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Stuart Aaronson

This is a preview profile on BiomedExperts - the first literature-based scientific social network. It brings the right researchers together and allows them to collaborate online. Collexis and Dell provide the BiomedExperts network of +1.5 Million pre-calculated profiles free of charge to researchers worldwide.

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Co-Publications
Name
23
Pierce, JH
21
Bottaro, Donald
18
Rubin, Jeffrey
17
Miki, Toru
17
LaRochelle, WJ
16
Di Fiore, Pier Paolo
12
Heidaran, MA
11
Bafico, Anna
11
Lee, Sam
9
Ron, David
8
Molloy, Christopher
7
Taylor, WG
7
Liu, Guizhong
5
Macip, Salvador
5
Marchese, Cinzia

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Publications

TOP 3
Benson Erica K; Zhao Bo; Sassoon David A; Lee Sam W; Aaronson Stuart A
Effects of p21 deletion in mouse models of premature aging.
Akiri G; Cherian M M; Vijayakumar S; Liu G; Bafico A; Aaronson S A
Wnt pathway aberrations including autocrine Wnt activation occur at high frequency in human non-small-cell lung carcinoma.
Liu Guizhong; Vijayakumar Sapna; Grumolato Luca; Arroyave Randy; Qiao Huifang; Akiri Gal; Aaronson Stuart A
Canonical Wnts function as potent regulators of osteogenesis by human mesenchymal stem cells.

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All Publications

2009: Benson Erica K; Zhao Bo; Sassoon David A; Lee Sam W; Aaronson Stuart A
Effects of p21 deletion in mouse models of premature aging.
Cell cycle (Georgetown, Tex.) 2009;8(13):2002-4.
2009: Akiri G; Cherian M M; Vijayakumar S; Liu G; Bafico A; Aaronson S A
Wnt pathway aberrations including autocrine Wnt activation occur at high frequency in human non-small-cell lung carcinoma.
Oncogene 2009;28(21):2163-72.
2009: Liu Guizhong; Vijayakumar Sapna; Grumolato Luca; Arroyave Randy; Qiao Huifang; Akiri Gal; Aaronson Stuart A
Canonical Wnts function as potent regulators of osteogenesis by human mesenchymal stem cells.
The Journal of cell biology 2009;185(1):67-75.
2008: Muñoz-Fontela César; Macip Salvador; Martínez-Sobrido Luis; Brown Lauren; Ashour Joseph; García-Sastre Adolfo; Lee Sam W; Aaronson Stuart A
Transcriptional role of p53 in interferon-mediated antiviral immunity.
The Journal of experimental medicine 2008;205(8):1929-38.
2008: Mahale Alka M; Khan Zahid A T; Igarashi Makoto; Nanjangud Gouri J; Qiao Rui Fang; Yao Shen; Lee Sam W; Aaronson Stuart A
Clonal selection in malignant transformation of human fibroblasts transduced with defined cellular oncogenes.
Cancer research 2008;68(5):1417-26.
2007: Liu Xin-Hua; Kirschenbaum Alexander; Yao Shen; Liu Guizhong; Aaronson Stuart A; Levine Alice C
Androgen-induced Wnt signaling in preosteoblasts promotes the growth of MDA-PCa-2b human prostate cancer cells.
Cancer research 2007;67(12):5747-53.
2006: Macip S; Kosoy A; Lee S W; O'Connell M J; Aaronson S A
Oxidative stress induces a prolonged but reversible arrest in p53-null cancer cells, involving a Chk1-dependent G2 checkpoint.
Oncogene 2006;25(45):6037-47.
2005: Bernstein Jonine L; Godbold James H; Raptis George; Watson Mark A; Levinson Brooke; Aaronson Stuart A; Fleming Timothy P
Identification of mammaglobin as a novel serum marker for breast cancer.
Clinical cancer research : an official journal of the American Association for Cancer Research 2005;11(18):6528-35.
2005: Hall Christopher L; Bafico Anna; Dai Jinlu; Aaronson Stuart A; Keller Evan T
Prostate cancer cells promote osteoblastic bone metastases through Wnts.
Cancer research 2005;65(17):7554-60.
2005: Liu Guizhong; Bafico Anna; Aaronson Stuart A
The mechanism of endogenous receptor activation functionally distinguishes prototype canonical and noncanonical Wnts.
Molecular and cellular biology 2005;25(9):3475-82.
2005: Manfredi James J; Dong Jianli; Liu Wen-jun; Resnick-Silverman Lois; Qiao Rui; Chahinian Philippe; Saric Marko; Gibbs Allen R; Phillips James I; Murray J; Axten Charles W; Nolan Robert P; Aaronson Stuart A
Evidence against a role for SV40 in human mesothelioma.
Cancer research 2005;65(7):2602-9.
2005: Aaronson Stuart
Teaching resources. Growth factor and receptor tyrosine kinases.
Science's STKE : signal transduction knowledge environment 2005;2005(272):tr6.
2004: Bafico Anna; Liu Guizhong; Goldin Luba; Harris Violaine; Aaronson Stuart A
An autocrine mechanism for constitutive Wnt pathway activation in human cancer cells.
Cancer cell 2004;6(5):497-506.
2004: Schoenfeld Alan R; Apgar Sarah; Dolios Georgia; Wang Rong; Aaronson Stuart A
BRCA2 is ubiquitinated in vivo and interacts with USP11, a deubiquitinating enzyme that exhibits prosurvival function in the cellular response to DNA damage.
Molecular and cellular biology 2004;24(17):7444-55.
2004: Ohtsuka Takao; Ryu Hoon; Minamishima Yohji A; Macip Salvador; Sagara Junji; Nakayama Keiichi I; Aaronson Stuart A; Lee Sam W
ASC is a Bax adaptor and regulates the p53-Bax mitochondrial apoptosis pathway.
Nature cell biology 2004;6(2):121-8.
2003: Macip Salvador; Igarashi Makoto; Berggren Petra; Yu Jian; Lee Sam W; Aaronson Stuart A
Influence of induced reactive oxygen species in p53-mediated cell fate decisions.
Molecular and cellular biology 2003;23(23):8576-85.
2003: Liu Guizhong; Bafico Anna; Harris Violaine K; Aaronson Stuart A
A novel mechanism for Wnt activation of canonical signaling through the LRP6 receptor.
Molecular and cellular biology 2003;23(16):5825-35.
2003: Dong Jianli; Phelps Robert G; Qiao Rui; Yao Shen; Benard Outhiriaradjou; Ronai Zeev; Aaronson Stuart A
BRAF oncogenic mutations correlate with progression rather than initiation of human melanoma.
Cancer research 2003;63(14):3883-5.
2002: Macip Salvador; Igarashi Makoto; Fang Li; Chen Angus; Pan Zhen-Qiang; Lee Sam W; Aaronson Stuart A
Inhibition of p21-mediated ROS accumulation can rescue p21-induced senescence.
The EMBO journal 2002;21(9):2180-8.
2001: Bafico A; Liu G; Yaniv A; Gazit A; Aaronson S A
Novel mechanism of Wnt signalling inhibition mediated by Dickkopf-1 interaction with LRP6/Arrow.
Nature cell biology 2001;3(7):683-6.
2001: Fang L; Li G; Liu G; Lee S W; Aaronson S A
p53 induction of heparin-binding EGF-like growth factor counteracts p53 growth suppression through activation of MAPK and PI3K/Akt signaling cascades.
The EMBO journal 2001;20(8):1931-9.
2000: Arizti P; Fang L; Park I; Yin Y; Solomon E; Ouchi T; Aaronson S A; Lee S W
Tumor suppressor p53 is required to modulate BRCA1 expression.
Molecular and cellular biology 2000;20(20):7450-9.
2000: Lee S W; Fang L; Igarashi M; Ouchi T; Lu K P; Aaronson S A
Sustained activation of Ras/Raf/mitogen-activated protein kinase cascade by the tumor suppressor p53.
Proceedings of the National Academy of Sciences of the United States of America 2000;97(15):8302-5.
2000: Ouchi T; Lee S W; Ouchi M; Aaronson S A; Horvath C M
Collaboration of signal transducer and activator of transcription 1 (STAT1) and BRCA1 in differential regulation of IFN-gamma target genes.
Proceedings of the National Academy of Sciences of the United States of America 2000;97(10):5208-13.
2000: Lee S W; Reimer C L; Fang L; Iruela-Arispe M L; Aaronson S A
Overexpression of kinase-associated phosphatase (KAP) in breast and prostate cancer and inhibition of the transformed phenotype by antisense KAP expression.
Molecular and cellular biology 2000;20(5):1723-32.
1999: Gazit A; Yaniv A; Bafico A; Pramila T; Igarashi M; Kitajewski J; Aaronson S A
Human frizzled 1 interacts with transforming Wnts to transduce a TCF dependent transcriptional response.
Oncogene 1999;18(44):5959-66.
1999: Blaho J A; Aaronson S A
Convicting a human tumor virus: guilt by association?
Proceedings of the National Academy of Sciences of the United States of America 1999;96(14):7619-21.
1999: Fedi P; Bafico A; Nieto Soria A; Burgess W H; Miki T; Bottaro D P; Kraus M H; Aaronson S A
Isolation and biochemical characterization of the human Dkk-1 homologue, a novel inhibitor of mammalian Wnt signaling.
The Journal of biological chemistry 1999;274(27):19465-72.
1999: Bafico A; Gazit A; Pramila T; Finch P W; Yaniv A; Aaronson S A
Interaction of frizzled related protein (FRP) with Wnt ligands and the frizzled receptor suggests alternative mechanisms for FRP inhibition of Wnt signaling.
The Journal of biological chemistry 1999;274(23):16180-7.
1999: Fang L; Igarashi M; Leung J; Sugrue M M; Lee S W; Aaronson S A
p21Waf1/Cip1/Sdi1 induces permanent growth arrest with markers of replicative senescence in human tumor cells lacking functional p53.
Oncogene 1999;18(18):2789-97.
1999: Reimer C L; Borras A M; Kurdistani S K; Garreau J R; Chung M; Aaronson S A; Lee S W
Altered regulation of cyclin G in human breast cancer and its specific localization at replication foci in response to DNA damage in p53+/+ cells.
The Journal of biological chemistry 1999;274(16):11022-9.
1998: Marmorstein L Y; Ouchi T; Aaronson S A
The BRCA2 gene product functionally interacts with p53 and RAD51.
Proceedings of the National Academy of Sciences of the United States of America 1998;95(23):13869-74.
1998: Levine A C; Liu X H; Greenberg P D; Eliashvili M; Schiff J D; Aaronson S A; Holland J F; Kirschenbaum A
Androgens induce the expression of vascular endothelial growth factor in human fetal prostatic fibroblasts.
Endocrinology 1998;139(11):4672-8.
1998: Kurdistani S K; Arizti P; Reimer C L; Sugrue M M; Aaronson S A; Lee S W
Inhibition of tumor cell growth by RTP/rit42 and its responsiveness to p53 and DNA damage.
Cancer research 1998;58(19):4439-44.
1998: Bafico A; Gazit A; Wu-Morgan S S; Yaniv A; Aaronson S A
Characterization of Wnt-1 and Wnt-2 induced growth alterations and signaling pathways in NIH3T3 fibroblasts.
Oncogene 1998;16(21):2819-25.
1998: Montesano R; Soriano J V; Malinda K M; Ponce M L; Bafico A; Kleinman H K; Bottaro D P; Aaronson S A
Differential effects of hepatocyte growth factor isoforms on epithelial and endothelial tubulogenesis.
Cell growth & differentiation : the molecular biology journal of the American Association for Cancer Research 1998;9(5):355-65.
1998: Igarashi M; Finch P W; Aaronson S A
Characterization of recombinant human fibroblast growth factor (FGF)-10 reveals functional similarities with keratinocyte growth factor (FGF-7).
The Journal of biological chemistry 1998;273(21):13230-5.
1998: Ouchi T; Monteiro A N; August A; Aaronson S A; Hanafusa H
BRCA1 regulates p53-dependent gene expression.
Proceedings of the National Academy of Sciences of the United States of America 1998;95(5):2302-6.
1997: Zimonjic D B; Kelley M J; Rubin J S; Aaronson S A; Popescu N C
Fluorescence in situ hybridization analysis of keratinocyte growth factor gene amplification and dispersion in evolution of great apes and humans.
Proceedings of the National Academy of Sciences of the United States of America 1997;94(21):11461-5.
1997: Sugrue M M; Shin D Y; Lee S W; Aaronson S A
Wild-type p53 triggers a rapid senescence program in human tumor cells lacking functional p53.
Proceedings of the National Academy of Sciences of the United States of America 1997;94(18):9648-53.
1997: Finch P W; He X; Kelley M J; Uren A; Schaudies R P; Popescu N C; Rudikoff S; Aaronson S A; Varmus H E; Rubin J S
Purification and molecular cloning of a secreted, Frizzled-related antagonist of Wnt action.
Proceedings of the National Academy of Sciences of the United States of America 1997;94(13):6770-5.
1997: Shin D Y; Ishibashi T; Choi T S; Chung E; Chung I Y; Aaronson S A; Bottaro D P
A novel human ERK phosphatase regulates H-ras and v-raf signal transduction.
Oncogene 1997;14(22):2633-9.
1997: Diez de Medina S G; Chopin D; El Marjou A; Delouvée A; LaRochelle W J; Hoznek A; Abbou C; Aaronson S A; Thiery J P; Radvanyi F
Decreased expression of keratinocyte growth factor receptor in a subset of human transitional cell bladder carcinomas.
Oncogene 1997;14(3):323-30.
1997: Takayama H; LaRochelle W J; Sharp R; Otsuka T; Kriebel P; Anver M; Aaronson S A; Merlino G
Diverse tumorigenesis associated with aberrant development in mice overexpressing hepatocyte growth factor/scatter factor.
Proceedings of the National Academy of Sciences of the United States of America 1997;94(2):701-6.
1996: Cioce V; Csaky K G; Chan A M; Bottaro D P; Taylor W G; Jensen R; Aaronson S A; Rubin J S
Hepatocyte growth factor (HGF)/NK1 is a naturally occurring HGF/scatter factor variant with partial agonist/antagonist activity.
The Journal of biological chemistry 1996;271(22):13110-5.
1995: Marchese C; Chedid M; Dirsch O R; Csaky K G; Santanelli F; Latini C; LaRochelle W J; Torrisi M R; Aaronson S A
Modulation of keratinocyte growth factor and its receptor in reepithelializing human skin.
The Journal of experimental medicine 1995;182(5):1369-76.
1995: Huang Y; Saez R; Chao L; Santos E; Aaronson S A; Chan A M
A novel insertional mutation in the TC21 gene activates its transforming activity in a human leiomyosarcoma cell line.
Oncogene 1995;11(7):1255-60.
1995: Aroca P; Bottaro D P; Ishibashi T; Aaronson S A; Santos E
Human dual specificity phosphatase VHR activates maturation promotion factor and triggers meiotic maturation in Xenopus oocytes.
The Journal of biological chemistry 1995;270(23):14229-34.
1995: Lorenzi M V; Long J E; Miki T; Aaronson S A
Expression cloning, developmental expression and chromosomal localization of fibroblast growth factor-8.
Oncogene 1995;10(10):2051-5.
1995: Alimandi M; Romano A; Curia M C; Muraro R; Fedi P; Aaronson S A; Di Fiore P P; Kraus M H
Cooperative signaling of ErbB3 and ErbB2 in neoplastic transformation and human mammary carcinomas.
Oncogene 1995;10(9):1813-21.
1995: LaRochelle W J; Dirsch O R; Finch P W; Cheon H G; May M; Marchese C; Pierce J H; Aaronson S A
Specific receptor detection by a functional keratinocyte growth factor-immunoglobulin chimera.
The Journal of cell biology 1995;129(2):357-66.
1995: Miki T; Aaronson S A
Isolation of oncogenes by expression cDNA cloning.
Methods in enzymology 1995;254():196-206.
1994: Ishibashi T; Bottaro D P; Michieli P; Kelley C A; Aaronson S A
A novel dual specificity phosphatase induced by serum stimulation and heat shock.
The Journal of biological chemistry 1994;269(47):29897-902.
1994: Saez R; Chan A M; Miki T; Aaronson S A
Oncogenic activation of human R-ras by point mutations analogous to those of prototype H-ras oncogenes.
Oncogene 1994;9(10):2977-82.
1994: Chan A M; Miki T; Meyers K A; Aaronson S A
A human oncogene of the RAS superfamily unmasked by expression cDNA cloning.
Proceedings of the National Academy of Sciences of the United States of America 1994;91(16):7558-62.
1994: Koji T; Chedid M; Rubin J S; Slayden O D; Csaky K G; Aaronson S A; Brenner R M
Progesterone-dependent expression of keratinocyte growth factor mRNA in stromal cells of the primate endometrium: keratinocyte growth factor as a progestomedin.
The Journal of cell biology 1994;125(2):393-401.
1994: Chedid M; Rubin J S; Csaky K G; Aaronson S A
Regulation of keratinocyte growth factor gene expression by interleukin 1.
The Journal of biological chemistry 1994;269(14):10753-7.
1994: Cheon H G; LaRochelle W J; Bottaro D P; Burgess W H; Aaronson S A
High-affinity binding sites for related fibroblast growth factor ligands reside within different receptor immunoglobulin-like domains.
Proceedings of the National Academy of Sciences of the United States of America 1994;91(3):989-93.
1994: Beeler J F; LaRochelle W J; Chedid M; Tronick S R; Aaronson S A
Prokaryotic expression cloning of a novel human tyrosine kinase.
Molecular and cellular biology 1994;14(2):982-8.
1993: Rubin J S; Bottaro D P; Aaronson S A
Hepatocyte growth factor/scatter factor and its receptor, the c-met proto-oncogene product.
Biochimica et biophysica acta 1993;1155(3):357-71.
1993: May M; Aaronson S A; LaRochelle W J
Platelet-derived growth factor AB heterodimer interchain interactions influence secretion as well as receptor binding and activation.
Biochemistry 1993;32(43):11734-40.
1993: Wang L M; Myers M G; Sun X J; Aaronson S A; White M; Pierce J H
IRS-1: essential for insulin- and IL-4-stimulated mitogenesis in hematopoietic cells.
Science (New York, N.Y.) 1993;261(5128):1591-4.
1993: Cuadrado A; Bruder J T; Heidaran M A; App H; Rapp U R; Aaronson S A
H-ras and raf-1 cooperate in transformation of NIH3T3 fibroblasts.
Oncogene 1993;8(9):2443-8.
1993: LaRochelle W J; Jensen R A; Heidaran M A; May-Siroff M; Wang L M; Aaronson S A; Pierce J H
Inhibition of platelet-derived growth factor autocrine growth stimulation by a monoclonal antibody to the human alpha platelet-derived growth factor receptor.
Cell growth & differentiation : the molecular biology journal of the American Association for Cancer Research 1993;4(7):547-53.
1993: Chan A M; Chedid M; McGovern E S; Popescu N C; Miki T; Aaronson S A
Expression cDNA cloning of a serine kinase transforming gene.
Oncogene 1993;8(5):1329-33.
1993: Heidaran M A; Beeler J F; Yu J C; Ishibashi T; LaRochelle W J; Pierce J H; Aaronson S A
Differences in substrate specificities of alpha and beta platelet-derived growth factor (PDGF) receptors. Correlation with their ability to mediate PDGF transforming functions.
The Journal of biological chemistry 1993;268(13):9287-95.
1993: Bottaro D P; Fortney E; Rubin J S; Aaronson S A
A keratinocyte growth factor receptor-derived peptide antagonist identifies part of the ligand binding site.
The Journal of biological chemistry 1993;268(13):9180-3.
1993: Aaronson S A
Growing families of fibroblast growth factors and receptors.
Japanese journal of cancer research : Gann 1993;84(5):inside front cover.
1993: Wang L M; Keegan A D; Li W; Lienhard G E; Pacini S; Gutkind J S; Myers M G; Sun X J; White M F; Aaronson S A
Common elements in interleukin 4 and insulin signaling pathways in factor-dependent hematopoietic cells.
Proceedings of the National Academy of Sciences of the United States of America 1993;90(9):4032-6.
1993: Kraus M H; Fedi P; Starks V; Muraro R; Aaronson S A
Demonstration of ligand-dependent signaling by the erbB-3 tyrosine kinase and its constitutive activation in human breast tumor cells.
Proceedings of the National Academy of Sciences of the United States of America 1993;90(7):2900-4.
1993: Ron D; Bottaro D P; Finch P W; Morris D; Rubin J S; Aaronson S A
Expression of biologically active recombinant keratinocyte growth factor. Structure/function analysis of amino-terminal truncation mutants.
The Journal of biological chemistry 1993;268(4):2984-8.
1993: Chan A M; Fleming T P; McGovern E S; Chedid M; Miki T; Aaronson S A
Expression cDNA cloning of a transforming gene encoding the wild-type G alpha 12 gene product.
Molecular and cellular biology 1993;13(2):762-8.
1993: Chan A; Rubin J; Bottaro D; Hirschfield D; Chedid M; Aaronson S A
Isoforms of human HGF and their biological activities.
EXS 1993;65():67-79.
1993: Aaronson S A; Miki T; Meyers K; Chan A
Growth factors and malignant transformation.
Advances in experimental medicine and biology 1993;348():7-22.
1992: Ishibashi T; Bottaro D P; Chan A; Miki T; Aaronson S A
Expression cloning of a human dual-specificity phosphatase.
Proceedings of the National Academy of Sciences of the United States of America 1992;89(24):12170-4.
1992: Kelley M J; Pech M; Seuanez H N; Rubin J S; O'Brien S J; Aaronson S A
Emergence of the keratinocyte growth factor multigene family during the great ape radiation.
Proceedings of the National Academy of Sciences of the United States of America 1992;89(19):9287-91.
1992: Molloy C J; Fleming T P; Bottaro D P; Cuadrado A; Aaronson S A
Platelet-derived growth factor stimulation of GTPase-activating protein tyrosine phosphorylation in control and c-H-ras-expressing NIH 3T3 cells correlates with p21ras activation.
Molecular and cellular biology 1992;12(9):3903-9.
1992: LaRochelle W J; Pierce J H; May-Siroff M; Giese N; Aaronson S A
Five PDGF B amino acid substitutions convert PDGF A to a PDGF B-like transforming molecule.
The Journal of biological chemistry 1992;267(24):17074-7.
1992: Fleming T P; Saxena A; Clark W C; Robertson J T; Oldfield E H; Aaronson S A; Ali I U
Amplification and/or overexpression of platelet-derived growth factor receptors and epidermal growth factor receptor in human glial tumors.
Cancer research 1992;52(16):4550-3.
1992: Fleming T P; Matsui T; Heidaran M A; Molloy C J; Artrip J; Aaronson S A
Demonstration of an activated platelet-derived growth factor autocrine pathway and its role in human tumor cell proliferation in vitro.
Oncogene 1992;7(7):1355-9.
1992: Heidaran M A; Yu J C; Jensen R A; Pierce J H; Aaronson S A
A deletion in the extracellular domain of the alpha platelet-derived growth factor (PDGF) receptor differentially impairs PDGF-AA and PDGF-BB binding affinities.
The Journal of biological chemistry 1992;267(5):2884-7.
1992: Miki T; Bottaro D P; Fleming T P; Smith C L; Burgess W H; Chan A M; Aaronson S A
Determination of ligand-binding specificity by alternative splicing: two distinct growth factor receptors encoded by a single gene.
Proceedings of the National Academy of Sciences of the United States of America 1992;89(1):246-50.
1991: Chan A M; Rubin J S; Bottaro D P; Hirschfield D W; Chedid M; Aaronson S A
Identification of a competitive HGF antagonist encoded by an alternative transcript.
Science (New York, N.Y.) 1991;254(5036):1382-5.
1991: Aaronson S A
Growth factors and cancer.
Science (New York, N.Y.) 1991;254(5035):1146-53.
1991: Heidaran M A; Pierce J H; Yu J C; Lombardi D; Artrip J E; Fleming T P; Thomason A; Aaronson S A
Role of alpha beta receptor heterodimer formation in beta platelet-derived growth factor (PDGF) receptor activation by PDGF-AB.
The Journal of biological chemistry 1991;266(30):20232-7.
1991: LaRochelle W J; May-Siroff M; Robbins K C; Aaronson S A
A novel mechanism regulating growth factor association with the cell surface: identification of a PDGF retention domain.
Genes & development 1991;5(7):1191-9.
1991: Pierce J H; Arnstein P; DiMarco E; Artrip J; Kraus M H; Lonardo F; Di Fiore P P; Aaronson S A
Oncogenic potential of erbB-2 in human mammary epithelial cells.
Oncogene 1991;6(7):1189-94.
1991: Yu J C; Heidaran M A; Pierce J H; Gutkind J S; Lombardi D; Ruggiero M; Aaronson S A
Tyrosine mutations within the alpha platelet-derived growth factor receptor kinase insert domain abrogate receptor-associated phosphatidylinositol-3 kinase activity without affecting mitogenic or chemotactic signal transduction.
Molecular and cellular biology 1991;11(7):3780-5.
1991: Miki T; Fleming T P; Crescenzi M; Molloy C J; Blam S B; Reynolds S H; Aaronson S A
Development of a highly efficient expression cDNA cloning system: application to oncogene isolation.
Proceedings of the National Academy of Sciences of the United States of America 1991;88(12):5167-71.
1991: Smith E A; Seldin M F; Martinez L; Watson M L; Choudhury G G; Lalley P A; Pierce J; Aaronson S; Barker J; Naylor S L
Mouse platelet-derived growth factor receptor alpha gene is deleted in W19H and patch mutations on chromosome 5.
Proceedings of the National Academy of Sciences of the United States of America 1991;88(11):4811-5.
1991: Ron D; Zannini M; Lewis M; Wickner R B; Hunt L T; Graziani G; Tronick S R; Aaronson S A; Eva A
A region of proto-dbl essential for its transforming activity shows sequence similarity to a yeast cell cycle gene, CDC24, and the human breakpoint cluster gene, bcr.
The New biologist 1991;3(4):372-9.
1991: Bottaro D P; Rubin J S; Faletto D L; Chan A M; Kmiecik T E; Vande Woude G F; Aaronson S A
Identification of the hepatocyte growth factor receptor as the c-met proto-oncogene product.
Science (New York, N.Y.) 1991;251(4995):802-4.
1991: Miki T; Fleming T P; Bottaro D P; Rubin J S; Ron D; Aaronson S A
Expression cDNA cloning of the KGF receptor by creation of a transforming autocrine loop.
Science (New York, N.Y.) 1991;251(4989):72-5.
1991: Heidaran M A; Pierce J H; Lombardi D; Ruggiero M; Gutkind J S; Matsui T; Aaronson S A
Deletion or substitution within the alpha platelet-derived growth factor receptor kinase insert domain: effects on functional coupling with intracellular signaling pathways.
Molecular and cellular biology 1991;11(1):134-42.
1991: Aaronson S A
Influences of growth factors and their signaling pathways in malignancy.
Harvey lectures 1991;87():17-34.
1991: Aaronson S A; Bottaro D P; Miki T; Ron D; Finch P W; Fleming T P; Ahn J; Taylor W G; Rubin J S
Keratinocyte growth factor. A fibroblast growth factor family member with unusual target cell specificity.
Annals of the New York Academy of Sciences 1991;638():62-77.
1990: Aaronson S A; Rubin J S; Finch P W; Wong J; Marchese C; Falco J; Taylor W G; Kraus M H
Growth factor-regulated pathways in epithelial cell proliferation.
The American review of respiratory disease 1990;142(6 Pt 2):S7-10.
1990: Crescenzi M; Fleming T P; Lassar A B; Weintraub H; Aaronson S A
MyoD induces growth arrest independent of differentiation in normal and transformed cells.
Proceedings of the National Academy of Sciences of the United States of America 1990;87(21):8442-6.
1990: Heidaran M A; Pierce J H; Jensen R A; Matsui T; Aaronson S A
Chimeric alpha- and beta-platelet-derived growth factor (PDGF) receptors define three immunoglobulin-like domains of the alpha-PDGF receptor that determine PDGF-AA binding specificity.
The Journal of biological chemistry 1990;265(31):18741-4.
1990: Lonardo F; Di Marco E; King C R; Pierce J H; Segatto O; Aaronson S A; Di Fiore P P
The normal erbB-2 product is an atypical receptor-like tyrosine kinase with constitutive activity in the absence of ligand.
The New biologist 1990;2(11):992-1003.
1990: Giese N; LaRochelle W J; May-Siroff M; Robbins K C; Aaronson S A
A small v-sis/platelet-derived growth factor (PDGF) B-protein domain in which subtle conformational changes abrogate PDGF receptor interaction and transforming activity.
Molecular and cellular biology 1990;10(10):5496-501.
1990: Heidaran M A; Fleming T P; Bottaro D P; Bell G I; Di Fiore P P; Aaronson S A
Transformation of NIH3T3 fibroblasts by an expression vector for the human epidermal growth factor precursor.
Oncogene 1990;5(8):1265-70.
1990: Kruh G D; Perego R; Miki T; Aaronson S A
The complete coding sequence of arg defines the Abelson subfamily of cytoplasmic tyrosine kinases.
Proceedings of the National Academy of Sciences of the United States of America 1990;87(15):5802-6.
1990: Bottaro D P; Rubin J S; Ron D; Finch P W; Florio C; Aaronson S A
Characterization of the receptor for keratinocyte growth factor. Evidence for multiple fibroblast growth factor receptors.
The Journal of biological chemistry 1990;265(22):12767-70.
1990: Marchese C; Rubin J; Ron D; Faggioni A; Torrisi M R; Messina A; Frati L; Aaronson S A
Human keratinocyte growth factor activity on proliferation and differentiation of human keratinocytes: differentiation response distinguishes KGF from EGF family.
Journal of cellular physiology 1990;144(2):326-32.
1990: Aaronson S A; Pierce J H
Molecular mimicry of growth factors by products of tumor viruses.
Cancer cells (Cold Spring Harbor, N.Y. : 1989) 1990;2(7):212-4.
1990: Di Fiore P P; Segatto O; Lonardo F; Fazioli F; Pierce J H; Aaronson S A
The carboxy-terminal domains of erbB-2 and epidermal growth factor receptor exert different regulatory effects on intrinsic receptor tyrosine kinase function and transforming activity.
Molecular and cellular biology 1990;10(6):2749-56.
1990: LaRochelle W J; Giese N; May-Siroff M; Robbins K C; Aaronson S A
Molecular localization of the transforming and secretory properties of PDGF A and PDGF B.
Science (New York, N.Y.) 1990;248(4962):1541-4.
1990: Di Fiore P P; Segatto O; Taylor W G; Aaronson S A; Pierce J H
EGF receptor and erbB-2 tyrosine kinase domains confer cell specificity for mitogenic signaling.
Science (New York, N.Y.) 1990;248(4951):79-83.
1990: Di Marco E; Pierce J H; Aaronson S A; Di Fiore P P
Mechanisms by which EGF receptor and TGF alpha contribute to malignant transformation.
Natural immunity and cell growth regulation 1990;9(3):209-21.
1990: Larochelle W J; Giese N; May-Siroff M; Robbins K C; Aaronson S A
Chimeric molecules map and dissociate the potent transforming and secretory properties of PDGF A and PDGF B.
Journal of cell science. Supplement 1990;13():31-42.
1989: Kraus M H; Issing W; Miki T; Popescu N C; Aaronson S A
Isolation and characterization of ERBB3, a third member of the ERBB/epidermal growth factor receptor family: evidence for overexpression in a subset of human mammary tumors.
Proceedings of the National Academy of Sciences of the United States of America 1989;86(23):9193-7.
1989: Molloy C J; Bottaro D P; Fleming T P; Marshall M S; Gibbs J B; Aaronson S A
PDGF induction of tyrosine phosphorylation of GTPase activating protein.
Nature 1989;342(6250):711-4.
1989: Matsui T; Pierce J H; Fleming T P; Greenberger J S; LaRochelle W J; Ruggiero M; Aaronson S A
Independent expression of human alpha or beta platelet-derived growth factor receptor cDNAs in a naive hematopoietic cell leads to functional coupling with mitogenic and chemotactic signaling pathways.
Proceedings of the National Academy of Sciences of the United States of America 1989;86(21):8314-8.
1989: Miki T; Matsui T; Heidaran M A; Aaronson S A
An efficient directional cloning system to construct cDNA libraries containing full-length inserts at high frequency.
Gene 1989;83(1):137-46.
1989: Fleming T P; Matsui T; Molloy C J; Robbins K C; Aaronson S A
Autocrine mechanism for v-sis transformation requires cell surface localization of internally activated growth factor receptors.
Proceedings of the National Academy of Sciences of the United States of America 1989;86(20):8063-7.
1989: Ron D; Graziani G; Aaronson S A; Eva A
The N-terminal region of proto-dbl down regulates its transforming activity.
Oncogene 1989;4(9):1067-72.
1989: LaRochelle W J; Robbins K C; Aaronson S A
Immunochemical localization of the epitope for a monoclonal antibody that neutralizes human platelet-derived growth factor mitogenic activity.
Molecular and cellular biology 1989;9(8):3538-42.
1989: Finch P W; Rubin J S; Miki T; Ron D; Aaronson S A
Human KGF is FGF-related with properties of a paracrine effector of epithelial cell growth.
Science (New York, N.Y.) 1989;245(4919):752-5.
1989: Di Marco E; Pierce J H; Fleming T P; Kraus M H; Molloy C J; Aaronson S A; Di Fiore P P
Autocrine interaction between TGF alpha and the EGF-receptor: quantitative requirements for induction of the malignant phenotype.
Oncogene 1989;4(7):831-8.
1989: Giese N; May-Siroff M; LaRochelle W J; van Wyke Coelingh K; Aaronson S A
Expression and purification of biologically active v-sis/platelet-derived growth factor B protein by using a baculovirus vector system.
Journal of virology 1989;63(7):3080-6.
1989: Moscat J; Fleming T P; Molloy C J; Lopez-Barahona M; Aaronson S A
The calcium signal for Balb/MK keratinocyte terminal differentiation induces sustained alterations in phosphoinositide metabolism without detectable protein kinase C activation.
The Journal of biological chemistry 1989;264(19):11228-35.
1989: Pech M; Gazit A; Arnstein P; Aaronson S A
Generation of fibrosarcomas in vivo by a retrovirus that expresses the normal B chain of platelet-derived growth factor and mimics the alternative splice pattern of the v-sis oncogene.
Proceedings of the National Academy of Sciences of the United States of America 1989;86(8):2693-7.
1989: Rubin J S; Osada H; Finch P W; Taylor W G; Rudikoff S; Aaronson S A
Purification and characterization of a newly identified growth factor specific for epithelial cells.
Proceedings of the National Academy of Sciences of the United States of America 1989;86(3):802-6.
1989: Pech M; Rao C D; Robbins K C; Aaronson S A
Functional identification of regulatory elements within the promoter region of platelet-derived growth factor 2.
Molecular and cellular biology 1989;9(2):396-405.
1989: Matsui T; Heidaran M; Miki T; Popescu N; La Rochelle W; Kraus M; Pierce J; Aaronson S
Isolation of a novel receptor cDNA establishes the existence of two PDGF receptor genes.
Science (New York, N.Y.) 1989;243(4892):800-4.
1989: Aaronson S A; Falco J P; Taylor W G; Cech A C; Marchese C; Finch P W; Rubin J; Weissman B E; Di Fiore P P
Pathways in which growth factors and oncogenes interact in epithelial cell mitogenic signal transduction.
Annals of the New York Academy of Sciences 1989;567():122-9.
1988: Segatto O; King C R; Pierce J H; Di Fiore P P; Aaronson S A
Different structural alterations upregulate in vitro tyrosine kinase activity and transforming potency of the erbB-2 gene.
Molecular and cellular biology 1988;8(12):5570-4.
1988: Beckmann M P; Betsholtz C; Heldin C H; Westermark B; Di Marco E; Di Fiore P P; Robbins K C; Aaronson S A
Comparison of biological properties and transforming potential of human PDGF-A and PDGF-B chains.
Science (New York, N.Y.) 1988;241(4871):1346-9.
1988: Moscat J; Molloy C J; Fleming T P; Aaronson S A
Epidermal growth factor activates phosphoinositide turnover and protein kinase C in BALB/MK keratinocytes.
Molecular endocrinology (Baltimore, Md.) 1988;2(9):799-805.
1988: Blam S B; Mitchell R; Tischer E; Rubin J S; Silva M; Silver S; Fiddes J C; Abraham J A; Aaronson S A
Addition of growth hormone secretion signal to basic fibroblast growth factor results in cell transformation and secretion of aberrant forms of the protein.
Oncogene 1988;3(2):129-36.
1988: Ron D; Tronick S R; Aaronson S A; Eva A
Molecular cloning and characterization of the human dbl proto-oncogene: evidence that its overexpression is sufficient to transform NIH/3T3 cells.
The EMBO journal 1988;7(8):2465-73.
1988: Falco J P; Taylor W G; Di Fiore P P; Weissman B E; Aaronson S A
Interactions of growth factors and retroviral oncogenes with mitogenic signal transduction pathways of Balb/MK keratinocytes.
Oncogene 1988;2(6):573-8.
1988: Kawakami T; Kawakami Y; Aaronson S A; Robbins K C
Acquisition of transforming properties by FYN, a normal SRC-related human gene.
Proceedings of the National Academy of Sciences of the United States of America 1988;85(11):3870-4.
1988: Eva A; Vecchio G; Rao C D; Tronick S R; Aaronson S A
The predicted DBL oncogene product defines a distinct class of transforming proteins.
Proceedings of the National Academy of Sciences of the United States of America 1988;85(7):2061-5.
1988: Pierce J H; Ruggiero M; Fleming T P; Di Fiore P P; Greenberger J S; Varticovski L; Schlessinger J; Rovera G; Aaronson S A
Signal transduction through the EGF receptor transfected in IL-3-dependent hematopoietic cells.
Science (New York, N.Y.) 1988;239(4840):628-31.
1988: Di Fiore P P; Falco J; Borrello I; Weissman B; Aaronson S A
The calcium signal for BALB/MK keratinocyte terminal differentiation counteracts epidermal growth factor (EGF) very early in the EGF-induced proliferative pathway.
Molecular and cellular biology 1988;8(2):557-63.
1988: Rao C D; Pech M; Robbins K C; Aaronson S A
The 5' untranslated sequence of the c-sis/platelet-derived growth factor 2 transcript is a potent translational inhibitor.
Molecular and cellular biology 1988;8(1):284-92.
1988: Tronick S R; Aaronson S A
Oncogenes, growth regulation, and cancer.
Advances in second messenger and phosphoprotein research 1988;21():201-14.
1988: Kraus M H; Pierce J H; Fleming T P; Robbins K C; Di Fiore P P; Aaronson S A
Mechanisms by which genes encoding growth factors and growth factor receptors contribute to malignant transformation.
Annals of the New York Academy of Sciences 1988;551():320-35; discussion 336.
1988: Finzi E; Kilkenny A; Strickland J E; Balaschak M; Bringman T; Derynck R; Aaronson S; Yuspa S H
TGF alpha stimulates growth of skin papillomas by autocrine and paracrine mechanisms but does not cause neoplastic progression.
Molecular carcinogenesis 1988;1(1):7-12.
1987: Lacal J C; Fleming T P; Warren B S; Blumberg P M; Aaronson S A
Involvement of functional protein kinase C in the mitogenic response to the H-ras oncogene product.
Molecular and cellular biology 1987;7(11):4146-9.
1987: Lacal J C; Moscat J; Aaronson S A
Novel source of 1,2-diacylglycerol elevated in cells transformed by Ha-ras oncogene.
Nature 1987;330(6145):269-72.
1987: Lacal J C; de la Peña P; Moscat J; Garcia-Barreno P; Anderson P S; Aaronson S A
Rapid stimulation of diacylglycerol production in Xenopus oocytes by microinjection of H-ras p21.
Science (New York, N.Y.) 1987;238(4826):533-6.
1987: Di Fiore P P; Pierce J H; Kraus M H; Segatto O; King C R; Aaronson S A
erbB-2 is a potent oncogene when overexpressed in NIH/3T3 cells.
Science (New York, N.Y.) 1987;237(4811):178-82.
1987: Finzi E; Fleming T; Segatto O; Pennington C Y; Bringman T S; Derynck R; Aaronson S A
The human transforming growth factor type alpha coding sequence is not a direct-acting oncogene when overexpressed in NIH 3T3 cells.
Proceedings of the National Academy of Sciences of the United States of America 1987;84(11):3733-7.
1987: Igarashi H; Rao C D; Siroff M; Leal F; Robbins K C; Aaronson S A
Detection of PDGF-2 homodimers in human tumor cells.
Oncogene 1987;1(1):79-85.
1987: Eva A; Vecchio G; Diamond M; Tronick S R; Ron D; Cooper G M; Aaronson S A
Independently activated dbl oncogenes exhibit similar yet distinct structural alterations.
Oncogene 1987;1(4):355-60.
1987: Eva A; Pierce J H; Aaronson S A
Interactions of retroviral and cellular transforming genes with hematopoietic cells.
Annals of the New York Academy of Sciences 1987;511():148-70.
1986: Pasti G; Lacal J C; Warren B S; Aaronson S A; Blumberg P M
Loss of mouse fibroblast cell response to phorbol esters restored by microinjected protein kinase C.
Nature 1986;324(6095):375-7.
1986: Rao C D; Igarashi H; Pech M W; Robbins K C; Aaronson S A
Oncogenic potential of the human platelet-derived growth factor transcriptional unit.
Cold Spring Harbor symposia on quantitative biology 1986;51 Pt 2():959-66.
1986: Aaronson S A; Igarashi H; Rao C D; Finzi E; Fleming T P; Segatto O; Robbins K C
Role of genes for normal growth factors in human malignancy.
Princess Takamatsu symposia 1986;17():95-108.
1986: Robbins K C; King C R; Giese N A; Leal F; Igarashi H; Aaronson S A
Involvement of oncogene-coded growth factors in the neoplastic process.
Gene amplification and analysis 1986;4():161-76.
1985: Srivastava S K; Lacal J C; Reynolds S H; Aaronson S A
Antibody of predetermined specificity to a carboxy-terminal region of H-ras gene products inhibits their guanine nucleotide-binding function.
Molecular and cellular biology 1985;5(11):3316-9.

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