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David Crossman

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Chemicals & Drugs

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Caroline Gray; Andrea Haase; Bernard D Keavney; Julie Lees; Kathryn McMahon; Karen Plant; Henry Roehl; Jovana Serbanovic-Canic; Sara Solaymani-Kohal; Simon Tazzyman; Oliver J Watson; David C Crossman; Marc Dacosta; Paul C Evans; Martin Gering; David Bratt; Timothy J A Chico
Loss of function of parathyroid hormone receptor 1 induces notch-dependent aortic defects during zebrafish vascular development.
Abdul G Hameed; David G Kiely; Nadine D Arnold; J Chamberlain; Simon Cross; David C Crossman; Sarah Dawson; Sheila E Francis; Lu Long; Nicholas W Morrell; Christopher M Newman; Claudia Paiva; Josephine A Pickworth; Lan Zhao; Allan Lawrie
Inhibition of tumor necrosis factor-related apoptosis-inducing ligand (TRAIL) reverses experimental pulmonary hypertension.
Robin Condliffe; David C Crossman; Charles A Elliot; Sheila E Francis; Abdul G Hameed; Kay Hopkinson; David G Kiely; Nicholas W Morrell; Allison C Morton; Christopher M Newman; Joanna Pepke-Zaba; Josephine A Pickworth; Elaine Soon; Jay Suntharaligam; Carmen Treacy; Sara J Walker; Allan Lawrie
Serum osteoprotegerin is increased and predicts survival in idiopathic pulmonary arterial hypertension.

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All Publications

2013: Caroline Gray; Andrea Haase; Bernard D Keavney; Julie Lees; Kathryn McMahon; Karen Plant; Henry Roehl; Jovana Serbanovic-Canic; Sara Solaymani-Kohal; Simon Tazzyman; Oliver J Watson; David C Crossman; Marc Dacosta; Paul C Evans; Martin Gering; David Bratt; Timothy J A Chico
Loss of function of parathyroid hormone receptor 1 induces notch-dependent aortic defects during zebrafish vascular development.
Arteriosclerosis, thrombosis, and vascular biology 2013;33(6):1257-63.
2012: Abdul G Hameed; David G Kiely; Nadine D Arnold; J Chamberlain; Simon Cross; David C Crossman; Sarah Dawson; Sheila E Francis; Lu Long; Nicholas W Morrell; Christopher M Newman; Claudia Paiva; Josephine A Pickworth; Lan Zhao; Allan Lawrie
Inhibition of tumor necrosis factor-related apoptosis-inducing ligand (TRAIL) reverses experimental pulmonary hypertension.
The Journal of experimental medicine 2012;209(11):1919-35.
2012: Robin Condliffe; David C Crossman; Charles A Elliot; Sheila E Francis; Abdul G Hameed; Kay Hopkinson; David G Kiely; Nicholas W Morrell; Allison C Morton; Christopher M Newman; Joanna Pepke-Zaba; Josephine A Pickworth; Elaine Soon; Jay Suntharaligam; Carmen Treacy; Sara J Walker; Allan Lawrie
Serum osteoprotegerin is increased and predicts survival in idiopathic pulmonary arterial hypertension.
Pulmonary circulation 2012;2(1):21-7.
2011: Allan Lawrie; Josephine Pickworth; Nadine Arnold; Janet Chamberlain; David C Crossman; Abdul G Hameed; Kay Hopkinson; Aneurin Kennerley; David G Kiely; Sheila E Francis
Paigen diet-fed apolipoprotein E knockout mice develop severe pulmonary hypertension in an interleukin-1-dependent manner.
The American journal of pathology 2011;179(4):1693-705.
2011: Timothy Ellam; Sheila Francis; Martin Wilkie; J Chamberlain; David C Crossman; Ana Munoz; Timothy J A Chico
Dietary phosphate modulates atherogenesis and insulin resistance in apolipoprotein E knockout mice--brief report.
Arteriosclerosis, thrombosis, and vascular biology 2011;31(9):1988-90.
2011: C Gray; Catherine A Loynes; Moira K B Whyte; David C Crossman; Stephen A Renshaw; Timothy J A Chico
Simultaneous intravital imaging of macrophage and neutrophil behaviour during inflammation using a novel transgenic zebrafish.
Thrombosis and haemostasis 2011;105(5):811-9.
2010: Ana Munoz; Chris Newman; David C Crossman
Cardiovascular disease and bone.
Archives of biochemistry and biophysics 2010;503(1):78-83.
2010: Timothy J A Chico; Marta Milo; David C Crossman
The genetics of cardiovascular disease: new insights from emerging approaches.
The Journal of pathology 2010;220(2):186-97.
2009: Jon R Ward; Sheila E Francis; Luke Marsden; Tesha Suddason; Graham M Lord; Steven K Dower; David C Crossman; Ian Sabroe
A central role for monocytes in Toll-like receptor-mediated activation of the vasculature.
Immunology 2009;128(1):58-68.
2009: Ian M Packham; Caroline Gray; Paul R Heath; Paul G Hellewell; Philip Ingham; David C Crossman; Marta Milo; Timothy J A Chico
Microarray profiling reveals CXCR4a is downregulated by blood flow in vivo and mediates collateral formation in zebrafish embryos.
Physiological genomics 2009;38(3):319-27.
2009: Janet Chamberlain; Sheila Francis; Zoe Brookes; Gary Shaw; Delyth Graham; Nicholas J Alp; Steven Dower; David C Crossman
Interleukin-1 regulates multiple atherogenic mechanisms in response to fat feeding.
PloS one 2009;4(4):e5073.
2008: Katalin Eder; Hongtao Guan; Hye Y Sung; Jon Ward; Adrienn Angyal; Michelle Janas; Gabriella Sarmay; Erno Duda; Martin Turner; Steven K Dower; Sheila E Francis; David C Crossman; Endre Kiss-Toth
Tribbles-2 is a novel regulator of inflammatory activation of monocytes.
International immunology 2008;20(12):1543-50.
2008: Timothy J A Chico; Philip Ingham; David C Crossman
Modeling cardiovascular disease in the zebrafish.
Trends in cardiovascular medicine 2008;18(4):150-5.
2008: Rachael M Dewberry; Andrea R King; David C Crossman; Sheila E Francis
Interleukin-1 receptor antagonist (IL-1ra) modulates endothelial cell proliferation.
FEBS letters 2008;582(6):886-90.
2008: Katalin Eder; Hongtao Guan; Hye-Youn Sung; Sheila E Francis; David C Crossman; Endre Kiss-Toth
LDL uptake by monocytes in response to inflammation is MAPK dependent but independent of tribbles protein expression.
Immunology letters 2008;116(2):178-83.
2008: David C Crossman; Allison C Morton; Julian P Gunn; John P Greenwood; Alistair Hall; Keith A A Fox; Andrew J Lucking; Marcus Flather; Belinda Lees; Claire E Foley
Investigation of the effect of Interleukin-1 receptor antagonist (IL-1ra) on markers of inflammation in non-ST elevation acute coronary syndromes (The MRC-ILA-HEART Study).
Trials 2008;9():8.
2008: Allan Lawrie; Elizabeth Waterman; Mark Southwood; David Evans; Jay Suntharalingam; Sheila Francis; David C Crossman; Peter Croucher; Nicholas Morrell; Christopher Newman
Evidence of a role for osteoprotegerin in the pathogenesis of pulmonary arterial hypertension.
The American journal of pathology 2008;172(1):256-64.
2007: Caroline Gray; Ian M Packham; François Wurmser; Nicholas C Eastley; Paul G Hellewell; Philip Ingham; David C Crossman; Timothy J A Chico
Ischemia is not required for arteriogenesis in zebrafish embryos.
Arteriosclerosis, thrombosis, and vascular biology 2007;27(10):2135-41.
2007: Hye-Youn Sung; Hongtao Guan; Agnes Czibula; Andrea R King; Katalin Eder; Emily Heath; S Kim Suvarna; Steven K Dower; Anthony G Wilson; Sheila E Francis; David C Crossman; Endre Kiss-Toth
Human tribbles-1 controls proliferation and chemotaxis of smooth muscle cells via MAPK signaling pathways.
The Journal of biological chemistry 2007;282(25):18379-87.
2007: Heather Wilson; R W Varcoe; Leanne Stokes; K L Holland; Sheila E Francis; Steven K Dower; Annmarie Surprenant; David C Crossman
P2X receptor characterization and IL-1/IL-1Ra release from human endothelial cells.
British journal of pharmacology 2007;151(1):115-27.
2006: Hye-Youn Sung; Sheila E Francis; David C Crossman; Endre Kiss-Toth
Regulation of expression and signalling modulator function of mammalian tribbles is cell-type specific.
Immunology letters 2006;104(1-2):171-7.
2006: Janet Chamberlain; David Evans; Andrea King; Rachael Dewberry; Steven K Dower; David C Crossman; Sheila Francis
Interleukin-1beta and signaling of interleukin-1 in vascular wall and circulating cells modulates the extent of neointima formation in mice.
The American journal of pathology 2006;168(4):1396-403.
2006: Iona Evans; Steven K Dower; Sheila E Francis; David C Crossman; Heather Wilson
Action of intracellular IL-1Ra (Type 1) is independent of the IL-1 intracellular signalling pathway.
Cytokine 2006;33(5):274-80.
2005: C J Dean; Allison C Morton; ND Arnold; D R Hose; David C Crossman; Julian Gunn
Relative importance of the components of stent geometry to stretch induced in-stent neointima formation.
Heart (British Cardiac Society) 2005;91(12):1603-4.
2005: Allison C Morton; Nadine D Arnold; Julian Gunn; Richard Varcoe; Sheila E Francis; Steven K Dower; David C Crossman
Interleukin-1 receptor antagonist alters the response to vessel wall injury in a porcine coronary artery model.
Cardiovascular research 2005;68(3):493-501.
2005: Gemma Satterthwaite; Sheila E Francis; Kim Suvarna; Stephen Blakemore; Chantelle Ward; Don Wallace; Martin Braddock; David C Crossman
Differential gene expression in coronary arteries from patients presenting with ischemic heart disease: further evidence for the inflammatory basis of atherosclerosis.
American heart journal 2005;150(3):488-99.
2005: Enoch Akowuah; C Gray; Allan Lawrie; Paul J Sheridan; C-H Su; T Bettinger; Axel F Brisken; Julian Gunn; David C Crossman; Sheila E Francis; A H Baker; Christopher M Newman
Ultrasound-mediated delivery of TIMP-3 plasmid DNA into saphenous vein leads to increased lumen size in a porcine interposition graft model.
Gene therapy 2005;12(14):1154-7.
2005: Paul J Sheridan; Allan Lawrie; David C Crossman; Cathy M Holt; Christopher M Newman
VP22-mediated intercellular transport correlates with enhanced biological activity of MybEngrailed but not (HSV-I) thymidine kinase fusion proteins in primary vascular cells following non-viral transfection.
The journal of gene medicine 2005;7(3):375-85.
2005: Kausik K Ray; S Francis; David C Crossman
A potential pharmacogenomic strategy for anticoagulant treatment in non-ST elevation acute coronary syndromes: the role of interleukin-1 receptor antagonist genotype.
Journal of thrombosis and haemostasis : JTH 2005;3(2):287-91.
2004: Kausik K Ray; S Francis; David C Crossman
Measurement of plasma von Willebrand factor in acute coronary syndromes and the influence of ABO blood group status.
Journal of thrombosis and haemostasis : JTH 2004;2(11):2053-4.
2004: Heather Wilson; Sheila E Francis; Steven K Dower; David C Crossman
Secretion of intracellular IL-1 receptor antagonist (type 1) is dependent on P2X7 receptor activation.
Journal of immunology (Baltimore, Md. : 1950) 2004;173(2):1202-8.
2004: Allison C Morton; David C Crossman; Julian Gunn
The influence of physical stent parameters upon restenosis.
Pathologie-biologie 2004;52(4):196-205.
2004: David C Crossman
The pathophysiology of myocardial ischaemia.
Heart (British Cardiac Society) 2004;90(5):576-80.
2004: Allison C Morton; ND Arnold; David C Crossman; Julian Gunn
Response of very small (2 mm) porcine coronary arteries to balloon angioplasty and stent implantation.
Heart (British Cardiac Society) 2004;90(3):324-7.
2003: Allan Lawrie; Axel F Brisken; Sheila E Francis; David H Wyllie; Endre Kiss-Toth; Eva E Qwarnstrom; Steven K Dower; David C Crossman; Christopher M Newman
Ultrasound-enhanced transgene expression in vascular cells is not dependent upon cavitation-induced free radicals.
Ultrasound in medicine & biology 2003;29(10):1453-61.
2003: Andrea R King; Sheila E Francis; Collette J Bridgeman; Helen Bird; Moira K B Whyte; David C Crossman
A role for caspase-1 in serum withdrawal-induced apoptosis of endothelial cells.
Laboratory investigation; a journal of technical methods and pathology 2003;83(10):1497-508.
2003: Julian Gunn; David C Crossman; Ever D Grech; DAVID CUMBERLAND
New developments in percutaneous coronary intervention.
BMJ (Clinical research ed.) 2003;327(7407):150-3.
2003: Rachael M Dewberry; David C Crossman; Sheila E Francis
Interleukin-1 receptor antagonist (IL-1RN) genotype modulates the replicative capacity of human endothelial cells.
Circulation research 2003;92(12):1285-7.
2003: S D Pollard; K Munks; C Wales; David C Crossman; DAVID CUMBERLAND; G D G Oakley; Julian Gunn
Position and Mobilisation Post-Angiography Study (PAMPAS): a comparison of 4.5 hours and 2.5 hours bed rest.
Heart (British Cardiac Society) 2003;89(4):447-8.
2003: Paul J Sheridan; David C Crossman
Diagnosing chronic stable angina.
The Practitioner 2003;247(1644):208-10, 212, 214-5 passim.
2003: Julian Gunn; Allison C Morton; C Wales; Christopher M Newman; David C Crossman; DAVID CUMBERLAND
Drug eluting stents: maximising benefit and minimising cost.
Heart (British Cardiac Society) 2003;89(2):127-31.
2002: Paul J Sheridan; David C Crossman
Critical review of unstable angina and non-ST elevation myocardial infarction.
Postgraduate medical journal 2002;78(926):717-26.
2002: Julian Gunn; ND Arnold; K H Chan; L Shepherd; DAVID CUMBERLAND; David C Crossman
Coronary artery stretch versus deep injury in the development of in-stent neointima.
Heart (British Cardiac Society) 2002;88(4):401-5.
2002: Kausik K Ray; Nicola J Camp; Claire E Bennett; Sheila E Francis; David C Crossman
Genetic variation at the interleukin-1 locus is a determinant of changes in soluble endothelial factors in patients with acute coronary syndromes.
Clinical science (London, England : 1979) 2002;103(3):303-10.
2001: D L Lambert; Nadim Malik; L Shepherd; Julian Gunn; Sheila E Francis; A King; David C Crossman; DAVID CUMBERLAND; Cathy M Holt
Localization of c-Myb and induction of apoptosis by antisense oligonucleotide c-Myb after angioplasty of porcine coronary arteries.
Arteriosclerosis, thrombosis, and vascular biology 2001;21(11):1727-32.
2001: Sheila E Francis; Nicola J Camp; A J Burton; Rachael M Dewberry; Julian Gunn; Amanda Stephens-Lloyd; DAVID CUMBERLAND; Anthony H Gershlick; David C Crossman
Interleukin 1 receptor antagonist gene polymorphism and restenosis after coronary angioplasty.
Heart (British Cardiac Society) 2001;86(3):336-40.
2001: J Chamberlain; Julian Gunn; Sheila E Francis; Cathy M Holt; N D Arnold; DAVID CUMBERLAND; M W Ferguson; David C Crossman
TGFbeta is active, and correlates with activators of TGFbeta, following porcine coronary angioplasty.
Cardiovascular research 2001;50(1):125-36.
2001: Nadim Malik; Julian Gunn; L Shepherd; David C Crossman; DAVID CUMBERLAND; Cathy M Holt
Phosphorylcholine-coated stents in porcine coronary arteries: in vivo assessment of biocompatibility.
The Journal of invasive cardiology 2001;13(3):193-201.
2001: Timothy J A Chico; J Chamberlain; Julian Gunn; ND Arnold; Sherron Bullens; tom gadek; Sheila E Francis; S Bunting; M Horton; L Shepherd; Michael T Lipari; C Quan; J Knolle; Hans Ulrich Stilz; Anusch Peyman; David C Crossman
Effect of selective or combined inhibition of integrins alpha(IIb)beta(3) and alpha(v)beta(3) on thrombosis and neointima after oversized porcine coronary angioplasty.
Circulation 2001;103(8):1135-41.
2000: Allan Lawrie; Axel F Brisken; Sheila E Francis; DAVID CUMBERLAND; David C Crossman; Christopher M Newman
Microbubble-enhanced ultrasound for vascular gene delivery.
Gene therapy 2000;7(23):2023-7.
2000: R Dewberry; H Holden; David C Crossman; Sheila Francis
Interleukin-1 receptor antagonist expression in human endothelial cells and atherosclerosis.
Arteriosclerosis, thrombosis, and vascular biology 2000;20(11):2394-400.
1999: Joseph Galea; J Armstrong; Sheila E Francis; G Cooper; David C Crossman; Cathy M Holt
Alterations in c-fos expression, cell proliferation and apoptosis in pressure distended human saphenous vein.
Cardiovascular research 1999;44(2):436-48.
1999: Timothy J A Chico; David C Crossman
Key developments in unstable angina.
The Practitioner 1999;243(1603):706-9, 712, 714.
1999: Allan Lawrie; Axel F Brisken; Sheila E Francis; D I Tayler; J Chamberlain; David C Crossman; DAVID CUMBERLAND; Christopher M Newman
Ultrasound enhances reporter gene expression after transfection of vascular cells in vitro.
Circulation 1999;99(20):2617-20.
1999: Sheila E Francis; Nicola J Camp; Rachael M Dewberry; Julian Gunn; Petros Syrris; N D Carter; Steve Jeffery; JUAN-CARLOS KASKI; DAVID CUMBERLAND; Gordon W Duff; David C Crossman
Interleukin-1 receptor antagonist gene polymorphism and coronary artery disease.
Circulation 1999;99(7):861-6.
1998: Petros Syrris; Nicholas D Carter; J C Metcalfe; Paul R Kemp; David J Grainger; JUAN-CARLOS KASKI; David C Crossman; Sheila E Francis; J Gunn; Steve Jeffery; Kirsten Heathcote
Transforming growth factor-beta1 gene polymorphisms and coronary artery disease.
Clinical science (London, England : 1979) 1998;95(6):659-67.
1998: N Malik; Julian Gunn; Cathy M Holt; L Shepherd; Sheila E Francis; Christopher M Newman; David C Crossman; DAVID CUMBERLAND
Intravascular stents: a new technique for tissue processing for histology, immunohistochemistry, and transmission electron microscopy.
Heart (British Cardiac Society) 1998;80(5):509-16.
1998: N Malik; Sheila E Francis; Cathy M Holt; Julian Gunn; G L Thomas; L Shepherd; J Chamberlain; Christopher M Newman; DAVID CUMBERLAND; David C Crossman
Apoptosis and cell proliferation after porcine coronary angioplasty.
Circulation 1998;98(16):1657-65.
1998: NM Malik; Petros Syrris; R Schwartzman; JUAN-CARLOS KASKI; David C Crossman; Sheila E Francis; Nicholas D Carter; Steve Jeffery
Methylenetetrahydrofolate reductase polymorphism (C-677T) and coronary artery disease.
Clinical science (London, England : 1979) 1998;95(3):311-5.
1997: J Gunn; Cathy M Holt; Sheila E Francis; L Shepherd; M Grohmann; Christopher M Newman; David C Crossman; DAVID CUMBERLAND
The effect of oligonucleotides to c-myb on vascular smooth muscle cell proliferation and neointima formation after porcine coronary angioplasty.
Circulation research 1997;80(4):520-31.
1997: David C Crossman
The future of the management of ischaemic heart disease.
BMJ (Clinical research ed.) 1997;314(7077):356-9.