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George Daley

Research Profile

Living Beings

Mouse

Physiology

Anatomy

Chemicals & Drugs

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Leukemia, Myelogenous, Chronic, BCR-ABL Positive

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TOP 3
Patrick Cahan; George Q Daley
Origins and implications of pluripotent stem cell variability and heterogeneity.
Gen Shinoda; Akiko Yabuuchi; T Yvanka De Soysa; Yuko Fujiwara; Richard I Gregory; John P Hagan; Pei Yi Huang; Eric G Moss; Marc T Seligson; George Q Daley
Lin28a regulates germ cell pool size and fertility.
Marcella Cesana; George Q Daley
Deciphering the rules of ceRNA networks.

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All Publications

2013: Patrick Cahan; George Q Daley
Origins and implications of pluripotent stem cell variability and heterogeneity.
Nature reviews. Molecular cell biology 2013;14(6):357-68.
2013: Gen Shinoda; Akiko Yabuuchi; T Yvanka De Soysa; Yuko Fujiwara; Richard I Gregory; John P Hagan; Pei Yi Huang; Eric G Moss; Marc T Seligson; George Q Daley
Lin28a regulates germ cell pool size and fertility.
Stem cells (Dayton, Ohio) 2013;31(5):1001-9.
2013: Marcella Cesana; George Q Daley
Deciphering the rules of ceRNA networks.
Proceedings of the National Academy of Sciences of the United States of America 2013;110(18):7112-3.
2013: Ng Shyh-Chang; George Q Daley
Lin28: primal regulator of growth and metabolism in stem cells.
Cell stem cell 2013;12(4):395-406.
2013: Ng Shyh-Chang; Ren Yi Teo; Juli J Unternaehrer; Jin Zhang; Yuxiang Zheng; Hao Zhu; George Q Daley; Jason W Locasale; Costas A Lyssiotis; Tamer Onder; Sutheera Ratanasirintrawoot; John M Asara; Lewis C Cantley
Influence of threonine metabolism on S-adenosylmethionine and histone methylation.
Science (New York, N.Y.) 2013;339(6116):222-6.
2013: Peter Geon Kim; M William Lensch; Yoowon Lim; Michelle I Lin; Sabine Loewer; Yi-fen Lu; Leonard I Zon; Colleen E Albacker; Natasha Arora; Teresa V Bowman; Alejandro De Los Angeles; Garrett C Heffner; Il-ho Jang; George Q Daley
Signaling axis involving Hedgehog, Notch, and Scl promotes the embryonic endothelial-to-hematopoietic transition.
Proceedings of the National Academy of Sciences of the United States of America 2013;110(2):E141-50.
2013: Anne B C Cherry; George Q Daley
Reprogrammed cells for disease modeling and regenerative medicine.
Annual review of medicine 2013;64():277-90.
2013: Samantha A Morris; George Q Daley
A blueprint for engineering cell fate: current technologies to reprogram cell identity.
Cell research 2013;23(1):33-48.
2012: George Q Daley
Cellular alchemy and the golden age of reprogramming.
Cell 2012;151(6):1151-4.
2012: Vivek K Bajpai; George Q Daley; Yuin-Han Loh; Panagiotis Mistriotis; Stelios T Andreadis
Functional vascular smooth muscle cells derived from human induced pluripotent stem cells via mesenchymal stem cell intermediates.
Cardiovascular research 2012;96(3):391-400.
2012: Fabien G Lafaille; Gustavo Mostoslavsky; Laurent Abel; Avinash Abhyankar; Saleh Al-Muhsen; Jean-Laurent Casanova; Michael J Ciancanelli; George Q Daley; Yechiel Elkabetz; Peter A Goldstein; Melina Herman; Emmanuelle Jouanguy; Sotirios Keros; Jose Ordovas-Montanes; Itai Pessach; Sabine Plancoulaine; Thorsten M Schlaeger; Studer Lorenz; Marc Tardieu; Edmund Tu; Shui-Wang Ying; Shen-Ying Zhang; Luigi D Notarangelo
Impaired intrinsic immunity to HSV-1 in human iPSC-derived TLR3-deficient CNS cells.
Nature 2012;491(7426):769-73.
2012: Shannon L McKinney-Freeman; Olaia Naveiras; Leonard I Zon; Patrick Cahan; James J Collins; Matthew Curran; Hsuan-Ting Huang; Katie L Kathrein; Martina Konantz; Scott A Lacadie; Erin M Langdon; Claudia Lengerke; Hu Li; Sabine Loewer; George Q Daley
The transcriptional landscape of hematopoietic stem cell ontogeny.
Cell stem cell 2012;11(5):701-14.
2012: Jin Zhang; George Q Daley; Carla M Koehler; Esther Nuebel; Michael A Teitell
Metabolic Regulation in Pluripotent Stem Cells during Reprogramming and Self-Renewal.
Cell stem cell 2012;11(5):589-95.
2012: Glenn A Maclean; Tobias F Menne; George Q Daley; Guoji Guo; In-Hyun Park; Danielle J Sanchez; Stuart H Orkin
Altered hematopoiesis in trisomy 21 as revealed through in vitro differentiation of isogenic human pluripotent cells.
Proceedings of the National Academy of Sciences of the United States of America 2012;109(43):17567-72.
2012: Tamer T Onder; George Q Daley
New lessons learned from disease modeling with induced pluripotent stem cells.
Current opinion in genetics & development 2012;22(5):500-8.
2012: Jung-Il Chae; Nag-Jin Choi; George Q Daley; Jeong Tae Do; Iksoo Jeon; Young-Joo Jeon; Sung Hyun Kang; Dong-Wook Kim; Jumi Kim; Jihye Kwon; Dong Ryul Lee; Dong-Seok Lee; Nayeon Lee; Seung-Hun Oh; Byoung Chul Park; In-Hyun Park; Joohyun Ryu; Kang Seok Seo; Dong Ah Shin; Yunjo Soh; Jihwan Song
Quantitative proteomic analysis of induced pluripotent stem cells derived from a human Huntington's disease patient.
The Biochemical journal 2012;446(3):359-71.
2012: Iksoo Jeon; Kyung-Sun Kang; Hyun Sook Kim; Manho Kim; Jihye Kwon; Dong Ryul Lee; Nayeon Lee; Jia-Yi Li; Jisook Moon; Seung-Hun Oh; In-Hyun Park; Kyoung Sun Park; Sung Han Shim; Dong Ah Shin; Patrik Brundin; Da-Jeong Chang; Chunggab Choi; George Q Daley; Jeong Tae Do; Jihwan Song
Neuronal properties, in vivo effects, and pathology of a Huntington's disease patient-derived induced pluripotent stem cells.
Stem cells (Dayton, Ohio) 2012;30(9):2054-62.
2012: Claudia Lengerke; George Q Daley
Caudal genes in blood development and leukemia.
Annals of the New York Academy of Sciences 2012;1266():47-54.
2012: Cédric Blanpain; George Q Daley; Konrad Hochedlinger; Emmanuelle Passegué; Janet Rossant; Shinya Yamanaka
Stem cells assessed.
Nature reviews. Molecular cell biology 2012;13(7):471-6.
2012: George Q Daley
The promise and perils of stem cell therapeutics.
Cell stem cell 2012;10(6):740-9.
2012: Lars U Mueller; In-Hyun Park; Kalindi Parmar; Axel Schambach; Thorsten Schlaeger; Kelly Strait; Rutesh Vyas; Kristina M Brumme; George Q Daley; Alan D'Andrea; Alexander L Devine; Elke Grassman; Chad E Harris; Wendy B London; Michael D Milsom; Lisa A Moreau; David A Williams
Overcoming reprogramming resistance of Fanconi anemia cells.
Blood 2012;119(23):5449-57.
2012: Alejandro De Los Angeles; Yuin-Han Loh; Paul J Tesar; George Q Daley
Accessing naïve human pluripotency.
Current opinion in genetics & development 2012;22(3):272-82.
2012: Xiao Guan; Hongguang Huo; George Q Daley; Elizabeth Ginsberg; Catherine Racowsky; Akiko Yabuuchi; Paul H Lerou
Derivation of human embryonic stem cells with NEMO deficiency.
Stem cell research 2012;8(3):410-5.
2012: Bilada Bilican; Monica Carrasco; Sami J Barmada; George Q Daley; Steven Finkbeiner; Judy Fletcher; Brad A Friedman; Giles E Hardingham; Tom Maniatis; Agnes Lumi Nishimura; In-Hyun Park; Hemali P Phatnani; Clare A Puddifoot; Andrea Serio; Christopher E Shaw; David Story; Gareth J Sullivan; Ian Wilmut; David J A Wyllie; Siddharthan Chandran
Mutant induced pluripotent stem cell lines recapitulate aspects of TDP-43 proteinopathies and reveal cell-specific vulnerability.
Proceedings of the National Academy of Sciences of the United States of America 2012;109(15):5803-8.
2012: Natasha Arora; George Q Daley
Pluripotent stem cells in research and treatment of hemoglobinopathies.
Cold Spring Harbor perspectives in medicine 2012;2(4):a011841.
2012: Tamer T Onder; Amit U Sinha; Juli Unternaehrer; Nan Zhu; Scott A Armstrong; Kathrin Maria Bernt; Patrick Cahan; Anne Cherry; Piyush B Gupta; Nergis Kara; Eric S Lander; B Ogan Marcarci; George Q Daley
Chromatin-modifying enzymes as modulators of reprogramming.
Nature 2012;483(7391):598-602.
2012: Anne B C Cherry; George Q Daley
Reprogramming cellular identity for regenerative medicine.
Cell 2012;148(6):1110-22.
2012: Cong Xu; Richard A Young; George Q Daley; Anthony DiBiase; Todd Evans; Zi Peng Fan; Rachel Fogley; Sean G Megason; Patrick Müller; Alexander F Schier; Ingrid Torregroza; Eirini Trompouki; Juli Unternaehrer; Fengzhu Xiong; Leonard I Zon
Nanog-like regulates endoderm formation through the Mxtx2-Nodal pathway.
Developmental cell 2012;22(3):625-38.
2012: Aibin He; Michael Hsing; Sek Won Kong; Qing Ma; Stuart H Orkin; Patrick Cahan; Jingjing Cao; Danos C Christodoulou; George Q Daley; Christine E Seidman; Jonathan G Seidman; Alexander von Gise; Huafeng Xie; Bing Zhang; Pingzhu Zhou; William T Pu
Polycomb repressive complex 2 regulates normal development of the mouse heart.
Circulation research 2012;110(3):406-15.
2012: Daisy A Robinton; George Q Daley
The promise of induced pluripotent stem cells in research and therapy.
Nature 2012;481(7381):295-305.
2012: Matthew R Jones; Elyse Kozlowski; Kori Y Matsuura; Matthew T Blahna; George Q Daley; Joseph D Ferrari; Samantha A Morris; John T Powers; Lee J Quinton; Joseph P Mizgerd
Zcchc11 uridylates mature miRNAs to enhance neonatal IGF-1 expression, growth, and survival.
PLoS genetics 2012;8(11):e1003105.
2012: Bo Wen; Hao Wu; Eirikur Briem; George Q Daley; Yuin-Han Loh; Andrew P Feinberg
Euchromatin islands in large heterochromatin domains are enriched for CTCF binding and differentially DNA-methylated regions.
BMC genomics 2012;13():566.
2012: Yuin-Han Loh; In-Hyun Park; Derrick J Rossi; Jimmy Chen Yang; Alejandro De Los Angeles; Anne Cherry; Chunguang Guo; George Q Daley
Excision of a viral reprogramming cassette by delivery of synthetic Cre mRNA.
Current protocols in stem cell biology 2012;Chapter 4():Unit4A.5.
2011: Philip D Manos; Sutheera Ratanasirintrawoot; George Q Daley; Sabine Loewer; Thorsten M Schlaeger
Live-cell immunofluorescence staining of human pluripotent stem cells.
Current protocols in stem cell biology 2011;Chapter 1():Unit 1C.12.
2011: Kitai Kim; M William Lensch; Hu Li; Yuin-Han Loh; Kitwa Ng; Juli Unternaehrer; Rui Zhao; Martin Aryee; Patrick Cahan; James J Collins; Akiko Doi; Andrew P Feinberg; Hongguang Huo; George Q Daley
Donor cell type can influence the epigenome and differentiation potential of human induced pluripotent stem cells.
Nature biotechnology 2011;29(12):1117-9.
2011: Marica Grskovic; Ashkan Javaherian; Berta Strulovici; George Q Daley
Induced pluripotent stem cells--opportunities for disease modelling and drug discovery.
Nature reviews. Drug discovery 2011;10(12):915-29.
2011: Andrea Ballabeni; George Q Daley; Paul H Lerou; In-Hyun Park; Weiping Wang; Rui Zhao; Marc W Kirschner
Cell cycle adaptations of embryonic stem cells.
Proceedings of the National Academy of Sciences of the United States of America 2011;108(48):19252-7.
2011: Eirini Trompouki; Dai-Chen Wu; Richard A Young; Teresa V Bowman; Jennifer N Cech; George Q Daley; Anthony DiBiase; Ellen M Durand; Zi Peng Fan; Garrett C Heffner; Lee N Lawton; Jocelyn L Leblanc; Pulin Li; Corey S Martin; Christian Mosimann; Robert F Paulson; Anna K Sessa; Leonard I Zon
Lineage regulators direct BMP and Wnt pathways to cell-specific programs during differentiation and regeneration.
Cell 2011;147(3):577-89.
2011: George Q Daley; Jan Helge Solbakk
Stem cells: Triple genomes go far.
Nature 2011;478(7367):40-1.
2011: Tse-Chun Kuo; Sabine Loewer; Tamer T Onder; Cara M Weismann; Ping Xu; Sandra Almeida; Desiree Baron; Chun-Ting Chen; George Q Daley; Fen-Biao Gao; Jean-Marie Houghton; Stephen J Doxsey
Midbody accumulation through evasion of autophagy contributes to cellular reprogramming and tumorigenicity.
Nature cell biology 2011;13(10):1214-23.
2011: Hao Zhu; David Altshuler; William S Einhorn; Jesse M Engreitz; Richard I Gregory; John Patrick Hagan; Michael G Kharas; Ayellet V Segrè; Samar P Shah; Gen Shinoda; Ng Shyh-Chang; Ayumu Takeuchi; James E Thornton; Robinson Triboulet; Achia Urbach; George Q Daley
The Lin28/let-7 axis regulates glucose metabolism.
Cell 2011;147(1):81-94.
2011: Yuin-Han Loh; Jimmy Chen Yang; Lin Yang; James J Collins; Hu Li; George Q Daley
Genomic approaches to deconstruct pluripotency.
Annual review of genomics and human genetics 2011;12():165-85.
2011: Jiho Jang; Hoon-Chul Kang; Dae-Sung Kim; George Q Daley; Yong Jun Huh; Dong-Youn Hwang; Han-Soo Kim; Ji Young Kim; Jiwon Lee; Jeong-Ah Lee; Boyoung Lim; In-Hyun Park; Jeong-Eun Yoo; Tae-Min Yoon; Dong-Wook Kim
Induced pluripotent stem cell models from X-linked adrenoleukodystrophy patients.
Annals of neurology 2011;70(3):402-9.
2011: Caroline H Yi; Bo Zhai; John M Asara; Lewis C Cantley; George Q Daley; Steven P Gygi; Gregory J Heffron; Sven G Hyberts; Il-Ho Jang; Fupeng Li; Chuan-Fa Liu; Jason W Locasale; Harry Luithardt; Heling Pan; Ricard Rodriguez-Mias; Jan Seebacher; Hadar Sharfi; Matthew G Vander Heiden; Gerhard Wagner; Renliang Yang; Junying Yuan
Metabolic regulation of protein N-alpha-acetylation by Bcl-xL promotes cell survival.
Cell 2011;146(4):607-20.
2011: Juli J Unternaehrer; George Q Daley
Induced pluripotent stem cells for modelling human diseases.
Philosophical transactions of the Royal Society of London. Series B, Biological sciences 2011;366(1575):2274-85.
2011: Aijun Wang; Zhenyu Tang; In-Hyun Park; Yiqian Zhu; Shyam Patel; George Q Daley; Song Li
Induced pluripotent stem cells for neural tissue engineering.
Biomaterials 2011;32(22):5023-32.
2011: Hiroyuki Higashi; Oliver Brüstle; George Q Daley; Shinya Yamanaka
The nomenclature system should be sustainable, but also practical.
Cell stem cell 2011;8(6):606-7.
2011: Claudia Lengerke; Rebecca Wingert; Michael Beeretz; Matthias Grauer; Anne G Schmidt; Martina Konantz; George Q Daley; Alan J Davidson
Interactions between Cdx genes and retinoic acid modulate early cardiogenesis.
Developmental biology 2011;354(1):134-42.
2011: Itai Pessach; Jose Ordovas-Montanes; Shen-Ying Zhang; Jean-Laurent Casanova; Silvia Giliani; Andrew R Gennery; Waleed Al-Herz; Philip D Manos; Thorsten M Schlaeger; In-Hyun Park; Francesca Rucci; Suneet Agarwal; Gustavo Mostoslavsky; George Q Daley; Luigi D Notarangelo
Induced pluripotent stem cells: a novel frontier in the study of human primary immunodeficiencies.
The Journal of allergy and clinical immunology 2011;127(6):1400-7.e4.
2011: William A Pastor; Utz J Pape; Yun Huang; Hope R Henderson; Ryan Lister; Myunggon Ko; Erin M McLoughlin; Yevgeny Brudno; Sahasransu Mahapatra; Philipp Kapranov; Mamta Tahiliani; George Q Daley; X Shirley Liu; Joseph R Ecker; Patrice M Milos; Suneet Agarwal; Anjana Rao
Genome-wide mapping of 5-hydroxymethylcytosine in embryonic stem cells.
Nature 2011;473(7347):394-7.
2011: Hao Zhu; M William Lensch; Patrick Cahan; George Q Daley
Investigating monogenic and complex diseases with pluripotent stem cells.
Nature reviews. Genetics 2011;12(4):266-75.
2011: Athurva Gore; Zhe Li; Ho-Lim Fung; Jessica E Young; Suneet Agarwal; Jessica Antosiewicz-Bourget; Isabel Canto; Alessandra Giorgetti; Mason A Israel; Evangelos Kiskinis; Je-Hyuk Lee; Yuin-Han Loh; Philip D Manos; Nuria Montserrat; Athanasia D Panopoulos; Sergio Ruiz; Melissa L Wilbert; Junying Yu; Ewen F Kirkness; Juan Carlos Izpisua-Belmonte; Derrick J Rossi; James A Thomson; Kevin Eggan; George Q Daley; Lawrence S B Goldstein; Kun Zhang
Somatic coding mutations in human induced pluripotent stem cells.
Nature 2011;471(7336):63-7.
2011: M Cristina Nostro; Farida Sarangi; Shinichiro Ogawa; Audrey Holtzinger; Barbara Corneo; Xueling Li; Suzanne J Micallef; In-Hyun Park; Christina Basford; Michael B Wheeler; George Q Daley; Andrew G Elefanty; Edouard G Stanley; Gordon Keller
Stage-specific signaling through TGFβ family members and WNT regulates patterning and pancreatic specification of human pluripotent stem cells.
Development (Cambridge, England) 2011;138(5):861-71.
2011: Kian Peng Koh; Akiko Yabuuchi; Sridhar Rao; Yun Huang; Kerrianne Cunniff; Julie Nardone; Asta Laiho; Mamta Tahiliani; Cesar A Sommer; Gustavo Mostoslavsky; Riitta Lahesmaa; Stuart H Orkin; Scott J Rodig; George Q Daley; Anjana Rao
Tet1 and Tet2 regulate 5-hydroxymethylcytosine production and cell lineage specification in mouse embryonic stem cells.
Cell stem cell 2011;8(2):200-13.
2011: Jakub Tolar; In-Hyun Park; Lily Xia; Chris J Lees; Brandon Peacock; Beau Webber; Ron T McElmurry; Cindy R Eide; Paul J Orchard; Michael Kyba; Mark J Osborn; Troy Lund; John E Wagner; George Q Daley; Bruce R Blazar
Hematopoietic differentiation of induced pluripotent stem cells from patients with mucopolysaccharidosis type I (Hurler syndrome).
Blood 2011;117(3):839-47.
2011: Tamer T Onder; George Q Daley
microRNAs become macro players in somatic cell reprogramming.
Genome medicine 2011;3(6):40.
2011: Budd A Tucker; In-Hyun Park; Sara D Qi; Henry J Klassen; Caihui Jiang; Jing Yao; Stephen Redenti; George Q Daley; Michael J Young
Transplantation of adult mouse iPS cell-derived photoreceptor precursors restores retinal structure and function in degenerative mice.
PloS one 2011;6(4):e18992.
2011: Margaret L MacMillan; Mark R Hughes; Suneet Agarwal; George Q Daley
Cellular therapy for fanconi anemia: the past, present, and future.
Biology of blood and marrow transplantation : journal of the American Society for Blood and Marrow Transplantation 2011;17(1 Suppl):S109-14.
2010: Pierre Neveu; Min Jeong Kye; Shuping Qi; David E Buchholz; Dennis O Clegg; Mustafa Sahin; In-Hyun Park; Kwang-Soo Kim; George Q Daley; Harley I Kornblum; Boris I Shraiman; Kenneth S Kosik
MicroRNA profiling reveals two distinct p53-related human pluripotent stem cell states.
Cell stem cell 2010;7(6):671-81.
2010: Anne Cherry; George Q Daley
Another horse in the meta-stable state of pluripotency.
Cell stem cell 2010;7(6):641-2.
2010: Michael G Kharas; George Q Daley
From Hen House to Bedside: Tracing Hanafusa's Legacy from Avian Leukemia Viruses to SRC to ABL and Beyond.
Genes & cancer 2010;1(12):1164-9.
2010: Sabine Loewer; Moran N Cabili; Mitchell Guttman; Yuin-Han Loh; Kelly Thomas; In Hyun Park; Manuel Garber; Matthew Curran; Tamer Onder; Suneet Agarwal; Philip D Manos; Sumon Datta; Eric S Lander; Thorsten M Schlaeger; George Q Daley; John L Rinn
Large intergenic non-coding RNA-RoR modulates reprogramming of human induced pluripotent stem cells.
Nature genetics 2010;42(12):1113-7.
2010: Luigi Warren; Philip D Manos; Tim Ahfeldt; Yuin-Han Loh; Hu Li; Frank Lau; Wataru Ebina; pankaj k mandal; Zachary D Smith; Alexander Meissner; George Q Daley; Andrew S Brack; James J Collins; Chad Cowan; Thorsten M Schlaeger; Derrick J Rossi
Highly efficient reprogramming to pluripotency and directed differentiation of human cells with synthetic modified mRNA.
Cell stem cell 2010;7(5):618-30.
2010: Sumin Koo; Brian J Huntly; Yuan Wang; Jing Chen; Kristina Brumme; Brian Ball; Shannon L McKinney-Freeman; Akiko Yabuuchi; Claudia Scholl; Dimple Bansal; Leonard I Zon; Stefan Fröhling; George Q Daley; D Gary Gilliland; Thomas Mercher
Cdx4 is dispensable for murine adult hematopoietic stem cells but promotes MLL-AF9-mediated leukemogenesis.
Haematologica 2010;95(10):1642-50.
2010: Hong Ji; Lauren I R Ehrlich; Jun Seita; Peter Murakami; Akiko Doi; Paul Lindau; Hwajin Lee; Martin Aryee; Rafael A Irizarry; Kitai Kim; Derrick J Rossi; Matthew A Inlay; Thomas Serwold; Holger Karsunky; Lena Ho; George Q Daley; Irving L Weissman; Andrew P Feinberg
Comprehensive methylome map of lineage commitment from haematopoietic progenitors.
Nature 2010;467(7313):338-42.
2010: K Kim; A Doi; Bo Wen; K Ng; R Zhao; Patrick Cahan; Jonghwan Kim; Martin Aryee; Hongxiu Ji; L I R Ehrlich; A Yabuuchi; A Takeuchi; K C Cunniff; H Hongguang; S McKinney-Freeman; O Naveiras; T J Yoon; Rafael A Irizarry; N Jung; J Seita; J Hanna; P Murakami; Rudolf Jaenisch; R Weissleder; S H Orkin; I L Weissman; Andrew P Feinberg; George Q Daley
Epigenetic memory in induced pluripotent stem cells.
Nature 2010;467(7313):285-90.
2010: Lingyi Chen; Dekun Wang; Zhaoting Wu; Liping Ma; George Q Daley
Molecular basis of the first cell fate determination in mouse embryogenesis.
Cell research 2010;20(9):982-93.
2010: Odelya Hartung; Hongguang Huo; George Q Daley; Thorsten M Schlaeger
Clump passaging and expansion of human embryonic and induced pluripotent stem cells on mouse embryonic fibroblast feeder cells.
Current protocols in stem cell biology 2010;Chapter 1():Unit 1C.10.
2010: Michael G Kharas; Christopher J Lengner; Fatima Al-Shahrour; Lars Bullinger; Brian Ball; Samir Zaidi; Kelly Morgan; Winnie Tam; Mahnaz Paktinat; Rachel Okabe; Maricel Gozo; William Einhorn; Steven W Lane; Claudia Scholl; Stefan Fröhling; Mark Fleming; Benjamin L Ebert; D Gary Gilliland; Rudolf Jaenisch; George Q Daley
Musashi-2 regulates normal hematopoiesis and promotes aggressive myeloid leukemia.
Nature medicine 2010;16(8):903-8.
2010: Jill L O de Jong; Alan J Davidson; Yuan Wang; James Palis; Praise Opara; Emily Pugach; George Q Daley; Leonard I Zon
Interaction of retinoic acid and scl controls primitive blood development.
Blood 2010;116(2):201-9.
2010: Yuin-Han Loh; Odelya Hartung; Hu Li; Chunguang Guo; Julie M Sahalie; Philip D Manos; Achia Urbach; Garrett C Heffner; Marica Grskovic; Francois Vigneault; M William Lensch; In-Hyun Park; Suneet Agarwal; George M Church; James J Collins; Stefan Irion; George Q Daley
Reprogramming of T cells from human peripheral blood.
Cell stem cell 2010;7(1):15-9.
2010: Hao Zhu; Samar Shah; Ng Shyh-Chang; Gen Shinoda; William S Einhorn; Srinivas R Viswanathan; Ayumu Takeuchi; Corinna Grasemann; John L Rinn; Mary F Lopez; Joel N Hirschhorn; Mark R Palmert; George Q Daley
Lin28a transgenic mice manifest size and puberty phenotypes identified in human genetic association studies.
Nature genetics 2010;42(7):626-30.
2010: Dae-Sung Kim; Jae Souk Lee; Joong Woo Leem; Yong Jun Huh; Ji Young Kim; Han-Soo Kim; In-Hyun Park; George Q Daley; Dong-Youn Hwang; Dong-Wook Kim
Robust enhancement of neural differentiation from human ES and iPS cells regardless of their innate difference in differentiation propensity.
Stem cell reviews 2010;6(2):270-81.
2010: Achia Urbach; Ori Bar-Nur; George Q Daley; Nissim Benvenisty
Differential modeling of fragile X syndrome by human embryonic stem cells and induced pluripotent stem cells.
Cell stem cell 2010;6(5):407-11.
2010: Asmin Tulpule; M William Lensch; Justine D Miller; Karyn Austin; Alan D'Andrea; Thorsten M Schlaeger; Akiko Shimamura; George Q Daley
Knockdown of Fanconi anemia genes in human embryonic stem cells reveals early developmental defects in the hematopoietic lineage.
Blood 2010;115(17):3453-62.
2010: Suneet Agarwal; Yuin-Han Loh; Erin M McLoughlin; Junjiu Huang; In-Hyun Park; Justine D Miller; Hongguang Huo; Maja Okuka; Rosana Maria dos Reis; Sabine Loewer; Huck-Hui Ng; David L Keefe; Frederick D Goldman; Aloysius J Klingelhutz; Lin Liu; George Q Daley
Telomere elongation in induced pluripotent stem cells from dyskeratosis congenita patients.
Nature 2010;464(7286):292-6.
2010: Suneet Agarwal; George Q Daley
AID for reprogramming.
Cell research 2010;20(3):253-5.
2010: Srinivas R Viswanathan; George Q Daley
Lin28: A microRNA regulator with a macro role.
Cell 2010;140(4):445-9.
2010: Mohammad Azam; John T Powers; William Einhorn; Wei-Sheng Huang; William C Shakespeare; Xiaotian Zhu; David C Dalgarno; Tim Clackson; Tomi K Sawyer; George Q Daley
AP24163 inhibits the gatekeeper mutant of BCR-ABL and suppresses in vitro resistance.
Chemical biology & drug design 2010;75(2):223-7.
2010: Jianming Zhang; Francisco J Adrián; Wolfgang Jahnke; Sandra W Cowan-Jacob; Allen G Li; Roxana E Iacob; Taebo Sim; John Powers; Christine Dierks; Fangxian Sun; Gui-Rong Guo; Qiang Ding; Barun Okram; Yongmun Choi; Amy Wojciechowski; Xianming Deng; Guoxun Liu; Gabriele Fendrich; André Strauss; Navratna Vajpai; Stephan Grzesiek; Tove tuntland; Yi Liu; Badry Bursulaya; Mohammad Azam; Paul W Manley; John R Engen; George Q Daley; Markus Warmuth; Nathanael S Gray
Targeting Bcr-Abl by combining allosteric with ATP-binding-site inhibitors.
Nature 2010;463(7280):501-6.
2010: Steen Kt Ooi; Daniel Wolf; Odelya Hartung; Suneet Agarwal; George Q Daley; Stephen P Goff; Timothy H Bestor
Dynamic instability of genomic methylation patterns in pluripotent stem cells.
Epigenetics & chromatin 2010;3(1):17.
2010: Joshua R Mauney; Aruna Ramachandran; Richard N Yu; George Q Daley; Rosalyn M Adam; Carlos R Estrada
All-trans retinoic acid directs urothelial specification of murine embryonic stem cells via GATA4/6 signaling mechanisms.
PloS one 2010;5(7):e11513.
2010: George Q Daley
Stem cells: roadmap to the clinic.
The Journal of clinical investigation 2010;120(1):8-10.
2010: Claudia Lengerke; George Q Daley
Autologous blood cell therapies from pluripotent stem cells.
Blood reviews 2010;24(1):27-37.
2010: Gareth J Sullivan; David C Hay; In-Hyun Park; Judy Fletcher; Zara Hannoun; Catherine M Payne; Donna Dalgetty; James R Black; James A Ross; Kay Samuel; Gang Wang; George Q Daley; Je-Hyuk Lee; George M Church; Stuart J Forbes; John P Iredale; Ian Wilmut
Generation of functional human hepatic endoderm from human induced pluripotent stem cells.
Hepatology (Baltimore, Md.) 2010;51(1):329-35.
2009: Akiko Doi; In-Hyun Park; Bo Wen; Peter Murakami; Martin Aryee; Rafael A Irizarry; Brian Herb; Christine Ladd-Acosta; Junsung Rho; Sabine Loewer; Justine Miller; Thorsten Schlaeger; George Q Daley; Andrew P Feinberg
Differential methylation of tissue- and cancer-specific CpG island shores distinguishes human induced pluripotent stem cells, embryonic stem cells and fibroblasts.
Nature genetics 2009;41(12):1350-3.
2009: Je-Hyuk Lee; In-Hyun Park; Yuan Gao; Jin Billy Li; Zhe Li; George Q Daley; Kun Zhang; George M Church
A robust approach to identifying tissue-specific gene expression regulatory variants using personalized human induced pluripotent stem cells.
PLoS genetics 2009;5(11):e1000718.
2009: Elayne M Chan; Sutheera Ratanasirintrawoot; In-Hyun Park; Philip D Manos; Yuin-Han Loh; Hongguang Huo; Justine D Miller; Odelya Hartung; Junsung Rho; Tan Ince; George Q Daley; Thorsten M Schlaeger
Live cell imaging distinguishes bona fide human iPS cells from partially reprogrammed cells.
Nature biotechnology 2009;27(11):1033-7.
2009: Claudia Lengerke; Matthias Grauer; Nina I Niebuhr; Tamara Riedt; Lothar Kanz; In-Hyun Park; George Q Daley
Hematopoietic development from human induced pluripotent stem cells.
Annals of the New York Academy of Sciences 2009;1176():219-27.
2009: Claudia Lengerke; George Q Daley
Disease models from pluripotent stem cells.
Annals of the New York Academy of Sciences 2009;1176():191-6.
2009: Lingyi Chen; Akiko Yabuuchi; Sarah Eminli; Ayumu Takeuchi; Chi-Wei Lu; Konrad Hochedlinger; George Q Daley
Cross-regulation of the Nanog and Cdx2 promoters.
Cell research 2009;19(9):1052-61.
2009: Jason A West; Srinivas R Viswanathan; Akiko Yabuuchi; Kerianne Cunniff; Ayumu Takeuchi; In-Hyun Park; Julia E Sero; Hao Zhu; Antonio Perez-Atayde; Lindsay Frazier; M Azim Surani; George Q Daley
A role for Lin28 in primordial germ-cell development and germ-cell malignancy.
Nature 2009;460(7257):909-13.
2009: Wei-Sheng Huang; Xiaotian Zhu; Yihan Wang; Mohammad Azam; David Wen; Raji Sundaramoorthi; R Mathew Thomas; Shuangying Liu; Geetha Banda; Scott P Lentini; Sasmita Das; Qihong Xu; Jeffrey A Keats; Frank Wang; Scott Wardwell; Yaoyu Ning; Joseph T Snodgrass; Marc I Broudy; Karin Russian; George Q Daley; John D Iuliucci; David C Dalgarno; Tim Clackson; Tomi K Sawyer; William C Shakespeare
9-(Arenethenyl)purines as dual Src/Abl kinase inhibitors targeting the inactive conformation: design, synthesis, and biological evaluation.
Journal of medicinal chemistry 2009;52(15):4743-56.
2009: Olaia Naveiras; Valentina Nardi; Pamela L Wenzel; Peter V Hauschka; Frederic Fahey; George Q Daley
Bone-marrow adipocytes as negative regulators of the haematopoietic microenvironment.
Nature 2009;460(7252):259-63.
2009: Shannon L McKinney-Freeman; Olaia Naveiras; frank yates; Sabine Loewer; Marsha Philitas; Matthew Curran; Peter J Park; George Q Daley
Surface antigen phenotypes of hematopoietic stem cells from embryos and murine embryonic stem cells.
Blood 2009;114(2):268-78.
2009: Jizhong Zou; Morgan L Maeder; Prashant Mali; Shondra M Pruett-Miller; Stacey Thibodeau-Beganny; Bin-Kuan Chou; Guibin Chen; Zhaohui Ye; In-Hyun Park; George Q Daley; Matthew H Porteus; J Keith Joung; Linzhao Cheng
Gene targeting of a disease-related gene in human induced pluripotent stem and embryonic stem cells.
Cell stem cell 2009;5(1):97-110.
2009: Srinivas R Viswanathan; John T Powers; William Einhorn; Yujin Hoshida; Tony L Ng; Sara Toffanin; Maureen O'Sullivan; Jun Lu; Letha A Phillips; Victoria L Lockhart; Samar P Shah; Pradeep S Tanwar; Craig H Mermel; Rameen Beroukhim; Mohammad Azam; Jose Teixeira; Matthew Meyerson; Timothy P Hughes; Josep M Llovet; Jerald Radich; Charles G Mullighan; Todd R Golub; Poul H Sorensen; George Q Daley
Lin28 promotes transformation and is associated with advanced human malignancies.
Nature genetics 2009;41(7):843-8.
2009: Kwan-Hyuck Baek; Alexander Zaslavsky; Ryan C Lynch; Carmella Britt; Yoshiaki Okada; Richard J Siarey; M William Lensch; In-Hyun Park; Sam S Yoon; Takashi Minami; julie R korenberg; Judah Folkman; George Q Daley; William C Aird; Zygmunt Galdzicki; Sandra W Ryeom
Down's syndrome suppression of tumour growth and the role of the calcineurin inhibitor DSCR1.
Nature 2009;459(7250):1126-30.
2009: Luigi Adamo; Olaia Naveiras; Pamela L Wenzel; Shannon L McKinney-Freeman; Peter J Mack; Jorge Gracia-Sancho; Astrid Suchy-Dicey; Momoko Yoshimoto; M William Lensch; Mervin C Yoder; Guillermo García-Cardeña; George Q Daley
Biomechanical forces promote embryonic haematopoiesis.
Nature 2009;459(7250):1131-5.
2009: Lars U Mueller; George Q Daley; David A Williams
Upping the ante: recent advances in direct reprogramming.
Molecular therapy : the journal of the American Society of Gene Therapy 2009;17(6):947-53.
2009: Yuin-Han Loh; Suneet Agarwal; In-Hyun Park; Achia Urbach; Hongguang Huo; Garrett C Heffner; Kitai Kim; Justine D Miller; Kitwa Ng; George Q Daley
Generation of induced pluripotent stem cells from human blood.
Blood 2009;113(22):5476-9.
2009: Collene R Jeter; Mark Badeaux; Grace Choy; Dhyan Chandra; Lubna Patrawala; Can Liu; Tammy Calhoun-Davis; Holm Zaehres; George Q Daley; Ding "Dean" G. Tang
Functional evidence that the self-renewal gene NANOG regulates human tumor development.
Stem cells (Dayton, Ohio) 2009;27(5):993-1005.
2009: Valentina Nardi; Olaia Naveiras; Mohammad Azam; George Q Daley
ICSBP-mediated immune protection against BCR-ABL-induced leukemia requires the CCL6 and CCL9 chemokines.
Blood 2009;113(16):3813-20.
2009: Jie Deng; Robert Shoemaker; Bin Xie; Athurva Gore; Emily M LeProust; Jessica Antosiewicz-Bourget; Dieter Egli; Nimet Maherali; In-Hyun Park; Junying Yu; George Q Daley; Kevin Eggan; Konrad Hochedlinger; James Thomson; Wei Wang; Yuan Gao; Kun Zhang
Targeted bisulfite sequencing reveals changes in DNA methylation associated with nuclear reprogramming.
Nature biotechnology 2009;27(4):353-60.
2009: Madeleine P Ball; Jin Billy Li; Yuan Gao; Je-Hyuk Lee; Emily M LeProust; In-Hyun Park; Bin Xie; George Q Daley; George M Church
Targeted and genome-scale strategies reveal gene-body methylation signatures in human cells.
Nature biotechnology 2009;27(4):361-8.
2009: Wolfram Goessling; Trista E North; Sabine Loewer; Allegra M Lord; Sang Lee; Cristi L Stoick-Cooper; Gilbert Weidinger; Mark Puder; George Q Daley; Randall T Moon; Leonard I Zon
Genetic interaction of PGE2 and Wnt signaling regulates developmental specification of stem cells and regeneration.
Cell 2009;136(6):1136-47.
2009: George Q Daley; M William Lensch; Rudolf Jaenisch; Alex Meissner; Kathrin Plath; Shinya Yamanaka
Broader implications of defining standards for the pluripotency of iPSCs.
Cell stem cell 2009;4(3):200-1; author reply 202.
2009: Peter Geon Kim; George Q Daley
Application of induced pluripotent stem cells to hematologic disease.
Cytotherapy 2009;11(8):980-9.
2009: Srinivas R Viswanathan; Craig H Mermel; Jun Lu; Chi-Wei Lu; Todd R Golub; George Q Daley
microRNA expression during trophectoderm specification.
PloS one 2009;4(7):e6143.
2009: In-Hyun Park; George Q Daley
Human iPS cell derivation/reprogramming.
Current protocols in stem cell biology 2009;Chapter 4():Unit 4A.1.
2008: Ismail Ismailoglu; Gabriel Yeamans; George Q Daley; Rita C R Perlingeiro; Michael Kyba
Mesodermal patterning activity of SCL.
Experimental hematology 2008;36(12):1593-603.
2008: Rui Zhao; George Q Daley
From fibroblasts to iPS cells: induced pluripotency by defined factors.
Journal of cellular biochemistry 2008;105(4):949-55.
2008: Mohammad Azam; Markus A Seeliger; Nathanael S Gray; John Kuriyan; George Q Daley
Activation of tyrosine kinases by mutation of the gatekeeper threonine.
Nature structural & molecular biology 2008;15(10):1109-18.
2008: In-Hyun Park; Natasha Arora; Hongguang Huo; Nimet Maherali; Tim Ahfeldt; Akiko Shimamura; M William Lensch; Chad Cowan; Konrad Hochedlinger; George Q Daley
Disease-specific induced pluripotent stem cells.
Cell 2008;134(5):877-86.
2008: Elena Piskounova; Srinivas R Viswanathan; Maja Janas; Robert J LaPierre; George Q Daley; Piotr Sliz; Richard I Gregory
Determinants of microRNA processing inhibition by the developmentally regulated RNA-binding protein Lin28.
The Journal of biological chemistry 2008;283(31):21310-4.
2008: Chi-Wei Lu; Akiko Yabuuchi; Lingyi Chen; Srinivas Viswanathan; Kitai Kim; George Q Daley
Ras-MAPK signaling promotes trophectoderm formation from embryonic stem cells and mouse embryos.
Nature genetics 2008;40(7):921-6.
2008: Yuan Wang; Akiko Yabuuchi; Shannon L McKinney-Freeman; Danica M K Ducharme; Manas K Ray; Kallayanee Chawengsaksophak; Trevor K Archer; George Q Daley
Cdx gene deficiency compromises embryonic hematopoiesis in the mouse.
Proceedings of the National Academy of Sciences of the United States of America 2008;105(22):7756-61.
2008: Shannon L McKinney-Freeman; Claudia Lengerke; Il-Ho Jang; Sabine Schmitt; Yuan Wang; Marsha Philitas; Jessica Shea; George Q Daley
Modulation of murine embryonic stem cell-derived CD41+c-kit+ hematopoietic progenitors by ectopic expression of Cdx genes.
Blood 2008;111(10):4944-53.
2008: Lingyi Chen; George Q Daley
Molecular basis of pluripotency.
Human molecular genetics 2008;17(R1):R23-7.
2008: Srinivas R Viswanathan; George Q Daley; Richard I Gregory
Selective blockade of microRNA processing by Lin28.
Science (New York, N.Y.) 2008;320(5872):97-100.
2008: Elayne M Chan; frank yates; Leah F Boyer; Thorsten M Schlaeger; George Q Daley
Enhanced plating efficiency of trypsin-adapted human embryonic stem cells is reversible and independent of trisomy 12/17.
Cloning and stem cells 2008;10(1):107-18.
2008: George Q Daley; David T Scadden
Prospects for stem cell-based therapy.
Cell 2008;132(4):544-8.
2008: Shannon L McKinney-Freeman; Olaia Naveiras; George Q Daley
Isolation of hematopoietic stem cells from mouse embryonic stem cells.
Current protocols in stem cell biology 2008;Chapter 1():Unit 1F.3.
2008: Paul Lerou; Akiko Yabuuchi; Hongguang Huo; Ayumu Takeuchi; Jessica Shea; Tina Cimini; Tan Ince; Elizabeth S Ginsburg; Catherine Racowsky; George Q Daley
Human embryonic stem cell derivation from poor-quality embryos.
Nature biotechnology 2008;26(2):212-4.
2008: Valentina Nardi; T Raz; X Cao; Catherine J Wu; Richard M Stone; J Cortes; Michael W N Deininger; G Church; J Zhu; George Q Daley
Quantitative monitoring by polymerase colony assay of known mutations resistant to ABL kinase inhibitors.
Oncogene 2008;27(6):775-82.
2008: Claudia Lengerke; Sabine Schmitt; Teresa V Bowman; Il Ho Jang; Leila Maouche-Chretien; Shannon L McKinney-Freeman; Alan J Davidson; Matthias Hammerschmidt; Fabian Rentzsch; Jeremy B A Green; Leonard I Zon; George Q Daley
BMP and Wnt specify hematopoietic fate by activation of the Cdx-Hox pathway.
Cell stem cell 2008;2(1):72-82.
2008: In-Hyun Park; Rui Zhao; Jason A West; Akiko Yabuuchi; Hongguang Huo; Tan Ince; Paul Lerou; M William Lensch; George Q Daley
Reprogramming of human somatic cells to pluripotency with defined factors.
Nature 2008;451(7175):141-6.
2008: George Q Daley
Common themes of dedifferentiation in somatic cell reprogramming and cancer.
Cold Spring Harbor symposia on quantitative biology 2008;73():171-4.
2008: In-Hyun Park; Paul Lerou; Rui Zhao; Hongguang Huo; George Q Daley
Generation of human-induced pluripotent stem cells.
Nature protocols 2008;3(7):1180-6.
2008: Paul Lerou; Akiko Yabuuchi; Hongguang Huo; Justine D Miller; Leah F Boyer; Thorsten M Schlaeger; George Q Daley
Derivation and maintenance of human embryonic stem cells from poor-quality in vitro fertilization embryos.
Nature protocols 2008;3(5):923-33.
2007: Xiao Wu; M William Lensch; Jill Wylie-Sears; George Q Daley; Joyce Bischoff
Hemogenic endothelial progenitor cells isolated from human umbilical cord blood.
Stem cells (Dayton, Ohio) 2007;25(11):2770-6.
2007: Jorge Cortes; Elias Jabbour; George Q Daley; Susan O'Brien; Srdan Verstovsek; Alessandra Ferrajoli; Charles Koller; Yali Zhu; Paul Statkevich; Andrew Lamb
Phase 1 study of lonafarnib (SCH 66336) and imatinib mesylate in patients with chronic myeloid leukemia who have failed prior single-agent therapy with imatinib.
Cancer 2007;110(6):1295-302.
2007: Tal Raz; Valentina Nardi; Mohammad Azam; Jorge Cortes; George Q Daley
Farnesyl transferase inhibitor resistance probed by target mutagenesis.
Blood 2007;110(6):2102-9.
2007: Kitai Kim; Kitwa Ng; Peter J Rugg-Gunn; Jae-Hung Shieh; Oktay Kirak; Rudolf Jaenisch; Teruhiko Wakayama; Malcolm A S Moore; Roger A Pedersen; George Q Daley
Recombination signatures distinguish embryonic stem cells derived by parthenogenesis and somatic cell nuclear transfer.
Cell stem cell 2007;1(3):346-52.
2007: M William Lensch; Thorsten M Schlaeger; Leonard I Zon; George Q Daley
Teratoma formation assays with human embryonic stem cells: a rationale for one type of human-animal chimera.
Cell stem cell 2007;1(3):253-8.
2007: Suneet Agarwal; M William Lensch; George Q Daley
Current prospects for the generation of patient-specific pluripotent cells from adult tissues.
Regenerative medicine 2007;2(5):743-52.
2007: In-Hyun Park; George Q Daley
Debugging cellular reprogramming.
Nature cell biology 2007;9(8):871-3.
2007: M William Lensch; George Q Daley
Human embryonic stem cells flock together.
Nature biotechnology 2007;25(7):748-50.
2007: Shannon L McKinney-Freeman; George Q Daley
Towards hematopoietic reconstitution from embryonic stem cells: a sanguine future.
Current opinion in hematology 2007;14(4):343-7.
2007: Zhao Chen; Olaia Naveiras; Alessandra Balduini; Akiko Mammoto; Mary Anne Conti; Robert S Adelstein; Donald Ingber; George Q Daley; Ramesh A Shivdasani
The May-Hegglin anomaly gene MYH9 is a negative regulator of platelet biogenesis modulated by the Rho-ROCK pathway.
Blood 2007;110(1):171-9.
2007: Trista E North; Wolfram Goessling; Carl R Walkley; Claudia Lengerke; Kamden R Kopani; Allegra M Lord; Gerhard J Weber; Teresa V Bowman; Il-Ho Jang; Tilo Grosser; garret fitzgerald; George Q Daley; Stuart H Orkin; Leonard I Zon
Prostaglandin E2 regulates vertebrate haematopoietic stem cell homeostasis.
Nature 2007;447(7147):1007-11.
2007: Claudia Lengerke; Kitai Kim; Paul Lerou; George Q Daley
Differentiation potential of histocompatible parthenogenetic embryonic stem cells.
Annals of the New York Academy of Sciences 2007;1106():209-18.
2007: Claudia Lengerke; Shannon L McKinney-Freeman; Olaia Naveiras; frank yates; Yuan Wang; Dimple Bansal; George Q Daley
The cdx-hox pathway in hematopoietic stem cell formation from embryonic stem cells.
Annals of the New York Academy of Sciences 2007;1106():197-208.
2007: George Q Daley
Gametes from embryonic stem cells: a cup half empty or half full?
Science (New York, N.Y.) 2007;316(5823):409-10.
2007: George Q Daley; Lars Ahrlund-Richter; Jonathan M Auerbach; Nissim Benvenisty; R Alta Charo; Grace Chen; Hong-Kui Deng; Lawrence S Goldstein; Kathy Hudson; Insoo Hyun; Sung Chull Junn; Jane Love; Eng Hin Lee; Anne McLaren; Christine L Mummery; Norio Nakatsuji; Catherine Racowsky; Heather Rooke; Janet Rossant; Hans R Schöler; Jan Helge Solbakk; Patrick Taylor; Alan O Trounson; Irving L Weissman; Ian Wilmut; John Yu; Laurie Zoloth
Ethics. The ISSCR guidelines for human embryonic stem cell research.
Science (New York, N.Y.) 2007;315(5812):603-4.
2007: Kitai Kim; Paul Lerou; Akiko Yabuuchi; Claudia Lengerke; Kitwa Ng; Jason West; Andrew Kirby; Mark J Daly; George Q Daley
Histocompatible embryonic stem cells by parthenogenesis.
Science (New York, N.Y.) 2007;315(5811):482-6.
2007: George Q Daley
Towards the generation of patient-specific pluripotent stem cells for combined gene and cell therapy of hematologic disorders.
Hematology / the Education Program of the American Society of Hematology. American Society of Hematology. Education Program 2007;():17-22.
2006: Dimple Bansal; Claudia Scholl; Stefan Fröhling; Elizabeth P McDowell; Benjamin H Lee; Konstanze Döhner; Patricia Ernst; Alan J Davidson; George Q Daley; Leonard I Zon; D Gary Gilliland; Brian J P Huntly
Cdx4 dysregulates Hox gene expression and generates acute myeloid leukemia alone and in cooperation with Meis1a in a murine model.
Proceedings of the National Academy of Sciences of the United States of America 2006;103(45):16924-9.
2006: frank yates; George Q Daley
Progress and prospects: gene transfer into embryonic stem cells.
Gene therapy 2006;13(20):1431-9.
2006: Mohammad Azam; Valentina Nardi; William C Shakespeare; Chester A Metcalf; Regine S Bohacek; Yihan Wang; Raji Sundaramoorthi; Piotr Sliz; Darren R Veach; William G Bornmann; Bayard Clarkson; David C Dalgarno; Tomi K Sawyer; George Q Daley
Activity of dual SRC-ABL inhibitors highlights the role of BCR/ABL kinase dynamics in drug resistance.
Proceedings of the National Academy of Sciences of the United States of America 2006;103(24):9244-9.
2006: Stephen Willey; Angel Ayuso-Sacido; Hailan Zhang; Stuart T Fraser; Kenneth E Sahr; Matthew Adlam; Michael Kyba; George Q Daley; Gordon Keller; Margaret H Baron
Acceleration of mesoderm development and expansion of hematopoietic progenitors in differentiating ES cells by the mouse Mix-like homeodomain transcription factor.
Blood 2006;107(8):3122-30.
2006: Olaia Naveiras; George Q Daley
Stem cells and their niche: a matter of fate.
Cellular and molecular life sciences : CMLS 2006;63(7-8):760-6.
2006: M William Lensch; George Q Daley
Scientific and clinical opportunities for modeling blood disorders with embryonic stem cells.
Blood 2006;107(7):2605-12.
2006: Gautam Borthakur; Andrew Lamb; George Q Daley; Moshe Talpaz; Susan O'Brien; Guillermo Garcia-Manero; Francis Giles; Stefan Faderl; Mary Sugrue; Jorge Cortes
Pilot study of lonafarnib, a farnesyl transferase inhibitor, in patients with chronic myeloid leukemia in the chronic or accelerated phase that is resistant or refractory to imatinib therapy.
Cancer 2006;106(2):346-52.
2006: Jason A West; In-Hyun Park; George Q Daley; Niels Geijsen
In vitro generation of germ cells from murine embryonic stem cells.
Nature protocols 2006;1(4):2026-36.
2006: Holm Zaehres; George Q Daley
Transgene expression and RNA interference in embryonic stem cells.
Methods in enzymology 2006;420():49-64.
2006: Niels Geijsen; George Q Daley
Male germ cells.
Methods in enzymology 2006;418():307-14.
2006: Mohammad Azam; George Q Daley
Anticipating clinical resistance to target-directed agents : the BCR-ABL paradigm.
Molecular diagnosis & therapy 2006;10(2):67-76.
2005: Yuan Wang; frank yates; Olaia Naveiras; Patricia Ernst; George Q Daley
Embryonic stem cell-derived hematopoietic stem cells.
Proceedings of the National Academy of Sciences of the United States of America 2005;102(52):19081-6.
2005: Ruwanthi N Gunawardane; Dennis C Sgroi; Carolyn N Wrobel; Eugene Koh; George Q Daley; Joan S Brugge
Novel role for PDEF in epithelial cell migration and invasion.
Cancer research 2005;65(24):11572-80.
2005: Paul Lerou; George Q Daley
Therapeutic potential of embryonic stem cells.
Blood reviews 2005;19(6):321-31.
2005: Claudia Lengerke; George Q Daley
Patterning definitive hematopoietic stem cells from embryonic stem cells.
Experimental hematology 2005;33(9):971-9.
2005: George Q Daley
Customized human embryonic stem cells.
Nature biotechnology 2005;23(7):826-8.
2005: Atsushi Kubo; Vincent Chen; Marion Kennedy; Elizabeth Zahradka; George Q Daley; Gordon Keller
The homeobox gene HEX regulates proliferation and differentiation of hemangioblasts and endothelial cells during ES cell differentiation.
Blood 2005;105(12):4590-7.
2005: Kay Barnes; Elizabeth McIntosh; Anthony D Whetton; George Q Daley; Johanne Bentley; Stephen A Baldwin
Chronic myeloid leukaemia: an investigation into the role of Bcr-Abl-induced abnormalities in glucose transport regulation.
Oncogene 2005;24(20):3257-67.
2005: Holm Zaehres; M William Lensch; Laurence Daheron; Sheila A Stewart; Joseph Itskovitz-Eldor; George Q Daley
High-efficiency RNA interference in human embryonic stem cells.
Stem cells (Dayton, Ohio) 2005;23(3):299-305.
2005: Peter J Woolf; Wendy Prudhomme; Laurence Daheron; George Q Daley; Douglas A Lauffenburger
Bayesian analysis of signaling networks governing embryonic stem cell fate decisions.
Bioinformatics (Oxford, England) 2005;21(6):741-53.
2005: Ellen Weisberg; Paul W Manley; Werner Breitenstein; Josef Brüggen; Sandra W Cowan-Jacob; Arghya Ray; Brian J P Huntly; Doriano Fabbro; Gabriele Fendrich; Elizabeth Hall-Meyers; Andrew L Kung; Jürgen Mestan; George Q Daley; Linda Callahan; Laurence Catley; Cara Cavazza; Mohammad Azam; Azam Mohammed; Donna Neuberg; Renee D Wright; D Gary Gilliland; James D Griffin
Characterization of AMN107, a selective inhibitor of native and mutant Bcr-Abl.
Cancer cell 2005;7(2):129-41.
2005: George Q Daley; Michael J Sandel; Jonathan D Moreno
Stem cell research: science, ethics and policy.
Medical ethics (Burlington, Mass.) 2005;12(1):5.
2005: David T Ting; Michael Kyba; George Q Daley
Inducible transgene expression in mouse stem cells.
Methods in molecular medicine 2005;105():23-46.
2004: Douglas A Melton; George Q Daley; Charles G Jennings
Altered nuclear transfer in stem-cell research - a flawed proposal.
The New England journal of medicine 2004;351(27):2791-2.
2004: Jason A West; George Q Daley
In vitro gametogenesis from embryonic stem cells.
Current opinion in cell biology 2004;16(6):688-92.
2004: George Q Daley
Chronic myeloid leukemia: proving ground for cancer stem cells.
Cell 2004;119(3):314-6.
2004: George Q Daley
Missed opportunities in embryonic stem-cell research.
The New England journal of medicine 2004;351(7):627-8.
2004: George Q Daley
Alchemy in the liver: fact or fusion?
Nature medicine 2004;10(7):671-2.
2004: Stuart S Martin; Alan G Ridgeway; Jan Pinkas; Yu Lu; Mauricio J Reginato; Eugene Koh; Montserrat Michelman; George Q Daley; Joan S Brugge; Philip Leder
A cytoskeleton-based functional genetic screen identifies Bcl-xL as an enhancer of metastasis, but not primary tumor growth.
Oncogene 2004;23(26):4641-5.
2004: Evan Y Snyder; George Q Daley; Margaret Goodell
Taking stock and planning for the next decade: realistic prospects for stem cell therapies for the nervous system.
Journal of neuroscience research 2004;76(2):157-68.
2004: Wendy Prudhomme; George Q Daley; Peter Zandstra; Douglas A Lauffenburger
Multivariate proteomic analysis of murine embryonic stem cell self-renewal versus differentiation signaling.
Proceedings of the National Academy of Sciences of the United States of America 2004;101(9):2900-5.
2004: Eugene Koh; Tong Chen; George Q Daley
Genetic complementation of cytokine signaling identifies central role of kinases in hematopoietic cell proliferation.
Oncogene 2004;23(6):1214-20.
2004: Niels Geijsen; Melissa Horoschak; Kitai Kim; Joost Gribnau; Kevin Eggan; George Q Daley
Derivation of embryonic germ cells and male gametes from embryonic stem cells.
Nature 2004;427(6970):148-54.
2004: Laurence Dahéron; Sarah L Opitz; Holm Zaehres; M William Lensch; William M Lensch; Peter W Andrews; Joseph Itskovitz-Eldor; George Q Daley
LIF/STAT3 signaling fails to maintain self-renewal of human embryonic stem cells.
Stem cells (Dayton, Ohio) 2004;22(5):770-8.
2004: Konrad Hochedlinger; William M Rideout; Michael Kyba; George Q Daley; Robert Blelloch; Rudolf Jaenisch
Nuclear transplantation, embryonic stem cells and the potential for cell therapy.
The hematology journal : the official journal of the European Haematology Association / EHA 2004;5 Suppl 3():S114-7.
2004: M William Lensch; George Q Daley
Origins of mammalian hematopoiesis: in vivo paradigms and in vitro models.
Current topics in developmental biology 2004;60():127-96.
2004: Valentina Nardi; Mohammad Azam; George Q Daley
Mechanisms and implications of imatinib resistance mutations in BCR-ABL.
Current opinion in hematology 2004;11(1):35-43.
2003: Michael Kyba; George Q Daley
Hematopoiesis from embryonic stem cells: lessons from and for ontogeny.
Experimental hematology 2003;31(11):994-1006.
2003: Michael Kyba; Rita C R Perlingeiro; Russell R Hoover; Chi-Wei Lu; Jonathan Pierce; George Q Daley
Enhanced hematopoietic differentiation of embryonic stem cells conditionally expressing Stat5.
Proceedings of the National Academy of Sciences of the United States of America 2003;100 Suppl 1():11904-10.
2003: Alan J Davidson; Patricia Ernst; Yuan Wang; Marcus P S Dekens; Paul D Kingsley; James Palis; Stanley J Korsmeyer; George Q Daley; Leonard I Zon
cdx4 mutants fail to specify blood progenitors and can be rescued by multiple hox genes.
Nature 2003;425(6955):300-6.
2003: George Q Daley
Cloning and stem cells--handicapping the political and scientific debates.
The New England journal of medicine 2003;349(3):211-2.
2003: George Q Daley
ES cells prove egg-straordinary.
Nature biotechnology 2003;21(7):760-1.
2003: George Q Daley
From embryos to embryoid bodies: generating blood from embryonic stem cells.
Annals of the New York Academy of Sciences 2003;996():122-31.
2003: George Q Daley
Gleevec resistance: lessons for target-directed drug development.
Cell cycle (Georgetown, Tex.) 2003;2(3):190-1.
2003: George Q Daley
Towards combination target-directed chemotherapy for chronic myeloid leukemia: role of farnesyl transferase inhibitors.
Seminars in hematology 2003;40(2 Suppl 2):11-4.
2003: Mohammad Azam; Robert R Latek; George Q Daley
Mechanisms of autoinhibition and STI-571/imatinib resistance revealed by mutagenesis of BCR-ABL.
Cell 2003;112(6):831-43.
2003: Michael Kyba; Rita C R Perlingeiro; George Q Daley
Development of hematopoietic repopulating cells from embryonic stem cells.
Methods in enzymology 2003;365():114-29.
2003: George Q Daley; Margaret A Goodell; Evan Y Snyder
Realistic prospects for stem cell therapeutics.
Hematology / the Education Program of the American Society of Hematology. American Society of Hematology. Education Program 2003;():398-418.
2003: Rita C R Perlingeiro; Michael Kyba; Susan Bodie; George Q Daley
A role for thrombopoietin in hemangioblast development.
Stem cells (Dayton, Ohio) 2003;21(3):272-80.
2003: George Q Daley
Dodging the magic bullet: understanding imatinib resistance.
Cancer biology & therapy 2003;2(1):109-10.
2002: Eugene Koh; Tong Chen; George Q Daley
Novel retroviral vectors to facilitate expression screens in mammalian cells.
Nucleic acids research 2002;30(24):e142.
2002: George Q Daley
Prospects for stem cell therapeutics: myths and medicines.
Current opinion in genetics & development 2002;12(5):607-13.
2002: Russell R Hoover; Francois-Xavier Mahon; Junia V Melo; George Q Daley
Overcoming STI571 resistance with the farnesyl transferase inhibitor SCH66336.
Blood 2002;100(3):1068-71.
2002: Stephen M Dang; Michael Kyba; Rita C R Perlingeiro; George Q Daley; Peter W Zandstra
Efficiency of embryoid body formation and hematopoietic development from embryonic stem cells in different culture systems.
Biotechnology and bioengineering 2002;78(4):442-53.
2002: Michael Kyba; Rita C R Perlingeiro; George Q Daley
HoxB4 confers definitive lymphoid-myeloid engraftment potential on embryonic stem cell and yolk sac hematopoietic progenitors.
Cell 2002;109(1):29-37.
2002: William M Rideout; Konrad Hochedlinger; Michael Kyba; George Q Daley; Rudolf Jaenisch
Correction of a genetic defect by nuclear transplantation and combined cell and gene therapy.
Cell 2002;109(1):17-27.
2002: Avi Shvarts; Thijn R Brummelkamp; Ferenc Scheeren; Eugene Koh; George Q Daley; Hergen Spits; René Bernards
A senescence rescue screen identifies BCL6 as an inhibitor of anti-proliferative p19(ARF)-p53 signaling.
Genes & development 2002;16(6):681-6.
2002: Daniel S Peeper; Avi Shvarts; Thijn R Brummelkamp; Sirith Douma; Eugene Koh; George Q Daley; René Bernards
A functional screen identifies hDRIL1 as an oncogene that rescues RAS-induced senescence.
Nature cell biology 2002;4(2):148-53.
2002: Nilamani Jena; Ming Deng; Ewa Sicinska; Piotr Sicinski; George Q Daley
Critical role for cyclin D2 in BCR/ABL-induced proliferation of hematopoietic cells.
Cancer research 2002;62(2):535-41.
2001: Rita C R Perlingeiro; Michael Kyba; George Q Daley
Clonal analysis of differentiating embryonic stem cells reveals a hematopoietic progenitor with primitive erythroid and adult lymphoid-myeloid potential.
Development (Cambridge, England) 2001;128(22):4597-604.
2001: Russell R Hoover; Melissa Gerlach; Eugene Koh; George Q Daley
Cooperative and redundant effects of STAT5 and Ras signaling in BCR/ABL transformed hematopoietic cells.
Oncogene 2001;20(41):5826-35.
2001: M Deng; George Q Daley
Expression of interferon consensus sequence binding protein induces potent immunity against BCR/ABL-induced leukemia.
Blood 2001;97(11):3491-7.
2001: D G Peters; KM Klucher; Rita C R Perlingeiro; S K Dessain; Eugene Koh; George Q Daley
Autocrine and paracrine effects of an ES-cell derived, BCR/ABL-transformed hematopoietic cell line that induces leukemia in mice.
Oncogene 2001;20(21):2636-46.
2001: D G Peters; Russell R Hoover; Melissa Gerlach; Eugene Koh; H Zhang; K Choe; Paul Kirschmeier; W Robert Bishop; George Q Daley
Activity of the farnesyl protein transferase inhibitor SCH66336 against BCR/ABL-induced murine leukemia and primary cells from patients with chronic myeloid leukemia.
Blood 2001;97(5):1404-12.
2000: Jacqueline J L Jacobs; P Keblusek; Els C Robanus-Maandag; Petra M P Kristel; Merel Lingbeek; petra nederlof; Tibor van Welsem; Marc J van de Vijver; Eugene Koh; George Q Daley; Maarten van Lohuizen
Senescence bypass screen identifies TBX2, which represses Cdkn2a (p19(ARF)) and is amplified in a subset of human breast cancers.
Nature genetics 2000;26(3):291-9.
2000: Peter W Zandstra; H V Le; George Q Daley; L G Griffith; Douglas A Lauffenburger
Leukemia inhibitory factor (LIF) concentration modulates embryonic stem cell self-renewal and differentiation independently of proliferation.
Biotechnology and bioengineering 2000;69(6):607-17.
2000: Katrien Berns; E Marielle Hijmans; Eugene Koh; George Q Daley; René Bernards
A genetic screen to identify genes that rescue the slow growth phenotype of c-myc null fibroblasts.
Oncogene 2000;19(29):3330-4.
1999: Ravi Salgia; Elizabeth J Quackenbush; J Lin; N Souchkova; Martin Sattler; DS Ewaniuk; KM Klucher; George Q Daley; S K Kraeft; R Sackstein; Edwin P Alyea; Ulrich H von Andrian; Lan Bo Chen; Jose-Carlos Gutierrez-Ramos; A M Pendergast; James D Griffin
The BCR/ABL oncogene alters the chemotactic response to stromal-derived factor-1alpha.
Blood 1999;94(12):4233-46.
1999: Saghi Ghaffari; H Wu; Melissa Gerlach; Y Han; Harvey Lodish; George Q Daley
BCR-ABL and v-SRC tyrosine kinase oncoproteins support normal erythroid development in erythropoietin receptor-deficient progenitor cells.
Proceedings of the National Academy of Sciences of the United States of America 1999;96(23):13186-90.
1999: Saghi Ghaffari; George Q Daley; Harvey Lodish
Growth factor independence and BCR/ABL transformation: promise and pitfalls of murine model systems and assays.
Leukemia 1999;13(8):1200-6.
1999: S Li; RL Ilaria; Ryan P Million; George Q Daley; Richard A Van Etten
The P190, P210, and P230 forms of the BCR/ABL oncogene induce a similar chronic myeloid leukemia-like syndrome in mice but have different lymphoid leukemogenic activity.
The Journal of experimental medicine 1999;189(9):1399-412.
1998: Merav Socolovsky; Harvey Lodish; George Q Daley
Control of hematopoietic differentiation: lack of specificity in signaling by cytokine receptors.
Proceedings of the National Academy of Sciences of the United States of America 1998;95(12):6573-5.
1998: KM Klucher; D V Lopez; George Q Daley
Secondary mutation maintains the transformed state in BaF3 cells with inducible BCR/ABL expression.
Blood 1998;91(10):3927-34.
1998: Peter J Murray; R A Young; George Q Daley
Hematopoietic remodeling in interferon-gamma-deficient mice infected with mycobacteria.
Blood 1998;91(8):2914-24.
1997: KM Klucher; Melissa Gerlach; George Q Daley
A novel method to isolate cells with conditional gene expression using fluorescence activated cell sorting.
Nucleic acids research 1997;25(23):4858-60.
1994: George Q Daley
Genetic events in CML: from translocation to transplantation.
Bone marrow transplantation 1994;14 Suppl 3():S5-9.
1993: George Q Daley; J M Goldman
Autologous transplant for CML revisited.
Experimental hematology 1993;21(6):734-7.
1993: George Q Daley
Animal models of BCR/ABL-induced leukemias.
Leukemia & lymphoma 1993;11 Suppl 1():57-60.
1992: George Q Daley; Richard A Van Etten; P K Jackson; A Bernards; David Baltimore
Nonmyristoylated Abl proteins transform a factor-dependent hematopoietic cell line.
Molecular and cellular biology 1992;12(4):1864-71.
1991: George Q Daley; Richard A Van Etten; David Baltimore
Blast crisis in a murine model of chronic myelogenous leukemia.
Proceedings of the National Academy of Sciences of the United States of America 1991;88(24):11335-8.
1991: M L Scott; Richard A Van Etten; George Q Daley; David Baltimore
v-abl causes hematopoietic disease distinct from that caused by bcr-abl.
Proceedings of the National Academy of Sciences of the United States of America 1991;88(15):6506-10.
1991: George Q Daley; Y Ben-Neriah
Implicating the bcr/abl gene in the pathogenesis of Philadelphia chromosome-positive human leukemia.
Advances in cancer research 1991;57():151-84.
1990: George Q Daley; Richard A Van Etten; David Baltimore
Induction of chronic myelogenous leukemia in mice by the P210bcr/abl gene of the Philadelphia chromosome.
Science (New York, N.Y.) 1990;247(4944):824-30.
1988: George Q Daley; David Baltimore
Transformation of an interleukin 3-dependent hematopoietic cell line by the chronic myelogenous leukemia-specific P210bcr/abl protein.
Proceedings of the National Academy of Sciences of the United States of America 1988;85(23):9312-6.
1986: A M Mes-Masson; J McLaughlin; George Q Daley; M Paskind; O N Witte
Overlapping cDNA clones define the complete coding region for the P210c-abl gene product associated with chronic myelogenous leukemia cells containing the Philadelphia chromosome.
Proceedings of the National Academy of Sciences of the United States of America 1986;83(24):9768-72.
1986: Y Ben-Neriah; George Q Daley; A M Mes-Masson; O N Witte; David Baltimore
The chronic myelogenous leukemia-specific P210 protein is the product of the bcr/abl hybrid gene.
Science (New York, N.Y.) 1986;233(4760):212-4.
1986: Y Ben-Neriah; A Bernards; M Paskind; George Q Daley; David Baltimore
Alternative 5' exons in c-abl mRNA.
Cell 1986;44(4):577-86.