
A systematic assessment of mature MBP in membrane protein production: overexpression, membrane targeting and purification.
Protein expression and purification 2011;80(1):34-40.
2011: Dylan T Murray; Yuanting Lu; Timothy A Cross; Jack R Quine
Geometry of kinked protein helices from NMR data.
Journal of magnetic resonance (San Diego, Calif. : 1997) 2011;210(1):82-9.
2011: Emily Peterson; Ted Ryser; Spencer Funk; Daniel Inouye; Mukesh Sharma; Huajun Qin; Timothy A Cross; David D Busath
Functional reconstitution of influenza A M2(22-62).
Biochimica et biophysica acta 2011;1808(2):516-21.
2011: Timothy A Cross; Mukesh Sharma; Myunggi Yi; Huan-Xiang Zhou
Influence of solubilizing environments on membrane protein structures.
Trends in biochemical sciences 2011;36(2):117-25.
2011: Mukesh Sharma; Conggang Li; David D Busath; Huan-Xiang Zhou; Timothy A Cross
Drug sensitivity, drug-resistant mutations, and structures of three conductance domains of viral porins.
Biochimica et biophysica acta 2011;1808(2):538-46.
2010: Mukesh Sharma; Myunggi Yi; Hao Dong; Huajun Qin; Emily Peterson; David D Busath; Huan-Xiang Zhou; Timothy A Cross
Insight into the mechanism of the influenza A proton channel from a structure in a lipid bilayer.
Science (New York, N.Y.) 2010;330(6003):509-12.
2009: Timothy A Cross
Flu BM2 structure and function.
Nature structural & molecular biology 2009;16(12):1207-9.
2009: Myunggi Yi; Timothy A Cross; Huan-Xiang Zhou
Conformational heterogeneity of the M2 proton channel and a structural model for channel activation.
Proceedings of the National Academy of Sciences of the United States of America 2009;106(32):13311-6.
2009: Jian Hu; Mukesh Sharma; Huajun Qin; Fei Philip Gao; Timothy A Cross
Ligand binding in the conserved interhelical loop of CorA, a magnesium transporter from Mycobacterium tuberculosis.
The Journal of biological chemistry 2009;284(23):15619-28.
2009: Richard C Page; Sangwon Lee; Jacob D Moore; Stanley J Opella; Timothy A Cross
Backbone structure of a small helical integral membrane protein: A unique structural characterization.
Protein science : a publication of the Protein Society 2009;18(1):134-46.
2009: Chunqi Qian; Riqiang Fu; Peter L Gor'kov; William W Brey; Timothy A Cross; Zhehong Gan
14N Polarization Inversion Spin Exchange at Magic Angle (PISEMA).
Journal of magnetic resonance (San Diego, Calif. : 1997) 2009;196(1):96-9.
2008: Hau B Nguyen; Timothy A Cross
1H, 15N and 13C backbone resonance assignment of Rv1567c, an integral membrane protein from Mycobacterium tuberculosis.
Biomolecular NMR assignments 2008;2(1):47-9.
2008: Richard C Page; Sanguk Kim; Timothy A Cross
Transmembrane helix uniformity examined by spectral mapping of torsion angles.
Structure (London, England : 1993) 2008;16(5):787-97.
2008: Jian Hu; Huajun Qin; Mukesh Sharma; Timothy A Cross; Fei Philip Gao
Chemical cleavage of fusion proteins for high-level production of transmembrane peptides and protein domains containing conserved methionines.
Biochimica et biophysica acta 2008;1778(4):1060-6.
2008: Srisairam Achuthan; Tom Asbury; Jun Hu; Richard Bertram; Timothy A Cross; Jack R Quine
Continuity conditions and torsion angles from ssNMR orientational restraints.
Journal of magnetic resonance (San Diego, Calif. : 1997) 2008;191(1):24-30.
2008: Conggang Li; Myunggi Yi; Jun Hu; Huan-Xiang Zhou; Timothy A Cross
Solid-state NMR and MD simulations of the antiviral drug amantadine solubilized in DMPC bilayers.
Biophysical journal 2008;94(4):1295-302.
2008: J Craig Moffat; Viksita Vijayvergiya; Philip Fei Gao; Timothy A Cross; Dixon J Woodbury; David D Busath
Proton transport through influenza A virus M2 protein reconstituted in vesicles.
Biophysical journal 2008;94(2):434-45.
2008: Huajun Qin; Jian Hu; Yuanzhi Hua; Shridhar V Challa; Timothy A Cross; Fei P Gao
Construction of a series of vectors for high throughput cloning and expression screening of membrane proteins from Mycobacterium tuberculosis.
BMC biotechnology 2008;8():51.
2007: Richard C Page; Fei Philip Gao; Jian Hu; Conggang Li; Timothy A Cross
Lipid bilayers: an essential environment for the understanding of membrane proteins.
Magnetic resonance in chemistry : MRC 2007;45 Suppl 1():S2-11.
2007: Conggang Li; Huajun Qin; Fei Philip Gao; Timothy A Cross
Solid-state NMR characterization of conformational plasticity within the transmembrane domain of the influenza A M2 proton channel.
Biochimica et biophysica acta 2007;1768(12):3162-70.
2007: Jian Hu; Huajun Qin; Conggang Li; Mukesh Sharma; Timothy A Cross; Fei Philip Gao
Structural biology of transmembrane domains: efficient production and characterization of transmembrane peptides by NMR.
Protein science : a publication of the Protein Society 2007;16(10):2153-65.
2007: Riqiang Fu; Milton Truong; Randy J Saager; Myriam Cotten; Timothy A Cross
High-resolution heteronuclear correlation spectroscopy in solid state NMR of aligned samples.
Journal of magnetic resonance (San Diego, Calif. : 1997) 2007;188(1):41-8.
2007: Jun Hu; Riqiang Fu; Timothy A Cross
The chemical and dynamical influence of the anti-viral drug amantadine on the M2 proton channel transmembrane domain.
Biophysical journal 2007;93(1):276-83.
2007: Jun Hu; Tom Asbury; Srisairam Achuthan; Conggang Li; Richard Bertram; Jack R Quine; Riqiang Fu; Timothy A Cross
Backbone structure of the amantadine-blocked trans-membrane domain M2 proton channel from Influenza A virus.
Biophysical journal 2007;92(12):4335-43.
2007: Conggang Li; Philip Gao; Huajun Qin; Rose Chase; Peter L Gor'kov; William W Brey; Timothy A Cross
Uniformly aligned full-length membrane proteins in liquid crystalline bilayers for structural characterization.
Journal of the American Chemical Society 2007;129(17):5304-5.
2006: Tom Asbury; Jack R Quine; Srisairam Achuthan; Jun Hu; Michael S Chapman; Timothy A Cross; Richard Bertram
PIPATH: an optimized algorithm for generating alpha-helical structures from PISEMA data.
Journal of magnetic resonance (San Diego, Calif. : 1997) 2006;183(1):87-95.
2006: Eduard Y Chekmenev; Peter L Gor'kov; Timothy A Cross; Ali M Alaouie; Alex I Smirnov
Flow-through lipid nanotube arrays for structure-function studies of membrane proteins by solid-state NMR spectroscopy.
Biophysical journal 2006;91(8):3076-84.
2006: Eduard Y Chekmenev; Kevin W Waddell; Jun Hu; Zhehong Gan; Richard J Wittebort; Timothy A Cross
Ion-binding study by 17O solid-state NMR spectroscopy in the model peptide Gly-Gly-Gly at 19.6 T.
Journal of the American Chemical Society 2006;128(30):9849-55.
2006: Peter L Gor'kov; Eduard Y Chekmenev; Riqiang Fu; Jun Hu; Timothy A Cross; Myriam Cotten; William W Brey
A large volume flat coil probe for oriented membrane proteins.
Journal of magnetic resonance (San Diego, Calif. : 1997) 2006;181(1):9-20.
2006: Jun Hu; Riqiang Fu; Katsuyuki Nishimura; Li Zhang; Huan-Xiang Zhou; David D Busath; Viksita Vijayvergiya; Timothy A Cross
Histidines, heart of the hydrogen ion channel from influenza A virus: toward an understanding of conductance and proton selectivity.
Proceedings of the National Academy of Sciences of the United States of America 2006;103(18):6865-70.
2006: Conggang Li; Yiming Mo; Jun Hu; Eduard Y Chekmenev; Changlin Tian; Fei Philip Gao; Riqiang Fu; Peter L Gor'kov; William W Brey; Timothy A Cross
Analysis of RF heating and sample stability in aligned static solid-state NMR spectroscopy.
Journal of magnetic resonance (San Diego, Calif. : 1997) 2006;180(1):51-7.
2006: Jack R Quine; Srisairam Achuthan; Tom Asbury; Richard Bertram; Michael S Chapman; Jun Hu; Timothy A Cross
Intensity and mosaic spread analysis from PISEMA tensors in solid-state NMR.
Journal of magnetic resonance (San Diego, Calif. : 1997) 2006;179(2):190-8.
2006: Richard C Page; Jacob D Moore; Hau B Nguyen; Mukesh Sharma; Rose Chase; Fei Philip Gao; Charles K Mobley; Charles R Sanders; Liping Ma; Frank D Sönnichsen; Sangwon Lee; Stanley C Howell; Stanley J Opella; Timothy A Cross
Comprehensive evaluation of solution nuclear magnetic resonance spectroscopy sample preparation for helical integral membrane proteins.
Journal of structural and functional genomics 2006;7(1):51-64.
2005: Riqiang Fu; William W Brey; K Shetty; Peter L Gor'kov; Saikat Saha; J R Long; S C Grant; Eduard Y Chekmenev; Jun Hu; Zhehong Gan; Mukesh Sharma; F Zhang; T M Logan; R Brüschweller; Arthur S Edison; A Blue; I R Dixon; W D Markiewicz; Timothy A Cross
Ultra-wide bore 900 MHz high-resolution NMR at the National High Magnetic Field Laboratory.
Journal of magnetic resonance (San Diego, Calif. : 1997) 2005;177(1):1-8.
2005: Jun Hu; Eduard Y Chekmenev; Zhehong Gan; Peter L Gor'kov; Saikat Saha; William W Brey; Timothy A Cross
Ion solvation by channel carbonyls characterized by 17O solid-state NMR at 21 T.
Journal of the American Chemical Society 2005;127(34):11922-3.
2005: Ying Xiong; Michael J Chalmers; Fei Philip Gao; Timothy A Cross; Alan G Marshall
Identification of Mycobacterium tuberculosis H37Rv integral membrane proteins by one-dimensional gel electrophoresis and liquid chromatography electrospray ionization tandem mass spectrometry.
Journal of proteome research 2005;4(3):855-61.
2005: Eduard Y Chekmenev; Jun Hu; Peter L Gor'kov; William W Brey; Timothy A Cross; Andres Ruuge; Alex I Smirnov
15N and 31P solid-state NMR study of transmembrane domain alignment of M2 protein of influenza A virus in hydrated cylindrical lipid bilayers confined to anodic aluminum oxide nanopores.
Journal of magnetic resonance (San Diego, Calif. : 1997) 2005;173(2):322-7.
2005: Fei Philip Gao; Timothy A Cross
Recent developments in membrane-protein structural genomics.
Genome biology 2005;6(13):244.
2005: Alla Korepanova; Fei P Gao; Yuanzi Hua; Huajun Qin; Robert K Nakamoto; Timothy A Cross
Cloning and expression of multiple integral membrane proteins from Mycobacterium tuberculosis in Escherichia coli.
Protein science : a publication of the Protein Society 2005;14(1):148-58.
2004: Jack R Quine; Timothy A Cross; Michael S Chapman; Richard Bertram
Mathematical aspects of protein structure determination with NMR orientational restraints.
Bulletin of mathematical biology 2004;66(6):1705-30.
2004: Viksita Vijayvergiya; Ryan Wilson; Adam Chorak; Philip Fei Gao; Timothy A Cross; David D Busath
Proton conductance of influenza virus M2 protein in planar lipid bilayers.
Biophysical journal 2004;87(3):1697-704.
2004: Sanguk Kim; Timothy A Cross
2D solid state NMR spectral simulation of 3(10), alpha, and pi-helices.
Journal of magnetic resonance (San Diego, Calif. : 1997) 2004;168(2):187-93.
2004: Y Mo; Timothy A Cross; Willy Nerdal
Structural restraints and heterogeneous orientation of the gramicidin A channel closed state in lipid bilayers.
Biophysical journal 2004;86(5):2837-45.
2004: Hyeongnam Kim; Timothy A Cross; Riqiang Fu
Cross-polarization schemes for peptide samples oriented in hydrated phospholipid bilayers.
Journal of magnetic resonance (San Diego, Calif. : 1997) 2004;168(1):147-52.
2004: Riqiang Fu; Jun Hu; Timothy A Cross
Towards quantitative measurements in solid-state CPMAS NMR: A Lee-Goldburg frequency modulated cross-polarization scheme.
Journal of magnetic resonance (San Diego, Calif. : 1997) 2004;168(1):8-17.
2003: Changlin Tian; Philip Fei Gao; Lawrence H Pinto; Robert A Lamb; Timothy A Cross
Initial structural and dynamic characterization of the M2 protein transmembrane and amphipathic helices in lipid bilayers.
Protein science : a publication of the Protein Society 2003;12(11):2597-605.
2003: Richard Bertram; Tom Asbury; Felcy Fabiola; Jack R Quine; Timothy A Cross; Michael S Chapman
Atomic refinement with correlated solid-state NMR restraints.
Journal of magnetic resonance (San Diego, Calif. : 1997) 2003;163(2):300-9.
2003: Nathan C Bingham; Natasha E C Smith; Timothy A Cross; David D Busath
Molecular dynamics simulations of Trp side-chain conformational flexibility in the gramicidin A channel.
Biopolymers 2003;71(5):593-600.
2002: Riqiang Fu; Changlin Tian; Hyeongnam Kim; Scott A Smith; Timothy A Cross
The effect of Hartmann-Hahn mismatching on polarization inversion spin exchange at the magic angle.
Journal of magnetic resonance (San Diego, Calif. : 1997) 2002;159(2):167-74.
2002: Katsuyuki Nishimura; Sanguk Kim; Li Zhang; Timothy A Cross
The closed state of a H+ channel helical bundle combining precise orientational and distance restraints from solid state NMR.
Biochemistry 2002;41(44):13170-7.
2002: Sanguk Kim; Timothy A Cross
Uniformity, ideality, and hydrogen bonds in transmembrane alpha-helices.
Biophysical journal 2002;83(4):2084-95.
2002: Chad D Cole; Adam S Frost; Nephi Thompson; Myriam Cotten; Timothy A Cross; David D Busath
Noncontact dipole effects on channel permeation. VI. 5F- and 6F-Trp gramicidin channel currents.
Biophysical journal 2002;83(4):1974-86.
2002: Changlin Tian; Kurt Tobler; Robert A Lamb; Lawrence H Pinto; Timothy A Cross
Expression and initial structural insights from solid-state NMR of the M2 proton channel from influenza A virus.
Biochemistry 2002;41(37):11294-300.
2002: Joseph A Gowen; Jeffrey C Markham; Sara E Morrison; Timothy A Cross; David D Busath; Eric J Mapes; Mark F Schumaker
The role of Trp side chains in tuning single proton conduction through gramicidin channels.
Biophysical journal 2002;83(2):880-98.
2002: Zhehong Gan; Peter L Gor'kov; Timothy A Cross; Ago Samoson; Dominique Massiot
Seeking higher resolution and sensitivity for NMR of quadrupolar nuclei at ultrahigh magnetic fields.
Journal of the American Chemical Society 2002;124(20):5634-5.
2002: Riqiang Fu; Changlin Tian; Timothy A Cross
NMR spin locking of proton magnetization under a frequency-switched Lee-Goldburg pulse sequence.
Journal of magnetic resonance (San Diego, Calif. : 1997) 2002;154(1):130-5.
2001: J Wang; Sanguk Kim; FA Kovacs; Timothy A Cross
Structure of the transmembrane region of the M2 protein H(+) channel.
Protein science : a publication of the Protein Society 2001;10(11):2241-50.
2001: JK Denny; J Wang; Timothy A Cross; Jack R Quine
PISEMA powder patterns and PISA wheels.
Journal of magnetic resonance (San Diego, Calif. : 1997) 2001;152(2):217-26.
2001: D G Anderson; Randall B Shirts; Timothy A Cross; David D Busath
Noncontact dipole effects on channel permeation. V. Computed potentials for fluorinated gramicidin.
Biophysical journal 2001;81(3):1255-64.
2001: N Thompson; G Thompson; Chad D Cole; Myriam Cotten; Timothy A Cross; David D Busath
Noncontact dipole effects on channel permeation. IV. Kinetic model of 5F-Trp(13) gramicidin A currents.
Biophysical journal 2001;81(3):1245-54.
2001: J C Markham; J A Gowen; Timothy A Cross; David D Busath
Comparison of gramicidin A and gramicidin M channel conductance dispersities.
Biochimica et biophysica acta 2001;1513(2):185-92.
2001: Sanguk Kim; Jack R Quine; Timothy A Cross
Complete cross-validation and R-factor calculation of a solid-state NMR derived structure.
Journal of the American Chemical Society 2001;123(30):7292-8.
2000: Tomas Byström; Erik Strandberg; FA Kovacs; Timothy A Cross; Göran Lindblom
Influence of transmembrane peptides on bilayers of phosphatidylcholines with different acyl chain lengths studied by solid-state NMR.
Biochimica et biophysica acta 2000;1509(1-2):335-45.
2000: Richard Bertram; Jack R Quine; Michael S Chapman; Timothy A Cross
Atomic refinement using orientational restraints from solid-state NMR.
Journal of magnetic resonance (San Diego, Calif. : 1997) 2000;147(1):9-16.
2000: Z Song; FA Kovacs; J Wang; JK Denny; S C Shekar; Jack R Quine; Timothy A Cross
Transmembrane domain of M2 protein from influenza A virus studied by solid-state (15)N polarization inversion spin exchange at magic angle NMR.
Biophysical journal 2000;79(2):767-75.
2000: J Wang; JK Denny; Changlin Tian; Sanguk Kim; Y Mo; FA Kovacs; Z Song; Katsuyuki Nishimura; Zhehong Gan; Riqiang Fu; Jack R Quine; Timothy A Cross
Imaging membrane protein helical wheels.
Journal of magnetic resonance (San Diego, Calif. : 1997) 2000;144(1):162-7.
2000: Riqiang Fu; Myriam Cotten; Timothy A Cross
Inter- and intramolecular distance measurements by solid-state MAS NMR: determination of gramicidin A channel dimer structure in hydrated phospholipid bilayers.
Journal of biomolecular NMR 2000;16(3):261-8.
2000: FA Kovacs; JK Denny; Z Song; Jack R Quine; Timothy A Cross
Helix tilt of the M2 transmembrane peptide from influenza A virus: an intrinsic property.
Journal of molecular biology 2000;295(1):117-25.
1999: L R Phillips; Chad D Cole; R J Hendershot; Myriam Cotten; Timothy A Cross; David D Busath
Noncontact dipole effects on channel permeation. III. Anomalous proton conductance effects in gramicidin.
Biophysical journal 1999;77(5):2492-501.
1999: F Xu; Timothy A Cross
Water: foldase activity in catalyzing polypeptide conformational rearrangements.
Proceedings of the National Academy of Sciences of the United States of America 1999;96(16):9057-61.
1999: F Tian; Riqiang Fu; Timothy A Cross
13C selective polarization and spin diffusion in a lipid bilayer-bound polypeptide by solid-state NMR.
Journal of magnetic resonance (San Diego, Calif. : 1997) 1999;139(2):377-81.
1999: Myriam Cotten; Changlin Tian; David D Busath; Randall B Shirts; Timothy A Cross
Modulating dipoles for structure-function correlations in the gramicidin A channel.
Biochemistry 1999;38(29):9185-97.
1999: FA Kovacs; Jack R Quine; Timothy A Cross
Validation of the single-stranded channel conformation of gramicidin A by solid-state NMR.
Proceedings of the National Academy of Sciences of the United States of America 1999;96(14):7910-5.
1999: Timothy A Cross; A Arseniev; B A Cornell; J H Davis; J Antoinette Killian; Roger E Koeppe; L K Nicholson; Frances Separovic; Bonnie A Wallace
Gramicidin channel controversy--revisited.
Nature structural biology 1999;6(7):610-1; discussion 611-2.
1999: Myriam Cotten; Riqiang Fu; Timothy A Cross
Solid-state NMR and hydrogen-deuterium exchange in a bilayer-solubilized peptide: structural and mechanistic implications.
Biophysical journal 1999;76(3):1179-89.
1999: F Tian; Timothy A Cross
Cation transport: an example of structural based selectivity.
Journal of molecular biology 1999;285(5):1993-2003.
1999: C M Bauer; Lawrence H Pinto; Timothy A Cross; Robert A Lamb
The influenza virus M2 ion channel protein: probing the structure of the transmembrane domain in intact cells by using engineered disulfide cross-linking.
Virology 1999;254(1):196-209.
1999: Timothy A Cross; F Tian; Myriam Cotten; J Wang; FA Kovacs; Riqiang Fu
Correlations of structure, dynamics and function in the gramicidin channel by solid-state NMR spectroscopy.
Novartis Foundation symposium 1999;225():4-16; discussion 16-22.
1998: F Tian; Timothy A Cross
Cation binding induced changes in 15N CSA in a membrane-bound polypeptide.
Journal of magnetic resonance (San Diego, Calif. : 1997) 1998;135(2):535-40.
1998: David D Busath; Craig D Thulin; R W Hendershot; L R Phillips; Peter J Maughan; Chad D Cole; N C Bingham; S Morrison; L C Baird; R J Hendershot; Myriam Cotten; Timothy A Cross
Noncontact dipole effects on channel permeation. I. Experiments with (5F-indole)Trp13 gramicidin A channels.
Biophysical journal 1998;75(6):2830-44.
1998: F Tian; Z Song; Timothy A Cross
Orientational constraints derived from hydrated powder samples by two-dimensional PISEMA.
Journal of magnetic resonance (San Diego, Calif. : 1997) 1998;135(1):227-31.
1997: R Ketchem; B Roux; Timothy A Cross
High-resolution polypeptide structure in a lamellar phase lipid environment from solid state NMR derived orientational constraints.
Structure (London, England : 1993) 1997;5(12):1655-69.
1997: Myriam Cotten; V G Soghomonian; weidong hu; Timothy A Cross
High resolution and high fields in biological solid state NMR.
Solid state nuclear magnetic resonance 1997;9(1):77-80.
1997: FA Kovacs; Timothy A Cross
Transmembrane four-helix bundle of influenza A M2 protein channel: structural implications from helix tilt and orientation.
Biophysical journal 1997;73(5):2511-7.
1997: Myriam Cotten; F Xu; Timothy A Cross
Protein stability and conformational rearrangements in lipid bilayers: linear gramicidin, a model system.
Biophysical journal 1997;73(2):614-23.
1997: Jack R Quine; M T Brenneman; Timothy A Cross
Protein structural analysis from solid-state NMR-derived orientational constraints.
Biophysical journal 1997;72(5):2342-8.
1997: Timothy A Cross
Solid-state nuclear magnetic resonance characterization of gramicidin channel structure.
Methods in enzymology 1997;289():672-96.
1996: S Huo; S Arumugam; Timothy A Cross
Hydrogen exchange in the lipid bilayer-bound gramicidin channel.
Solid state nuclear magnetic resonance 1996;7(3):177-83.
1996: F Tian; K C Lee; weidong hu; Timothy A Cross
Monovalent cation transport: lack of structural deformation upon cation binding.
Biochemistry 1996;35(37):11959-66.
1996: R R Ketchem; K C Lee; S Huo; Timothy A Cross
Macromolecular structural elucidation with solid-state NMR-derived orientational constraints.
Journal of biomolecular NMR 1996;8(1):1-14.
1996: S Arumugam; S Pascal; C L North; weidong hu; K C Lee; Myriam Cotten; R R Ketchem; F Xu; M Brenneman; FA Kovacs; F Tian; A Wang; S Huo; Timothy A Cross
Conformational trapping in a membrane environment: a regulatory mechanism for protein activity?
Proceedings of the National Academy of Sciences of the United States of America 1996;93(12):5872-6.
1995: weidong hu; Timothy A Cross
Tryptophan hydrogen bonding and electric dipole moments: functional roles in the gramicidin channel and implications for membrane proteins.
Biochemistry 1995;34(43):14147-55.
1995: weidong hu; N D Lazo; Timothy A Cross
Tryptophan dynamics and structural refinement in a lipid bilayer environment: solid state NMR of the gramicidin channel.
Biochemistry 1995;34(43):14138-46.
1995: C L North; Timothy A Cross
Correlations between function and dynamics: time scale coincidence for ion translocation and molecular dynamics in the gramicidin channel backbone.
Biochemistry 1995;34(17):5883-95.
1995: N D Lazo; weidong hu; Timothy A Cross
Low-temperature solid-state 15N NMR characterization of polypeptide backbone librations.
Journal of magnetic resonance. Series B 1995;107(1):43-50.
1995: K C Lee; S Huo; Timothy A Cross
Lipid-peptide interface: valine conformation and dynamics in the gramicidin channel.
Biochemistry 1995;34(3):857-67.
1994: S M Pascal; Timothy A Cross
Polypeptide conformational space. Dynamics by solution NMR disorder by X-ray crystallography.
Journal of molecular biology 1994;241(3):431-9.
1994: R R Ketchem; weidong hu; F Tian; Timothy A Cross
Structure and dynamics from solid state NMR spectroscopy.
Structure (London, England : 1993) 1994;2(8):699-701.
1994: J H Yeo; M Demura; T Asakura; T Fujito; M Imanari; L K Nicholson; Timothy A Cross
Structural analysis of highly oriented poly(p-phenylene-terephthalamide) by 15N solid-state nuclear magnetic resonance.
Solid state nuclear magnetic resonance 1994;3(4):209-18.
1994: K C Lee; Timothy A Cross
Side-chain structure and dynamics at the lipid-protein interface: Val1 of the gramicidin A channel.
Biophysical journal 1994;66(5):1380-7.
1993: N D Lazo; weidong hu; K C Lee; Timothy A Cross
Rapidly-frozen polypeptide samples for characterization of high definition dynamics by solid-state NMR spectroscopy.
Biochemical and biophysical research communications 1993;197(2):904-9.
1993: R R Ketchem; weidong hu; Timothy A Cross
High-resolution conformation of gramicidin A in a lipid bilayer by solid-state NMR.
Science (New York, N.Y.) 1993;261(5127):1457-60.
1993: K C Lee; weidong hu; Timothy A Cross
2H NMR determination of the global correlation time of the gramicidin channel in a lipid bilayer.
Biophysical journal 1993;65(3):1162-7.
1993: S M Pascal; Timothy A Cross
High-resolution structure and dynamic implications for a double-helical gramicidin A conformer.
Journal of biomolecular NMR 1993;3(5):495-513.
1993: weidong hu; K C Lee; Timothy A Cross
Tryptophans in membrane proteins: indole ring orientations and functional implications in the gramicidin channel.
Biochemistry 1993;32(27):7035-47.
1993: L K Nicholson; T Asakura; M Demura; Timothy A Cross
A method for studying the structure of uniaxially aligned biopolymers using solid state 15N-nmr: application to Bombyx mori silk fibroin fibers.
Biopolymers 1993;33(5):847-61.
1993: W Mai; weidong hu; C Wang; Timothy A Cross
Orientational constraints as three-dimensional structural constraints from chemical shift anisotropy: the polypeptide backbone of gramicidin A in a lipid bilayer.
Protein science : a publication of the Protein Society 1993;2(4):532-42.
1993: Timothy A Cross
Anisotropy and NMR of macromolecules.
Biophysical journal 1993;64(2):301-2.
1992: Z Zhang; S M Pascal; Timothy A Cross
A conformational rearrangement in gramicidin A: from a double-stranded left-handed to a single-stranded right-handed helix.
Biochemistry 1992;31(37):8822-8.
1992: S M Pascal; Timothy A Cross
Structure of an isolated gramicidin A double helical species by high-resolution nuclear magnetic resonance.
Journal of molecular biology 1992;226(4):1101-9.
1992: C Wang; Q Teng; Timothy A Cross
Solid-state C NMR spectroscopy of a C carbonyl-labeled polypeptide.
Biophysical journal 1992;61(6):1550-6.
1991: See-Wing Chiu; L K Nicholson; M T Brenneman; Shankar Subramaniam; Q Teng; J A McCammon; Timothy A Cross; Eric Jakobsson
Molecular dynamics computations and solid state nuclear magnetic resonance of the gramicidin cation channel.
Biophysical journal 1991;60(4):974-8.
1991: L K Nicholson; Q Teng; Timothy A Cross
Solid-state nuclear magnetic resonance derived model for dynamics in the polypeptide backbone of the gramicidin A channel.
Journal of molecular biology 1991;218(3):621-37.
1991: Q Teng; L K Nicholson; Timothy A Cross
Experimental determination of torsion angles in the polypeptide backbone of the gramicidin A channel by solid state nuclear magnetic resonance.
Journal of molecular biology 1991;218(3):607-19.
1990: F Moll; Timothy A Cross
Optimizing and characterizing alignment of oriented lipid bilayers containing gramicidin D.
Biophysical journal 1990;57(2):351-62.
1989: L K Nicholson; Timothy A Cross
Gramicidin cation channel: an experimental determination of the right-handed helix sense and verification of beta-type hydrogen bonding.
Biochemistry 1989;28(24):9379-85.
1989: C G Fields; Gregg Fields; R L Noble; Timothy A Cross
Solid phase peptide synthesis of 15N-gramicidins A, B, and C and high performance liquid chromatographic purification.
International journal of peptide and protein research 1989;33(4):298-303.
1988: J A Killian; L K Nicholson; Timothy A Cross
Solid-state 15N-NMR evidence that gramicidin A can adopt two different backbone conformations in dimyristoylphosphatidylcholine model membrane preparations.
Biochimica et biophysica acta 1988;943(3):535-40.
1988: P V LoGrasso; F Moll; Timothy A Cross
Solvent history dependence of gramicidin A conformations in hydrated lipid bilayers.
Biophysical journal 1988;54(2):259-67.
1988: Gregg Fields; C G Fields; J Petefish; H E Van Wart; Timothy A Cross
Solid-phase peptide synthesis and solid-state NMR spectroscopy of [Ala3-15N][Val1]gramicidin A.
Proceedings of the National Academy of Sciences of the United States of America 1988;85(5):1384-8.
1987: L K Nicholson; F Moll; T E Mixon; P V LoGrasso; J C Lay; Timothy A Cross
Solid-state 15N NMR of oriented lipid bilayer bound gramicidin A'.
Biochemistry 1987;26(21):6621-6.