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Seth Alper

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Alicia Rivera; Robert Y L Zee; Seth L Alper; Luanne L Peters; Carlo Brugnara
Strain-specific variations in cation content and transport in mouse erythrocytes.
Boris E Shmukler; Oliver Andres; Stefan Eber; Sally Mukodzi; Seth L Alper
Autosomal dominant overhydrated stomatocytosis associated with the heterozygous RhAG mutation F65S: a case of missed heterozygosity due to allelic dropout.
Boris E Shmukler; David H Vandorpe; Jessica Alves; Ugo Bonfanti; Saverio Paltrinieri; Alicia Rivera; Seth L Alper
Cation-leak stomatocytosis in standard schnauzers does not cosegregate with coding mutations in the RhAG, SLC4A1, or GLUT1 genes associated with human disease.

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All Publications

2013: Alicia Rivera; Robert Y L Zee; Seth L Alper; Luanne L Peters; Carlo Brugnara
Strain-specific variations in cation content and transport in mouse erythrocytes.
Physiological genomics 2013;45(9):343-50.
2013: Boris E Shmukler; Oliver Andres; Stefan Eber; Sally Mukodzi; Seth L Alper
Autosomal dominant overhydrated stomatocytosis associated with the heterozygous RhAG mutation F65S: a case of missed heterozygosity due to allelic dropout.
British journal of haematology 2013;161(4):602-4.
2012: Boris E Shmukler; David H Vandorpe; Jessica Alves; Ugo Bonfanti; Saverio Paltrinieri; Alicia Rivera; Seth L Alper
Cation-leak stomatocytosis in standard schnauzers does not cosegregate with coding mutations in the RhAG, SLC4A1, or GLUT1 genes associated with human disease.
Blood cells, molecules & diseases 2012;48(4):219-25.
2011: Heather H Ward; Jing Wang; Seth L Alper; Edward J Bedrick; Ursa Brown-Glaberman; Dusanka Deretic; Vincent H Gattone; Yoshiko Morita; Angela Wandinger-Ness
A conserved signal and GTPase complex are required for the ciliary transport of polycystin-1.
Molecular biology of the cell 2011;22(18):3289-305.
2011: Andrew K Stewart; David H Vandorpe; Arash Akhavein; John F Heneghan; Hiroshi Ishiguro; Shigeru Ko; M Nakakuki; Fabian Reimold; Boris E Shmukler; Seth L Alper
SLC26 anion exchangers of guinea pig pancreatic duct: molecular cloning and functional characterization.
American journal of physiology. Cell physiology 2011;301(2):C289-303.
2011: Andrew K Stewart; Fouad T Chebib; Syed W Akbar; Maria J Salas; Rajan A Sonik; Boris E Shmukler; Seth L Alper
Interactions of mouse glycophorin A with the dRTA-related mutant G719D of the mouse Cl-/HCO3- exchanger Ae1.
Biochemistry and cell biology = Biochimie et biologie cellulaire 2011;89(2):224-35.
2011: Fabian R Reimold; Boris E Shmukler; Andrew K Stewart; David H Vandorpe; Israel Zelikovic; John F Heneghan; Seth L Alper
Pendrin function and regulation in Xenopus oocytes.
Cellular physiology and biochemistry : international journal of experimental cellular physiology, biochemistry, and pharmacology 2011;28(3):435-50.
2011: Alok K Sharma; Alan C Rigby; Seth L Alper
STAS domain structure and function.
Cellular physiology and biochemistry : international journal of experimental cellular physiology, biochemistry, and pharmacology 2011;28(3):407-22.
2010: John F Heneghan; Arash Akhavein; Maria J Salas; Boris E Shmukler; Lawrence P Karniski; David H Vandorpe; Seth L Alper
Regulated transport of sulfate and oxalate by SLC26A2/DTDST.
American journal of physiology. Cell physiology 2010;298(6):C1363-75.
2010: Andrew K Stewart; David H Vandorpe; John F Heneghan; Fouad Chebib; Kathleen Stolpe; Arash Akhavein; E Jennifer Edelman; Yelena Maksimova; Patrick G Gallagher; Seth L Alper
The GPA-dependent, spherostomatocytosis mutant AE1 E758K induces GPA-independent, endogenous cation transport in amphibian oocytes.
American journal of physiology. Cell physiology 2010;298(2):C283-97.
2010: David H Vandorpe; Chang Xu; Boris E Shmukler; Leo E Otterbein; Marie Trudel; Frederick Sachs; Philip A Gottlieb; Carlo Brugnara; Seth L Alper
Hypoxia activates a Ca2+-permeable cation conductance sensitive to carbon monoxide and to GsMTx-4 in human and mouse sickle erythrocytes.
PloS one 2010;5(1):e8732.
2009: Milan Bajmoczi; Mihaela Gadjeva; Seth L Alper; Gerald B Pier; David E Golan
Cystic fibrosis transmembrane conductance regulator and caveolin-1 regulate epithelial cell internalization of Pseudomonas aeruginosa.
American journal of physiology. Cell physiology 2009;297(2):C263-77.
2009: Alok K Sharma; Liwen Ye; Alexander S Zolotarev; Seth L Alper; Alan C Rigby
NMR assignment and secondary structure of the STAS domain of Rv1739c, a putative sulfate transporter of Mycobacterium tuberculosis.
Biomolecular NMR assignments 2009;3(1):99-102.
2009: Chang Xu; Boris E Shmukler; Katherine Nishimura; Elzbieta Kaczmarek; Sandro Rossetti; Peter C Harris; Angela Wandinger-Ness; Robert L Bacallao; Seth L Alper
Attenuated, flow-induced ATP release contributes to absence of flow-sensitive, purinergic Cai2+ signaling in human ADPKD cyst epithelial cells.
American journal of physiology. Renal physiology 2009;296(6):F1464-76.
2009: Sabina Casula; Alexander S Zolotarev; Alan K Stuart-Tilley; Sabine Wilhelm; Boris E Shmukler; Carlo Brugnara; Seth L Alper
Chemical crosslinking studies with the mouse Kcc1 K-Cl cotransporter.
Blood cells, molecules & diseases 2009;42(3):233-40.
2009: Andrew K Stewart; Christine E Kurschat; Richard D Vaughan-Jones; Seth L Alper
Putative re-entrant loop 1 of AE2 transmembrane domain has a major role in acute regulation of anion exchange by pH.
The Journal of biological chemistry 2009;284(10):6126-39.
2008: Seth L Alper; David H Vandorpe; Luanne L Peters; Carlo Brugnara
Reduced DIDS-sensitive chloride conductance in Ae1-/- mouse erythrocytes.
Blood cells, molecules & diseases 2008;41(1):22-34.
2008: Christine E Kurschat; Boris E Shmukler; Lianwei Jiang; Sarah Hevi; Edward H Kim; Andrew K Stewart; Seth L Alper
Mouse strain-specific coding polymorphism in the Slc4a2/Ae2 gene encodes Ae2c2 variants differing in isoform-specific dominant negative activity.
Experimental physiology 2008;93(4):458-67.
2008: Alexander S Zolotarev; Meera Unnikrishnan; Boris E Shmukler; Jeffrey S Clark; David H Vandorpe; Nikolaus Grigorieff; Eric J Rubin; Seth L Alper
Increased sulfate uptake by E. coli overexpressing the SLC26-related SulP protein Rv1739c from Mycobacterium tuberculosis.
Comparative biochemistry and physiology. Part A, Molecular & integrative physiology 2008;149(3):255-66.
2008: Jeffrey S Clark; David H Vandorpe; Marina N Chernova; John F Heneghan; Andrew K Stewart; Seth L Alper
Species differences in Cl- affinity and in electrogenicity of SLC26A6-mediated oxalate/Cl- exchange correlate with the distinct human and mouse susceptibilities to nephrolithiasis.
The Journal of physiology 2008;586(5):1291-306.
2008: Boris E Shmukler; Jeffrey S Clark; Ann Hsu; David H Vandorpe; Andrew K Stewart; Christine E Kurschat; Seong-Kyu Choe; Yi Zhou; Julio Amigo; Barry H Paw; Seth L Alper
Zebrafish ae2.2 encodes a second slc4a2 anion exchanger.
American journal of physiology. Regulatory, integrative and comparative physiology 2008;294(3):R1081-91.
2007: Andrew K Stewart; Christine E Kurschat; Richard D Vaughan-Jones; Boris E Shmukler; Seth L Alper
Acute regulation of mouse AE2 anion exchanger requires isoform-specific amino acid residues from most of the transmembrane domain.
The Journal of physiology 2007;584(Pt 1):59-73.
2007: Patricio E Morgan; Silvia Pastoreková; Alan K Stuart-Tilley; Seth L Alper; Joseph R Casey
Interactions of transmembrane carbonic anhydrase, CAIX, with bicarbonate transporters.
American journal of physiology. Cell physiology 2007;293(2):C738-48.
2007: Marco B Rust; Seth L Alper; York Rudhard; Boris E Shmukler; Rubén Vicente; Carlo Brugnara; Marie Trudel; Thomas J Jentsch; Christian A Hübner
Disruption of erythroid K-Cl cotransporters alters erythrocyte volume and partially rescues erythrocyte dehydration in SAD mice.
The Journal of clinical investigation 2007;117(6):1708-17.
2007: A K Stewart; C E Kurschat; Seth L Alper
Role of nonconserved charged residues of the AE2 transmembrane domain in regulation of anion exchange by pH.
Pflügers Archiv : European journal of physiology 2007;454(3):373-84.
2007: Paul A Stehberger; Boris E Shmukler; Alan K Stuart-Tilley; Luanne L Peters; Seth L Alper; Carsten A Wagner
Distal renal tubular acidosis in mice lacking the AE1 (band3) Cl-/HCO3- exchanger (slc4a1).
Journal of the American Society of Nephrology : JASN 2007;18(5):1408-18.
2007: Ahmad Akel; Carsten A Wagner; Jana Kovacikova; Ravi S Kasinathan; Valentin Kiedaisch; Saisudha Koka; Seth L Alper; Ingolf Bernhardt; Thomas Wieder; Stephan M Huber; Florian Lang
Enhanced suicidal death of erythrocytes from gene-targeted mice lacking the Cl-/HCO(3)(-) exchanger AE1.
American journal of physiology. Cell physiology 2007;292(5):C1759-67.
2007: adel malek; Chang Xu; Edward S Kim; Seth L Alper
Hypertonicity triggers RhoA-dependent assembly of myosin-containing striated polygonal actin networks in endothelial cells.
American journal of physiology. Cell physiology 2007;292(5):C1645-59.
2007: Chang Xu; Sandro Rossetti; Lianwei Jiang; Peter C Harris; Ursa Brown-Glaberman; Angela Wandinger-Ness; Robert L Bacallao; Seth L Alper
Human ADPKD primary cyst epithelial cells with a novel, single codon deletion in the PKD1 gene exhibit defective ciliary polycystin localization and loss of flow-induced Ca2+ signaling.
American journal of physiology. Renal physiology 2007;292(3):F930-45.
2007: Andrew K Stewart; Christine E Kurschat; D Burns; N Banger; Richard D Vaughan-Jones; Seth L Alper
Transmembrane domain histidines contribute to regulation of AE2-mediated anion exchange by pH.
American journal of physiology. Cell physiology 2007;292(2):C909-18.
2006: Christine E Kurschat; Boris E Shmukler; Lianwei Jiang; Sabine Wilhelm; Edward H Kim; Marina N Chernova; Rolf Kinne; Andrew K Stewart; Seth L Alper
Alkaline-shifted pHo sensitivity of AE2c1-mediated anion exchange reveals novel regulatory determinants in the AE2 N-terminal cytoplasmic domain.
The Journal of biological chemistry 2006;281(4):1885-96.
2006: Seth L Alper; Andrew K Stewart; Marina N Chernova; Alexander S Zolotarev; Jeffrey S Clark; David H Vandorpe
Anion exchangers in flux: functional differences between human and mouse SLC26A6 polypeptides.
Novartis Foundation symposium 2006;273():107-19; discussion 119-25, 261-4.
2006: Seth L Alper
Molecular physiology of SLC4 anion exchangers.
Experimental physiology 2006;91(1):153-61.
2005: Marina N Chernova; David H Vandorpe; Jeffrey S Clark; Jon I Williams; Michael Zasloff; Lianwei Jiang; Seth L Alper
Apparent receptor-mediated activation of Ca2+-dependent conductive Cl- transport by shark-derived polyaminosterols.
American journal of physiology. Regulatory, integrative and comparative physiology 2005;289(6):R1644-58.
2005: Boris E Shmukler; Christine E Kurschat; Gabriele E Ackermann; Lianwei Jiang; Yi Zhou; Bruce Barut; Alan K Stuart-Tilley; Jinhua Zhao; Leonard I Zon; Iain A Drummond; David H Vandorpe; Barry H Paw; Seth L Alper
Zebrafish slc4a2/ae2 anion exchanger: cDNA cloning, mapping, functional characterization, and localization.
American journal of physiology. Renal physiology 2005;289(4):F835-49.
2005: Marina N Chernova; David H Vandorpe; Jeffrey S Clark; Seth L Alper
Expression of the polycystin-1 C-terminal cytoplasmic tail increases Cl channel activity in Xenopus oocytes.
Kidney international 2005;68(2):632-41.
2005: Teresa Sherman; Marina N Chernova; Jeffrey S Clark; Lianwei Jiang; Seth L Alper; Keith Nehrke
The abts and sulp families of anion transporters from Caenorhabditis elegans.
American journal of physiology. Cell physiology 2005;289(2):C341-51.
2005: Marina N Chernova; Lianwei Jiang; David J Friedman; Rachel B Darman; Hannes Lohi; Juha Kere; David H Vandorpe; Seth L Alper
Functional comparison of mouse slc26a6 anion exchanger with human SLC26A6 polypeptide variants: differences in anion selectivity, regulation, and electrogenicity.
The Journal of biological chemistry 2005;280(9):8564-80.
2004: Sarah L Davies; Eleni Roussa; Philippe Le Rouzic; Frank Thévenod; Seth L Alper; Leonard Best; Peter D Brown
Expression of K+-Cl- cotransporters in the alpha-cells of rat endocrine pancreas.
Biochimica et biophysica acta 2004;1667(1):7-14.
2004: Paul A Rufo; Patricia W Lin; Adriana S A Andrade; Lianwei Jiang; Lucia E Rameh; Charles Flexner; Seth L Alper; Wayne I Lencer
Diarrhea-associated HIV-1 APIs potentiate muscarinic activation of Cl- secretion by T84 cells via prolongation of cytosolic Ca2+ signaling.
American journal of physiology. Cell physiology 2004;286(5):C998-C1008.
2004: Chairat Shayakul; Seth L Alper
Defects in processing and trafficking of the AE1 Cl-/HCO3- exchanger associated with inherited distal renal tubular acidosis.
Clinical and experimental nephrology 2004;8(1):1-11.
2004: Chairat Shayakul; Petr Jarolim; Marie Zachlederova; Daniel Prabakaran; Dionisio Cortez-Campeao; Dana Kalabova; Alan K Stuart-Tilley; Hiroshi Ideguchi; Christlieb Haller; Seth L Alper
Characterization of a highly polymorphic marker adjacent to the SLC4A1 gene and of kidney immunostaining in a family with distal renal tubular acidosis.
Nephrology, dialysis, transplantation : official publication of the European Dialysis and Transplant Association - European Renal Association 2004;19(2):371-9.
2003: Neera K Dahl; Lianwei Jiang; Marina N Chernova; Alan K Stuart-Tilley; Boris E Shmukler; Seth L Alper
Deficient HCO3- transport in an AE1 mutant with normal Cl- transport can be rescued by carbonic anhydrase II presented on an adjacent AE1 protomer.
The Journal of biological chemistry 2003;278(45):44949-58.
2003: Marina N Chernova; Lianwei Jiang; Boris E Shmukler; Clifford W Schweinfest; Paola G Blanco; Steven D Freedman; Andrew K Stewart; Seth L Alper
Acute regulation of the SLC26A3 congenital chloride diarrhoea anion exchanger (DRA) expressed in Xenopus oocytes.
The Journal of physiology 2003;549(Pt 1):3-19.
2003: Barry H Paw; Alan J Davidson; Yi Zhou; Rong Li; Stephen J Pratt; Charles Lee; Nikolaus S Trede; Alison Brownlie; Adriana Donovan; Eric C Liao; James M Ziai; Anna H Drejer; Wen Guo; Carol H Kim; Babette Gwynn; Luanne L Peters; Marina N Chernova; Seth L Alper; Agustín Zapata; Sunitha N Wickramasinghe; Matthew J Lee; Samuel E Lux; Andreas Fritz; John H Postlethwait; Leonard I Zon
Cell-specific mitotic defect and dyserythropoiesis associated with erythroid band 3 deficiency.
Nature genetics 2003;34(1):59-64.
2003: Marina N Chernova; Andrew K Stewart; Lianwei Jiang; David J Friedman; Yune Z Kunes; Seth L Alper
Structure-function relationships of AE2 regulation by Ca(i)(2+)-sensitive stimulators NH(4+) and hypertonicity.
American journal of physiology. Cell physiology 2003;284(5):C1235-46.
2002: Andrew K Stewart; Marina N Chernova; Boris E Shmukler; Sabine Wilhelm; Seth L Alper
Regulation of AE2-mediated Cl- transport by intracellular or by extracellular pH requires highly conserved amino acid residues of the AE2 NH2-terminal cytoplasmic domain.
The Journal of general physiology 2002;120(5):707-22.
2002: Eleni Roussa; Boris E Shmukler; Sabine Wilhelm; Sabina Casula; Alan K Stuart-Tilley; Frank Thévenod; Seth L Alper
Immunolocalization of potassium-chloride cotransporter polypeptides in rat exocrine glands.
Histochemistry and cell biology 2002;117(4):335-44.
2002: Seth L Alper; Rachel B Darman; Marina N Chernova; Neera K Dahl
The AE gene family of Cl/HCO3- exchangers.
Journal of nephrology 2002;15 Suppl 5():S41-53.
2002: David H Vandorpe; Sabine Wilhelm; Lianwei Jiang; Oxana Ibraghimov-Beskrovnaya; Marina N Chernova; Alan K Stuart-Tilley; Seth L Alper
Cation channel regulation by COOH-terminal cytoplasmic tail of polycystin-1: mutational and functional analysis.
Physiological genomics 2002;8(2):87-98.
2002: Seth L Alper; Marina N Chernova; Andrew K Stewart
How pH regulates a pH regulator: a regulatory hot spot in the N-terminal cytoplasmic domain of the AE2 anion exchanger.
Cell biochemistry and biophysics 2002;36(2-3):123-36.
2002: Seth L Alper
Genetic diseases of acid-base transporters.
Annual review of physiology 2002;64():899-923.
2001: Greg G Goss; Lianwei Jiang; David H Vandorpe; Dawn M Kieller; Marina N Chernova; Murray Robertson; Seth L Alper
Role of JNK in hypertonic activation of Cl(-)-dependent Na(+)/H(+) exchange in Xenopus oocytes.
American journal of physiology. Cell physiology 2001;281(6):C1978-90.
2001: Sabina Casula; Boris E Shmukler; Sabine Wilhelm; Alan K Stuart-Tilley; W Su; Marina N Chernova; Carlo Brugnara; Seth L Alper
A dominant negative mutant of the KCC1 K-Cl cotransporter: both N- and C-terminal cytoplasmic domains are required for K-Cl cotransport activity.
The Journal of biological chemistry 2001;276(45):41870-8.
2001: Andrew K Stewart; Marina N Chernova; Yune Z Kunes; Seth L Alper
Regulation of AE2 anion exchanger by intracellular pH: critical regions of the NH(2)-terminal cytoplasmic domain.
American journal of physiology. Cell physiology 2001;281(4):C1344-54.
2001: Heidi Rossmann; Oliver Bachmann; Z Wang; Gary E Shull; B Obermaier; Alan K Stuart-Tilley; Seth L Alper; Ursula Seidler
Differential expression and regulation of AE2 anion exchanger subtypes in rabbit parietal and mucous cells.
The Journal of physiology 2001;534(Pt 3):837-48.
2001: Seth L Alper; Marina N Chernova; Andrew K Stewart
Regulation of Na+-independent Cl-/HCO3- exchangers by pH.
JOP : Journal of the pancreas 2001;2(4 Suppl):171-5.
2001: Eleni Roussa; Seth L Alper; Frank Thévenod
Immunolocalization of anion exchanger AE2, Na(+)/H(+) exchangers NHE1 and NHE4, and vacuolar type H(+)-ATPase in rat pancreas.
The journal of histochemistry and cytochemistry : official journal of the Histochemistry Society 2001;49(4):463-74.
2001: Boris E Shmukler; Chris T Bond; Sabine Wilhelm; Andrew Bruening-Wright; James Maylie; John P Adelman; Seth L Alper
Structure and complex transcription pattern of the mouse SK1 K(Ca) channel gene, KCNN1.
Biochimica et biophysica acta 2001;1518(1-2):36-46.
2001: Panos Papageorgiou; Boris E Shmukler; Alan K Stuart-Tilley; Lianwei Jiang; Seth L Alper
AE anion exchangers in atrial tumor cells.
American journal of physiology. Heart and circulatory physiology 2001;280(3):H937-45.
2001: David H Vandorpe; Marina N Chernova; Lianwei Jiang; Lorenz Sellin; Sabine Wilhelm; Alan K Stuart-Tilley; Gerd Walz; Seth L Alper
The cytoplasmic C-terminal fragment of polycystin-1 regulates a Ca2+-permeable cation channel.
The Journal of biological chemistry 2001;276(6):4093-101.
2000: Chairat Shayakul; Seth L Alper
Inherited renal tubular acidosis.
Current opinion in nephrology and hypertension 2000;9(5):541-6.
2000: Boris E Shmukler; Carlo Brugnara; Seth L Alper
Structure and genetic polymorphism of the mouse KCC1 gene.
Biochimica et biophysica acta 2000;1492(2-3):353-61.
2000: Boris E Shmukler; Sabine Wilhelm; Seth L Alper
Short sequence repeat polymorphism in the mouse slc4al gene encoding the AE1 Cl-/HCO3-exchanger.
DNA sequence : the journal of DNA sequencing and mapping 2000;11(5):447-50.
2000: Heidi Rossmann; Seth L Alper; M Nader; Z Wang; Michael Gregor; Ursula Seidler
Three 5'-variant mRNAs of anion exchanger AE2 in stomach and intestine of mouse, rabbit, and rat.
Annals of the New York Academy of Sciences 2000;915():81-91.
1999: Eleni Roussa; Michael F Romero; Bernhard M Schmitt; Walter F Boron; Seth L Alper; Frank Thévenod
Immunolocalization of anion exchanger AE2 and Na(+)-HCO(-)(3) cotransporter in rat parotid and submandibular glands.
The American journal of physiology 1999;277(6 Pt 1):G1288-96.
1999: W Su; Boris E Shmukler; Marina N Chernova; Alan K Stuart-Tilley; L de Franceschi; Carlo Brugnara; Seth L Alper
Mouse K-Cl cotransporter KCC1: cloning, mapping, pathological expression, and functional regulation.
The American journal of physiology 1999;277(5 Pt 1):C899-912.
1999: Lars Jørn Jensen; Alan K Stuart-Tilley; Luanne L Peters; Samuel E Lux; Seth L Alper; Sylvie Breton
Immunolocalization of AE2 anion exchanger in rat and mouse epididymis.
Biology of reproduction 1999;61(4):973-80.
1999: Seth L Alper; Heidi Rossmann; Sabine Wilhelm; Alan K Stuart-Tilley; Boris E Shmukler; Ursula Seidler
Expression of AE2 anion exchanger in mouse intestine.
The American journal of physiology 1999;277(2 Pt 1):G321-32.
1999: Chairat Shayakul; Sylvie Breton; Dennis Brown; Seth L Alper
Gene therapy of inherited renal tubular disease.
American journal of kidney diseases : the official journal of the National Kidney Foundation 1999;34(2):374-9.
1999: A S Zolotarev; Boris E Shmukler; Seth L Alper
AE2 anion exchanger polypeptide is a homooligomer in pig gastric membranes: a chemical cross-linking study.
Biochemistry 1999;38(26):8521-31.
1999: adel malek; J Zhang; J Jiang; Seth L Alper; S Izumo
Endothelin-1 gene suppression by shear stress: pharmacological evaluation of the role of tyrosine kinase, intracellular calcium, cytoskeleton, and mechanosensitive channels.
Journal of molecular and cellular cardiology 1999;31(2):387-99.
1999: adel malek; L Jiang; I Lee; W C Sessa; S Izumo; Seth L Alper
Induction of nitric oxide synthase mRNA by shear stress requires intracellular calcium and G-protein signals and is modulated by PI 3 kinase.
Biochemical and biophysical research communications 1999;254(1):231-42.
1998: Voravarn S Tanphaichitr; Achra Sumboonnanonda; Hiroshi Ideguchi; Chairat Shayakul; Carlo Brugnara; M Takao; Gavivann Veerakul; Seth L Alper
Novel AE1 mutations in recessive distal renal tubular acidosis. Loss-of-function is rescued by glycophorin A.
The Journal of clinical investigation 1998;102(12):2173-9.
1998: David H Vandorpe; Boris E Shmukler; Lianwei Jiang; B Lim; James Maylie; John P Adelman; L de Franceschi; M D Cappellini; Carlo Brugnara; Seth L Alper
cDNA cloning and functional characterization of the mouse Ca2+-gated K+ channel, mIK1. Roles in regulatory volume decrease and erythroid differentiation.
The Journal of biological chemistry 1998;273(34):21542-53.
1998: Motohisa Tofukuji; Caroline Metais; S Y Wang; Seth L Alper; Frank W Sellke
Clotrimazole is a potent vasodilator of the rat coronary microcirculation.
The Journal of surgical research 1998;77(1):6-10.
1998: Alan K Stuart-Tilley; Boris E Shmukler; D Brown; Seth L Alper
Immunolocalization and tissue-specific splicing of AE2 anion exchanger in mouse kidney.
Journal of the American Society of Nephrology : JASN 1998;9(6):946-59.
1998: Petr Jarolim; Chairat Shayakul; D Prabakaran; L Jiang; Alan K Stuart-Tilley; HL Rubin; S Simova; Jiri Zavadil; J T Herrin; J Brouillette; M J Somers; E Seemanova; Carlo Brugnara; Lisa M Guay-Woodford; Seth L Alper
Autosomal dominant distal renal tubular acidosis is associated in three families with heterozygosity for the R589H mutation in the AE1 (band 3) Cl-/HCO3- exchanger.
The Journal of biological chemistry 1998;273(11):6380-8.
1997: Paul A Rufo; D Merlin; M Riegler; M H Ferguson-Maltzman; Bonny L Dickinson; Carlo Brugnara; Seth L Alper; Wayne I Lencer
The antifungal antibiotic, clotrimazole, inhibits chloride secretion by human intestinal T84 cells via blockade of distinct basolateral K+ conductances. Demonstration of efficacy in intact rabbit colon and in an in vivo mouse model of cholera.
The Journal of clinical investigation 1997;100(12):3111-20.
1997: Frank C Brosius III; R L Pisoni; X Cao; G Deshmukh; D Yannoukakos; Alan K Stuart-Tilley; Christlieb Haller; Seth L Alper
AE anion exchanger mRNA and protein expression in vascular smooth muscle cells, aorta, and renal microvessels.
The American journal of physiology 1997;273(6 Pt 2):F1039-47.
1997: adel malek; I W Lee; Seth L Alper; S Izumo
Regulation of endothelin-1 gene expression by cell shape and the microfilament network in vascular endothelium.
The American journal of physiology 1997;273(5 Pt 1):C1764-74.
1997: Marina N Chernova; Benjamin D Humphreys; D H Robinson; Alan K Stuart-Tilley; A M Garcia; Frank C Brosius III; Seth L Alper
Functional consequences of mutations in the transmembrane domain and the carboxy-terminus of the murine AE1 anion exchanger.
Biochimica et biophysica acta 1997;1329(1):111-23.
1997: Seth L Alper; Alan K Stuart-Tilley; D Biemesderfer; Boris E Shmukler; D Brown
Immunolocalization of AE2 anion exchanger in rat kidney.
The American journal of physiology 1997;273(4 Pt 2):F601-14.
1997: A R Rittenhouse; C Parker; Carlo Brugnara; Kathleen G Morgan; Seth L Alper
Inhibition of maxi-K currents in ferret portal vein smooth muscle cells by the antifungal clotrimazole.
The American journal of physiology 1997;273(1 Pt 1):C45-56.
1997: adel malek; S Izumo; Seth L Alper
Quantitative densitometric analysis using a commercially available handheld CCD digital camera.
BioTechniques 1997;22(6):1150-3.
1997: A R Rittenhouse; David H Vandorpe; Carlo Brugnara; Seth L Alper
The antifungal imidazole clotrimazole and its major in vivo metabolite are potent blockers of the calcium-activated potassium channel in murine erythroleukemia cells.
The Journal of membrane biology 1997;157(2):177-91.
1997: Benjamin D Humphreys; Marina N Chernova; L Jiang; Y Zhang; Seth L Alper
NH4Cl activates AE2 anion exchanger in Xenopus oocytes at acidic pHi.
The American journal of physiology 1997;272(4 Pt 1):C1232-40.
1997: Marina N Chernova; Lianwei Jiang; Marcel Crest; M Hand; David H Vandorpe; Kevin Strange; Seth L Alper
Electrogenic sulfate/chloride exchange in Xenopus oocytes mediated by murine AE1 E699Q.
The Journal of general physiology 1997;109(3):345-60.
1997: Boris E Shmukler; T Sun; Carlo Brugnara; Seth L Alper
Reinterpretation of the RACTK1 K+ channel.
The American journal of physiology 1997;272(1 Pt 1):C350-4.
1997: L Jiang; Marina N Chernova; Seth L Alper
Secondary regulatory volume increase conferred on Xenopus oocytes by expression of AE2 anion exchanger.
The American journal of physiology 1997;272(1 Pt 1):C191-202.
1996: Paul A Rufo; L Jiang; S J Moe; Carlo Brugnara; Seth L Alper; Wayne I Lencer
The antifungal antibiotic, clotrimazole, inhibits Cl- secretion by polarized monolayers of human colonic epithelial cells.
The Journal of clinical investigation 1996;98(9):2066-75.
1996: A S Zolotarev; Marina N Chernova; D Yannoukakos; Seth L Alper
Proteolytic cleavage sites of native AE2 anion exchanger in gastric mucosal membranes.
Biochemistry 1996;35(32):10367-76.
1996: A S Zolotarev; R R Townsend; Alan K Stuart-Tilley; Seth L Alper
HCO3(-)-dependent conformational change in gastric parietal cell AE2, a glycoprotein naturally lacking sialic acid.
The American journal of physiology 1996;271(2 Pt 1):G311-21.
1996: Jason Simon; G Deshmukh; Fergus J. Couch; Sofia D Merajver; Barbara L Weber; Pascale Van Vooren; F Tissil; Josiane Szpirer; Claude Szpirer; Seth L Alper; Howard J Jacob; Frank C Brosius III
Chromosomal mapping of the rat Slc4a family of anion exchanger genes, Ae1, Ae2, and Ae3.
Mammalian genome : official journal of the International Mammalian Genome Society 1996;7(5):380-2.
1996: Y Zhang; Marina N Chernova; Alan K Stuart-Tilley; Lianwei Jiang; Seth L Alper
The cytoplasmic and transmembrane domains of AE2 both contribute to regulation of anion exchange by pH.
The Journal of biological chemistry 1996;271(10):5741-9.
1996: C C Armsby; Alan K Stuart-Tilley; Seth L Alper; Carlo Brugnara
Resistance to osmotic lysis in BXD-31 mouse erythrocytes: association with upregulated K-Cl cotransport.
The American journal of physiology 1996;270(3 Pt 1):C866-77.
1996: Carlo Brugnara; Beatrice Gee; C C Armsby; S Kurth; Masayuki Sakamoto; Nader Rifai; Seth L Alper; O S Platt
Therapy with oral clotrimazole induces inhibition of the Gardos channel and reduction of erythrocyte dehydration in patients with sickle cell disease.
The Journal of clinical investigation 1996;97(5):1227-34.
1996: Lucia De Franceschi; Philippe Rouyer-Fessard; Seth L Alper; Hélène Jouault; Carlo Brugnara; Yves Beuzard
Combination therapy of erythropoietin, hydroxyurea, and clotrimazole in a beta thalassemic mouse: a model for human therapy.
Blood 1996;87(3):1188-95.
1996: I Coupry; C C Armsby; Seth L Alper; Carlo Brugnara; angelo parini
Clotrimazole and efaroxan inhibit red cell Gardos channel independently of imidazoline I1 and I2 binding sites.
European journal of pharmacology 1996;295(1):109-12.
1995: Sylvie Breton; Seth L Alper; S L Gluck; W S Sly; J E Barker; Dennis Brown
Depletion of intercalated cells from collecting ducts of carbonic anhydrase II-deficient (CAR2 null) mice.
The American journal of physiology 1995;269(6 Pt 2):F761-74.
1995: Marina N Chernova; Petr Jarolim; J Palek; Seth L Alper
Overexpression of AE1 Prague, but not of AE1 SAO, inhibits wild-type AE1 trafficking in Xenopus oocytes.
The Journal of membrane biology 1995;148(2):203-10.
1995: Frank C Brosius III; K Nguyen; Alan K Stuart-Tilley; C Haller; Josephine Briggs; Seth L Alper
Regional and segmental localization of AE2 anion exchanger mRNA and protein in rat kidney.
The American journal of physiology 1995;269(4 Pt 2):F461-8.
1995: Carlo Brugnara; C C Armsby; Lucia De Franceschi; Marcel Crest; M F Euclaire; Seth L Alper
Ca(2+)-activated K+ channels of human and rabbit erythrocytes display distinctive patterns of inhibition by venom peptide toxins.
The Journal of membrane biology 1995;147(1):71-82.
1995: I Coupry; C C Armsby; Seth L Alper; angelo parini; Carlo Brugnara
Inhibition of red cell Ca(2+)-activated K+ transport by clotrimazole does not take place via imidazoline binding sites.
Annals of the New York Academy of Sciences 1995;763():287-9.
1995: Carlo Brugnara; Lucia De Franceschi; C C Armsby; N Saadane; Marie Trudel; Yves Beuzard; A Rittenhouse; Nader Rifai; O Platt; Seth L Alper
A new therapeutic approach for sickle cell disease. Blockade of the red cell Ca(2+)-activated K+ channel by clotrimazole.
Annals of the New York Academy of Sciences 1995;763():262-71.
1995: C C Armsby; Carlo Brugnara; Seth L Alper
Cation transport in mouse erythrocytes: role of K(+)-Cl- cotransport in regulatory volume decrease.
The American journal of physiology 1995;268(4 Pt 1):C894-902.
1995: Carlo Brugnara; C C Armsby; Masayuki Sakamoto; Nader Rifai; Seth L Alper; O Platt
Oral administration of clotrimazole and blockade of human erythrocyte Ca(++)-activated K+ channel: the imidazole ring is not required for inhibitory activity.
The Journal of pharmacology and experimental therapeutics 1995;273(1):266-72.
1995: Petr Jarolim; HL Rubin; V Brabec; L Chrobak; A S Zolotarev; Seth L Alper; Carlo Brugnara; H Wichterle; J Palek
Mutations of conserved arginines in the membrane domain of erythroid band 3 lead to a decrease in membrane-associated band 3 and to the phenotype of hereditary spherocytosis.
Blood 1995;85(3):634-40.
1995: B D Humphreys; Lianwei Jiang; Marina N Chernova; Seth L Alper
Hypertonic activation of AE2 anion exchanger in Xenopus oocytes via NHE-mediated intracellular alkalinization.
The American journal of physiology 1995;268(1 Pt 1):C201-9.
1994: B D Humphreys; Lianwei Jiang; Marina N Chernova; Seth L Alper
Functional characterization and regulation by pH of murine AE2 anion exchanger expressed in Xenopus oocytes.
The American journal of physiology 1994;267(5 Pt 1):C1295-307.
1994: D Yannoukakos; Alan K Stuart-Tilley; H A Fernandez; P Fey; G Duyk; Seth L Alper
Molecular cloning, expression, and chromosomal localization of two isoforms of the AE3 anion exchanger from human heart.
Circulation research 1994;75(4):603-14.
1994: Lianwei Jiang; Alan K Stuart-Tilley; J Parkash; Seth L Alper
pHi and serum regulate AE2-mediated Cl-/HCO3- exchange in CHOP cells of defined transient transfection status.
The American journal of physiology 1994;267(3 Pt 1):C845-56.
1994: Seth L Alper; Alan K Stuart-Tilley; C F Simmons; D Brown; D Drenckhahn
The fodrin-ankyrin cytoskeleton of choroid plexus preferentially colocalizes with apical Na+K(+)-ATPase rather than with basolateral anion exchanger AE2.
The Journal of clinical investigation 1994;93(4):1430-8.
1994: J V Frangioni; N Moghal; Alan K Stuart-Tilley; Benjamin G Neel; Seth L Alper
The DNA binding domain of retinoic acid receptor beta is required for ligand-dependent suppression of proliferation. Application of general purpose mammalian coexpression vectors.
Journal of cell science 1994;107 ( Pt 4)():827-38.
1994: Lucia De Franceschi; N Saadane; Marie Trudel; Seth L Alper; Carlo Brugnara; Yves Beuzard
Treatment with oral clotrimazole blocks Ca(2+)-activated K+ transport and reverses erythrocyte dehydration in transgenic SAD mice. A model for therapy of sickle cell disease.
The Journal of clinical investigation 1994;93(4):1670-6.
1994: Alan K Stuart-Tilley; C Sardet; J Pouyssegur; M A Schwartz; D Brown; Seth L Alper
Immunolocalization of anion exchanger AE2 and cation exchanger NHE-1 in distinct adjacent cells of gastric mucosa.
The American journal of physiology 1994;266(2 Pt 1):C559-68.
1994: Petr Jarolim; HL Rubin; Shih-Chun Liu; Michael R Cho; V Brabec; L H Derick; S J Yi; Sara T O Saad; Seth L Alper; Carlo Brugnara
Duplication of 10 nucleotides in the erythroid band 3 (AE1) gene in a kindred with hereditary spherocytosis and band 3 protein deficiency (band 3PRAGUE).
The Journal of clinical investigation 1994;93(1):121-30.
1993: C Haller; Seth L Alper
Nonpolarized surface distribution and delivery of human CD7 in polarized MDCK cells.
The American journal of physiology 1993;265(4 Pt 1):C1069-79.
1993: Carlo Brugnara; Lucia De Franceschi; Seth L Alper
Inhibition of Ca(2+)-dependent K+ transport and cell dehydration in sickle erythrocytes by clotrimazole and other imidazole derivatives.
The Journal of clinical investigation 1993;92(1):520-6.
1993: Carlo Brugnara; L De Franceschi; Seth L Alper
Ca(2+)-activated K+ transport in erythrocytes. Comparison of binding and transport inhibition by scorpion toxins.
The Journal of biological chemistry 1993;268(12):8760-8.
1992: LOUIS ERCOLANI; Dennis Brown; Alan K Stuart-Tilley; Seth L Alper
Colocalization of GAPDH and band 3 (AE1) proteins in rat erythrocytes and kidney intercalated cell membranes.
The American journal of physiology 1992;262(5 Pt 2):F892-6.
1991: Seth L Alper
The band 3-related anion exchanger (AE) gene family.
Annual review of physiology 1991;53():549-64.
1989: Frank C Brosius III; Seth L Alper; A M Garcia; Harvey Lodish
The major kidney band 3 gene transcript predicts an amino-terminal truncated band 3 polypeptide.
The Journal of biological chemistry 1989;264(14):7784-7.
1989: Maureen J Charron; Frank C Brosius III; Seth L Alper; Harvey Lodish
A glucose transport protein expressed predominately in insulin-responsive tissues.
Proceedings of the National Academy of Sciences of the United States of America 1989;86(8):2535-9.
1988: Seth L Alper; R R Kopito; S M Libresco; Harvey Lodish
Cloning and characterization of a murine band 3-related cDNA from kidney and from a lymphoid cell line.
The Journal of biological chemistry 1988;263(32):17092-9.
1987: Seth L Alper; R R Kopito; Harvey Lodish
A molecular biological approach to the study of anion transport.
Kidney international. Supplement 1987;23():S117-33.