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Christian Czech

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Katrin Schuessel; Stephanie Schäfer; Thomas A Bayer; Christian Czech; Laurent Pradier; Franz Müller-Spahn; Walter E Müller; Anne Eckert
Impaired Cu/Zn-SOD activity contributes to increased oxidative damage in APP transgenic mice.
Uta Keil; Astrid Bonert; Celio A Marques; Isabel Scherping; Jörg Weyermann; Joanna B Strosznajder; Franz Müller-Spahn; Christian Haass; Christian Czech; Laurent Pradier; Walter E Müller; Anne Eckert
Amyloid beta-induced changes in nitric oxide production and mitochondrial activity lead to apoptosis.
Christoph Schmitz; Bart P F Rutten; Andrea Pielen; Stephanie Schäfer; Oliver Wirths; Günter Tremp; Christian Czech; Véronique Blanchard; Gerd Multhaup; Payam Rezaie; Hubert Korr; Harry W M Steinbusch; Laurent Pradier; Thomas A Bayer
Hippocampal neuron loss exceeds amyloid plaque load in a transgenic mouse model of Alzheimer's disease.

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All Publications

2005: Katrin Schuessel; Stephanie Schäfer; Thomas A Bayer; Christian Czech; Laurent Pradier; Franz Müller-Spahn; Walter E Müller; Anne Eckert
Impaired Cu/Zn-SOD activity contributes to increased oxidative damage in APP transgenic mice.
Neurobiology of disease 2005;18(1):89-99.
2004: Uta Keil; Astrid Bonert; Celio A Marques; Isabel Scherping; Jörg Weyermann; Joanna B Strosznajder; Franz Müller-Spahn; Christian Haass; Christian Czech; Laurent Pradier; Walter E Müller; Anne Eckert
Amyloid beta-induced changes in nitric oxide production and mitochondrial activity lead to apoptosis.
The Journal of biological chemistry 2004;279(48):50310-20.
2004: Christoph Schmitz; Bart P F Rutten; Andrea Pielen; Stephanie Schäfer; Oliver Wirths; Günter Tremp; Christian Czech; Véronique Blanchard; Gerd Multhaup; Payam Rezaie; Hubert Korr; Harry W M Steinbusch; Laurent Pradier; Thomas A Bayer
Hippocampal neuron loss exceeds amyloid plaque load in a transgenic mouse model of Alzheimer's disease.
The American journal of pathology 2004;164(4):1495-502.
2003: Véronique Blanchard; Saliha Moussaoui; Christian Czech; Nathalie Touchet; Bruno Bonici; Michel Planche; Thierry Canton; Iness Jedidi; Micheline Gohin; Oliver Wirths; Thomas A Bayer; Dominique Langui; Charles Duyckaerts; Günter Tremp; Laurent Pradier
Time sequence of maturation of dystrophic neurites associated with Abeta deposits in APP/PS1 transgenic mice.
Experimental neurology 2003;184(1):247-63.
2003: Katharina Schindowski; Tilman Kratzsch; Jürgen Peters; Barbara Steiner; Silke Leutner; Nathalie Touchet; Konrad Maurer; Christian Czech; Laurent Pradier; Lutz Frölich; Walter E Müller; Anne Eckert
Impact of aging: sporadic, and genetic risk factors on vulnerability to apoptosis in Alzheimer's disease.
Neuromolecular medicine 2003;4(3):161-78.
2002: Faraj Terro; Christian Czech; Françoise Esclaire; Wassim Elyaman; Catherine Yardin; Marie-Claire Baclet; Nathalie Touchet; Günter Tremp; Laurent Pradier; Jacques Hugon
Neurons overexpressing mutant presenilin-1 are more sensitive to apoptosis induced by endoplasmic reticulum-Golgi stress.
Journal of neuroscience research 2002;69(4):530-9.
2002: Oliver Wirths; Gerd Multhaup; Christian Czech; Nicole Feldmann; Véronique Blanchard; Günter Tremp; Konrad Beyreuther; Laurent Pradier; Thomas A Bayer
Intraneuronal APP/A beta trafficking and plaque formation in beta-amyloid precursor protein and presenilin-1 transgenic mice.
Brain pathology (Zurich, Switzerland) 2002;12(3):275-86.
2001: Oliver Wirths; Gerd Multhaup; Christian Czech; Véronique Blanchard; Günter Tremp; Laurent Pradier; Konrad Beyreuther; Thomas A Bayer
Reelin in plaques of beta-amyloid precursor protein and presenilin-1 double-transgenic mice.
Neuroscience letters 2001;316(3):145-8.
2001: Oliver Wirths; Gerd Multhaup; Christian Czech; Véronique Blanchard; Saliha Moussaoui; Günter Tremp; Laurent Pradier; Konrad Beyreuther; Thomas A Bayer
Intraneuronal Abeta accumulation precedes plaque formation in beta-amyloid precursor protein and presenilin-1 double-transgenic mice.
Neuroscience letters 2001;306(1-2):116-20.
2001: Anne Eckert; Katharina Schindowski; Silke Leutner; C Luckhaus; Nathalie Touchet; Christian Czech; Walter E Müller
Alzheimer's disease-like alterations in peripheral cells from presenilin-1 transgenic mice.
Neurobiology of disease 2001;8(2):331-42.
2001: Thomas A Bayer; Oliver Wirths; K Majtényi; Tobias Hartmann; Gerd Multhaup; Konrad Beyreuther; Christian Czech
Key factors in Alzheimer's disease: beta-amyloid precursor protein processing, metabolism and intraneuronal transport.
Brain pathology (Zurich, Switzerland) 2001;11(1):1-11.
2000: Silke Leutner; Christian Czech; Katharina Schindowski; Nathalie Touchet; Anne Eckert; Walter E Müller
Reduced antioxidant enzyme activity in brains of mice transgenic for human presenilin-1 with single or multiple mutations.
Neuroscience letters 2000;292(2):87-90.
2000: E Lopez-Perez; Cécile Dumanchin; Christian Czech; Dominique Campion; Bruno Goud; Laurent Pradier; Thierry Frebourg; Frédéric Checler
Overexpression of Rab11 or constitutively active Rab11 does not affect sAPPalpha and Abeta secretions by wild-type and Swedish mutated betaAPP-expressing HEK293 cells.
Biochemical and biophysical research communications 2000;275(3):910-5.
2000: MA Colle; Charles Duyckaerts; A Laquerrière; Laurent Pradier; Christian Czech; Frédéric Checler; JEAN-JACQUES HAUW
Laminar specific loss of isocortical presenilin 1 immunoreactivity in Alzheimer's disease. Correlations with the amyloid load and the density of tau-positive neurofibrillary tangles.
Neuropathology and applied neurobiology 2000;26(2):117-23.
2000: Christian Czech; Günter Tremp; Laurent Pradier
Presenilins and Alzheimer's disease: biological functions and pathogenic mechanisms.
Progress in neurobiology 2000;60(4):363-84.
2000: Jean-Noël Octave; R Essalmani; Bernadette Tasiaux; J Menager; Christian Czech; Luc Mercken
The role of presenilin-1 in the gamma-secretase cleavage of the amyloid precursor protein of Alzheimer's disease.
The Journal of biological chemistry 2000;275(3):1525-8.
1999: Cécile Dumanchin; Christian Czech; Dominique Campion; Marie-Hélène Cuif; T Poyot; Cosette Martin; Frédéric Charbonnier; Bruno Goud; Laurent Pradier; Thierry Frebourg
Presenilins interact with Rab11, a small GTPase involved in the regulation of vesicular transport.
Human molecular genetics 1999;8(7):1263-9.
1999: Laurent Pradier; N Carpentier; L Delalonde; N Clavel; M D Bock; Luc BUEE; Luc Mercken; B Tocqué; Christian Czech
Mapping the APP/presenilin (PS) binding domains: the hydrophilic N-terminus of PS2 is sufficient for interaction with APP and can displace APP/PS1 interaction.
Neurobiology of disease 1999;6(1):43-55.
1998: A Calenda; N Mestre-Francés; Christian Czech; Laurent Pradier; A Petter; M Perret; Nöelle Bons; M Bellis
Cloning of the presenilin 2 cDNA and its distribution in brain of the primate, Microcebus murinus: coexpression with betaAPP and Tau proteins.
Neurobiology of disease 1998;5(5):323-33.
1998: Christian Czech; M Lesort; Günter Tremp; Faraj Terro; Véronique Blanchard; Brigitte Schombert; N Carpentier; S Dreisler; Bruno Bonici; A Takashima; Saliha Moussaoui; Jacques Hugon; Laurent Pradier
Characterization of human presenilin 1 transgenic rats: increased sensitivity to apoptosis in primary neuronal cultures.
Neuroscience 1998;87(2):325-36.
1998: AF Macq; Christian Czech; R Essalmani; Jean-Pierre Brion; Anne Maron; Luc Mercken; Laurent Pradier; Jean-Noël Octave
The long term adenoviral expression of the human amyloid precursor protein shows different secretase activities in rat cortical neurons and astrocytes.
The Journal of biological chemistry 1998;273(44):28931-6.
1998: C Apert; Christian Czech; Annie Faivre-Bauman; Catherine Loudes; Laurent Pradier; Jacques Epelbaum
Profiles of amyloid precursor and presenilin 2-like proteins are correlated during development of the mouse hypothalamus.
Journal of neuroendocrinology 1998;10(2):101-9.
1997: Christian Czech; P Delaère; AF Macq; Michel Reibaud; S Dreisler; Nathalie Touchet; Brigitte Schombert; M Mazadier; Luc Mercken; M Theisen; Laurent Pradier; Jean-Noël Octave; Konrad Beyreuther; Günter Tremp
Proteolytical processing of mutated human amyloid precursor protein in transgenic mice.
Brain research. Molecular brain research 1997;47(1-2):108-16.
1997: Véronique Blanchard; Christian Czech; Bruno Bonici; N Clavel; M Gohin; K Dalet; F Revah; Laurent Pradier; Assunta Imperato; Saliha Moussaoui
Immunohistochemical analysis of presenilin 2 expression in the mouse brain: distribution pattern and co-localization with presenilin 1 protein.
Brain research 1997;758(1-2):209-17.
1996: A Calenda; N Mestre-Francés; Christian Czech; Laurent Pradier; A Petter; Nöelle Bons; M Bellis
Molecular cloning, sequencing, and brain expression of the presenilin 1 gene in Microcebus murinus.
Biochemical and biophysical research communications 1996;228(2):430-9.
1996: D Quarteronet; Laurent Pradier; Christian Czech; L Delalonde; M C Burgevin; A Doble; François Petitet
Localization of presenilin-1 mRNA in rat brain.
Neuroreport 1996;7(15-17):2587-91.
1996: Saliha Moussaoui; Christian Czech; Laurent Pradier; Véronique Blanchard; Bruno Bonici; M Gohin; Assunta Imperato; F Revah
Immunohistochemical analysis of presenilin-1 expression in the mouse brain.
FEBS letters 1996;383(3):219-22.