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Glenn Dale

Research Profile

Procedures

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Chemicals & Drugs

Physiology

Trimethoprim Resistance

Genes & Molecular Sequences

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Protein Binding

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Publications

TOP 3
Christian Oefner; Sabine Pierau; Henk Schulz; Glenn E Dale
Structural studies of a bifunctional inhibitor of neprilysin and DPP-IV.
Christian Oefner; Henk Schulz; Allan D'Arcy; Glenn E Dale
Mapping the active site of Escherichia coli malonyl-CoA-acyl carrier protein transacylase (FabD) by protein crystallography.
Aengus Mac Sweeney; Roland Lange; Roberta P M Fernandes; Henk Schulz; Glenn E Dale; Alice Douangamath; Philip J Proteau; Christian Oefner
The crystal structure of E.coli 1-deoxy-D-xylulose-5-phosphate reductoisomerase in a ternary complex with the antimalarial compound fosmidomycin and NADPH reveals a tight-binding closed enzyme conformation.

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All Publications

2007: Christian Oefner; Sabine Pierau; Henk Schulz; Glenn E Dale
Structural studies of a bifunctional inhibitor of neprilysin and DPP-IV.
Acta crystallographica. Section D, Biological crystallography 2007;63(Pt 9):975-81.
2006: Christian Oefner; Henk Schulz; Allan D'Arcy; Glenn E Dale
Mapping the active site of Escherichia coli malonyl-CoA-acyl carrier protein transacylase (FabD) by protein crystallography.
Acta crystallographica. Section D, Biological crystallography 2006;62(Pt 6):613-8.
2005: Aengus Mac Sweeney; Roland Lange; Roberta P M Fernandes; Henk Schulz; Glenn E Dale; Alice Douangamath; Philip J Proteau; Christian Oefner
The crystal structure of E.coli 1-deoxy-D-xylulose-5-phosphate reductoisomerase in a ternary complex with the antimalarial compound fosmidomycin and NADPH reveals a tight-binding closed enzyme conformation.
Journal of molecular biology 2005;345(1):115-27.
2004: Alice Douangamath; Glenn E Dale; Allan D'Arcy; Michael Almstetter; Robert Eckl; Annabelle Frutos-Hoener; Bernd Henkel; Katrin Illgen; Sven Nerdinger; Henk Schulz; Aengus Mac Sweeney; Aengus MacSweeney; Michael Thormann; Andreas Treml; Sabine Pierau; Sjoerd Wadman; Christian Oefner
Crystal structures of Staphylococcusaureus methionine aminopeptidase complexed with keto heterocycle and aminoketone inhibitors reveal the formation of a tetrahedral intermediate.
Journal of medicinal chemistry 2004;47(6):1325-8.
2004: Christian Oefner; Bernard P Roques; Marie-Claude Fournie-Zaluski; Glenn E Dale
Structural analysis of neprilysin with various specific and potent inhibitors.
Acta crystallographica. Section D, Biological crystallography 2004;60(Pt 2):392-6.
2003: Christian Oefner; Alice Douangamath; Allan D'Arcy; Sascha Häfeli; Daniel Mareque; Aengus Mac Sweeney; Juan Padilla; Sabine Pierau; Henk Schulz; Michael Thormann; Sjoerd Wadman; Glenn E Dale
The 1.15A crystal structure of the Staphylococcus aureus methionyl-aminopeptidase and complexes with triazole based inhibitors.
Journal of molecular biology 2003;332(1):13-21.
2003: Juliette Molnos; Rana Gardiner; Glenn E Dale; Roland Lange
A continuous coupled enzyme assay for bacterial malonyl-CoA:acyl carrier protein transacylase (FabD).
Analytical biochemistry 2003;319(1):171-6.
2003: Christian Oefner; Allan D'Arcy; Aengus Mac Sweeney; Sabine Pierau; Rana Gardiner; Glenn E Dale
High-resolution structure of human apo dipeptidyl peptidase IV/CD26 and its complex with 1-[([2-[(5-iodopyridin-2-yl)amino]-ethyl]amino)-acetyl]-2-cyano-(S)-pyrrolidine.
Acta crystallographica. Section D, Biological crystallography 2003;59(Pt 7):1206-12.
2003: Glenn E Dale; Christian Oefner; Allan D'Arcy
The protein as a variable in protein crystallization.
Journal of structural biology 2003;142(1):88-97.
2001: Dirk Kostrewa; Manfred Brockhaus; Allan D'Arcy; Glenn E Dale; Peter Nelboeck; G Schmid; F Mueller; Gianfranco Bazzoni; Elisabetta Dejana; Tamas Bartfai; Fritz K Winkler; M Hennig
X-ray structure of junctional adhesion molecule: structural basis for homophilic adhesion via a novel dimerization motif.
The EMBO journal 2001;20(16):4391-8.
2001: Daniel Bur; Glenn E Dale; Christian Oefner
A three-dimensional model of endothelin-converting enzyme (ECE) based on the X-ray structure of neutral endopeptidase 24.11 (NEP).
Protein engineering 2001;14(5):337-41.
2000: Glenn E Dale; B D'Arcy; C Yuvaniyama; B Wipf; Christian Oefner; Allan D'Arcy
Purification and crystallization of the extracellular domain of human neutral endopeptidase (neprilysin) expressed in Pichia pastoris.
Acta crystallographica. Section D, Biological crystallography 2000;56(Pt 7):894-7.
2000: Christian Oefner; Allan D'Arcy; M Hennig; Fritz K Winkler; Glenn E Dale
Structure of human neutral endopeptidase (Neprilysin) complexed with phosphoramidon.
Journal of molecular biology 2000;296(2):341-9.
1999: Glenn E Dale; Dirk Kostrewa; B Gsell; M Stieger; Allan D'Arcy
Crystal engineering: deletion mutagenesis of the 24 kDa fragment of the DNA gyrase B subunit from Staphylococcus aureus.
Acta crystallographica. Section D, Biological crystallography 1999;55(Pt 9):1626-9.
1999: Allan D'Arcy; Martine Stihle; Dirk Kostrewa; Glenn E Dale
Crystal engineering: a case study using the 24 kDa fragment of the DNA gyrase B subunit from Escherichia coli.
Acta crystallographica. Section D, Biological crystallography 1999;55(Pt 9):1623-5.
1999: M Hennig; Glenn E Dale; Allan D'Arcy; Franck Danel; S Fischer; C P Gray; S Jolidon; F Müller; Malcolm G P Page; P Pattison; Christian Oefner
The structure and function of the 6-hydroxymethyl-7,8-dihydropterin pyrophosphokinase from Haemophilus influenzae.
Journal of molecular biology 1999;287(2):211-9.
1998: M Hennig; Allan D'Arcy; I C Hampele; Malcolm G P Page; Christian Oefner; Glenn E Dale
Crystal structure and reaction mechanism of 7,8-dihydroneopterin aldolase from Staphylococcus aureus.
Nature structural biology 1998;5(5):357-62.
1997: I C Hampele; Allan D'Arcy; Glenn E Dale; Dirk Kostrewa; J Nielsen; Christian Oefner; Malcolm G P Page; Hans-Joachim Schönfeld; D Stüber; Rudolf L Then
Structure and function of the dihydropteroate synthase from Staphylococcus aureus.
Journal of molecular biology 1997;268(1):21-30.
1997: Glenn E Dale; C Broger; Allan D'Arcy; P G Hartman; R DeHoogt; S Jolidon; I Kompis; Alexander Michael Labhardt; Hanno Langen; Hans H Locher; Malcolm G P Page; D Stüber; Rudolf L Then; B Wipf; Christian Oefner
A single amino acid substitution in Staphylococcus aureus dihydrofolate reductase determines trimethoprim resistance.
Journal of molecular biology 1997;266(1):23-30.
1995: Glenn E Dale; H Langen; Malcolm G P Page; Rudolf L Then; D Stüber
Cloning and characterization of a novel, plasmid-encoded trimethoprim-resistant dihydrofolate reductase from Staphylococcus haemolyticus MUR313.
Antimicrobial agents and chemotherapy 1995;39(9):1920-4.
1995: Glenn E Dale; C Broger; P G Hartman; H Langen; Malcolm G P Page; Rudolf L Then; D Stüber
Characterization of the gene for the chromosomal dihydrofolate reductase (DHFR) of Staphylococcus epidermidis ATCC 14990: the origin of the trimethoprim-resistant S1 DHFR from Staphylococcus aureus?
Journal of bacteriology 1995;177(11):2965-70.
1994: Glenn E Dale; C Broger; H Langen; Allan D'Arcy; D Stüber
Improving protein solubility through rationally designed amino acid replacements: solubilization of the trimethoprim-resistant type S1 dihydrofolate reductase.
Protein engineering 1994;7(7):933-9.
1994: Glenn E Dale; H J Schönfeld; H Langen; M Stieger
Increased solubility of trimethoprim-resistant type S1 DHFR from Staphylococcus aureus in Escherichia coli cells overproducing the chaperonins GroEL and GroES.
Protein engineering 1994;7(7):925-31.
1993: Glenn E Dale; Rudolf L Then; D Stüber
Characterization of the gene for chromosomal trimethoprim-sensitive dihydrofolate reductase of Staphylococcus aureus ATCC 25923.
Antimicrobial agents and chemotherapy 1993;37(7):1400-5.
1993: Glenn E Dale; D Stüber; C Broger; H Langen
Expression of the trimethoprim resistant dihydrofolate reductase encoded by transposon TN4003 in a soluble form and its subsequent purification to homogeneity.
Advances in experimental medicine and biology 1993;338():541-4.