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Meindert Danhof

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Venkatesh Pilla Reddy; Ahmed Abbas Suleiman; An Vermeulen; Meindert Danhof; Rik de Greef; Geny M M Groothuis; Martin Johnson; Magdalena Kozielska; Jing Liu; Johannes H Proost
Pharmacokinetic-pharmacodynamic modelling of antipsychotic drugs in patients with schizophrenia: Part II: The use of subscales of the PANSS score.
Venkatesh Pilla Reddy; Ahmed Abbas Suleiman; An Vermeulen; Meindert Danhof; Rik de Greef; Geny M M Groothuis; Martin Johnson; Magdalena Kozielska; Jing Liu; Johannes H Proost
Pharmacokinetic-pharmacodynamic modeling of antipsychotic drugs in patients with schizophrenia Part I: The use of PANSS total score and clinical utility.
Ibrahim Ince; Catherijne A J Knibbe; Meindert Danhof; Saskia N de Wildt
Developmental Changes in the Expression and Function of Cytochrome P450 3A Isoforms: Evidence from In Vitro and In Vivo Investigations.

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2013: Venkatesh Pilla Reddy; Ahmed Abbas Suleiman; An Vermeulen; Meindert Danhof; Rik de Greef; Geny M M Groothuis; Martin Johnson; Magdalena Kozielska; Jing Liu; Johannes H Proost
Pharmacokinetic-pharmacodynamic modelling of antipsychotic drugs in patients with schizophrenia: Part II: The use of subscales of the PANSS score.
Schizophrenia research 2013;146(1-3):153-61.
2013: Venkatesh Pilla Reddy; Ahmed Abbas Suleiman; An Vermeulen; Meindert Danhof; Rik de Greef; Geny M M Groothuis; Martin Johnson; Magdalena Kozielska; Jing Liu; Johannes H Proost
Pharmacokinetic-pharmacodynamic modeling of antipsychotic drugs in patients with schizophrenia Part I: The use of PANSS total score and clinical utility.
Schizophrenia research 2013;146(1-3):144-52.
2013: Ibrahim Ince; Catherijne A J Knibbe; Meindert Danhof; Saskia N de Wildt
Developmental Changes in the Expression and Function of Cytochrome P450 3A Isoforms: Evidence from In Vitro and In Vivo Investigations.
Clinical pharmacokinetics 2013;52(5):333-45.
2013: Magdalena Kozielska; Jing Liu; Venkatesh Pilla Reddy; Meindert Danhof; Filip de Ridder; Geny M M Groothuis; Martin Johnson; An Vermeulen; Johannes H Proost
Sensitivity of individual items of the Positive and Negative Syndrome Scale (PANSS) and items subgroups to differentiate between placebo and drug treatment in schizophrenia.
Schizophrenia research 2013;146(1-3):53-8.
2013: Teun M Post; Stephan Schmidt; Rik de Greef; Thomas Kerbusch; Lambertus A Peletier; Meindert Danhof
Application of a mechanism-based disease systems model for osteoporosis to clinical data.
Journal of pharmacokinetics and pharmacodynamics 2013;40(2):143-56.
2013: Frances Stringer; Richard Urquhart; Joost DeJongh; Aziz Karim; Bart A Ploeger; Graham Scott; Meindert Danhof
Evaluation of the impact of UGT polymorphism on the pharmacokinetics and pharmacodynamics of the novel PPAR agonist sipoglitazar.
Journal of clinical pharmacology 2013;53(3):256-63.
2013: Imke Heleen Bartelink; Svetlana V Belitser; Meindert Danhof; Anne J de Pagter; Toine C G Egberts; Catherijne A J Knibbe; Jaap Jan Boelens
Immune reconstitution kinetics as an early predictor for mortality using various hematopoietic stem cell sources in children.
Biology of blood and marrow transplantation : journal of the American Society for Blood and Marrow Transplantation 2013;19(2):305-13.
2013: Roosmarijn F W De Cock; Jan de Hoon; Catherijne A J Knibbe; Aida Kulo; Rene Verbesselt; Meindert Danhof; Karel Allegaert
Developmental pharmacokinetics of propylene glycol in preterm and term neonates.
British journal of clinical pharmacology 2013;75(1):162-71.
2012: Rogério Gaspar; Hans H Linden; Andreas Link; Eva-Maria Muchitsch; Per Ohrngren; Milena Jadrijevic-Mladar Takac; Clive G Wilson; Buket Aksu; Alain Cuine; Meindert Danhof; Lennart Dencker
Towards a European strategy for medicines research (2014-2020): The EUFEPS position paper on Horizon 2020.
European journal of pharmaceutical sciences : official journal of the European Federation for Pharmaceutical Sciences 2012;47(5):979-87.
2012: A Taneja; J Nyberg; Meindert Danhof; E C M de Lange; Oscar Della-Pasqua
Application of ED-optimality to screening experiments for analgesic compounds in an experimental model of neuropathic pain.
Journal of pharmacokinetics and pharmacodynamics 2012;39(6):673-81.
2012: A Taneja; J Nyberg; Meindert Danhof; Oscar Della-Pasqua
Optimised protocol design for the screening of analgesic compounds in neuropathic pain.
Journal of pharmacokinetics and pharmacodynamics 2012;39(6):661-71.
2012: Elke H J Krekels; Dick Tibboel; Meindert Danhof; Catherijne A J Knibbe
Prediction of morphine clearance in the paediatric population : how accurate are the available pharmacokinetic models?
Clinical pharmacokinetics 2012;51(11):695-709.
2012: Imke H Bartelink; Marc Bierings; Jaap Jan Boelens; Robert Chiesa; Geoff D E Cuvelier; Meindert Danhof; Toine C G Egberts; Mary A Slatter; Charlotte van Kesteren; Robert F Wynn; Catherijne A J Knibbe
Predictive performance of a busulfan pharmacokinetic model in children and young adults.
Therapeutic drug monitoring 2012;34(5):574-83.
2012: Jasper Stevens; Piet H van Der Graaf; Meindert Danhof; Margareta Hammarlund-Udenaes; Gunilla Osswald; Bart A Ploeger; Elizabeth C M de Lange
Mechanism-based PK-PD model for the prolactin biological system response following an acute dopamine inhibition challenge: quantitative extrapolation to humans.
Journal of pharmacokinetics and pharmacodynamics 2012;39(5):463-77.
2012: Joost Westerhout; Meindert Danhof; Bart A Ploeger; Jean Smeets; Elizabeth C M de Lange
Physiologically based pharmacokinetic modeling to investigate regional brain distribution kinetics in rats.
The AAPS journal 2012;14(3):543-53.
2012: Massimo Cella; Meindert Danhof; Saskia N de Wildt; Catherijne A J Knibbe; Joop Van Gerven; Oscar Della-Pasqua
Scaling of pharmacokinetics across paediatric populations: the lack of interpolative power of allometric models.
British journal of clinical pharmacology 2012;74(3):525-35.
2012: Ibrahim Ince; Meindert Danhof; Saskia N de Wildt; Daryl J Murry; Mariska Y M Peeters; Dick Tibboel; Catherijne A J Knibbe
Critical illness is a major determinant of midazolam clearance in children aged 1 month to 17 years.
Therapeutic drug monitoring 2012;34(4):381-9.
2012: Amit Taneja; Vincenzo Luca Di Iorio; Meindert Danhof; Oscar Della-Pasqua
Translation of drug effects from experimental models of neuropathic pain and analgesia to humans.
Drug discovery today 2012;17(15-16):837-49.
2012: Massimo Cella; Meindert Danhof; Oscar Della-Pasqua
Adaptive trials in paediatric development: dealing with heterogeneity and uncertainty in pharmacokinetic differences in children.
British journal of clinical pharmacology 2012;74(2):346-53.
2012: Elke H J Krekels; Dick Tibboel; Meindert Danhof; Catherijne A J Knibbe
Ontogeny of hepatic glucuronidation; methods and results.
Current drug metabolism 2012;13(6):728-43.
2012: Magdalena Kozielska; Cheryl Li; Venkatesh Pilla Reddy; Meindert Danhof; Rik de Greef; Sarah Grimwood; Geny M M Groothuis; Martin Johnson; An Vermeulen; Johannes H Proost
Pharmacokinetic-pharmacodynamic modeling of the D₂ and 5-HT (2A) receptor occupancy of risperidone and paliperidone in rats.
Pharmaceutical research 2012;29(7):1932-48.
2012: Chenguang Wang; Heleen J Blussé van Oud-Alblas; Karel Allegaert; Meindert Danhof; Elke H J Krekels; Mariska Y M Peeters; Dick Tibboel; Catherijne A J Knibbe
A bodyweight-dependent allometric exponent for scaling clearance across the human life-span.
Pharmaceutical research 2012;29(6):1570-81.
2012: Imke H Bartelink; Marc Bierings; Jaap Jan Boelens; R G M Bredius; Meindert Danhof; Antoine C G Egberts; George Hempel; Christa E Nath; Peter J Shaw; Chenguang Wang; Juliette Zwaveling; Catherijne A J Knibbe
Body weight-dependent pharmacokinetics of busulfan in paediatric haematopoietic stem cell transplantation patients: towards individualized dosing.
Clinical pharmacokinetics 2012;51(5):331-45.
2012: Venkatesh Pilla Reddy; Ahmed Abbas Suleiman; An Vermeulen; Meindert Danhof; Rik de Greef; Geny M M Groothuis; Martin Johnson; Magdalena Kozielska; Jing Liu; Johannes H Proost
Modelling and simulation of the Positive and Negative Syndrome Scale (PANSS) time course and dropout hazard in placebo arms of schizophrenia clinical trials.
Clinical pharmacokinetics 2012;51(4):261-75.
2012: M Cella; Meindert Danhof; Oscar Della-Pasqua
Bridging strategies for drug combinations in pediatric indications.
Clinical pharmacology and therapeutics 2012;91(4):726-33.
2012: M Cella; Meindert Danhof; F Kloprogge; Oscar Della-Pasqua
Dosing rationale for fixed-dose combinations in children: shooting from the hip?
Clinical pharmacology and therapeutics 2012;91(4):718-25.
2012: Ashley Strougo; Stefan Willmann; Ashraf Yassen; Meindert Danhof; Thomas Eissing; Jan Freijer
First dose in children: physiological insights into pharmacokinetic scaling approaches and their implications in paediatric drug development.
Journal of pharmacokinetics and pharmacodynamics 2012;39(2):195-203.
2012: Roosmarijn F W De Cock; Matthijs de Hoog; Karel Allegaert; Meindert Danhof; Michiel F Schreuder; Catherine M T Sherwin; Johannes N van den Anker; Catherijne A J Knibbe
Maturation of the glomerular filtration rate in neonates, as reflected by amikacin clearance.
Clinical pharmacokinetics 2012;51(2):105-17.
2012: Paulien Gm Ravenstijn; Meindert Danhof; Henk-Jan Drenth; Michael J O'Neill; Elizabeth Cm de Lange
Evaluation of blood-brain barrier transport and CNS drug metabolism in diseased and control brain after intravenous L-DOPA in a unilateral rat model of Parkinson's disease.
Fluids and barriers of the CNS 2012;9():4.
2011: A S Y Chain; Meindert Danhof; K M Krudys; Oscar Della-Pasqua
Assessing the probability of drug-induced QTc-interval prolongation during clinical drug development.
Clinical pharmacology and therapeutics 2011;90(6):867-75.
2011: Stephan Schmidt; Massoud A Boroujerdi; Lambertus A Peletier; Teun M Post; Meindert Danhof
Coping with time scales in disease systems analysis: application to bone remodeling.
Journal of pharmacokinetics and pharmacodynamics 2011;38(6):873-900.
2011: Jasper Stevens; Piet H van Der Graaf; Meindert Danhof; Bart A Ploeger; Elizabeth C M de Lange
Systemic and direct nose-to-brain transport pharmacokinetic model for remoxipride after intravenous and intranasal administration.
Drug metabolism and disposition: the biological fate of chemicals 2011;39(12):2275-82.
2011: Simone van Kralingen; Bert van Ramshorst; René J Wiezer; Mariska Y M Peeters; Eric P van Dongen; Meindert Danhof; Vera H M Deneer; Jeroen Diepstraten; Catherijne A J Knibbe
Population pharmacokinetics and pharmacodynamics of propofol in morbidly obese patients.
Clinical pharmacokinetics 2011;50(11):739-50.
2011: Martin Johnson; Magdalena Kozielska; Cheryl Li; Venkatesh Pilla Reddy; Meindert Danhof; Rik de Greef; Sarah Grimwood; Geny M M Groothuis; An Vermeulen; Johannes H Proost
Mechanism-based pharmacokinetic-pharmacodynamic modeling of the dopamine D2 receptor occupancy of olanzapine in rats.
Pharmaceutical research 2011;28(10):2490-504.
2011: Joost Westerhout; Meindert Danhof; Elizabeth C M de Lange
Preclinical prediction of human brain target site concentrations: considerations in extrapolating to the clinical setting.
Journal of pharmaceutical sciences 2011;100(9):3577-93.
2011: Massimo Cella; Meindert Danhof; Evelyne Jacqz-Aigrain; Wei Zhao; David Burger; Oscar Della Pasqua
Paediatric drug development: are population models predictive of pharmacokinetics across paediatric populations?
British journal of clinical pharmacology 2011;72(3):454-64.
2011: Catherijne A J Knibbe; Meindert Danhof
Individualized dosing regimens in children based on population PKPD modelling: are we ready for it?
International journal of pharmaceutics 2011;415(1-2):9-14.
2011: Venkatesh Pilla Reddy; An Vermeulen; Meindert Danhof; Rik de Greef; Geny M M Groothuis; Martin Johnson; Magdalena Kozielska; Jing Liu; Johannes H Proost
Structural models describing placebo treatment effects in schizophrenia and other neuropsychiatric disorders.
Clinical pharmacokinetics 2011;50(7):429-50.
2011: Ashley Strougo; Ashraf Yassen; Meindert Danhof; Walter Krauwinkel; Jan Freijer
A semiphysiological population model for prediction of the pharmacokinetics of drugs under liver and renal disease conditions.
Drug metabolism and disposition: the biological fate of chemicals 2011;39(7):1278-87.
2011: Oliver W Ackaert; Shanna Shi; Rob Vreeken; Durk Dijkstra; Ben H Westerink; Meindert Danhof; Jeroen De Graan; Oscar Della-Pasqua; Joke A Bouwstra
The pharmacokinetics and pharmacological effect of (S)-5-OH-DPAT following controlled delivery with transdermal iontophoresis.
Journal of pharmaceutical sciences 2011;100(7):2996-3009.
2011: Roosmarijn F W De Cock; Chiara Piana; Elke H J Krekels; Meindert Danhof; Karel Allegaert; Catherijne A J Knibbe
The role of population PK-PD modelling in paediatric clinical research.
European journal of clinical pharmacology 2011;67 Suppl 1():5-16.
2011: G Santen; E van Zwet; P Bettica; R A Gomeni; Meindert Danhof; Oscar Della-Pasqua
From trial and error to trial simulation III: a framework for interim analysis in efficacy trials with antidepressant drugs.
Clinical pharmacology and therapeutics 2011;89(4):602-7.
2011: Elke H J Krekels; J.G. Coen van Hasselt; Dick Tibboel; Meindert Danhof; Catherijne A J Knibbe
Systematic evaluation of the descriptive and predictive performance of paediatric morphine population models.
Pharmaceutical research 2011;28(4):797-811.
2011: Elke H J Krekels; Joost DeJongh; Richard A van Lingen; Caroline D van der Marel; Imti Choonara; Anne M Lynn; Meindert Danhof; Dick Tibboel; Catherijne A J Knibbe
Predictive performance of a recently developed population pharmacokinetic model for morphine and its metabolites in new datasets of (preterm) neonates, infants and children.
Clinical pharmacokinetics 2011;50(1):51-63.
2011: Catherijne A J Knibbe; Elke H J Krekels; Meindert Danhof
Advances in paediatric pharmacokinetics.
Expert opinion on drug metabolism & toxicology 2011;7(1):1-8.
2010: Massimo Cella; Catherijne A J Knibbe; Meindert Danhof; Oscar Della Pasqua
What is the right dose for children?
British journal of clinical pharmacology 2010;70(4):597-603.
2010: Klaus Romero; Brian Corrigan; Christoffer W Tornoe; Jogarao V S Gobburu; Meindert Danhof; William R Gillespie; Marc R Gastonguay; Bernd Meibohm; Hartmut Derendorf
Pharmacometrics as a discipline is entering the "industrialization" phase: standards, automation, knowledge sharing, and training are critical for future success.
Journal of clinical pharmacology 2010;50(9 Suppl):9S-19S.
2010: Gregor Bender; Jeffry A Florian; Stephen Bramwell; Mark J Field; Keith K C Tan; Scott Marshall; Joost DeJongh; Robert R Bies; Meindert Danhof
Pharmacokinetic-pharmacodynamic analysis of the static allodynia response to pregabalin and sildenafil in a rat model of neuropathic pain.
The Journal of pharmacology and experimental therapeutics 2010;334(2):599-608.
2010: O W Ackaert; J De Graan; R Capancioni; Oscar Della-Pasqua; Durk Dijkstra; B H Westerink; Meindert Danhof; Joke A Bouwstra
The in vitro and in vivo evaluation of new synthesized prodrugs of 5-OH-DPAT for iontophoretic delivery.
Journal of controlled release : official journal of the Controlled Release Society 2010;144(3):296-305.
2010: Oliver W Ackaert; Jeroen De Graan; Romano Capancioni; Durk Dijkstra; Meindert Danhof; Joke A Bouwstra
Transdermal iontophoretic delivery of a novel series of dopamine agonists in vitro: physicochemical considerations.
The Journal of pharmacy and pharmacology 2010;62(6):709-20.
2010: Rogier R Press; Bart A Ploeger; Jan den Hartigh; Tahar van der Straaten; Hans van Pelt; Meindert Danhof; Hans de Fijter; Henk-Jan Guchelaar
Explaining variability in ciclosporin exposure in adult kidney transplant recipients.
European journal of clinical pharmacology 2010;66(6):579-90.
2010: Anouk E Muller; Johan W Mouton; Paul M Oostvogel; P Joep Dörr; Rob A Voskuyl; Joost DeJongh; Eric A P Steegers; Meindert Danhof
Pharmacokinetics of clindamycin in pregnant women in the peripartum period.
Antimicrobial agents and chemotherapy 2010;54(5):2175-81.
2010: Tamara J van Steeg; E H J Krekels; Jan Freijer; Meindert Danhof; E C M de Lange
Effect of altered AGP plasma binding on heart rate changes by S(-)-propranolol in rats using mechanism-based estimations of in vivo receptor affinity (K(B,vivo)).
Journal of pharmaceutical sciences 2010;99(5):2511-20.
2010: Jasper Stevens; Dirk-Jan van den Berg; Sanne de Ridder; Harm A G Niederländer; Piet Hein van der Graaf; Meindert Danhof; Elizabeth C M de Lange
Online solid phase extraction with liquid chromatography-tandem mass spectrometry to analyze remoxipride in small plasma-, brain homogenate-, and brain microdialysate samples.
Journal of chromatography. B, Analytical technologies in the biomedical and life sciences 2010;878(13-14):969-75.
2010: Mariska Y M Peeters; Karel Allegaert; Heleen J Blussé van Oud-Alblas; Massimo Cella; Dick Tibboel; Meindert Danhof; Catherijne A J Knibbe
Prediction of propofol clearance in children from an allometric model developed in rats, children and adults versus a 0.75 fixed-exponent allometric model.
Clinical pharmacokinetics 2010;49(4):269-75.
2010: Oscar Della-Pasqua; Gijs W Santen; Meindert Danhof
The missing link between clinical endpoints and drug targets in depression.
Trends in pharmacological sciences 2010;31(4):144-52.
2010: M Cella; F Gorter de Vries; D Burger; Meindert Danhof; Oscar Della-Pasqua
A model-based approach to dose selection in early pediatric development.
Clinical pharmacology and therapeutics 2010;87(3):294-302.
2010: D R H Huntjens; David J M Spalding; Meindert Danhof; Oscar Della-Pasqua
Impact of chronic inflammation on the pharmacokinetic-pharmacodynamic relationship of naproxen.
European journal of pain (London, England) 2010;14(3):227.e1-10.
2010: Teun M Post; Serge C L M Cremers; Thomas Kerbusch; Meindert Danhof
Bone physiology, disease and treatment: towards disease system analysis in osteoporosis.
Clinical pharmacokinetics 2010;49(2):89-118.
2010: Oliver W Ackaert; Jeroen Van Smeden; Jeroen De Graan; Durk Dijkstra; Meindert Danhof; Joke A Bouwstra
Mechanistic studies of the transdermal iontophoretic delivery of 5-OH-DPAT in vitro.
Journal of pharmaceutical sciences 2010;99(1):275-85.
2009: Gregor Bender; James Gosset; Jeff Florian; Keith Tan; Mark Field; Scott Marshall; Joost DeJongh; Robert Bies; Meindert Danhof
Population pharmacokinetic model of the pregabalin-sildenafil interaction in rats: application of simulation to preclinical PK-PD study design.
Pharmaceutical research 2009;26(10):2259-69.
2009: Ralph Clinckers; Ilse Smolders; Katia Vermoesen; Yvette Michotte; Meindert Danhof; Rob Voskuyl; Oscar Della-Pasqua
Prediction of antiepileptic drug efficacy: the use of intracerebral microdialysis to monitor biophase concentrations.
Expert opinion on drug metabolism & toxicology 2009;5(10):1267-77.
2009: Tamara J van Steeg; V B Boralli; E H J Krekels; P Slijkerman; Jan Freijer; Meindert Danhof; E C M de Lange
Influence of plasma protein binding on pharmacodynamics: Estimation of in vivo receptor affinities of beta blockers using a new mechanism-based PK-PD modelling approach.
Journal of pharmaceutical sciences 2009;98(10):3816-28.
2009: G Santen; J Horrigan; Meindert Danhof; Oscar Della-Pasqua
From trial and error to trial simulation. Part 2: an appraisal of current beliefs in the design and analysis of clinical trials for antidepressant drugs.
Clinical pharmacology and therapeutics 2009;86(3):255-62.
2009: G Santen; E van Zwet; Meindert Danhof; Oscar Della-Pasqua
From trial and error to trial simulation. Part 1: the importance of model-based drug development for antidepressant drugs.
Clinical pharmacology and therapeutics 2009;86(3):248-54.
2009: Jasper Stevens; Ernst Suidgeest; Piet H van Der Graaf; Meindert Danhof; Elizabeth C M de Lange
A new minimal-stress freely-moving rat model for preclinical studies on intranasal administration of CNS drugs.
Pharmaceutical research 2009;26(8):1911-7.
2009: Gijs Santen; Meindert Danhof; Oscar Della Pasqua
Sensitivity of the Montgomery Asberg Depression Rating Scale to response and its consequences for the assessment of efficacy.
Journal of psychiatric research 2009;43(12):1049-56.
2009: Hugo J Maas; Meindert Danhof; Oscar Della-Pasqua
Analysis of the relationship between age and treatment response in migraine.
Cephalalgia : an international journal of headache 2009;29(7):772-80.
2009: D R H Huntjens; David J M Spalding; Meindert Danhof; Oscar Della-Pasqua
Differences in the sensitivity of behavioural measures of pain to the selectivity of cyclo-oxygenase inhibitors.
European journal of pain (London, England) 2009;13(5):448-57.
2009: Rogier R Press; Bart A Ploeger; Jan den Hartigh; Tahar van der Straaten; Johannes van Pelt; Meindert Danhof; Johan W de Fijter; Henk-Jan Guchelaar
Explaining variability in tacrolimus pharmacokinetics to optimize early exposure in adult kidney transplant recipients.
Therapeutic drug monitoring 2009;31(2):187-97.
2009: Anouk E Muller; Paul M Oostvogel; Joost DeJongh; Johan W Mouton; Eric A P Steegers; P Joep Dörr; Meindert Danhof; Rob A Voskuyl
Pharmacokinetics of amoxicillin in maternal, umbilical cord, and neonatal sera.
Antimicrobial agents and chemotherapy 2009;53(4):1574-80.
2009: Ibrahim Ince; Saskia N de Wildt; Dick Tibboel; Meindert Danhof; Catherijne A J Knibbe
Tailor-made drug treatment for children: creation of an infrastructure for data-sharing and population PK-PD modeling.
Drug discovery today 2009;14(5-6):316-20.
2009: Catherijne A J Knibbe; Elke H J Krekels; John N van den Anker; Joost DeJongh; Gijs W E Santen; Monique van Dijk; Sinno H P Simons; Richard A van Lingen; Evelyne M Jacqz-Aigrain; Meindert Danhof; Dick Tibboel
Morphine glucuronidation in preterm neonates, infants and children younger than 3 years.
Clinical pharmacokinetics 2009;48(6):371-85.
2009: Bart A Ploeger; Piet H van der Graaf; Meindert Danhof
Incorporating receptor theory in mechanism-based pharmacokinetic-pharmacodynamic (PK-PD) modeling.
Drug metabolism and pharmacokinetics 2009;24(1):3-15.
2009: Bart A Ploeger; Jean Smeets; Ashley Strougo; Henk-Jan Drenth; Ge Ruigt; Natalie Houwing; Meindert Danhof
Pharmacokinetic-pharmacodynamic model for the reversal of neuromuscular blockade by sugammadex.
Anesthesiology 2009;110(1):95-105.
2009: Lia C Liefaard; Bart A Ploeger; Carla F M Molthoff; Hugo W A M de Jong; Jouke Dijkstra; Louise van der Weerd; Adriaan A Lammertsma; Meindert Danhof; Rob A Voskuyl
Changes in GABAA receptor properties in amygdala kindled animals: in vivo studies using [11C]flumazenil and positron emission tomography.
Epilepsia 2009;50(1):88-98.
2008: Anouk E Muller; P Joep Dörr; Johan W Mouton; Joost De Jongh; Paul M Oostvogel; Eric A P Steegers; Rob A Voskuyl; Meindert Danhof
The influence of labour on the pharmacokinetics of intravenously administered amoxicillin in pregnant women.
British journal of clinical pharmacology 2008;66(6):866-74.
2008: Gijs Santen; Meindert Danhof; Oscar Della-Pasqua
Evaluation of treatment response in depression studies using a Bayesian parametric cure rate model.
Journal of psychiatric research 2008;42(14):1189-97.
2008: Gijs Santen; Roberto Gomeni; Meindert Danhof; Oscar Della Pasqua
Sensitivity of the individual items of the Hamilton depression rating scale to response and its consequences for the assessment of efficacy.
Journal of psychiatric research 2008;42(12):1000-9.
2008: H J Maas; N Snelder; Meindert Danhof; O Della Pasqua
Prediction of attack frequency in migraine treatment.
Cephalalgia : an international journal of headache 2008;28(8):847-55.
2008: Dorien Groenendaal; Jan Freijer; Andrea Rosier; Dennis de Mik; Glynis Nicholls; Anne Hersey; Andrew Ayrton; Meindert Danhof; Elizabeth C M de Lange
Pharmacokinetic/pharmacodynamic modelling of the EEG effects of opioids: the role of complex biophase distribution kinetics.
European journal of pharmaceutical sciences : official journal of the European Federation for Pharmaceutical Sciences 2008;34(2-3):149-63.
2008: M Geldof; Jan Freijer; Ludy Van Beijsterveldt; X Langlois; Meindert Danhof
Pharmacokinetic-pharmacodynamic modelling of fluvoxamine 5-HT transporter occupancy in rat frontal cortex.
British journal of pharmacology 2008;154(6):1369-78.
2008: Meindert Danhof; Elizabeth C M de Lange; Oscar Della-Pasqua; Bart A Ploeger; Rob A Voskuyl
Mechanism-based pharmacokinetic-pharmacodynamic (PK-PD) modeling in translational drug research.
Trends in pharmacological sciences 2008;29(4):186-91.
2008: Teun M Post; Jan I Freijer; Bart A Ploeger; Meindert Danhof
Extensions to the visual predictive check to facilitate model performance evaluation.
Journal of pharmacokinetics and pharmacodynamics 2008;35(2):185-202.
2008: Marian Geldof; Jan Freijer; Ludy Van Beijsterveldt; Meindert Danhof
Pharmacokinetic modeling of non-linear brain distribution of fluvoxamine in the rat.
Pharmaceutical research 2008;25(4):792-804.
2008: Marian Geldof; Jan I Freijer; Lambertus A Peletier; Ludy Van Beijsterveldt; Meindert Danhof
Mechanistic model for the acute effect of fluvoxamine on 5-HT and 5-HIAA concentrations in rat frontal cortex.
European journal of pharmaceutical sciences : official journal of the European Federation for Pharmaceutical Sciences 2008;33(3):217-29.
2008: D R H Huntjens; A Strougo; A Chain; A Metcalf; S Summerfield; D J M Spalding; Meindert Danhof; Oscar Della-Pasqua
Population pharmacokinetic modelling of the enterohepatic recirculation of diclofenac and rofecoxib in rats.
British journal of pharmacology 2008;153(5):1072-84.
2008: Tamara J van Steeg; Jan Freijer; Meindert Danhof; Elizabeth C M de Lange
Mechanism-based pharmacodynamic modeling of S(-)-atenolol: estimation of in vivo affinity for the beta1-adrenoceptor with an agonist-antagonist interaction model.
The Journal of pharmacology and experimental therapeutics 2008;324(3):1234-42.
2008: Paulien G M Ravenstijn; Mario Merlini; Marjolijn Hameetman; Tracey K Murray; Mark A Ward; Hywel Lewis; Gareth Ball; Cathy Mottart; Christine de Ville de Goyet; Thomas Xavier Lemarchand; Kristel van Belle; Michael J O'Neill; Meindert Danhof; Elizabeth C M de Lange
The exploration of rotenone as a toxin for inducing Parkinson's disease in rats, for application in BBB transport and PK-PD experiments.
Journal of pharmacological and toxicological methods 2008;57(2):114-30.
2008: Mariska Y M Peeters; L P H J Aarts; Ferenc A Boom; Leo J Bras; Dick Tibboel; Meindert Danhof; Catherijne A J Knibbe
Pilot study on the influence of liver blood flow and cardiac output on the clearance of propofol in critically ill patients.
European journal of clinical pharmacology 2008;64(3):329-34.
2008: Mariska Y M Peeters; L J Bras; Joost DeJongh; Ronald M J Wesselink; L P H J Aarts; Meindert Danhof; Catherijne A J Knibbe
Disease severity is a major determinant for the pharmacodynamics of propofol in critically ill patients.
Clinical pharmacology and therapeutics 2008;83(3):443-51.
2008: Hugo J Maas; Marc A H Spruit; Meindert Danhof; Oscar Della-Pasqua
Relevance of absorption rate and lag time to the onset of action in migraine.
Clinical pharmacokinetics 2008;47(2):139-46.
2008: Anouk E Muller; Joost DeJongh; Paul Oostvogel; Rob A Voskuyl; P Joep Dörr; Meindert Danhof; Johan W Mouton
Amoxicillin pharmacokinetics in pregnant women with preterm premature rupture of the membranes.
American journal of obstetrics and gynecology 2008;198(1):108.e1-6.
2008: Ashraf Yassen; Erik Olofsen; Jingmin Kan; Albert Dahan; Meindert Danhof
Pharmacokinetic-pharmacodynamic modeling of the effectiveness and safety of buprenorphine and fentanyl in rats.
Pharmaceutical research 2008;25(1):183-93.
2007: Marian Geldof; Jan Freijer; Ludy Van Beijsterveldt; Patrick C M Vermote; Anton Megens; Meindert Danhof
Pharmacokinetic-pharmacodynamic modeling of the effect of fluvoxamine on p-chloroamphetamine-induced behavior.
European journal of pharmaceutical sciences : official journal of the European Federation for Pharmaceutical Sciences 2007;32(3):200-8.
2007: Klaas P Zuideveld; Piet H van Der Graaf; Lambertus A Peletier; Meindert Danhof
Allometric scaling of pharmacodynamic responses: application to 5-Ht1A receptor mediated responses from rat to man.
Pharmaceutical research 2007;24(11):2031-9.
2007: Anouk E Muller; Joost DeJongh; Ymka Bult; W H F Goessens; Johan W Mouton; Meindert Danhof; John N van den Anker
Pharmacokinetics of penicillin G in infants with a gestational age of less than 32 weeks.
Antimicrobial agents and chemotherapy 2007;51(10):3720-5.
2007: Vladimir V Anisimov; Hugo J Maas; Meindert Danhof; Oscar Della-Pasqua
Analysis of responses in migraine modelling using hidden Markov models.
Statistics in medicine 2007;26(22):4163-78.
2007: Dorien Groenendaal; Jan Freijer; D de Mik; M R Bouw; Meindert Danhof; Elizabeth C M de Lange
Population pharmacokinetic modelling of non-linear brain distribution of morphine: influence of active saturable influx and P-glycoprotein mediated efflux.
British journal of pharmacology 2007;151(5):701-12.
2007: Dorien Groenendaal; Jan Freijer; D de Mik; M R Bouw; Meindert Danhof; Elizabeth C M de Lange
Influence of biophase distribution and P-glycoprotein interaction on pharmacokinetic-pharmacodynamic modelling of the effects of morphine on the EEG.
British journal of pharmacology 2007;151(5):713-20.
2007: Lia C Liefaard; Rou-Afza F Gunput; Meindert Danhof; Rob A Voskuyl
Decreased Efficacy of GABAA-receptor modulation by midazolam in the kainate model of temporal lobe epilepsy.
Epilepsia 2007;48(7):1378-87.
2007: Tamara J van Steeg; Elke H J Krekels; Meindert Danhof; Elizabeth C M de Lange
Reproducible and time-dependent modification of serum protein binding in Wistar Kyoto rats.
Journal of pharmacological and toxicological methods 2007;56(1):72-8.
2007: Tamara J van Steeg; Jan Freijer; Meindert Danhof; Elizabeth C M de Lange
Pharmacokinetic-pharmacodynamic modelling of S(-)-atenolol in rats: reduction of isoprenaline-induced tachycardia as a continuous pharmacodynamic endpoint.
British journal of pharmacology 2007;151(3):356-66.
2007: Ashraf Yassen; Jingmin Kan; Erik Olofsen; Ernst Suidgeest; Albert Dahan; Meindert Danhof
Pharmacokinetic-pharmacodynamic modeling of the respiratory depressant effect of norbuprenorphine in rats.
The Journal of pharmacology and experimental therapeutics 2007;321(2):598-607.
2007: Daniël M Jonker; Rob A Voskuyl; Meindert Danhof
Synergistic combinations of anticonvulsant agents: what is the evidence from animal experiments?
Epilepsia 2007;48(3):412-34.
2007: Paul Rolan; Meindert Danhof; Donald Stanski; Carl Peck
Current issues relating to drug safety especially with regard to the use of biomarkers: a meeting report and progress update.
European journal of pharmaceutical sciences : official journal of the European Federation for Pharmaceutical Sciences 2007;30(2):107-12.
2007: Ashraf Yassen; Erik Olofsen; Eveline van Dorp; Elise Sarton; Luc Teppema; Meindert Danhof; Albert Dahan
Mechanism-based pharmacokinetic-pharmacodynamic modelling of the reversal of buprenorphine-induced respiratory depression by naloxone : a study in healthy volunteers.
Clinical pharmacokinetics 2007;46(11):965-80.
2007: Ashraf Yassen; Erik Olofsen; Jingmin Kan; Albert Dahan; Meindert Danhof
Animal-to-human extrapolation of the pharmacokinetic and pharmacodynamic properties of buprenorphine.
Clinical pharmacokinetics 2007;46(5):433-47.
2007: Ashraf Yassen; Erik Olofsen; Raymonda Romberg; Elise Sarton; Luc Teppema; Meindert Danhof; Albert Dahan
Mechanism-based PK/PD modeling of the respiratory depressant effect of buprenorphine and fentanyl in healthy volunteers.
Clinical pharmacology and therapeutics 2007;81(1):50-8.
2007: Marian Geldof; Jan Freijer; Ludy Van Beijsterveldt; Philip Timmerman; Abdellah Ahnaou; W H I M Drinkenburg; Meindert Danhof
Population pharmacokinetic model of fluvoxamine in rats: utility for application in animal behavioral studies.
European journal of pharmaceutical sciences : official journal of the European Federation for Pharmaceutical Sciences 2007;30(1):45-55.
2007: Meindert Danhof; Joost de Jongh; Elizabeth C M de Lange; Oscar Della-Pasqua; Bart A Ploeger; Rob A Voskuyl
Mechanism-based pharmacokinetic-pharmacodynamic modeling: biophase distribution, receptor theory, and dynamical systems analysis.
Annual review of pharmacology and toxicology 2007;47():357-400.
2007: Jan I Freijer; Teun M Post; Bart A Ploeger; Joost DeJongh; Meindert Danhof
Application of the convection-dispersion equation to modelling oral drug absorption.
Bulletin of mathematical biology 2007;69(1):181-95.
2006: Mariska Y M Peeters; Sandra A Prins; Catherijne A J Knibbe; Joost DeJongh; Ron A A Mathôt; Celesta Warris; Ron van Schaik; Dick Tibboel; Meindert Danhof
Pharmacokinetics and pharmacodynamics of midazolam and metabolites in nonventilated infants after craniofacial surgery.
Anesthesiology 2006;105(6):1135-46.
2006: Hugo J Maas; Meindert Danhof; Oscar Della-Pasqua
A model-based approach to treatment comparison in acute migraine.
British journal of clinical pharmacology 2006;62(5):591-600.
2006: Ashraf Yassen; Jingmin Kan; Erik Olofsen; Ernst Suidgeest; Albert Dahan; Meindert Danhof
Mechanism-based pharmacokinetic-pharmacodynamic modeling of the respiratory-depressant effect of buprenorphine and fentanyl in rats.
The Journal of pharmacology and experimental therapeutics 2006;319(2):682-92.
2006: Eveline van Dorp; Ashraf Yassen; Elise Sarton; Raymonda Romberg; Erik Olofsen; Luc Teppema; Meindert Danhof; Albert Dahan
Naloxone reversal of buprenorphine-induced respiratory depression.
Anesthesiology 2006;105(1):51-7.
2006: AK Nugroho; Stefan G Romeijn; Raphaël Zwier; Jan B De Vries; Durk Dijkstra; Håkan V Wikström; Oscar Della-Pasqua; Meindert Danhof; Joke A Bouwstra
Pharmacokinetics and pharmacodynamics analysis of transdermal iontophoresis of 5-OH-DPAT in rats: in vitro-in vivo correlation.
Journal of pharmaceutical sciences 2006;95(7):1570-85.
2006: Ashraf Yassen; Erik Olofsen; Raymonda Romberg; Elise Sarton; Meindert Danhof; Albert Dahan
Mechanism-based pharmacokinetic-pharmacodynamic modeling of the antinociceptive effect of buprenorphine in healthy volunteers.
Anesthesiology 2006;104(6):1232-42.
2006: D R H Huntjens; David J M Spalding; Meindert Danhof; Oscar Della-Pasqua
Correlation between in vitro and in vivo concentration-effect relationships of naproxen in rats and healthy volunteers.
British journal of pharmacology 2006;148(4):396-404.
2006: Willem de Winter; Joost DeJongh; Teun M Post; Bart A Ploeger; Richard Urquhart; Ian Moules; David Eckland; Meindert Danhof
A mechanism-based disease progression model for comparison of long-term effects of pioglitazone, metformin and gliclazide on disease processes underlying Type 2 Diabetes Mellitus.
Journal of pharmacokinetics and pharmacodynamics 2006;33(3):313-43.
2006: Albert Dahan; Ashraf Yassen; Raymonda Romberg; Elise Sarton; Luc Teppema; Erik Olofsen; Meindert Danhof
Buprenorphine induces ceiling in respiratory depression but not in analgesia.
British journal of anaesthesia 2006;96(5):627-32.
2006: Hugo J Maas; Meindert Danhof; Oscar Della-Pasqua
Prediction of headache response in migraine treatment.
Cephalalgia : an international journal of headache 2006;26(4):416-22.
2006: Mariska Y M Peeters; Sandra A Prins; Catherijne A J Knibbe; Joost DeJongh; Ron van Schaik; Monique van Dijk; Ilse P van der Heiden; Dick Tibboel; Meindert Danhof
Propofol pharmacokinetics and pharmacodynamics for depth of sedation in nonventilated infants after major craniofacial surgery.
Anesthesiology 2006;104(3):466-74.
2006: Eleonora L Swart; Klaas P Zuideveld; Joost de Jongh; Meindert Danhof; Lambertus G Thijs; Robert M J Strack van Schijndel
Population pharmacodynamic modelling of lorazepam- and midazolam-induced sedation upon long-term continuous infusion in critically ill patients.
European journal of clinical pharmacology 2006;62(3):185-94.
2006: Luigi G Franciosi; Clive P Page; Bartolome R Celli; Mario Cazzola; Michael J Walker; Meindert Danhof; Klaus F Rabe; Oscar Della-Pasqua
Markers of exacerbation severity in chronic obstructive pulmonary disease.
Respiratory research 2006;7():74.
2006: Luigi G Franciosi; Clive P Page; Bartolome R Celli; Mario Cazzola; Michael J Walker; Meindert Danhof; Klaus F Rabe; Oscar Della-Pasqua
Markers of disease severity in chronic obstructive pulmonary disease.
Pulmonary pharmacology & therapeutics 2006;19(3):189-99.
2005: Lia C Liefaard; Bart A Ploeger; Carla F M Molthoff; Ronald Boellaard; Adriaan A Lammertsma; Meindert Danhof; Rob A Voskuyl
Population pharmacokinetic analysis for simultaneous determination of B (max) and K (D) in vivo by positron emission tomography.
Molecular imaging and biology : MIB : the official publication of the Academy of Molecular Imaging 2005;7(6):411-21.
2005: Meindert Danhof; Gunnar Alvan; Svein G Dahl; Jochen Kuhlmann; Gilles Paintaud
Mechanism-based pharmacokinetic-pharmacodynamic modeling-a new classification of biomarkers.
Pharmaceutical research 2005;22(9):1432-7.
2005: Dorien Groenendaal; Margret C M Blom-Roosemalen; Meindert Danhof; Elizabeth C M de Lange
High-performance liquid chromatography of nalbuphine, butorphanol and morphine in blood and brain microdialysate samples: application to pharmacokinetic/pharmacodynamic studies in rats.
Journal of chromatography. B, Analytical technologies in the biomedical and life sciences 2005;822(1-2):230-7.
2005: Gai Ling Li; Tamara J van Steeg; H Putter; J Van Der Spek; Stan Pavel; Meindert Danhof; Joke A Bouwstra
Cutaneous side-effects of transdermal iontophoresis with and without surfactant pretreatment: a single-blinded, randomized controlled trial.
The British journal of dermatology 2005;153(2):404-12.
2005: Teun M Post; Jan I Freijer; Joost DeJongh; Meindert Danhof
Disease system analysis: basic disease progression models in degenerative disease.
Pharmaceutical research 2005;22(7):1038-49.
2005: D R H Huntjens; Meindert Danhof; Oscar Della-Pasqua
Pharmacokinetic-pharmacodynamic correlations and biomarkers in the development of COX-2 inhibitors.
Rheumatology (Oxford, England) 2005;44(7):846-59.
2005: Catherijne A J Knibbe; Klaas P Zuideveld; L P H J Aarts; Paul F M Kuks; Meindert Danhof
Allometric relationships between the pharmacokinetics of propofol in rats, children and adults.
British journal of clinical pharmacology 2005;59(6):705-11.
2005: Corine C Visser; Sanja Stevanović; L Heleen Voorwinden; Louis van Bloois; Pieter J Gaillard; Meindert Danhof; Daan J A Crommelin; Albertus G de Boer
Targeting liposomes with protein drugs to the blood-brain barrier in vitro.
European journal of pharmaceutical sciences : official journal of the European Federation for Pharmaceutical Sciences 2005;25(2-3):299-305.
2005: Albert Dahan; Ashraf Yassen; Hans Bijl; Raymonda Romberg; Elise Sarton; Luc Teppema; Erik Olofsen; Meindert Danhof
Comparison of the respiratory effects of intravenous buprenorphine and fentanyl in humans and rats.
British journal of anaesthesia 2005;94(6):825-34.
2005: Ashraf Yassen; Erik Olofsen; Albert Dahan; Meindert Danhof
Pharmacokinetic-pharmacodynamic modeling of the antinociceptive effect of buprenorphine and fentanyl in rats: role of receptor equilibration kinetics.
The Journal of pharmacology and experimental therapeutics 2005;313(3):1136-49.
2005: Marloes P Schaddelee; Sue D Collins; Joost DeJongh; Albertus G de Boer; Adriaan P IJzerman; Meindert Danhof
Pharmacokinetic/pharmacodynamic modelling of the anti-hyperalgesic and anti-nociceptive effect of adenosine A1 receptor partial agonists in neuropathic pain.
European journal of pharmacology 2005;514(2-3):131-40.
2005: Sandra A Prins; Mariska Y M Peeters; RJ Houmes; Monique van Dijk; Catherijne A J Knibbe; Meindert Danhof; Dick Tibboel
Propofol 6% as sedative in children under 2 years of age following major craniofacial surgery.
British journal of anaesthesia 2005;94(5):630-5.
2005: Daniël M Jonker; Sandra A G Visser; Piet H van Der Graaf; Rob A Voskuyl; Meindert Danhof
Towards a mechanism-based analysis of pharmacodynamic drug-drug interactions in vivo.
Pharmacology & therapeutics 2005;106(1):1-18.
2005: AK Nugroho; Li Li; Durk Dijkstra; Håkan V Wikström; Meindert Danhof; Joke A Bouwstra
Transdermal iontophoresis of the dopamine agonist 5-OH-DPAT in human skin in vitro.
Journal of controlled release : official journal of the Controlled Release Society 2005;103(2):393-403.
2005: AK Nugroho; Oscar Della-Pasqua; Meindert Danhof; Joke A Bouwstra
Compartmental modeling of transdermal iontophoretic transport II: in vivo model derivation and application.
Pharmaceutical research 2005;22(3):335-46.
2005: Eleonora L Swart; Joost de Jongh; Klaas P Zuideveld; Meindert Danhof; Lambertus G Thijs; R J M Strack van Schijndel
Population pharmacokinetics of lorazepam and midazolam and their metabolites in intensive care patients on continuous venovenous hemofiltration.
American journal of kidney diseases : the official journal of the National Kidney Foundation 2005;45(2):360-71.
2005: Gai Ling Li; J J de Vries; Tamara J van Steeg; H van den Bussche; H J Maas; H J E M Reeuwijk; Meindert Danhof; Joke A Bouwstra; Theo van Laar
Transdermal iontophoretic delivery of apomorphine in patients improved by surfactant formulation pretreatment.
Journal of controlled release : official journal of the Controlled Release Society 2005;101(1-3):199-208.
2005: Marloes P Schaddelee; Kevin D Read; Cindy G J Cleypool; Adriaan P IJzerman; Meindert Danhof; Albertus G de Boer
Brain penetration of synthetic adenosine A1 receptor agonists in situ: role of the rENT1 nucleoside transporter and binding to blood constituents.
European journal of pharmaceutical sciences : official journal of the European Federation for Pharmaceutical Sciences 2005;24(1):59-66.
2004: Marloes P Schaddelee; Dorien Groenendaal; Joost DeJongh; C G J Cleypool; Adriaan P IJzerman; Albertus G de Boer; Meindert Danhof
Population pharmacokinetic modeling of blood-brain barrier transport of synthetic adenosine A1 receptor agonists.
The Journal of pharmacology and experimental therapeutics 2004;311(3):1138-46.
2004: Marloes P Schaddelee; Joost DeJongh; Sue D Collins; Albertus G de Boer; Adriaan P IJzerman; Meindert Danhof
Population pharmacokinetic-pharmacodynamic modelling of the anti-hyperalgesic effect of 5'deoxy-N6-cylopentyladenosine in the mononeuropathic rat.
European journal of pharmacology 2004;504(1-2):7-15.
2004: AK Nugroho; Oscar Della Pasqua; Meindert Danhof; Joke A Bouwstra
Compartmental modeling of transdermal iontophoretic transport: I. In vitro model derivation and application.
Pharmaceutical research 2004;21(11):1974-84.
2004: AK Nugroho; Gai Ling Li; Meindert Danhof; Joke A Bouwstra
Transdermal iontophoresis of rotigotine across human stratum corneum in vitro: influence of pH and NaCl concentration.
Pharmaceutical research 2004;21(5):844-50.
2004: Corine C Visser; L Heleen Voorwinden; Daan J A Crommelin; Meindert Danhof; Albertus G de Boer
Characterization and modulation of the transferrin receptor on brain capillary endothelial cells.
Pharmaceutical research 2004;21(5):761-9.
2004: Daniël M Jonker; Rob A Voskuyl; Meindert Danhof
Pharmacodynamic analysis of the anticonvulsant effects of tiagabine and lamotrigine in combination in the rat.
Epilepsia 2004;45(5):424-35.
2004: AK Nugroho; Gailing Li; Arne Grossklaus; Meindert Danhof; Joke A Bouwstra
Transdermal iontophoresis of rotigotine: influence of concentration, temperature and current density in human skin in vitro.
Journal of controlled release : official journal of the Controlled Release Society 2004;96(1):159-67.
2004: Corine C Visser; Sanja Stevanović; L Heleen Voorwinden; Pieter J Gaillard; Daan J A Crommelin; Meindert Danhof; Albertus G de Boer
Validation of the transferrin receptor for drug targeting to brain capillary endothelial cells in vitro.
Journal of drug targeting 2004;12(3):145-50.
2004: Catherijne A J Knibbe; H Naber; L P H J Aarts; Paul F M Kuks; Meindert Danhof
Long-term sedation with propofol 60 mg ml(-1) vs. propofol 10 mg(-1) ml in critically ill, mechanically ventilated patients.
Acta anaesthesiologica Scandinavica 2004;48(3):302-7.
2004: Klaas P Zuideveld; Piet H van Der Graaf; Donald F Newgreen; Richard Thurlow; Nicola Petty; Paul Jordan; Lambertus A Peletier; Meindert Danhof
Mechanism-based pharmacokinetic-pharmacodynamic modeling of 5-HT1A receptor agonists: estimation of in vivo affinity and intrinsic efficacy on body temperature in rats.
The Journal of pharmacology and experimental therapeutics 2004;308(3):1012-20.
2004: Eleonora L Swart; Klaas P Zuideveld; Joost de Jongh; Meindert Danhof; Lambertus G Thijs; Robert M J Strack van Schijndel
Comparative population pharmacokinetics of lorazepam and midazolam during long-term continuous infusion in critically ill patients.
British journal of clinical pharmacology 2004;57(2):135-45.
2004: Corine C Visser; L Heleen Voorwinden; Liesbeth R Harders; Mohamed Eloualid; Louis van Bloois; Daan J A Crommelin; Meindert Danhof; Albertus G de Boer
Coupling of metal containing homing devices to liposomes via a maleimide linker: use of TCEP to stabilize thiol-groups without scavenging metals.
Journal of drug targeting 2004;12(9-10):569-73.
2003: Tjerk J H Bueters; Leonie van Duivenvoorde; Meindert Danhof; Adriaan P IJzerman; Herman P M Van Helden
Cyclopentyladenosine and some of its low-efficacy derivatives inhibit striatal synaptosomal release of acetylcholine to a similar degree.
European journal of pharmacology 2003;481(2-3):141-6.
2003: Gai Ling Li; Arne Grossklaus; Meindert Danhof; Joke A Bouwstra
Iontophoretic R-apomorphine delivery in combination with surfactant pretreatment: in vitro validation studies.
International journal of pharmaceutics 2003;266(1-2):61-8.
2003: Marloes P Schaddelee; Heleen L Voorwinden; Dorien Groenendaal; Anne Hersey; Adriaan P IJzerman; Meindert Danhof; Albertus G de Boer
Blood-brain barrier transport of synthetic adenosine A1 receptor agonists in vitro: structure transport relationships.
European journal of pharmaceutical sciences : official journal of the European Federation for Pharmaceutical Sciences 2003;20(3):347-56.
2003: Sandra A G Visser; D R H Huntjens; Piet H van Der Graaf; Lambertus A Peletier; Meindert Danhof
Mechanism-based modeling of the pharmacodynamic interaction of alphaxalone and midazolam in rats.
The Journal of pharmacology and experimental therapeutics 2003;307(2):765-75.
2003: Daniël M Jonker; C van de Mheen; Paul H C Eilers; MR Kruk; Rob A Voskuyl; Meindert Danhof
Anticonvulsant drugs differentially suppress individual ictal signs: a pharmacokinetic/pharmacodynamic analysis in the cortical stimulation model in the rat.
Behavioral neuroscience 2003;117(5):1076-85.
2003: Tjerk J H Bueters; Adriaan P IJzerman; Herman P M Van Helden; Meindert Danhof
Characterization of the pharmacokinetics, brain distribution, and therapeutic efficacy of the adenosine A1 receptor partial agonist 2'-deoxy-N6-cyclopentyladenosine in sarin-poisoned rats.
Toxicology and applied pharmacology 2003;192(1):86-94.
2003: Tjerk J H Bueters; Herman P M Van Helden; Adriaan P IJzerman; Meindert Danhof
Low efficacy adenosine A1 agonists inhibit striatal acetylcholine release in rats improving central selectivity of action.
Neuroscience letters 2003;343(1):57-61.
2003: Marloes P Schaddelee; Heleen L Voorwinden; Erica W van Tilburg; Tony J Pateman; Adriaan P IJzerman; Meindert Danhof; Albertus G de Boer
Functional role of adenosine receptor subtypes in the regulation of blood-brain barrier permeability: possible implications for the design of synthetic adenosine derivatives.
European journal of pharmaceutical sciences : official journal of the European Federation for Pharmaceutical Sciences 2003;19(1):13-22.
2003: Gai Ling Li; Meindert Danhof; Peter M Frederik; Joke A Bouwstra
Pretreatment with a water-based surfactant formulation affects transdermal iontophoretic delivery of R-apomorphine in vitro.
Pharmaceutical research 2003;20(4):653-9.
2003: Daniël M Jonker; Dick A C Vermeij; Peter M Edelbroek; Rob A Voskuyl; Vladimir K Piotrovsky; Meindert Danhof
Pharmacodynamic analysis of the interaction between tiagabine and midazolam with an allosteric model that incorporates signal transduction.
Epilepsia 2003;44(3):329-38.
2003: Tjerk J H Bueters; Marloes J A Joosen; Herman P M Van Helden; Adriaan P IJzerman; Meindert Danhof
Adenosine A1 receptor agonist N6-cyclopentyladenosine affects the inactivation of acetylcholinesterase in blood and brain by sarin.
The Journal of pharmacology and experimental therapeutics 2003;304(3):1307-13.
2003: Sandra A G Visser; F L C Wolters; Piet H van Der Graaf; Lambertus A Peletier; Meindert Danhof
Dose-dependent EEG effects of zolpidem provide evidence for GABA(A) receptor subtype selectivity in vivo.
The Journal of pharmacology and experimental therapeutics 2003;304(3):1251-7.
2003: Sandra A G Visser; F L C Wolters; Josy M Gubbens-Stibbe; EJ Tukker; Piet H van Der Graaf; Lambertus A Peletier; Meindert Danhof
Mechanism-based pharmacokinetic/pharmacodynamic modeling of the electroencephalogram effects of GABAA receptor modulators: in vitro-in vivo correlations.
The Journal of pharmacology and experimental therapeutics 2003;304(1):88-101.
2002: Catherijne A J Knibbe; Klaas P Zuideveld; Joost DeJongh; Paul F M Kuks; L P H J Aarts; Meindert Danhof
Population pharmacokinetic and pharmacodynamic modeling of propofol for long-term sedation in critically ill patients: a comparison between propofol 6% and propofol 1%.
Clinical pharmacology and therapeutics 2002;72(6):670-84.
2002: Klaas P Zuideveld; Jasna Rusiç-Pavletiç; Hugo J Maas; Lambertus A Peletier; Piet H van Der Graaf; Meindert Danhof
Pharmacokinetic-pharmacodynamic modeling of buspirone and its metabolite 1-(2-pyrimidinyl)-piperazine in rats.
The Journal of pharmacology and experimental therapeutics 2002;303(3):1130-7.
2002: Tjerk J H Bueters; Herman P M Van Helden; Meindert Danhof; Adriaan P IJzerman
Effects of the adenosine A1 receptor allosteric modulators PD 81,723 and LUF 5484 on the striatal acetylcholine release.
European journal of pharmacology 2002;454(2-3):177-82.
2002: Gai Ling Li; Ronald van der Geest; Laurence Chanet; Elske van Zanten; Meindert Danhof; Joke A Bouwstra
In vitro iontophoresis of R-apomorphine across human stratum corneum. Structure-transport relationship of penetration enhancement.
Journal of controlled release : official journal of the Controlled Release Society 2002;84(1-2):49-57.
2002: Tjerk J H Bueters; Bas Groen; Meindert Danhof; Adriaan P IJzerman; Herman P M Van Helden
Therapeutic efficacy of the adenosine A1 receptor agonist N6-cyclopentyladenosine (CPA) against organophosphate intoxication.
Archives of toxicology 2002;76(11):650-6.
2002: Sandra A G Visser; W W F T Gladdines; Piet H van Der Graaf; Lambertus A Peletier; Meindert Danhof
Neuroactive steroids differ in potency but not in intrinsic efficacy at the GABA(A) receptor in vivo.
The Journal of pharmacology and experimental therapeutics 2002;303(2):616-26.
2002: Catherijne A J Knibbe; Gitte Melenhorst-de Jong; Maaike Mestrom; Carin M A Rademaker; Allart F A Reijnvaan; Klaas P Zuideveld; Paul F M Kuks; Hans van Vught; Meindert Danhof
Pharmacokinetics and effects of propofol 6% for short-term sedation in paediatric patients following cardiac surgery.
British journal of clinical pharmacology 2002;54(4):415-22.
2002: Sandra A G Visser; C J G M Smulders; B P R Reijers; Piet H van Der Graaf; Lambertus A Peletier; Meindert Danhof
Mechanism-based pharmacokinetic-pharmacodynamic modeling of concentration-dependent hysteresis and biphasic electroencephalogram effects of alphaxalone in rats.
The Journal of pharmacology and experimental therapeutics 2002;302(3):1158-67.
2002: Klaas P Zuideveld; Aukje van Gestel; Lambertus A Peletier; Piet H van Der Graaf; Meindert Danhof
Pharmacokinetic-pharmacodynamic modelling of the hypothermic and corticosterone effects of the 5-HT1A receptor agonist flesinoxan.
European journal of pharmacology 2002;445(1-2):43-54.
2002: Bert Tuk; Toon van Gool; Meindert Danhof
Mechanism-based pharmacodynamic modeling of the interaction of midazolam, bretazenil, and zolpidem with ethanol.
Journal of pharmacokinetics and pharmacodynamics 2002;29(3):235-50.
2002: Eleonora L Swart; Ben van der Hoven; A B Johan Groeneveld; Daan J Touw; Meindert Danhof
Correlation between midazolam and lignocaine pharmacokinetics and MEGX formation in healthy volunteers.
British journal of clinical pharmacology 2002;53(2):133-9.
2002: Meindert Danhof; S A G Visser
Pharmaco-electroencephalography and pharmacokinetic-pharmacodynamic modeling in drug development: focus on preclinical steps.
Methods and findings in experimental and clinical pharmacology 2002;24 Suppl D():127-8.
2002: Meindert Danhof
Electroencephalography parameters as biomarkers: extrapolation from laboratory animals to humans.
Methods and findings in experimental and clinical pharmacology 2002;24 Suppl D():63-4.
2002: Elizabeth C M de Lange; Meindert Danhof
Considerations in the use of cerebrospinal fluid pharmacokinetics to predict brain target concentrations in the clinical setting: implications of the barriers between blood and brain.
Clinical pharmacokinetics 2002;41(10):691-703.
2002: Klaas P Zuideveld; Nicoline Treijtel; Hugo J Maas; Josy M Gubbens-Stibbe; Lambertus A Peletier; Piet H van Der Graaf; Meindert Danhof
A competitive interaction model predicts the effect of WAY-100,635 on the time course of R-(+)-8-hydroxy-2-(di-n-propylamino)tetralin-induced hypothermia.
The Journal of pharmacology and experimental therapeutics 2002;300(1):330-8.
2001: Klaas P Zuideveld; Hugo J Maas; Nicoline Treijtel; J Hulshof; Piet H van Der Graaf; Lambertus A Peletier; Meindert Danhof
A set-point model with oscillatory behavior predicts the time course of 8-OH-DPAT-induced hypothermia.
American journal of physiology. Regulatory, integrative and comparative physiology 2001;281(6):R2059-71.
2001: Gai Ling Li; Meindert Danhof; Joke A Bouwstra
Effect of elastic liquid-state vesicle on apomorphine iontophoresis transport through human skin in vitro.
Pharmaceutical research 2001;18(11):1627-30.
2001: Gai Ling Li; Meindert Danhof; Joke A Bouwstra
Lontophoretic delivery of apomorphine in vitro: physicochemic considerations.
Pharmaceutical research 2001;18(11):1509-13.
2000: Anne-Marie Cleton; B A Altorf; Rob A Voskuyl; Meindert Danhof
Pharmacokinetic-pharmacodynamic modelling of tiagabine CNS effects upon chronic treatment in rats: lack of change in concentration-EEG effect relationship.
European journal of pharmaceutical sciences : official journal of the European Federation for Pharmaceutical Sciences 2000;12(2):141-50.
2000: Sandra A G Visser; C J Smulders; W W Gladdines; Hubertus Irth; Piet H van Der Graaf; Meindert Danhof
High-performance liquid chromatography of the neuroactive steroids alphaxalone and pregnanolone in plasma using dansyl hydrazine as fluorescent label: application to a pharmacokinetic-pharmacodynamic study in rats.
Journal of chromatography. B, Biomedical sciences and applications 2000;745(2):357-63.
2000: Mats O Karlsson; Rik C Schoemaker; B Kemp; Adam Cohen; J M A van Gerven; B Tuk; C C Peck; Meindert Danhof
A pharmacodynamic Markov mixed-effects model for the effect of temazepam on sleep.
Clinical pharmacology and therapeutics 2000;68(2):175-88.
2000: Anne-Marie Cleton; B A Altorf; Rob A Voskuyl; Meindert Danhof
Effect of amygdala kindling on the central nervous system effects of tiagabine: EEG effects versus brain GABA levels.
British journal of pharmacology 2000;130(5):1037-44.
2000: M Garrido; Josy M Gubbens-Stibbe; EJ Tukker; E Cox; J von Frijtag; D Künzel; Adriaan P IJzerman; Meindert Danhof; Piet H van Der Graaf
Pharmacokinetic-pharmacodynamic analysis of the EEG effect of alfentanil in rats following beta-funaltrexamine-induced mu-opioid receptor "knockdown" in vivo.
Pharmaceutical research 2000;17(6):653-9.
2000: OE Della Paschoa; A Hoogerkamp; Peter M Edelbroek; Rob A Voskuyl; Meindert Danhof
Pharmacokinetic-pharmacodynamic correlation of lamotrigine, flunarizine, loreclezole, CGP40116 and CGP39551 in the cortical stimulation model.
Epilepsy research 2000;40(1):41-52.
2000: Catherijne A J Knibbe; L P H J Aarts; Paul F M Kuks; H J Voortman; L Lie-A-Huen; L J Bras; Meindert Danhof
Pharmacokinetics and pharmacodynamics of propofol 6% SAZN versus propofol 1% SAZN and Diprivan-10 for short-term sedation following coronary artery bypass surgery.
European journal of clinical pharmacology 2000;56(1):89-95.
2000: Anne-Marie Cleton; J Odman; Piet H van Der Graaf; W Ghijsen; Rob A Voskuyl; Meindert Danhof
Mechanism-based modeling of functional adaptation upon chronic treatment with midazolam.
Pharmaceutical research 2000;17(3):321-7.
2000: Klaas P Zuideveld; Nicoline Treijtel; Piet H van Der Graaf; Meindert Danhof
Enantioselective high-performance liquid chromatographic analysis of the 5-HT1A receptor agonist 8-hydroxy-2-(di-n-propylamino)tetralin. Application to a pharmacokinetic-pharmacodynamic study in rats.
Journal of chromatography. B, Biomedical sciences and applications 2000;738(1):67-73.
1999: Anne-Marie Cleton; HJ de Greef; Peter M Edelbroek; Rob A Voskuyl; Meindert Danhof
Stereoselective central nervous system effects of the R- and S-isomers of the GABA uptake blocker N-(4, 4-di-(3-methylthien-2-yl)but-3-enyl) nipecotic acid in the rat.
British journal of pharmacology 1999;128(8):1651-8.
1999: Anne-Marie Cleton; Piet H van Der Graaf; W Ghijsen; Rob A Voskuyl; Meindert Danhof
Mechanism-based modeling of adaptive changes in the pharmacodynamics of midazolam in the kindling model of epilepsy.
Pharmaceutical research 1999;16(11):1702-9.
1999: Catherijne A J Knibbe; VS Koster; L P H J Aarts; HJ Langemeijer; Meindert Danhof
Pilot study in humans on the pharmacokinetics and safety of propofol 6% SAZN.
Pharmacy world & science : PWS 1999;21(5):239-40.
1999: Piet H van Der Graaf; EA van Schaick; Sandra A G Visser; HJ de Greef; Adriaan P IJzerman; Meindert Danhof
Mechanism-based pharmacokinetic-pharmacodynamic modeling of antilipolytic effects of adenosine A(1) receptor agonists in rats: prediction of tissue-dependent efficacy in vivo.
The Journal of pharmacology and experimental therapeutics 1999;290(2):702-9.
1999: Anne-Marie Cleton; HJ de Greef; Peter M Edelbroek; Rob A Voskuyl; Meindert Danhof
Application of a combined "effect compartment/indirect response model" to the central nervous system effects of tiagabine in the rat.
Journal of pharmacokinetics and biopharmaceutics 1999;27(3):301-23.
1999: Catherijne A J Knibbe; H J Voortman; L P H J Aarts; Paul F M Kuks; R Lange; HJ Langemeijer; Meindert Danhof
Pharmacokinetics, induction of anaesthesia and safety characteristics of propofol 6% SAZN vs propofol 1% SAZN and Diprivan-10 after bolus injection.
British journal of clinical pharmacology 1999;47(6):653-60.
1999: Anne-Marie Cleton; D Mazee; Rob A Voskuyl; Meindert Danhof
Rate of change of blood concentrations is a major determinant of the pharmacodynamics of midazolam in rats.
British journal of pharmacology 1999;127(1):227-35.
1999: Bert Tuk; M F van Oostenbruggen; V M Herben; JW Mandema; Meindert Danhof
Characterization of the pharmacodynamic interaction between parent drug and active metabolite in vivo: midazolam and alpha-OH-midazolam.
The Journal of pharmacology and experimental therapeutics 1999;289(2):1067-74.
1999: Piet H van Der Graaf; J Nilsson; EA van Schaick; Meindert Danhof
Multivariate quantitative structure-pharmacokinetic relationships (QSPKR) analysis of adenosine A1 receptor agonists in rat.
Journal of pharmaceutical sciences 1999;88(3):306-12.
1999: EH Cox; MW Langemeijer; Josy M Gubbens-Stibbe; K T Muir; Meindert Danhof
The comparative pharmacodynamics of remifentanil and its metabolite, GR90291, in a rat electroencephalographic model.
Anesthesiology 1999;90(2):535-44.
1999: Theo van Laar; Ronald van der Geest; Meindert Danhof
Future delivery systems for apomorphine in patients with Parkinson's disease.
Advances in neurology 1999;80():535-44.
1998: OE Della Paschoa; MR Kruk; Rob A Voskuyl; Meindert Danhof
Effects of repeated seizure induction on seizure activity, post-ictal and interictal behavior.
Brain research 1998;814(1-2):199-208.
1998: OE Della Paschoa; Rob A Voskuyl; Meindert Danhof
Modelling of the pharmacodynamic interaction between phenytoin and sodium valproate.
British journal of pharmacology 1998;125(7):1610-6.
1998: OE Della Paschoa; MR Kruk; R Hamstra; Rob A Voskuyl; Meindert Danhof
Pharmacodynamic interaction between phenytoin and sodium valproate changes seizure thresholds and pattern.
British journal of pharmacology 1998;125(5):997-1004.
1998: Anne-Marie Cleton; Rob A Voskuyl; Meindert Danhof
Adaptive changes in the pharmacodynamics of midazolam in different experimental models of epilepsy: kindling, cortical stimulation and genetic absence epilepsy.
British journal of pharmacology 1998;125(4):615-20.
1998: EA van Schaick; Klaas P Zuideveld; H E Tukker; MW Langemeijer; Adriaan P IJzerman; Meindert Danhof
Metabolic and cardiovascular effects of the adenosine A1 receptor agonist N6-(p-sulfophenyl)adenosine in diabetic Zucker rats: influence of the disease on the selectivity of action.
The Journal of pharmacology and experimental therapeutics 1998;287(1):21-30.
1998: EH Cox; JA Kuipers; Meindert Danhof
Pharmacokinetic-pharmacodynamic modelling of the EEG effect of alfentanil in rats: assessment of rapid functional adaptation.
British journal of pharmacology 1998;124(7):1534-40.
1998: EA van Schaick; H E Tukker; H C Roelen; Adriaan P IJzerman; Meindert Danhof
Selectivity of action of 8-alkylamino analogues of N6-cyclopentyladenosine in vivo: haemodynamic versus anti-lipolytic responses in rats.
British journal of pharmacology 1998;124(3):607-18.
1998: Ronald van der Geest; Theo van Laar; P P Kruger; Josy M Gubbens-Stibbe; Harry E Boddé; Raymund A C Roos; Meindert Danhof
Pharmacokinetics, enantiomer interconversion, and metabolism of R-apomorphine in patients with idiopathic Parkinson's disease.
Clinical neuropharmacology 1998;21(3):159-68.
1998: Theo van Laar; Ronald van der Geest; Meindert Danhof; Harry E Boddé; P H Goossens; Raymund A C Roos
Stepwise intravenous infusion of apomorphine to determine the therapeutic window in patients with Parkinson's disease.
Clinical neuropharmacology 1998;21(3):152-8.
1998: EH Cox; Catherijne A J Knibbe; VS Koster; MW Langemeijer; E E Tukker; R Lange; Paul F M Kuks; HJ Langemeijer; L Lie-A-Huen; Meindert Danhof
Influence of different fat emulsion-based intravenous formulations on the pharmacokinetics and pharmacodynamics of propofol.
Pharmaceutical research 1998;15(3):442-8.
1998: EH Cox; T Kerbusch; Piet H van Der Graaf; Meindert Danhof
Pharmacokinetic-pharmacodynamic modeling of the electroencephalogram effect of synthetic opioids in the rat: correlation with the interaction at the mu-opioid receptor.
The Journal of pharmacology and experimental therapeutics 1998;284(3):1095-103.
1998: EH Cox; MW Langemeijer; Meindert Danhof
Pharmacokinetic-pharmacodynamic modelling of the analgesic effect of alfentanil in the rat using tooth pulp evoked potentials.
Journal of pharmacological and toxicological methods 1998;39(1):19-27.
1998: OE Della Paschoa; JW Mandema; Rob A Voskuyl; Meindert Danhof
Pharmacokinetic-pharmacodynamic modeling of the anticonvulsant and electroencephalogram effects of phenytoin in rats.
The Journal of pharmacology and experimental therapeutics 1998;284(2):460-6.
1998: Ronald van der Geest; Meindert Danhof; Harry E Boddé
Validation and testing of a new iontophoretic continuous flow through transport cell.
Journal of controlled release : official journal of the Controlled Release Society 1998;51(1):85-91.
1998: OE Della Paschoa; MR Kruk; Meindert Danhof
Phamacokinetic-pharmacodynamic modelling of behavioural responses.
Neuroscience and biobehavioral reviews 1998;23(2):229-36.
1998: Bert Tuk; V M Herben; JW Mandema; Meindert Danhof
Relevance of arteriovenous concentration differences in pharmacokinetic-pharmacodynamic modeling of midazolam.
The Journal of pharmacology and experimental therapeutics 1998;284(1):202-7.
1997: EA van Schaick; HJ de Greef; Adriaan P IJzerman; Meindert Danhof
Physiological indirect effect modeling of the antilipolytic effects of adenosine A1-receptor agonists.
Journal of pharmacokinetics and biopharmaceutics 1997;25(6):673-94.
1997: EA van Schaick; C Kulkarni; Jacobien K Von Frijtag Drabbe Künzel; R A Mathôt; G Cristalli; Adriaan P IJzerman; Meindert Danhof
Time course of action of three adenosine A1 receptor agonists with differing lipophilicity in rats: comparison of pharmacokinetic, haemodynamic and EEG effects.
Naunyn-Schmiedeberg's archives of pharmacology 1997;356(6):827-37.
1997: Ronald van der Geest; Theo van Laar; Josy M Gubbens-Stibbe; Harry E Boddé; Meindert Danhof
Iontophoretic delivery of apomorphine. II: An in vivo study in patients with Parkinson's disease.
Pharmaceutical research 1997;14(12):1804-10.
1997: Ronald van der Geest; Meindert Danhof; Harry E Boddé
Iontophoretic delivery of apomorphine. I: In vitro optimization and validation.
Pharmaceutical research 1997;14(12):1798-803.
1997: Ronald van der Geest; P Kruger; Josy M Gubbens-Stibbe; Theo van Laar; H E Bodde; Meindert Danhof
Assay of R-apomorphine, S-apomorphine, apocodeine, isoapocodeine and their glucuronide and sulfate conjugates in plasma and urine of patients with Parkinson's disease.
Journal of chromatography. B, Biomedical sciences and applications 1997;702(1-2):131-41.
1997: Piet H van Der Graaf; EA van Schaick; R A Math-ot; Adriaan P IJzerman; Meindert Danhof
Mechanism-based pharmacokinetic-pharmacodynamic modeling of the effects of N6-cyclopentyladenosine analogs on heart rate in rat: estimation of in vivo operational affinity and efficacy at adenosine A1 receptors.
The Journal of pharmacology and experimental therapeutics 1997;283(2):809-16.
1997: EA van Schaick; R A Math-ot; Josy M Gubbens-Stibbe; MW Langemeijer; H C Roelen; Adriaan P IJzerman; Meindert Danhof
8-Alkylamino-substituted analogs of N6-cyclopentyladenosine are partial agonists for the cardiovascular adenosine A1 receptors in vivo.
The Journal of pharmacology and experimental therapeutics 1997;283(2):800-8.
1997: OE Della Paschoa; MR Kruk; R Hamstra; Rob A Voskuyl; Meindert Danhof
Seizure patterns in kindling and cortical stimulation models of experimental epilepsy.
Brain research 1997;770(1-2):221-7.
1997: EH Cox; J G Van Hemert; EJ Tukker; Meindert Danhof
Pharmacokinetic-pharmacodynamic modelling of the EEG effect of alfentanil in rats.
Journal of pharmacological and toxicological methods 1997;38(2):99-108.
1997: B Tuk; JJ Oberyé; Monique S M Pieters; Rik C Schoemaker; B Kemp; J M A van Gerven; Meindert Danhof; HA Kamphuisen; Adam Cohen; Douwe D Breimer; C C Peck
Pharmacodynamics of temazepam in primary insomnia: assessment of the value of quantitative electroencephalography and saccadic eye movements in predicting improvement of sleep.
Clinical pharmacology and therapeutics 1997;62(4):444-52.
1997: Piet H van Der Graaf; Meindert Danhof
Analysis of drug-receptor interactions in vivo: a new approach in pharmacokinetic-pharmacodynamic modelling.
International journal of clinical pharmacology and therapeutics 1997;35(10):442-6.
1997: EA van Schaick; HJ de Greef; MW Langemeijer; M J Sheehan; Adriaan P IJzerman; Meindert Danhof
Pharmacokinetic-pharmacodynamic modelling of the anti-lipolytic and anti-ketotic effects of the adenosine A1-receptor agonist N6-(p-sulphophenyl)adenosine in rats.
British journal of pharmacology 1997;122(3):525-33.
1997: Elizabeth C M de Lange; Meindert Danhof; Albertus G de Boer; Douwe D Breimer
Methodological considerations of intracerebral microdialysis in pharmacokinetic studies on drug transport across the blood-brain barrier.
Brain research. Brain research reviews 1997;25(1):27-49.
1997: A L van Steveninck; A E Wallnöfer; Rik C Schoemaker; Monique S M Pieters; Meindert Danhof; J M A van Gerven; Adam Cohen
A study of the effects of long-term use on individual sensitivity to temazepam and lorazepam in a clinical population.
British journal of clinical pharmacology 1997;44(3):267-75.
1997: Douwe D Breimer; Meindert Danhof
Relevance of the application of pharmacokinetic-pharmacodynamic modelling concepts in drug development. The "wooden shoe' paradigm.
Clinical pharmacokinetics 1997;32(4):259-67.
1997: Bert Tuk; Meindert Danhof; JW Mandema
The impact of arteriovenous concentration differences on pharmacodynamic parameter estimates.
Journal of pharmacokinetics and biopharmaceutics 1997;25(1):39-62.
1996: R A Mathot; E M Wenden; Willem Soudijn; Douwe D Breimer; Adriaan P IJzerman; Meindert Danhof
Partial agonism of the nonselective adenosine receptor agonist 8-butylaminoadenosine at the A1 receptor in vivo.
The Journal of pharmacology and experimental therapeutics 1996;279(3):1439-46.
1996: A Hoogerkamp; R H Arends; A M Bomers; JW Mandema; Rob A Voskuyl; Meindert Danhof
Pharmacokinetic/pharmacodynamic relationship of benzodiazepines in the direct cortical stimulation model of anticonvulsant effect.
The Journal of pharmacology and experimental therapeutics 1996;279(2):803-12.
1996: EA van Schaick; Kenneth Alan Jacobson; H O Kim; Adriaan P IJzerman; Meindert Danhof
Hemodynamic effects and histamine release elicited by the selective adenosine A3 receptor agonist 2-Cl-IB-MECA in conscious rats.
European journal of pharmacology 1996;308(3):311-4.
1996: R A Mathoôt; Willem Soudijn; Douwe D Breimer; Adriaan P IJzerman; Meindert Danhof
Pharmacokinetic-haemodynamic relationships of 2-chloroadenosine at adenosine A1 and A2a receptors in vivo.
British journal of pharmacology 1996;118(2):369-77.
1996: Meindert Danhof
Applications of pharmacokinetic/pharmacodynamic research in rational drug development.
Methods and findings in experimental and clinical pharmacology 1996;18 Suppl C():53-4.
1995: E C de Lange; Meindert Danhof; C Zurcher; Albertus G de Boer; Douwe D Breimer
Repeated microdialysis perfusions: periprobe tissue reactions and BBB permeability.
Brain research 1995;702(1-2):261-5.
1995: E C de Lange; J D de Vries; C Zurcher; Meindert Danhof; Albertus G de Boer; Douwe D Breimer
The use of intracerebral microdialysis for the determination of pharmacokinetic profiles of anticancer drugs in tumor-bearing rat brain.
Pharmaceutical research 1995;12(12):1924-31.
1995: E C de Lange; M R Bouw; JW Mandema; Meindert Danhof; Albertus G de Boer; Douwe D Breimer
Application of intracerebral microdialysis to study regional distribution kinetics of drugs in rat brain.
British journal of pharmacology 1995;116(5):2538-44.
1995: R A Mathôt; E M Van der Wenden; Willem Soudijn; Adriaan P IJzerman; Meindert Danhof
Deoxyribose analogues of N6-cyclopentyladenosine (CPA): partial agonists at the adenosine A1 receptor in vivo.
British journal of pharmacology 1995;116(3):1957-64.
1995: R A Mathôt; Josy M Gubbens-Stibbe; Willem Soudijn; Kenneth Alan Jacobson; Adriaan P IJzerman; Meindert Danhof
Quantification of the in vivo potency of the adenosine A2 receptor antagonist 8-(3-chlorostyryl)caffeine.
The Journal of pharmacology and experimental therapeutics 1995;275(1):245-53.
1995: E M van der Wenden; Jacobien K Von Frijtag Drabbe Künzel; R A Mathôt; Meindert Danhof; Adriaan P IJzerman; Willem Soudijn
Ribose-modified adenosine analogues as potential partial agonists for the adenosine receptor.
Journal of medicinal chemistry 1995;38(20):4000-6.
1995: E M Van der Wenden; H R Hartog-Witte; H C Roelen; Jacobien K Von Frijtag Drabbe Künzel; I M Pirovano; R A Mathôt; Meindert Danhof; Arthur Van Aerschot; M J Lidaks; Adriaan P IJzerman
8-substituted adenosine and theophylline-7-riboside analogues as potential partial agonists for the adenosine A1 receptor.
European journal of pharmacology 1995;290(3):189-99.
1995: S Appel; R A Mathôt; MW Langemeijer; Adriaan P IJzerman; Meindert Danhof
Modelling of the pharmacodynamic interaction of an A1 adenosine receptor agonist and antagonist in vivo: N6-cyclopentyladenosine and 8-cyclopentyltheophylline.
British journal of pharmacology 1995;115(7):1253-9.
1995: R A Mathôt; B C Van den Aarsen; Willem Soudijn; Douwe D Breimer; Adriaan P IJzerman; Meindert Danhof
Pharmacokinetic-pharmacodynamic modelling of the cardiovascular effects of R- and S-N6-phenylisopropyladenosine in conscious normotensive rats.
The Journal of pharmacology and experimental therapeutics 1995;273(1):405-14.
1995: R A Mathôt; Anne-Marie Cleton; Willem Soudijn; Adriaan P IJzerman; Meindert Danhof
Pharmacokinetic modelling of the haemodynamic effects of the A2a adenosine receptor agonist CGS 21680C in conscious normotensive rats.
British journal of pharmacology 1995;114(4):761-8.
1995: C Hoyo-Vadillo; JW Mandema; Meindert Danhof
Pharmacodynamic interaction between midazolam and a low dose of ethanol in vivo.
Life sciences 1995;57(4):325-33.
1994: E C de Lange; Meindert Danhof; Albertus G de Boer; Douwe D Breimer
Critical factors of intracerebral microdialysis as a technique to determine the pharmacokinetics of drugs in rat brain.
Brain research 1994;666(1):1-8.
1994: Adriaan P IJzerman; E M van der Wenden; Jacobien K Von Frijtag Drabbe Künzel; R A Mathôt; Meindert Danhof; P A Borea; K Varani
Partial agonism of theophylline-7-riboside on adenosine receptors.
Naunyn-Schmiedeberg's archives of pharmacology 1994;350(6):638-45.
1994: Hubertus Irth; Anne-Marie Cleton; R A Mathôt; Meindert Danhof; Adriaan P IJzerman; Ubbo R Tjaden; Jan van der Greef
Liquid chromatographic determination of the adenosine receptor agonist CGS 21680 in blood using on-line solid-phase extraction on a phenylboronic acid support and fluorescence detection.
Journal of chromatography. B, Biomedical applications 1994;658(1):207-12.
1994: R A Mathôt; B C Van den Aarsen; J K von Frijtag Drabble Künzel; Meindert Danhof; Adriaan P IJzerman
Assessment of the enantiomeric purity of R- and S-N6-phenylisopropyladenosine (PIA): implications for adenosine receptor subclassification.
Naunyn-Schmiedeberg's archives of pharmacology 1994;350(1):109-12.
1994: A Hoogerkamp; P W Vis; Meindert Danhof; Rob A Voskuyl
Characterization of the pharmacodynamics of several antiepileptic drugs in a direct cortical stimulation model of anticonvulsant effect in the rat.
The Journal of pharmacology and experimental therapeutics 1994;269(2):521-8.
1994: R A Mathôt; EA van Schaick; MW Langemeijer; Willem Soudijn; Douwe D Breimer; Adriaan P IJzerman; Meindert Danhof
Pharmacokinetic-pharmacodynamic relationship of the cardiovascular effects of adenosine A1 receptor agonist N6-cyclopentyladenosine in the rat.
The Journal of pharmacology and experimental therapeutics 1994;268(2):616-24.
1993: R A Mathôt; S Appel; EA van Schaick; Willem Soudijn; Adriaan P IJzerman; Meindert Danhof
High-performance liquid chromatography of the adenosine A1 agonist N6-cyclopentyladenosine and the A1 antagonist 8-cyclopentyltheophylline and its application in a pharmacokinetic study in rats.
Journal of chromatography 1993;620(1):113-20.
1993: A L Van Steveninck; JW Mandema; B Tuk; J G Van Dijk; H C Schoemaker; Meindert Danhof; Adam Cohen
A comparison of the concentration-effect relationships of midazolam for EEG-derived parameters and saccadic peak velocity.
British journal of clinical pharmacology 1993;36(2):109-15.
1993: A M Stijnen; S Hovinga; MW Langemeijer; A Hoogerkamp; C F van Bezooijen; Meindert Danhof
Increased sensitivity to the anticonvulsant effect of valproate in aging BN/BiRij rats.
Pharmaceutical research 1993;10(7):1046-51.
1993: J B Van Bree; Albertus G de Boer; Meindert Danhof; Douwe D Breimer
Drug transport across the blood-brain barrier. III. Mechanisms and methods to improve drug delivery to the central nervous system.
Pharmacy world & science : PWS 1993;15(1):2-9.
1993: Meindert Danhof; JW Mandema; A Hoogerkamp; R A Mathôt
Pharmacokinetic-pharmacodynamic modelling in pre-clinical investigations: principles and perspectives.
European journal of drug metabolism and pharmacokinetics 1993;18(1):41-7.
1992: J B Van Bree; Albertus G de Boer; Meindert Danhof; Douwe D Breimer
Drug transport across the blood-brain barrier. II. Experimental techniques to study drug transport.
Pharmaceutisch weekblad. Scientific edition 1992;14(6):338-48.
1992: Meindert Danhof; JW Mandema
Modelling of the pharmacodynamics and pharmacodynamic interactions of CNS active drugs.
International journal of clinical pharmacology, therapy, and toxicology 1992;30(11):516-9.
1992: A M Stijnen; Meindert Danhof; C F van Bezooijen
Age and the pharmacokinetic-pharmacodynamic relationship of phenobarbital in rats: "pseudo"-longitudinal vs cross-sectional study design.
Pharmaceutical research 1992;9(11):1456-9.
1992: A M Stijnen; C E Heeremans; C F Van Bezooijen; W M Niessen; Meindert Danhof
Disposition of heptabarbitone in the rat: identification of a new metabolite by tandem mass spectrometry.
The Journal of pharmacy and pharmacology 1992;44(11):907-10.
1992: J B Van Bree; Albertus G de Boer; Meindert Danhof; Douwe D Breimer
Drug transport across the blood--brain barrier. I. Anatomical and physiological aspects.
Pharmaceutisch weekblad. Scientific edition 1992;14(5):305-10.
1992: JW Mandema; Meindert Danhof
Electroencephalogram effect measures and relationships between pharmacokinetics and pharmacodynamics of centrally acting drugs.
Clinical pharmacokinetics 1992;23(3):191-215.
1992: S Hovinga; A M Stijnen; MW Langemeijer; JW Mandema; C F van Bezooijen; Meindert Danhof
Pharmacokinetic-EEG effect relationship of midazolam in aging BN/BiRij rats.
British journal of pharmacology 1992;107(1):171-7.
1992: A M Stijnen; I Postel-Westra; MW Langemeijer; A Hoogerkamp; Rob A Voskuyl; C F van Bezooijen; Meindert Danhof
Pharmacodynamics of the anticonvulsant effect of oxazepam in aging BN/BiRij rats.
British journal of pharmacology 1992;107(1):165-70.
1992: Rob A Voskuyl; A Hoogerkamp; Meindert Danhof
Properties of the convulsive threshold determined by direct cortical stimulation in rats.
Epilepsy research 1992;12(2):111-20.
1992: JW Mandema; B Tuk; A L van Steveninck; Douwe D Breimer; Adam Cohen; Meindert Danhof
Pharmacokinetic-pharmacodynamic modeling of the central nervous system effects of midazolam and its main metabolite alpha-hydroxymidazolam in healthy volunteers.
Clinical pharmacology and therapeutics 1992;51(6):715-28.
1992: JW Mandema; C D Heijligers-Feijen; E Tukker; Albertus G de Boer; Meindert Danhof
Modeling of the effect site equilibration kinetics and pharmacodynamics of racemic baclofen and its enantiomers using quantitative EEG effect measures.
The Journal of pharmacology and experimental therapeutics 1992;261(1):88-95.
1992: A M Stijnen; Meindert Danhof; C F Van Bezooijen
Increased sensitivity to the anesthetic effect of phenobarbital in aging BN/BiRij rats.
The Journal of pharmacology and experimental therapeutics 1992;261(1):81-7.
1992: JW Mandema; M T Kuck; Meindert Danhof
In vivo modeling of the pharmacodynamic interaction between benzodiazepines which differ in intrinsic efficacy.
The Journal of pharmacology and experimental therapeutics 1992;261(1):56-61.
1992: P A Soons; G van den Berg; Meindert Danhof; P van Brummelen; J B M J Jansen; Cornelis B H W Lamers; Douwe D Breimer
Influence of single- and multiple-dose omeprazole treatment on nifedipine pharmacokinetics and effects in healthy subjects.
European journal of clinical pharmacology 1992;42(3):319-24.
1992: Meindert Danhof; A de Boer; H N Magnani; J C Stiekema
Pharmacokinetic considerations on Orgaran (Org 10172) therapy.
Haemostasis 1992;22(2):73-84.
1992: JW Mandema; M T Kuck; Meindert Danhof
Differences in intrinsic efficacy of benzodiazepines are reflected in their concentration-EEG effect relationship.
British journal of pharmacology 1992;105(1):164-70.
1992: JW Mandema; E Tukker; Meindert Danhof
In vivo characterization of the pharmacodynamic interaction of a benzodiazepine agonist and antagonist: midazolam and flumazenil.
The Journal of pharmacology and experimental therapeutics 1992;260(1):36-44.
1991: JW Mandema; P Veng-Pedersen; Meindert Danhof
Estimation of amobarbital plasma-effect site equilibration kinetics. Relevance of polyexponential conductance functions.
Journal of pharmacokinetics and biopharmaceutics 1991;19(6):617-34.
1991: A de Boer; J C Stiekema; Meindert Danhof; Theo van Dinther; J K Boeijinga; Adam Cohen; Douwe D Breimer
Studies of interaction of a low-molecular-weight heparinoid (Org 10172) with cloxacillin and ticarcillin in healthy male volunteers.
Antimicrobial agents and chemotherapy 1991;35(10):2110-5.
1991: C E Heeremans; A M Stijnen; R A van der Hoeven; W M Niessen; Meindert Danhof; Jan van der Greef
Liquid chromatography-thermospray tandem mass spectrometry for identification of a heptabarbital metabolite and sample work-up artefacts.
Journal of chromatography 1991;554(1-2):205-14.
1991: A de Boer; Meindert Danhof; Adam Cohen; H N Magnani; Douwe D Breimer
Interaction study between Org 10172, a low molecular weight heparinoid, and acetylsalicylic acid in healthy male volunteers.
Thrombosis and haemostasis 1991;66(2):202-7.
1991: A de Boer; J C Stiekema; Meindert Danhof; Douwe D Breimer
Influence of chlorthalidone on the pharmacokinetics and pharmacodynamics of Org 10172 (Lomoparan), a low molecular weight heparinoid, in healthy volunteers.
Journal of clinical pharmacology 1991;31(7):611-7.
1991: A De Boer; J C Stiekema; Meindert Danhof; Douwe D Breimer
The influence of Org 10172, a low molecular weight heparinoid, on antipyrine metabolism and the effect of enzyme induction on the response to Org 10172.
British journal of clinical pharmacology 1991;32(1):23-9.
1991: Lars Breimer; Anton G L Burm; Meindert Danhof; P J Hennis; Arie A Vletter; J W de Voogt; J Spierdijk; James Bovill
Pharmacokinetic-pharmacodynamic modelling of the interaction between flumazenil and midazolam in volunteers by aperiodic EEG analysis.
Clinical pharmacokinetics 1991;20(6):497-508.
1991: L T Breimer; P J Hennis; Anton G L Burm; Meindert Danhof; James Bovill; J Spierdijk; Arie A Vletter
Pharmacokinetics and EEG effects of flumazenil in volunteers.
Clinical pharmacokinetics 1991;20(6):491-6.
1991: JW Mandema; L N Sansom; M C Dios-Vièitez; M Hollander-Jansen; Meindert Danhof
Pharmacokinetic-pharmacodynamic modeling of the electroencephalographic effects of benzodiazepines. Correlation with receptor binding and anticonvulsant activity.
The Journal of pharmacology and experimental therapeutics 1991;257(1):472-8.
1991: JW Mandema; E Tukker; Meindert Danhof
Pharmacokinetic-pharmacodynamic modelling of the EEG effects of midazolam in individual rats: influence of rate and route of administration.
British journal of pharmacology 1991;102(3):663-8.
1991: J B van Bree; C D Heijligers-Feijen; Albertus G de Boer; Meindert Danhof; Douwe D Breimer
Stereoselective transport of baclofen across the blood-brain barrier in rats as determined by the unit impulse response methodology.
Pharmaceutical research 1991;8(2):259-62.
1991: JW Mandema; Josy M Gubbens-Stibbe; Meindert Danhof
Stability and pharmacokinetics of flumazenil in the rat.
Psychopharmacology 1991;103(3):384-7.
1991: A de Boer; J C Stiekema; Meindert Danhof; A J Moolenaar; Douwe D Breimer
Interaction of ORG 10172, a low molecular weight heparinoid, and digoxin in healthy volunteers.
European journal of clinical pharmacology 1991;41(3):245-50.
1990: JW Mandema; Meindert Danhof
Pharmacokinetic-pharmacodynamic modeling of the central nervous system effects of heptabarbital using aperiodic EEG analysis.
Journal of pharmacokinetics and biopharmaceutics 1990;18(5):459-81.
1990: J B van Bree; S Tio; Albertus G de Boer; Meindert Danhof; Jan Verhoef; Douwe D Breimer
Transport of desglycinamide-arginine vasopressin across the blood-brain barrier in rats as evaluated by the unit impulse response methodology.
Pharmaceutical research 1990;7(3):293-8.
1990: J Dingemanse; B M Hameter; Meindert Danhof
Pharmacodynamics of tolerance development to the anesthetic and anticonvulsant effects of phenobarbital in rats.
Journal of pharmaceutical sciences 1990;79(3):207-11.
1990: L T Breimer; P J Hennis; Anton G L Burm; Meindert Danhof; James Bovill; J Spierdijk; Arie A Vletter
Quantification of the EEG effect of midazolam by aperiodic analysis in volunteers. Pharmacokinetic/pharmacodynamic modelling.
Clinical pharmacokinetics 1990;18(3):245-53.
1990: J Dingemanse; Rob A Voskuyl; MW Langemeijer; I Postel-Westra; Douwe D Breimer; H Meinardi; Meindert Danhof
Pharmacokinetic-pharmacodynamic modelling of the anticonvulsant effect of oxazepam in individual rats.
British journal of pharmacology 1990;99(1):53-8.
1990: J C Stiekema; A de Boer; Meindert Danhof; C Kroon; A W Broekmans; Theo van Dinther; J Voerman; Douwe D Breimer
Interaction of the combined medication with the new low-molecular-weight heparinoid Lomoparan (Org 10172) and acenocoumarol.
Haemostasis 1990;20(3):136-46.
1989: J van Harten; P van Brummelen; P Ooms; Meindert Danhof; Gerard J Blauw; Douwe D Breimer
Variability in the pharmacokinetics of nisoldipine as caused by differences in liver blood flow response.
Journal of clinical pharmacology 1989;29(8):714-21.
1989: J B van Bree; A V Baljet; A van Geyt; Albertus G de Boer; Meindert Danhof; Douwe D Breimer
The unit impulse response procedure for the pharmacokinetic evaluation of drug entry into the central nervous system.
Journal of pharmacokinetics and biopharmaceutics 1989;17(4):441-62.
1989: M Hollander-Jansen; J Dingemanse; MW Langemeijer; Meindert Danhof
Relationship between receptor occupancy at 37 degrees C and the anticonvulsant effect of flunitrazepam in rats.
Pharmaceutical research 1989;6(7):585-91.
1989: J B van Bree; Albertus G de Boer; Jan Verhoef; Meindert Danhof; Douwe D Breimer
Transport of vasopressin fragments across the blood-brain barrier: in vitro studies using monolayer cultures of bovine brain endothelial cells.
The Journal of pharmacology and experimental therapeutics 1989;249(3):901-5.
1989: J van Harten; Jacobus Burggraaf; Meindert Danhof; P van Brummelen; Douwe D Breimer
The contribution of nisoldipine-induced changes in liver blood flow to its pharmacokinetics after oral administration.
British journal of clinical pharmacology 1989;27(5):581-6.
1989: J Dingemanse; J B van Bree; Meindert Danhof
Pharmacokinetic modeling of the anticonvulsant action of phenobarbital in rats.
The Journal of pharmacology and experimental therapeutics 1989;249(2):601-8.
1989: J van Harten; P van Brummelen; Meindert Danhof; R P Quekel; Douwe D Breimer
Pharmacokinetics and hemodynamic effects of long-term nisoldipine treatment in hypertensive patients.
Journal of cardiovascular pharmacology 1989;13(4):624-9.
1989: Rob A Voskuyl; J Dingemanse; Meindert Danhof
Determination of the threshold for convulsions by direct cortical stimulation.
Epilepsy research 1989;3(2):120-9.
1988: J B van Bree; Albertus G de Boer; Meindert Danhof; L A Ginsel; Douwe D Breimer
Characterization of an "in vitro" blood-brain barrier: effects of molecular size and lipophilicity on cerebrovascular endothelial transport rates of drugs.
The Journal of pharmacology and experimental therapeutics 1988;247(3):1233-9.
1988: J H Schellens; J H van der Wart; Meindert Danhof; E A van der Velde; Douwe D Breimer
Relationship between the metabolism of antipyrine, hexobarbitone and theophylline in man as assessed by a 'cocktail' approach.
British journal of clinical pharmacology 1988;26(4):373-84.
1988: J Dingemanse; D Thomassen; B H Mentink; Meindert Danhof
Strategy to assess the role of (inter)active metabolites in pharmacodynamic studies in-vivo: a model study with heptabarbital.
The Journal of pharmacy and pharmacology 1988;40(8):552-7.
1988: J Dingemanse; M Polhuijs; Meindert Danhof
Altered pharmacokinetic-pharmacodynamic relationship of heptabarbital in experimental renal failure in rats.
The Journal of pharmacology and experimental therapeutics 1988;246(1):371-6.
1988: J van Harten; P van Brummelen; R R Zeegers; Meindert Danhof; Douwe D Breimer
The influence of infusion rate on the pharmacokinetics and haemodynamic effects of nisoldipine in man.
British journal of clinical pharmacology 1988;25(6):709-17.
1988: J B van Bree; Albertus G de Boer; Meindert Danhof; Jan Verhoef; T B van Wimersma Greidanus; Douwe D Breimer
Radioimmunoassay of desglycinamide-arginine vasopressin and its application in a pharmacokinetic study in the rat.
Peptides 1988;9(3):555-9.
1988: J Dingemanse; P H Hutson; MW Langemeijer; G Curzon; Meindert Danhof
Application of serial sampling of cerebrospinal fluid in pharmacodynamic studies with a drug active in the CNS: heptabarbital concentrations at onset and offset of loss of righting reflex in rats.
Neuropharmacology 1988;27(5):467-74.
1988: J Dingemanse; F A Sollie; Douwe D Breimer; Meindert Danhof
Pharmacokinetic modeling of the anticonvulsant response of oxazepam in rats using the pentylenetetrazol threshold concentration as pharmacodynamic measure.
Journal of pharmacokinetics and biopharmaceutics 1988;16(2):203-28.
1988: J van Harten; P van Brummelen; M T Lodewijks; Meindert Danhof; Douwe D Breimer
Pharmacokinetics and hemodynamic effects of nisoldipine and its interaction with cimetidine.
Clinical pharmacology and therapeutics 1988;43(3):332-41.
1988: J Dingemanse; Meindert Danhof; Douwe D Breimer
Pharmacokinetic-pharmacodynamic modeling of CNS drug effects: an overview.
Pharmacology & therapeutics 1988;38(1):1-52.
1987: J van Harten; K Burggraaf; Meindert Danhof; P van Brummelen; Douwe D Breimer
Negligible sublingual absorption of nifedipine.
Lancet 1987;2(8572):1363-5.