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Michael Czech

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TOP 3
Myriam Aouadi; Jessica L Cohen; Shinya U Amano; Sarah M C Nicoloro; Michaela Tencerova; Pranitha Vangala; Joseph C Yawe; Michael P Czech
Gene silencing in adipose tissue macrophages regulates whole-body metabolism in obese mice.
Michael P Czech; D J Pedersen; M Tencerova; Myriam Aouadi
Insulin signalling mechanisms for triacylglycerol storage.
Mengxi Wang; Rachel J Roth Flach; Shinya U Amano; Myriam Aouadi; Anil Chawla; Michael P Czech
Identification of Map4k4 as a novel suppressor of skeletal muscle differentiation.

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All Publications

2013: Myriam Aouadi; Jessica L Cohen; Shinya U Amano; Sarah M C Nicoloro; Michaela Tencerova; Pranitha Vangala; Joseph C Yawe; Michael P Czech
Gene silencing in adipose tissue macrophages regulates whole-body metabolism in obese mice.
Proceedings of the National Academy of Sciences of the United States of America 2013;110(20):8278-83.
2013: Michael P Czech; D J Pedersen; M Tencerova; Myriam Aouadi
Insulin signalling mechanisms for triacylglycerol storage.
Diabetologia 2013;56(5):949-64.
2013: Mengxi Wang; Rachel J Roth Flach; Shinya U Amano; Myriam Aouadi; Anil Chawla; Michael P Czech
Identification of Map4k4 as a novel suppressor of skeletal muscle differentiation.
Molecular and cellular biology 2013;33(4):678-87.
2013: Rachel J Roth Flach; Thomas E Akie; Anouch Matevossian; Kimberly A Negrin; Marina T Paul; Michael P Czech
β3-Adrenergic receptor stimulation induces E-selectin-mediated adipose tissue inflammation.
The Journal of biological chemistry 2013;288(4):2882-92.
2012: Olga T Hardy; Michael P Czech; Silvia Corvera
What causes the insulin resistance underlying obesity?
Current opinion in endocrinology, diabetes, and obesity 2012;19(2):81-7.
2012: James L Young; Anna Cerny; Michael P Czech; Robert W Finberg; Evelyn A Kurt-Jones; Alfonso Mora; Bruce Woda; Silvia Corvera
CD14 deficiency impacts glucose homeostasis in mice through altered adrenal tone.
PloS one 2012;7(1):e29688.
2011: Timothy P Fitzgibbons; Greg M Hendricks; Sophia Kogan; Juerg Straubhaar; Myriam Aouadi; Michael P Czech
Similarity of mouse perivascular and brown adipose tissues and their resistance to diet-induced inflammation.
American journal of physiology. Heart and circulatory physiology 2011;301(4):H1425-37.
2011: Michael P Czech; Myriam Aouadi; Gregory J Tesz
RNAi-based therapeutic strategies for metabolic disease.
Nature reviews. Endocrinology 2011;7(8):473-84.
2011: Silvia Corvera; Michael P Czech
Tensions rise and blood flows over dysfunctional fat.
Circulation 2011;124(1):13-6.
2011: Gregory J Tesz; Myriam Aouadi; Matthieu Prot; Sarah M Nicoloro; Emilie Boutet; Shinya U Amano; Anca Goller; Mengxi Wang; Chang-An Guo; William E Salomon; Joseph V Virbasius; Rebecca A Baum; Mark J O'Connor; Ernesto Soto; Gary R Ostroff; Michael P Czech
Glucan particles for selective delivery of siRNA to phagocytic cells in mice.
The Biochemical journal 2011;436(2):351-62.
2011: Rajini Mudhasani; Vishwajeet Puri; Kathleen Hoover; Michael P Czech; Anthony N Imbalzano; Stephen N Jones
Dicer is required for the formation of white but not brown adipose tissue.
Journal of cellular physiology 2011;226(5):1399-406.
2011: Srijana Ranjit; Emilie Boutet; Pallavi Gandhi; Matthieu Prot; Yoshikazu Tamori; Anil Chawla; Andrew S Greenberg; Vishwajeet Puri; Michael P Czech
Regulation of fat specific protein 27 by isoproterenol and TNF-α to control lipolysis in murine adipocytes.
Journal of lipid research 2011;52(2):221-36.
2011: Olga Gealekman; Nina Guseva; Celia Hartigan; Sarah Apotheker; Matthew Gorgoglione; Kunal Gurav; Khan-Van Tran; Juerg Straubhaar; Sarah Nicoloro; Michael P Czech; Michael Thompson; Richard A Perugini; Silvia Corvera
Depot-specific differences and insufficient subcutaneous adipose tissue angiogenesis in human obesity.
Circulation 2011;123(2):186-94.
2011: Olga T Hardy; Richard A Perugini; Sarah M Nicoloro; Karen Gallagher-Dorval; Vishwajeet Puri; Juerg Straubhaar; Michael P Czech
Body mass index-independent inflammation in omental adipose tissue associated with insulin resistance in morbid obesity.
Surgery for obesity and related diseases : official journal of the American Society for Bariatric Surgery 2011;7(1):60-7.
2010: Jennifer L Christianson; Emilie Boutet; Vishwajeet Puri; Anil Chawla; Michael P Czech
Identification of the lipid droplet targeting domain of the Cidea protein.
Journal of lipid research 2010;51(12):3455-62.
2010: Qiong L Zhou; Zhen Y Jiang; Allan S Mabardy; Claudia M Del Campo; David G Lambright; John Holik; Kevin E Fogarty; Juerg Straubhaar; Sarah Nicoloro; Anil Chawla; Michael P Czech
A novel pleckstrin homology domain-containing protein enhances insulin-stimulated Akt phosphorylation and GLUT4 translocation in adipocytes.
The Journal of biological chemistry 2010;285(36):27581-9.
2010: Kalyani V P Guntur; Adilson Guilherme; Liting Xue; Anil Chawla; Michael P Czech
Map4k4 negatively regulates peroxisome proliferator-activated receptor (PPAR) gamma protein translation by suppressing the mammalian target of rapamycin (mTOR) signaling pathway in cultured adipocytes.
The Journal of biological chemistry 2010;285(9):6595-603.
2009: Adilson Guilherme; Gregory J Tesz; Kalyani V P Guntur; Michael P Czech
Tumor necrosis factor-alpha induces caspase-mediated cleavage of peroxisome proliferator-activated receptor gamma in adipocytes.
The Journal of biological chemistry 2009;284(25):17082-91.
2009: Myriam Aouadi; Gregory J Tesz; Sarah M C Nicoloro; Mengxi Wang; My Chouinard; Ernesto Soto; Gary R Ostroff; Michael P Czech
Orally delivered siRNA targeting macrophage Map4k4 suppresses systemic inflammation.
Nature 2009;458(7242):1180-4.
2009: Srivatsan Padmanabhan; Arnab Mukhopadhyay; Sri Devi Narasimhan; Gregory Tesz; Michael P Czech; Heidi A Tissenbaum
A PP2A regulatory subunit regulates C. elegans insulin/IGF-1 signaling by modulating AKT-1 phosphorylation.
Cell 2009;136(5):939-51.
2009: Kenneth D Bishop; John E Harris; John P Mordes; Dale L Greiner; Aldo A Rossini; Michael P Czech; Nancy E Phillips
Depletion of the programmed death-1 receptor completely reverses established clonal anergy in CD4(+) T lymphocytes via an interleukin-2-dependent mechanism.
Cellular immunology 2009;256(1-2):86-91.
2008: Xiarong Shi; Alison Burkart; Sarah M C Nicoloro; Michael P Czech; Juerg Straubhaar; Silvia Corvera
Paradoxical effect of mitochondrial respiratory chain impairment on insulin signaling and glucose transport in adipose cells.
The Journal of biological chemistry 2008;283(45):30658-67.
2008: Vishwajeet Puri; Michael P Czech
Lipid droplets: FSP27 knockout enhances their sizzle.
The Journal of clinical investigation 2008;118(8):2693-6.
2008: G Nana Hagan; Yenshou Lin; Mark Magnuson; Joseph Avruch; Michael P Czech
A Rictor-Myo1c complex participates in dynamic cortical actin events in 3T3-L1 adipocytes.
Molecular and cellular biology 2008;28(13):4215-26.
2008: Vishwajeet Puri; Srijana Ranjit; Silvana Konda; Sarah M C Nicoloro; Juerg Straubhaar; Anil Chawla; My Chouinard; Chenyi Lin; Alison Burkart; Silvia Corvera; Richard A Perugini; Michael P Czech
Cidea is associated with lipid droplets and insulin sensitivity in humans.
Proceedings of the National Academy of Sciences of the United States of America 2008;105(22):7833-8.
2008: Adilson Guilherme; Joseph V Virbasius; Vishwajeet Puri; Michael P Czech
Adipocyte dysfunctions linking obesity to insulin resistance and type 2 diabetes.
Nature reviews. Molecular cell biology 2008;9(5):367-77.
2008: Qiong L Zhou; Zhen Y Jiang; John Holik; Anil Chawla; G Nana Hagan; John Leszyk; Michael P Czech
Akt substrate TBC1D1 regulates GLUT1 expression through the mTOR pathway in 3T3-L1 adipocytes.
The Biochemical journal 2008;411(3):647-55.
2008: Jennifer L Christianson; Sarah M C Nicoloro; Juerg Straubhaar; Michael P Czech
Stearoyl-CoA desaturase 2 is required for peroxisome proliferator-activated receptor gamma expression and adipogenesis in cultured 3T3-L1 cells.
The Journal of biological chemistry 2008;283(5):2906-16.
2008: Vishwajeet Puri; Joseph V Virbasius; Adilson Guilherme; Michael P Czech
RNAi screens reveal novel metabolic regulators: RIP140, MAP4k4 and the lipid droplet associated fat specific protein (FSP) 27.
Acta physiologica (Oxford, England) 2008;192(1):103-15.
2007: Jonathan P DiNitto; Anna Delprato; Meng-Tse Gabe Lee; Thomas C Cronin; Shaohui Huang; Adilson Guilherme; Michael P Czech; David G Lambright
Structural basis and mechanism of autoregulation in 3-phosphoinositide-dependent Grp1 family Arf GTPase exchange factors.
Molecular cell 2007;28(4):569-83.
2007: Vishwajeet Puri; Silvana Konda; Srijana Ranjit; Myriam Aouadi; Anil Chawla; My Chouinard; Abhijit Chakladar; Michael P Czech
Fat-specific protein 27, a novel lipid droplet protein that enhances triglyceride storage.
The Journal of biological chemistry 2007;282(47):34213-8.
2007: Gregory J Tesz; Adilson Guilherme; Kalyani V P Guntur; Andrea C Hubbard; Xiaoqing Tang; Anil Chawla; Michael P Czech
Tumor necrosis factor alpha (TNFalpha) stimulates Map4k4 expression through TNFalpha receptor 1 signaling to c-Jun and activating transcription factor 2.
The Journal of biological chemistry 2007;282(27):19302-12.
2007: Shaohui Huang; Lawrence Lifshitz; Christine Jones; Karl D Bellve; Clive Standley; Sonya Fonseca; Silvia Corvera; Kevin E Fogarty; Michael P Czech
Insulin stimulates membrane fusion and GLUT4 accumulation in clathrin coats on adipocyte plasma membranes.
Molecular and cellular biology 2007;27(9):3456-69.
2007: Shaohui Huang; Michael P Czech
The GLUT4 glucose transporter.
Cell metabolism 2007;5(4):237-52.
2007: Vishwajeet Puri; Abhijit Chakladar; Joseph V Virbasius; Silvana Konda; Aimee M Powelka; My Chouinard; G Nana Hagan; Richard Perugini; Michael P Czech
RNAi-based gene silencing in primary mouse and human adipose tissues.
Journal of lipid research 2007;48(2):465-71.
2006: Michael P Czech
MicroRNAs as therapeutic targets.
The New England journal of medicine 2006;354(11):1194-5.
2006: Lijun Liu; Xi Song; Dandan He; Chandrasekhar Komma; Akiko Kita; Joseph V Virbasius; Guiqing Huang; Henry D Bellamy; Kunio Miki; Michael P Czech; G Wayne Zhou
Crystal structure of the C2 domain of class II phosphatidylinositide 3-kinase C2alpha.
The Journal of biological chemistry 2006;281(7):4254-60.
2006: Xiaoqing Tang; Adilson Guilherme; Abhijit Chakladar; Aimee M Powelka; Silvana Konda; Joseph V Virbasius; Sarah M C Nicoloro; Juerg Straubhaar; Michael P Czech
An RNA interference-based screen identifies MAP4K4/NIK as a negative regulator of PPARgamma, adipogenesis, and insulin-responsive hexose transport.
Proceedings of the National Academy of Sciences of the United States of America 2006;103(7):2087-92.
2006: Aimee M Powelka; Asha Seth; Joseph V Virbasius; Evangelos Kiskinis; Sarah M C Nicoloro; Adilson Guilherme; Xiaoqing Tang; Juerg Straubhaar; Andrew D Cherniack; Malcolm G Parker; Michael P Czech
Suppression of oxidative metabolism and mitochondrial biogenesis by the transcriptional corepressor RIP140 in mouse adipocytes.
The Journal of clinical investigation 2006;116(1):125-36.
2005: Avirup Bose; Adilson Guilherme; Shaohui Huang; Andrea C Hubbard; Charles R Lane; Neil A Soriano; Michael P Czech
The v-SNARE Vti1a regulates insulin-stimulated glucose transport and Acrp30 secretion in 3T3-L1 adipocytes.
The Journal of biological chemistry 2005;280(44):36946-51.
2005: Xiaoqing Tang; Aimee M Powelka; Neil A Soriano; Michael P Czech; Adilson Guilherme
PTEN, but not SHIP2, suppresses insulin signaling through the phosphatidylinositol 3-kinase/Akt pathway in 3T3-L1 adipocytes.
The Journal of biological chemistry 2005;280(23):22523-9.
2005: Zhen Y Jiang; Qiong L Zhou; John Holik; Shraddha Patel; John Leszyk; Kerri Coleman; My Chouinard; Michael P Czech
Identification of WNK1 as a substrate of Akt/protein kinase B and a negative regulator of insulin-stimulated mitogenesis in 3T3-L1 cells.
The Journal of biological chemistry 2005;280(22):21622-8.
2004: John E Harris; Kenneth D Bishop; Nancy E Phillips; John P Mordes; Dale L Greiner; Aldo A Rossini; Michael P Czech
Early growth response gene-2, a zinc-finger transcription factor, is required for full induction of clonal anergy in CD4+ T cells.
Journal of immunology (Baltimore, Md. : 1950) 2004;173(12):7331-8.
2004: Leanne Wilson-Fritch; Sarah M C Nicoloro; My Chouinard; Mitchell Lazar; Patricia C Chui; John Leszyk; Juerg Straubhaar; Michael P Czech; Silvia Corvera
Mitochondrial remodeling in adipose tissue associated with obesity and treatment with rosiglitazone.
The Journal of clinical investigation 2004;114(9):1281-9.
2004: Qiong L Zhou; Jin Gyoon Park; Zhen Y Jiang; John Holik; Partha Mitra; S Semiz; Adilson Guilherme; Aimee M Powelka; Xiaoqing Tang; Joseph V Virbasius; Michael P Czech
Analysis of insulin signalling by RNAi-based gene silencing.
Biochemical Society transactions 2004;32(Pt 5):817-21.
2004: Shaohui Huang; Lawrence Lifshitz; Varsha Patki-Kamath; Richard A Tuft; Kevin E Fogarty; Michael P Czech
Phosphatidylinositol-4,5-bisphosphate-rich plasma membrane patches organize active zones of endocytosis and ruffling in cultured adipocytes.
Molecular and cellular biology 2004;24(20):9102-23.
2004: Thomas C Cronin; Jonathan P DiNitto; Michael P Czech; David G Lambright
Structural determinants of phosphoinositide selectivity in splice variants of Grp1 family PH domains.
The EMBO journal 2004;23(19):3711-20.
2004: Adilson Guilherme; Neil A Soriano; Paul Furcinitti; Michael P Czech
Role of EHD1 and EHBP1 in perinuclear sorting and insulin-regulated GLUT4 recycling in 3T3-L1 adipocytes.
The Journal of biological chemistry 2004;279(38):40062-75.
2004: Partha Mitra; Xuexiu Zheng; Michael P Czech
RNAi-based analysis of CAP, Cbl, and CrkII function in the regulation of GLUT4 by insulin.
The Journal of biological chemistry 2004;279(36):37431-5.
2004: Anja Jaeschke; Michael P Czech; Roger J Davis
An essential role of the JIP1 scaffold protein for JNK activation in adipose tissue.
Genes & development 2004;18(16):1976-80.
2004: Avirup Bose; Stacey Robida; Paul Furcinitti; Anil Chawla; Kevin E Fogarty; Silvia Corvera; Michael P Czech
Unconventional myosin Myo1c promotes membrane fusion in a regulated exocytic pathway.
Molecular and cellular biology 2004;24(12):5447-58.
2004: Adilson Guilherme; Neil A Soriano; Sahana Bose; John Holik; Avirup Bose; Darcy P Pomerleau; Paul Furcinitti; John Leszyk; Silvia Corvera; Michael P Czech
EHD2 and the novel EH domain binding protein EHBP1 couple endocytosis to the actin cytoskeleton.
The Journal of biological chemistry 2004;279(11):10593-605.
2003: Michael P Czech
Insulin's expanding control of forkheads.
Proceedings of the National Academy of Sciences of the United States of America 2003;100(20):11198-200.
2003: Zhen Y Jiang; Qiong L Zhou; Kerri A Coleman; My Chouinard; Queta Boese; Michael P Czech
Insulin signaling through Akt/protein kinase B analyzed by small interfering RNA-mediated gene silencing.
Proceedings of the National Academy of Sciences of the United States of America 2003;100(13):7569-74.
2003: Sabina Semiz; Jin Gyoon Park; Sarah M C Nicoloro; Paul Furcinitti; Chuanyou Zhang; Anil Chawla; John Leszyk; Michael P Czech
Conventional kinesin KIF5B mediates insulin-stimulated GLUT4 movements on microtubules.
The EMBO journal 2003;22(10):2387-99.
2003: Leanne Wilson-Fritch; Alison Burkart; Gregory Bell; Karen Mendelson; John Leszyk; Sarah M C Nicoloro; Michael P Czech; Silvia Corvera
Mitochondrial biogenesis and remodeling during adipogenesis and in response to the insulin sensitizer rosiglitazone.
Molecular and cellular biology 2003;23(3):1085-94.
2003: Michael P Czech
Dynamics of phosphoinositides in membrane retrieval and insertion.
Annual review of physiology 2003;65():791-815.
2002: Avirup Bose; Adilson Guilherme; Stacey I Robida; Sarah M C Nicoloro; Qiong L Zhou; Zhen Y Jiang; Darcy P Pomerleau; Michael P Czech
Glucose transporter recycling in response to insulin is facilitated by myosin Myo1c.
Nature 2002;420(6917):821-4.
2002: Michael P Czech
Fat targets for insulin signaling.
Molecular cell 2002;9(4):695-6.
2002: Zhen Y Jiang; Anil Chawla; Avirup Bose; Michael Way; Michael P Czech
A phosphatidylinositol 3-kinase-independent insulin signaling pathway to N-WASP/Arp2/3/F-actin required for GLUT4 glucose transporter recycling.
The Journal of biological chemistry 2002;277(1):509-15.
2001: Jin Gyoon Park; Avirup Bose; John Leszyk; Michael P Czech
PYK2 as a mediator of endothelin-1/G alpha 11 signaling to GLUT4 glucose transporters.
The Journal of biological chemistry 2001;276(51):47751-4.
2001: Joseph V Virbasius; Xi Song; Darcy P Pomerleau; Yong Zhan; G Wayne Zhou; Michael P Czech
Activation of the Akt-related cytokine-independent survival kinase requires interaction of its phox domain with endosomal phosphatidylinositol 3-phosphate.
Proceedings of the National Academy of Sciences of the United States of America 2001;98(23):12908-13.
2001: Jes K Klarlund; John Holik; Anil Chawla; Jin Gyoon Park; JM Buxton; Michael P Czech
Signaling complexes of the FERM domain-containing protein GRSP1 bound to ARF exchange factor GRP1.
The Journal of biological chemistry 2001;276(43):40065-70.
2001: Avirup Bose; Andrew D Cherniack; SE Langille; Sarah M C Nicoloro; JM Buxton; Jin Gyoon Park; Anil Chawla; Michael P Czech
G(alpha)11 signaling through ARF6 regulates F-actin mobilization and GLUT4 glucose transporter translocation to the plasma membrane.
Molecular and cellular biology 2001;21(15):5262-75.
2001: Xi Song; W Xu; A Zhang; G Huang; X Liang; Joseph V Virbasius; Michael P Czech; G Wayne Zhou
Phox homology domains specifically bind phosphatidylinositol phosphates.
Biochemistry 2001;40(30):8940-4.
2001: M Emoto; SE Langille; Michael P Czech
A role for kinesin in insulin-stimulated GLUT4 glucose transporter translocation in 3T3-L1 adipocytes.
The Journal of biological chemistry 2001;276(14):10677-82.
2001: Jes K Klarlund; Michael P Czech
Isolation and properties of GRP1, an ADP-ribosylation factor (ARF)-guanine nucleotide exchange protein regulated by phosphatidylinositol 3,4,5-trisphosphate.
Methods in enzymology 2001;329():279-89.
2000: M Iwanishi; Michael P Czech; Andrew D Cherniack
The protein-tyrosine kinase fer associates with signaling complexes containing insulin receptor substrate-1 and phosphatidylinositol 3-kinase.
The Journal of biological chemistry 2000;275(50):38995-9000.
2000: Adilson Guilherme; M Emoto; JM Buxton; S Bose; R Sabini; William E Theurkauf; John Leszyk; Michael P Czech
Perinuclear localization and insulin responsiveness of GLUT4 requires cytoskeletal integrity in 3T3-L1 adipocytes.
The Journal of biological chemistry 2000;275(49):38151-9.
2000: Jes K Klarlund; W Tsiaras; John Holik; Anil Chawla; Michael P Czech
Distinct polyphosphoinositide binding selectivities for pleckstrin homology domains of GRP1-like proteins based on diglycine versus triglycine motifs.
The Journal of biological chemistry 2000;275(42):32816-21.
2000: S E Lietzke; S Bose; Thomas C Cronin; Jes K Klarlund; Anil Chawla; Michael P Czech; David G Lambright
Structural basis of 3-phosphoinositide recognition by pleckstrin homology domains.
Molecular cell 2000;6(2):385-94.
2000: M Emoto; Jes K Klarlund; S B Waters; V Hu; JM Buxton; Anil Chawla; Michael P Czech
A role for phospholipase D in GLUT4 glucose transporter translocation.
The Journal of biological chemistry 2000;275(10):7144-51.
1999: SE Langille; V Patki; Jes K Klarlund; JM Buxton; John Holik; Anil Chawla; Silvia Corvera; Michael P Czech
ADP-ribosylation factor 6 as a target of guanine nucleotide exchange factor GRP1.
The Journal of biological chemistry 1999;274(38):27099-104.
1999: B Fernández; Michael P Czech; H Meisner
Role of protein kinase C in signal attenuation following T cell receptor engagement.
The Journal of biological chemistry 1999;274(29):20244-50.
1999: Michael P Czech; Silvia Corvera
Signaling mechanisms that regulate glucose transport.
The Journal of biological chemistry 1999;274(4):1865-8.
1998: Adilson Guilherme; Michael P Czech
Stimulation of IRS-1-associated phosphatidylinositol 3-kinase and Akt/protein kinase B but not glucose transport by beta1-integrin signaling in rat adipocytes.
The Journal of biological chemistry 1998;273(50):33119-22.
1998: M Clodi; P Vollenweider; Jes K Klarlund; N Nakashima; Stuart S Martin; Michael P Czech; Jerrold M Olefsky
Effects of general receptor for phosphoinositides 1 on insulin and insulin-like growth factor I-induced cytoskeletal rearrangement, glucose transporter-4 translocation, and deoxyribonucleic acid synthesis.
Endocrinology 1998;139(12):4984-90.
1998: B VanRenterghem; M Morin; Michael P Czech; R A Heller-Harrison
Interaction of insulin receptor substrate-1 with the sigma3A subunit of the adaptor protein complex-3 in cultured adipocytes.
The Journal of biological chemistry 1998;273(45):29942-9.
1998: Silvia Corvera; Michael P Czech
Direct targets of phosphoinositide 3-kinase products in membrane traffic and signal transduction.
Trends in cell biology 1998;8(11):442-6.
1998: Adilson Guilherme; K Torres; Michael P Czech
Cross-talk between insulin receptor and integrin alpha5 beta1 signaling pathways.
The Journal of biological chemistry 1998;273(36):22899-903.
1998: M W Sleeman; N P Donegan; R Heller-Harrison; William Stratton Lane; Michael P Czech
Association of acyl-CoA synthetase-1 with GLUT4-containing vesicles.
The Journal of biological chemistry 1998;273(6):3132-5.
1998: Jes K Klarlund; Lucia E Rameh; Lewis C Cantley; JM Buxton; John Holik; C Sakelis; V Patki; Silvia Corvera; Michael P Czech
Regulation of GRP1-catalyzed ADP ribosylation factor guanine nucleotide exchange by phosphatidylinositol 3,4,5-trisphosphate.
The Journal of biological chemistry 1998;273(4):1859-62.
1997: Lucia E Rameh; Kermit L Carraway; A D Couvillon; G Rathbun; A Crompton; B VanRenterghem; Michael P Czech; Kodi S Ravichandran; Steven J Burakoff; D S Wang; C S Chen; A k Arvidsson; Lewis C Cantley
A comparative analysis of the phosphoinositide binding specificity of pleckstrin homology domains.
The Journal of biological chemistry 1997;272(35):22059-66.
1997: H Meisner; A Daga; JM Buxton; B Fernández; Anil Chawla; U Banerjee; Michael P Czech
Interactions of Drosophila Cbl with epidermal growth factor receptors and role of Cbl in R7 photoreceptor cell development.
Molecular and cellular biology 1997;17(4):2217-25.
1997: Jes K Klarlund; Adilson Guilherme; John Holik; Joseph V Virbasius; Anil Chawla; Michael P Czech
Signaling by phosphoinositide-3,4,5-trisphosphate through proteins containing pleckstrin and Sec7 homology domains.
Science (New York, N.Y.) 1997;275(5308):1927-30.
1996: Adilson Guilherme; Jes K Klarlund; G Krystal; Michael P Czech
Regulation of phosphatidylinositol 3,4,5-trisphosphate 5'-phosphatase activity by insulin.
The Journal of biological chemistry 1996;271(47):29533-6.
1996: Jes K Klarlund; A D Cherniack; M McMahon; Michael P Czech
Role of the Raf/mitogen-activated protein kinase pathway in p21ras desensitization.
The Journal of biological chemistry 1996;271(28):16674-7.
1996: Joseph V Virbasius; Adilson Guilherme; Michael P Czech
Mouse p170 is a novel phosphatidylinositol 3-kinase containing a C2 domain.
The Journal of biological chemistry 1996;271(23):13304-7.
1996: R A Heller-Harrison; M Morin; A Guilherme; Michael P Czech
Insulin-mediated targeting of phosphatidylinositol 3-kinase to GLUT4-containing vesicles.
The Journal of biological chemistry 1996;271(17):10200-4.
1996: K Baltensperger; V Karoor; H Paul; A Ruoho; Michael P Czech; C C Malbon
The beta-adrenergic receptor is a substrate for the insulin receptor tyrosine kinase.
The Journal of biological chemistry 1996;271(2):1061-4.
1995: H Meisner; Michael P Czech
Coupling of the proto-oncogene product c-Cbl to the epidermal growth factor receptor.
The Journal of biological chemistry 1995;270(43):25332-5.
1995: R A Heller-Harrison; M Morin; Michael P Czech
Insulin regulation of membrane-associated insulin receptor substrate 1.
The Journal of biological chemistry 1995;270(41):24442-50.
1995: Jes K Klarlund; A D Cherniack; Michael P Czech
Divergent mechanisms for homologous desensitization of p21ras by insulin and growth factors.
The Journal of biological chemistry 1995;270(40):23421-8.
1995: Assia Shisheva; Stephen J Doxsey; JM Buxton; Michael P Czech
Pericentriolar targeting of GDP-dissociation inhibitor isoform 2.
European journal of cell biology 1995;68(2):143-58.
1995: H Meisner; Michael P Czech
A 115 kDa tyrosine phosphorylated protein associates with Grb-2 in activated Jurkat cells.
Annals of the New York Academy of Sciences 1995;766():204-5.
1995: L McCollam; L Bonfini; C A Karlovich; B R Conway; L M Kozma; Utpal Banerjee; Michael P Czech
Functional roles for the pleckstrin and Dbl homology regions in the Ras exchange factor Son-of-sevenless.
The Journal of biological chemistry 1995;270(27):15954-7.
1995: H Meisner; B R Conway; D Hartley; Michael P Czech
Interactions of Cbl with Grb2 and phosphatidylinositol 3'-kinase in activated Jurkat cells.
Molecular and cellular biology 1995;15(7):3571-8.
1995: C A Karlovich; L Bonfini; L McCollam; R D Rogge; A Daga; Michael P Czech; Utpal Banerjee
In vivo functional analysis of the Ras exchange factor son of sevenless.
Science (New York, N.Y.) 1995;268(5210):576-9.
1995: A D Cherniack; Jes K Klarlund; B R Conway; Michael P Czech
Disassembly of Son-of-sevenless proteins from Grb2 during p21ras desensitization by insulin.
The Journal of biological chemistry 1995;270(4):1485-8.
1995: Michael P Czech
Molecular actions of insulin on glucose transport.
Annual review of nutrition 1995;15():441-71.
1994: K Baltensperger; L M Kozma; S R Jaspers; Michael P Czech
Regulation by insulin of phosphatidylinositol 3'-kinase bound to alpha- and beta-isoforms of p85 regulatory subunit.
The Journal of biological chemistry 1994;269(46):28937-46.
1994: Assia Shisheva; JM Buxton; Michael P Czech
Differential intracellular localizations of GDP dissociation inhibitor isoforms. Insulin-dependent redistribution of GDP dissociation inhibitor-2 in 3T3-L1 adipocytes.
The Journal of biological chemistry 1994;269(39):23865-8.
1994: Silvia Corvera; Anil Chawla; R Chakrabarti; M Joly; JM Buxton; Michael P Czech
A double leucine within the GLUT4 glucose transporter COOH-terminal domain functions as an endocytosis signal.
The Journal of cell biology 1994;126(6):1625.
1994: Silvia Corvera; Anil Chawla; R Chakrabarti; M Joly; JM Buxton; Michael P Czech
A double leucine within the GLUT4 glucose transporter COOH-terminal domain functions as an endocytosis signal.
The Journal of cell biology 1994;126(4):979-89.
1994: Assia Shisheva; T C Südhof; Michael P Czech
Cloning, characterization, and expression of a novel GDP dissociation inhibitor isoform from skeletal muscle.
Molecular and cellular biology 1994;14(5):3459-68.
1994: A D Cherniack; Jes K Klarlund; Michael P Czech
Phosphorylation of the Ras nucleotide exchange factor son of sevenless by mitogen-activated protein kinase.
The Journal of biological chemistry 1994;269(7):4717-20.
1993: Michael P Czech; Anil Chawla; C W Woon; JM Buxton; Michal Armoni; W Tang; M Joly; Silvia Corvera
Exofacial epitope-tagged glucose transporter chimeras reveal COOH-terminal sequences governing cellular localization.
The Journal of cell biology 1993;123(1):127-35.
1993: K Baltensperger; L M Kozma; A D Cherniack; Jes K Klarlund; Anil Chawla; Utpal Banerjee; Michael P Czech
Binding of the Ras activator son of sevenless to insulin receptor substrate-1 signaling complexes.
Science (New York, N.Y.) 1993;260(5116):1950-2.
1993: L Kozma; K Baltensperger; Jes K Klarlund; A Porras; E Santos; Michael P Czech
The ras signaling pathway mimics insulin action on glucose transporter translocation.
Proceedings of the National Academy of Sciences of the United States of America 1993;90(10):4460-4.
1993: Michael P Czech; JM Buxton
Insulin action on the internalization of the GLUT4 glucose transporter in isolated rat adipocytes.
The Journal of biological chemistry 1993;268(13):9187-90.
1993: Jes K Klarlund; N Khalaf; L Kozma; Michael P Czech
Activation of protein kinases by insulin and non-hydrolyzable GTP analogs in permeabilized 3T3-L1 adipocytes.
The Journal of biological chemistry 1993;268(11):7646-9.
1992: Li Li; J Zhou; G James; R Heller-Harrison; Michael P Czech; E N Olson
FGF inactivates myogenic helix-loop-helix proteins through phosphorylation of a conserved protein kinase C site in their DNA-binding domains.
Cell 1992;71(7):1181-94.
1992: Li Li; R Heller-Harrison; Michael P Czech; E N Olson
Cyclic AMP-dependent protein kinase inhibits the activity of myogenic helix-loop-helix proteins.
Molecular and cellular biology 1992;12(10):4478-85.
1992: K Baltensperger; R E Lewis; C W Woon; P Vissavajjhala; A H Ross; Michael P Czech
Catalysis of serine and tyrosine autophosphorylation by the human insulin receptor.
Proceedings of the National Academy of Sciences of the United States of America 1992;89(17):7885-9.
1992: L Wolfe; A P Bradford; Jes K Klarlund; Michael P Czech
Purification and characterization of a cytosolic insulin-stimulated serine kinase from rat liver.
The Journal of biological chemistry 1992;267(14):9749-56.
1992: Michael P Czech; B M Clancy; A Pessino; C W Woon; S A Harrison
Complex regulation of simple sugar transport in insulin-responsive cells.
Trends in biochemical sciences 1992;17(5):197-201.
1992: S A Harrison; B M Clancy; A Pessino; Michael P Czech
Activation of cell surface glucose transporters measured by photoaffinity labeling of insulin-sensitive 3T3-L1 adipocytes.
The Journal of biological chemistry 1992;267(6):3783-8.
1991: A Pessino; D N Hebert; C W Woon; S A Harrison; B M Clancy; JM Buxton; Anthony Carruthers; Michael P Czech
Evidence that functional erythrocyte-type glucose transporters are oligomers.
The Journal of biological chemistry 1991;266(30):20213-7.
1991: S A Harrison; JM Buxton; B M Clancy; Michael P Czech
Evidence that erythroid-type glucose transporter intrinsic activity is modulated by cadmium treatment of mouse 3T3-L1 cells.
The Journal of biological chemistry 1991;266(29):19438-49.
1991: S A Harrison; JM Buxton; Michael P Czech
Suppressed intrinsic catalytic activity of GLUT1 glucose transporters in insulin-sensitive 3T3-L1 adipocytes.
Proceedings of the National Academy of Sciences of the United States of America 1991;88(17):7839-43.
1991: R A Heller-Harrison; Michael P Czech
Enhanced casein kinase II activity in COS-1 cells upon overexpression of either its catalytic or noncatalytic subunit.
The Journal of biological chemistry 1991;266(22):14435-9.
1991: K B Clairmont; Michael P Czech
Extracellular release as the major degradative pathway of the insulin-like growth factor II/mannose 6-phosphate receptor.
The Journal of biological chemistry 1991;266(19):12131-4.
1991: B M Clancy; S A Harrison; JM Buxton; Michael P Czech
Protein synthesis inhibitors activate glucose transport without increasing plasma membrane glucose transporters in 3T3-L1 adipocytes.
The Journal of biological chemistry 1991;266(16):10122-30.
1991: H Meisner; Michael P Czech
Phosphorylation of transcriptional factors and cell-cycle-dependent proteins by casein kinase II.
Current opinion in cell biology 1991;3(3):474-83.
1991: Jes K Klarlund; S R Jaspers; N Khalaf; A P Bradford; T B Miller; Michael P Czech
An insulin-stimulated kemptide kinase purified from rat liver is deactivated by phosphatase 2A.
The Journal of biological chemistry 1991;266(7):4052-5.
1990: S A Harrison; JM Buxton; B M Clancy; Michael P Czech
Insulin regulation of hexose transport in mouse 3T3-L1 cells expressing the human HepG2 glucose transporter.
The Journal of biological chemistry 1990;265(33):20106-16.
1990: K B Clairmont; Michael P Czech
Insulin injection increases the levels of serum receptors for transferrin and insulin-like growth factor-II/mannose-6-phosphate in intact rats.
Endocrinology 1990;127(4):1568-73.
1990: B M Clancy; Michael P Czech
Hexose transport stimulation and membrane redistribution of glucose transporter isoforms in response to cholera toxin, dibutyryl cyclic AMP, and insulin in 3T3-L1 adipocytes.
The Journal of biological chemistry 1990;265(21):12434-43.
1990: K T Yu; W B Benjamin; S Ramakrishna; N Khalaf; Michael P Czech
An insulin-sensitive cytosolic protein kinase accounts for the regulation of ATP citrate-lyase phosphorylation.
The Biochemical journal 1990;268(3):539-45.
1990: S A Harrison; JM Buxton; A L Helgerson; R G MacDonald; F J Chlapowski; Anthony Carruthers; Michael P Czech
Insulin action on activity and cell surface disposition of human HepG2 glucose transporters expressed in Chinese hamster ovary cells.
The Journal of biological chemistry 1990;265(10):5793-801.
1990: R E Lewis; L Cao; D Perregaux; Michael P Czech
Threonine 1336 of the human insulin receptor is a major target for phosphorylation by protein kinase C.
Biochemistry 1990;29(7):1807-13.
1990: R E Lewis; G P Wu; R G MacDonald; Michael P Czech
Insulin-sensitive phosphorylation of serine 1293/1294 on the human insulin receptor by a tightly associated serine kinase.
The Journal of biological chemistry 1990;265(2):947-54.
1990: Jes K Klarlund; A P Bradford; M G Milla; Michael P Czech
Purification of a novel insulin-stimulated protein kinase from rat liver.
The Journal of biological chemistry 1990;265(1):227-34.
1989: R A Heller-Harrison; H Meisner; Michael P Czech
Cloning and characterization of a cDNA encoding the beta subunit of human casein kinase II.
Biochemistry 1989;28(23):9053-8.
1989: Michael P Czech
Signal transmission by the insulin-like growth factors.
Cell 1989;59(2):235-8.
1989: K B Clairmont; Michael P Czech
Chicken and Xenopus mannose 6-phosphate receptors fail to bind insulin-like growth factor II.
The Journal of biological chemistry 1989;264(28):16390-2.
1989: H Meisner; R Heller-Harrison; J Buxton; Michael P Czech
Molecular cloning of the human casein kinase II alpha subunit.
Biochemistry 1989;28(9):4072-6.
1989: R G MacDonald; Mark Tepper; K B Clairmont; S B Perregaux; Michael P Czech
Serum form of the rat insulin-like growth factor II/mannose 6-phosphate receptor is truncated in the carboxyl-terminal domain.
The Journal of biological chemistry 1989;264(6):3256-61.
1989: Michael P Czech; R E Lewis; S Corvera
Multifunctional glycoprotein receptors for insulin and the insulin-like growth factors.
Ciba Foundation symposium 1989;145():27-41; discussion 42-4.
1988: Jes K Klarlund; Michael P Czech
Insulin-like growth factor I and insulin rapidly increase casein kinase II activity in BALB/c 3T3 fibroblasts.
The Journal of biological chemistry 1988;263(31):15872-5.
1988: Silvia Corvera; K Folander; K B Clairmont; Michael P Czech
A highly phosphorylated subpopulation of insulin-like growth factor II/mannose 6-phosphate receptors is concentrated in a clathrin-enriched plasma membrane fraction.
Proceedings of the National Academy of Sciences of the United States of America 1988;85(20):7567-71.
1988: Michael P Czech; Jes K Klarlund; K A Yagaloff; A P Bradford; R E Lewis
Insulin receptor signaling. Activation of multiple serine kinases.
The Journal of biological chemistry 1988;263(23):11017-20.
1988: Silvia Corvera; P J Roach; A A DePaoli-Roach; Michael P Czech
Insulin action inhibits insulin-like growth factor-II (IGF-II) receptor phosphorylation in H-35 hepatoma cells. IGF-II receptors isolated from insulin-treated cells exhibit enhanced in vitro phosphorylation by casein kinase II.
The Journal of biological chemistry 1988;263(7):3116-22.
1988: R G MacDonald; S R Pfeffer; L Coussens; Mark Tepper; C M Brocklebank; J E Mole; J K Anderson; E Chen; Michael P Czech; A Ullrich
A single receptor binds both insulin-like growth factor II and mannose-6-phosphate.
Science (New York, N.Y.) 1988;239(4844):1134-7.
1988: S Corvera; K A Yagaloff; R E Whitehead; Michael P Czech
Tyrosine phosphorylation of the receptor for insulin-like growth factor II is inhibited in plasma membranes from insulin-treated rat adipocytes.
The Biochemical journal 1988;250(1):47-52.
1987: R E Lewis; Michael P Czech
Phospholipid environment alters hormone-sensitivity of the purified insulin receptor kinase.
The Biochemical journal 1987;248(3):829-36.
1987: K T Yu; N Khalaf; Michael P Czech
Insulin stimulates a novel Mn2+-dependent cytosolic serine kinase in rat adipocytes.
The Journal of biological chemistry 1987;262(34):16677-85.
1987: Roger J Davis; M Faucher; L K Racaniello; Anthony Carruthers; Michael P Czech
Insulin-like growth factor I and epidermal growth factor regulate the expression of transferrin receptors at the cell surface by distinct mechanisms.
The Journal of biological chemistry 1987;262(27):13126-34.
1987: K T Yu; N Khalaf; Michael P Czech
Insulin stimulates the tyrosine phosphorylation of a Mr = 160,000 glycoprotein in rat adipocyte plasma membranes.
The Journal of biological chemistry 1987;262(16):7865-73.
1987: K T Yu; N Khalaf; Michael P Czech
Insulin stimulates a membrane-bound serine kinase that may be phosphorylated on tyrosine.
Proceedings of the National Academy of Sciences of the United States of America 1987;84(12):3972-6.
1987: K T Yu; Michael P Czech
Mechanism of signaling by insulin receptor kinase.
Progress in clinical and biological research 1987;249():99-112.
1986: C Mottola; R G MacDonald; J L Brackett; J E Mole; J K Anderson; Michael P Czech
Purification and amino-terminal sequence of an insulin-like growth factor-binding protein secreted by rat liver BRL-3A cells.
The Journal of biological chemistry 1986;261(24):11180-8.
1986: R J Davis; Gary L Johnson; D J Kelleher; J K Anderson; J E Mole; Michael P Czech
Identification of serine 24 as the unique site on the transferrin receptor phosphorylated by protein kinase C.
The Journal of biological chemistry 1986;261(19):9034-41.
1986: S Corvera; R E Whitehead; C Mottola; Michael P Czech
The insulin-like growth factor II receptor is phosphorylated by a tyrosine kinase in adipocyte plasma membranes.
The Journal of biological chemistry 1986;261(17):7675-9.
1985: Michael P Czech; K T Yu; R E Lewis; R J Davis; C Mottola; R G MacDonald; P C Necessary; S Corvera
Insulin receptor kinase and its mode of signaling membrane components.
Diabetes/metabolism reviews 1985;1(1-2):33-58.