Emad Alnemri

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Balakrishnan Meenakshi P; Cilenti Lucia; Mashak Zineb; Popat Paiyal; Alnemri Emad S; Zervos Antonis S
THAP5 is a human cardiac-specific inhibitor of cell cycle that is cleaved by the proapoptotic Omi/HtrA2 protease during cell death.
Bauernfeind Franz G; Horvath Gabor; Stutz Andrea; Alnemri Emad S; MacDonald Kelly; Speert David; Fernandes-Alnemri Teresa; Wu Jianghong; Monks Brian G; Fitzgerald Katherine A; Hornung Veit; Latz Eicke
Cutting edge: NF-kappaB activating pattern recognition and cytokine receptors license NLRP3 inflammasome activation by regulating NLRP3 expression.
Fernandes-Alnemri Teresa; Yu Je-Wook; Datta Pinaki; Wu Jianghong; Alnemri Emad S
AIM2 activates the inflammasome and cell death in response to cytoplasmic DNA.

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2009: Balakrishnan Meenakshi P; Cilenti Lucia; Mashak Zineb; Popat Paiyal; Alnemri Emad S; Zervos Antonis S
THAP5 is a human cardiac-specific inhibitor of cell cycle that is cleaved by the proapoptotic Omi/HtrA2 protease during cell death.
American journal of physiology. Heart and circulatory physiology 2009;297(2):H643-53.
2009: Bauernfeind Franz G; Horvath Gabor; Stutz Andrea; Alnemri Emad S; MacDonald Kelly; Speert David; Fernandes-Alnemri Teresa; Wu Jianghong; Monks Brian G; Fitzgerald Katherine A; Hornung Veit; Latz Eicke
Cutting edge: NF-kappaB activating pattern recognition and cytokine receptors license NLRP3 inflammasome activation by regulating NLRP3 expression.
Journal of immunology (Baltimore, Md. : 1950) 2009;183(2):787-91.
2009: Fernandes-Alnemri Teresa; Yu Je-Wook; Datta Pinaki; Wu Jianghong; Alnemri Emad S
AIM2 activates the inflammasome and cell death in response to cytoplasmic DNA.
Nature 2009;458(7237):509-13.
2008: Dogan Taner; Harms Gregory S; Hekman Mirko; Karreman Christiaan; Oberoi Tripat Kaur; Alnemri Emad S; Rapp Ulf R; Rajalingam Krishnaraj
X-linked and cellular IAPs modulate the stability of C-RAF kinase and cell motility.
Nature cell biology 2008;10(12):1447-55.
2008: Khan F S; Fujioka M; Datta P; Fernandes-Alnemri T; Jaynes J B; Alnemri E S
The interaction of DIAP1 with dOmi/HtrA2 regulates cell death in Drosophila.
Cell death and differentiation 2008;15(6):1073-83.
2008: Ting Jenny P-Y; Lovering Ruth C; Alnemri Emad S; Bertin John; Boss Jeremy M; Davis Beckley K; Flavell Richard A; Girardin Stephen E; Godzik Adam; Harton Jonathan A; Hoffman Hal M; Hugot Jean-Pierre; Inohara Naohiro; Mackenzie Alex; Maltais Lois J; Nunez Gabriel; Ogura Yasunori; Otten Luc A; Philpott Dana; Reed John C; Reith Walter; Schreiber Stefan; Steimle Viktor; Ward Peter A
The NLR gene family: a standard nomenclature.
Immunity 2008;28(3):285-7.
2008: Jéru I; Duquesnoy P; Fernandes-Alnemri T; Cochet E; Yu J W; Lackmy-Port-Lis M; Grimprel E; Landman-Parker J; Hentgen V; Marlin S; McElreavey K; Sarkisian T; Grateau G; Alnemri E S; Amselem S
Mutations in NALP12 cause hereditary periodic fever syndromes.
Proceedings of the National Academy of Sciences of the United States of America 2008;105(5):1614-9.
2008: Fernandes-Alnemri Teresa; Alnemri Emad S
Assembly, purification, and assay of the activity of the ASC pyroptosome.
Methods in enzymology 2008;442():251-70.
2007: Alnemri Emad S
HtrA2 and Parkinson's disease: think PINK?
Nature cell biology 2007;9(11):1227-9.
2007: Yu Je-Wook; Fernandes-Alnemri Teresa; Datta Pinaki; Wu Jianghong; Juliana Christine; Solorzano Leobaldo; McCormick Margaret; Zhang ZhiJia; Alnemri Emad S
Pyrin activates the ASC pyroptosome in response to engagement by autoinflammatory PSTPIP1 mutants.
Molecular cell 2007;28(2):214-27.
2007: Fernandes-Alnemri T; Wu J; Yu J-W; Datta P; Miller B; Jankowski W; Rosenberg S; Zhang J; Alnemri E S
The pyroptosome: a supramolecular assembly of ASC dimers mediating inflammatory cell death via caspase-1 activation.
Cell death and differentiation 2007;14(9):1590-604.
2006: Yu J-W; Wu J; Zhang Z; Datta P; Ibrahimi I; Taniguchi S; Sagara J; Fernandes-Alnemri T; Alnemri E S
Cryopyrin and pyrin activate caspase-1, but not NF-kappaB, via ASC oligomerization.
Cell death and differentiation 2006;13(2):236-49.
2005: Cilenti Lucia; Kyriazis George A; Soundarapandian Mangala M; Stratico Valerie; Yerkes Adam; Park Kwon Moo; Sheridan Alice M; Alnemri Emad S; Bonventre Joseph V; Zervos Antonis S
Omi/HtrA2 protease mediates cisplatin-induced cell death in renal cells.
American journal of physiology. Renal physiology 2005;288(2):F371-9.
2005: Liu Hui-Rong; Gao Erhe; Hu Aihua; Tao Ling; Qu Yan; Most Patrick; Koch Walter J; Christopher Theodore A; Lopez Bernard L; Alnemri Emad S; Zervos Antonis S; Ma Xin L
Role of Omi/HtrA2 in apoptotic cell death after myocardial ischemia and reperfusion.
Circulation 2005;111(1):90-6.
2004: Cilenti Lucia; Soundarapandian Mangala M; Kyriazis George A; Stratico Valerie; Singh Supriya; Gupta Sanjeev; Bonventre Joseph V; Alnemri Emad S; Zervos Antonis S
Regulation of HAX-1 anti-apoptotic protein by Omi/HtrA2 protease during cell death.
The Journal of biological chemistry 2004;279(48):50295-301.
2004: Gupta Sanjeev; Singh Rajesh; Datta Pinaki; Zhang Zhijia; Orr Christopher; Lu Zhixian; Dubois Garrett; Zervos Antonis S; Meisler Miriam H; Srinivasula Srinivasa M; Fernandes-Alnemri Teresa; Alnemri Emad S
The C-terminal tail of presenilin regulates Omi/HtrA2 protease activity.
The Journal of biological chemistry 2004;279(44):45844-54.
2004: Guo Yin; Cheong NaEun; Zhang ZhiJia; De Rose Robert; Deng Yun; Farber Steven A; Fernandes-Alnemri Teresa; Alnemri Emad S
Tim50, a component of the mitochondrial translocator, regulates mitochondrial integrity and cell death.
The Journal of biological chemistry 2004;279(23):24813-25.
2004: Saleh Maya; Vaillancourt John P; Graham Rona K; Huyck Matthew; Srinivasula Srinivasa M; Alnemri Emad S; Steinberg Martin H; Nolan Vikki; Baldwin Clinton T; Hotchkiss Richard S; Buchman Timothy G; Zehnbauer Barbara A; Hayden Michael R; Farrer Lindsay A; Roy Sophie; Nicholson Donald W
Differential modulation of endotoxin responsiveness by human caspase-12 polymorphisms.
Nature 2004;429(6987):75-9.
2003: Jones Julie M; Datta Pinaki; Srinivasula Srinivasa M; Ji Weizhen; Gupta Sanjeev; Zhang ZhiJia; Davies Erika; Hajnóczky György; Saunders Thomas L; Van Keuren Margaret L; Fernandes-Alnemri Teresa; Meisler Miriam H; Alnemri Emad S
Loss of Omi mitochondrial protease activity causes the neuromuscular disorder of mnd2 mutant mice.
Nature 2003;425(6959):721-7.
2003: Hegde Ramesh; Srinivasula Srinivasa M; Datta Pinaki; Madesh Muniswamy; Wassell Richard; Zhang ZhiJia; Cheong NaEun; Nejmeh Julie; Fernandes-Alnemri Teresa; Hoshino Shin-ichi; Alnemri Emad S
The polypeptide chain-releasing factor GSPT1/eRF3 is proteolytically processed into an IAP-binding protein.
The Journal of biological chemistry 2003;278(40):38699-706.
2003: Zeuner A; Eramo A; Testa U; Felli N; Pelosi E; Mariani G; Srinivasula S M; Alnemri E S; Condorelli G; Peschle C; De Maria R
Control of erythroid cell production via caspase-mediated cleavage of transcription factor SCL/Tal-1.
Cell death and differentiation 2003;10(8):905-13.
2003: Srinivasula Srinivasa M; Gupta Sanjeev; Datta Pinaki; Zhang ZhiJia; Hegde Ramesh; Cheong NaEun; Fernandes-Alnemri Teresa; Alnemri Emad S
Inhibitor of apoptosis proteins are substrates for the mitochondrial serine protease Omi/HtrA2.
The Journal of biological chemistry 2003;278(34):31469-72.
2003: Chang David W; Ditsworth Dara; Liu Hongtu; Srinivasula Srinivasa M; Alnemri Emad S; Yang Xiaolu
Oligomerization is a general mechanism for the activation of apoptosis initiator and inflammatory procaspases.
The Journal of biological chemistry 2003;278(19):16466-9.
2003: Kandasamy Karthikeyan; Srinivasula Srinivasa M; Alnemri Emad S; Thompson Craig B; Korsmeyer Stanley J; Bryant Joseph L; Srivastava Rakesh K
Involvement of proapoptotic molecules Bax and Bak in tumor necrosis factor-related apoptosis-inducing ligand (TRAIL)-induced mitochondrial disruption and apoptosis: differential regulation of cytochrome c and Smac/DIABLO release.
Cancer research 2003;63(7):1712-21.
2003: Jia Li; Patwari Yasmeen; Kelsey Stephen M; Srinivasula Srinivasa M; Agrawal Samir G; Alnemri Emad S; Newland Adrian C
Role of Smac in human leukaemic cell apoptosis and proliferation.
Oncogene 2003;22(11):1589-99.
2003: Cilenti Lucia; Lee Younghee; Hess Sibylle; Srinivasula Srinivasa; Park Kwon Moo; Junqueira Daniela; Davis Hedvika; Bonventre Joseph V; Alnemri Emad S; Zervos Antonis S
Characterization of a novel and specific inhibitor for the pro-apoptotic protease Omi/HtrA2.
The Journal of biological chemistry 2003;278(13):11489-94.
2003: Shiozaki Eric N; Chai Jijie; Rigotti Daniel J; Riedl Stefan J; Li Pingwei; Srinivasula Srinivasa M; Alnemri Emad S; Fairman Robert; Shi Yigong
Mechanism of XIAP-mediated inhibition of caspase-9.
Molecular cell 2003;11(2):519-27.
2002: Pistritto G; Jost M; Srinivasula S M; Baffa R; Poyet J-L; Kari C; Lazebnik Y; Rodeck U; Alnemri E S
Expression and transcriptional regulation of caspase-14 in simple and complex epithelia.
Cell death and differentiation 2002;9(9):995-1006.
2002: Li Wenyu; Srinivasula Srinivasa M; Chai Jijie; Li Pingwei; Wu Jia-Wei; Zhang ZhiJia; Alnemri Emad S; Shi Yigong
Structural insights into the pro-apoptotic function of mitochondrial serine protease HtrA2/Omi.
Nature structural biology 2002;9(6):436-41.
2002: Srinivasula Srinivasa M; Poyet Jean-Luc; Razmara Marjaneh; Datta Pinaki; Zhang ZhiJia; Alnemri Emad S
The PYRIN-CARD protein ASC is an activating adaptor for caspase-1.
The Journal of biological chemistry 2002;277(24):21119-22.
2002: Zhan Y; Hegde R; Srinivasula S M; Fernandes-Alnemri T; Alnemri E S
Death effector domain-containing proteins DEDD and FLAME-3 form nuclear complexes with the TFIIIC102 subunit of human transcription factor IIIC.
Cell death and differentiation 2002;9(4):439-47.
2002: Guo Yin; Srinivasula Srinivasa M; Druilhe Anne; Fernandes-Alnemri Teresa; Alnemri Emad S
Caspase-2 induces apoptosis by releasing proapoptotic proteins from mitochondria.
The Journal of biological chemistry 2002;277(16):13430-7.
2002: Razmara Marjaneh; Srinivasula Srinivasa M; Wang Lin; Poyet Jean-Luc; Geddes Brad J; DiStefano Peter S; Bertin John; Alnemri Emad S
CARD-8 protein, a new CARD family member that regulates caspase-1 activation and apoptosis.
The Journal of biological chemistry 2002;277(16):13952-8.
2002: Madesh Muniswamy; Antonsson Bruno; Srinivasula Srinivasa M; Alnemri Emad S; Hajnóczky György
Rapid kinetics of tBid-induced cytochrome c and Smac/DIABLO release and mitochondrial depolarization.
The Journal of biological chemistry 2002;277(7):5651-9.
2002: Srinivasula Srinivasa M; Datta Pinaki; Kobayashi Masatomo; Wu Jia Wei; Fujioka Miki; Hegde Ramesh; Zhang ZhiJia; Mukattash Rula; Fernandes-Alnemri Teresa; Shi Yigong; Jaynes James B; Alnemri Emad S
sickle, a novel Drosophila death gene in the reaper/hid/grim region, encodes an IAP-inhibitory protein.
Current biology : CB 2002;12(2):125-30.
2002: Hegde Ramesh; Srinivasula Srinivasa M; Zhang ZhiJia; Wassell Richard; Mukattash Rula; Cilenti Lucia; DuBois Garrett; Lazebnik Yuri; Zervos Antonis S; Fernandes-Alnemri Teresa; Alnemri Emad S
Identification of Omi/HtrA2 as a mitochondrial apoptotic serine protease that disrupts inhibitor of apoptosis protein-caspase interaction.
The Journal of biological chemistry 2002;277(1):432-8.
2001: Chai J; Wu Q; Shiozaki E; Srinivasula S M; Alnemri E S; Shi Y
Crystal structure of a procaspase-7 zymogen: mechanisms of activation and substrate binding.
Cell 2001;107(3):399-407.
2001: Jia L; Patwari Y; Srinivasula S M; Newland A C; Fernandes-Alnemri T; Alnemri E S; Kelsey S M
Bax translocation is crucial for the sensitivity of leukaemic cells to etoposide-induced apoptosis.
Oncogene 2001;20(35):4817-26.
2001: Poyet J L; Srinivasula S M; Tnani M; Razmara M; Fernandes-Alnemri T; Alnemri E S
Identification of Ipaf, a human caspase-1-activating protein related to Apaf-1.
The Journal of biological chemistry 2001;276(30):28309-13.
2001: Druilhe A; Srinivasula S M; Razmara M; Ahmad M; Alnemri E S
Regulation of IL-1beta generation by Pseudo-ICE and ICEBERG, two dominant negative caspase recruitment domain proteins.
Cell death and differentiation 2001;8(6):649-57.
2001: Wang L; Guo Y; Huang W J; Ke X; Poyet J L; Manji G A; Merriam S; Glucksmann M A; DiStefano P S; Alnemri E S; Bertin J
Card10 is a novel caspase recruitment domain/membrane-associated guanylate kinase family member that interacts with BCL10 and activates NF-kappa B.
The Journal of biological chemistry 2001;276(24):21405-9.
2001: Condorelli F; Salomoni P; Cotteret S; Cesi V; Srinivasula S M; Alnemri E S; Calabretta B
Caspase cleavage enhances the apoptosis-inducing effects of BAD.
Molecular and cellular biology 2001;21(9):3025-36.
2001: Bertin J; Wang L; Guo Y; Jacobson M D; Poyet J L; Srinivasula S M; Merriam S; DiStefano P S; Alnemri E S
CARD11 and CARD14 are novel caspase recruitment domain (CARD)/membrane-associated guanylate kinase (MAGUK) family members that interact with BCL10 and activate NF-kappa B.
The Journal of biological chemistry 2001;276(15):11877-82.
2001: Chai J; Shiozaki E; Srinivasula S M; Wu Q; Datta P; Alnemri E S; Shi Y;
Structural basis of caspase-7 inhibition by XIAP.
Cell 2001;104(5):769-80.
2001: Srinivasula S M; Hegde R; Saleh A; Datta P; Shiozaki E; Chai J; Lee R A; Robbins P D; Fernandes-Alnemri T; Shi Y; Alnemri E S
A conserved XIAP-interaction motif in caspase-9 and Smac/DIABLO regulates caspase activity and apoptosis.
Nature 2001;410(6824):112-6.
2001: Poyet J L; Srinivasula S M; Alnemri E S
vCLAP, a caspase-recruitment domain-containing protein of equine Herpesvirus-2, persistently activates the Ikappa B kinases through oligomerization of IKKgamma.
The Journal of biological chemistry 2001;276(5):3183-7.
2001: Srinivasula S M; Saleh A; Ahmad M; Fernandes-Alnemri T; Alnemri E S
Isolation and assay of caspases.
Methods in cell biology 2001;66():1-27.
2000: Bertin J; Guo Y; Wang L; Srinivasula S M; Jacobson M D; Poyet J L; Merriam S; Du M Q; Dyer M J; Robison K E; DiStefano P S; Alnemri E S
CARD9 is a novel caspase recruitment domain-containing protein that interacts with BCL10/CLAP and activates NF-kappa B.
The Journal of biological chemistry 2000;275(52):41082-6.
2000: Poyet J L; Srinivasula S M; Lin J H; Fernandes-Alnemri T; Yamaoka S; Tsichlis P N; Alnemri E S
Activation of the Ikappa B kinases by RIP via IKKgamma /NEMO-mediated oligomerization.
The Journal of biological chemistry 2000;275(48):37966-77.
2000: Srinivasula S M; Datta P; Fan X J; Fernandes-Alnemri T; Huang Z; Alnemri E S
Molecular determinants of the caspase-promoting activity of Smac/DIABLO and its role in the death receptor pathway.
The Journal of biological chemistry 2000;275(46):36152-7.
2000: Saleh A; Srinivasula S M; Balkir L; Robbins P D; Alnemri E S
Negative regulation of the Apaf-1 apoptosome by Hsp70.
Nature cell biology 2000;2(8):476-83.
2000: Wang J L; Liu D; Zhang Z J; Shan S; Han X; Srinivasula S M; Croce C M; Alnemri E S; Huang Z
Structure-based discovery of an organic compound that binds Bcl-2 protein and induces apoptosis of tumor cells.
Proceedings of the National Academy of Sciences of the United States of America 2000;97(13):7124-9.
2000: Steplewski A; Ebel W; Planey S L; Alnemri E S; Robertson N M; Litwack G
Phosphorylation of the insect immunophilin FKBP46 by the Spodoptera frugiperda homolog of casein kinase II.
Gene 2000;246(1-2):169-78.
2000: Wang J L; Zhang Z J; Choksi S; Shan S; Lu Z; Croce C M; Alnemri E S; Korngold R; Huang Z
Cell permeable Bcl-2 binding peptides: a chemical approach to apoptosis induction in tumor cells.
Cancer research 2000;60(6):1498-502.
1999: De Maria R; Zeuner A; Eramo A; Domenichelli C; Bonci D; Grignani F; Srinivasula S M; Alnemri E S; Testa U; Peschle C
Negative regulation of erythropoiesis by caspase-mediated cleavage of GATA-1.
Nature 1999;401(6752):489-93.
1999: Wu G S; Burns T F; Zhan Y; Alnemri E S; El-Deiry W S
Molecular cloning and functional analysis of the mouse homologue of the KILLER/DR5 tumor necrosis factor-related apoptosis-inducing ligand (TRAIL) death receptor.
Cancer research 1999;59(12):2770-5.
1999: Qin H; Srinivasula S M; Wu G; Fernandes-Alnemri T; Alnemri E S; Shi Y
Structural basis of procaspase-9 recruitment by the apoptotic protease-activating factor 1.
Nature 1999;399(6736):549-57.
1999: Srinivasula S M; Ahmad M; Lin J H; Poyet J L; Fernandes-Alnemri T; Tsichlis P N; Alnemri E S
CLAP, a novel caspase recruitment domain-containing protein in the tumor necrosis factor receptor pathway, regulates NF-kappaB activation and apoptosis.
The Journal of biological chemistry 1999;274(25):17946-54.
1999: Saleh A; Srinivasula S M; Acharya S; Fishel R; Alnemri E S
Cytochrome c and dATP-mediated oligomerization of Apaf-1 is a prerequisite for procaspase-9 activation.
The Journal of biological chemistry 1999;274(25):17941-5.
1999: Srinivasula S M; Ahmad M; Guo Y; Zhan Y; Lazebnik Y; Fernandes-Alnemri T; Alnemri E S
Identification of an endogenous dominant-negative short isoform of caspase-9 that can regulate apoptosis.
Cancer research 1999;59(5):999-1002.
1999: Kang J J; Schaber M D; Srinivasula S M; Alnemri E S; Litwack G; Hall D J; Bjornsti M A
Cascades of mammalian caspase activation in the yeast Saccharomyces cerevisiae.
The Journal of biological chemistry 1999;274(5):3189-98.
1998: Ahmad M; Srinivasula S M; Hegde R; Mukattash R; Fernandes-Alnemri T; Alnemri E S
Identification and characterization of murine caspase-14, a new member of the caspase family.
Cancer research 1998;58(22):5201-5.
1998: Zhou Q; Krebs J F; Snipas S J; Price A; Alnemri E S; Tomaselli K J; Salvesen G S
Interaction of the baculovirus anti-apoptotic protein p35 with caspases. Specificity, kinetics, and characterization of the caspase/p35 complex.
Biochemistry 1998;37(30):10757-65.
1998: Srinivasula S M; Ahmad M; Fernandes-Alnemri T; Alnemri E S
Autoactivation of procaspase-9 by Apaf-1-mediated oligomerization.
Molecular cell 1998;1(7):949-57.
1998: Resnicoff M; Valentinis B; Herbert D; Abraham D; Friesen P D; Alnemri E S; Baserga R
The baculovirus anti-apoptotic p35 protein promotes transformation of mouse embryo fibroblasts.
The Journal of biological chemistry 1998;273(17):10376-80.
1998: Srinivasula S M; Ahmad M; MacFarlane M; Luo Z; Huang Z; Fernandes-Alnemri T; Alnemri E S
Generation of constitutively active recombinant caspases-3 and -6 by rearrangement of their subunits.
The Journal of biological chemistry 1998;273(17):10107-11.
1998: Hegde R; Srinivasula S M; Ahmad M; Fernandes-Alnemri T; Alnemri E S
Blk, a BH3-containing mouse protein that interacts with Bcl-2 and Bcl-xL, is a potent death agonist.
The Journal of biological chemistry 1998;273(14):7783-6.
1997: MacFarlane M; Ahmad M; Srinivasula S M; Fernandes-Alnemri T; Cohen G M; Alnemri E S
Identification and molecular cloning of two novel receptors for the cytotoxic ligand TRAIL.
The Journal of biological chemistry 1997;272(41):25417-20.
1997: Srinivasula S M; Ahmad M; Ottilie S; Bullrich F; Banks S; Wang Y; Fernandes-Alnemri T; Croce C M; Litwack G; Tomaselli K J; Armstrong R C; Alnemri E S
FLAME-1, a novel FADD-like anti-apoptotic molecule that regulates Fas/TNFR1-induced apoptosis.
The Journal of biological chemistry 1997;272(30):18542-5.
1997: Sullivan W; Stensgard B; Caucutt G; Bartha B; McMahon N; Alnemri E S; Litwack G; Toft D
Nucleotides and two functional states of hsp90.
The Journal of biological chemistry 1997;272(12):8007-12.
1997: Bertin J; Armstrong R C; Ottilie S; Martin D A; Wang Y; Banks S; Wang G H; Senkevich T G; Alnemri E S; Moss B; Lenardo M J; Tomaselli K J; Cohen J I
Death effector domain-containing herpesvirus and poxvirus proteins inhibit both Fas- and TNFR1-induced apoptosis.
Proceedings of the National Academy of Sciences of the United States of America 1997;94(4):1172-6.
1997: Alnemri E S
Mammalian cell death proteases: a family of highly conserved aspartate specific cysteine proteases.
Journal of cellular biochemistry 1997;64(1):33-42.
1997: Robertson N M; Zangrilli J; Fernandes-Alnemri T; Friesen P D; Litwack G; Alnemri E S
Baculovirus P35 inhibits the glucocorticoid-mediated pathway of cell death.
Cancer research 1997;57(1):43-7.
1997: Armstrong R C; Aja T J; Hoang K D; Gaur S; Bai X; Alnemri E S; Litwack G; Karanewsky D S; Fritz L C; Tomaselli K J
Activation of the CED3/ICE-related protease CPP32 in cerebellar granule neurons undergoing apoptosis but not necrosis.
The Journal of neuroscience : the official journal of the Society for Neuroscience 1997;17(2):553-62.
1997: Bruner K L; Derfoul A; Robertson N M; Guerriero G; Fernandes-Alnemri T; Alnemri E S; Litwack G
The unliganded mineralocorticoid receptor is associated with heat shock proteins 70 and 90 and the immunophilin FKBP-52.
Receptors & signal transduction 1997;7(2):85-98.
1996: Srinivasula S M; Ahmad M; Fernandes-Alnemri T; Litwack G; Alnemri E S
Molecular ordering of the Fas-apoptotic pathway: the Fas/APO-1 protease Mch5 is a CrmA-inhibitable protease that activates multiple Ced-3/ICE-like cysteine proteases.
Proceedings of the National Academy of Sciences of the United States of America 1996;93(25):14486-91.
1996: Waterhouse N; Kumar S; Song Q; Strike P; Sparrow L; Dreyfuss G; Alnemri E S; Litwack G; Lavin M; Watters D
Heteronuclear ribonucleoproteins C1 and C2, components of the spliceosome, are specific targets of interleukin 1beta-converting enzyme-like proteases in apoptosis.
The Journal of biological chemistry 1996;271(46):29335-41.
1996: Srinivasula S M; Fernandes-Alnemri T; Zangrilli J; Robertson N; Armstrong R C; Wang L; Trapani J A; Tomaselli K J; Litwack G; Alnemri E S
The Ced-3/interleukin 1beta converting enzyme-like homolog Mch6 and the lamin-cleaving enzyme Mch2alpha are substrates for the apoptotic mediator CPP32.
The Journal of biological chemistry 1996;271(43):27099-106.
1996: Datta R; Banach D; Kojima H; Talanian R V; Alnemri E S; Wong W W; Kufe D W
Activation of the CPP32 protease in apoptosis induced by 1-beta-D-arabinofuranosylcytosine and other DNA-damaging agents.
Blood 1996;88(6):1936-43.
1996: Bullrich F; Fernandes-Alnemri T; Litwack G; Alnemri E S; Croce C M
Chromosomal mapping of cell death proteases CPP32, MCH2, and MCH3.
Genomics 1996;36(2):362-5.
1996: Song Q; Burrows S R; Smith G; Lees-Miller S P; Kumar S; Chan D W; Trapani J A; Alnemri E; Litwack G; Lu H; Moss D J; Jackson S; Lavin M F
Interleukin-1 beta-converting enzyme-like protease cleaves DNA-dependent protein kinase in cytotoxic T cell killing.
The Journal of experimental medicine 1996;184(2):619-26.
1996: Takahashi A; Alnemri E S; Lazebnik Y A; Fernandes-Alnemri T; Litwack G; Moir R D; Goldman R D; Poirier G G; Kaufmann S H; Earnshaw W C
Cleavage of lamin A by Mch2 alpha but not CPP32: multiple interleukin 1 beta-converting enzyme-related proteases with distinct substrate recognition properties are active in apoptosis.
Proceedings of the National Academy of Sciences of the United States of America 1996;93(16):8395-400.
1996: Harvey N L; Trapani J A; Fernandes-Alnemri T; Litwack G; Alnemri E S; Kumar S
Processing of the Nedd2 precursor by ICE-like proteases and granzyme B.
Genes to cells : devoted to molecular & cellular mechanisms 1996;1(7):673-85.
1996: Fernandes-Alnemri T; Armstrong R C; Krebs J; Srinivasula S M; Wang L; Bullrich F; Fritz L C; Trapani J A; Tomaselli K J; Litwack G; Alnemri E S
In vitro activation of CPP32 and Mch3 by Mch4, a novel human apoptotic cysteine protease containing two FADD-like domains.
Proceedings of the National Academy of Sciences of the United States of America 1996;93(15):7464-9.
1996: Song Q; Lees-Miller S P; Kumar S; Zhang Z; Chan D W; Smith G C; Jackson S P; Alnemri E S; Litwack G; Khanna K K; Lavin M F
DNA-dependent protein kinase catalytic subunit: a target for an ICE-like protease in apoptosis.
The EMBO journal 1996;15(13):3238-46.
1995: Fernandes-Alnemri T; Litwack G; Alnemri E S
Mch2, a new member of the apoptotic Ced-3/Ice cysteine protease gene family.
Cancer research 1995;55(13):2737-42.
1995: Alnemri E S; Fernandes-Alnemri T; Litwack G
Cloning and expression of four novel isoforms of human interleukin-1 beta converting enzyme with different apoptotic activities.
The Journal of biological chemistry 1995;270(9):4312-7.
1995: Robertson N M; Bodine P V; Hsu T C; Alnemri E S; Litwack G
Modulator inhibits nuclear translocation of the glucocorticoid receptor and inhibits glucocorticoid-induced apoptosis in the human leukemic cell line CEM C-7.
Cancer research 1995;55(3):548-56.
1995: Bodine P V; Alnemri E S; Litwack G
Synthetic peptides derived from the steroid binding domain block modulator and molybdate action toward the rat glucocorticoid receptor.
Receptor 1995;5(2):117-22.
1994: Fernandes-Alnemri T; Litwack G; Alnemri E S
CPP32, a novel human apoptotic protein with homology to Caenorhabditis elegans cell death protein Ced-3 and mammalian interleukin-1 beta-converting enzyme.
The Journal of biological chemistry 1994;269(49):30761-4.
1994: Alnemri E S; Fernandes-Alnemri T; Pomerenke K; Robertson N M; Dudley K; DuBois G C; Litwack G
FKBP46, a novel Sf9 insect cell nuclear immunophilin that forms a protein-kinase complex.
The Journal of biological chemistry 1994;269(49):30828-34.
1993: Robertson N M; Schulman G; Karnik S; Alnemri E; Litwack G
Demonstration of nuclear translocation of the mineralocorticoid receptor (MR) using an anti-MR antibody and confocal laser scanning microscopy.
Molecular endocrinology (Baltimore, Md.) 1993;7(9):1226-39.
1993: Alnemri E S; Fernandes-Alnemri T; Nelki D S; Dudley K; DuBois G C; Litwack G
Overexpression, characterization, and purification of a recombinant mouse immunophilin FKBP-52 and identification of an associated phosphoprotein.
Proceedings of the National Academy of Sciences of the United States of America 1993;90(14):6839-43.
1993: Alnemri E S; Litwack G
The steroid binding domain influences intracellular solubility of the baculovirus overexpressed glucocorticoid and mineralocorticoid receptors.
Biochemistry 1993;32(20):5387-93.
1992: Alnemri E S; Robertson N M; Fernandes T F; Croce C M; Litwack G
Overexpressed full-length human BCL2 extends the survival of baculovirus-infected Sf9 insect cells.
Proceedings of the National Academy of Sciences of the United States of America 1992;89(16):7295-9.
1992: Alnemri E S; Fernandes T F; Haldar S; Croce C M; Litwack G
Involvement of BCL-2 in glucocorticoid-induced apoptosis of human pre-B-leukemias.
Cancer research 1992;52(2):491-5.
1992: Schulman G; Daniel V; Cooper M; Alnemri E S; Maksymowych A B; Litwack G
Characterization of in vitro translated human mineralocorticoid receptor. Structure and activation.
Receptor 1992;2(3):181-94.
1991: Alnemri E S; Maksymowych A B; Robertson N M; Litwack G
Overexpression and characterization of the human mineralocorticoid receptor.
The Journal of biological chemistry 1991;266(27):18072-81.
1991: Alnemri E S; Maksymowych A B; Robertson N M; Litwack G
Characterization and purification of a functional rat glucocorticoid receptor overexpressed in a baculovirus system.
The Journal of biological chemistry 1991;266(6):3925-36.
1991: Daniel V; Maksymowych A B; Alnemri E S; Litwack G
Cell-free synthesis of rat glucocorticoid receptor in rabbit reticulocyte lysate. In vitro synthesis of receptor in Mr 90,000 heat shock protein-depleted lysate.
The Journal of biological chemistry 1991;266(2):1320-5.
1990: Alnemri E S; Litwack G
Activation of internucleosomal DNA cleavage in human CEM lymphocytes by glucocorticoid and novobiocin. Evidence for a non-Ca2(+)-requiring mechanism(s).
The Journal of biological chemistry 1990;265(28):17323-33.
1989: Alnemri E S; Litwack G
Glucocorticoid-induced lymphocytolysis is not mediated by an induced endonuclease.
The Journal of biological chemistry 1989;264(7):4104-11.

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