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Ronen Alon

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Ronen Alon; Sussan Nourshargh
Learning in motion: pericytes instruct migrating innate leukocytes.
Raizy Gruda; Chamutal Gur; Saar Mizrahi; Hagit Achdout; Memet Aker; Ronen Alon; Yotam Bar-On; Alice C N Brown; Daniel M Davis; Sara W Feigelson; Valentin Grabovsky; Ofer Mandelboim
Loss of kindlin-3 alters the threshold for NK cell activation in human leukocyte adhesion deficiency-III.
Ronen Alon; Sara W Feigelson
Chemokine-triggered leukocyte arrest: force-regulated bi-directional integrin activation in quantal adhesive contacts.

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All Publications

2013: Ronen Alon; Sussan Nourshargh
Learning in motion: pericytes instruct migrating innate leukocytes.
Nature immunology 2013;14(1):14-5.
2012: Raizy Gruda; Chamutal Gur; Saar Mizrahi; Hagit Achdout; Memet Aker; Ronen Alon; Yotam Bar-On; Alice C N Brown; Daniel M Davis; Sara W Feigelson; Valentin Grabovsky; Ofer Mandelboim
Loss of kindlin-3 alters the threshold for NK cell activation in human leukocyte adhesion deficiency-III.
Blood 2012;120(19):3915-24.
2012: Ronen Alon; Sara W Feigelson
Chemokine-triggered leukocyte arrest: force-regulated bi-directional integrin activation in quantal adhesive contacts.
Current opinion in cell biology 2012;24(5):670-6.
2012: Sigal Nakav; David Shoseyov; Shani Bialik; Shmuel Cohen; Sara W Feigelson; Adi Kimchi; Ronen Alon
Tumor suppressor death-associated protein kinase attenuates inflammatory responses in the lung.
American journal of respiratory cell and molecular biology 2012;46(3):313-22.
2012: Ziv Shulman; Ronen Alon
Real-time analysis of integrin-dependent transendothelial migration and integrin-independent interstitial motility of leukocytes.
Methods in molecular biology (Clifton, N.J.) 2012;757():31-45.
2011: Sara W Feigelson; Valentin Grabovsky; Eugenia Klein; Eugenia Manevich-Mendelson; Ronit Pasvolsky; Vera Shinder; Ziv Shulman; Memet Aker; Amos Etzioni; Ronen Alon
Kindlin-3 is required for the stabilization of TCR-stimulated LFA-1:ICAM-1 bonds critical for lymphocyte arrest and spreading on dendritic cells.
Blood 2011;117(26):7042-52.
2011: Yaron Vagima; Ronen Alon; Polina Goichberg; Orit Kollet; Kfir Lapid; Tsvee Lapidot
Pathways implicated in stem cell migration: the SDF-1/CXCR4 axis.
Methods in molecular biology (Clifton, N.J.) 2011;750():277-89.
2010: Eugenia Manevich-Mendelson; Valentin Grabovsky; Sara W Feigelson; Guy Cinamon; Yael Gore; Gera Goverse; Susan J Monkley; Raanan Margalit; Doron Melamed; Reina E Mebius; David R Critchley; Idit Shachar; Ronen Alon
Talin1 is required for integrin-dependent B lymphocyte homing to lymph nodes and the bone marrow but not for follicular B-cell maturation in the spleen.
Blood 2010;116(26):5907-18.
2010: Sara W Feigelson; Ronit Pasvolsky; Saso Cemerski; Ziv Shulman; Valentin Grabovsky; Tal Ilani; Adi Sagiv; Fabrice Lemaitre; Carlo Laudanna; Andrey S Shaw; Ronen Alon
Occupancy of lymphocyte LFA-1 by surface-immobilized ICAM-1 is critical for TCR- but not for chemokine-triggered LFA-1 conversion to an open headpiece high-affinity state.
Journal of immunology (Baltimore, Md. : 1950) 2010;185(12):7394-404.
2010: Ronen Alon
Trapped versus soluble chemokines: functions in leukocyte adhesion and motility.
Immunity 2010;33(5):654-6.
2010: Ronen Alon
Chemokine arrest signals to leukocyte integrins trigger bi-directional-occupancy of individual heterodimers by extracellular and cytoplasmic ligands.
Cell adhesion & migration 2010;4(2):211-4.
2009: Eugenia Manevich-Mendelson; Sara W Feigelson; Ronit Pasvolsky; Memet Aker; Valentin Grabovsky; Ziv Shulman; Sara Sebnem Kilic; Maria Alessandra Rosenthal-Allieri; Shifra Ben-Dor; Adi Mory; Alain Bernard; Markus Moser; Amos Etzioni; Ronen Alon
Loss of Kindlin-3 in LAD-III eliminates LFA-1 but not VLA-4 adhesiveness developed under shear flow conditions.
Blood 2009;114(11):2344-53.
2009: Amnon Buxboim; Erez Geron; Ronen Alon; Roy Bar-Ziv
A biochip model of lymphocyte locomotion on confined chemokine tracks.
Small (Weinheim an der Bergstrasse, Germany) 2009;5(15):1723-6.
2009: Tali Feferman; Revital Aricha; Keren Mizrachi; Erez Geron; Ronen Alon; Miriam C Souroujon; Sara Fuchs
Suppression of experimental autoimmune myasthenia gravis by inhibiting the signaling between IFN-gamma inducible protein 10 (IP-10) and its receptor CXCR3.
Journal of neuroimmunology 2009;209(1-2):87-95.
2009: Ziv Shulman; Vera Shinder; Eugenia Klein; Valentin Grabovsky; Orna Yeger; Erez Geron; Alessio Montresor; Matteo Bolomini-Vittori; Sara W Feigelson; Tomas Kirchhausen; Carlo Laudanna; Guy Shakhar; Ronen Alon
Lymphocyte crawling and transendothelial migration require chemokine triggering of high-affinity LFA-1 integrin.
Immunity 2009;30(3):384-96.
2009: Ziv Shulman; Ronen Alon
Chapter 14. Real-time in vitro assays for studying the role of chemokines in lymphocyte transendothelial migration under physiologic flow conditions.
Methods in enzymology 2009;461():311-32.
2009: Ronen Alon; Sara W Feigelson
Chemokine signaling to lymphocyte integrins under shear flow.
Microcirculation (New York, N.Y. : 1994) 2009;16(1):3-16.
2008: Liat Flaishon; Gili Hart; Einat Zelman; Christine Moussion; Valentin Grabovsky; Guy Lapidot Tal; Sara W Feigelson; Raanan Margalit; Alon Harmelin; Tamar Avin-Wittenberg; David Shoseyov; Ronen Alon; Jean-Philippe Girard; Idit Shachar
Anti-inflammatory effects of an inflammatory chemokine: CCL2 inhibits lymphocyte homing by modulation of CCL21-triggered integrin-mediated adhesions.
Blood 2008;112(13):5016-25.
2008: Tanja Nicole Hartmann; Valentin Grabovsky; Ronit Pasvolsky; Ziv Shulman; Eike C Buss; Asaf Spiegel; Arnon Nagler; Tsvee Lapidot; Marcus Thelen; Ronen Alon
A crosstalk between intracellular CXCR7 and CXCR4 involved in rapid CXCL12-triggered integrin activation but not in chemokine-triggered motility of human T lymphocytes and CD34+ cells.
Journal of leukocyte biology 2008;84(4):1130-40.
2008: Ronen Alon; Klaus Ley
Cells on the run: shear-regulated integrin activation in leukocyte rolling and arrest on endothelial cells.
Current opinion in cell biology 2008;20(5):525-32.
2008: Adi Mory; Sara W Feigelson; Nese Yarali; Sara S Kilic; Gulsum I Bayhan; Ruth Gershoni-Baruch; Amos Etzioni; Ronen Alon
Kindlin-3: a new gene involved in the pathogenesis of LAD-III.
Blood 2008;112(6):2591.
2008: Ronit Pasvolsky; Valentin Grabovsky; Cinzia Giagulli; Ziv Shulman; Revital Shamri; Sara W Feigelson; Carlo Laudanna; Ronen Alon
RhoA is involved in LFA-1 extension triggered by CXCL12 but not in a novel outside-in LFA-1 activation facilitated by CXCL9.
Journal of immunology (Baltimore, Md. : 1950) 2008;180(5):2815-23.
2007: Eilon Woolf; Irina L Grigorova; Adi Sagiv; Valentin Grabovsky; Sara W Feigelson; Ziv Shulman; Tanja Hartmann; Michael Sixt; Jason G Cyster; Ronen Alon
Lymph node chemokines promote sustained T lymphocyte motility without triggering stable integrin adhesiveness in the absence of shear forces.
Nature immunology 2007;8(10):1076-85.
2007: Eugenia Manevich; Valentin Grabovsky; Sara W Feigelson; Ronen Alon
Talin 1 and paxillin facilitate distinct steps in rapid VLA-4-mediated adhesion strengthening to vascular cell adhesion molecule 1.
The Journal of biological chemistry 2007;282(35):25338-48.
2007: Oren Dwir; Valentin Grabovsky; Ronit Pasvolsky; Eugenia Manevich; Revital Shamri; Paul Gutwein; Sara W Feigelson; Peter Altevogt; Ronen Alon
Membranal cholesterol is not required for L-selectin adhesiveness in primary lymphocytes but controls a chemokine-induced destabilization of L-selectin rolling adhesions.
Journal of immunology (Baltimore, Md. : 1950) 2007;179(2):1030-8.
2007: Ronit Pasvolsky; Sara W Feigelson; Sara Sebnem Kilic; Amos J Simon; Guy Tal-Lapidot; Valentin Grabovsky; Jill R Crittenden; Ninette Amariglio; Michal Safran; Ann M Graybiel; Gideon Rechavi; Shifra Ben-Dor; Amos Etzioni; Ronen Alon
A LAD-III syndrome is associated with defective expression of the Rap-1 activator CalDAG-GEFI in lymphocytes, neutrophils, and platelets.
The Journal of experimental medicine 2007;204(7):1571-82.
2007: Taylor Schreiber; Vera Shinder; Derek W Cain; Ronen Alon; Robert Sackstein
Shear flow-dependent integration of apical and subendothelial chemokines in T-cell transmigration: implications for locomotion and the multistep paradigm.
Blood 2007;109(4):1381-6.
2007: Ronen Alon; Michael L Dustin
Force as a facilitator of integrin conformational changes during leukocyte arrest on blood vessels and antigen-presenting cells.
Immunity 2007;26(1):17-27.
2006: Ziv Shulman; Ronit Pasvolsky; Eilon Woolf; Valentin Grabovsky; Sara W Feigelson; Neta Erez; Yoshinori Fukui; Ronen Alon
DOCK2 regulates chemokine-triggered lateral lymphocyte motility but not transendothelial migration.
Blood 2006;108(7):2150-8.
2006: Michal Dagan-Berger; Rotem Feniger-Barish; Shani Avniel; Hanna Wald; Eithan Galun; Valentin Grabovsky; Ronen Alon; Arnon Nagler; Adit Ben-Baruch; Amnon Peled
Role of CXCR3 carboxyl terminus and third intracellular loop in receptor-mediated migration, adhesion and internalization in response to CXCL11.
Blood 2006;107(10):3821-31.
2005: Ronen Alon; Sara W Feigelson; Eugenia Manevich; David M Rose; Julia Schmitz; Darryl R Overby; Eitan Winter; Valentin Grabovsky; Vera Shinder; Benjamin D Matthews; Maya Sokolovsky-Eisenberg; Donald Ingber; Martin Benoit; Mark H Ginsberg
Alpha4beta1-dependent adhesion strengthening under mechanical strain is regulated by paxillin association with the alpha4-cytoplasmic domain.
The Journal of cell biology 2005;171(6):1073-84.
2005: Andrew D Luster; Ronen Alon; Ulrich H von Andrian
Immune cell migration in inflammation: present and future therapeutic targets.
Nature immunology 2005;6(12):1182-90.
2005: Lin Yang; Richard M Froio; Tracey E Sciuto; Ann M Dvorak; Ronen Alon; Francis W Luscinskas
ICAM-1 regulates neutrophil adhesion and transcellular migration of TNF-alpha-activated vascular endothelium under flow.
Blood 2005;106(2):584-92.
2005: Revital Shamri; Valentin Grabovsky; Jean-Marc Gauguet; Sara W Feigelson; Eugenia Manevich; Waldemar Kolanus; Martyn K Robinson; Donald E Staunton; Ulrich H von Andrian; Ronen Alon
Lymphocyte arrest requires instantaneous induction of an extended LFA-1 conformation mediated by endothelium-bound chemokines.
Nature immunology 2005;6(5):497-506.
2005: Isabelle Petit; Polina Goichberg; Asaf Spiegel; Amnon Peled; Chaya Brodie; Rony Seger; Arnon Nagler; Ronen Alon; Tsvee Lapidot
Atypical PKC-zeta regulates SDF-1-mediated migration and development of human CD34+ progenitor cells.
The Journal of clinical investigation 2005;115(1):168-76.
2004: Guy Cinamon; Vera Shinder; Revital Shamri; Ronen Alon
Chemoattractant signals and beta 2 integrin occupancy at apical endothelial contacts combine with shear stress signals to promote transendothelial neutrophil migration.
Journal of immunology (Baltimore, Md. : 1950) 2004;173(12):7282-91.
2004: Ravi M Rao; Travis V Betz; Deanna J Lamont; Michael B Kim; Sunil K Shaw; Richard M Froio; Françoise Baleux; Fernando Arenzana-Seisdedos; Ronen Alon; Francis W Luscinskas
Elastase release by transmigrating neutrophils deactivates endothelial-bound SDF-1alpha and attenuates subsequent T lymphocyte transendothelial migration.
The Journal of experimental medicine 2004;200(6):713-24.
2004: Kim S C Weber; Ronen Alon; Lloyd B Klickstein
Sialylation of ICAM-2 on platelets impairs adhesion of leukocytes via LFA-1 and DC-SIGN.
Inflammation 2004;28(4):177-88.
2004: Ulrich S Schwarz; Ronen Alon
L-selectin-mediated leukocyte tethering in shear flow is controlled by multiple contacts and cytoskeletal anchorage facilitating fast rebinding events.
Proceedings of the National Academy of Sciences of the United States of America 2004;101(18):6940-5.
2004: Patricia Mowery; Zhi-Qiang Yang; Eva J Gordon; Oren Dwir; Andrew G Spencer; Ronen Alon; Laura L Kiessling
Synthetic glycoprotein mimics inhibit L-selectin-mediated rolling and promote L-selectin shedding.
Chemistry & biology 2004;11(5):725-32.
2004: Suzanna Franitza; Valentin Grabovsky; Ori Wald; Ido D Weiss; Katia Beider; Michal Dagan; Merav Darash-Yahana; Arnon Nagler; Stefan Brocke; Eithan Galun; Ronen Alon; Amnon Peled
Differential usage of VLA-4 and CXCR4 by CD3+CD56+ NKT cells and CD56+CD16+ NK cells regulates their interaction with endothelial cells.
European journal of immunology 2004;34(5):1333-41.
2004: Ilya Sotnikov; Rami Hershkoviz; Valentin Grabovsky; Neta Ilan; Liora Cahalon; Israel Vlodavsky; Ronen Alon; Ofer Lider
Enzymatically quiescent heparanase augments T cell interactions with VCAM-1 and extracellular matrix components under versatile dynamic contexts.
Journal of immunology (Baltimore, Md. : 1950) 2004;172(9):5185-93.
2004: Abraham Avigdor; Polina Goichberg; Shoham Shivtiel; Ayelet Dar; Amnon Peled; Sarit Samira; Orit Kollet; Rami Hershkoviz; Ronen Alon; Izhar Hardan; Herzl Ben-Hur; David Naor; Arnon Nagler; Tsvee Lapidot
CD44 and hyaluronic acid cooperate with SDF-1 in the trafficking of human CD34+ stem/progenitor cells to bone marrow.
Blood 2004;103(8):2981-9.
2004: Tatsuo Kinashi; Memet Aker; Maya Sokolovsky-Eisenberg; Valentin Grabovsky; Chisato Tanaka; Revital Shamri; Sara W Feigelson; Amos Etzioni; Ronen Alon
LAD-III, a leukocyte adhesion deficiency syndrome associated with defective Rap1 activation and impaired stabilization of integrin bonds.
Blood 2004;103(3):1033-6.
2004: Oren Dwir; Valentin Grabovsky; Ronen Alon
Selectin avidity modulation by chemokines at subsecond endothelial contacts: a novel regulatory level of leukocyte trafficking.
Ernst Schering Research Foundation workshop 2004;(44):109-35.
2004: Guy Cinamon; Ronen Alon
Real-time in vitro assay for studying chemoattractant-triggered leukocyte transendothelial migration under physiological flow conditions.
Methods in molecular biology (Clifton, N.J.) 2004;239():233-42.
2003: Sara W Feigelson; Valentin Grabovsky; Revital Shamri; Shoshana Levy; Ronen Alon
The CD81 tetraspanin facilitates instantaneous leukocyte VLA-4 adhesion strengthening to vascular cell adhesion molecule 1 (VCAM-1) under shear flow.
The Journal of biological chemistry 2003;278(51):51203-12.
2003: Oren Dwir; Ariel Solomon; Shmuel Mangan; Geoffrey S Kansas; Ulrich S Schwarz; Ronen Alon
Avidity enhancement of L-selectin bonds by flow: shear-promoted rotation of leukocytes turn labile bonds into functional tethers.
The Journal of cell biology 2003;163(3):649-59.
2003: Ronen Alon; Amos Etzioni
LAD-III, a novel group of leukocyte integrin activation deficiencies.
Trends in immunology 2003;24(10):561-6.
2003: Ronen Alon; Valentin Grabovsky; Sara W Feigelson
Chemokine induction of integrin adhesiveness on rolling and arrested leukocytes local signaling events or global stepwise activation?
Microcirculation (New York, N.Y. : 1994) 2003;10(3-4):297-311.
2003: Ronen Alon; Memet Aker; Sara W Feigelson; Maya Sokolovsky-Eisenberg; Donald E Staunton; Guy Cinamon; Valentin Grabovsky; Revital Shamri; Amos Etzioni
A novel genetic leukocyte adhesion deficiency in subsecond triggering of integrin avidity by endothelial chemokines results in impaired leukocyte arrest on vascular endothelium under shear flow.
Blood 2003;101(11):4437-45.
2003: Guy Cinamon; Ronen Alon
A real time in vitro assay for studying leukocyte transendothelial migration under physiological flow conditions.
Journal of immunological methods 2003;273(1-2):53-62.
2002: Revital Shamri; Valentin Grabovsky; Sara W Feigelson; Oren Dwir; Yvette van Kooyk; Ronen Alon
Chemokine stimulation of lymphocyte alpha 4 integrin avidity but not of leukocyte function-associated antigen-1 avidity to endothelial ligands under shear flow requires cholesterol membrane rafts.
The Journal of biological chemistry 2002;277(42):40027-35.
2002: Oren Dwir; Douglas A Steeber; Ulrich S Schwarz; Raymond T Camphausen; Geoffrey S Kansas; Thomas F Tedder; Ronen Alon
L-selectin dimerization enhances tether formation to properly spaced ligand.
The Journal of biological chemistry 2002;277(24):21130-9.
2002: Valentin Grabovsky; Oren Dwir; Ronen Alon
Endothelial chemokines destabilize L-selectin-mediated lymphocyte rolling without inducing selectin shedding.
The Journal of biological chemistry 2002;277(23):20640-50.
2002: Ronen Alon; Sara W Feigelson
From rolling to arrest on blood vessels: leukocyte tap dancing on endothelial integrin ligands and chemokines at sub-second contacts.
Seminars in immunology 2002;14(2):93-104.
2002: Amnon Peled; Izhar Hardan; Luba Trakhtenbrot; Eyal Gur; Michal Magid; Merav Darash-Yahana; Ninette Cohen; Valentin Grabovsky; Suzanna Franitza; Orit Kollet; Ofer Lider; Ronen Alon; Gideon Rechavi; Tsvee Lapidot
Immature leukemic CD34+CXCR4+ cells from CML patients have lower integrin-dependent migration and adhesion in response to the chemokine SDF-1.
Stem cells (Dayton, Ohio) 2002;20(3):259-66.
2002: Suzanna Franitza; Orit Kollet; Alexander Brill; Gayle G Vaday; Isabelle Petit; Tsvee Lapidot; Ronen Alon; Ofer Lider
TGF-beta1 enhances SDF-1alpha-induced chemotaxis and homing of naive T cells by up-regulating CXCR4 expression and downstream cytoskeletal effector molecules.
European journal of immunology 2002;32(1):193-202.
2001: Julia Fernandez-Rodriguez; Oren Dwir; Ronen Alon; Gunnar Hansson
Tumor cell MUC1 and CD43 are glycosylated differently with sialyl-Lewis a and x epitopes and show variable interactions with E-selectin under physiological flow conditions.
Glycoconjugate journal 2001;18(11-12):925-30.
2001: Shulamit B Wallach-Dayan; Valentin Grabovsky; Jurgen Moll; Jonathan Sleeman; Peter Herrlich; Ronen Alon; David Naor
CD44-dependent lymphoma cell dissemination: a cell surface CD44 variant, rather than standard CD44, supports in vitro lymphoma cell rolling on hyaluronic acid substrate and its in vivo accumulation in the peripheral lymph nodes.
Journal of cell science 2001;114(Pt 19):3463-77.
2001: Oren Dwir; Geoffrey S Kansas; Ronen Alon
Cytoplasmic anchorage of L-selectin controls leukocyte capture and rolling by increasing the mechanical stability of the selectin tether.
The Journal of cell biology 2001;155(1):145-56.
2001: David M Rose; Valentin Grabovsky; Ronen Alon; Mark H Ginsberg
The affinity of integrin alpha(4)beta(1) governs lymphocyte migration.
Journal of immunology (Baltimore, Md. : 1950) 2001;167(5):2824-30.
2001: Ronen Alon
Encephalitogenic lymphoblast recruitment to resting CNS microvasculature: a natural immunosurveillance mechanism?
The Journal of clinical investigation 2001;108(4):517-9.
2001: Guy Cinamon; Valentin Grabovsky; Eitan Winter; Suzanna Franitza; Sara W Feigelson; Revital Shamri; Oren Dwir; Ronen Alon
Novel chemokine functions in lymphocyte migration through vascular endothelium under shear flow.
Journal of leukocyte biology 2001;69(6):860-6.
2001: Guy Cinamon; Vera Shinder; Ronen Alon
Shear forces promote lymphocyte migration across vascular endothelium bearing apical chemokines.
Nature immunology 2001;2(6):515-22.
2001: Sara W Feigelson; Valentin Grabovsky; Eitan Winter; L L Chen; R Blake Pepinsky; T Yednock; D Yablonski; Roy R Lobb; Ronen Alon
The Src kinase p56(lck) up-regulates VLA-4 integrin affinity. Implications for rapid spontaneous and chemokine-triggered T cell adhesion to VCAM-1 and fibronectin.
The Journal of biological chemistry 2001;276(17):13891-901.
2001: Anat Faber-Elmann; Valentin Grabovsky; Molly Dayan; Michael Sela; Ronen Alon; Edna Mozes
An altered peptide ligand inhibits the activities of matrix metalloproteinase-9 and phospholipase C, and inhibits T cell interactions with VCAM-1 induced in vivo by a myasthenogenic T cell epitope.
FASEB journal : official publication of the Federation of American Societies for Experimental Biology 2001;15(1):187-194.
2000: Anat Faber-Elmann; Valentin Grabovsky; Molly Dayan; Michael Sela; Ronen Alon; Edna Mozes
Cytokine profile and T cell adhesiveness to endothelial selectins: in vivo induction by a myasthenogenic T cell epitope and immunomodulation by a dual altered peptide ligand.
International immunology 2000;12(12):1651-8.
2000: Liat Flaishon; Rami Hershkoviz; Frida Lantner; Ofer Lider; Ronen Alon; Yoram Levo; Richard A Flavell; Idit Shachar
Autocrine secretion of interferon gamma negatively regulates homing of immature B cells.
The Journal of experimental medicine 2000;192(9):1381-8.
2000: Teunis B H Geijtenbeek; Daniëlle J E B Krooshoop; DA Bleijs; Sandra J van Vliet; Gerard van Duijnhoven; Valentin Grabovsky; Ronen Alon; Carl G Figdor; Yvette van Kooyk
DC-SIGN-ICAM-2 interaction mediates dendritic cell trafficking.
Nature immunology 2000;1(4):353-7.
2000: Suzanna Franitza; Rami Hershkoviz; N Kam; N Lichtenstein; Gayle G Vaday; Ronen Alon; Ofer Lider
TNF-alpha associated with extracellular matrix fibronectin provides a stop signal for chemotactically migrating T cells.
Journal of immunology (Baltimore, Md. : 1950) 2000;165(5):2738-47.
2000: Valentin Grabovsky; Sara W Feigelson; C Chen; DA Bleijs; Amnon Peled; Guy Cinamon; Françoise Baleux; Fernando Arenzana-Seisdedos; Tsvee Lapidot; Roy R Lobb; Ronen Alon
Subsecond induction of alpha4 integrin clustering by immobilized chemokines stimulates leukocyte tethering and rolling on endothelial vascular cell adhesion molecule 1 under flow conditions.
The Journal of experimental medicine 2000;192(4):495-506.
2000: Alex Sigal; DA Bleijs; Valentin Grabovsky; Sandra J van Vliet; Oren Dwir; Carl G Figdor; Yvette van Kooyk; Ronen Alon
The LFA-1 integrin supports rolling adhesions on ICAM-1 under physiological shear flow in a permissive cellular environment.
Journal of immunology (Baltimore, Md. : 1950) 2000;165(1):442-52.
2000: Yaron R Hadari; Rinat Arbel-Goren; Yifat Levy; A Amsterdam; Ronen Alon; R Zakut; Yehiel Zick
Galectin-8 binding to integrins inhibits cell adhesion and induces apoptosis.
Journal of cell science 2000;113 ( Pt 13)():2385-97.
2000: Oren Dwir; Geoffrey S Kansas; Ronen Alon
An activated L-selectin mutant with conserved equilibrium binding properties but enhanced ligand recognition under shear flow.
The Journal of biological chemistry 2000;275(25):18682-91.
2000: Amnon Peled; Orit Kollet; Tanya Ponomaryov; Isabelle Petit; Suzanna Franitza; Valentin Grabovsky; M M Slav; Arnon Nagler; Ofer Lider; Ronen Alon; Dov Zipori; Tsvee Lapidot
The chemokine SDF-1 activates the integrins LFA-1, VLA-4, and VLA-5 on immature human CD34(+) cells: role in transendothelial/stromal migration and engraftment of NOD/SCID mice.
Blood 2000;95(11):3289-96.
2000: Rinat Eshel; Alexandra Zanin; Orit Sagi-Assif; Tsipi Meshel; Nechama I Smorodinsky; Oren Dwir; Ronen Alon; R Brakenhoff; G van Dongen; Isaac P Witz
The GPI-linked Ly-6 antigen E48 regulates expression levels of the FX enzyme and of E-selectin ligands on head and neck squamous carcinoma cells.
The Journal of biological chemistry 2000;275(17):12833-40.
1999: Amnon Peled; Valentin Grabovsky; Liliana Habler; Judith Sandbank; Fernando Arenzana-Seisdedos; Isabelle Petit; Herzl Ben-Hur; Tsvee Lapidot; Ronen Alon
The chemokine SDF-1 stimulates integrin-mediated arrest of CD34(+) cells on vascular endothelium under shear flow.
The Journal of clinical investigation 1999;104(9):1199-211.
1999: Suzanna Franitza; Ronen Alon; Ofer Lider
Real-time analysis of integrin-mediated chemotactic migration of T lymphocytes within 3-D extracellular matrix-like gels.
Journal of immunological methods 1999;225(1-2):9-25.
1999: W J Sanders; Eva J Gordon; Oren Dwir; P J Beck; Ronen Alon; Laura L Kiessling
Inhibition of L-selectin-mediated leukocyte rolling by synthetic glycoprotein mimics.
The Journal of biological chemistry 1999;274(9):5271-8.
1999: Amnon Peled; Isabelle Petit; Orit Kollet; M Magid; Tanya Ponomaryov; Tamara Byk; Arnon Nagler; Herzl Ben-Hur; A Many; Leonard D Shultz; Ofer Lider; Ronen Alon; Dov Zipori; Tsvee Lapidot
Dependence of human stem cell engraftment and repopulation of NOD/SCID mice on CXCR4.
Science (New York, N.Y.) 1999;283(5403):845-8.
1999: C Chen; J L Mobley; Oren Dwir; F Shimron; Valentin Grabovsky; Roy R Lobb; Y Shimizu; Ronen Alon
High affinity very late antigen-4 subsets expressed on T cells are mandatory for spontaneous adhesion strengthening but not for rolling on VCAM-1 in shear flow.
Journal of immunology (Baltimore, Md. : 1950) 1999;162(2):1084-95.
1998: Ronen Alon; Selby Chen; Robert C Fuhlbrigge; KD Puri; Timothy A Springer
The kinetics and shear threshold of transient and rolling interactions of L-selectin with its ligand on leukocytes.
Proceedings of the National Academy of Sciences of the United States of America 1998;95(20):11631-6.
1998: Oren Dwir; F Shimron; C Chen; M S Singer; S D Rosen; Ronen Alon
GlyCAM-1 supports leukocyte rolling in flow: evidence for a greater dynamic stability of L-selectin rolling of lymphocytes than of neutrophils.
Cell adhesion and communication 1998;6(4):349-70.
1997: C Pujades; Ronen Alon; RL Yauch; A Masumoto; Linda C Burkly; C Chen; T A Springer; Roy R Lobb; Martin Helmer
Defining extracellular integrin alpha-chain sites that affect cell adhesion and adhesion strengthening without altering soluble ligand binding.
Molecular biology of the cell 1997;8(12):2647-57.
1997: Amiram Ariel; Rami Hershkoviz; Liora Cahalon; D E Williams; S K Akiyama; Kenneth M Yamada; C Chen; Ronen Alon; Tsvee Lapidot; Ofer Lider
Induction of T cell adhesion to extracellular matrix or endothelial cell ligands by soluble or matrix-bound interleukin-7.
European journal of immunology 1997;27(10):2562-70.
1997: Ronen Alon; Selby Chen; KD Puri; E B Finger; Timothy A Springer
The kinetics of L-selectin tethers and the mechanics of selectin-mediated rolling.
The Journal of cell biology 1997;138(5):1169-80.
1997: Selby Chen; Ronen Alon; Robert C Fuhlbrigge; Timothy A Springer
Rolling and transient tethering of leukocytes on antibodies reveal specializations of selectins.
Proceedings of the National Academy of Sciences of the United States of America 1997;94(7):3172-7.
1996: Ronen Alon; Robert C Fuhlbrigge; E B Finger; Timothy A Springer
Interactions through L-selectin between leukocytes and adherent leukocytes nucleate rolling adhesions on selectins and VCAM-1 in shear flow.
The Journal of cell biology 1996;135(3):849-65.
1996: Robert C Fuhlbrigge; Ronen Alon; KD Puri; J B Lowe; Timothy A Springer
Sialylated, fucosylated ligands for L-selectin expressed on leukocytes mediate tethering and rolling adhesions in physiologic flow conditions.
The Journal of cell biology 1996;135(3):837-48.
1996: R A Clark; Ronen Alon; Timothy A Springer
CD44 and hyaluronan-dependent rolling interactions of lymphocytes on tonsillar stroma.
The Journal of cell biology 1996;134(4):1075-87.
1996: C Weber; Ronen Alon; B Moser; Timothy A Springer
Sequential regulation of alpha 4 beta 1 and alpha 5 beta 1 integrin avidity by CC chemokines in monocytes: implications for transendothelial chemotaxis.
The Journal of cell biology 1996;134(4):1063-73.
1996: M W Carr; Ronen Alon; Timothy A Springer
The C-C chemokine MCP-1 differentially modulates the avidity of beta 1 and beta 2 integrins on T lymphocytes.
Immunity 1996;4(2):179-87.
1996: E B Finger; KD Puri; Ronen Alon; Michael B Lawrence; Ulrich H von Andrian; Timothy A Springer
Adhesion through L-selectin requires a threshold hydrodynamic shear.
Nature 1996;379(6562):266-9.
1995: M S Diamond; Ronen Alon; Charles A Parkos; Mark T Quinn; Timothy A Springer
Heparin is an adhesive ligand for the leukocyte integrin Mac-1 (CD11b/CD1).
The Journal of cell biology 1995;130(6):1473-82.
1995: P D Kassner; Ronen Alon; Timothy A Springer; Martin Helmer
Specialized functional properties of the integrin alpha 4 cytoplasmic domain.
Molecular biology of the cell 1995;6(6):661-74.
1995: Ronen Alon; T Feizi; C T Yuen; Robert C Fuhlbrigge; Timothy A Springer
Glycolipid ligands for selectins support leukocyte tethering and rolling under physiologic flow conditions.
Journal of immunology (Baltimore, Md. : 1950) 1995;154(10):5356-66.
1995: Ronen Alon; D A Hammer; Timothy A Springer
Lifetime of the P-selectin-carbohydrate bond and its response to tensile force in hydrodynamic flow.
Nature 1995;374(6522):539-42.
1995: Ronen Alon; P D Kassner; M W Carr; E B Finger; Martin Helmer; Timothy A Springer
The integrin VLA-4 supports tethering and rolling in flow on VCAM-1.
The Journal of cell biology 1995;128(6):1243-53.
1994: Rami Hershkoviz; Liora Cahalon; Shmuel Miron; Ronen Alon; Tamar Sapir; S K Akiyama; Kenneth M Yamada; Ofer Lider
TNF-alpha associated with fibronectin enhances phorbol myristate acetate- or antigen-mediated integrin-dependent adhesion of CD4+ T cells via protein tyrosine phosphorylation.
Journal of immunology (Baltimore, Md. : 1950) 1994;153(2):554-65.
1994: N Greenspoon; Rami Hershkoviz; Ronen Alon; E Gershonov; B Lavie; Ofer Lider
Novel psi-S-CH2 peptide-bond replacement and its utilization in the synthesis of nonpeptidic surrogates of the Leu-Asp-Val sequence that exhibit specific inhibitory activities on CD4+ T cell binding to fibronectin.
International journal of peptide and protein research 1994;43(5):417-24.
1994: Rami Hershkoviz; N Greenspoon; Yoseph A Mekori; R Hadari; Ronen Alon; G Kapustina; Ofer Lider
Inhibition of CD4+ T lymphocyte binding to fibronectin and immune-cell accumulation in inflammatory sites by non-peptidic mimetics of Arg-Gly-Asp.
Clinical and experimental immunology 1994;95(2):270-6.
1994: Ronen Alon; Liora Cahalon; Rami Hershkoviz; D Elbaz; Boris Reizis; David Wallach; S K Akiyama; Kenneth M Yamada; Ofer Lider
TNF-alpha binds to the N-terminal domain of fibronectin and augments the beta 1-integrin-mediated adhesion of CD4+ T lymphocytes to the glycoprotein.
Journal of immunology (Baltimore, Md. : 1950) 1994;152(3):1304-13.
1993: Ofer Lider; Rami Hershkoviz; Ronen Alon; N Greenspoon
Structure-function analysis of integrin-mediated cell functions by novel nonpeptidic conformational mimetics of the Arg-Gly-Asp and Leu-Asp-Val amino acid sequences.
Annals of the New York Academy of Sciences 1993;696():402-3.
1993: Ronen Alon; Edward A Bayer; Meir Wilchek
Affinity cleavage of cell surface antibodies using the avidin-biotin system.
Journal of immunological methods 1993;165(1):127-34.
1993: Rami Hershkoviz; Ronen Alon; Yoseph A Mekori; D Gilat; Liora Cahalon; A Miller; Ofer Lider
Heat-stressed CD4+ T lymphocytes: differential modulations of adhesiveness to extracellular matrix glycoproteins, proliferative responses and tumour necrosis factor-alpha secretion.
Immunology 1993;79(2):241-7.
1993: Ronen Alon; Rami Hershkoviz; Edward A Bayer; Meir Wilchek; Ofer Lider
Streptavidin blocks immune reactions mediated by fibronectin-VLA-5 recognition through an Arg-Gly-Asp mimicking site.
European journal of immunology 1993;23(4):893-8.
1993: N Greenspoon; Rami Hershkoviz; Ronen Alon; David Varon; Boris Shenkman; G Marx; S Federman; G Kapustina; Ofer Lider
Structural analysis of integrin recognition and the inhibition of integrin-mediated cell functions by novel nonpeptidic surrogates of the Arg-Gly-Asp sequence.
Biochemistry 1993;32(4):1001-8.
1993: Ronen Alon; Edward A Bayer; Meir Wilchek
Cell adhesion to streptavidin via RGD-dependent integrins.
European journal of cell biology 1993;60(1):1-11.
1992: Ronen Alon; Edward A Bayer; Meir Wilchek
Cell-adhesive properties of streptavidin are mediated by the exposure of an RGD-like RYD site.
European journal of cell biology 1992;58(2):271-9.
1992: Rami Hershkoviz; Ronen Alon; D Gilat; Ofer Lider
Activated T lymphocytes and macrophages secrete fibronectin which strongly supports cell adhesion.
Cellular immunology 1992;141(2):352-61.
1990: Edward A Bayer; J J Grootjans; Ronen Alon; Meir Wilchek
Affinity cleavage and targeted catalysis of proteins using the avidin-biotin system.
Biochemistry 1990;29(51):11274-9.
1990: Ronen Alon; Edward A Bayer; Meir Wilchek
Streptavidin contains an RYD sequence which mimics the RGD receptor domain of fibronectin.
Biochemical and biophysical research communications 1990;170(3):1236-41.