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David Alpers

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David H Alpers; GJ Russell-Jones
Gastric intrinsic factor: the gastric and small intestinal stages of cobalamin absorption. a personal journey.
David H Alpers
Intraluminal bioavailability of divalent cations.
Bernard J DuBray; Jianluo Jia; Brett L Knolhoff; Thallachallour Mohanakumar; Gundumi A Upadhya; David H Alpers; Parvathi Balachandran; William C Chapman; Kendra D Conzen; Christopher D Anderson
Novel in vitro model for studying hepatic ischemia-reperfusion injury using liver cubes.

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All Publications

2013: David H Alpers; GJ Russell-Jones
Gastric intrinsic factor: the gastric and small intestinal stages of cobalamin absorption. a personal journey.
Biochimie 2013;95(5):989-94.
2013: David H Alpers
Intraluminal bioavailability of divalent cations.
Current opinion in gastroenterology 2013;29(2):164-9.
2012: Bernard J DuBray; Jianluo Jia; Brett L Knolhoff; Thallachallour Mohanakumar; Gundumi A Upadhya; David H Alpers; Parvathi Balachandran; William C Chapman; Kendra D Conzen; Christopher D Anderson
Novel in vitro model for studying hepatic ischemia-reperfusion injury using liver cubes.
Surgery 2012;152(2):247-53.
2012: David H Alpers
Subclinical micronutrient deficiency: a problem in recognition.
Current opinion in gastroenterology 2012;28(2):135-8.
2011: David H Alpers
Vitamins as drugs: the importance of pharmacokinetics in oral dosing.
Current opinion in gastroenterology 2011;27(2):146-51.
2010: David H Alpers
Nutrient sensing in the gastrointestinal tract.
Current opinion in gastroenterology 2010;26(2):134-9.
2008: David H Alpers
Multidimensionality of symptom complexes in irritable bowel syndrome and other functional gastrointestinal disorders.
Journal of psychosomatic research 2008;64(6):567-72.
2008: David H Alpers
The potential use of curcumin in management of chronic disease: too good to be true?
Current opinion in gastroenterology 2008;24(2):173-5.
2007: Chandra Prakash Gyawali; Gregory S Sayuk; David H Alpers
Ray E. Clouse, MD, Washington University gastroenterologist, clinical investigator, and educator.
Gastroenterology 2007;133(5):1404-6.
2007: Sonoko Narisawa; Marc F Hoylaerts; Kutbuddin S Doctor; Michiko N Fukuda; David H Alpers; José Luis Millán
A novel phosphatase upregulated in Akp3 knockout mice.
American journal of physiology. Gastrointestinal and liver physiology 2007;293(5):G1068-77.
2007: F Scott Mathews; Marilyn M Gordon; Zhiwei Chen; K R Rajashankar; S E Ealick; David H Alpers; Narayanasami Sukumar
Crystal structure of human intrinsic factor: cobalamin complex at 2.6-A resolution.
Proceedings of the National Academy of Sciences of the United States of America 2007;104(44):17311-6.
2007: Takanari Nakano; Ikuo Inoue; Iwao Koyama; Kenta Kanazawa; Koh-Ichi Nakamura; Sonoko Narisawa; Kayoko Tanaka; Masumi Akita; Taku Masuyama; Makoto Seo; Shigeru Hokari; Shigehiro Katayama; David H Alpers; José Luis Millán; Tsugikazu Komoda
Disruption of the murine intestinal alkaline phosphatase gene Akp3 impairs lipid transcytosis and induces visceral fat accumulation and hepatic steatosis.
American journal of physiology. Gastrointestinal and liver physiology 2007;292(5):G1439-49.
2006: David H Alpers
Glutamine: do the data support the cause for glutamine supplementation in humans?
Gastroenterology 2006;130(2 Suppl 1):S106-16.
2004: Fawwaz Yassin; Sheldon P Rothenberg; Sreedhar Rao; Marilyn M Gordon; David H Alpers; Edward V Quadros
Identification of a 4-base deletion in the gene in inherited intrinsic factor deficiency.
Blood 2004;103(4):1515-7.
2004: Marilyn M Gordon; Nancy Brada; Angel F Remacha; Isabel Badell; Elisabeth del Río; Montserrat Baiget; René Santer; Edward V Quadros; Sheldon P Rothenberg; David H Alpers
A genetic polymorphism in the coding region of the gastric intrinsic factor gene (GIF) is associated with congenital intrinsic factor deficiency.
Human mutation 2004;23(1):85-91.
2003: Sonoko Narisawa; Lei Huang; Arata Iwasaki; Hideaki Hasegawa; David H Alpers; José Luis Millán
Accelerated fat absorption in intestinal alkaline phosphatase knockout mice.
Molecular and cellular biology 2003;23(21):7525-30.
2003: Akhtar Mahmood; Jian-Su Shao; David H Alpers
Rat enterocytes secrete SLPs containing alkaline phosphatase and cubilin in response to corn oil feeding.
American journal of physiology. Gastrointestinal and liver physiology 2003;285(2):G433-41.
2002: Akhtar Mahmood; Michael J Engle; David H Alpers
Secreted intestinal surfactant-like particles interact with cell membranes and extracellular matrix proteins in rats.
The Journal of physiology 2002;542(Pt 1):237-44.
2001: Michael J Engle; David H Alpers
Surfactant-like particles mediate tissue-specific functions in epithelial cells.
Comparative biochemistry and physiology. Part A, Molecular & integrative physiology 2001;129(1):163-71.
2001: Michael J Engle; A Mahmood; David H Alpers
Regulation of surfactant-like particle secretion by Caco-2 cells.
Biochimica et biophysica acta 2001;1511(2):369-80.
2001: Takeshi Nikawa; Madoka Ikemoto; K Tokuoka; Shigetada Teshima; David H Alpers; Y Masui; Kyoichi Kishi; Kazuhito Rokutan
Interleukin-1beta enhances retinoic acid-mediated expression of bone-type alkaline phosphatase in rat IEC-6 cells.
American journal of physiology. Gastrointestinal and liver physiology 2001;280(3):G510-7.
2000: N Brada; Marilyn M Gordon; Jian-Su Shao; J Wen; David H Alpers
Production of gastric intrinsic factor, transcobalamin, and haptocorrin in opossum kidney cells.
American journal of physiology. Renal physiology 2000;279(6):F1006-13.
2000: Jian-Su Shao; Michael J Engle; Q Xie; R E Schmidt; Sonoko Narisawa; José Luis Millan; David H Alpers
Effect of tissue non-specific alkaline phosphatase in maintenance of structure of murine colon and stomach.
Microscopy research and technique 2000;51(2):121-8.
2000: J Shao; Ryan Sartor; Elizabeth J Dial; L M Lichtenberger; W Schepp; David H Alpers
Expression of intrinsic factor in rat and murine gastric mucosal cell lineages is modified by inflammation.
The American journal of pathology 2000;157(4):1197-205.
2000: A Mahmood; Michael J Engle; S J Hultgren; GS Goetz; K Dodson; David H Alpers
Role of intestinal surfactant-like particles as a potential reservoir of uropathogenic Escherichia coli.
Biochimica et biophysica acta 2000;1523(1):49-55.
2000: J Wen; M B Kinnear; M A Richardson; N S Willetts; GJ Russell-Jones; Marilyn M Gordon; David H Alpers
Functional expression in Pichia pastoris of human and rat intrinsic factor.
Biochimica et biophysica acta 2000;1490(1-2):43-53.
2000: David H Alpers; N M Bass; Michael J Engle; K DeSchryver-Kecskemeti
Intestinal fatty acid binding protein may favor differential apical fatty acid binding in the intestine.
Biochimica et biophysica acta 2000;1483(3):352-62.
1999: GS Goetz; A Mahmood; S J Hultgren; Michael J Engle; K Dodson; David H Alpers
Binding of pili from uropathogenic Escherichia coli to membranes secreted by human colonocytes and enterocytes.
Infection and immunity 1999;67(11):6161-3.
1999: Q M Xie; Jian-Su Shao; David H Alpers
Rat intestinal alpha1-antitrypsin secretion is regulated by triacylglycerol feeding.
The American journal of physiology 1999;276(6 Pt 1):G1452-60.
1999: GJ Russell-Jones; David H Alpers
Vitamin B12 transporters.
Pharmaceutical biotechnology 1999;12():493-520.
1998: Takeshi Nikawa; Kazuhito Rokutan; K Nanba; K Tokuoka; Shigetada Teshima; Michael J Engle; David H Alpers; Kyoichi Kishi
Vitamin A up-regulates expression of bone-type alkaline phosphatase in rat small intestinal crypt cell line and fetal rat small intestine.
The Journal of nutrition 1998;128(11):1869-77.
1998: Michael J Engle; GS Goetz; David H Alpers
Caco-2 cells express a combination of colonocyte and enterocyte phenotypes.
Journal of cellular physiology 1998;174(3):362-9.
1998: Jian-Su Shao; W Schepp; David H Alpers
Expression of intrinsic factor and pepsinogen in the rat stomach identifies a subset of parietal cells.
The American journal of physiology 1998;274(1 Pt 1):G62-70.
1997: J Z Mu; M Gordon; Jian-Su Shao; David H Alpers
Apical expression of functional asialoglycoprotein receptor in the human intestinal cell line HT-29.
Gastroenterology 1997;113(5):1501-9.
1997: David H Alpers; S Klein
The centennial year: the development of important ideas during the last 100 years. Nutrition and the gastroenterologist: the last 100 years.
Gastroenterology 1997;113(2):675-9.
1997: Brian K Dieckgraefe; D M Weems; S A Santoro; David H Alpers
ERK and p38 MAP kinase pathways are mediators of intestinal epithelial wound-induced signal transduction.
Biochemical and biophysical research communications 1997;233(2):389-94.
1997: R Eliakim; GS Goetz; S Rubio; Bernadette Chailley-Heu; Jian-Su Shao; Robert Ducroc; David H Alpers
Isolation and characterization of surfactant-like particles in rat and human colon.
The American journal of physiology 1997;272(3 Pt 1):G425-34.
1997: J Wen; Marilyn M Gordon; David H Alpers
A receptor binding site on intrinsic factor is located between amino acids 25-44 and interacts with other parts of the protein.
Biochemical and biophysical research communications 1997;231(2):348-51.
1997: Q M Xie; Y Zhang; S Mahmood; David H Alpers
Rat intestinal alkaline phosphatase II messenger RNA is present in duodenal crypt and villus cells.
Gastroenterology 1997;112(2):376-86.
1997: Marilyn M Gordon; GJ Russell-Jones; David H Alpers
Expression of functional intrinsic factor using recombinant baculovirus.
Methods in enzymology 1997;281():255-61.
1996: T A Howard; D N Misra; M Grove; Michael Becich; J S Shao; M Gordon; David H Alpers
Human gastric intrinsic factor expression is not restricted to parietal cells.
Journal of anatomy 1996;189 ( Pt 2)():303-13.
1996: R Eliakim; David H Alpers; R Oren; A Fich; K DeSchryver-Kecskemeti
Abundance of surfactant-like particles reflects mucosal integrity in patients with peptic ulcer disease.
Gut 1996;39(3):353-9.
1996: David H Alpers; T Yamada
Centennial report to American Gastroenterological Association members.
Gastroenterology 1996;110(5):1644-6.
1996: Y Zhang; Jian-Su Shao; Q M Xie; David H Alpers
Immunolocalization of alkaline phosphatase and surfactant-like particle proteins in rat duodenum during fat absorption.
Gastroenterology 1996;110(2):478-88.
1996: Brian K Dieckgraefe; Samuel A Santoro; David H Alpers
Immunolocalization of alpha-integrin subunits and extracellular matrix components during human colonic organogenesis.
Gastroenterology 1996;110(1):58-71.
1995: David H Alpers; Y Zhang; D J Ahnen
Synthesis and parallel secretion of rat intestinal alkaline phosphatase and a surfactant-like particle protein.
The American journal of physiology 1995;268(6 Pt 1):E1205-14.
1995: M J Engle; M L Grove; Michael Becich; A Mahmood; David H Alpers
Appearance of surfactant-like particles in apical medium of Caco-2 cells may occur via tight junctions.
The American journal of physiology 1995;268(6 Pt 1):C1401-13.
1995: M J Engle; A Mahmood; David H Alpers
Two rat intestinal alkaline phosphatase isoforms with different carboxyl-terminal peptides are both membrane-bound by a glycan phosphatidylinositol linkage.
The Journal of biological chemistry 1995;270(20):11935-40.
1995: M M Gordon; T Howard; Michael Becich; David H Alpers
Cathepsin L mediates intracellular ileal digestion of gastric intrinsic factor.
The American journal of physiology 1995;268(1 Pt 1):G33-40.
1994: J Z Mu; robert joseph fallon; P E Swanson; S B Carroll; M Danaher; David H Alpers
Expression of an endogenous asialoglycoprotein receptor in a human intestinal epithelial cell line, Caco-2.
Biochimica et biophysica acta 1994;1222(3):483-91.
1994: F Yamagishi; T Komoda; David H Alpers
Secretion and distribution of rat intestinal surfactant-like particles after fat feeding.
The American journal of physiology 1994;266(5 Pt 1):G944-52.
1994: F Yamagishi; Michael Becich; B A Evans; T Komoda; David H Alpers
Clearance of surfactant-like particle proteins from circulation in rats.
The American journal of physiology 1994;266(4 Pt 1):G596-605.
1994: A Mahmood; F Yamagishi; R Eliakim; K DeSchryver-Kecskemeti; T L Gramlich; David H Alpers
A possible role for rat intestinal surfactant-like particles in transepithelial triacylglycerol transport.
The Journal of clinical investigation 1994;93(1):70-80.
1993: J Z Mu; L H Tang; David H Alpers
Asialoglycoprotein receptor mRNAs are expressed in most extrahepatic rat tissues during development.
The American journal of physiology 1993;264(4 Pt 1):G752-62.
1993: A Mahmood; S Mahmood; K DeSchryver-Kecskemeti; David H Alpers
Characterization of proteins in rat and human intestinal surfactant-like particles.
Archives of biochemistry and biophysics 1993;300(1):280-6.
1992: L H Tang; H Chokshi; C B Hu; M M Gordon; David H Alpers
The intrinsic factor (IF)-cobalamin receptor binding site is located in the amino-terminal portion of IF.
The Journal of biological chemistry 1992;267(32):22982-6.
1992: C C Tietze; Michael Becich; M Engle; William F Stenson; A Mahmood; R Eliakim; David H Alpers
Caco-2 cell transfection by rat intestinal alkaline phosphatase cDNA increases surfactant-like particles.
The American journal of physiology 1992;263(5 Pt 1):G756-66.
1992: M Gordon; H Chokshi; David H Alpers
In vitro expression and secretion of functional mammalian intrinsic factor using recombinant baculovirus.
Biochimica et biophysica acta 1992;1132(3):276-83.
1992: R D Wagner; Elaine Krul; J B Moberly; David H Alpers; Gustav Schonfeld
Apolipoprotein expression and cellular differentiation in Caco-2 intestinal cells.
The American journal of physiology 1992;263(2 Pt 1):E374-82.
1992: Ray E Clouse; David H Alpers; D M Hockenbery; K DeSchryver-Kecskemeti
Pericrypt eosinophilic enterocolitis and chronic diarrhea.
Gastroenterology 1992;103(1):168-76.
1991: C B Hu; E Y Lee; J E Hewitt; J U Baenziger; J Z Mu; K DeSchryver-Kecskemeti; David H Alpers
The minor components of the rat asialoglycoprotein receptor are apically located in neonatal enterocytes.
Gastroenterology 1991;101(6):1477-87.
1991: J E Hewitt; M M Gordon; R T Taggart; T K Mohandas; David H Alpers
Human gastric intrinsic factor: characterization of cDNA and genomic clones and localization to human chromosome 11.
Genomics 1991;10(2):432-40.
1991: M M Gordon; C Hu; H Chokshi; J E Hewitt; David H Alpers
Glycosylation is not required for ligand or receptor binding by expressed rat intrinsic factor.
The American journal of physiology 1991;260(5 Pt 1):G736-42.
1991: R Eliakim; A Mahmood; David H Alpers
Rat intestinal alkaline phosphatase secretion into lumen and serum is coordinately regulated.
Biochimica et biophysica acta 1991;1091(1):1-8.
1990: R Eliakim; Michael Becich; K Green; David H Alpers
Both tissue and serum phospholipases release rat intestinal alkaline phosphatase.
The American journal of physiology 1990;259(4 Pt 1):G618-25.
1990: R Eliakim; S Seetharam; C C Tietze; David H Alpers
Differential regulation of mRNAs encoding for rat intestinal alkaline phosphatase.
The American journal of physiology 1990;259(1 Pt 1):G93-8.
1990: J E Hewitt; Bellur Seetharam; J Leykam; David H Alpers
Isolation and characterization of a cDNA encoding porcine gastric haptocorrin.
European journal of biochemistry / FEBS 1990;189(1):125-30.
1990: M Ramasamy; David H Alpers; V Saxena; Bellur Seetharam
Effect of lectins on the cobalamin-protein binding reactions: implications for the tissue uptake of cobalamin.
The Journal of nutritional biochemistry 1990;1(4):213-9.
1990: M Lowe; Arnold W Strauss; R Alpers; S Seetharam; David H Alpers
Molecular cloning and expression of a cDNA encoding the membrane-associated rat intestinal alkaline phosphatase.
Biochimica et biophysica acta 1990;1037(2):170-7.
1990: J B Moberly; T G Cole; David H Alpers; Gustav Schonfeld
Oleic acid stimulation of apolipoprotein B secretion from HepG2 and Caco-2 cells occurs post-transcriptionally.
Biochimica et biophysica acta 1990;1042(1):70-80.
1990: David H Alpers; R Eliakim; K DeSchryver-Kecskemeti
Secretion of hepatic and intestinal alkaline phosphatases: similarities and differences.
Clinica chimica acta; international journal of clinical chemistry 1990;186(2):211-23.
1990: David H Alpers
Pre-translational, translational, and post-translational mechanisms in adaptation of intestinal proteins.
Digestion 1990;46 Suppl 2():50-8.
1989: R Eliakim; K DeSchryver-Kecskemeti; Lawrence M Nogee; William F Stenson; David H Alpers
Isolation and characterization of a small intestinal surfactant-like particle containing alkaline phosphatase and other digestive enzymes.
The Journal of biological chemistry 1989;264(34):20614-9.
1989: M Ramasamy; David H Alpers; C Tiruppathi; Bellur Seetharam
Cobalamin release from intrinsic factor and transfer to transcobalamin II within the rat enterocyte.
The American journal of physiology 1989;257(5 Pt 1):G791-7.
1988: Brian K Dieckgraefe; Bellur Seetharam; David H Alpers
Developmental regulation of rat intrinsic factor mRNA.
The American journal of physiology 1988;254(6 Pt 1):G913-9.
1988: M F Go; Gustav Schonfeld; B Pfleger; T G Cole; N L Sussman; David H Alpers
Regulation of intestinal and hepatic apoprotein synthesis after chronic fat and cholesterol feeding.
The Journal of clinical investigation 1988;81(5):1615-20.
1988: Bellur Seetharam; J S Levine; M Ramasamy; David H Alpers
Purification, properties, and immunochemical localization of a receptor for intrinsic factor-cobalamin complex in the rat kidney.
The Journal of biological chemistry 1988;263(9):4443-9.
1988: Brian K Dieckgraefe; Bellur Seetharam; L Banaszak; J F Leykam; David H Alpers
Isolation and structural characterization of a cDNA clone encoding rat gastric intrinsic factor.
Proceedings of the National Academy of Sciences of the United States of America 1988;85(1):46-50.
1987: C Tiruppathi; David H Alpers; Bellur Seetharam
The role of choline on the activity-temperature relationship of brush-border alkaline phosphatase.
Biochimica et biophysica acta 1987;898(3):283-92.
1987: Bellur Seetharam; C Tiruppathi; David H Alpers
Hydrophobic interactions of brush border alkaline phosphatases: the role of phosphatidyl inositol.
Archives of biochemistry and biophysics 1987;253(1):189-98.
1986: C Tiruppathi; David H Alpers; Bellur Seetharam
Phase separation of rat intestinal brush border membrane proteins using Triton X-114.
Analytical biochemistry 1986;153(2):330-5.
1985: C Tiruppathi; David H Alpers; Bellur Seetharam
Interaction of intestinal disaccharidases with phospholipids: effect of cholesterol.
Journal of pediatric gastroenterology and nutrition 1985;4(6):965-70.
1985: Bellur Seetharam; C Tiruppathi; David H Alpers
Membrane interactions of rat intestinal alkaline phosphatase: role of polar head groups.
Biochemistry 1985;24(23):6603-8.
1985: Bellur Seetharam; M Presti; B Frank; C Tiruppathi; David H Alpers
Intestinal uptake and release of cobalamin complexed with rat intrinsic factor.
The American journal of physiology 1985;248(3 Pt 1):G326-31.