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Yi Dai

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Masamichi Okubo; Hiroki Yamanaka; Yi Dai; Hirosato Kanda; Kimiko Kobayashi; Koichi Noguchi
Up-regulation of platelet-activating factor synthases and its receptor in spinal cord contribute to development of neuropathic pain following peripheral nerve injury.
Masamichi Okubo; Hiroki Yamanaka; Kimiko Kobayashi; Tetsuo Fukuoka; Yi Dai; Koichi Noguchi
Expression of leukotriene receptors in the rat dorsal root ganglion and the effects on pain behaviors.
Tetsuo Fukuoka; Kimiko Kobayashi; Hiroki Yamanaka; Koichi Obata; Yi Dai; Koichi Noguchi
Comparative study of the distribution of the alpha-subunits of voltage-gated sodium channels in normal and axotomized rat dorsal root ganglion neurons.

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All Publications

2012: Masamichi Okubo; Hiroki Yamanaka; Yi Dai; Hirosato Kanda; Kimiko Kobayashi; Koichi Noguchi
Up-regulation of platelet-activating factor synthases and its receptor in spinal cord contribute to development of neuropathic pain following peripheral nerve injury.
Molecular pain 2012;8():8.
2010: Masamichi Okubo; Hiroki Yamanaka; Kimiko Kobayashi; Tetsuo Fukuoka; Yi Dai; Koichi Noguchi
Expression of leukotriene receptors in the rat dorsal root ganglion and the effects on pain behaviors.
Molecular pain 2010;6():57.
2008: Tetsuo Fukuoka; Kimiko Kobayashi; Hiroki Yamanaka; Koichi Obata; Yi Dai; Koichi Noguchi
Comparative study of the distribution of the alpha-subunits of voltage-gated sodium channels in normal and axotomized rat dorsal root ganglion neurons.
The Journal of comparative neurology 2008;510(2):188-206.
2008: Koichi Obata; Hirokazu Katsura; Kan Miyoshi; Takashi Kondo; Hiroki Yamanaka; Kimiko Kobayashi; Yi Dai; Tetsuo Fukuoka; Shizuo Akira; Koichi Noguchi
Toll-like receptor 3 contributes to spinal glial activation and tactile allodynia after nerve injury.
Journal of neurochemistry 2008;105(6):2249-59.
2008: Shenglan Wang; Yi Dai; Tetsuo Fukuoka; Hiroki Yamanaka; Kimiko Kobayashi; Koichi Obata; Xiuyu Cui; Makoto Tominaga; Koichi Noguchi
Phospholipase C and protein kinase A mediate bradykinin sensitization of TRPA1: a molecular mechanism of inflammatory pain.
Brain : a journal of neurology 2008;131(Pt 5):1241-51.
2008: Hirokazu Katsura; Koichi Obata; Kan Miyoshi; Takashi Kondo; Hiroki Yamanaka; Kimiko Kobayashi; Yi Dai; Tetsuo Fukuoka; Masafumi Sakagami; Koichi Noguchi
Transforming growth factor-activated kinase 1 induced in spinal astrocytes contributes to mechanical hypersensitivity after nerve injury.
Glia 2008;56(7):723-33.
2008: Jun Sakurai; Koichi Obata; Noriyuki Ozaki; Atsushi Tokunaga; Kimiko Kobayashi; Hiroki Yamanaka; Yi Dai; Takashi Kondo; Kan Miyoshi; Yasuo Sugiura; Takayuki Matsumoto; Hiroto Miwa; Koichi Noguchi
Activation of extracellular signal-regulated protein kinase in sensory neurons after noxious gastric distention and its involvement in acute visceral pain in rats.
Gastroenterology 2008;134(4):1094-103.
2008: Kimiko Kobayashi; Hiroki Yamanaka; Tetsuo Fukuoka; Yi Dai; Koichi Obata; Koichi Noguchi
P2Y12 receptor upregulation in activated microglia is a gateway of p38 signaling and neuropathic pain.
The Journal of neuroscience : the official journal of the Society for Neuroscience 2008;28(11):2892-902.
2008: Xiu-Yu Cui; Yi Dai; Sheng-Lan Wang; Hiroki Yamanaka; Kimiko Kobayashi; Koichi Obata; Jun Chen; Koichi Noguchi
Differential activation of p38 and extracellular signal-regulated kinase in spinal cord in a model of bee venom-induced inflammation and hyperalgesia.
Molecular pain 2008;4():17.
2007: Hiroki Yamanaka; Koichi Obata; Kimiko Kobayashi; Yi Dai; Tetsuo Fukuoka; Koichi Noguchi
Activation of fibroblast growth factor receptor by axotomy, through downstream p38 in dorsal root ganglion, contributes to neuropathic pain.
Neuroscience 2007;150(1):202-11.
2007: Hirokazu Katsura; Koichi Obata; Toshiyuki Mizushima; Jun Sakurai; Kimiko Kobayashi; Hiroki Yamanaka; Yi Dai; Tetsuo Fukuoka; Masafumi Sakagami; Koichi Noguchi
Activation of extracellular signal-regulated protein kinases 5 in primary afferent neurons contributes to heat and cold hyperalgesia after inflammation.
Journal of neurochemistry 2007;102(5):1614-24.
2007: Koichi Obata; Hirokazu Katsura; Toshiyuki Mizushima; Jun Sakurai; Kimiko Kobayashi; Hiroki Yamanaka; Yi Dai; Tetsuo Fukuoka; Koichi Noguchi
Roles of extracellular signal-regulated protein kinases 5 in spinal microglia and primary sensory neurons for neuropathic pain.
Journal of neurochemistry 2007;102(5):1569-84.
2007: Yi Dai; Shenglan Wang; Makoto Tominaga; Satoshi Yamamoto; Tetsuo Fukuoka; Tomohiro Higashi; Kimiko Kobayashi; Koichi Obata; Hiroki Yamanaka; Koichi Noguchi
Sensitization of TRPA1 by PAR2 contributes to the sensation of inflammatory pain.
The Journal of clinical investigation 2007;117(7):1979-87.
2007: Toyoko Kozai; Hiroki Yamanaka; Yi Dai; Koichi Obata; Kimiko Kobayashi; Takashi Mashimo; Koichi Noguchi
Tissue type plasminogen activator induced in rat dorsal horn astrocytes contributes to mechanical hypersensitivity following dorsal root injury.
Glia 2007;55(6):595-603.
2007: Toshiyuki Mizushima; Koichi Obata; Hirokazu Katsura; Jun Sakurai; Kimiko Kobayashi; Hiroki Yamanaka; Yi Dai; Tetsuo Fukuoka; Takashi Mashimo; Koichi Noguchi
Intensity-dependent activation of extracellular signal-regulated protein kinase 5 in sensory neurons contributes to pain hypersensitivity.
The Journal of pharmacology and experimental therapeutics 2007;321(1):28-34.
2007: Hiroki Yamanaka; Koichi Obata; Kimiko Kobayashi; Yi Dai; Tetsuo Fukuoka; Koichi Noguchi
Alteration of the cell adhesion molecule L1 expression in a specific subset of primary afferent neurons contributes to neuropathic pain.
The European journal of neuroscience 2007;25(4):1097-111.
2007: Tomokazu Fukui; Yi Dai; Koichi Iwata; Hiroshi Kamo; Hiroki Yamanaka; Koichi Obata; Kimiko Kobayashi; Shenglan Wang; Xiuyu Cui; Shinichi Yoshiya; Koichi Noguchi
Frequency-dependent ERK phosphorylation in spinal neurons by electric stimulation of the sciatic nerve and the role in electrophysiological activity.
Molecular pain 2007;3():18.
2006: Koichi Obata; Hirokazu Katsura; Jun Sakurai; Kimiko Kobayashi; Hiroki Yamanaka; Yi Dai; Tetsuo Fukuoka; Koichi Noguchi
Suppression of the p75 neurotrophin receptor in uninjured sensory neurons reduces neuropathic pain after nerve injury.
The Journal of neuroscience : the official journal of the Society for Neuroscience 2006;26(46):11974-86.
2006: Kimiko Kobayashi; Tetsuo Fukuoka; Hiroki Yamanaka; Hirok Iyamanaka; Yi Dai; Koichi Obata; Atsushi Tokunaga; Koichi Noguchi
Neurons and glial cells differentially express P2Y receptor mRNAs in the rat dorsal root ganglion and spinal cord.
The Journal of comparative neurology 2006;498(4):443-54.
2006: Hirokazu Katsura; Koichi Obata; Toshiyuki Mizushima; Jun Sakurai; Kimiko Kobayashi; Hiroki Yamanaka; Yi Dai; Tetsuo Fukuoka; Masafumi Sakagami; Koichi Noguchi
Activation of Src-family kinases in spinal microglia contributes to mechanical hypersensitivity after nerve injury.
The Journal of neuroscience : the official journal of the Society for Neuroscience 2006;26(34):8680-90.
2006: Wan-Jun Zhu; Yi Dai; Tetsuo Fukuoka; Hiroki Yamanaka; Kimiko Kobayashi; Koichi Obata; Shenglan Wang; Koichi Noguchi
Agonist of proteinase-activated receptor 2 increases painful behavior produced by alpha, beta-methylene adenosine 5'-triphosphate.
Neuroreport 2006;17(12):1257-61.
2006: Toshiyuki Mizushima; Koichi Obata; Hirokazu Katsura; Hiroki Yamanaka; Kimiko Kobayashi; Yi Dai; Tetsuo Fukuoka; Atsushi Tokunaga; Takashi Mashimo; Koichi Noguchi
Noxious cold stimulation induces mitogen-activated protein kinase activation in transient receptor potential (TRP) channels TRPA1- and TRPM8-containing small sensory neurons.
Neuroscience 2006;140(4):1337-48.
2006: Daisuke Seino; Atsushi Tokunaga; Toshiya Tachibana; Shinichi Yoshiya; Yi Dai; Koichi Obata; Hiroki Yamanaka; Kimiko Kobayashi; Koichi Noguchi
The role of ERK signaling and the P2X receptor on mechanical pain evoked by movement of inflamed knee joint.
Pain 2006;123(1-2):193-203.
2006: Hirokazu Katsura; Koichi Obata; Toshiyuki Mizushima; Hiroki Yamanaka; Kimiko Kobayashi; Yi Dai; Tetsuo Fukuoka; Atsushi Tokunaga; Masafumi Sakagami; Koichi Noguchi
Antisense knock down of TRPA1, but not TRPM8, alleviates cold hyperalgesia after spinal nerve ligation in rats.
Experimental neurology 2006;200(1):112-23.
2006: Koichi Obata; Hiroki Yamanaka; Kimiko Kobayashi; Yi Dai; Toshiyuki Mizushima; Hirokazu Katsura; Tetsuo Fukuoka; Atsushi Tokunaga; Koichi Noguchi
The effect of site and type of nerve injury on the expression of brain-derived neurotrophic factor in the dorsal root ganglion and on neuropathic pain behavior.
Neuroscience 2006;137(3):961-70.
2005: Kimiko Kobayashi; Tetsuo Fukuoka; Koichi Obata; Hiroki Yamanaka; Yi Dai; Atsushi Tokunaga; Koichi Noguchi
Distinct expression of TRPM8, TRPA1, and TRPV1 mRNAs in rat primary afferent neurons with adelta/c-fibers and colocalization with trk receptors.
The Journal of comparative neurology 2005;493(4):596-606.
2005: Koichi Obata; Hirokazu Katsura; Toshiyuki Mizushima; Hiroki Yamanaka; Kimiko Kobayashi; Yi Dai; Tetsuo Fukuoka; Atsushi Tokunaga; Makoto Tominaga; Koichi Noguchi
TRPA1 induced in sensory neurons contributes to cold hyperalgesia after inflammation and nerve injury.
The Journal of clinical investigation 2005;115(9):2393-401.
2005: Yi Dai; Hu Wang; Akiko Ogawa; Hiroki Yamanaka; Koichi Obata; Atsushi Tokunaga; Koichi Noguchi
Ca2+/calmodulin-dependent protein kinase II in the spinal cord contributes to neuropathic pain in a rat model of mononeuropathy.
The European journal of neuroscience 2005;21(9):2467-74.
2005: Wan-Jun Zhu; Hiroki Yamanaka; Koichi Obata; Yi Dai; Kimiko Kobayashi; Toyoko Kozai; Atsushi Tokunaga; Koichi Noguchi
Expression of mRNA for four subtypes of the proteinase-activated receptor in rat dorsal root ganglia.
Brain research 2005;1041(2):205-11.
2005: Akiko Ogawa; Yi Dai; Hiroki Yamanaka; Koichi Iwata; Hitoshi Niwa; Koichi Noguchi
Ca(2+)/calmodulin-protein kinase IIalpha in the trigeminal subnucleus caudalis contributes to neuropathic pain following inferior alveolar nerve transection.
Experimental neurology 2005;192(2):310-9.
2005: Kimiko Kobayashi; Tetsuo Fukuoka; Hiroki Yamanaka; Yi Dai; Koichi Obata; Atsushi Tokunaga; Koichi Noguchi
Differential expression patterns of mRNAs for P2X receptor subunits in neurochemically characterized dorsal root ganglion neurons in the rat.
The Journal of comparative neurology 2005;481(4):377-90.
2005: Hiroki Yamanaka; Koichi Obata; Tetsuo Fukuoka; Yi Dai; Kimiko Kobayashi; Atsushi Tokunaga; Koichi Noguchi
Induction of plasminogen activator inhibitor-1 and -2 in dorsal root ganglion neurons after peripheral nerve injury.
Neuroscience 2005;132(1):183-91.
2005: Toshiyuki Mizushima; Koichi Obata; Hiroki Yamanaka; Yi Dai; Tetsuo Fukuoka; Atsushi Tokunaga; Takashi Mashimo; Koichi Noguchi
Activation of p38 MAPK in primary afferent neurons by noxious stimulation and its involvement in the development of thermal hyperalgesia.
Pain 2005;113(1-2):51-60.
2004: Koichi Obata; Hiroki Yamanaka; Yi Dai; Toshiyuki Mizushima; Tetsuo Fukuoka; Atsushi Tokunaga; Koichi Noguchi
Differential activation of MAPK in injured and uninjured DRG neurons following chronic constriction injury of the sciatic nerve in rats.
The European journal of neuroscience 2004;20(11):2881-95.
2004: Toshiya Tachibana; Hiroyuki Ogura; Atsushi Tokunaga; Yi Dai; Hiroki Yamanaka; Daisuke Seino; Koichi Noguchi
Plasma membrane calcium ATPase expression in the rat spinal cord.
Brain research. Molecular brain research 2004;131(1-2):26-32.
2004: Koichi Obata; Hiroki Yamanaka; Kimiko Kobayashi; Yi Dai; Toshiyuki Mizushima; Hirokazu Katsura; Tetsuo Fukuoka; Atsushi Tokunaga; Koichi Noguchi
Role of mitogen-activated protein kinase activation in injured and intact primary afferent neurons for mechanical and heat hypersensitivity after spinal nerve ligation.
The Journal of neuroscience : the official journal of the Society for Neuroscience 2004;24(45):10211-22.
2004: Koichi Obata; Hiroki Yamanaka; Yi Dai; Toshiyuki Mizushima; Tetsuo Fukuoka; Atsushi Tokunaga; Hideki Yoshikawa; Koichi Noguchi
Contribution of degeneration of motor and sensory fibers to pain behavior and the changes in neurotrophic factors in rat dorsal root ganglion.
Experimental neurology 2004;188(1):149-60.
2004: Yi Dai; Tomoko Moriyama; Tomohiro Higashi; Kazuya Togashi; Kimiko Kobayashi; Hiroki Yamanaka; Makoto Tominaga; Koichi Noguchi
Proteinase-activated receptor 2-mediated potentiation of transient receptor potential vanilloid subfamily 1 activity reveals a mechanism for proteinase-induced inflammatory pain.
The Journal of neuroscience : the official journal of the Society for Neuroscience 2004;24(18):4293-9.
2004: Yi Liu; Koichi Obata; Hiroki Yamanaka; Yi Dai; Tetsuo Fukuoka; Atsushi Tokunaga; Koichi Noguchi
Activation of extracellular signal-regulated protein kinase in dorsal horn neurons in the rat neuropathic intermittent claudication model.
Pain 2004;109(1-2):64-72.
2004: Yi Dai; Tetsuo Fukuoka; Hu Wang; Hiroki Yamanaka; Koichi Obata; Atsushi Tokunaga; Koichi Noguchi
Contribution of sensitized P2X receptors in inflamed tissue to the mechanical hypersensitivity revealed by phosphorylated ERK in DRG neurons.
Pain 2004;108(3):258-66.
2004: Hu Wang; Yi Dai; Tetsuo Fukuoka; Hiroki Yamanaka; Koichi Obata; Atsushi Tokunaga; Koichi Noguchi
Enhancement of stimulation-induced ERK activation in the spinal dorsal horn and gracile nucleus neurons in rats with peripheral nerve injury.
The European journal of neuroscience 2004;19(4):884-90.
2004: Koichi Obata; Hiroki Yamanaka; Yi Dai; Toshiyuki Mizushima; Tetsuo Fukuoka; Atsushi Tokunaga; Koichi Noguchi
Activation of extracellular signal-regulated protein kinase in the dorsal root ganglion following inflammation near the nerve cell body.
Neuroscience 2004;126(4):1011-21.
2004: Hiroki Yamanaka; Koichi Obata; Tetsuo Fukuoka; Yi Dai; Kimiko Kobayashi; Atsushi Tokunaga; Koichi Noguchi
Tissue plasminogen activator in primary afferents induces dorsal horn excitability and pain response after peripheral nerve injury.
The European journal of neuroscience 2004;19(1):93-102.
2003: Koichi Obata; Hiroki Yamanaka; Yi Dai; Toshiya Tachibana; Tetsuo Fukuoka; Atsushi Tokunaga; Hideki Yoshikawa; Koichi Noguchi
Differential activation of extracellular signal-regulated protein kinase in primary afferent neurons regulates brain-derived neurotrophic factor expression after peripheral inflammation and nerve injury.
The Journal of neuroscience : the official journal of the Society for Neuroscience 2003;23(10):4117-26.
2003: Yutaka Kominato; Toshiya Tachibana; Yi Dai; Hiroaki Tsujino; Souji Maruo; Koichi Noguchi
Changes in phosphorylation of ERK and Fos expression in dorsal horn neurons following noxious stimulation in a rat model of neuritis of the nerve root.
Brain research 2003;967(1-2):89-97.
2003: N Takahashi; S Kikuchi; Yi Dai; Kimiko Kobayashi; Tetsuo Fukuoka; Koichi Noguchi
Expression of auxiliary beta subunits of sodium channels in primary afferent neurons and the effect of nerve injury.
Neuroscience 2003;121(2):441-50.
2002: Yi Dai; Koichi Iwata; Tetsuo Fukuoka; Eiji Kondo; Atsushi Tokunaga; Hiroki Yamanaka; Toshiya Tachibana; Yi Liu; Koichi Noguchi
Phosphorylation of extracellular signal-regulated kinase in primary afferent neurons by noxious stimuli and its involvement in peripheral sensitization.
The Journal of neuroscience : the official journal of the Society for Neuroscience 2002;22(17):7737-45.
2002: Yi Liu; Toshiya Tachibana; Yi Dai; Eiji Kondo; Tetsuo Fukuoka; Hiroki Yamanaka; Koichi Noguchi
Heme oxygenase-1 expression after spinal cord injury: the induction in activated neutrophils.
Journal of neurotrauma 2002;19(4):479-90.
2002: Eiji Kondo; Koichi Iwata; Akiko Ogawa; Akimasa Tashiro; Yoshiyuki Tsuboi; Tetsuo Fukuoka; Hiroki Yamanaka; Yi Dai; Toshifumi Morimoto; Koichi Noguchi
Involvement of glutamate receptors on hyperexcitability of wide dynamic range neurons in the gracile nucleus of the rats with experimental mononeuropathy.
Pain 2002;95(1-2):153-63.
2001: Tetsuo Fukuoka; Eiji Kondo; Yi Dai; Norio Hashimoto; Koichi Noguchi
Brain-derived neurotrophic factor increases in the uninjured dorsal root ganglion neurons in selective spinal nerve ligation model.
The Journal of neuroscience : the official journal of the Society for Neuroscience 2001;21(13):4891-900.
2001: Norio Hashimoto; Hiroki Yamanaka; Tetsuo Fukuoka; Yi Dai; Koichi Obata; Takashi Mashimo; Koichi Noguchi
Expression of HGF and cMet in the peripheral nervous system of adult rats following sciatic nerve injury.
Neuroreport 2001;12(7):1403-7.
2001: Yi Dai; Koichi Iwata; Eiji Kondo; Toshifumi Morimoto; Koichi Noguchi
A selective increase in Fos expression in spinal dorsal horn neurons following graded thermal stimulation in rats with experimental mononeuropathy.
Pain 2001;90(3):287-96.
2000: K Miki; Koichi Iwata; Yoshiyuki Tsuboi; Toshifumi Morimoto; Eiji Kondo; Yi Dai; Ke Ren; Koichi Noguchi
Dorsal column-thalamic pathway is involved in thalamic hyperexcitability following peripheral nerve injury: a lesion study in rats with experimental mononeuropathy.
Pain 2000;85(1-2):263-71.
2000: Hiroaki Tsujino; Eiji Kondo; Tetsuo Fukuoka; Yi Dai; Atsushi Tokunaga; K Miki; Kazuo Yonenobu; T Ochi; Koichi Noguchi
Activating transcription factor 3 (ATF3) induction by axotomy in sensory and motoneurons: A novel neuronal marker of nerve injury.
Molecular and cellular neurosciences 2000;15(2):170-82.
2000: K Miki; Tetsuo Fukuoka; Atsushi Tokunaga; Eiji Kondo; Yi Dai; Koichi Noguchi
Differential effect of brain-derived neurotrophic factor on high-threshold mechanosensitivity in a rat neuropathic pain model.
Neuroscience letters 2000;278(1-2):85-8.
2000: Yi Dai; K Miki; Tetsuo Fukuoka; Atsushi Tokunaga; Toshiya Tachibana; Eiji Kondo; Koichi Noguchi
Suppression of neuropeptides' mRNA expression by herbal medicines in a rat model of peripheral inflammation.
Life sciences 2000;66(1):19-29.
1999: Atsushi Tokunaga; Eiji Kondo; Tetsuo Fukuoka; K Miki; Yi Dai; Hiroaki Tsujino; Koichi Noguchi
Excitability of spinal cord and gracile nucleus neurons in rats with chronically injured sciatic nerve examined by c-fos expression.
Brain research 1999;847(2):321-31.