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Tom Curran

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Yu Wang; Ke Xu; Jin Woo Yoo; Jessica M Y Ng; Vatsal Oza; Lee L Rubin; Anthony C Arvanites; Joel Blanchard; Tom Curran; Lance Davidow; Kelvin Lam; Andrew P McMahon
Glucocorticoid compounds modify smoothened localization and hedgehog pathway activity.
Jessica M Y Ng; Tom Curran
The Hedgehog's tale: developing strategies for targeting cancer.
Jillian L Brechbiel; Jessica M Y Ng; Tom Curran
PTHrP treatment fails to rescue bone defects caused by Hedgehog pathway inhibition in young mice.

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2012: Yu Wang; Ke Xu; Jin Woo Yoo; Jessica M Y Ng; Vatsal Oza; Lee L Rubin; Anthony C Arvanites; Joel Blanchard; Tom Curran; Lance Davidow; Kelvin Lam; Andrew P McMahon
Glucocorticoid compounds modify smoothened localization and hedgehog pathway activity.
Chemistry & biology 2012;19(8):972-82.
2011: Jessica M Y Ng; Tom Curran
The Hedgehog's tale: developing strategies for targeting cancer.
Nature reviews. Cancer 2011;11(7):493-501.
2011: Jillian L Brechbiel; Jessica M Y Ng; Tom Curran
PTHrP treatment fails to rescue bone defects caused by Hedgehog pathway inhibition in young mice.
Toxicologic pathology 2011;39(3):478-85.
2009: Yee Ping Yip; Nisha Mehta; Susan M Magdaleno; Tom Curran; Joseph W Yip
Ectopic expression of reelin alters migration of sympathetic preganglionic neurons in the spinal cord.
The Journal of comparative neurology 2009;515(2):260-8.
2008: Tom Curran; Jessica M Y Ng
Cancer: Hedgehog's other great trick.
Nature 2008;455(7211):293-4.
2008: Hiromichi Kimura; Jessica M Y Ng; Tom Curran
Transient inhibition of the Hedgehog pathway in young mice causes permanent defects in bone structure.
Cancer cell 2008;13(3):249-60.
2007: youngsoo Lee; R Kawagoe; Ken Sasai; Y Li; Helen R Russell; Tom Curran; Peter J McKinnon
Loss of suppressor-of-fused function promotes tumorigenesis.
Oncogene 2007;26(44):6442-7.
2007: Ken Sasai; Justyna T Romer; Hiromichi Kimura; Derek E Eberhart; Dennis S Rice; Tom Curran
Medulloblastomas derived from Cxcr6 mutant mice respond to treatment with a smoothened inhibitor.
Cancer research 2007;67(8):3871-7.
2006: Craig L Brumwell; Tom Curran
Developmental mouse brain gene expression maps.
The Journal of physiology 2006;575(Pt 2):343-6.
2006: Tae-Ju Park; Kelli Boyd; Tom Curran
Cardiovascular and craniofacial defects in Crk-null mice.
Molecular and cellular biology 2006;26(16):6272-82.
2006: youngsoo Lee; Heather L Miller; Helen R Russell; Kelli Boyd; Tom Curran; Peter J McKinnon
Patched2 modulates tumorigenesis in patched1 heterozygous mice.
Cancer research 2006;66(14):6964-71.
2006: Jiewu Liu; Jinhua Wang; Qian Huang; Jason Higdon; Susan M Magdaleno; Tom Curran; Jian Zuo
Gene expression profiles of mouse retinas during the second and third postnatal weeks.
Brain research 2006;1098(1):113-25.
2006: Margaret C Thompson; Christine Fuller; Twala L Hogg; James Dalton; David Finkelstein; Ching C Lau; Murali Chintagumpala; Adekunle M Adesina; David M Ashley; Stewart J Kellie; Michael D Taylor; Tom Curran; Amar Gajjar; Richard J Gilbertson
Genomics identifies medulloblastoma subgroups that are enriched for specific genetic alterations.
Journal of clinical oncology : official journal of the American Society of Clinical Oncology 2006;24(12):1924-31.
2006: Ken Sasai; Justyna T Romer; youngsoo Lee; David Finkelstein; Christine Fuller; Peter J McKinnon; Tom Curran
Shh pathway activity is down-regulated in cultured medulloblastoma cells: implications for preclinical studies.
Cancer research 2006;66(8):4215-22.
2006: Susan M Magdaleno; Patricia Jensen; Craig L Brumwell; Anna Seal; Karen Lehman; Andrew Asbury; Tony Cheung; Tommie Cornelius; Diana M Batten; Christopher Eden; Shannon M Norland; Dennis S Rice; Nilesh Dosooye; Sundeep Shakya; Perdeep Mehta; Tom Curran
BGEM: an in situ hybridization database of gene expression in the embryonic and adult mouse nervous system.
PLoS biology 2006;4(4):e86.
2006: Tammy Dellovade; Justyna T Romer; Tom Curran; Lee L Rubin
The hedgehog pathway and neurological disorders.
Annual review of neuroscience 2006;29():539-63.
2005: Tamar Uziel; Frederique Zindy; Suqing Xie; youngsoo Lee; Antoine Forget; Susan M Magdaleno; Jerold E Rehg; Christopher Calabrese; David J Solecki; Charles G Eberhart; Sarah E Sherr; Sarah Plimmer; Steven C Clifford; Mary E Hatten; Peter J McKinnon; Richard J Gilbertson; Tom Curran; Charles J Sherr; Martine F Roussel
The tumor suppressors Ink4c and p53 collaborate independently with Patched to suppress medulloblastoma formation.
Genes & development 2005;19(22):2656-67.
2005: Michael D Taylor; Helen M Poppleton; Christine Fuller; Xiaoping Su; Yongxing Liu; Patricia Jensen; Susan M Magdaleno; James Dalton; Christopher Calabrese; Julian Board; Tobey Macdonald; Jim Rutka; Abhijit Guha; Amar Gajjar; Tom Curran; Richard J Gilbertson
Radial glia cells are candidate stem cells of ependymoma.
Cancer cell 2005;8(4):323-35.
2005: Justyna T Romer; Tom Curran
Targeting medulloblastoma: small-molecule inhibitors of the Sonic Hedgehog pathway as potential cancer therapeutics.
Cancer research 2005;65(12):4975-8.
2005: Hiromichi Kimura; Daniel Stephen; Alexandra L Joyner; Tom Curran
Gli1 is important for medulloblastoma formation in Ptc1+/- mice.
Oncogene 2005;24(25):4026-36.
2004: Patricia Jensen; Susan M Magdaleno; Karen M Lehman; Dennis S Rice; Edward R LaVallie; Lisa A Collins-Racie; John McCoy; Tom Curran
A neurogenomics approach to gene expression analysis in the developing brain.
Brain research. Molecular brain research 2004;132(2):116-27.
2004: Justyna T Romer; Hiromichi Kimura; Susan M Magdaleno; Ken Sasai; Christine Fuller; Helen Baines; Michele Connelly; Clinton F Stewart; Stephen Gould; Lee L Rubin; Tom Curran
Suppression of the Shh pathway using a small molecule inhibitor eliminates medulloblastoma in Ptc1(+/-)p53(-/-) mice.
Cancer cell 2004;6(3):229-40.
2004: Justyna T Romer; Tom Curran
Medulloblastoma and retinoblastoma: oncology recapitulates ontogeny.
Cell cycle (Georgetown, Tex.) 2004;3(7):917-9.
2004: Yongcheng Huang; Susan M Magdaleno; Rachel Hopkins; Clive Slaughter; Tom Curran; Lakhu Keshvara
Tyrosine phosphorylated Disabled 1 recruits Crk family adapter proteins.
Biochemical and biophysical research communications 2004;318(1):204-12.
2004: Jared M Ordway; Katy Williams; Tom Curran
Transcription repression in oncogenic transformation: common targets of epigenetic repression in cells transformed by Fos, Ras or Dnmt1.
Oncogene 2004;23(21):3737-48.
2004: Yee Ping Yip; Christine Capriotti; Susan M Magdaleno; David Benhayon; Tom Curran; Kazunori Nakajima; Joseph W Yip
Components of the reelin signaling pathway are expressed in the spinal cord.
The Journal of comparative neurology 2004;470(2):210-9.
2003: Mikyung Yun; Lakhu Keshvara; Cheon-Gil Park; Yong-Mei Zhang; J Bradley Dickerson; Jie Zheng; Charles O Rock; Tom Curran; Hee-Won Park
Crystal structures of the Dab homology domains of mouse disabled 1 and 2.
The Journal of biological chemistry 2003;278(38):36572-81.
2003: youngsoo Lee; Heather L Miller; Patricia Jensen; Roberto Hernan; Michele Connelly; Cynthia Wetmore; Frederique Zindy; Martine F Roussel; Tom Curran; Richard J Gilbertson; Peter J McKinnon
A molecular fingerprint for medulloblastoma.
Cancer research 2003;63(17):5428-37.
2003: Olav M Andersen; David Benhayon; Tom Curran; Thomas E Willnow
Differential binding of ligands to the apolipoprotein E receptor 2.
Biochemistry 2003;42(31):9355-64.
2003: Ramin Homayouni; Susan M Magdaleno; Lakhu Keshvara; Dennis S Rice; Tom Curran
Interaction of Disabled-1 and the GTPase activating protein Dab2IP in mouse brain.
Brain research. Molecular brain research 2003;115(2):121-9.
2003: Tom Curran
From bings to biology: taking a different path in cancer research.
Cancer biology & therapy 2003;2(4):456-9.
2003: Leyi Li; Michele C Connelly; Cynthia Wetmore; Tom Curran; James I Morgan
Mouse embryos cloned from brain tumors.
Cancer research 2003;63(11):2733-6.
2003: Jared M Ordway; Derek E Eberhart; Tom Curran
Cysteine 64 of Ref-1 is not essential for redox regulation of AP-1 DNA binding.
Molecular and cellular biology 2003;23(12):4257-66.
2003: David Benhayon; Susan M Magdaleno; Tom Curran
Binding of purified Reelin to ApoER2 and VLDLR mediates tyrosine phosphorylation of Disabled-1.
Brain research. Molecular brain research 2003;112(1-2):33-45.
2002: Susan M Magdaleno; Grace M Northcutt; Tom Curran; Cornelia Kurschner
mPPP1R16B is a novel mouse protein phosphatase 1 targeting subunit whose mRNA is located in cell bodies and dendrites of neurons in four distinct regions of the brain.
Brain research. Gene expression patterns 2002;1(3-4):143-9.
2002: Richard J Gilbertson; Lyndsay Bentley; Roberto Hernan; Teemu T Junttila; Adrian J Frank; Hannu Haapasalo; Michele Connelly; Cynthia Wetmore; Tom Curran; Klaus Elenius; David W Ellison
ERBB receptor signaling promotes ependymoma cell proliferation and represents a potential novel therapeutic target for this disease.
Clinical cancer research : an official journal of the American Association for Cancer Research 2002;8(10):3054-64.
2002: Lakhu Keshvara; Susan M Magdaleno; David Benhayon; Tom Curran
Cyclin-dependent kinase 5 phosphorylates disabled 1 independently of Reelin signaling.
The Journal of neuroscience : the official journal of the Society for Neuroscience 2002;22(12):4869-77.
2002: Jared M Ordway; Tom Curran
Methylation matters: modeling a manageable genome.
Cell growth & differentiation : the molecular biology journal of the American Association for Cancer Research 2002;13(4):149-62.
2002: Susan M Magdaleno; Lakhu Keshvara; Tom Curran
Rescue of ataxia and preplate splitting by ectopic expression of Reelin in reeler mice.
Neuron 2002;33(4):573-86.
2001: Susan M Magdaleno; Tom Curran
Brain development: integrins and the Reelin pathway.
Current biology : CB 2001;11(24):R1032-5.
2001: Ramin Homayouni; Dennis S Rice; Tom Curran
Disabled-1 interacts with a novel developmentally regulated protocadherin.
Biochemical and biophysical research communications 2001;289(2):539-47.
2001: Dennis S Rice; Steven Nusinowitz; A M Azimi; A Martínez; E Soriano; Tom Curran
The reelin pathway modulates the structure and function of retinal synaptic circuitry.
Neuron 2001;31(6):929-41.
2001: Lakhu Keshvara; David Benhayon; Susan M Magdaleno; Tom Curran
Identification of reelin-induced sites of tyrosyl phosphorylation on disabled 1.
The Journal of biological chemistry 2001;276(19):16008-14.
2001: Cynthia Wetmore; Derek E Eberhart; Tom Curran
Loss of p53 but not ARF accelerates medulloblastoma in mice heterozygous for patched.
Cancer research 2001;61(2):513-6.
2001: Dennis S Rice; Tom Curran
Role of the reelin signaling pathway in central nervous system development.
Annual review of neuroscience 2001;24():1005-39.
2000: Dennis S Rice; Tom Curran
Disabled-1 is expressed in type AII amacrine cells in the mouse retina.
The Journal of comparative neurology 2000;424(2):327-38.
2000: Ramin Homayouni; Tom Curran
Cortical development: Cdk5 gets into sticky situations.
Current biology : CB 2000;10(9):R331-4.
2000: Cynthia Wetmore; Derek E Eberhart; Tom Curran
The normal patched allele is expressed in medulloblastomas from mice with heterozygous germ-line mutation of patched.
Cancer research 2000;60(8):2239-46.
1999: Dennis S Rice; Tom Curran
Mutant mice with scrambled brains: understanding the signaling pathways that control cell positioning in the CNS.
Genes & development 1999;13(21):2758-73.
1999: Gabriella D'Arcangelo; Ramin Homayouni; Lakhu Keshvara; Dennis S Rice; Michael Sheldon; Tom Curran
Reelin is a ligand for lipoprotein receptors.
Neuron 1999;24(2):471-9.
1999: Ramin Homayouni; Dennis S Rice; Michael Sheldon; Tom Curran
Disabled-1 binds to the cytoplasmic domain of amyloid precursor-like protein 1.
The Journal of neuroscience : the official journal of the Society for Neuroscience 1999;19(17):7507-15.
1999: M Alvarez-Dolado; M Ruiz; José A del Río; Soledad Alcántara; Ferran Burgaya; Michael Sheldon; K Nakajima; Juan Bernal; Brian Howell; Tom Curran; Eduardo Soriano; Alberto Muñoz
Thyroid hormone regulates reelin and dab1 expression during brain development.
The Journal of neuroscience : the official journal of the Society for Neuroscience 1999;19(16):6979-93.
1999: Victor Borrell; José A del Río; Soledad Alcántara; M Derer; Albert Martínez; G D'Arcangelo; K Nakajima; K Mikoshiba; P Derer; Tom Curran; Eduardo Soriano
Reelin regulates the development and synaptogenesis of the layer-specific entorhino-hippocampal connections.
The Journal of neuroscience : the official journal of the Society for Neuroscience 1999;19(4):1345-58.
1999: A V Bakin; Tom Curran
Role of DNA 5-methylcytosine transferase in cell transformation by fos.
Science (New York, N.Y.) 1999;283(5400):387-90.
1998: M Vendrell; Tom Curran; James I Morgan
A gene expression approach to mapping the functional maturation of the hippocampus.
Brain research. Molecular brain research 1998;63(1):25-34.
1998: Soledad Alcántara; M Ruiz; G D'Arcangelo; Frédéric Ezan; Luis de Lecea; Tom Curran; Constantino Sotelo; Eduardo Soriano
Regional and cellular patterns of reelin mRNA expression in the forebrain of the developing and adult mouse.
The Journal of neuroscience : the official journal of the Society for Neuroscience 1998;18(19):7779-99.
1998: Dennis S Rice; Michael Sheldon; Gabriella D'Arcangelo; K Nakajima; Dan Goldowitz; Tom Curran
Disabled-1 acts downstream of Reelin in a signaling pathway that controls laminar organization in the mammalian brain.
Development (Cambridge, England) 1998;125(18):3719-29.
1998: Gabriella D'Arcangelo; Tom Curran
Reeler: new tales on an old mutant mouse.
BioEssays : news and reviews in molecular, cellular and developmental biology 1998;20(3):235-44.
1997: Dan Goldowitz; R C Cushing; Eric D Laywell; Gabriella D'Arcangelo; Michael Sheldon; Hope O Sweet; Muriel T Davisson; Dennis A Steindler; Tom Curran
Cerebellar disorganization characteristic of reeler in scrambler mutant mice despite presence of reelin.
The Journal of neuroscience : the official journal of the Society for Neuroscience 1997;17(22):8767-77.
1997: Michael Sheldon; Dennis S Rice; Gabriella D'Arcangelo; H Yoneshima; K Nakajima; Katsuhiko Mikoshiba; Brian Howell; J A Cooper; Dan Goldowitz; Tom Curran
Scrambler and yotari disrupt the disabled gene and produce a reeler-like phenotype in mice.
Nature 1997;389(6652):730-3.
1997: U DeSilva; Gabriella D'Arcangelo; V V Braden; J Chen; G G Miao; Tom Curran; Eric Green
The human reelin gene: isolation, sequencing, and mapping on chromosome 7.
Genome research 1997;7(2):157-64.
1997: Gabriella D'Arcangelo; K Nakajima; T Miyata; M Ogawa; K Mikoshiba; Tom Curran
Reelin is a secreted glycoprotein recognized by the CR-50 monoclonal antibody.
The Journal of neuroscience : the official journal of the Society for Neuroscience 1997;17(1):23-31.
1996: M Yuzaki; D Forrest; Tom Curran; J A Connor
Selective activation of calcium permeability by aspartate in Purkinje cells.
Science (New York, N.Y.) 1996;273(5278):1112-4.
1996: M Yuzaki; D Forrest; L M Verselis; S C Sun; Tom Curran; J A Connor
Functional NMDA receptors are transiently active and support the survival of Purkinje cells in culture.
The Journal of neuroscience : the official journal of the Society for Neuroscience 1996;16(15):4651-61.
1996: Gabriella D'Arcangelo; G G Miao; Tom Curran
Detection of the reelin breakpoint in reeler mice.
Brain research. Molecular brain research 1996;39(1-2):234-6.
1996: Douglas Forrest; L C Erway; L Ng; Richard A Altschuler; Tom Curran
Thyroid hormone receptor beta is essential for development of auditory function.
Nature genetics 1996;13(3):354-7.
1996: G M Kasof; R J Smeyne; Tom Curran; James I Morgan
Developmental expression of Fos-lacZ in the brains of postnatal transgenic rats.
Brain research. Developmental brain research 1996;93(1-2):191-7.
1996: M L Martin; Paul M Lieberman; Tom Curran
Fos-Jun dimerization promotes interaction of the basic region with TFIIE-34 and TFIIF.
Molecular and cellular biology 1996;16(5):2110-8.
1996: Douglas Forrest; G Golarai; J Connor; Tom Curran
Genetic analysis of thyroid hormone receptors in development and disease.
Recent progress in hormone research 1996;51():1-22.
1995: G M Kasof; N K Mahanty; Lucas Pozzo-Miller; Tom Curran; John A Connor; James I Morgan
Spontaneous and evoked glutamate signalling influences Fos-lacZ expression and pyramidal cell death in hippocampal slice cultures from transgenic rats.
Brain research. Molecular brain research 1995;34(2):197-208.
1995: V E Isaac; L Patel; Tom Curran; C Abate-Shen
Use of fluorescence resonance energy transfer to estimate intramolecular distances in the Msx-1 homeodomain.
Biochemistry 1995;34(46):15276-81.
1995: L Ng; Douglas Forrest; Bryan R Haugen; William M Wood; Tom Curran
N-terminal variants of thyroid hormone receptor beta: differential function and potential contribution to syndrome of resistance to thyroid hormone.
Molecular endocrinology (Baltimore, Md.) 1995;9(9):1202-13.
1995: G M Kasof; A Mandelzys; S D Maika; R E Hammer; Tom Curran; James I Morgan
Kainic acid-induced neuronal death is associated with DNA damage and a unique immediate-early gene response in c-fos-lacZ transgenic rats.
The Journal of neuroscience : the official journal of the Society for Neuroscience 1995;15(6):4238-49.
1995: Gabriella D'Arcangelo; G G Miao; S C Chen; H D Soares; J I Morgan; Tom Curran
A protein related to extracellular matrix proteins deleted in the mouse mutant reeler.
Nature 1995;374(6524):719-23.
1995: Tom Curran; James I Morgan
Fos: an immediate-early transcription factor in neurons.
Journal of neurobiology 1995;26(3):403-12.
1995: L M Robertson; Tom K Kerppola; M Vendrell; D Luk; Richard J Smeyne; C Bocchiaro; J I Morgan; Tom Curran
Regulation of c-fos expression in transgenic mice requires multiple interdependent transcription control elements.
Neuron 1995;14(2):241-52.
1995: James I Morgan; Tom Curran
Immediate-early genes: ten years on.
Trends in neurosciences 1995;18(2):66-7.
1995: S C Chen; Tom Curran; James I Morgan
Apoptosis in the nervous system: new revelations.
Journal of clinical pathology 1995;48(1):7-12.
1994: H D Soares; Tom Curran; James I Morgan
Transcription factors as molecular mediators in cell death.
Annals of the New York Academy of Sciences 1994;747():172-82.
1994: G G Miao; Richard J Smeyne; Gabriella D'Arcangelo; N G Copeland; N A Jenkins; J I Morgan; Tom Curran
Isolation of an allele of reeler by insertional mutagenesis.
Proceedings of the National Academy of Sciences of the United States of America 1994;91(23):11050-4.
1994: Tom K Kerppola; Tom Curran
A conserved region adjacent to the basic domain is required for recognition of an extended DNA binding site by Maf/Nrl family proteins.
Oncogene 1994;9(11):3149-58.
1994: Z Shang; V E Isaac; H Li; L Patel; K M Catron; Tom Curran; Gaetano T Montelione; C Abate
Design of a "minimAl" homeodomain: the N-terminal arm modulates DNA binding affinity and stabilizes homeodomain structure.
Proceedings of the National Academy of Sciences of the United States of America 1994;91(18):8373-7.
1994: Douglas Forrest; M Yuzaki; H D Soares; L Ng; D C Luk; Morgan Sheng; C L Stewart; J I Morgan; J A Connor; Tom Curran
Targeted disruption of NMDA receptor 1 gene abolishes NMDA response and results in neonatal death.
Neuron 1994;13(2):325-38.
1994: L R Patel; Tom Curran; Tom K Kerppola
Energy transfer analysis of Fos-Jun dimerization and DNA binding.
Proceedings of the National Academy of Sciences of the United States of America 1994;91(15):7360-4.
1994: G G Miao; Tom Curran
Cell transformation by c-fos requires an extended period of expression and is independent of the cell cycle.
Molecular and cellular biology 1994;14(6):4295-310.
1994: Tom K Kerppola; Tom Curran
Maf and Nrl can bind to AP-1 sites and form heterodimers with Fos and Jun.
Oncogene 1994;9(3):675-84.
1994: S Xanthoudakis; G G Miao; Tom Curran
The redox and DNA-repair activities of Ref-1 are encoded by nonoverlapping domains.
Proceedings of the National Academy of Sciences of the United States of America 1994;91(1):23-7.
1994: W Hsu; Tom K Kerppola; Phang-Lang Chen; Tom Curran; S Chen-Kiang
Fos and Jun repress transcription activation by NF-IL6 through association at the basic zipper region.
Molecular and cellular biology 1994;14(1):268-76.
1994: S Xanthoudakis; Tom Curran
Analysis of c-Fos and c-Jun redox-dependent DNA binding activity.
Methods in enzymology 1994;234():163-74.
1993: L Ng; Douglas Forrest; Tom Curran
Differential roles for Fos and Jun in DNA-binding: redox-dependent and independent functions.
Nucleic acids research 1993;21(25):5831-7.
1993: Tom K Kerppola; Tom Curran
Selective DNA bending by a variety of bZIP proteins.
Molecular and cellular biology 1993;13(9):5479-89.
1993: C Abate; S J Baker; Susan Lees-Miller; C W Anderson; D R Marshak; Tom Curran
Dimerization and DNA binding alter phosphorylation of Fos and Jun.
Proceedings of the National Academy of Sciences of the United States of America 1993;90(14):6766-70.
1993: Tom K Kerppola; D Luk; Tom Curran
Fos is a preferential target of glucocorticoid receptor inhibition of AP-1 activity in vitro.
Molecular and cellular biology 1993;13(6):3782-91.
1993: R Molinar-Rode; R J Smeyne; Tom Curran; James I Morgan
Regulation of proto-oncogene expression in adult and developing lungs.
Molecular and cellular biology 1993;13(6):3213-20.
1993: M Vendrell; Tom Curran; James I Morgan
Glutamate, immediate-early genes, and cell death in the nervous system.
Annals of the New York Academy of Sciences 1993;679():132-41.
1993: Richard J Smeyne; M Vendrell; Michael Hayward; S J Baker; G G Miao; Karl Schilling; L M Robertson; Tom Curran; J I Morgan
Continuous c-fos expression precedes programmed cell death in vivo.
Nature 1993;363(6425):166-9.
1993: Richard J Smeyne; Karl Schilling; John Oberdick; L Robertson; D Luk; Tom Curran; J I Morgan
A fos-lac Z transgenic mouse that can be used for neuroanatomic mapping.
Advances in neurology 1993;59():285-91.
1993: Tom Curran; C Abate; S Baker; Tom K Kerppola; S Xanthoudakis
The regulation of c-fos: too much is never enough.
Advances in second messenger and phosphoprotein research 1993;28():271-7.
1992: Richard J Smeyne; Tom Curran; J I Morgan
Temporal and spatial expression of a fos-lacZ transgene in the developing nervous system.
Brain research. Molecular brain research 1992;16(1-2):158-62.
1992: S J Baker; Tom K Kerppola; D Luk; M T Vandenberg; D R Marshak; Tom Curran; C Abate
Jun is phosphorylated by several protein kinases at the same sites that are modified in serum-stimulated fibroblasts.
Molecular and cellular biology 1992;12(10):4694-705.
1992: S Xanthoudakis; G Miao; F Wang; Y C Pan; Tom Curran
Redox activation of Fos-Jun DNA binding activity is mediated by a DNA repair enzyme.
The EMBO journal 1992;11(9):3323-35.
1992: S Xanthoudakis; Tom Curran
Identification and characterization of Ref-1, a nuclear protein that facilitates AP-1 DNA-binding activity.
The EMBO journal 1992;11(2):653-65.
1992: Richard J Smeyne; Karl Schilling; L Robertson; D Luk; John Oberdick; Tom Curran; J I Morgan
fos-lacZ transgenic mice: mapping sites of gene induction in the central nervous system.
Neuron 1992;8(1):13-23.
1991: C Abate; D R Marshak; Tom Curran
Fos is phosphorylated by p34cdc2, cAMP-dependent protein kinase and protein kinase C at multiple sites clustered within regulatory regions.
Oncogene 1991;6(12):2179-85.
1991: Tom K Kerppola; Tom Curran
DNA bending by Fos and Jun: the flexible hinge model.
Science (New York, N.Y.) 1991;254(5035):1210-4.
1991: J I Morgan; Tom Curran
Proto-oncogene transcription factors and epilepsy.
Trends in pharmacological sciences 1991;12(9):343-9.
1991: Tom K Kerppola; Tom Curran
Fos-Jun heterodimers and Jun homodimers bend DNA in opposite orientations: implications for transcription factor cooperativity.
Cell 1991;66(2):317-26.
1991: C Abate; D Luk; Tom Curran
Transcriptional regulation by Fos and Jun in vitro: interaction among multiple activator and regulatory domains.
Molecular and cellular biology 1991;11(7):3624-32.
1991: Karl Schilling; D Luk; J I Morgan; Tom Curran
Regulation of a fos-lacZ fusion gene: a paradigm for quantitative analysis of stimulus-transcription coupling.
Proceedings of the National Academy of Sciences of the United States of America 1991;88(13):5665-9.
1991: K Schilling; Tom Curran; J I Morgan
Fosvergnügen. The excitement of immediate-early genes.
Annals of the New York Academy of Sciences 1991;627():115-23.
1991: J I Morgan; Tom Curran
Stimulus-transcription coupling in the nervous system: involvement of the inducible proto-oncogenes fos and jun.
Annual review of neuroscience 1991;14():421-51.
1990: L Patel; C Abate; Tom Curran
Altered protein conformation on DNA binding by Fos and Jun.
Nature 1990;347(6293):572-5.
1990: C Abate; D Luk; Tom Curran
A ubiquitous nuclear protein stimulates the DNA-binding activity of fos and jun indirectly.
Cell growth & differentiation : the molecular biology journal of the American Association for Cancer Research 1990;1(10):455-62.
1990: C Abate; D Luk; E Gagne; R G Roeder; Tom Curran
Fos and jun cooperate in transcriptional regulation via heterologous activation domains.
Molecular and cellular biology 1990;10(10):5532-5.
1990: C Abate; L Patel; Frank J Rauscher; Tom Curran
Redox regulation of fos and jun DNA-binding activity in vitro.
Science (New York, N.Y.) 1990;249(4973):1157-61.
1990: D Gius; X M Cao; Frank J Rauscher; D R Cohen; Tom Curran; Vikas P Sukhatme
Transcriptional activation and repression by Fos are independent functions: the C terminus represses immediate-early gene expression via CArG elements.
Molecular and cellular biology 1990;10(8):4243-55.
1990: D R Cohen; Tom Curran
Analysis of dimerization and DNA binding functions in Fos and Jun by domain-swapping: involvement of residues outside the leucine zipper/basic region.
Oncogene 1990;5(6):929-39.
1990: P F Macgregor; C Abate; Tom Curran
Direct cloning of leucine zipper proteins: Jun binds cooperatively to the CRE with CRE-BP1.
Oncogene 1990;5(4):451-8.
1990: C Abate; Tom Curran
Encounters with Fos and Jun on the road to AP-1.
Seminars in cancer biology 1990;1(1):19-26.
1990: C Abate; D Luk; R Gentz; Frank J Rauscher; Tom Curran
Expression and purification of the leucine zipper and DNA-binding domains of Fos and Jun: both Fos and Jun contact DNA directly.
Proceedings of the National Academy of Sciences of the United States of America 1990;87(3):1032-6.
1990: Tom Curran; C Abate; D R Cohen; P F Macgregor; Frank J Rauscher; J L Sonnenberg; J A Connor; J I Morgan
Inducible proto-oncogene transcription factors: third messengers in the brain?
Cold Spring Harbor symposia on quantitative biology 1990;55():225-34.
1990: J I Morgan; Tom Curran
Inducible proto-oncogenes of the nervous system: their contribution to transcription factors and neuroplasticity.
Progress in brain research 1990;86():287-94.
1989: J L Sonnenberg; Frank J Rauscher; J I Morgan; Tom Curran
Regulation of proenkephalin by Fos and Jun.
Science (New York, N.Y.) 1989;246(4937):1622-5.
1989: J L Sonnenberg; C Mitchelmore; P F Macgregor-Leon; J Hempstead; J I Morgan; Tom Curran
Glutamate receptor agonists increase the expression of Fos, Fra, and AP-1 DNA binding activity in the mammalian brain.
Journal of neuroscience research 1989;24(1):72-80.
1989: J L Sonnenberg; P F Macgregor-Leon; Tom Curran; J I Morgan
Dynamic alterations occur in the levels and composition of transcription factor AP-1 complexes after seizure.
Neuron 1989;3(3):359-65.
1989: R Gentz; Frank J Rauscher; C Abate; Tom Curran
Parallel association of Fos and Jun leucine zippers juxtaposes DNA binding domains.
Science (New York, N.Y.) 1989;243(4899):1695-9.
1989: D R Cohen; Paulo C P Ferreira; R Gentz; B R Franza; Tom Curran
The product of a fos-related gene, fra-1, binds cooperatively to the AP-1 site with Jun: transcription factor AP-1 is comprised of multiple protein complexes.
Genes & development 1989;3(2):173-84.
1989: T J Bos; Frank J Rauscher; Tom Curran; Peter K Vogt
The carboxy terminus of the viral Jun oncoprotein is required for complex formation with the cellular Fos protein.
Oncogene 1989;4(2):123-6.
1989: D R Cohen; Tom Curran
The structure and function of the fos proto-oncogene.
Critical reviews in oncogenesis 1989;1(1):65-88.
1989: J I Morgan; Tom Curran
Calcium and proto-oncogene involvement in the immediate-early response in the nervous system.
Annals of the New York Academy of Sciences 1989;568():283-90.
1988: Frank J Rauscher; Pamela Voulalas; B R Franza; Tom Curran
Fos and Jun bind cooperatively to the AP-1 site: reconstitution in vitro.
Genes & development 1988;2(12B):1687-99.
1988: Tom Curran; B R Franza
Fos and Jun: the AP-1 connection.
Cell 1988;55(3):395-7.
1988: Frank J Rauscher; D R Cohen; Tom Curran; T J Bos; Peter K Vogt; D Bohmann; Robert Tjian; B R Franza
Fos-associated protein p39 is the product of the jun proto-oncogene.
Science (New York, N.Y.) 1988;240(4855):1010-6.
1988: D R Cohen; Tom Curran
fra-1: a serum-inducible, cellular immediate-early gene that encodes a fos-related antigen.
Molecular and cellular biology 1988;8(5):2063-9.
1988: Vikas P Sukhatme; X M Cao; L C Chang; C H Tsai-Morris; D Stamenkovich; Paulo C P Ferreira; D R Cohen; S A Edwards; TB Shows; Tom Curran
A zinc finger-encoding gene coregulated with c-fos during growth and differentiation, and after cellular depolarization.
Cell 1988;53(1):37-43.
1988: Frank J Rauscher; L C Sambucetti; Tom Curran; Robert Distel; Bruce M Spiegelman
Common DNA binding site for Fos protein complexes and transcription factor AP-1.
Cell 1988;52(3):471-80.
1988: Tom Curran; Frank J Rauscher; D R Cohen; B R Franza
Beyond the second messenger: oncogenes and transcription factors.
Cold Spring Harbor symposia on quantitative biology 1988;53 Pt 2():769-77.
1987: B R Franza; L C Sambucetti; D R Cohen; Tom Curran
Analysis of Fos protein complexes and Fos-related antigens by high-resolution two-dimensional gel electrophoresis.
Oncogene 1987;1(2):213-21.
1987: Tom Curran; M B Gordon; K L Rubino; L C Sambucetti
Isolation and characterization of the c-fos(rat) cDNA and analysis of post-translational modification in vitro.
Oncogene 1987;2(1):79-84.
1985: Tom Curran; R Bravo; R Müller
Transient induction of c-fos and c-myc in an immediate consequence of growth factor stimulation.
Cancer surveys 1985;4(4):655-81.