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Bryan Cullen

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Bryan R Cullen
Making a NeST for a persistent virus.
Bryan R Cullen
MicroRNAs as mediators of viral evasion of the immune system.
Adam W Whisnant; Hal P Bogerd; Chin-Ho Chen; Omar Flores; Phong Ho; Jason G Powers; Natalia Sharova; Mario Stevenson; Bryan R Cullen
In-Depth Analysis of the Interaction of HIV-1 with Cellular microRNA Biogenesis and Effector Mechanisms.

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All Publications

2013: Bryan R Cullen
Making a NeST for a persistent virus.
Cell host & microbe 2013;13(3):241-2.
2013: Bryan R Cullen
MicroRNAs as mediators of viral evasion of the immune system.
Nature immunology 2013;14(3):205-10.
2013: Adam W Whisnant; Hal P Bogerd; Chin-Ho Chen; Omar Flores; Phong Ho; Jason G Powers; Natalia Sharova; Mario Stevenson; Bryan R Cullen
In-Depth Analysis of the Interaction of HIV-1 with Cellular microRNA Biogenesis and Effector Mechanisms.
mBio 2013;4(2):.
2012: Bryan R Cullen
MicroRNA expression by an oncogenic retrovirus.
Proceedings of the National Academy of Sciences of the United States of America 2012;109(8):2695-6.
2012: Rebecca L Skalsky; Thomas Tuschl; David L Corcoran; Henri-Jacques Delecluse; Regina Feederle; Christopher L Frank; Eva Gottwein; Markus Hafner; Dong Kang; Micah Luftig; Jeffrey D Nusbaum; Uwe Ohler; Bryan R Cullen
The viral and cellular microRNA targetome in lymphoblastoid cell lines.
PLoS pathogens 2012;8(1):e1002484.
2011: Eva Gottwein; Markus Hafner; Cassandra L Love; Neelanjan Mukherjee; Jeffrey D Nusbaum; Uwe Ohler; Priscilla Shamulailatpam; Rebecca L Skalsky; Thomas Tuschl; David L Corcoran; Sandeep S Dave; Bryan R Cullen
Viral microRNA targetome of KSHV-infected primary effusion lymphoma cell lines.
Cell host & microbe 2011;10(5):515-26.
2011: Bryan R Cullen
Viruses and microRNAs: RISCy interactions with serious consequences.
Genes & development 2011;25(18):1881-94.
2011: Bryan R Cullen
Herpesvirus microRNAs: phenotypes and functions.
Current opinion in virology 2011;1(3):211-5.
2011: Hal P Bogerd; Fengwen Zhang; Paul D Bieniasz; Bryan R Cullen
Human APOBEC3 proteins can inhibit xenotropic murine leukemia virus-related virus infectivity.
Virology 2011;410(1):234-9.
2011: Rebecca L Skalsky; Bryan R Cullen
Reduced expression of brain-enriched microRNAs in glioblastomas permits targeted regulation of a cell death gene.
PloS one 2011;6(9):e24248.
2010: Sarah D Linnstaedt; Eva Gottwein; Rebecca L Skalsky; Micah Luftig; Bryan R Cullen
Virally induced cellular microRNA miR-155 plays a key role in B-cell immortalization by Epstein-Barr virus.
Journal of virology 2010;84(22):11670-8.
2010: Jennifer L Umbach; Lisa I Strelow; Scott W Wong; Bryan R Cullen
Analysis of rhesus rhadinovirus microRNAs expressed in virus-induced tumors from infected rhesus macaques.
Virology 2010;405(2):592-9.
2010: Bryan R Cullen
Five questions about viruses and microRNAs.
PLoS pathogens 2010;6(2):e1000787.
2010: Hal P Bogerd; Heather W Karnowski; Xuezhong Cai; Jinwook Shin; Michael Pohlers; Bryan R Cullen
A mammalian herpesvirus uses noncanonical expression and processing mechanisms to generate viral MicroRNAs.
Molecular cell 2010;37(1):135-42.
2010: Rebecca L Skalsky; Bryan R Cullen
Viruses, microRNAs, and host interactions.
Annual review of microbiology 2010;64():123-41.
2010: Rebecca L Skalsky; Dana L Vanlandingham; Frank Scholle; Stephen Higgs; Bryan R Cullen
Identification of microRNAs expressed in two mosquito vectors, Aedes albopictus and Culex quinquefasciatus.
BMC genomics 2010;11():119.
2010: Jennifer L Umbach; Kening Wang; Shuang Tang; Philip R Krause; Erik K Mont; Jeffrey I Cohen; Bryan R Cullen
Identification of viral microRNAs expressed in human sacral ganglia latently infected with herpes simplex virus 2.
Journal of virology 2010;84(2):1189-92.
2010: Jennifer L Umbach; Bryan R Cullen
In-depth analysis of Kaposi's sarcoma-associated herpesvirus microRNA expression provides insights into the mammalian microRNA-processing machinery.
Journal of virology 2010;84(2):695-703.
2009: Jennifer L Umbach; Maria A Nagel; Randall J Cohrs; Donald H Gilden; Bryan R Cullen
Analysis of human alphaherpesvirus microRNA expression in latently infected human trigeminal ganglia.
Journal of virology 2009;83(20):10677-83.
2009: Jennifer L Umbach; Bryan R Cullen
The role of RNAi and microRNAs in animal virus replication and antiviral immunity.
Genes & development 2009;23(10):1151-64.
2008: Hal P Bogerd; Rebecca L Tallmadge; J Lindsay Oaks; Susan Carpenter; Bryan R Cullen
Equine infectious anemia virus resists the antiretroviral activity of equine APOBEC3 proteins through a packaging-independent mechanism.
Journal of virology 2008;82(23):11889-901.
2008: Barry D Gooch; Bryan R Cullen
Functional domain organization of human APOBEC3G.
Virology 2008;379(1):118-24.
2008: Jennifer Lin Umbach; Martha F Kramer; Igor Jurak; Heather W Karnowski; Donald M Coen; Bryan R Cullen
MicroRNAs expressed by herpes simplex virus 1 during latent infection regulate viral mRNAs.
Nature 2008;454(7205):780-3.
2008: Eva Gottwein; Bryan R Cullen
Viral and cellular microRNAs as determinants of viral pathogenesis and immunity.
Cell host & microbe 2008;3(6):375-87.
2008: Hal P Bogerd; Bryan R Cullen
Single-stranded RNA facilitates nucleocapsid: APOBEC3G complex formation.
RNA (New York, N.Y.) 2008;14(6):1228-36.
2007: Eva Gottwein; Neelanjan Mukherjee; Christoph Sachse; Corina Frenzel; William H Majoros; Jen-Tsan Chi; Ravi Braich; Muthiah Manoharan; juergen soutschek; Uwe Ohler; Bryan R Cullen
A viral microRNA functions as an orthologue of cellular miR-155.
Nature 2007;450(7172):1096-9.
2007: Heather L Wiegand; Bryan R Cullen
Inhibition of alpharetrovirus replication by a range of human APOBEC3 proteins.
Journal of virology 2007;81(24):13694-9.
2007: Jennifer Lin; Bryan R Cullen
Analysis of the interaction of primate retroviruses with the human RNA interference machinery.
Journal of virology 2007;81(22):12218-26.
2007: Hal P Bogerd; Heather L Wiegand; Brian P Doehle; Bryan R Cullen
The intrinsic antiretroviral factor APOBEC3B contains two enzymatically active cytidine deaminase domains.
Virology 2007;364(2):486-93.
2007: Bryan R Cullen
Immunology. Outwitted by viral RNAs.
Science (New York, N.Y.) 2007;317(5836):329-30.
2007: Alexandra Schäfer; Xuezhong Cai; John P Bilello; Ronald C Desrosiers; Bryan R Cullen
Cloning and analysis of microRNAs encoded by the primate gamma-herpesvirus rhesus monkey rhadinovirus.
Virology 2007;364(1):21-7.
2007: Xuezhong Cai; Bryan R Cullen
The imprinted H19 noncoding RNA is a primary microRNA precursor.
RNA (New York, N.Y.) 2007;13(3):313-6.
2007: Eva Gottwein; Bryan R Cullen
Protocols for expression and functional analysis of viral microRNAs.
Methods in enzymology 2007;427():229-43.
2006: Brian P Doehle; Hal P Bogerd; Heather L Wiegand; Nolwenn Jouvenet; Paul D Bieniasz; Eric Hunter; Bryan R Cullen
The betaretrovirus Mason-Pfizer monkey virus selectively excludes simian APOBEC3G from virion particles.
Journal of virology 2006;80(24):12102-8.
2006: Xuezhong Cai; Gu Li; Laimonis A Laimins; Bryan R Cullen
Human papillomavirus genotype 31 does not express detectable microRNA levels during latent or productive virus replication.
Journal of virology 2006;80(21):10890-3.
2006: Bryan R Cullen
Enhancing and confirming the specificity of RNAi experiments.
Nature methods 2006;3(9):677-81.
2006: Hal P Bogerd; Heather L Wiegand; Amy E Hulme; José L Garcia-Perez; K Sue O'Shea; John V Moran; Bryan R Cullen
Cellular inhibitors of long interspersed element 1 and Alu retrotransposition.
Proceedings of the National Academy of Sciences of the United States of America 2006;103(23):8780-5.
2006: Bryan R Cullen
Viruses and microRNAs.
Nature genetics 2006;38 Suppl():S25-30.
2006: Bryan R Cullen
Is RNA interference involved in intrinsic antiviral immunity in mammals?
Nature immunology 2006;7(6):563-7.
2006: Eva Gottwein; Xuezhong Cai; Bryan R Cullen
A novel assay for viral microRNA function identifies a single nucleotide polymorphism that affects Drosha processing.
Journal of virology 2006;80(11):5321-6.
2006: Xuezhong Cai; Alexandra Schäfer; Shihua Lu; John P Bilello; Ronald C Desrosiers; Rachel Edwards; Nancy Raab-Traub; Bryan R Cullen
Epstein-Barr virus microRNAs are evolutionarily conserved and differentially expressed.
PLoS pathogens 2006;2(3):e23.
2006: Xuezhong Cai; Bryan R Cullen
Transcriptional origin of Kaposi's sarcoma-associated herpesvirus microRNAs.
Journal of virology 2006;80(5):2234-42.
2006: Bryan R Cullen
Induction of stable RNA interference in mammalian cells.
Gene therapy 2006;13(6):503-8.
2006: Bryan R Cullen
Role and mechanism of action of the APOBEC3 family of antiretroviral resistance factors.
Journal of virology 2006;80(3):1067-76.
2006: Eva Gottwein; Xuezhong Cai; Bryan R Cullen
Expression and function of microRNAs encoded by Kaposi's sarcoma-associated herpesvirus.
Cold Spring Harbor symposia on quantitative biology 2006;71():357-64.
2006: Hal P Bogerd; Heather L Wiegand; Brian P Doehle; Kira K Lueders; Bryan R Cullen
APOBEC3A and APOBEC3B are potent inhibitors of LTR-retrotransposon function in human cells.
Nucleic acids research 2006;34(1):89-95.
2005: Brian P Doehle; Alexandra Schäfer; Bryan R Cullen
Human APOBEC3B is a potent inhibitor of HIV-1 infectivity and is resistant to HIV-1 Vif.
Virology 2005;339(2):281-8.
2005: Yan Zeng; Bryan R Cullen
Efficient processing of primary microRNA hairpins by Drosha requires flanking nonstructured RNA sequences.
The Journal of biological chemistry 2005;280(30):27595-603.
2005: Joseph Heitman; Bryan R Cullen
Cyclophilin B escorts the hepatitis C virus RNA polymerase: a viral achilles heel?
Molecular cell 2005;19(2):145-6.
2005: Brian P Doehle; Alexandra Schäfer; Heather L Wiegand; Hal P Bogerd; Bryan R Cullen
Differential sensitivity of murine leukemia virus to APOBEC3-mediated inhibition is governed by virion exclusion.
Journal of virology 2005;79(13):8201-7.
2005: Xuezhong Cai; Shihua Lu; Zhihong Zhang; Carlos M Gonzalez; Blossom Damania; Bryan R Cullen
Kaposi's sarcoma-associated herpesvirus expresses an array of viral microRNAs in latently infected cells.
Proceedings of the National Academy of Sciences of the United States of America 2005;102(15):5570-5.
2005: Rui Yi; Brian P Doehle; Yi Qin; Ian G Macara; Bryan R Cullen
Overexpression of exportin 5 enhances RNA interference mediated by short hairpin RNAs and microRNAs.
RNA (New York, N.Y.) 2005;11(2):220-6.
2005: Yan Zeng; Rui Yi; Bryan R Cullen
Recognition and cleavage of primary microRNA precursors by the nuclear processing enzyme Drosha.
The EMBO journal 2005;24(1):138-48.
2005: Bryan R Cullen
Does RNA interference have a future as a treatment for HIV-1 induced disease?
AIDS reviews 2005;7(1):22-5.
2005: Yan Zeng; Xuezhong Cai; Bryan R Cullen
Use of RNA polymerase II to transcribe artificial microRNAs.
Methods in enzymology 2005;392():371-80.
2004: Bryan R Cullen
Transcription and processing of human microRNA precursors.
Molecular cell 2004;16(6):861-5.
2004: Shihua Lu; Bryan R Cullen
Adenovirus VA1 noncoding RNA can inhibit small interfering RNA and MicroRNA biogenesis.
Journal of virology 2004;78(23):12868-76.
2004: Xuezhong Cai; Curt H Hagedorn; Bryan R Cullen
Human microRNAs are processed from capped, polyadenylated transcripts that can also function as mRNAs.
RNA (New York, N.Y.) 2004;10(12):1957-66.
2004: Alexandra Schäfer; Hal P Bogerd; Bryan R Cullen
Specific packaging of APOBEC3G into HIV-1 virions is mediated by the nucleocapsid domain of the gag polyprotein precursor.
Virology 2004;328(2):163-8.
2004: Heather L Wiegand; Brian P Doehle; Hal P Bogerd; Bryan R Cullen
A second human antiretroviral factor, APOBEC3F, is suppressed by the HIV-1 and HIV-2 Vif proteins.
The EMBO journal 2004;23(12):2451-8.
2004: Bryan R Cullen
Derivation and function of small interfering RNAs and microRNAs.
Virus research 2004;102(1):3-9.
2004: Shihua Lu; Bryan R Cullen
Nonsense mediated decay induced by tethered human UPF3B is restricted to the cytoplasm.
RNA biology 2004;1(1):42-7.
2004: Hal P Bogerd; Brian P Doehle; Heather L Wiegand; Bryan R Cullen
A single amino acid difference in the host APOBEC3G protein controls the primate species specificity of HIV type 1 virion infectivity factor.
Proceedings of the National Academy of Sciences of the United States of America 2004;101(11):3770-4.
2004: Yan Zeng; Bryan R Cullen
Structural requirements for pre-microRNA binding and nuclear export by Exportin 5.
Nucleic acids research 2004;32(16):4776-85.
2004: Bryan R Cullen
Assaying nuclear messenger RNA export in human cells.
Methods in molecular biology (Clifton, N.J.) 2004;257():85-92.
2003: Rui Yi; Yi Qin; Ian G Macara; Bryan R Cullen
Exportin-5 mediates the nuclear export of pre-microRNAs and short hairpin RNAs.
Genes & development 2003;17(24):3011-6.
2003: M T Michael Lee; Glen A Coburn; Myra O McClure; Bryan R Cullen
Inhibition of human immunodeficiency virus type 1 replication in primary macrophages by using Tat- or CCR5-specific small interfering RNAs expressed from a lentivirus vector.
Journal of virology 2003;77(22):11964-72.
2003: Bryan R Cullen
HIV-1 Vif: counteracting innate antiretroviral defenses.
Molecular therapy : the journal of the American Society of Gene Therapy 2003;8(4):525-7.
2003: Heather L Wiegand; Shihua Lu; Bryan R Cullen
Exon junction complexes mediate the enhancing effect of splicing on mRNA expression.
Proceedings of the National Academy of Sciences of the United States of America 2003;100(20):11327-32.
2003: Yan Zeng; Rui Yi; Bryan R Cullen
MicroRNAs and small interfering RNAs can inhibit mRNA expression by similar mechanisms.
Proceedings of the National Academy of Sciences of the United States of America 2003;100(17):9779-84.
2003: Bryan R Cullen
Nuclear mRNA export: insights from virology.
Trends in biochemical sciences 2003;28(8):419-24.
2003: Shihua Lu; Bryan R Cullen
Analysis of the stimulatory effect of splicing on mRNA production and utilization in mammalian cells.
RNA (New York, N.Y.) 2003;9(5):618-30.
2003: Glen A Coburn; Bryan R Cullen
siRNAs: a new wave of RNA-based therapeutics.
The Journal of antimicrobial chemotherapy 2003;51(4):753-6.
2003: Bryan R Cullen
Nuclear RNA export.
Journal of cell science 2003;116(Pt 4):587-97.
2003: Yan Zeng; Bryan R Cullen
Sequence requirements for micro RNA processing and function in human cells.
RNA (New York, N.Y.) 2003;9(1):112-23.
2002: Glen A Coburn; Bryan R Cullen
Potent and specific inhibition of human immunodeficiency virus type 1 replication by RNA interference.
Journal of virology 2002;76(18):9225-31.
2002: Yan Zeng; Bryan R Cullen
RNA interference in human cells is restricted to the cytoplasm.
RNA (New York, N.Y.) 2002;8(7):855-60.
2002: Bryan R Cullen
RNA interference: antiviral defense and genetic tool.
Nature immunology 2002;3(7):597-9.
2002: Yan Zeng; Eric J Wagner; Bryan R Cullen
Both natural and designed micro RNAs can inhibit the expression of cognate mRNAs when expressed in human cells.
Molecular cell 2002;9(6):1327-33.
2002: Rui Yi; Hal P Bogerd; Bryan R Cullen
Recruitment of the Crm1 nuclear export factor is sufficient to induce cytoplasmic expression of incompletely spliced human immunodeficiency virus mRNAs.
Journal of virology 2002;76(5):2036-42.
2002: Dona N Ho; Glen A Coburn; Yibin Kang; Bryan R Cullen; Millie M Georgiadis
The crystal structure and mutational analysis of a novel RNA-binding domain found in the human Tap nuclear mRNA export factor.
Proceedings of the National Academy of Sciences of the United States of America 2002;99(4):1888-93.
2002: Rui Yi; Hal P Bogerd; Heather L Wiegand; Bryan R Cullen
Both ran and importins have the ability to function as nuclear mRNA export factors.
RNA (New York, N.Y.) 2002;8(2):180-7.
2002: Bryan R Cullen
Using retroviruses to study the nuclear export of mRNA.
Results and problems in cell differentiation 2002;35():151-68.
2002: Heather L Wiegand; Glen A Coburn; Yan Zeng; Yibin Kang; Hal P Bogerd; Bryan R Cullen
Formation of Tap/NXT1 heterodimers activates Tap-dependent nuclear mRNA export by enhancing recruitment to nuclear pore complexes.
Molecular and cellular biology 2002;22(1):245-56.
2001: Jinzeng Yang; Hal P Bogerd; P J Wang; D C Page; Bryan R Cullen
Two closely related human nuclear export factors utilize entirely distinct export pathways.
Molecular cell 2001;8(2):397-406.
2001: Kenzo Tokunaga; M L Greenberg; Michael A Morse; R Ian Cumming; H Kim Lyerly; Bryan R Cullen
Molecular basis for cell tropism of CXCR4-dependent human immunodeficiency virus type 1 isolates.
Journal of virology 2001;75(15):6776-85.
2001: Bryan R Cullen
Journey to the center of the cell.
Cell 2001;105(6):697-700.
2001: Glen A Coburn; Heather L Wiegand; Yibin Kang; D N Ho; Millie M Georgiadis; Bryan R Cullen
Using viral species specificity to define a critical protein/RNA interaction surface.
Genes & development 2001;15(10):1194-205.
2000: Jinzeng Yang; Hal P Bogerd; S Y Le; Bryan R Cullen
The human endogenous retrovirus K Rev response element coincides with a predicted RNA folding region.
RNA (New York, N.Y.) 2000;6(11):1551-64.
2000: Hal P Bogerd; Heather L Wiegand; Jinzeng Yang; Bryan R Cullen
Mutational definition of functional domains within the Rev homolog encoded by human endogenous retrovirus K.
Journal of virology 2000;74(20):9353-61.
2000: Yibin Kang; Hal P Bogerd; Bryan R Cullen
Analysis of cellular factors that mediate nuclear export of RNAs bearing the Mason-Pfizer monkey virus constitutive transport element.
Journal of virology 2000;74(13):5863-71.
2000: Bryan R Cullen
Nuclear RNA export pathways.
Molecular and cellular biology 2000;20(12):4181-7.
2000: Hal P Bogerd; Heather L Wiegand; Paul D Bieniasz; Bryan R Cullen
Functional differences between human and bovine immunodeficiency virus Tat transcription factors.
Journal of virology 2000;74(10):4666-71.
2000: Bryan R Cullen
Connections between the processing and nuclear export of mRNA: evidence for an export license?
Proceedings of the National Academy of Sciences of the United States of America 2000;97(1):4-6.
2000: Bryan R Cullen
Principles and applications of a Tat-based assay for analyzing specific RNA-protein interactions in mammalian cells.
Methods in enzymology 2000;328():322-9.
2000: Bryan R Cullen
Utility of the secreted placental alkaline phosphatase reporter enzyme.
Methods in enzymology 2000;326():159-64.
1999: Jinzeng Yang; Bryan R Cullen
Structural and functional analysis of the avian leukemia virus constitutive transport element.
RNA (New York, N.Y.) 1999;5(12):1645-55.
1999: Jinzeng Yang; Hal P Bogerd; S Peng; Heather L Wiegand; R Truant; Bryan R Cullen
An ancient family of human endogenous retroviruses encodes a functional homolog of the HIV-1 Rev protein.
Proceedings of the National Academy of Sciences of the United States of America 1999;96(23):13404-8.
1999: R Truant; Yibin Kang; Bryan R Cullen
The human tap nuclear RNA export factor contains a novel transportin-dependent nuclear localization signal that lacks nuclear export signal function.
The Journal of biological chemistry 1999;274(45):32167-71.
1999: Yibin Kang; Hal P Bogerd; Jinzeng Yang; Bryan R Cullen
Analysis of the RNA binding specificity of the human tap protein, a constitutive transport element-specific nuclear RNA export factor.
Virology 1999;262(1):200-9.
1999: Paul D Bieniasz; TA Grdina; Hal P Bogerd; Bryan R Cullen
Recruitment of cyclin T1/P-TEFb to an HIV type 1 long terminal repeat promoter proximal RNA target is both necessary and sufficient for full activation of transcription.
Proceedings of the National Academy of Sciences of the United States of America 1999;96(14):7791-6.
1999: Paul D Bieniasz; TA Grdina; Hal P Bogerd; Bryan R Cullen
Highly divergent lentiviral Tat proteins activate viral gene expression by a common mechanism.
Molecular and cellular biology 1999;19(7):4592-9.
1999: Paul D Bieniasz; TA Grdina; Hal P Bogerd; Bryan R Cullen
Analysis of the effect of natural sequence variation in Tat and in cyclin T on the formation and RNA binding properties of Tat-cyclin T complexes.
Journal of virology 1999;73(7):5777-86.
1999: Yibin Kang; Bryan R Cullen
The human Tap protein is a nuclear mRNA export factor that contains novel RNA-binding and nucleocytoplasmic transport sequences.
Genes & development 1999;13(9):1126-39.
1999: Hal P Bogerd; RE Benson; R Truant; A Herold; M Phingbodhipakkiya; Bryan R Cullen
Definition of a consensus transportin-specific nucleocytoplasmic transport signal.
The Journal of biological chemistry 1999;274(14):9771-7.
1999: R Truant; Bryan R Cullen
The arginine-rich domains present in human immunodeficiency virus type 1 Tat and Rev function as direct importin beta-dependent nuclear localization signals.
Molecular and cellular biology 1999;19(2):1210-7.
1999: Ted M Ross; Paul D Bieniasz; Bryan R Cullen
Role of chemokine receptors in HIV-1 infection and pathogenesis.
Advances in virus research 1999;52():233-67.
1998: R Truant; RA Fridell; E R Benson; A Herold; Bryan R Cullen
Nucleocytoplasmic shuttling by protein nuclear import factors.
European journal of cell biology 1998;77(4):269-75.
1998: Paul D Bieniasz; TA Grdina; Hal P Bogerd; Bryan R Cullen
Recruitment of a protein complex containing Tat and cyclin T1 to TAR governs the species specificity of HIV-1 Tat.
The EMBO journal 1998;17(23):7056-65.
1998: Hal P Bogerd; Asier Echarri; Ted M Ross; Bryan R Cullen
Inhibition of human immunodeficiency virus Rev and human T-cell leukemia virus Rex function, but not Mason-Pfizer monkey virus constitutive transport element activity, by a mutant human nucleoporin targeted to Crm1.
Journal of virology 1998;72(11):8627-35.
1998: A Herold; R Truant; Heather L Wiegand; Bryan R Cullen
Determination of the functional domain organization of the importin alpha nuclear import factor.
The Journal of cell biology 1998;143(2):309-18.
1998: Bryan R Cullen
Retroviruses as model systems for the study of nuclear RNA export pathways.
Virology 1998;249(2):203-10.
1998: Yibin Kang; Bryan R Cullen
Derivation and functional characterization of a consensus DNA binding sequence for the tas transcriptional activator of simian foamy virus type 1.
Journal of virology 1998;72(7):5502-9.
1998: Ted M Ross; Bryan R Cullen
The ability of HIV type 1 to use CCR-3 as a coreceptor is controlled by envelope V1/V2 sequences acting in conjunction with a CCR-5 tropic V3 loop.
Proceedings of the National Academy of Sciences of the United States of America 1998;95(13):7682-6.
1998: Bryan R Cullen
HIV-1 auxiliary proteins: making connections in a dying cell.
Cell 1998;93(5):685-92.
1998: Ted M Ross; Paul D Bieniasz; Bryan R Cullen
Multiple residues contribute to the inability of murine CCR-5 to function as a coreceptor for macrophage-tropic human immunodeficiency virus type 1 isolates.
Journal of virology 1998;72(3):1918-24.
1998: R Truant; RA Fridell; RE Benson; Hal P Bogerd; Bryan R Cullen
Identification and functional characterization of a novel nuclear localization signal present in the yeast Nab2 poly(A)+ RNA binding protein.
Molecular and cellular biology 1998;18(3):1449-58.
1998: WS Blair; Todd B Parsley; Hal P Bogerd; Jonathan S Towner; Bert L Semler; Bryan R Cullen
Utilization of a mammalian cell-based RNA binding assay to characterize the RNA binding properties of picornavirus 3C proteinases.
RNA (New York, N.Y.) 1998;4(2):215-25.
1998: Yibin Kang; WS Blair; Bryan R Cullen
Identification and functional characterization of a high-affinity Bel-1 DNA binding site located in the human foamy virus internal promoter.
Journal of virology 1998;72(1):504-11.
1998: Paul D Bieniasz; Bryan R Cullen
Chemokine receptors and human immunodeficiency virus infection.
Frontiers in bioscience : a journal and virtual library 1998;3():d44-58.
1997: Paul D Bieniasz; RA Fridell; Kelly K Anthony; Bryan R Cullen
Murine CXCR-4 is a functional coreceptor for T-cell-tropic and dual-tropic strains of human immunodeficiency virus type 1.
Journal of virology 1997;71(9):7097-100.
1997: J Hua; Bryan R Cullen
Human immunodeficiency virus types 1 and 2 and simian immunodeficiency virus Nef use distinct but overlapping target sites for downregulation of cell surface CD4.
Journal of virology 1997;71(9):6742-8.
1997: RA Fridell; R Truant; L Thorne; RE Benson; Bryan R Cullen
Nuclear import of hnRNP A1 is mediated by a novel cellular cofactor related to karyopherin-beta.
Journal of cell science 1997;110 ( Pt 11)():1325-31.
1997: Paul D Bieniasz; RA Fridell; I Aramori; Stephen S G Ferguson; Marc G Caron; Bryan R Cullen
HIV-1-induced cell fusion is mediated by multiple regions within both the viral envelope and the CCR-5 co-receptor.
The EMBO journal 1997;16(10):2599-609.
1997: J Hua; WS Blair; R Truant; Bryan R Cullen
Identification of regions in HIV-1 Nef required for efficient downregulation of cell surface CD4.
Virology 1997;231(2):231-8.
1997: WS Blair; Bryan R Cullen
A yeast TATA-binding protein mutant that selectively enhances gene expression from weak RNA polymerase II promoters.
Molecular and cellular biology 1997;17(5):2888-96.
1996: Bryan R Cullen
HIV-1: is Nef a PAK animal?
Current biology : CB 1996;6(12):1557-9.
1996: RA Fridell; R E Benson; J Hua; Hal P Bogerd; Bryan R Cullen
A nuclear role for the Fragile X mental retardation protein.
The EMBO journal 1996;15(19):5408-14.
1996: J Hua; J J Caffrey; Bryan R Cullen
Functional consequences of natural sequence variation in the activation domain of HIV-1 Rev.
Virology 1996;222(2):423-9.
1996: Hal P Bogerd; RA Fridell; R E Benson; J Hua; Bryan R Cullen
Protein sequence requirements for function of the human T-cell leukemia virus type 1 Rex nuclear export signal delineated by a novel in vivo randomization-selection assay.
Molecular and cellular biology 1996;16(8):4207-14.
1996: RA Fridell; Hal P Bogerd; Bryan R Cullen
Nuclear export of late HIV-1 mRNAs occurs via a cellular protein export pathway.
Proceedings of the National Academy of Sciences of the United States of America 1996;93(9):4421-4.
1996: RA Fridell; U Fischer; Reinhard Lührmann; BE Meyer; J L Meinkoth; Michael H Malim; Bryan R Cullen
Amphibian transcription factor IIIA proteins contain a sequence element functionally equivalent to the nuclear export signal of human immunodeficiency virus type 1 Rev.
Proceedings of the National Academy of Sciences of the United States of America 1996;93(7):2936-40.
1996: WS Blair; RA Fridell; Bryan R Cullen
Synergistic enhancement of both initiation and elongation by acidic transcription activation domains.
The EMBO journal 1996;15(7):1658-65.
1995: Hal P Bogerd; RA Fridell; S Madore; Bryan R Cullen
Identification of a novel cellular cofactor for the Rev/Rex class of retroviral regulatory proteins.
Cell 1995;82(3):485-94.
1995: RA Fridell; L S Harding; Hal P Bogerd; Bryan R Cullen
Identification of a novel human zinc finger protein that specifically interacts with the activation domain of lentiviral Tat proteins.
Virology 1995;209(2):347-57.
1995: S J Madore; Bryan R Cullen
Functional similarities between HIV-1 Tat and DNA sequence-specific transcriptional activators.
Virology 1995;206(2):1150-4.
1995: Bryan R Cullen
Regulation of HIV gene expression.
AIDS (London, England) 1995;9 Suppl A():S19-32.
1994: Bryan R Cullen
The role of Nef in the replication cycle of the human and simian immunodeficiency viruses.
Virology 1994;205(1):1-6.
1994: WS Blair; Hal P Bogerd; S J Madore; Bryan R Cullen
Mutational analysis of the transcription activation domain of RelA: identification of a highly synergistic minimal acidic activation module.
Molecular and cellular biology 1994;14(11):7226-34.
1994: S J Madore; L S Tiley; Michael H Malim; Bryan R Cullen
Sequence requirements for Rev multimerization in vivo.
Virology 1994;202(1):186-94.
1994: WS Blair; Hal P Bogerd; Bryan R Cullen
Genetic analysis indicates that the human foamy virus Bel-1 protein contains a transcription activation domain of the acidic class.
Journal of virology 1994;68(6):3803-8.
1994: Bryan R Cullen
RNA-sequence-mediated gene regulation in HIV-1.
Infectious agents and disease 1994;3(2-3):68-76.
1994: A Sanfridson; Bryan R Cullen; Carolyn Doyle
The simian immunodeficiency virus Nef protein promotes degradation of CD4 in human T cells.
The Journal of biological chemistry 1994;269(6):3917-20.
1993: RA Fridell; K M Partin; S Carpenter; Bryan R Cullen
Identification of the activation domain of equine infectious anemia virus rev.
Journal of virology 1993;67(12):7317-23.
1993: E D Garrett; F He; Hal P Bogerd; Bryan R Cullen
Transcriptional trans activators of human and simian foamy viruses contain a small, highly conserved activation domain.
Journal of virology 1993;67(11):6824-7.
1993: Hal P Bogerd; RA Fridell; WS Blair; Bryan R Cullen
Genetic evidence that the Tat proteins of human immunodeficiency virus types 1 and 2 can multimerize in the eukaryotic cell nucleus.
Journal of virology 1993;67(8):5030-4.
1993: S J Madore; Bryan R Cullen
Genetic analysis of the cofactor requirement for human immunodeficiency virus type 1 Tat function.
Journal of virology 1993;67(7):3703-11.
1993: R E Benson; A Sanfridson; Janet Ottinger; Carolyn Doyle; Bryan R Cullen
Downregulation of cell-surface CD4 expression by simian immunodeficiency virus Nef prevents viral super infection.
The Journal of experimental medicine 1993;177(6):1561-6.
1993: Bryan R Cullen
Does HIV-1 Tat induce a change in viral initiation rights?
Cell 1993;73(3):417-20.
1993: F He; J D Sun; E D Garrett; Bryan R Cullen
Functional organization of the Bel-1 trans activator of human foamy virus.
Journal of virology 1993;67(4):1896-904.
1992: Hal P Bogerd; L S Tiley; Bryan R Cullen
Specific binding of the human T-cell leukemia virus type I Rex protein to a short RNA sequence located within the Rex-response element.
Journal of virology 1992;66(12):7572-5.
1992: L S Tiley; S J Madore; Michael H Malim; Bryan R Cullen
The VP16 transcription activation domain is functional when targeted to a promoter-proximal RNA sequence.
Genes & development 1992;6(11):2077-87.
1992: Michael H Malim; W W Freimuth; J Liu; T J Boyle; H K Lyerly; Bryan R Cullen; Gary Nabel
Stable expression of transdominant Rev protein in human T cells inhibits human immunodeficiency virus replication.
The Journal of experimental medicine 1992;176(4):1197-201.
1992: Bryan R Cullen
Mechanism of action of regulatory proteins encoded by complex retroviruses.
Microbiological reviews 1992;56(3):375-94.
1992: H Chen; T J Boyle; Michael H Malim; Bryan R Cullen; H Kim Lyerly
Derivation of a biologically contained replication system for human immunodeficiency virus type 1.
Proceedings of the National Academy of Sciences of the United States of America 1992;89(16):7678-82.
1992: S S Hwang; T J Boyle; H Kim Lyerly; Bryan R Cullen
Identification of envelope V3 loop as the major determinant of CD4 neutralization sensitivity of HIV-1.
Science (New York, N.Y.) 1992;257(5069):535-7.
1992: E D Garrett; Bryan R Cullen
Comparative analysis of Rev function in human immunodeficiency virus types 1 and 2.
Journal of virology 1992;66(7):4288-94.
1992: A Keller; E D Garrett; Bryan R Cullen
The Bel-1 protein of human foamy virus activates human immunodeficiency virus type 1 gene expression via a novel DNA target site.
Journal of virology 1992;66(6):3946-9.
1992: L S Tiley; Bryan R Cullen
Structural and functional analysis of the visna virus Rev-response element.
Journal of virology 1992;66(6):3609-15.
1992: Bryan R Cullen; E D Garrett
A comparison of regulatory features in primate lentiviruses.
AIDS research and human retroviruses 1992;8(3):387-93.
1992: L S Tiley; Michael H Malim; H K Tewary; Peter G Stockley; Bryan R Cullen
Identification of a high-affinity RNA-binding site for the human immunodeficiency virus type 1 Rev protein.
Proceedings of the National Academy of Sciences of the United States of America 1992;89(2):758-62.
1991: Mariano A Garcia-Blanco; Bryan R Cullen
Molecular basis of latency in pathogenic human viruses.
Science (New York, N.Y.) 1991;254(5033):815-20.
1991: Bryan R Cullen; Michael H Malim
The HIV-1 Rev protein: prototype of a novel class of eukaryotic post-transcriptional regulators.
Trends in biochemical sciences 1991;16(9):346-50.
1991: Michael H Malim; D F McCarn; L S Tiley; Bryan R Cullen
Mutational definition of the human immunodeficiency virus type 1 Rev activation domain.
Journal of virology 1991;65(8):4248-54.
1991: S S Hwang; T J Boyle; H Kim Lyerly; Bryan R Cullen
Identification of the envelope V3 loop as the primary determinant of cell tropism in HIV-1.
Science (New York, N.Y.) 1991;253(5015):71-4.
1991: P H Brown; L S Tiley; Bryan R Cullen
Effect of RNA secondary structure on polyadenylation site selection.
Genes & development 1991;5(7):1277-84.
1991: Bryan R Cullen
Regulation of HIV-1 gene expression.
FASEB journal : official publication of the Federation of American Societies for Experimental Biology 1991;5(10):2361-8.
1991: L S Tiley; Michael H Malim; Bryan R Cullen
Conserved functional organization of the human immunodeficiency virus type 1 and visna virus Rev proteins.
Journal of virology 1991;65(7):3877-81.
1991: P H Brown; L S Tiley; Bryan R Cullen
Efficient polyadenylation within the human immunodeficiency virus type 1 long terminal repeat requires flanking U3-specific sequences.
Journal of virology 1991;65(6):3340-3.
1991: A Keller; K M Partin; Martin Löchelt; H Bannert; Rolf M Flügel; Bryan R Cullen
Characterization of the transcriptional trans activator of human foamy retrovirus.
Journal of virology 1991;65(5):2589-94.
1991: Michael H Malim; Bryan R Cullen
HIV-1 structural gene expression requires the binding of multiple Rev monomers to the viral RRE: implications for HIV-1 latency.
Cell 1991;65(2):241-8.
1991: Bryan R Cullen
Human immunodeficiency virus as a prototypic complex retrovirus.
Journal of virology 1991;65(3):1053-6.
1991: E D Garrett; L S Tiley; Bryan R Cullen
Rev activates expression of the human immunodeficiency virus type 1 vif and vpr gene products.
Journal of virology 1991;65(3):1653-7.
1991: Bryan R Cullen
Regulation of gene expression in the human immunodeficiency virus type 1.
Advances in virus research 1991;40():1-17.
1991: Bryan R Cullen
Regulation of human immunodeficiency virus replication.
Annual review of microbiology 1991;45():219-50.
1990: Bryan R Cullen
The HIV-1 Tat protein: an RNA sequence-specific processivity factor?
Cell 1990;63(4):655-7.
1990: L S Tiley; P H Brown; Bryan R Cullen
Does the human immunodeficiency virus Tat trans-activator contain a discrete activation domain?
Virology 1990;178(2):560-7.
1990: L S Tiley; P H Brown; S Y Le; jacob valentine maizel; Janice E Clements; Bryan R Cullen
Visna virus encodes a post-transcriptional regulator of viral structural gene expression.
Proceedings of the National Academy of Sciences of the United States of America 1990;87(19):7497-501.
1990: Bryan R Cullen; Warner Greene
Functions of the auxiliary gene products of the human immunodeficiency virus type 1.
Virology 1990;178(1):1-5.
1990: Yasmath Ahmed; S M Hanly; Michael H Malim; Bryan R Cullen; Warner Greene
Structure-function analyses of the HTLV-I Rex and HIV-1 Rev RNA response elements: insights into the mechanism of Rex and Rev action.
Genes & development 1990;4(6):1014-22.
1990: Michael H Malim; L S Tiley; D F McCarn; J R Rusche; Joachim Hauber; Bryan R Cullen
HIV-1 structural gene expression requires binding of the Rev trans-activator to its RNA target sequence.
Cell 1990;60(4):675-83.
1989: S R Hammes; E P Dixon; Michael H Malim; Bryan R Cullen; Warner Greene
Nef protein of human immunodeficiency virus type 1: evidence against its role as a transcriptional inhibitor.
Proceedings of the National Academy of Sciences of the United States of America 1989;86(23):9549-53.
1989: R Fenrick; Michael H Malim; Joachim Hauber; S Y Le; J Maizel; Bryan R Cullen
Functional analysis of the Tat trans activator of human immunodeficiency virus type 2.
Journal of virology 1989;63(12):5006-12.
1989: Michael H Malim; S Böhnlein; R Fenrick; S Y Le; jacob valentine maizel; Bryan R Cullen
Functional comparison of the Rev trans-activators encoded by different primate immunodeficiency virus species.
Proceedings of the National Academy of Sciences of the United States of America 1989;86(21):8222-6.
1989: S M Hanly; Laurence Rimsky; Michael H Malim; J H Kim; Joachim Hauber; M Duc Dodon; S Y Le; jacob valentine maizel; Bryan R Cullen; Warner Greene
Comparative analysis of the HTLV-I Rex and HIV-1 Rev trans-regulatory proteins and their RNA response elements.
Genes & development 1989;3(10):1534-44.
1989: Bryan R Cullen; Warner Greene
Regulatory pathways governing HIV-1 replication.
Cell 1989;58(3):423-6.
1989: Michael H Malim; R Fenrick; Dean W Ballard; Joachim Hauber; E Böhnlein; Bryan R Cullen
Functional characterization of a complex protein-DNA-binding domain located within the human immunodeficiency virus type 1 long terminal repeat leader region.
Journal of virology 1989;63(8):3213-9.
1989: Michael H Malim; S Böhnlein; Joachim Hauber; Bryan R Cullen
Functional dissection of the HIV-1 Rev trans-activator--derivation of a trans-dominant repressor of Rev function.
Cell 1989;58(1):205-14.
1989: Michael H Malim; Joachim Hauber; S Y Le; jacob valentine maizel; Bryan R Cullen
The HIV-1 rev trans-activator acts through a structured target sequence to activate nuclear export of unspliced viral mRNA.
Nature 1989;338(6212):254-7.
1989: Joachim Hauber; Michael H Malim; Bryan R Cullen
Mutational analysis of the conserved basic domain of human immunodeficiency virus tat protein.
Journal of virology 1989;63(3):1181-7.
1989: S Böhnlein; Joachim Hauber; Bryan R Cullen
Identification of a U5-specific sequence required for efficient polyadenylation within the human immunodeficiency virus long terminal repeat.
Journal of virology 1989;63(1):421-4.
1988: Joachim Hauber; M Bouvier; Michael H Malim; Bryan R Cullen
Phosphorylation of the rev gene product of human immunodeficiency virus type 1.
Journal of virology 1988;62(12):4801-4.
1988: Laurence Rimsky; Joachim Hauber; M Dukovich; Michael H Malim; A Langlois; Bryan R Cullen; Warner Greene
Functional replacement of the HIV-1 rev protein by the HTLV-1 rex protein.
Nature 1988;335(6192):738-40.
1988: Michael H Malim; Joachim Hauber; R Fenrick; Bryan R Cullen
Immunodeficiency virus rev trans-activator modulates the expression of the viral regulatory genes.
Nature 1988;335(6186):181-3.