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Osamu Cynshi

Research Profile

Chemicals & Drugs

Physiology

Lipid Peroxidation

Living Beings

Phenomena

Oxidation-Reduction

Disorders

Procedures

High Pressure Liquid Chromatography

Co-author Network

Publications

TOP 3
Osamu Cynshi; Kunio Tamura; Etsuo Niki
Design, synthesis, and action of antiatherogenic antioxidants.
Yasukazu Yoshida; Nanako Itoh; Mieko Hayakawa; Yoko Habuchi; Yoshiro Saito; Yoshitane Tsukamoto; Osamu Cynshi; Kou-ichi Jishage; Hiroyuki Arai; Etsuo Niki
The role of alpha-tocopherol in motor hypofunction with aging in alpha-tocopherol transfer protein knockout mice as assessed by oxidative stress biomarkers.
Ken-ichi Ozaki; Mitsu Onoma; Hiroyasu Muramatsu; Hirokazu Sudo; Shoshin Yoshida; Rie Shiokawa; Kenji Yogo; Kenshi Kamei; Osamu Cynshi; Osamu Kuromaru; Theo L Peeters; Hisanori Takanashi
An orally active motilin receptor antagonist, MA-2029, inhibits motilin-induced gastrointestinal motility, increase in fundic tone, and diarrhea in conscious dogs without affecting gastric emptying.

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All Publications

2010: Osamu Cynshi; Kunio Tamura; Etsuo Niki
Design, synthesis, and action of antiatherogenic antioxidants.
Methods in molecular biology (Clifton, N.J.) 2010;610():91-107.
2010: Yasukazu Yoshida; Nanako Itoh; Mieko Hayakawa; Yoko Habuchi; Yoshiro Saito; Yoshitane Tsukamoto; Osamu Cynshi; Kou-ichi Jishage; Hiroyuki Arai; Etsuo Niki
The role of alpha-tocopherol in motor hypofunction with aging in alpha-tocopherol transfer protein knockout mice as assessed by oxidative stress biomarkers.
The Journal of nutritional biochemistry 2010;21(1):66-76.
2009: Ken-ichi Ozaki; Mitsu Onoma; Hiroyasu Muramatsu; Hirokazu Sudo; Shoshin Yoshida; Rie Shiokawa; Kenji Yogo; Kenshi Kamei; Osamu Cynshi; Osamu Kuromaru; Theo L Peeters; Hisanori Takanashi
An orally active motilin receptor antagonist, MA-2029, inhibits motilin-induced gastrointestinal motility, increase in fundic tone, and diarrhea in conscious dogs without affecting gastric emptying.
European journal of pharmacology 2009;615(1-3):185-92.
2009: Hisanori Takanashi; Osamu Cynshi
Motilides: a long and winding road: lessons from mitemcinal (GM-611) on diabetic gastroparesis.
Regulatory peptides 2009;155(1-3):18-23.
2008: Hirokazu Sudo; Shoshin Yoshida; Ken-ichi Ozaki; Hiroyasu Muramatsu; Mitsu Onoma; Kenji Yogo; Kenshi Kamei; Osamu Cynshi; Osamu Kuromaru; Theo L Peeters; Hisanori Takanashi
Oral administration of MA-2029, a novel selective and competitive motilin receptor antagonist, inhibits motilin-induced intestinal contractions and visceral pain in rabbits.
European journal of pharmacology 2008;581(3):296-305.
2008: Yasukazu Yoshida; Mieko Hayakawa; Osamu Cynshi; Kou-ichi Jishage; Etsuo Niki
Acceleration of lipid peroxidation in alpha-tocopherol transfer protein-knockout mice following the consumption of drinking water containing a radical initiator.
Journal of oleo science 2008;57(10):577-83.
2007: Yasukazu Yoshida; Mieko Hayakawa; Nanako Itoh; Yoko Habuchi; Ruriko Inoue; Zhi-Hua Chen; Jiaofei Cao; Osamu Cynshi; Kou-ichi Jishage; Etsuo Niki
Antioxidant effects of 2,3-dihydro-5-hydroxy-4,6-di-tert-butyl-2,2-dipentylbenzofuran and alpha-tocopherol in hyperlipidemic mice as evaluated by hydroxyoctadecadienoic acid and 7-hydroxycholesterol.
Biochemical pharmacology 2007;74(7):1010-9.
2007: Masaki Tanito; Yasukazu Yoshida; Sachiko Kaidzu; Zhi-Hua Chen; Osamu Cynshi; Kou-ichi Jishage; Etsuo Niki; Akihiro Ohira
Acceleration of age-related changes in the retina in alpha-tocopherol transfer protein null mice fed a Vitamin E-deficient diet.
Investigative ophthalmology & visual science 2007;48(1):396-404.
2006: Cacang Suarna; Ben J Wu; Katherine Choy; Trevor Mori; Kevin D Croft; Osamu Cynshi; Roland Stocker
Protective effect of vitamin E supplements on experimental atherosclerosis is modest and depends on preexisting vitamin E deficiency.
Free radical biology & medicine 2006;41(5):722-30.
2006: Nanako Itoh; Yoshinori Masuo; Yasukazu Yoshida; Osamu Cynshi; Kou-ichi Jishage; Etsuo Niki
gamma-Tocopherol attenuates MPTP-induced dopamine loss more efficiently than alpha-tocopherol in mouse brain.
Neuroscience letters 2006;403(1-2):136-40.
2006: Yasukazu Yoshida; Nanako Itoh; Mieko Hayakawa; Yoko Habuchi; Ruriko Inoue; Zhi-Hua Chen; Jiaofei Cao; Osamu Cynshi; Etsuo Niki
Lipid peroxidation in mice fed a choline-deficient diet as evaluated by total hydroxyoctadecadienoic acid.
Nutrition (Burbank, Los Angeles County, Calif.) 2006;22(3):303-11.
2005: Yasukazu Yoshida; Nanako Itoh; Mieko Hayakawa; Rosaria Piga; Osamu Cynshi; Kou-ichi Jishage; Etsuo Niki
Lipid peroxidation induced by carbon tetrachloride and its inhibition by antioxidant as evaluated by an oxidative stress marker, HODE.
Toxicology and applied pharmacology 2005;208(1):87-97.
2005: Ryo Yamauchi; Peter T Southwell-Keely; Cacang Suarna; Sangeeta Ray; Mark Raftery; Osamu Cynshi; Roland Stocker
Characterization of the oxidation products of BO-653 formed during peroxyl radical-mediated oxidation of human plasma.
Free radical biology & medicine 2005;38(1):32-40.
2004: Nanako Itoh; Yasukazu Yoshida; Mieko Hayakawa; Noriko Noguchi; Tatsuhiko Kodama; Osamu Cynshi; Etsuo Niki
Inhibition of plasma lipid peroxidation by anti-atherogenic antioxidant BO-653, 2,3-dihydro-5-hydroxy-4,6-di-tert-butyl-2,2-dipentylbenzofuran.
Biochemical pharmacology 2004;68(5):813-8.
2003: Kunio Tamura; Yoshiaki Kato; Akira Ishikawa; Yasuharu Kato; Motomu Himori; Mitsutaka Yoshida; Yoshiaki Takashima; Tsukasa Suzuki; Yoshiki Kawabe; Osamu Cynshi; Tatsuhiko Kodama; Etsuo Niki; Makoto Shimizu
Design and synthesis of 4,6-di-tert-butyl-2,3-dihydro-5-benzofuranols as a novel series of antiatherogenic antioxidants.
Journal of medicinal chemistry 2003;46(14):3083-93.
2002: Yasukazu Yoshida; Noriko Noguchi; Akira Watanabe; Yoshihide Iwaki; Makoto Yanagisawa; Tatsuhiko Kodama; Osamu Cynshi; Etsuo Niki
Antioxidant action of 2,2,4,6-tetra-substituted 2,3-dihydro-5-hydroxybenzofuran against lipid peroxidation: effects of substituents and side chain.
Free radical research 2002;36(11):1171-8.
2002: Kenji Inoue; Osamu Cynshi; Yoshiki Kawabe; Minako Nakamura; Katsumi Miyauchi; Tohoru Kimura; Hiroyuki Daida; Takao Hamakubo; Hiroshi Yamaguchi; Tatsuhiko Kodama
Effect of BO-653 and probucol on c-MYC and PDGF-A messenger RNA of the iliac artery after balloon denudation in cholesterol-fed rabbits.
Atherosclerosis 2002;161(2):353-63.
1998: Osamu Cynshi; Y Kawabe; T Suzuki; Y Takashima; H Kaise; M Nakamura; Y Ohba; Y Kato; K Tamura; A Hayasaka; A Higashida; H Sakaguchi; M Takeya; K Takahashi; K Inoue; Noriko Noguchi; Etsuo Niki; T Kodama
Antiatherogenic effects of the antioxidant BO-653 in three different animal models.
Proceedings of the National Academy of Sciences of the United States of America 1998;95(17):10123-8.
1997: Noriko Noguchi; Yuri Okimoto; J Tsuchiya; Osamu Cynshi; Tsunenori Kodama; Etsuo Niki
Inhibition of oxidation of low-density lipoprotein by a novel antioxidant, BO-653, prepared by theoretical design.
Archives of biochemistry and biophysics 1997;347(1):141-7.
1997: Noriko Noguchi; Y Iwaki; Michio Takahashi; E Komuro; Y Kato; K Tamura; Osamu Cynshi; Tsunenori Kodama; Etsuo Niki
2,3-Dihydro-5-hydroxy-2,2-dipentyl-4,6-di-tert-butylbenzofuran: design and evaluation as a novel radical-scavenging antioxidant against lipid peroxidation.
Archives of biochemistry and biophysics 1997;342(2):236-43.
1997: H Suzuki; Y Kurihara; M Takeya; Nobuo Kamada; M Kataoka; Kou-ichi Jishage; Otoya Ueda; H Sakaguchi; T Higashi; T Suzuki; Y Takashima; Y Kawabe; Osamu Cynshi; Y Wada; M Honda; H Kurihara; H Aburatani; T Doi; A Matsumoto; S Azuma; T Noda; Y Toyoda; H Itakura; Y Yazaki; Tsunenori Kodama
A role for macrophage scavenger receptors in atherosclerosis and susceptibility to infection.
Nature 1997;386(6622):292-6.
1995: Osamu Cynshi; Y Takashima; Y Katoh; K Tamura; M Sato; Y Fujita
Action of phenolic antioxidants on various active oxygen species.
Journal of bioluminescence and chemiluminescence 1995;10(5):261-9.
1994: Y Kawabe; Osamu Cynshi; Y Takashima; T Suzuki; Y Ohba; T Kodama
Oxidation-induced aggregation of rabbit low-density lipoprotein by azo initiator.
Archives of biochemistry and biophysics 1994;310(2):489-96.
1994: Osamu Cynshi; Y Takashima; T Suzuki; Y Kawabe; Y Ohba; T Kodama
Characterization of aggregated low density lipoproteins induced by copper-catalyzed oxidation.
Journal of atherosclerosis and thrombosis 1994;1(2):87-97.
1991: Osamu Cynshi; K Satoh; Y Shimonaka; K Hattori; H Nomura; N Imai; K Hirashima
Reduced response to granulocyte colony-stimulating factor in W/Wv and Sl/Sld mice.
Leukemia 1991;5(1):75-7.
1990: Osamu Cynshi; Y Shimonaka; M Higuchi; N Imai; H Suzuki; M Togashi; M T Okamoto; K Hirashima
Effects of recombinant human erythropoietin on haemolytic anaemia in mice.
British journal of haematology 1990;76(3):414-9.
1990: Osamu Cynshi; M Saitoh; F Cynshi; M Tanemura; S Hata; M Nakano
Anti-oxidative profile of lobenzarit disodium (CCA).
Biochemical pharmacology 1990;40(9):2117-22.
1990: Osamu Cynshi; K Satoh; M Higuchi; N Imai; T Kawaguchi; K Hirashima
Effects of recombinant human erythropoietin on anaemic W/Wv and Sl/Sld mice.
British journal of haematology 1990;75(3):319-24.