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Jochen Dahm-Daphi

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Moritz Birkelbach; Jochen Dahm-Daphi; Benedict Daly; Michael I Ebright; Natalie Ferraiolo; Liliana Gheorghiu; Lisa A Kachnic; Carl O'Hara; Heike N Pfäffle; Lecia V Sequist; Cheryl Spencer; Johnathan R Whetstine; Cyril H Benes; Lee Zou; Henning Willers
Detection of impaired homologous recombination repair in NSCLC cells and tissues.
T Rieckmann; Gabor Rohaly; Ekkehard Dikomey; Irena Dornreiter; K Hoffer; S Kocher; M Kriegs; L Nitsch; C Petersen; Jochen Dahm-Daphi
p53 modulates homologous recombination at I-SceI-induced double-strand breaks through cell-cycle regulation.
Wael Y Mansour; Cordula Petersen; Thorsten Rieckmann; Michael Baumann; Natalia V Bogdanova; Kerstin Borgmann; Ekkehard Dikomey; Thilo Dörk; Richard A Gatti; Hailiang Hu; Ulla Kasten-Pisula; Sabrina Köcher; Mechtild Krause; Jochen Dahm-Daphi
Aberrant overexpression of miR-421 downregulates ATM and leads to a pronounced DSB repair defect and clinical hypersensitivity in SKX squamous cell carcinoma.

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All Publications

2013: Moritz Birkelbach; Jochen Dahm-Daphi; Benedict Daly; Michael I Ebright; Natalie Ferraiolo; Liliana Gheorghiu; Lisa A Kachnic; Carl O'Hara; Heike N Pfäffle; Lecia V Sequist; Cheryl Spencer; Johnathan R Whetstine; Cyril H Benes; Lee Zou; Henning Willers
Detection of impaired homologous recombination repair in NSCLC cells and tissues.
Journal of thoracic oncology : official publication of the International Association for the Study of Lung Cancer 2013;8(3):279-86.
2013: T Rieckmann; Gabor Rohaly; Ekkehard Dikomey; Irena Dornreiter; K Hoffer; S Kocher; M Kriegs; L Nitsch; C Petersen; Jochen Dahm-Daphi
p53 modulates homologous recombination at I-SceI-induced double-strand breaks through cell-cycle regulation.
Oncogene 2013;32(8):968-75.
2013: Wael Y Mansour; Cordula Petersen; Thorsten Rieckmann; Michael Baumann; Natalia V Bogdanova; Kerstin Borgmann; Ekkehard Dikomey; Thilo Dörk; Richard A Gatti; Hailiang Hu; Ulla Kasten-Pisula; Sabrina Köcher; Mechtild Krause; Jochen Dahm-Daphi
Aberrant overexpression of miR-421 downregulates ATM and leads to a pronounced DSB repair defect and clinical hypersensitivity in SKX squamous cell carcinoma.
Radiotherapy and oncology : journal of the European Society for Therapeutic Radiology and Oncology 2013;106(1):147-54.
2012: Annabelle E Fenske; Stephanie Glaesener; Friedemann Honecker; Juergen Thomale; Carsten Bokemeyer; Jochen Dahm-Daphi; Dorothee C Dartsch
Cisplatin resistance induced in germ cell tumour cells is due to reduced susceptibility towards cell death but not to altered DNA damage induction or repair.
Cancer letters 2012;324(2):171-8.
2012: E Dikomey; Jochen Dahm-Daphi; L Distel
[Prediction of the reaction of normal tissue and tumor cells to radiotherapy].
Strahlentherapie und Onkologie : Organ der Deutschen Röntgengesellschaft ... [et al] 2012;188 Suppl 3():304-7.
2012: Sabrina Köcher; Wael Y Mansour; Thorsten Rieckmann; Gabor Rohaly; Ekkehard Dikomey; Irena Dornreiter; Jochen Dahm-Daphi
Radiation-induced double-strand breaks require ATM but not Artemis for homologous recombination during S-phase.
Nucleic acids research 2012;40(17):8336-47.
2011: Meng Wang; Michael Baumann; Cyril Benes; Jochen Dahm-Daphi; Ekkehard Dikomey; Liliana Gheorghiu; Mechthild Krause; Malte Kriegs; Fabian Morsbach; Akash Nanda; David Sander; Jeffrey Settleman; Henning Willers
EGF receptor inhibition radiosensitizes NSCLC cells by inducing senescence in cells sustaining DNA double-strand breaks.
Cancer research 2011;71(19):6261-9.
2011: Laura Myllynen; Cordula Petersen; Thorsten Rieckmann; Jochen Dahm-Daphi; Ekkehard Dikomey; Ulla Kasten-Pisula; Malte Kriegs
In tumor cells regulation of DNA double strand break repair through EGF receptor involves both NHEJ and HR and is independent of p53 and K-Ras status.
Radiotherapy and oncology : journal of the European Society for Therapeutic Radiology and Oncology 2011;101(1):147-51.
2011: Lisa A Kachnic; Li Li; Loreen Fournier; Natalie Ferraiolo; Jochen Dahm-Daphi; Kerstin Borgmann; Henning Willers
FANCD2 but not FANCA promotes cellular resistance to type II topoisomerase poisons.
Cancer letters 2011;305(1):86-93.
2011: Lilach Moyal; Yaniv lerenthal; Mali Gana-Weisz; Gilad Mass; Sairei So; Shih-Ya Wang; Berina Eppink; Young Min Chung; Gil Shalev; Efrat Shema; Dganit Shkedy; Nechama I Smorodinsky; Nicole van Vliet; Bernhard Kuster; Matthias Mann; Aaron Ciechanover; Jochen Dahm-Daphi; Roland Kanaar; Mickey C-T Hu; David J Chen; Moshe Oren; Yosef Shiloh
Requirement of ATM-dependent monoubiquitylation of histone H2B for timely repair of DNA double-strand breaks.
Molecular cell 2011;41(5):529-42.
2011: Bianca M Sirbu; Verena Wülfing; Lee Zou; Katie E Clarkson; Jochen Dahm-Daphi; Liliana Gheorghiu; Sarah J Lachmayer; Linda W Lee; Lara M Marten; Simon Nicholas Powell; Henning Willers
ATR-p53 restricts homologous recombination in response to replicative stress but does not limit DNA interstrand crosslink repair in lung cancer cells.
PloS one 2011;6(8):e23053.
2010: Wael Y Mansour; Tim Rhein; Jochen Dahm-Daphi
The alternative end-joining pathway for repair of DNA double-strand breaks requires PARP1 but is not dependent upon microhomologies.
Nucleic acids research 2010;38(18):6065-77.
2010: Malte Kriegs; Ulla Kasten-Pisula; Thorsten Rieckmann; Katharina Holst; Jarob Saker; Jochen Dahm-Daphi; Ekkehard Dikomey
The epidermal growth factor receptor modulates DNA double-strand break repair by regulating non-homologous end-joining.
DNA repair 2010;9(8):889-97.
2010: Rafaat El-Awady; Ekram M Y Saleh; Jochen Dahm-Daphi
Targeting DNA double-strand break repair: is it the right way for sensitizing cells to 5-fluorouracil?
Anti-cancer drugs 2010;21(3):277-87.
2009: Ulla Kasten-Pisula; Apostolos Menegakis; Ingo Brammer; Kerstin Borgmann; Wael Y Mansour; Sarah Degenhardt; Mechthild Krause; Andreas Schreiber; Jochen Dahm-Daphi; Cordula Petersen; Ekkehard Dikomey; Michael Baumann
The extreme radiosensitivity of the squamous cell carcinoma SKX is due to a defect in double-strand break repair.
Radiotherapy and oncology : journal of the European Society for Therapeutic Radiology and Oncology 2009;90(2):257-64.
2008: Wael Y Mansour; Sabine Schumacher; Raphael Rosskopf; Tim Rhein; Filip Schmidt-Petersen; Fruszina Gatzemeier; Friedrich Haag; Kerstin Borgmann; Henning Willers; Jochen Dahm-Daphi
Hierarchy of nonhomologous end-joining, single-strand annealing and gene conversion at site-directed DNA double-strand breaks.
Nucleic acids research 2008;36(12):4088-98.
2008: Leonie Schulte-Uentrop; Raafat A El-Awady; Lena Schliecker; Henning Willers; Jochen Dahm-Daphi
Distinct roles of XRCC4 and Ku80 in non-homologous end-joining of endonuclease- and ionizing radiation-induced DNA double-strand breaks.
Nucleic acids research 2008;36(8):2561-9.
2008: Dirk Rades; Guenther Bohlen; Jürgen Dunst; Radka Lohynska; Theo Veninga; Lukas J A Stalpers; Steven E Schild; Jochen Dahm-Daphi
Comparison of short-course versus long-course whole-brain radiotherapy in the treatment of brain metastases.
Strahlentherapie und Onkologie : Organ der Deutschen Röntgengesellschaft ... [et al] 2008;184(1):30-5.
2007: Jochen Dahm-Daphi; Lisa Wiesmüller; Ekkehard Dikomey
"Meeting Report DNA Repair 2006: Ninth Biennial Meeting of the German Society for Research on DNA Repair" [DNA Repair 6 (2007) 140-144].
DNA repair 2007;6(6):877-82.
2007: Ulla Kasten-Pisula; Sabine Windhorst; Jochen Dahm-Daphi; Georg W Mayr; Ekkehard Dikomey
Radiosensitization of tumour cell lines by the polyphenol Gossypol results from depressed double-strand break repair and not from enhanced apoptosis.
Radiotherapy and oncology : journal of the European Society for Therapeutic Radiology and Oncology 2007;83(3):296-303.
2007: Jochen Dahm-Daphi; Lisa Wiesm ller; Ekkehard Dikomey
DNA Repair 2006: ninth biennial meeting of the German Society for Research on DNA repair.
DNA repair 2007;6(1):140-4.
2006: Dirk Rades; Jochen Dahm-Daphi; Volker Rudat; Rainer Schulte; Lukas J A Stalpers; Theo Veninga; Peter J Hoskin
Is short-course radiotherapy with high doses per fraction the appropriate regimen for metastatic spinal cord compression in colorectal cancer patients?
Strahlentherapie und Onkologie : Organ der Deutschen Röntgengesellschaft ... [et al] 2006;182(12):708-12.
2006: Henning Willers; J Husson; L W Lee; Petra Hubbe; F Gazemeier; Simon Nicholas Powell; Jochen Dahm-Daphi
Distinct mechanisms of nonhomologous end joining in the repair of site-directed chromosomal breaks with noncomplementary and complementary ends.
Radiation research 2006;166(4):567-74.
2006: Dirk Rades; Peter J Hoskin; Lukas J A Stalpers; Rainer Schulte; Philip Poortmans; Theo Veninga; Jochen Dahm-Daphi; Nermina Obralic; Ingeborg Wildfang; Roja Bahrehmand; Rita Engenhart-Cabilic; Steven E Schild
Short-course radiotherapy is not optimal for spinal cord compression due to myeloma.
International journal of radiation oncology, biology, physics 2006;64(5):1452-7.
2005: Rafaat El-Awady; M Mahmoud; Ekram M Y Saleh; H Abd El-Baky; M Lotayef; Jochen Dahm-Daphi; Ekkehard Dikomey
No correlation between radiosensitivity or double-strand break repair capacity of normal fibroblasts and acute normal tissue reaction after radiotherapy of breast cancer patients.
International journal of radiation biology 2005;81(7):501-8.
2005: Jochen Dahm-Daphi; Petra Hubbe; Fruzsina Horvath; Rafaat El-Awady; Katie E Bouffard; Simon Nicholas Powell; Henning Willers
Nonhomologous end-joining of site-specific but not of radiation-induced DNA double-strand breaks is reduced in the presence of wild-type p53.
Oncogene 2005;24(10):1663-72.
2004: Henning Willers; Jochen Dahm-Daphi; Simon Nicholas Powell
Repair of radiation damage to DNA.
British journal of cancer 2004;90(7):1297-301.
2004: A Böhnke; F Westphal; A Schmidt; Rafaat El-Awady; Jochen Dahm-Daphi
Role of p53 mutations, protein function and DNA damage for the radiosensitivity of human tumour cells.
International journal of radiation biology 2004;80(1):53-63.
2003: Rafaat El-Awady; Ekkehard Dikomey; Jochen Dahm-Daphi
Radiosensitivity of human tumour cells is correlated with the induction but not with the repair of DNA double-strand breaks.
British journal of cancer 2003;89(3):593-601.
2002: Kerstin Borgmann; Barbara Röper; Rafaat El-Awady; Sophie Brackrock; Maika Bigalke; Tilo Dörk; Winfried Alberti; Ekkehard Dikomey; Jochen Dahm-Daphi
Indicators of late normal tissue response after radiotherapy for head and neck cancer: fibroblasts, lymphocytes, genetics, DNA repair, and chromosome aberrations.
Radiotherapy and oncology : journal of the European Society for Therapeutic Radiology and Oncology 2002;64(2):141-52.
2001: Henning Willers; EE McCarthy; Petra Hubbe; Jochen Dahm-Daphi; Simon Nicholas Powell
Homologous recombination in extrachromosomal plasmid substrates is not suppressed by p53.
Carcinogenesis 2001;22(11):1757-63.
2001: Rafaat El-Awady; Ekkehard Dikomey; Jochen Dahm-Daphi
Heat effects on DNA repair after ionising radiation: hyperthermia commonly increases the number of non-repaired double-strand breaks and structural rearrangements.
Nucleic acids research 2001;29(9):1960-6.
2000: Henning Willers; EE McCarthy; Winfried Alberti; Jochen Dahm-Daphi; Simon Nicholas Powell
Loss of wild-type p53 function is responsible for upregulated homologous recombination in immortal rodent fibroblasts.
International journal of radiation biology 2000;76(8):1055-62.
2000: Jochen Dahm-Daphi
p53: biology and role for cellular radiosensitivity.
Strahlentherapie und Onkologie : Organ der Deutschen Röntgengesellschaft ... [et al] 2000;176(6):278-85.
2000: Jochen Dahm-Daphi; C Sass; Winfried Alberti
Comparison of biological effects of DNA damage induced by ionizing radiation and hydrogen peroxide in CHO cells.
International journal of radiation biology 2000;76(1):67-75.
1998: Jochen Dahm-Daphi; Ekkehard Dikomey; Ingo Brammer
DNA-repair, cell killing and normal tissue damage.
Strahlentherapie und Onkologie : Organ der Deutschen Röntgengesellschaft ... [et al] 1998;174 Suppl 3():8-11.
1998: Ekkehard Dikomey; Jochen Dahm-Daphi; Ingo Brammer; R Martensen; B Kaina
Correlation between cellular radiosensitivity and non-repaired double-strand breaks studied in nine mammalian cell lines.
International journal of radiation biology 1998;73(3):269-78.
1997: Jochen Dahm-Daphi; Ingo Brammer; Ekkehard Dikomey
Heat effects on the repair of DNA double-strand breaks in CHO cells.
International journal of radiation biology 1997;72(2):171-9.
1996: Jochen Dahm-Daphi; Ekkehard Dikomey
Rejoining of DNA double-strand breaks in X-irradiated CHO cells studied by constant- and graded-field gel electrophoresis.
International journal of radiation biology 1996;69(5):615-21.
1995: A Chukhlovin; Jochen Dahm-Daphi; G Gercken; A R Zander; Ekkehard Dikomey
Comparative studies of induction and repair of DNA double-strand breaks in X-irradiated alveolar macrophages and resting peripheral blood lymphocytes using constant-field gel electrophoresis.
International journal of radiation biology 1995;68(2):163-8.
1995: Ekkehard Dikomey; M Flentje; Jochen Dahm-Daphi
Comparison between the alkaline unwinding technique and neutral filter elution using CHO, V79 and EAT cells.
International journal of radiation biology 1995;67(3):269-75.
1995: Jochen Dahm-Daphi; Ekkehard Dikomey
Separation of DNA fragments induced by ionizing irradiation using a graded-field gel electrophoresis.
International journal of radiation biology 1995;67(2):161-8.
1994: Jochen Dahm-Daphi; Ekkehard Dikomey
Non-reparable DNA strand breaks and cell killing studied in CHO cells after X-irradiation at different passage numbers.
International journal of radiation biology 1994;66(5):553-5.
1994: Jochen Dahm-Daphi; Ekkehard Dikomey; C Pyttlik
Relationship between non-reparable DNA strand breaks and cell survival studied in X-irradiated CHO, CHO K1, xrs1 and xrs5 cells.
International journal of radiation biology 1994;65(6):657-63.
1994: Ekkehard Dikomey; Jochen Dahm-Daphi
Workshop report: Techniques to Detect DNA Strand Breaks. Erlangen, Germany, 29-31 March 1993.
Radiation and environmental biophysics 1994;33(1):85-8.
1993: Jochen Dahm-Daphi; Ekkehard Dikomey; C Pyttlik; Penny Jeggo
Reparable and non-reparable DNA strand breaks induced by X-irradiation in CHO K1 cells and the radiosensitive mutants xrs1 and xrs5.
International journal of radiation biology 1993;64(1):19-26.