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Donghui Cui

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Paul J Coleman; Christopher D Cox; Donghui Cui; Scott M Doran; Steven V Fox; Susan L Garson; Anthony Gotter; Charles M Harrell; George D Hartman; Wei Lemaire; Georgia B McGaughey; Thomayant Prueksaritanont; Duane R Reiss; Richard G Ball; Rodney A Bednar; Michael J Bogusky; Michael J Breslin; Tamara D Cabalu; John D Schreier; Joyce Stellabott; Joanne Stevens; Pamela L Tannenbaum; David B Whitman; Chris Winrow; Steven D Young; John Renger
Discovery of [(2R,5R)-5-{[(5-fluoropyridin-2-yl)oxy]methyl}-2-methylpiperidin-1-yl][5-methyl-2-(pyrimidin-2-yl)phenyl]methanone (MK-6096): a dual orexin receptor antagonist with potent sleep-promoting properties.
Chris Winrow; John D Schreier; Joanne Stevens; Pamela L Tannenbaum; Michael J Breslin; Paul J Coleman; Christopher D Cox; Donghui Cui; Scott M Doran; Steven V Fox; Susan L Garson; Anthony Gotter; Charles M Harrell; Duane R Reiss; John Renger
Pharmacological characterization of MK-6096 - a dual orexin receptor antagonist for insomnia.
Chris Winrow; Anthony Gotter; Christopher D Cox; Scott M Doran; Pamela L Tannenbaum; Michael J Breslin; Susan L Garson; Steven V Fox; Charles M Harrell; Joanne Stevens; Duane R Reiss; Donghui Cui; Paul J Coleman; John Renger
Promotion of sleep by suvorexant-a novel dual orexin receptor antagonist.

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All Publications

2012: Paul J Coleman; Christopher D Cox; Donghui Cui; Scott M Doran; Steven V Fox; Susan L Garson; Anthony Gotter; Charles M Harrell; George D Hartman; Wei Lemaire; Georgia B McGaughey; Thomayant Prueksaritanont; Duane R Reiss; Richard G Ball; Rodney A Bednar; Michael J Bogusky; Michael J Breslin; Tamara D Cabalu; John D Schreier; Joyce Stellabott; Joanne Stevens; Pamela L Tannenbaum; David B Whitman; Chris Winrow; Steven D Young; John Renger
Discovery of [(2R,5R)-5-{[(5-fluoropyridin-2-yl)oxy]methyl}-2-methylpiperidin-1-yl][5-methyl-2-(pyrimidin-2-yl)phenyl]methanone (MK-6096): a dual orexin receptor antagonist with potent sleep-promoting properties.
ChemMedChem 2012;7(3):415-24, 337.
2012: Chris Winrow; John D Schreier; Joanne Stevens; Pamela L Tannenbaum; Michael J Breslin; Paul J Coleman; Christopher D Cox; Donghui Cui; Scott M Doran; Steven V Fox; Susan L Garson; Anthony Gotter; Charles M Harrell; Duane R Reiss; John Renger
Pharmacological characterization of MK-6096 - a dual orexin receptor antagonist for insomnia.
Neuropharmacology 2012;62(2):978-87.
2011: Chris Winrow; Anthony Gotter; Christopher D Cox; Scott M Doran; Pamela L Tannenbaum; Michael J Breslin; Susan L Garson; Steven V Fox; Charles M Harrell; Joanne Stevens; Duane R Reiss; Donghui Cui; Paul J Coleman; John Renger
Promotion of sleep by suvorexant-a novel dual orexin receptor antagonist.
Journal of neurogenetics 2011;25(1-2):52-61.
2007: Kelem Kassahun; Ian McIntosh; Donghui Cui; David Hreniuk; Shelia Merschman; Kenneth C Lasseter; Neal Azrolan; Marian Iwamoto; John A Wagner; Larissa A Wenning
Metabolism and disposition in humans of raltegravir (MK-0518), an anti-AIDS drug targeting the human immunodeficiency virus 1 integrase enzyme.
Drug metabolism and disposition: the biological fate of chemicals 2007;35(9):1657-63.
2007: Bennett Ma; Stacey L Polsky-Fisher; Stanley Vickers; Donghui Cui; A David Rodrigues
Cytochrome P450 3A-dependent metabolism of a potent and selective gamma-aminobutyric acid Aalpha2/3 receptor agonist in vitro: involvement of cytochrome P450 3A5 displaying biphasic kinetics.
Drug metabolism and disposition: the biological fate of chemicals 2007;35(8):1301-7.
2006: Stacey L Polsky-Fisher; Stanley Vickers; Donghui Cui; Raju Subramanian; Byron H Arison; Nancy G B Agrawal; Thanh V Goel; Laura K Vessey; M Gail Murphy; Kenneth C Lasseter; Richard C Simpson; Jose M Vega; A David Rodrigues
Metabolism and disposition of a potent and selective GABA-Aalpha2/3 receptor agonist in healthy male volunteers.
Drug metabolism and disposition: the biological fate of chemicals 2006;34(6):1004-11.
2004: Michael L Schrag; Donghui Cui; Thomas H Rushmore; Magang Shou; Bennett Ma; A David Rodrigues
Sulfotransferase 1E1 is a low km isoform mediating the 3-O-sulfation of ethinyl estradiol.
Drug metabolism and disposition: the biological fate of chemicals 2004;32(11):1299-303.
2004: Donghui Cui; Catherine Booth-Genthe; Edward J Carlini; Brian Carr; Michael L Schrag
Heterotropic modulation of sulfotransferase 2A1 activity by celecoxib: product ratio switching of ethynylestradiol sulfation.
Drug metabolism and disposition: the biological fate of chemicals 2004;32(11):1260-4.
2004: Donghui Cui; Raju Subramanian; Magang Shou; Xiao Yu; Michael A Wallace; Matthew P Braun; Byron H Arison; James A Yergey; Thomayant Prueksaritanont
In vitro and in vivo metabolism of a potent and selective integrin alpha v beta 3 antagonist in rats, dogs, and monkeys.
Drug metabolism and disposition: the biological fate of chemicals 2004;32(8):848-61.
2003: Donald E Slaughter; Norihiro Takenaga; Ping Lu; Carol Assang; Deborah J Walsh; Byron H Arison; Donghui Cui; Rita A Halpin; Leslie A Geer; Kamlesh P Vyas; Thomas A Baillie
Metabolism of rofecoxib in vitro using human liver subcellular fractions.
Drug metabolism and disposition: the biological fate of chemicals 2003;31(11):1398-408.
2003: A David Rodrigues; Rita A Halpin; Leslie A Geer; Donghui Cui; Eric J Woolf; Catherine Z Matthews; Keith M Gottesdiener; Patrick J Larson; Kenneth C Lasseter; Nancy G B Agrawal
Absorption, metabolism, and excretion of etoricoxib, a potent and selective cyclooxygenase-2 inhibitor, in healthy male volunteers.
Drug metabolism and disposition: the biological fate of chemicals 2003;31(2):224-32.
2002: Rita A Halpin; Arturo G Porras; Leslie A Geer; Margaret R Davis; Donghui Cui; George A Doss; Eric J Woolf; Donald G Musson; Catherine Matthews; Ralph S Mazenko; Jules I Schwartz; Kenneth C Lasseter; Kamlesh P Vyas; Thomas A Baillie
The disposition and metabolism of rofecoxib, a potent and selective cyclooxygenase-2 inhibitor, in human subjects.
Drug metabolism and disposition: the biological fate of chemicals 2002;30(6):684-93.
2001: Magang Shou; Y Lin; P Lu; Cuyue Tang; Qin Mei; Donghui Cui; Wei Tang; Jason S Ngui; C C Lin; Rominder Singh; Bradley K Wong; J A Yergey; Jiunn H Lin; Paul G Pearson; Thomas A Baillie; A David Rodrigues; Thomas H Rushmore
Enzyme kinetics of cytochrome P450-mediated reactions.
Current drug metabolism 2001;2(1):17-36.
2000: Suresh K Balani; Xin Xu; Byron H Arison; M V Silva; A Gries; Florencia deLuna; Donghui Cui; Prasad H Kari; T Ly; Cornelis E C A Hop; Rominder Singh; Michael A Wallace; Dennis C Dean; Jiunn H Lin; Paul G Pearson; Thomas A Baillie
Metabolites of caspofungin acetate, a potent antifungal agent, in human plasma and urine.
Drug metabolism and disposition: the biological fate of chemicals 2000;28(11):1274-8.
1999: Stanley Vickers; A D Theoharides; Byron H Arison; Suresh K Balani; Donghui Cui; C A Duncan; Joan D Ellis; LM Gorham; S L Polsky; Thomayant Prueksaritanont; Harri G Ramjit; Donald E Slaughter; Kamlesh P Vyas
In vitro and in vivo studies on the metabolism of tirofiban.
Drug metabolism and disposition: the biological fate of chemicals 1999;27(11):1360-6.
1999: X Yu; Donghui Cui; Margaret R Davis
Identification of in vitro metabolites of Indinavir by "intelligent automated LC-MS/MS" (INTAMS) utilizing triple quadrupole tandem mass spectrometry.
Journal of the American Society for Mass Spectrometry 1999;10(2):175-83.