FIND

researchers

DISCOVER

relevant articles

PROMOTE

your research

now for free

Emad Alnemri

Research Profile

Chemicals & Drugs

Concepts & Ideas

Co-author Network

Publications

TOP 3
Sujeong Hong; Inhwa Hwang; You-Sun Kim; Won-Keun Lee; Yun-Sun Lee; Sangjun Park; Emad S Alnemri; Teresa Fernandes-Alnemri; Je-Wook Yu
Restoration of ASC expression sensitizes colorectal cancer cells to genotoxic stress-induced caspase-independent cell death.
Je-Wook Yu; Andrew Farias; Teresa Fernandes-Alnemri; Inhwa Hwang; Emad S Alnemri
Ribotoxic Stress through p38 Mitogen-activated Protein Kinase Activates in Vitro the Human Pyrin Inflammasome.
Seokwon Kang; Teresa Fernandes-Alnemri; Emad S Alnemri
A novel role for the mitochondrial HTRA2/OMI protease in aging.

Register for free to view:

Visualized networks:

See your personal network in
sophisticated graphical views

GeoTargeted Searches:

Locate experts around the world
and connect with global collaborators

Research Profiles:

See the research activity
of experts around the globe

Geonetwork of Emad Alnemri (preview)

Cities where this author has publications
Cities where co-authors of this author have publications

Flash Player Required

All Publications

2013: Sujeong Hong; Inhwa Hwang; You-Sun Kim; Won-Keun Lee; Yun-Sun Lee; Sangjun Park; Emad S Alnemri; Teresa Fernandes-Alnemri; Je-Wook Yu
Restoration of ASC expression sensitizes colorectal cancer cells to genotoxic stress-induced caspase-independent cell death.
Cancer letters 2013;331(2):183-91.
2013: Je-Wook Yu; Andrew Farias; Teresa Fernandes-Alnemri; Inhwa Hwang; Emad S Alnemri
Ribotoxic Stress through p38 Mitogen-activated Protein Kinase Activates in Vitro the Human Pyrin Inflammasome.
The Journal of biological chemistry 2013;288(16):11378-83.
2013: Seokwon Kang; Teresa Fernandes-Alnemri; Emad S Alnemri
A novel role for the mitochondrial HTRA2/OMI protease in aging.
Autophagy 2013;9(3):420-1.
2013: S Kang; C P Landel; J-P Louboutin; D Martinez; D S Strayer; Antonis S Zervos; Pinaki Datta; Teresa Fernandes-Alnemri; Emad S Alnemri
Loss of HtrA2/Omi activity in non-neuronal tissues of adult mice causes premature aging.
Cell death and differentiation 2013;20(2):259-69.
2012: Yoshifumi Hashimoto; Emad S Alnemri; Pinaki Datta; Nao Hosoda; Shin-Ichi Hoshino
Translation termination factor eRF3 is targeted for caspase-mediated proteolytic cleavage and degradation during DNA damage-induced apoptosis.
Apoptosis : an international journal on programmed cell death 2012;17(12):1287-99.
2012: Christine Juliana; Seokwon Kang; Fengsong Qin; Andrew Farias; Teresa Fernandes-Alnemri; Emad S Alnemri
Non-transcriptional priming and deubiquitination regulate NLRP3 inflammasome activation.
The Journal of biological chemistry 2012;287(43):36617-22.
2011: Rendong Fang; Teresa Fernandes-Alnemri; Hideki Hara; Eduardo Hernandez-Cuellar; Ikuo Kawamura; Huixin Qu; Shunsuke Sakai; Yanna Shen; Kohsuke Tsuchiya; Yanting Xu; Takeshi Yamamoto; Ruili Yang; Emad S Alnemri; Sita R Dewamitta; Masao Mitsuyama
Critical roles of ASC inflammasomes in caspase-1 activation and host innate resistance to Streptococcus pneumoniae infection.
Journal of immunology (Baltimore, Md. : 1950) 2011;187(9):4890-9.
2010: Tyler K Ulland; Blake W Buchan; Margaret R Ketterer; Teresa Fernandes-Alnemri; David K Meyerholz; Michael A Apicella; Emad S Alnemri; Bradley D Jones; William M Nauseef; Fayyaz S Sutterwala
Cutting edge: mutation of Francisella tularensis mviN leads to increased macrophage absent in melanoma 2 inflammasome activation and a loss of virulence.
Journal of immunology (Baltimore, Md. : 1950) 2010;185(5):2670-4.
2010: Jianghong Wu; Teresa Fernandes-Alnemri; Emad S Alnemri
Involvement of the AIM2, NLRC4, and NLRP3 inflammasomes in caspase-1 activation by Listeria monocytogenes.
Journal of clinical immunology 2010;30(5):693-702.
2010: Emad S Alnemri
Sensing cytoplasmic danger signals by the inflammasome.
Journal of clinical immunology 2010;30(4):512-9.
2010: Teresa Fernandes-Alnemri; Je-Wook Yu; Christine Juliana; Leobaldo Solorzano; Seokwon Kang; Jianghong Wu; Pinaki Datta; Margaret McCormick; Lan Huang; Erin McDermott; Laurence C Eisenlohr; Carlisle P Landel; Emad S Alnemri
The AIM2 inflammasome is critical for innate immunity to Francisella tularensis.
Nature immunology 2010;11(5):385-93.
2010: Isabelle Jéru; Sandrine Marlin; Gaëlle Le Borgne; Emmanuelle Cochet; Sylvain Normand; Philippe Duquesnoy; Florence Dastot-Le Moal; Laurence Cuisset; Véronique Hentgen; Teresa Fernandes-Alnemri; Jean-Claude Lecron; Robin Dhote; Gilles Grateau; Emad S Alnemri; Serge Amselem
Functional consequences of a germline mutation in the leucine-rich repeat domain of NLRP3 identified in an atypical autoinflammatory disorder.
Arthritis and rheumatism 2010;62(4):1176-85.
2010: Christine Juliana; Teresa Fernandes-Alnemri; Jianghong Wu; Pinaki Datta; Leobaldo Solorzano; Je-Wook Yu; Rong Meng; Andrew A Quong; Eicke Latz; Charles P Scott; Emad S Alnemri
Anti-inflammatory compounds parthenolide and Bay 11-7082 are direct inhibitors of the inflammasome.
The Journal of biological chemistry 2010;285(13):9792-802.
2009: Meenakshi P Balakrishnan; Lucia Cilenti; Zineb Mashak; Paiyal Popat; Emad S Alnemri; Antonis S Zervos
THAP5 is a human cardiac-specific inhibitor of cell cycle that is cleaved by the proapoptotic Omi/HtrA2 protease during cell death.
American journal of physiology. Heart and circulatory physiology 2009;297(2):H643-53.
2009: Franz G Bauernfeind; Gabor Horvath; Andrea Stutz; Emad S Alnemri; Kelly MacDonald; David Speert; Teresa Fernandes-Alnemri; Jianghong Wu; Brian G Monks; Katherine A Fitzgerald; Veit Hornung; Eicke Latz
Cutting edge: NF-kappaB activating pattern recognition and cytokine receptors license NLRP3 inflammasome activation by regulating NLRP3 expression.
Journal of immunology (Baltimore, Md. : 1950) 2009;183(2):787-91.
2009: Teresa Fernandes-Alnemri; Je-Wook Yu; Pinaki Datta; Jianghong Wu; Emad S Alnemri
AIM2 activates the inflammasome and cell death in response to cytoplasmic DNA.
Nature 2009;458(7237):509-13.
2008: Taner Dogan; Gregory S Harms; Mirko Hekman; Christiaan Karreman; Tripat Kaur Oberoi; Emad S Alnemri; Ulf R Rapp; Krishnaraj Rajalingam
X-linked and cellular IAPs modulate the stability of C-RAF kinase and cell motility.
Nature cell biology 2008;10(12):1447-55.
2008: Farhan Khan; Miki Fujioka; Pinaki Datta; Teresa Fernandes-Alnemri; James B Jaynes; Emad S Alnemri
The interaction of DIAP1 with dOmi/HtrA2 regulates cell death in Drosophila.
Cell death and differentiation 2008;15(6):1073-83.
2008: Jenny P-Y Ting; Ruth C Lovering; Emad S Alnemri; John Bertin; Jeremy M Boss; Beckley K Davis; Richard A Flavell; Stephen E Girardin; Adam Godzik; Jonathan A Harton; Hal M Hoffman; Jean-Pierre Hugot; Naohiro Inohara; Alex Mackenzie; Lois J Maltais; Gabriel Nunez; Yasunori Ogura; Luc A Otten; Dana Philpott; John C Reed; Walter Reith; Stefan Schreiber; Viktor Steimle; Peter A Ward
The NLR gene family: a standard nomenclature.
Immunity 2008;28(3):285-7.
2008: Isabelle Jéru; Philippe Duquesnoy; Teresa Fernandes-Alnemri; E Cochet; Je-Wook Yu; M Lackmy-Port-Lis; Emmanuel Grimprel; J Landman-Parker; Véronique Hentgen; Sandrine Marlin; K McElreavey; Tamara Sarkisian; Gilles Grateau; Emad S Alnemri; Serge Amselem
Mutations in NALP12 cause hereditary periodic fever syndromes.
Proceedings of the National Academy of Sciences of the United States of America 2008;105(5):1614-9.
2008: Teresa Fernandes-Alnemri; Emad S Alnemri
Assembly, purification, and assay of the activity of the ASC pyroptosome.
Methods in enzymology 2008;442():251-70.
2007: Emad S Alnemri
HtrA2 and Parkinson's disease: think PINK?
Nature cell biology 2007;9(11):1227-9.
2007: Je-Wook Yu; Teresa Fernandes-Alnemri; Pinaki Datta; Jianghong Wu; Christine Juliana; Leobaldo Solorzano; Margaret McCormick; ZhiJia Zhang; Emad S Alnemri
Pyrin activates the ASC pyroptosome in response to engagement by autoinflammatory PSTPIP1 mutants.
Molecular cell 2007;28(2):214-27.
2007: Teresa Fernandes-Alnemri; Jianghong Wu; Je-Wook Yu; Pinaki Datta; B Miller; W Jankowski; S Rosenberg; J Zhang; Emad S Alnemri
The pyroptosome: a supramolecular assembly of ASC dimers mediating inflammatory cell death via caspase-1 activation.
Cell death and differentiation 2007;14(9):1590-604.
2006: Je-Wook Yu; Jianghong Wu; ZhiJia Zhang; Pinaki Datta; I Ibrahimi; S Taniguchi; J Sagara; Teresa Fernandes-Alnemri; Emad S Alnemri
Cryopyrin and pyrin activate caspase-1, but not NF-kappaB, via ASC oligomerization.
Cell death and differentiation 2006;13(2):236-49.
2005: Lucia Cilenti; George A Kyriazis; Mangala M Soundarapandian; Valerie Stratico; Adam Yerkes; Kwon Moo Park; Alice M Sheridan; Emad S Alnemri; Joseph V Bonventre; Antonis S Zervos
Omi/HtrA2 protease mediates cisplatin-induced cell death in renal cells.
American journal of physiology. Renal physiology 2005;288(2):F371-9.
2005: Hui-Rong Liu; Erhe Gao; Aihua Hu; Ling Tao; Yan Qu; Patrick Most; Walter J Koch; Theodore A Christopher; Bernard L Lopez; Emad S Alnemri; Antonis S Zervos; Xin L Ma
Role of Omi/HtrA2 in apoptotic cell death after myocardial ischemia and reperfusion.
Circulation 2005;111(1):90-6.
2004: Lucia Cilenti; Mangala M Soundarapandian; George A Kyriazis; Valerie Stratico; Supriya Singh; Sanjeev Gupta; Joseph V Bonventre; Emad S Alnemri; Antonis S Zervos
Regulation of HAX-1 anti-apoptotic protein by Omi/HtrA2 protease during cell death.
The Journal of biological chemistry 2004;279(48):50295-301.
2004: Sanjeev Gupta; Rajesh Singh; Pinaki Datta; Zhijia Zhang; Christopher Orr; Zhixian Lu; Garrett C DuBois; Antonis S Zervos; Miriam H Meisler; Srinivasa M Srinivasula; Teresa Fernandes-Alnemri; Emad S Alnemri
The C-terminal tail of presenilin regulates Omi/HtrA2 protease activity.
The Journal of biological chemistry 2004;279(44):45844-54.
2004: Yin Guo; NaEun Cheong; ZhiJia Zhang; Robert De Rose; Yun Deng; Steven A Farber; Teresa Fernandes-Alnemri; Emad S Alnemri
Tim50, a component of the mitochondrial translocator, regulates mitochondrial integrity and cell death.
The Journal of biological chemistry 2004;279(23):24813-25.
2004: Maya Saleh; John P Vaillancourt; Graham Kyrenia Rona; Matthew Huyck; Srinivasa M Srinivasula; Emad S Alnemri; Martin H Steinberg; Vikki G Nolan; Clinton T Baldwin; Richard S Hotchkiss; Timothy G Buchman; Barbara A Zehnbauer; Michael R Hayden; Lindsay A Farrer; Sophie Roy; Donald W Nicholson
Differential modulation of endotoxin responsiveness by human caspase-12 polymorphisms.
Nature 2004;429(6987):75-9.
2003: Julie M Jones; Pinaki Datta; Srinivasa M Srinivasula; Weizhen Ji; Sanjeev Gupta; ZhiJia Zhang; Erika Davies; Gyorgy Hajn\u2264czky; Thomas L Saunders; Margaret L Van Keuren; Teresa Fernandes-Alnemri; Miriam H Meisler; Emad S Alnemri
Loss of Omi mitochondrial protease activity causes the neuromuscular disorder of mnd2 mutant mice.
Nature 2003;425(6959):721-7.
2003: Ramesh Hegde; Srinivasa M Srinivasula; Pinaki Datta; Muniswamy Madesh; Richard Wassell; ZhiJia Zhang; NaEun Cheong; julie nijmeh; Teresa Fernandes-Alnemri; Shin-ichi Hoshino; Emad S Alnemri
The polypeptide chain-releasing factor GSPT1/eRF3 is proteolytically processed into an IAP-binding protein.
The Journal of biological chemistry 2003;278(40):38699-706.
2003: Srinivasa M Srinivasula; Sanjeev Gupta; Pinaki Datta; ZhiJia Zhang; Ramesh Hegde; NaEun Cheong; Teresa Fernandes-Alnemri; Emad S Alnemri
Inhibitor of apoptosis proteins are substrates for the mitochondrial serine protease Omi/HtrA2.
The Journal of biological chemistry 2003;278(34):31469-72.
2003: Ann Zeuner; Adriana Eramo; Ugo Testa; Nadia Felli; Elvira Pelosi; Gualtiero Mariani; Srinivasa M Srinivasula; Emad S Alnemri; Gianluigi Condorelli; Cesare Peschle; Ruggero De Maria
Control of erythroid cell production via caspase-mediated cleavage of transcription factor SCL/Tal-1.
Cell death and differentiation 2003;10(8):905-13.
2003: David W Chang; Dara Ditsworth; Hongtu Liu; Srinivasa M Srinivasula; Emad S Alnemri; Xiaolu Yang
Oligomerization is a general mechanism for the activation of apoptosis initiator and inflammatory procaspases.
The Journal of biological chemistry 2003;278(19):16466-9.
2003: Karthikeyan Kandasamy; Srinivasa M Srinivasula; Emad S Alnemri; Craig Thompson; Stanley J Korsmeyer; Joseph L Bryant; Rakesh K Srivastava
Involvement of proapoptotic molecules Bax and Bak in tumor necrosis factor-related apoptosis-inducing ligand (TRAIL)-induced mitochondrial disruption and apoptosis: differential regulation of cytochrome c and Smac/DIABLO release.
Cancer research 2003;63(7):1712-21.
2003: Lucia Cilenti; Younghee Lee; Sibylle Hess; Srinivasa M Srinivasula; Kwon Moo Park; Daniela Junqueira; Hedvika Davis; Joseph V Bonventre; Emad S Alnemri; Antonis S Zervos
Characterization of a novel and specific inhibitor for the pro-apoptotic protease Omi/HtrA2.
The Journal of biological chemistry 2003;278(13):11489-94.
2003: Li Jia; Yasmeen Patwari; Stephen M Kelsey; Srinivasa M Srinivasula; Samir G Agrawal; Emad S Alnemri; Adrian C Newland
Role of Smac in human leukaemic cell apoptosis and proliferation.
Oncogene 2003;22(11):1589-99.
2003: Eric N Shiozaki; Jijie Chai; Daniel J Rigotti; Stefan J Riedl; Pingwei Li; Srinivasa M Srinivasula; Emad S Alnemri; Robert Fairman; Yigong Shi
Mechanism of XIAP-mediated inhibition of caspase-9.
Molecular cell 2003;11(2):519-27.
2002: G Pistritto; Monika Jost; Srinivasa M Srinivasula; Raffaele Baffa; Jean-Luc Poyet; Csaba Kari; Yuri Lazebnik; Ulrich Rodeck; Emad S Alnemri
Expression and transcriptional regulation of caspase-14 in simple and complex epithelia.
Cell death and differentiation 2002;9(9):995-1006.
2002: Srinivasa M Srinivasula; Jean-Luc Poyet; Marjaneh Razmara; Pinaki Datta; ZhiJia Zhang; Emad S Alnemri
The PYRIN-CARD protein ASC is an activating adaptor for caspase-1.
The Journal of biological chemistry 2002;277(24):21119-22.
2002: Wenyu Li; Srinivasa M Srinivasula; Jijie Chai; Pingwei Li; Jia-Wei Wu; ZhiJia Zhang; Emad S Alnemri; Yigong Shi
Structural insights into the pro-apoptotic function of mitochondrial serine protease HtrA2/Omi.
Nature structural biology 2002;9(6):436-41.
2002: Yin Guo; Srinivasa M Srinivasula; Anne Druilhe; Teresa Fernandes-Alnemri; Emad S Alnemri
Caspase-2 induces apoptosis by releasing proapoptotic proteins from mitochondria.
The Journal of biological chemistry 2002;277(16):13430-7.
2002: Marjaneh Razmara; Srinivasa M Srinivasula; Lin Wang; Jean-Luc Poyet; Brad J Geddes; Peter S DiStefano; John Bertin; Emad S Alnemri
CARD-8 protein, a new CARD family member that regulates caspase-1 activation and apoptosis.
The Journal of biological chemistry 2002;277(16):13952-8.
2002: Y Zhan; Ramesh Hegde; Srinivasa M Srinivasula; Teresa Fernandes-Alnemri; Emad S Alnemri
Death effector domain-containing proteins DEDD and FLAME-3 form nuclear complexes with the TFIIIC102 subunit of human transcription factor IIIC.
Cell death and differentiation 2002;9(4):439-47.
2002: Muniswamy Madesh; Bruno Antonsson; Srinivasa M Srinivasula; Emad S Alnemri; Gyorgy Hajn\u2264czky
Rapid kinetics of tBid-induced cytochrome c and Smac/DIABLO release and mitochondrial depolarization.
The Journal of biological chemistry 2002;277(7):5651-9.
2002: Srinivasa M Srinivasula; Pinaki Datta; Masatomo Kobayashi; Jia Wei Wu; Miki Fujioka; Ramesh Hegde; ZhiJia Zhang; Rula Mukattash; Teresa Fernandes-Alnemri; Yigong Shi; James B Jaynes; Emad S Alnemri
sickle, a novel Drosophila death gene in the reaper/hid/grim region, encodes an IAP-inhibitory protein.
Current biology : CB 2002;12(2):125-30.
2002: Ramesh Hegde; Srinivasa M Srinivasula; ZhiJia Zhang; Richard Wassell; Rula Mukattash; Lucia Cilenti; Garrett C DuBois; Yuri Lazebnik; Antonis S Zervos; Teresa Fernandes-Alnemri; Emad S Alnemri
Identification of Omi/HtrA2 as a mitochondrial apoptotic serine protease that disrupts inhibitor of apoptosis protein-caspase interaction.
The Journal of biological chemistry 2002;277(1):432-8.
2001: Jijie Chai; Q Wu; Eric N Shiozaki; Srinivasa M Srinivasula; Emad S Alnemri; Yigong Shi
Crystal structure of a procaspase-7 zymogen: mechanisms of activation and substrate binding.
Cell 2001;107(3):399-407.
2001: Li Jia; Yasmeen Patwari; Srinivasa M Srinivasula; Adrian C Newland; Teresa Fernandes-Alnemri; Emad S Alnemri; Stephen M Kelsey
Bax translocation is crucial for the sensitivity of leukaemic cells to etoposide-induced apoptosis.
Oncogene 2001;20(35):4817-26.
2001: Jean-Luc Poyet; Srinivasa M Srinivasula; Mehdi Tnani; Marjaneh Razmara; Teresa Fernandes-Alnemri; Emad S Alnemri
Identification of Ipaf, a human caspase-1-activating protein related to Apaf-1.
The Journal of biological chemistry 2001;276(30):28309-13.
2001: Lin Wang; Y Guo; Waan-Jeng Huang; X Ke; Jean-Luc Poyet; Gulam Manji; Sarah Merriam; MA Glucksmann; Peter S DiStefano; Emad S Alnemri; John Bertin
Card10 is a novel caspase recruitment domain/membrane-associated guanylate kinase family member that interacts with BCL10 and activates NF-kappa B.
The Journal of biological chemistry 2001;276(24):21405-9.
2001: A Druilhe; Srinivasa M Srinivasula; Marjaneh Razmara; M Ahmad; Emad S Alnemri
Regulation of IL-1beta generation by Pseudo-ICE and ICEBERG, two dominant negative caspase recruitment domain proteins.
Cell death and differentiation 2001;8(6):649-57.
2001: Fabrizio Condorelli; P Salomoni; S Cotteret; Vincenzo Cesi; Srinivasa M Srinivasula; Emad S Alnemri; Bruno Calabretta
Caspase cleavage enhances the apoptosis-inducing effects of BAD.
Molecular and cellular biology 2001;21(9):3025-36.
2001: John Bertin; Lin Wang; Y Guo; Michael D Jacobson; Jean-Luc Poyet; Srinivasa M Srinivasula; Sarah Merriam; Peter S DiStefano; Emad S Alnemri
CARD11 and CARD14 are novel caspase recruitment domain (CARD)/membrane-associated guanylate kinase (MAGUK) family members that interact with BCL10 and activate NF-kappa B.
The Journal of biological chemistry 2001;276(15):11877-82.
2001: Jijie Chai; Eric N Shiozaki; Srinivasa M Srinivasula; Q Wu; Pinaki Datta; Emad S Alnemri; Yigong Shi; P Dataa
Structural basis of caspase-7 inhibition by XIAP.
Cell 2001;104(5):769-80.
2001: Srinivasa M Srinivasula; Ramesh Hegde; A Saleh; Pinaki Datta; Eric N Shiozaki; Jijie Chai; R A Lee; P D Robbins; Teresa Fernandes-Alnemri; Yigong Shi; Emad S Alnemri
A conserved XIAP-interaction motif in caspase-9 and Smac/DIABLO regulates caspase activity and apoptosis.
Nature 2001;410(6824):112-6.
2001: Jean-Luc Poyet; Srinivasa M Srinivasula; Emad S Alnemri
vCLAP, a caspase-recruitment domain-containing protein of equine Herpesvirus-2, persistently activates the Ikappa B kinases through oligomerization of IKKgamma.
The Journal of biological chemistry 2001;276(5):3183-7.
2001: Srinivasa M Srinivasula; A Saleh; M Ahmad; Teresa Fernandes-Alnemri; Emad S Alnemri
Isolation and assay of caspases.
Methods in cell biology 2001;66():1-27.
2000: John Bertin; Y Guo; Lin Wang; Srinivasa M Srinivasula; Michael D Jacobson; Jean-Luc Poyet; Sarah Merriam; M Q Du; M J Dyer; K E Robison; Peter S DiStefano; Emad S Alnemri
CARD9 is a novel caspase recruitment domain-containing protein that interacts with BCL10/CLAP and activates NF-kappa B.
The Journal of biological chemistry 2000;275(52):41082-6.
2000: Jean-Luc Poyet; Srinivasa M Srinivasula; Jun-Hsiang Lin; Teresa Fernandes-Alnemri; S Yamaoka; Philip Tsichlis; Emad S Alnemri
Activation of the Ikappa B kinases by RIP via IKKgamma /NEMO-mediated oligomerization.
The Journal of biological chemistry 2000;275(48):37966-77.
2000: Srinivasa M Srinivasula; Pinaki Datta; X J Fan; Teresa Fernandes-Alnemri; Ziwei Huang; Emad S Alnemri
Molecular determinants of the caspase-promoting activity of Smac/DIABLO and its role in the death receptor pathway.
The Journal of biological chemistry 2000;275(46):36152-7.
2000: A Saleh; Srinivasa M Srinivasula; L Balkir; P D Robbins; Emad S Alnemri
Negative regulation of the Apaf-1 apoptosome by Hsp70.
Nature cell biology 2000;2(8):476-83.
2000: J L Wang; D Liu; Z J Zhang; S Shan; X Han; S M Srinivasula; Carlo M Croce; Emad S Alnemri; Ziwei Huang
Structure-based discovery of an organic compound that binds Bcl-2 protein and induces apoptosis of tumor cells.
Proceedings of the National Academy of Sciences of the United States of America 2000;97(13):7124-9.
2000: Andrzej Steplewski; W Ebel; Sonia L Planey; Emad S Alnemri; Noreen M Robertson; Gerald Litwack
Phosphorylation of the insect immunophilin FKBP46 by the Spodoptera frugiperda homolog of casein kinase II.
Gene 2000;246(1-2):169-78.
2000: J L Wang; Z J Zhang; Swati Choksi; S Shan; Z Lu; Carlo M Croce; Emad S Alnemri; Robert Korngold; Ziwei Huang
Cell permeable Bcl-2 binding peptides: a chemical approach to apoptosis induction in tumor cells.
Cancer research 2000;60(6):1498-502.
1999: Ruggero De Maria; Ann Zeuner; Adriana Eramo; C Domenichelli; Désirée Bonci; Francesco Grignani; Srinivasa M Srinivasula; Emad S Alnemri; Ugo Testa; Cesare Peschle
Negative regulation of erythropoiesis by caspase-mediated cleavage of GATA-1.
Nature 1999;401(6752):489-93.
1999: Srinivasa M Srinivasula; M Ahmad; Jun-Hsiang Lin; Jean-Luc Poyet; Teresa Fernandes-Alnemri; Philip Tsichlis; Emad S Alnemri
CLAP, a novel caspase recruitment domain-containing protein in the tumor necrosis factor receptor pathway, regulates NF-kappaB activation and apoptosis.
The Journal of biological chemistry 1999;274(25):17946-54.
1999: A Saleh; Srinivasa M Srinivasula; Samir Acharya; Richard Fishel; Emad S Alnemri
Cytochrome c and dATP-mediated oligomerization of Apaf-1 is a prerequisite for procaspase-9 activation.
The Journal of biological chemistry 1999;274(25):17941-5.
1999: Gen Sheng Wu; Timothy F Burns; Yi Zhan; Emad S Alnemri; Wafik S El-Deiry
Molecular cloning and functional analysis of the mouse homologue of the KILLER/DR5 tumor necrosis factor-related apoptosis-inducing ligand (TRAIL) death receptor.
Cancer research 1999;59(12):2770-5.
1999: H Qin; Srinivasa M Srinivasula; G Wu; Teresa Fernandes-Alnemri; Emad S Alnemri; Yigong Shi
Structural basis of procaspase-9 recruitment by the apoptotic protease-activating factor 1.
Nature 1999;399(6736):549-57.
1999: Srinivasa M Srinivasula; M Ahmad; Yin Guo; Y Zhan; Yuri Lazebnik; Teresa Fernandes-Alnemri; Emad S Alnemri
Identification of an endogenous dominant-negative short isoform of caspase-9 that can regulate apoptosis.
Cancer research 1999;59(5):999-1002.
1999: J J Kang; M D Schaber; Srinivasa M Srinivasula; Emad S Alnemri; Gerald Litwack; David J Hall; Mary-Ann Bjornsti
Cascades of mammalian caspase activation in the yeast Saccharomyces cerevisiae.
The Journal of biological chemistry 1999;274(5):3189-98.
1998: M Ahmad; Srinivasa M Srinivasula; Ramesh Hegde; Rula Mukattash; Teresa Fernandes-Alnemri; Emad S Alnemri
Identification and characterization of murine caspase-14, a new member of the caspase family.
Cancer research 1998;58(22):5201-5.
1998: Qiao Zhou; JF Krebs; S J Snipas; A Price; Emad S Alnemri; Kevin J Tomaselli; G S Salvesen
Interaction of the baculovirus anti-apoptotic protein p35 with caspases. Specificity, kinetics, and characterization of the caspase/p35 complex.
Biochemistry 1998;37(30):10757-65.
1998: Srinivasa M Srinivasula; M Ahmad; Teresa Fernandes-Alnemri; Emad S Alnemri
Autoactivation of procaspase-9 by Apaf-1-mediated oligomerization.
Molecular cell 1998;1(7):949-57.
1998: Mariana Resnicoff; B Valentinis; D Herbert; D Abraham; P D Friesen; Emad S Alnemri; Renato Baserga
The baculovirus anti-apoptotic p35 protein promotes transformation of mouse embryo fibroblasts.
The Journal of biological chemistry 1998;273(17):10376-80.
1998: Srinivasa M Srinivasula; M Ahmad; M MacFarlane; Zhaowen Luo; Ziwei Huang; Teresa Fernandes-Alnemri; Emad S Alnemri
Generation of constitutively active recombinant caspases-3 and -6 by rearrangement of their subunits.
The Journal of biological chemistry 1998;273(17):10107-11.
1998: Ramesh Hegde; Srinivasa M Srinivasula; M Ahmad; Teresa Fernandes-Alnemri; Emad S Alnemri
Blk, a BH3-containing mouse protein that interacts with Bcl-2 and Bcl-xL, is a potent death agonist.
The Journal of biological chemistry 1998;273(14):7783-6.
1997: M MacFarlane; M Ahmad; Srinivasa M Srinivasula; Teresa Fernandes-Alnemri; G M Cohen; Emad S Alnemri
Identification and molecular cloning of two novel receptors for the cytotoxic ligand TRAIL.
The Journal of biological chemistry 1997;272(41):25417-20.
1997: Srinivasa M Srinivasula; M Ahmad; S Ottilie; Florencia Bullrich; S Banks; Youli Wang; Teresa Fernandes-Alnemri; Carlo M Croce; Gerald Litwack; Kevin J Tomaselli; Robert C Armstrong; Emad S Alnemri
FLAME-1, a novel FADD-like anti-apoptotic molecule that regulates Fas/TNFR1-induced apoptosis.
The Journal of biological chemistry 1997;272(30):18542-5.
1997: William Sullivan; Bridget Stensgard; G Caucutt; B Bartha; N McMahon; Emad S Alnemri; G Litwack; David O Toft
Nucleotides and two functional states of hsp90.
The Journal of biological chemistry 1997;272(12):8007-12.
1997: John Bertin; Robert C Armstrong; S Ottilie; DA Martin; Youli Wang; S Banks; GH Wang; T G Senkevich; Emad S Alnemri; Bernard Moss; Michael J Lenardo; Kevin J Tomaselli; Jeffrey I Cohen
Death effector domain-containing herpesvirus and poxvirus proteins inhibit both Fas- and TNFR1-induced apoptosis.
Proceedings of the National Academy of Sciences of the United States of America 1997;94(4):1172-6.
1997: Robert C Armstrong; Teresa Aja; K D Hoang; S Gaur; X Bai; Emad S Alnemri; Gerald Litwack; Donald S Karanewsky; Lawrence C Fritz; Kevin J Tomaselli
Activation of the CED3/ICE-related protease CPP32 in cerebellar granule neurons undergoing apoptosis but not necrosis.
The Journal of neuroscience : the official journal of the Society for Neuroscience 1997;17(2):553-62.
1997: K L Bruner; Assia Derfoul; Noreen M Robertson; G Guerriero; Teresa Fernandes-Alnemri; Emad S Alnemri; Gerald Litwack
The unliganded mineralocorticoid receptor is associated with heat shock proteins 70 and 90 and the immunophilin FKBP-52.
Receptors & signal transduction 1997;7(2):85-98.
1997: Emad S Alnemri
Mammalian cell death proteases: a family of highly conserved aspartate specific cysteine proteases.
Journal of cellular biochemistry 1997;64(1):33-42.
1997: Noreen M Robertson; James G Zangrilli; Teresa Fernandes-Alnemri; P D Friesen; Gerald Litwack; Emad S Alnemri
Baculovirus P35 inhibits the glucocorticoid-mediated pathway of cell death.
Cancer research 1997;57(1):43-7.
1996: Srinivasa M Srinivasula; M Ahmad; Teresa Fernandes-Alnemri; Gerald Litwack; Emad S Alnemri
Molecular ordering of the Fas-apoptotic pathway: the Fas/APO-1 protease Mch5 is a CrmA-inhibitable protease that activates multiple Ced-3/ICE-like cysteine proteases.
Proceedings of the National Academy of Sciences of the United States of America 1996;93(25):14486-91.
1996: Nigel Waterhouse; Sharad Kumar; Q Song; P Strike; L Sparrow; G Dreyfuss; Emad S Alnemri; G Litwack; Martin Lavin; Dianne Watters
Heteronuclear ribonucleoproteins C1 and C2, components of the spliceosome, are specific targets of interleukin 1beta-converting enzyme-like proteases in apoptosis.
The Journal of biological chemistry 1996;271(46):29335-41.
1996: Srinivasa M Srinivasula; Teresa Fernandes-Alnemri; James G Zangrilli; N Robertson; Robert C Armstrong; L Wang; J A Trapani; Kevin J Tomaselli; Gerald Litwack; Emad S Alnemri
The Ced-3/interleukin 1beta converting enzyme-like homolog Mch6 and the lamin-cleaving enzyme Mch2alpha are substrates for the apoptotic mediator CPP32.
The Journal of biological chemistry 1996;271(43):27099-106.
1996: Rakesh Datta; D Banach; H Kojima; Robert Talanian; Emad S Alnemri; Winnie W Wong; Donald Kufe
Activation of the CPP32 protease in apoptosis induced by 1-beta-D-arabinofuranosylcytosine and other DNA-damaging agents.
Blood 1996;88(6):1936-43.
1996: Florencia Bullrich; Teresa Fernandes-Alnemri; Gerald Litwack; Emad S Alnemri; Carlo M Croce
Chromosomal mapping of cell death proteases CPP32, MCH2, and MCH3.
Genomics 1996;36(2):362-5.
1996: A Takahashi; Emad S Alnemri; Y A Lazebnik; Teresa Fernandes-Alnemri; G Litwack; Robert D. Moir; R D Goldman; G G Poirier; Scott H Kaufmann; William C Earnshaw
Cleavage of lamin A by Mch2 alpha but not CPP32: multiple interleukin 1 beta-converting enzyme-related proteases with distinct substrate recognition properties are active in apoptosis.
Proceedings of the National Academy of Sciences of the United States of America 1996;93(16):8395-400.
1996: Q Song; Scott R Burrows; G Smith; Susan Lees-Miller; Sharad Kumar; D W Chan; J A Trapani; Emad S Alnemri; G Litwack; H Lu; Denis Moss; S Jackson; Martin F Lavin
Interleukin-1 beta-converting enzyme-like protease cleaves DNA-dependent protein kinase in cytotoxic T cell killing.
The Journal of experimental medicine 1996;184(2):619-26.
1996: Teresa Fernandes-Alnemri; Robert C Armstrong; J Krebs; Srinivasa M Srinivasula; L Wang; Florencia Bullrich; Lawrence C Fritz; J A Trapani; Kevin J Tomaselli; Gerald Litwack; Emad S Alnemri
In vitro activation of CPP32 and Mch3 by Mch4, a novel human apoptotic cysteine protease containing two FADD-like domains.
Proceedings of the National Academy of Sciences of the United States of America 1996;93(15):7464-9.
1996: NL Harvey; J A Trapani; Teresa Fernandes-Alnemri; G Litwack; Emad S Alnemri; Sharad Kumar
Processing of the Nedd2 precursor by ICE-like proteases and granzyme B.
Genes to cells : devoted to molecular & cellular mechanisms 1996;1(7):673-85.
1996: Q Song; Susan Lees-Miller; Sharad Kumar; Z Zhang; D W Chan; G C Smith; S P Jackson; Emad S Alnemri; G Litwack; Kum Kum Khanna; Martin F Lavin
DNA-dependent protein kinase catalytic subunit: a target for an ICE-like protease in apoptosis.
The EMBO journal 1996;15(13):3238-46.
1995: Teresa Fernandes-Alnemri; Gerald Litwack; Emad S Alnemri
Mch2, a new member of the apoptotic Ced-3/Ice cysteine protease gene family.
Cancer research 1995;55(13):2737-42.
1995: Emad S Alnemri; Teresa Fernandes-Alnemri; Gerald Litwack
Cloning and expression of four novel isoforms of human interleukin-1 beta converting enzyme with different apoptotic activities.
The Journal of biological chemistry 1995;270(9):4312-7.
1995: Noreen M Robertson; Peter V N Bodine; T C Hsu; Emad S Alnemri; Gerald Litwack
Modulator inhibits nuclear translocation of the glucocorticoid receptor and inhibits glucocorticoid-induced apoptosis in the human leukemic cell line CEM C-7.
Cancer research 1995;55(3):548-56.
1995: Peter V N Bodine; Emad S Alnemri; Gerald Litwack
Synthetic peptides derived from the steroid binding domain block modulator and molybdate action toward the rat glucocorticoid receptor.
Receptor 1995;5(2):117-22.
1994: Teresa Fernandes-Alnemri; Gerald Litwack; Emad S Alnemri
CPP32, a novel human apoptotic protein with homology to Caenorhabditis elegans cell death protein Ced-3 and mammalian interleukin-1 beta-converting enzyme.
The Journal of biological chemistry 1994;269(49):30761-4.
1994: Emad S Alnemri; Teresa Fernandes-Alnemri; K Pomerenke; Noreen M Robertson; K Dudley; G C DuBois; Gerald Litwack
FKBP46, a novel Sf9 insect cell nuclear immunophilin that forms a protein-kinase complex.
The Journal of biological chemistry 1994;269(49):30828-34.
1993: Noreen M Robertson; G Schulman; S Karnik; Emad S Alnemri; Gerald Litwack
Demonstration of nuclear translocation of the mineralocorticoid receptor (MR) using an anti-MR antibody and confocal laser scanning microscopy.
Molecular endocrinology (Baltimore, Md.) 1993;7(9):1226-39.
1993: Emad S Alnemri; Teresa Fernandes-Alnemri; D S Nelki; K Dudley; G C DuBois; Gerald Litwack
Overexpression, characterization, and purification of a recombinant mouse immunophilin FKBP-52 and identification of an associated phosphoprotein.
Proceedings of the National Academy of Sciences of the United States of America 1993;90(14):6839-43.
1993: Emad S Alnemri; Gerald Litwack
The steroid binding domain influences intracellular solubility of the baculovirus overexpressed glucocorticoid and mineralocorticoid receptors.
Biochemistry 1993;32(20):5387-93.
1992: Emad S Alnemri; Noreen M Robertson; T F Fernandes; Carlo M Croce; Gerald Litwack
Overexpressed full-length human BCL2 extends the survival of baculovirus-infected Sf9 insect cells.
Proceedings of the National Academy of Sciences of the United States of America 1992;89(16):7295-9.
1992: Emad S Alnemri; T F Fernandes; S Haldar; Carlo M Croce; Gerald Litwack
Involvement of BCL-2 in glucocorticoid-induced apoptosis of human pre-B-leukemias.
Cancer research 1992;52(2):491-5.
1992: G Schulman; V Daniel; M Cooper; Emad S Alnemri; A B Maksymowych; Gerald Litwack
Characterization of in vitro translated human mineralocorticoid receptor. Structure and activation.
Receptor 1992;2(3):181-94.
1991: Emad S Alnemri; A B Maksymowych; Noreen M Robertson; Gerald Litwack
Overexpression and characterization of the human mineralocorticoid receptor.
The Journal of biological chemistry 1991;266(27):18072-81.
1991: Emad S Alnemri; A B Maksymowych; Noreen M Robertson; Gerald Litwack
Characterization and purification of a functional rat glucocorticoid receptor overexpressed in a baculovirus system.
The Journal of biological chemistry 1991;266(6):3925-36.
1991: V Daniel; A B Maksymowych; Emad S Alnemri; Gerald Litwack
Cell-free synthesis of rat glucocorticoid receptor in rabbit reticulocyte lysate. In vitro synthesis of receptor in Mr 90,000 heat shock protein-depleted lysate.
The Journal of biological chemistry 1991;266(2):1320-5.
1990: Emad S Alnemri; Gerald Litwack
Activation of internucleosomal DNA cleavage in human CEM lymphocytes by glucocorticoid and novobiocin. Evidence for a non-Ca2(+)-requiring mechanism(s).
The Journal of biological chemistry 1990;265(28):17323-33.
1989: Emad S Alnemri; Gerald Litwack
Glucocorticoid-induced lymphocytolysis is not mediated by an induced endonuclease.
The Journal of biological chemistry 1989;264(7):4104-11.