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Alan Cuthbert

This is a preview profile on BiomedExperts - the first literature-based scientific social network. It brings the right researchers together and allows them to collaborate online. Collexis and Dell provide the BiomedExperts network of +1.5 Million pre-calculated profiles free of charge to researchers worldwide.

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Cystic Fibrosis

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Electrophysiology

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Co-Publications
Name
35
MacVinish, Lesley
13
Colledge, William
13
Evans, Martin
9
Hickman, ME
8
Cox, Helen
6
Higgins, Christopher
5
Henderson, Robert
4
Gill, Deborah
4
Cope, Georgina
4
Hyde, Stephen
4
Huang, L
3
Liu, Che-Hsiung
3
Mofford, KA
3
Murthy, Meena
3
O'Shaughnessy, Kevin

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Publications

TOP 3
Joo N S; Wine J J; Cuthbert A W
Lubiprostone stimulates secretion from tracheal submucosal glands of sheep, pigs, and humans.
MacVinish L J; Cope G; Ropenga A; Cuthbert A W
Chloride transporting capability of Calu-3 epithelia following persistent knockdown of the cystic fibrosis transmembrane conductance regulator, CFTR.
Golbang Amir P; Cope Georgina; Hamad Abbas; Murthy Meena; Liu Che-Hsiung; Cuthbert Alan W; O'shaughnessy Kevin M
Regulation of the expression of the Na/Cl cotransporter by WNK4 and WNK1: evidence that accelerated dynamin-dependent endocytosis is not involved.

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All Publications

2009: Joo N S; Wine J J; Cuthbert A W
Lubiprostone stimulates secretion from tracheal submucosal glands of sheep, pigs, and humans.
American journal of physiology. Lung cellular and molecular physiology 2009;296(5):L811-24.
2007: MacVinish L J; Cope G; Ropenga A; Cuthbert A W
Chloride transporting capability of Calu-3 epithelia following persistent knockdown of the cystic fibrosis transmembrane conductance regulator, CFTR.
British journal of pharmacology 2007;150(8):1055-65.
2006: Golbang Amir P; Cope Georgina; Hamad Abbas; Murthy Meena; Liu Che-Hsiung; Cuthbert Alan W; O'shaughnessy Kevin M
Regulation of the expression of the Na/Cl cotransporter by WNK4 and WNK1: evidence that accelerated dynamin-dependent endocytosis is not involved.
American journal of physiology. Renal physiology 2006;291(6):F1369-76.
2006: Cope Georgina; Murthy Meena; Golbang Amir P; Hamad Abbas; Liu Che-Hsiung; Cuthbert Alan W; O'Shaughnessy Kevin M
WNK1 affects surface expression of the ROMK potassium channel independent of WNK4.
Journal of the American Society of Nephrology : JASN 2006;17(7):1867-74.
2006: Cuthbert Alan W
A brief history of the British Pharmacological Society.
British journal of pharmacology 2006;147 Suppl 1():S2-8.
2006: Cuthbert Alan W
The prospects of pharmacotherapy for cystic fibrosis.
Journal of the Royal Society of Medicine 2006;99 Suppl 46():30-5.
2005: Golbang Amir P; Murthy Meena; Hamad Abbas; Liu Che-Hsiung; Cope Georgina; Van't Hoff William; Cuthbert Alan; O'Shaughnessy Kevin M
A new kindred with pseudohypoaldosteronism type II and a novel mutation (564D>H) in the acidic motif of the WNK4 gene.
Hypertension 2005;46(2):295-300.
2005: Murthy Meena; Pedemonte Nicoletta; MacVinish Lesley; Galietta Luis; Cuthbert Alan
4-Chlorobenzo[F]isoquinoline (CBIQ), a novel activator of CFTR and DeltaF508 CFTR.
European journal of pharmacology 2005;516(2):118-24.
2004: Szkotak A J; Murthy M; MacVinish L J; Duszyk M; Cuthbert A W
4-Chloro-benzo[F]isoquinoline (CBIQ) activates CFTR chloride channels and KCNN4 potassium channels in Calu-3 human airway epithelial cells.
British journal of pharmacology 2004;142(3):531-42.
2004: Rungroj Nanyawan; Devonald Mark A J; Cuthbert Alan W; Reimann Frank; Akkarapatumwong Varaporn; Yenchitsomanus Pa-Thai; Bennett William M; Karet Fiona E
A novel missense mutation in AE1 causing autosomal dominant distal renal tubular acidosis retains normal transport function but is mistargeted in polarized epithelial cells.
The Journal of biological chemistry 2004;279(14):13833-8.
2003: Cuthbert A W; MacVinish L J
Mechanisms of anion secretion in Calu-3 human airway epithelial cells by 7,8-benzoquinoline.
British journal of pharmacology 2003;140(1):81-90.
2003: Cuthbert A W; Supuran C T; MacVinish L J
Bicarbonate-dependent chloride secretion in Calu-3 epithelia in response to 7,8-benzoquinoline.
The Journal of physiology 2003;551(Pt 1):79-92.
2003: Cuthbert Alan W
Benzoquinolines and chloride secretion in murine colonic epithelium.
British journal of pharmacology 2003;138(8):1528-34.
2003: Cuthbert Alan W; Fuller Will
Investigation of folding and degradation of in vitro synthesized mutant proteins in microsomes.
Methods in molecular biology (Clifton, N.J.) 2003;232():265-83.
2002: Cuthbert Alan W
Disease genes: flattery and deception.
Trends in pharmacological sciences 2002;23(11):504-9.
2001: Duszyk M; MacVinish L; Cuthbert A W
Phenanthrolines--a new class of CFTR chloride channel openers.
British journal of pharmacology 2001;134(4):853-64.
2001: MacVinish L J; Guo Y; Dixon A K; Murrell-Lagnado R D; Cuthbert A W
Xe991 reveals differences in K(+) channels regulating chloride secretion in murine airway and colonic epithelium.
Molecular pharmacology 2001;60(4):753-60.
2001: Cuthbert A W
Seventh W.D.M. Paton Memorial Lecture. The man who never was--Walter Ernest Dixon FRS.
British journal of pharmacology 2001;133(7):945-50.
2001: Cuthbert A W
Bicarbonate secretion in the murine gallbladder--lessons for the treatment of cystic fibrosis.
JOP : Journal of the pancreas 2001;2(4 Suppl):257-62.
2001: Cuthbert A W
Assessment of CFTR chloride channel openers in intact normal and cystic fibrosis murine epithelia.
British journal of pharmacology 2001;132(3):659-68.
2001: Cuthbert A W
Kinins and epithelial ion transport in the alimentary tract.
Biological chemistry 2001;382(1):57-60.
2001: MacVinish L J; Keogh J; Cuthbert A W
EBIO, an agent causing maintained epithelial chloride secretion by co-ordinate actions at both apical and basolateral membranes.
Pflügers Archiv : European journal of physiology 2001;443 Suppl 1():S127-31.
2000: Fuller W; Cuthbert A W
Post-translational disruption of the delta F508 cystic fibrosis transmembrane conductance regulator (CFTR)-molecular chaperone complex with geldanamycin stabilizes delta F508 CFTR in the rabbit reticulocyte lysate.
The Journal of biological chemistry 2000;275(48):37462-8.
2000: Hyde S C; Southern K W; Gileadi U; Fitzjohn E M; Mofford K A; Waddell B E; Gooi H C; Goddard C A; Hannavy K; Smyth S E; Egan J J; Sorgi F L; Huang L; Cuthbert A W; Evans M J; Colledge W H; Higgins C F; Webb A K; Gill D R
Repeat administration of DNA/liposomes to the nasal epithelium of patients with cystic fibrosis.
Gene therapy 2000;7(13):1156-65.
2000: McKay T R; MacVinish L J; Carpenter B; Themis M; Jezzard S; Goldin R; Pavirani A; Hickman M E; Cuthbert A W; Coutelle C
Selective in vivo transfection of murine biliary epithelia using polycation-enhanced adenovirus.
Gene therapy 2000;7(8):644-52.
1999: Cuthbert A W
Anion secretory effects of a non-peptide mimic of bradykinin (FR190997) on mouse colon epithelium.
Immunopharmacology 1999;45(1-3):191-8.
1999: Cuthbert A W; Hickman M E; Thorn P; MacVinish L J
Activation of Ca(2+)- and cAMP-sensitive K(+) channels in murine colonic epithelia by 1-ethyl-2-benzimidazolone.
The American journal of physiology 1999;277(1 Pt 1):C111-20.
1999: Cuthbert A W; Hickman M E; MacVinish L J
Formal analysis of electrogenic sodium, potassium, chloride and bicarbonate transport in mouse colon epithelium.
British journal of pharmacology 1999;126(1):358-64.
1998: MacVinish L J; Hickman M E; Mufti D A; Durrington H J; Cuthbert A W
Importance of basolateral K+ conductance in maintaining Cl- secretion in murine nasal and colonic epithelia.
The Journal of physiology 1998;510 ( Pt 1)():237-47.
1998: Curtis C M; Martin L C; Higgins C F; Colledge W H; Hickman M E; Evans M J; MacVinish L J; Cuthbert A W
Restoration by intratracheal gene transfer of bicarbonate secretion in cystic fibrosis mouse gallbladder.
The American journal of physiology 1998;274(6 Pt 1):G1053-60.
1998: Martin L C; Hickman M E; Curtis C M; MacVinish L J; Cuthbert A W
Electrogenic bicarbonate secretion in mouse gallbladder.
The American journal of physiology 1998;274(6 Pt 1):G1045-52.
1998: Cuthbert A W; Huxley C
The primary and final effector mechanisms required for kinin-induced epithelial chloride secretion.
The American journal of physiology 1998;274(3 Pt 1):G578-83.
1997: Goddard C A; Ratcliff R; Anderson J R; Glenn E; Brown S; Gill D R; Hyde S C; MacVinish L J; Huang L; Higgins C F; Cuthbert A W; Evans M J; Colledge W H
A second dose of a CFTR cDNA-liposome complex is as effective as the first dose in restoring cAMP-dependent chloride secretion to null CF mice trachea.
Gene therapy 1997;4(11):1231-6.
1997: MacVinish L J; Goddard C; Colledge W H; Higgins C F; Evans M J; Cuthbert A W
Normalization of ion transport in murine cystic fibrosis nasal epithelium using gene transfer.
The American journal of physiology 1997;273(2 Pt 1):C734-40.
1997: Manson A L; Trezise A E; MacVinish L J; Kasschau K D; Birchall N; Episkopou V; Vassaux G; Evans M J; Colledge W H; Cuthbert A W; Huxley C
Complementation of null CF mice with a human CFTR YAC transgene.
The EMBO journal 1997;16(14):4238-49.
1997: Teather S; Cuthbert A W
Induction of bradykinin B1 receptors in rat colonic epithelium.
British journal of pharmacology 1997;121(5):1005-11.
1997: Cuthbert A W; Teather S
Expression of bradykinin B1 receptors in colonic epithelia.
Immunopharmacology 1997;36(2-3):149-52.
1997: Gill D R; Southern K W; Mofford K A; Seddon T; Huang L; Sorgi F; Thomson A; MacVinish L J; Ratcliff R; Bilton D; Lane D J; Littlewood J M; Webb A K; Middleton P G; Colledge W H; Cuthbert A W; Evans M J; Higgins C F; Hyde S C
A placebo-controlled study of liposome-mediated gene transfer to the nasal epithelium of patients with cystic fibrosis.
Gene therapy 1997;4(3):199-209.
1997: MacVinish L J; Gill D R; Hyde S C; Mofford K A; Evans M J; Higgins C F; Colledge W H; Huang L; Sorgi F; Ratcliff R; Cuthbert A W
Chloride secretion in the trachea of null cystic fibrosis mice: the effects of transfection with pTrial10-CFTR2.
The Journal of physiology 1997;499 ( Pt 3)():677-87.
1995: Colledge W H; Abella B S; Southern K W; Ratcliff R; Jiang C; Cheng S H; MacVinish L J; Anderson J R; Cuthbert A W; Evans M J
Generation and characterization of a delta F508 cystic fibrosis mouse model.
Nature genetics 1995;10(4):445-52.
1995: Cuthbert A W; Halstead J; Ratcliff R; Colledge W H; Evans M J
The genetic advantage hypothesis in cystic fibrosis heterozygotes: a murine study.
The Journal of physiology 1995;482 ( Pt 2)():449-54.
1994: Cuthbert A W; MacVinish L J; Hickman M E; Ratcliff R; Colledge W H; Evans M J
Ion-transporting activity in the murine colonic epithelium of normal animals and animals with cystic fibrosis.
Pflügers Archiv : European journal of physiology 1994;428(5-6):508-15.
1994: Cuthbert A W; Evans M J; Colledge W H; MacVinish L J; Ratcliff R
Kinin-stimulated chloride secretion in mouse colon requires the participation of CFTR chloride channels.
Brazilian journal of medical and biological research = Revista brasileira de pesquisas médicas e biológicas / Sociedade Brasileira de Biofísica ... [et al.] 1994;27(8):1905-10.
1994: Cuthbert A W; Hickman M E; MacVinish L J; Evans M J; Colledge W H; Ratcliff R; Seale P W; Humphrey P P
Chloride secretion in response to guanylin in colonic epithelial from normal and transgenic cystic fibrosis mice.
British journal of pharmacology 1994;112(1):31-6.
1993: Ratcliff R; Evans M J; Cuthbert A W; MacVinish L J; Foster D; Anderson J R; Colledge W H
Production of a severe cystic fibrosis mutation in mice by gene targeting.
Nature genetics 1993;4(1):35-41.
1993: Bailly C; Cuthbert A W; Gentle D; Knowles M R; Waring M J
Sequence-selective binding of amiloride to DNA.
Biochemistry 1993;32(10):2514-24.
1993: MacVinish L J; Reancharoen T; Cuthbert A W
Kinin-induced chloride permeability changes in colony 29 epithelia estimated from 125I- efflux and MEQ fluorescence.
British journal of pharmacology 1993;108(2):469-78.
1993: MacVinish L J; Pickles R J; Cuthbert A W
Cyclic AMP and Ca2+ interactions affecting epithelial chloride secretion in human cultured colonic epithelia.
British journal of pharmacology 1993;108(2):462-8.
1993: Henderson R M; Cuthbert A W
Activation of ion channels by lysylbradykinin in the HCA-7 colony 29 human adenocarcinoma cell line.
British journal of pharmacology 1993;108(2):479-83.
1992: Cuthbert A W; MacVinish L J; Pickles R J
Antagonism of kinin effects on epithelial by Hoe 140: apparently competitive and non-competitive interactions.
British journal of pharmacology 1992;107(3):797-802.
1992: Pickles R J; Cuthbert A W
Failure of thapsigargin to alter ion transport in human sweat gland epithelia while intracellular Ca2+ concentration is raised.
The Journal of biological chemistry 1992;267(21):14818-25.
1992: Sheth T R; Henderson R M; Hladky S B; Cuthbert A W
Ion channel formation by duramycin.
Biochimica et biophysica acta 1992;1107(1):179-85.
1992: Henderson R M; Ashford M L; MacVinish L J; Cuthbert A W
Chloride channels and anion fluxes in a human colonic epithelium (HCA-7).
British journal of pharmacology 1992;106(1):109-14.
1992: Cuthbert A W; Cox H M
Immediate hypersensitivity reactions in epithelia. Insights from reconstructed tissues.
Annals of the New York Academy of Sciences 1992;664():335-45.
1992: Cuthbert A W; MacVinish L J; Henderson R
Chloride conductance changes in cultured colonic epithelium induced by kinins.
Agents and actions. Supplements 1992;38 ( Pt 2)():65-72.
1991: Roberts M; Hladky S B; Pickles R J; Cuthbert A W
Stimulation of sodium transport by duramycin in cultured human colonic epithelia.
The Journal of pharmacology and experimental therapeutics 1991;259(3):1050-8.
1991: Henderson R M; Cuthbert A W
An outward-rectifying potassium channel in primary cultures of sweat glands from cystic fibrosis subjects.
Biochimica et biophysica acta 1991;1097(3):219-23.
1991: Pickles R J; Brayden D J; Cuthbert A W
Synchronous transporting activity in epithelial cells in relation to intracellular calcium concentration.
Proceedings. Biological sciences / The Royal Society 1991;245(1312):53-8.
1991: Pickles R J; Cuthbert A W
Relation of anion secretory activity to intracellular Ca2+ in response to lysylbradykinin and histamine in a cultured human colonic epithelium.
European journal of pharmacology 1991;199(1):77-91.
1991: Henderson R M; Cuthbert A W
A high-conductance Ca(2+)-activated K+ channel in cultured human eccrine sweat gland cells.
Pflügers Archiv : European journal of physiology 1991;418(3):271-5.
1991: Brayden D J; Pickles R J; Cuthbert A W
Ion transport in cultured epithelia from human sweat glands: comparison of normal and cystic fibrosis tissues.
British journal of pharmacology 1991;102(1):57-64.
1990: Cox H M; Cuthbert A W
The effects of neuropeptide Y and its fragments upon basal and electrically stimulated ion secretion in rat jejunum mucosa.
British journal of pharmacology 1990;101(2):247-52.
1990: Ferrar J A; Cuthbert A W; Cox H M
The antisecretory effects of somatostatin and analogues in rat descending colon mucosa.
European journal of pharmacology 1990;184(2-3):295-303.
1990: Brayden D J; Cuthbert A W
A novel method for culturing sweat gland epithelia: comparison of normal and cystic fibrosis tissues.
British journal of clinical pharmacology 1990;29(2):235-8.
1990: Cuthbert A W; Brayden D J; Dunne A; Smyth R L; Wallwork J
Altered sensitivity to amiloride in cystic fibrosis. Observations using cultured sweat glands.
British journal of clinical pharmacology 1990;29(2):227-34.
1989: Brayden D J; Hanley M R; Thastrup O; Cuthbert A W
Thapsigargin, a new calcium-dependent epithelial anion secretagogue.
British journal of pharmacology 1989;98(3):809-16.
1989: Cox H M; Cuthbert A W
Secretory actions of vasoactive intestinal polypeptide, peptide histidine isoleucine and helodermin in rat small intestine: the effects of putative VIP antagonists upon VIP-induced ion secretion.
Regulatory peptides 1989;26(2):127-35.
1989: Cox H M; Ferrar J A; Cuthbert A W
Effects of alpha- and beta-calcitonin gene-related peptides upon ion transport in rat descending colon.
British journal of pharmacology 1989;97(4):996-8.
1989: Cox H M; Cuthbert A W
Antisecretory activity of the alpha 2-adrenoceptor agonist, xylazine in rat jejunal epithelium.
Naunyn-Schmiedeberg's archives of pharmacology 1989;339(6):669-74.
1989: Cuthbert A W; MacVinish L J
Diversity of kinin effects on transporting epithelia.
Advances in experimental medicine and biology 1989;247A():105-11.
1988: Brayden D J; Cuthbert A W; Lee C M
Human eccrine sweat gland epithelial cultures express ductal characteristics.
The Journal of physiology 1988;405():657-75.
1988: Cox H M; Cuthbert A W
Neuropeptide Y antagonises secretagogue evoked chloride transport in rat jejunal epithelium.
Pflügers Archiv : European journal of physiology 1988;413(1):38-42.
1988: Cox H M; Cuthbert A W; Håkanson R; Wahlestedt C
The effect of neuropeptide Y and peptide YY on electrogenic ion transport in rat intestinal epithelia.
The Journal of physiology 1988;398():65-80.
1988: Baron D A; Baird A W; Cuthbert A W; Margolius H S
Intestinal anaphylaxis: rapid changes in mucosal ion transport and morphology.
The American journal of physiology 1988;254(3 Pt 1):G307-14.
1987: Baird A W; Cuthbert A W
Neuronal involvement in type 1 hypersensitivity reactions in gut epithelia.
British journal of pharmacology 1987;92(3):647-55.
1987: Baird A W; Cuthbert A W; MacVinish L J
Type 1 hypersensitivity reactions in reconstructed tissues using syngeneic cell types.
British journal of pharmacology 1987;91(4):857-69.
1987: Cuthbert A W; Egléme C; Greenwood H; Hickman M E; Kirkland S C; MacVinish L J
Calcium- and cyclic AMP-dependent chloride secretion in human colonic epithelia.
British journal of pharmacology 1987;91(3):503-15.
1987: Cuthbert A W; Baird A W
Multiple mediators of type I hypersensitivity reactions in epithelia.
The American journal of physiology 1987;252(3 Pt 1):G443-4.
1987: Baird A W; Barclay W S; Blazer-Yost B L; Cuthbert A W
Affinity purified immunoglobulin G transfers immediate hypersensitivity to guinea pig colonic epithelium in vitro.
Gastroenterology 1987;92(3):635-42.
1986: Cuthbert A W; MacVinish L J
Transporting epithelia as targets for kinin effects.
Advances in experimental medicine and biology 1986;198 Pt A():203-10.
1985: Cuthbert A W; George A M; MacVinish L
Kinin effects on electrogenic ion transport in primary cultures of pig renal papillary collecting tubule cells.
The American journal of physiology 1985;249(3 Pt 2):F439-47.
1985: Cuthbert A W; Kirkland S C; MacVinish L J
Kinin effects on ion transport in monolayers of HCA-7 cells, a line from a human colonic adenocarcinoma.
British journal of pharmacology 1985;86(1):3-5.
1985: Baird A W; Cuthbert A W; Pearce F L
Immediate hypersensitivity reactions in epithelia from rats infected with Nippostrongylus brasiliensis.
British journal of pharmacology 1985;85(4):787-95.
1985: Baird A W; Cuthbert A W
Changed sensitivity to antigen in a gut epithelium treated with bile salts.
British journal of pharmacology 1985;84(3):653-6.
1984: Baird A W; Coombs R R; McLaughlan P; Cuthbert A W
Immediate hypersensitivity reactions to cow milk proteins in isolated epithelium from ileum of milk-drinking guinea-pigs: comparisons with colonic epithelia.
International archives of allergy and applied immunology 1984;75(3):255-63.
1983: Cuthbert A W; McLaughlan P; Coombs R R
Immediate hypersensitivity reaction to beta-lactoglobulin in the epithelium lining the colon of guinea pigs fed cows' milk.
International archives of allergy and applied immunology 1983;72(1):34-40.

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