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Gianfranco Alpini
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58
Francis, Heather
55
Glaser, Shannon
46
Alvaro, Domenico
42
Lesage, Gene
40
Marzioni, Marco
35
Benedetti, Antonio
33
Ueno, Yoshiyuki
31
Phinizy, Jo Lynne
28
Venter, Julie
23
DeMorrow, Sharon
23
Gaudio, Eugenio
22
Fava, Giammarco
22
Marucci, Luca
20
Glaser, Shannon
19
Franchitto, Antonio
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All Publications
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2009: Francis Heather; Onori Paolo; Gaudio Eugenio; Franchitto Antonio; DeMorrow Sharon; Venter Julie; Kopriva Shelley; Carpino Guido; Mancinelli Romina; White Mellanie; Meng Fanyin; Vetuschi Antonella; Sferra Roberta; Alpini Gianfranco
H3 histamine receptor-mediated activation of protein kinase Calpha inhibits the growth of cholangiocarcinoma in vitro and in vivo.
Molecular cancer research : MCR 2009;7(10):1704-13.
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2009: Omenetti Alessia; Syn Wing-Kin; Jung Youngmi; Francis Heather; Porrello Alessandro; Witek Rafal P; Choi Steve S; Yang Liu; Mayo Marlyn J; Gershwin M Eric; Alpini Gianfranco; Diehl Anna Mae
Repair-related activation of hedgehog signaling promotes cholangiocyte chemokine production.
Hepatology (Baltimore, Md.) 2009;50(2):518-27.
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2009: Mancinelli Romina; Onori Paolo; Gaudio Eugenio; DeMorrow Sharon; Franchitto Antonio; Francis Heather; Glaser Shannon; Carpino Guido; Venter Julie; Alvaro Domenico; Kopriva Shelley; White Mellanie; Kossie Ashley; Savage Jennifer; Alpini Gianfranco
Follicle-stimulating hormone increases cholangiocyte proliferation by an autocrine mechanism via cAMP-dependent phosphorylation of ERK1/2 and Elk-1.
American journal of physiology. Gastrointestinal and liver physiology 2009;297(1):G11-26.
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2009: Marzioni M; Alpini G; Saccomanno S; Candelaresi C; Venter J; Rychlicki C; Fava G; Francis H; Trozzi L; Benedetti A
Exendin-4, a glucagon-like peptide 1 receptor agonist, protects cholangiocytes from apoptosis.
Gut 2009;58(7):990-7.
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2009: Marzioni Marco; Fava Giammarco; Alvaro Domenico; Alpini Gianfranco; Benedetti Antonio
Control of cholangiocyte adaptive responses by visceral hormones and neuropeptides.
Clinical reviews in allergy & immunology 2009;36(1):13-22.
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2009: Mancino A; Mancino M G; Glaser S S; Alpini G; Bolognese A; Izzo L; Francis H; Onori P; Franchitto A; Ginanni-Corradini S; Gaudio E; Alvaro D
Estrogens stimulate the proliferation of human cholangiocarcinoma by inducing the expression and secretion of vascular endothelial growth factor.
Digestive and liver disease : official journal of the Italian Society of Gastroenterology and the Italian Association for the Study of the Liver 2009;41(2):156-63.
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2009: Alpini Gianfranco; Demorrow Sharon
Changes in the endocannabinoid system may give insight into new and effective treatments for cancer.
Vitamins and hormones 2009;81():469-85.
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2008: DeMorrow Sharon; Francis Heather; Gaudio Eugenio; Venter Julie; Franchitto Antonio; Kopriva Shelley; Onori Paolo; Mancinelli Romina; Frampton Gabriel; Coufal Monique; Mitchell Brett; Vaculin Bradley; Alpini Gianfranco
The endocannabinoid anandamide inhibits cholangiocarcinoma growth via activation of the noncanonical Wnt signaling pathway.
American journal of physiology. Gastrointestinal and liver physiology 2008;295(6):G1150-8.
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2008: Alpini Gianfranco; Invernizzi Pietro; Gaudio Eugenio; Venter Julie; Kopriva Shelley; Bernuzzi Francesca; Onori Paolo; Franchitto Antonio; Coufal Monique; Frampton Gabriel; Alvaro Domenico; Lee Sum P; Marzioni Marco; Benedetti Antonio; DeMorrow Sharon
Serotonin metabolism is dysregulated in cholangiocarcinoma, which has implications for tumor growth.
Cancer research 2008;68(22):9184-93.
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2008: Omenetti Alessia; Porrello Alessandro; Jung Youngmi; Yang Liu; Popov Yury; Choi Steve S; Witek Rafal P; Alpini Gianfranco; Venter Juliet; Vandongen Hendrika M; Syn Wing-Kin; Baroni Gianluca Svegliati; Benedetti Antonio; Schuppan Detlef; Diehl Anna Mae
Hedgehog signaling regulates epithelial-mesenchymal transition during biliary fibrosis in rodents and humans.
The Journal of clinical investigation 2008;118(10):3331-42.
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2008: Gatto Manuela; Drudi-Metalli Veronica; Torrice Alessia; Alpini Gianfranco; Cantafora Alfredo; Blotta Ida; Alvaro Domenico
Insulin-like growth factor-1 isoforms in rat hepatocytes and cholangiocytes and their involvement in protection against cholestatic injury.
Laboratory investigation; a journal of technical methods and pathology 2008;88(9):986-94.
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2008: Fava Giammarco; Alpini Gianfranco; Rychlicki Chiara; Saccomanno Stefania; DeMorrow Sharon; Trozzi Luciano; Candelaresi Cinzia; Venter Julie; Di Sario Antonio; Marzioni Marco; Bearzi Italo; Glaser Shannon; Alvaro Domenico; Marucci Luca; Francis Heather; Svegliati-Baroni Gianluca; Benedetti Antonio
Leptin enhances cholangiocarcinoma cell growth.
Cancer research 2008;68(16):6752-61.
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2008: Francis Heather; Glaser Shannon; Demorrow Sharon; Gaudio Eugenio; Ueno Yoshiyuki; Venter Julie; Dostal David; Onori Paolo; Franchitto Antonio; Marzioni Marco; Vaculin Shelley; Vaculin Bradley; Katki Khurshed; Stutes Monique; Savage Jennifer; Alpini Gianfranco
Small mouse cholangiocytes proliferate in response to H1 histamine receptor stimulation by activation of the IP3/CaMK I/CREB pathway.
American journal of physiology. Cell physiology 2008;295(2):C499-513.
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2008: Glaser Shannon; DeMorrow Sharon; Francis Heather; Ueno Yoshiyuki; Gaudio Eugenio; Vaculin Shelley; Venter Julie; Franchitto Antonio; Onori Paolo; Vaculin Bradley; Marzioni Marco; Wise Candace; Pilanthananond Metaneeya; Savage Jennifer; Pierce Lisa; Mancinelli Romina; Alpini Gianfranco
Progesterone stimulates the proliferation of female and male cholangiocytes via autocrine/paracrine mechanisms.
American journal of physiology. Gastrointestinal and liver physiology 2008;295(1):G124-G136.
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2008: Socoteanu Matei-P; Mott Frank; Alpini Gianfranco; Frankel Arthur-E
c-Met targeted therapy of cholangiocarcinoma.
World journal of gastroenterology : WJG 2008;14(19):2990-4.
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2008: Wise Candace; Pilanthananond Metaneeya; Perry Benjamin-F; Alpini Gianfranco; McNeal Michael; Glaser Shannon-S
Mechanisms of biliary carcinogenesis and growth.
World journal of gastroenterology : WJG 2008;14(19):2986-9.
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2008: Alvaro Domenico; Onori Paolo; Alpini Gianfranco; Franchitto Antonio; Jefferson Douglas M; Torrice Alessia; Cardinale Vincenzo; Stefanelli Fabrizio; Mancino Maria Grazia; Strazzabosco Mario; Angelico Mario; Attili Adolfo; Gaudio Eugenio
Morphological and functional features of hepatic cyst epithelium in autosomal dominant polycystic kidney disease.
The American journal of pathology 2008;172(2):321-32.
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2008: DeMorrow Sharon; Francis Heather; Gaudio Eugenio; Ueno Yoshiyuki; Venter Julie; Onori Paolo; Franchitto Antonio; Vaculin Bradley; Vaculin Shelley; Alpini Gianfranco
Anandamide inhibits cholangiocyte hyperplastic proliferation via activation of thioredoxin 1/redox factor 1 and AP-1 activation.
American journal of physiology. Gastrointestinal and liver physiology 2008;294(2):G506-19.
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2007: Xia Xuefeng; Demorrow Sharon; Francis Heather; Glaser Shannon; Alpini Gianfranco; Marzioni Marco; Fava Giammarco; Lesage Gene
Cholangiocyte injury and ductopenic syndromes.
Seminars in liver disease 2007;27(4):401-12.
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2007: Fava Giammarco; Marzioni Marco; Francis Heather; Glaser Shannon; Demorrrow Sharon; Ueno Yoshiyuki; Benedetti Antonio; Alpini Gianfranco
Novel interaction of bile acid and neural signaling in the regulation of cholangiocyte function.
Hepatology research : the official journal of the Japan Society of Hepatology 2007;37 Suppl 3():S420-9.
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2007: Francis Heather; LeSage Gene; DeMorrow Sharon; Alvaro Domenico; Ueno Yoshiyuki; Venter Julie; Glaser Shannon; Mancino Maria Grazia; Marucci Luca; Benedetti Antonio; Alpini Gianfranco
The alpha2-adrenergic receptor agonist UK 14,304 inhibits secretin-stimulated ductal secretion by downregulation of the cAMP system in bile duct-ligated rats.
American journal of physiology. Cell physiology 2007;293(4):C1252-62.
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2007: Demorrow Sharon; Francis Heather; Alpini Gianfranco
Biogenic amine actions on cholangiocyte function.
Experimental biology and medicine (Maywood, N.J.) 2007;232(8):1005-13.
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2007: Lleo Ana; Invernizzi Pietro; Selmi Carlo; Coppel Ross L; Alpini Gianfranco; Podda Mauro; Mackay Ian R; Gershwin M Eric
Autophagy: highlighting a novel player in the autoimmunity scenario.
Journal of autoimmunity 2007;29(2-3):61-8.
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2007: Glaser Shannon S; Ueno Yoshiyuki; DeMorrow Sharon; Chiasson Valorie L; Katki Khurshed A; Venter Julie; Francis Heather L; Dickerson Ian M; DiPette Donald J; Supowit Scott C; Alpini Gianfranco D
Knockout of alpha-calcitonin gene-related peptide reduces cholangiocyte proliferation in bile duct ligated mice.
Laboratory investigation; a journal of technical methods and pathology 2007;87(9):914-26.
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2007: Salunga Thucydides L; Cui Zheng-Guo; Shimoda Shinji; Zheng Hua-Chuan; Nomoto Kazuhiro; Kondo Takashi; Takano Yasuo; Selmi Carlo; Alpini Gianfranco; Gershwin M Eric; Tsuneyama Koichi
Oxidative stress-induced apoptosis of bile duct cells in primary biliary cirrhosis.
Journal of autoimmunity 2007;29(2-3):78-86.
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2007: Marzioni Marco; Alpini Gianfranco; Saccomanno Stefania; Candelaresi Cinzia; Venter Juliet; Rychlicki Chiara; Fava Giammarco; Francis Heather; Trozzi Luciano; Glaser Shannon; Benedetti Antonio
Glucagon-like peptide-1 and its receptor agonist exendin-4 modulate cholangiocyte adaptive response to cholestasis.
Gastroenterology 2007;133(1):244-55.
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2007: Ueno Yoshiyuki; Francis Heather; Glaser Shannon; Demorrow Sharon; Venter Julie; Benedetti Antonio; Fava Giammarco; Marzioni Marco; Alpini Gianfranco
Taurocholic acid feeding prevents tumor necrosis factor-alpha-induced damage of cholangiocytes by a PI3K-mediated pathway.
Experimental biology and medicine (Maywood, N.J.) 2007;232(7):942-9.
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2007: Drudi Metalli V; Mancino M G; Mancino A; Torrice A; Gatto M; Attili A F; Alpini G; Alvaro D
Bile salts regulate proliferation and apoptosis of liver cells by modulating the IGF1 system.
Digestive and liver disease : official journal of the Italian Society of Gastroenterology and the Italian Association for the Study of the Liver 2007;39(7):654-62.
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2007: Fava Giammarco; Marzioni Marco; Benedetti Antonio; Glaser Shannon; DeMorrow Sharon; Francis Heather; Alpini Gianfranco
Molecular pathology of biliary tract cancers.
Cancer letters 2007;250(2):155-67.
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2007: Marzioni Marco; Ueno Yoshiyuki; Glaser Shannon; Francis Heather; Benedetti Antonio; Alvaro Domenico; Venter Juliet; Fava Giammarco; Alpini Gianfranco
Cytoprotective effects of taurocholic acid feeding on the biliary tree after adrenergic denervation of the liver.
Liver international : official journal of the International Association for the Study of the Liver 2007;27(4):558-68.
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2007: Francis Heather; Franchitto Antonio; Ueno Yoshiyuki; Glaser Shannon; DeMorrow Sharon; Venter Julie; Gaudio Eugenio; Alvaro Domenico; Fava Giammarco; Marzioni Marco; Vaculin Bradley; Alpini Gianfranco
H3 histamine receptor agonist inhibits biliary growth of BDL rats by downregulation of the cAMP-dependent PKA/ERK1/2/ELK-1 pathway.
Laboratory investigation; a journal of technical methods and pathology 2007;87(5):473-87.
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2007: DeMorrow Sharon; Glaser Shannon; Francis Heather; Venter Julie; Vaculin Bradley; Vaculin Shelley; Alpini Gianfranco
Opposing actions of endocannabinoids on cholangiocarcinoma growth: recruitment of Fas and Fas ligand to lipid rafts.
The Journal of biological chemistry 2007;282(17):13098-113.
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2007: Marzioni Marco; Svegliati Baroni Gianluca; Alpini Gianfranco; Benedetti Antonio
Endogenous opioid peptides and chronic liver disease: from bedside to bench.
Journal of hepatology 2007;46(4):583-6.
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2007: Fava Giammarco; Ueno Yoshiyuki; Glaser Shannon; Francis Heather; Demorrow Sharon; Marucci Luca; Marzioni Marco; Benedetti Antonio; Venter Julie; Vaculin Bradley; Vaculin Shelley; Alpini Gianfranco
Thyroid hormone inhibits biliary growth in bile duct-ligated rats by PLC/IP(3)/Ca(2+)-dependent downregulation of SRC/ERK1/2.
American journal of physiology. Cell physiology 2007;292(4):C1467-75.
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2007: Alvaro Domenico; Mancino Maria Grazia; Glaser Shannon; Gaudio Eugenio; Marzioni Marco; Francis Heather; Alpini Gianfranco
Proliferating cholangiocytes: a neuroendocrine compartment in the diseased liver.
Gastroenterology 2007;132(1):415-31.
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2007: Di Sario A; Bendia E; Omenetti A; De Minicis S; Marzioni M; Kleemann H W; Candelaresi C; Saccomanno S; Alpini G; Benedetti A
Selective inhibition of ion transport mechanisms regulating intracellular pH reduces proliferation and induces apoptosis in cholangiocarcinoma cells.
Digestive and liver disease : official journal of the Italian Society of Gastroenterology and the Italian Association for the Study of the Liver 2007;39(1):60-9.
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2007: Taffetani Silvia; Glaser Shannon; Francis Heather; DeMorrow Sharon; Ueno Yoshiyuki; Alvaro Domenico; Marucci Luca; Marzioni Marco; Fava Giammarco; Venter Julie; Vaculin Shelley; Vaculin Bradley; Lam Ian Pak-Yan; Lee Vien Hoi-Yi; Gaudio Eugenio; Carpino Guido; Benedetti Antonio; Alpini Gianfranco
Prolactin stimulates the proliferation of normal female cholangiocytes by differential regulation of Ca2+-dependent PKC isoforms.
BMC physiology 2007;7():6.
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2006: Alvaro Domenico; Barbaro Barbara; Franchitto Antonio; Onori Paolo; Glaser Shannon S; Alpini Gianfranco; Francis Heather; Marucci Luca; Sterpetti Paola; Ginanni-Corradini Stefano; Onetti Muda Andrea; Dostal David E; De Santis Adriano; Attili Adolfo F; Benedetti Antonio; Gaudio Eugenio
Estrogens and insulin-like growth factor 1 modulate neoplastic cell growth in human cholangiocarcinoma.
The American journal of pathology 2006;169(3):877-88.
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2006: Gaudio Eugenio; Barbaro Barbara; Alvaro Domenico; Glaser Shannon; Francis Heather; Franchitto Antonio; Onori Paolo; Ueno Yoshiyuki; Marzioni Marco; Fava Giammarco; Venter Julie; Reichenbach Ramona; Summers Ryun; Alpini Gianfranco
Administration of r-VEGF-A prevents hepatic artery ligation-induced bile duct damage in bile duct ligated rats.
American journal of physiology. Gastrointestinal and liver physiology 2006;291(2):G307-17.
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2006: Xia Xuefeng; Francis Heather; Glaser Shannon; Alpini Gianfranco; LeSage Gene
Bile acid interactions with cholangiocytes.
World journal of gastroenterology : WJG 2006;12(22):3553-63.
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2006: Gaudio Eugenio; Franchitto Antonio; Pannarale Luigi; Carpino Guido; Alpini Gianfranco; Francis Heather; Glaser Shannon; Alvaro Domenico; Onori Paolo
Cholangiocytes and blood supply.
World journal of gastroenterology : WJG 2006;12(22):3546-52.
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2006: Alvaro Domenico; Mancino Maria Grazia; Onori Paolo; Franchitto Antonio; Alpini Gianfranco; Francis Heather; Glaser Shannon; Gaudio Eugenio
Estrogens and the pathophysiology of the biliary tree.
World journal of gastroenterology : WJG 2006;12(22):3537-45.
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2006: Glaser Shannon; Francis Heather; Demorrow Sharon; Lesage Gene; Fava Giammarco; Marzioni Marco; Venter Julie; Alpini Gianfranco
Heterogeneity of the intrahepatic biliary epithelium.
World journal of gastroenterology : WJG 2006;12(22):3523-36.
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2006: Svegliati-Baroni Gianluca; Ghiselli Roberto; Marzioni Marco; Alvaro Domenico; Mocchegiani Federico; Saccomanno Stefania; Sisti Valerio; Ugili Laura; Orlando Fiorenza; Alpini Gianfranco; Saba Vittorio; Benedetti Antonio
Estrogens maintain bile duct mass and reduce apoptosis after biliodigestive anastomosis in bile duct ligated rats.
Journal of hepatology 2006;44(6):1158-66.
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2006: Marzioni Marco; Alpini Gianfranco; Saccomanno Stefania; de Minicis Samuele; Glaser Shannon; Francis Heather; Trozzi Luciano; Venter Juliet; Orlando Fiorenza; Fava Giammarco; Candelaresi Cinzia; Macarri Giampiero; Benedetti Antonio
Endogenous opioids modulate the growth of the biliary tree in the course of cholestasis.
Gastroenterology 2006;130(6):1831-47.
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2006: Gaudio Eugenio; Barbaro Barbara; Alvaro Domenico; Glaser Shannon; Francis Heather; Ueno Yoshiyuki; Meininger Cynthia J; Franchitto Antonio; Onori Paolo; Marzioni Marco; Taffetani Silvia; Fava Giammarco; Stoica George; Venter Julie; Reichenbach Ramona; De Morrow Sharon; Summers Ryun; Alpini Gianfranco
Vascular endothelial growth factor stimulates rat cholangiocyte proliferation via an autocrine mechanism.
Gastroenterology 2006;130(4):1270-82.
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2006: Glaser Shannon; Alvaro Domenico; Francis Heather; Ueno Yoshiyuki; Marucci Luca; Benedetti Antonio; De Morrow Sharon; Marzioni Marco; Mancino Maria Grazia; Phinizy Jo Lynne; Reichenbach Ramona; Fava Giammarco; Summers Ryun; Venter Julie; Alpini Gianfranco
Adrenergic receptor agonists prevent bile duct injury induced by adrenergic denervation by increased cAMP levels and activation of Akt.
American journal of physiology. Gastrointestinal and liver physiology 2006;290(4):G813-26.
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2006: Sterpetti Paola; Marucci Luca; Candelaresi Cinzia; Toksoz Deniz; Alpini Gianfranco; Ugili Laura; Baroni Gianluca Svegliati; Macarri Giampiero; Benedetti Antonio
Cell proliferation and drug resistance in hepatocellular carcinoma are modulated by Rho GTPase signals.
American journal of physiology. Gastrointestinal and liver physiology 2006;290(4):G624-32.
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2006: Marzioni Marco; Francis Heather; Benedetti Antonio; Ueno Yoshiyuki; Fava Giammarco; Venter Juliet; Reichenbach Ramona; Mancino Maria Grazia; Summers Ryun; Alpini Gianfranco; Glaser Shannon
Ca2+-dependent cytoprotective effects of ursodeoxycholic and tauroursodeoxycholic acid on the biliary epithelium in a rat model of cholestasis and loss of bile ducts.
The American journal of pathology 2006;168(2):398-409.
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2005: Fava Giammarco; Marucci Luca; Glaser Shannon; Francis Heather; De Morrow Sharon; Benedetti Antonio; Alvaro Domenico; Venter Julie; Meininger Cynthia; Patel Tushar; Taffetani Silvia; Marzioni Marco; Summers Ryun; Reichenbach Ramona; Alpini Gianfranco
gamma-Aminobutyric acid inhibits cholangiocarcinoma growth by cyclic AMP-dependent regulation of the protein kinase A/extracellular signal-regulated kinase 1/2 pathway.
Cancer research 2005;65(24):11437-46.
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2005: Alvaro Domenico; Metalli Veronica Drudi; Alpini Gianfranco; Onori Paolo; Franchitto Antonio; Barbaro Barbara; Glaser Shannon S; Francis Heather; Cantafora Alfredo; Blotta Ida; Attili Adolfo Francesco; Gaudio Eugenio
The intrahepatic biliary epithelium is a target of the growth hormone/insulin-like growth factor 1 axis.
Journal of hepatology 2005;43(5):875-83.
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2005: Fava Giammarco; Glaser Shannon; Francis Heather; Alpini Gianfranco
The immunophysiology of biliary epithelium.
Seminars in liver disease 2005;25(3):251-64.
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2005: Taffetani Silvia; Ueno Yoshiyuki; Meng Fanyin; Venter Julie; Francis Heather; Glaser Shannon; Alpini Gianfranco; Patel Tushar
Tannic acid inhibits cholangiocyte proliferation after bile duct ligation via a cyclic adenosine 5',3'-monophosphate-dependent pathway.
The American journal of pathology 2005;166(6):1671-9.
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2005: Alpini Gianfranco; Glaser Shannon; Baiocchi Leonardo; Francis Heather; Xia Xuefeng; Lesage Gene
Secretin activation of the apical Na+-dependent bile acid transporter is associated with cholehepatic shunting in rats.
Hepatology (Baltimore, Md.) 2005;41(5):1037-45.
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2005: Marzioni Marco; Glaser Shannon; Francis Heather; Marucci Luca; Benedetti Antonio; Alvaro Domenico; Taffetani Silvia; Ueno Yoshiyuki; Roskams Tania; Phinizy Jo Lynne; Venter Juliet; Fava Giammarco; Lesage Gene D; Alpini Gianfranco
Autocrine/paracrine regulation of the growth of the biliary tree by the neuroendocrine hormone serotonin.
Gastroenterology 2005;128(1):121-37.
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2005: Gaudio E; Onori P; Franchitto A; Pannarale L; Alpini G; Alvaro D
Hepatic microcirculation and cholangiocyte physiopathology.
Italian journal of anatomy and embryology = Archivio italiano di anatomia ed embriologia 2005;110(2 Suppl 1):71-5.
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2004: LeSage Gene D; Alvaro Domenico; Glaser Shannon; Francis Heather; Marucci Luca; Roskams Tania; Phinizy Jo Lynne; Marzioni Marco; Benedetti Antonio; Taffetani Silvia; Barbaro Barbara; Fava Giammarco; Ueno Yoshiyuki; Alpini Gianfranco
Alpha-1 adrenergic receptor agonists modulate ductal secretion of BDL rats via Ca(2+)- and PKC-dependent stimulation of cAMP.
Hepatology (Baltimore, Md.) 2004;40(5):1116-27.
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2004: Gigliozzi Alessandro; Alpini Gianfranco; Baroni Gianluca Svegliati; Marucci Luca; Metalli Veronica Drudi; Glaser Shannon S; Francis Heather; Mancino Maria Grazia; Ueno Yoshiyuki; Barbaro Barbara; Benedetti Antonio; Attili Adolfo F; Alvaro Domenico
Nerve growth factor modulates the proliferative capacity of the intrahepatic biliary epithelium in experimental cholestasis.
Gastroenterology 2004;127(4):1198-209.
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2004: Francis Heather; Glaser Shannon; Ueno Yoshiyuki; Lesage Gene; Marucci Luca; Benedetti Antonio; Taffetani Silvia; Marzioni Marco; Alvaro Domenico; Venter Julie; Reichenbach Ramona; Fava Giammarco; Phinizy Jo Lynne; Alpini Gianfranco
cAMP stimulates the secretory and proliferative capacity of the rat intrahepatic biliary epithelium through changes in the PKA/Src/MEK/ERK1/2 pathway.
Journal of hepatology 2004;41(4):528-37.
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2004: Alpini Gianfranco; Kanno Noriatsu; Phinizy Jo Lynne; Glaser Shannon; Francis Heather; Taffetani Silvia; LeSage Gene
Tauroursodeoxycholate inhibits human cholangiocarcinoma growth via Ca2+-, PKC-, and MAPK-dependent pathways.
American journal of physiology. Gastrointestinal and liver physiology 2004;286(6):G973-82.
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2003: Ueno Yoshiyuki; Alpini Gianfranco; Yahagi Kaichiro; Kanno Noriatsu; Moritoki Yuki; Fukushima Koji; Glaser Shannon; LeSage Gene; Shimosegawa Tooru
Evaluation of differential gene expression by microarray analysis in small and large cholangiocytes isolated from normal mice.
Liver international : official journal of the International Association for the Study of the Liver 2003;23(6):449-59.
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2003: Alpini Gianfranco; Ueno Yoshiyuki; Tadlock Laura; Glaser Shannon S; LeSage Gene; Francis Heather; Taffetani Silvia; Marzioni Marco; Alvaro Domenico; Patel Tushar
Increased susceptibility of cholangiocytes to tumor necrosis factor-alpha cytotoxicity after bile duct ligation.
American journal of physiology. Cell physiology 2003;285(1):C183-94.
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2003: Alpini Gianfranco; Phinizy Jo Lynne; Glaser Shannon; Francis Heather; Benedetti Antonio; Marucci Luca; LeSage Gene
Development and characterization of secretin-stimulated secretion of cultured rat cholangiocytes.
American journal of physiology. Gastrointestinal and liver physiology 2003;284(6):G1066-73.
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2003: Marzioni Marco; LeSage Gene D; Glaser Shannon; Patel Tushar; Marienfeld Carla; Ueno Yoshiyuki; Francis Heather; Alvaro Domenico; Tadlock Laura; Benedetti Antonio; Marucci Luca; Baiocchi Leonardo; Phinizy Jo Lynne; Alpini Gianfranco
Taurocholate prevents the loss of intrahepatic bile ducts due to vagotomy in bile duct-ligated rats.
American journal of physiology. Gastrointestinal and liver physiology 2003;284(5):G837-52.
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2003: Glaser Sharon; Alvaro Domenico; Ueno Yoshiyuki; Francis Heather; Marzioni Marco; Phinizy Jo Lynne; Baumann Brandy; Mancino Maria Grazia; Venter Julie; LeSage Gene; Alpini Gianfranco
Gastrin reverses established cholangiocyte proliferation and enhanced secretin-stimulated ductal secretion of BDL rats by activation of apoptosis through increased expression of Ca2+- dependent PKC isoforms.
Liver international : official journal of the International Association for the Study of the Liver 2003;23(2):78-88.
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2003: Glaser Shannon; Alvaro Domenico; Roskams Tania; Phinizy Jo Lynne; Stoica George; Francis Heather; Ueno Yoshiyuki; Barbaro Barbara; Marzioni Marco; Mauldin Jeremy; Rashid Sobia; Mancino Maria Grazia; LeSage Gene; Alpini Gianfranco
Dopaminergic inhibition of secretin-stimulated choleresis by increased PKC-gamma expression and decrease of PKA activity.
American journal of physiology. Gastrointestinal and liver physiology 2003;284(4):G683-94.
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2003: Baiocchi Leonardo; Alpini Gianfranco; Glaser Shannon; Angelico Mario; Alvaro Domenico; Francis Heather; Marzioni Marco; Phinizy Jo Lynne; Barbaro Barbara; LeSage Gene
Taurohyodeoxycholate- and tauroursodeoxycholate-induced hypercholeresis is augmented in bile duct ligated rats.
Journal of hepatology 2003;38(2):136-47.
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2003: Marucci Luca; Alpini Gianfranco; Glaser Shannon S; Alvaro Domenico; Benedetti Antonio; Francis Heather; Phinizy Jo Lynne; Marzioni Marco; Mauldin Jeremy; Venter Julie; Baumann Brandy; Ugili Laura; LeSage Gene
Taurocholate feeding prevents CCl4-induced damage of large cholangiocytes through PI3-kinase-dependent mechanism.
American journal of physiology. Gastrointestinal and liver physiology 2003;284(2):G290-301.
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2002: Alpini Gianfranco; Glaser Shannon; Alvaro Domenico; Ueno Yoshiyuki; Marzioni Marco; Francis Heather; Baiocchi Leonardo; Stati Tonino; Barbaro Barbara; Phinizy Jo Lynne; Mauldin Jeremy; Lesage Gene
Bile acid depletion and repletion regulate cholangiocyte growth and secretion by a phosphatidylinositol 3-kinase-dependent pathway in rats.
Gastroenterology 2002;123(4):1226-37.
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2002: Lesage Gene D; Marucci Luca; Alvaro Domenico; Glaser Shannon S; Benedetti Antonio; Marzioni Marco; Patel Tushar; Francis Heather; Phinizy Jo Lynne; Alpini Gianfranco
Insulin inhibits secretin-induced ductal secretion by activation of PKC alpha and inhibition of PKA activity.
Hepatology (Baltimore, Md.) 2002;36(3):641-51.
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2002: Marzioni Marco; Glaser Shannon S; Francis Heather; Phinizy Jo Lynne; LeSage Gene; Alpini Gianfranco
Functional heterogeneity of cholangiocytes.
Seminars in liver disease 2002;22(3):227-40.
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2002: Alvaro Domenico; Onori Paolo; Metalli Veronica Drudi; Svegliati-Baroni Gianluca; Folli Franco; Franchitto Antonio; Alpini Gianfranco; Mancino Maria Grazia; Attili Adolfo Francesco; Gaudio Eugenio
Intracellular pathways mediating estrogen-induced cholangiocyte proliferation in the rat.
Hepatology (Baltimore, Md.) 2002;36(2):297-304.
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2002: Alvaro Domenico; Alpini G; Onori P; Franchitto A; Glaser S S; Le Sage G; Folli F; Attili A F; Gaudio E
Alfa and beta estrogen receptors and the biliary tree.
Molecular and cellular endocrinology 2002;193(1-2):105-8.
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2002: Alvaro Domenico; Alpini Gianfranco; Onori Paolo; Franchitto Antonio; Glaser Shannon; Le Sage Gene; Gigliozzi Alessandro; Vetuschi Antonella; Morini Sergio; Attili Adolfo F; Gaudio Eugenio
Effect of ovariectomy on the proliferative capacity of intrahepatic rat cholangiocytes.
Gastroenterology 2002;123(1):336-44.
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2002: Kanno Noriatsu; Lesage Gene; Phinizy Jo Lynne; Glaser Shannon; Francis Heather; Alpini Gianfranco
Stimulation of alpha2-adrenergic receptor inhibits cholangiocarcinoma growth through modulation of Raf-1 and B-Raf activities.
Hepatology (Baltimore, Md.) 2002;35(6):1329-40.
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2002: Alpini Gianfranco; McGill James M; Larusso Nicholas F
The pathobiology of biliary epithelia.
Hepatology (Baltimore, Md.) 2002;35(5):1256-68.
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2002: Alpini Gianfranco; Baiocchi Leonardo; Glaser Shannon; Ueno Yoshiyuki; Marzioni Marco; Francis Heather; Phinizy Jo Lynne; Angelico Mario; Lesage Gene
Ursodeoxycholate and tauroursodeoxycholate inhibit cholangiocyte growth and secretion of BDL rats through activation of PKC alpha.
Hepatology (Baltimore, Md.) 2002;35(5):1041-52.
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2002: Alvaro Domenico; Gigliozzi Alessandro; Marucci Luca; Alpini Gianfranco; Barbaro Barbara; Monterubbianesi Rita; Minetola Lara; Mancino Maria Grazia; Medina Juan F; Attili Adolfo F; Benedetti Antonio
Corticosteroids modulate the secretory processes of the rat intrahepatic biliary epithelium.
Gastroenterology 2002;122(4):1058-69.
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2001: Alpini G; Ueno Y; Glaser S S; Marzioni M; Phinizy J L; Francis H; Lesage G
Bile acid feeding increased proliferative activity and apical bile acid transporter expression in both small and large rat cholangiocytes.
Hepatology (Baltimore, Md.) 2001;34(5):868-76.
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2001: Marzioni M; Glaser S S; Alpini G; LeSage G D
Role of apoptosis in development of primary biliary cirrhosis.
Digestive and liver disease : official journal of the Italian Society of Gastroenterology and the Italian Association for the Study of the Liver 2001;33(7):531-3.
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2001: Kanno N; LeSage G; Glaser S; Alpini G
Regulation of cholangiocyte bicarbonate secretion.
American journal of physiology. Gastrointestinal and liver physiology 2001;281(3):G612-25.
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2001: Lesage G; Glaser S; Ueno Y; Alvaro D; Baiocchi L; Kanno N; Phinizy J L; Francis H; Alpini G
Regression of cholangiocyte proliferation after cessation of ANIT feeding is coupled with increased apoptosis.
American journal of physiology. Gastrointestinal and liver physiology 2001;281(1):G182-90.
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2001: Kanno N; Glaser S; Chowdhury U; Phinizy J L; Baiocchi L; Francis H; LeSage G; Alpini G
Gastrin inhibits cholangiocarcinoma growth through increased apoptosis by activation of Ca2+-dependent protein kinase C-alpha.
Journal of hepatology 2001;34(2):284-91.
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2000: Alvaro D; Alpini G; Onori P; Perego L; Svegliata Baroni G; Franchitto A; Baiocchi L; Glaser S S; Le Sage G; Folli F; Gaudio E
Estrogens stimulate proliferation of intrahepatic biliary epithelium in rats.
Gastroenterology 2000;119(6):1681-91.
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2000: LeSage G; Glaser S; Alpini G
Regulatory mechanisms of ductal bile secretion.
Digestive and liver disease : official journal of the Italian Society of Gastroenterology and the Italian Association for the Study of the Liver 2000;32(7):563-6.
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2000: Alvaro D; Benedetti A; Marucci L; Delle Monache M; Monterubbianesi R; Di Cosimo E; Perego L; Macarri G; Glaser S; Le Sage G; Alpini G
The function of alkaline phosphatase in the liver: regulation of intrahepatic biliary epithelium secretory activities in the rat.
Hepatology (Baltimore, Md.) 2000;32(2):174-84.
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2000: Glaser S; Benedetti A; Marucci L; Alvaro D; Baiocchi L; Kanno N; Caligiuri A; Phinizy J L; Chowdury U; Papa E; LeSage G; Alpini G
Gastrin inhibits cholangiocyte growth in bile duct-ligated rats by interaction with cholecystokinin-B/Gastrin receptors via D-myo-inositol 1,4,5-triphosphate-, Ca(2+)-, and protein kinase C alpha-dependent mechanisms.
Hepatology (Baltimore, Md.) 2000;32(1):17-25.
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2000: Kanno N; LeSage G; Glaser S; Alvaro D; Alpini G
Functional heterogeneity of the intrahepatic biliary epithelium.
Hepatology (Baltimore, Md.) 2000;31(3):555-61.
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1999: Baiocchi L; LeSage G; Glaser S; Alpini G
Regulation of cholangiocyte bile secretion.
Journal of hepatology 1999;31(1):179-91.
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1999: Grappone C; Pinzani M; Parola M; Pellegrini G; Caligiuri A; DeFranco R; Marra F; Herbst H; Alpini G; Milani S
Expression of platelet-derived growth factor in newly formed cholangiocytes during experimental biliary fibrosis in rats.
Journal of hepatology 1999;31(1):100-9.
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1999: LeSagE G; Alvaro D; Benedetti A; Glaser S; Marucci L; Baiocchi L; Eisel W; Caligiuri A; Phinizy J L; Rodgers R; Francis H; Alpini G
Cholinergic system modulates growth, apoptosis, and secretion of cholangiocytes from bile duct-ligated rats.
Gastroenterology 1999;117(1):191-9.
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1999: LeSage G D; Glaser S S; Marucci L; Benedetti A; Phinizy J L; Rodgers R; Caligiuri A; Papa E; Tretjak Z; Jezequel A M; Holcomb L A; Alpini G
Acute carbon tetrachloride feeding induces damage of large but not small cholangiocytes from BDL rat liver.
The American journal of physiology 1999;276(5 Pt 1):G1289-301.
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1999: LeSage G D; Benedetti A; Glaser S; Marucci L; Tretjak Z; Caligiuri A; Rodgers R; Phinizy J L; Baiocchi L; Francis H; Lasater J; Ugili L; Alpini G
Acute carbon tetrachloride feeding selectively damages large, but not small, cholangiocytes from normal rat liver.
Hepatology (Baltimore, Md.) 1999;29(2):307-19.
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1999: Alpini G; Glaser S S; Ueno Y; Rodgers R; Phinizy J L; Francis H; Baiocchi L; Holcomb L A; Caligiuri A; LeSage G D
Bile acid feeding induces cholangiocyte proliferation and secretion: evidence for bile acid-regulated ductal secretion.
Gastroenterology 1999;116(1):179-86.
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1998: Caligiuri A; Glaser S; Rodgers R E; Phinizy J L; Robertson W; Papa E; Pinzani M; Alpini G
Endothelin-1 inhibits secretin-stimulated ductal secretion by interacting with ETA receptors on large cholangiocytes.
The American journal of physiology 1998;275(4 Pt 1):G835-46.
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1998: Alpini G; Glaser S S; Ueno Y; Pham L; Podila P V; Caligiuri A; LeSage G; LaRusso N F
Heterogeneity of the proliferative capacity of rat cholangiocytes after bile duct ligation.
The American journal of physiology 1998;274(4 Pt 1):G767-75.
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1997: Glaser S S; Rodgers R E; Phinizy J L; Robertson W E; Lasater J; Caligiuri A; Tretjak Z; LeSage G D; Alpini G
Gastrin inhibits secretin-induced ductal secretion by interaction with specific receptors on rat cholangiocytes.
The American journal of physiology 1997;273(5 Pt 1):G1061-70.
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1997: Alpini G; Glaser S S; Rodgers R; Phinizy J L; Robertson W E; Lasater J; Caligiuri A; Tretjak Z; LeSage G D
Functional expression of the apical Na+-dependent bile acid transporter in large but not small rat cholangiocytes.
Gastroenterology 1997;113(5):1734-40.
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1997: Alvaro D; Alpini G; Jezequel A M; Bassotti C; Francia C; Fraioli F; Romeo R; Marucci L; Le Sage G; Glaser S S; Benedetti A
Role and mechanisms of action of acetylcholine in the regulation of rat cholangiocyte secretory functions.
The Journal of clinical investigation 1997;100(6):1349-62.
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1997: Alpini G; Elias I; Glaser S S; Rodgers R E; Phinizy J L; Robertson W E; Francis H; Lasater J; Richards M; LeSage G D
gamma-Interferon inhibits secretin-induced choleresis and cholangiocyte proliferation in a murine model of cirrhosis.
Journal of hepatology 1997;27(2):371-80.
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1997: Alpini G; Glaser S; Robertson W; Phinizy J L; Rodgers R E; Caligiuri A; LeSage G
Bile acids stimulate proliferative and secretory events in large but not small cholangiocytes.
The American journal of physiology 1997;273(2 Pt 1):G518-29.
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1997: Alpini G; Glaser S; Robertson W; Rodgers R E; Phinizy J L; Lasater J; LeSage G D
Large but not small intrahepatic bile ducts are involved in secretin-regulated ductal bile secretion.
The American journal of physiology 1997;272(5 Pt 1):G1064-74.
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1996: Lesage G; Glaser S S; Gubba S; Robertson W E; Phinizy J L; Lasater J; Rodgers R E; Alpini G
Regrowth of the rat biliary tree after 70% partial hepatectomy is coupled to increased secretin-induced ductal secretion.
Gastroenterology 1996;111(6):1633-44.
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1996: Alpini G; Roberts S; Kuntz S M; Ueno Y; Gubba S; Podila P V; LeSage G; LaRusso N F
Morphological, molecular, and functional heterogeneity of cholangiocytes from normal rat liver.
Gastroenterology 1996;110(5):1636-43.
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1995: Tietz P S; Alpini G; Pham L D; Larusso N F
Somatostatin inhibits secretin-induced ductal hypercholeresis and exocytosis by cholangiocytes.
The American journal of physiology 1995;269(1 Pt 1):G110-8.
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1994: Roberts S K; Yano M; Ueno Y; Pham L; Alpini G; Agre P; LaRusso N F
Cholangiocytes express the aquaporin CHIP and transport water via a channel-mediated mechanism.
Proceedings of the National Academy of Sciences of the United States of America 1994;91(26):13009-13.
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1994: Alpini G; Phillips J O; Vroman B; LaRusso N F
Recent advances in the isolation of liver cells.
Hepatology (Baltimore, Md.) 1994;20(2):494-514.
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1994: Alpini G; Ulrich C D; Phillips J O; Pham L D; Miller L J; LaRusso N F
Upregulation of secretin receptor gene expression in rat cholangiocytes after bile duct ligation.
The American journal of physiology 1994;266(5 Pt 1):G922-8.
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