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Gerd Dannhardt

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Christopher Ganser; Thomas Kindler; Jan-Peter Kramb; Eva Lauermann; Annett Maderer; Markus Moehler; Stanislav Plutizki; Torsten Stauder; Gerd Dannhardt
Novel 3-Azaindolyl-4-arylmaleimides exhibiting potent antiangiogenic efficacy, protein kinase inhibition, and antiproliferative activity.
Finn K Hansen; Mehdi Khankischpur; Renata Mesaros; Ibrahim Tolaymat; Gerd Dannhardt; Detlef Geffken
Efficient synthesis and 5-LOX/COX-inhibitory activity of some 3-hydroxybenzo[b]thiophene-2-carboxylic acid derivatives.
Florian H Heidel; Jan-Peter Kramb; Daniel B Lipka; Thomas S Mack; Stanislav Plutizki; Elena Razumovskaya; Lars Rönnstrand; Anne Ballaschk; Marie-Christine Blum; Gerd Dannhardt; Thomas Fischer
3,4-Diarylmaleimides-a novel class of kinase inhibitors-effectively induce apoptosis in FLT3-ITD-dependent cells.

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2012: Christopher Ganser; Thomas Kindler; Jan-Peter Kramb; Eva Lauermann; Annett Maderer; Markus Moehler; Stanislav Plutizki; Torsten Stauder; Gerd Dannhardt
Novel 3-Azaindolyl-4-arylmaleimides exhibiting potent antiangiogenic efficacy, protein kinase inhibition, and antiproliferative activity.
Journal of medicinal chemistry 2012;55(22):9531-40.
2012: Finn K Hansen; Mehdi Khankischpur; Renata Mesaros; Ibrahim Tolaymat; Gerd Dannhardt; Detlef Geffken
Efficient synthesis and 5-LOX/COX-inhibitory activity of some 3-hydroxybenzo[b]thiophene-2-carboxylic acid derivatives.
Bioorganic & medicinal chemistry letters 2012;22(15):5031-4.
2012: Florian H Heidel; Jan-Peter Kramb; Daniel B Lipka; Thomas S Mack; Stanislav Plutizki; Elena Razumovskaya; Lars Rönnstrand; Anne Ballaschk; Marie-Christine Blum; Gerd Dannhardt; Thomas Fischer
3,4-Diarylmaleimides-a novel class of kinase inhibitors-effectively induce apoptosis in FLT3-ITD-dependent cells.
Annals of hematology 2012;91(3):331-44.
2009: Kriengsak Lirdprapamongkol; Jan-Peter Kramb; Tuangporn Suthiphongchai; Rudee Surarit; Chantragan Srisomsap; Gerd Dannhardt; Jisnuson Svasti
Vanillin suppresses metastatic potential of human cancer cells through PI3K inhibition and decreases angiogenesis in vivo.
Journal of agricultural and food chemistry 2009;57(8):3055-63.
2009: Michael Scholz; Holger Ulbrich; Oliver Soehnlein; Lennart Lindbom; Andreas Mattern; Gerd Dannhardt
Diaryl-dithiolanes and -isothiazoles: COX-1/COX-2 and 5-LOX-inhibitory, *OH scavenging and anti-adhesive activities.
Bioorganic & medicinal chemistry 2009;17(2):558-68.
2008: Michaela Jansen; Holger Rabe; Axelle Strehle; Sandra Dieler; Fabian Debus; Gerd Dannhardt; Myles H Akabas; Hartmut Lüddens
Synthesis of GABAA receptor agonists and evaluation of their alpha-subunit selectivity and orientation in the GABA binding site.
Journal of medicinal chemistry 2008;51(15):4430-48.
2008: Michael Scholz; Holger Ulbrich; Gerd Dannhardt
Investigations concerning the COX/5-LOX inhibiting and hydroxyl radical scavenging potencies of novel 4,5-diaryl isoselenazoles.
European journal of medicinal chemistry 2008;43(6):1152-9.
2008: Kriengsak Lirdprapamongkol; Jan-Peter Kramb; Daranee Chokchaichamnankit; Chantragan Srisomsap; Rudee Surarit; Monnipha Sila-asna; Ahnond Bunyaratvej; Gerd Dannhardt; Jisnuson Svasti
Juice of eclipta prostrata inhibits cell migration in vitro and exhibits anti-angiogenic activity in vivo.
In vivo (Athens, Greece) 2008;22(3):363-8.
2008: Michael Scholz; Holger Ulbrich; Andreas Mattern; Jan-Peter Kramb; Werner Kiefer; Gerd Dannhardt
Investigations concerning the correlation of COX-1 inhibitory and hydroxyl radical scavenging activity.
Archiv der Pharmazie 2008;341(5):281-7.
2007: Gerd Dannhardt; Werner Kiefer
[New antiepileptics in development].
Pharmazie in unserer Zeit 2007;36(4):306-10.
2007: Gerd Dannhardt; Werner Kiefer
[Antiepileptics--action principles and structural parameters].
Pharmazie in unserer Zeit 2007;36(4):270-81.
2006: Christian Peifer; Agata Krasowski; Nina Hämmerle; Oliver Kohlbacher; Gerd Dannhardt; Frank Totzke; Christoph Schächtele; Stefan Laufer
Profile and molecular modeling of 3-(indole-3-yl)-4-(3,4,5-trimethoxyphenyl)-1 H-pyrrole-2,5-dione (1) as a highly selective VEGF-R2/3 inhibitor.
Journal of medicinal chemistry 2006;49(25):7549-53.
2006: Holger Ulbrich; Andreas Luxenburger; Philip Prech; Einar E Eriksson; Oliver Soehnlein; Pierre Rotzius; Lennart Lindbom; Gerd Dannhardt
A novel class of potent nonglycosidic and nonpeptidic pan-selectin inhibitors.
Journal of medicinal chemistry 2006;49(20):5988-99.
2006: Christian Peifer; Thomas Stoiber; Eberhard Unger; Frank Totzke; Christoph Schächtele; Dieter Marmé; Ruth Brenk; Gerhard Klebe; Dieter Schollmeyer; Gerd Dannhardt
Design, synthesis, and biological evaluation of 3,4-diarylmaleimides as angiogenesis inhibitors.
Journal of medicinal chemistry 2006;49(4):1271-81.
2005: Werner Kiefer; Gerd Dannhardt
COX-2 inhibition and pain management: a review summary.
Expert review of clinical immunology 2005;1(3):431-42.
2005: Holger Ulbrich; Oliver Soehnlein; X Xie; Einar E Eriksson; Lennart Lindbom; Wolfgang Albrecht; Stefan Laufer; Gerd Dannhardt
Licofelone, a novel 5-LOX/COX-inhibitor, attenuates leukocyte rolling and adhesion on endothelium under flow.
Biochemical pharmacology 2005;70(1):30-6.
2005: Holger Ulbrich; Philip Prech; Andreas Luxenburger; Gerd Dannhardt
Characterization of a computerized assay for rapid and easy determination of leukocyte adhesion to endothelial cells.
Biological & pharmaceutical bulletin 2005;28(4):718-24.
2005: Frank Rösch; Gerhard Gründer; Mathias Schreckenberger; Gerd Dannhardt
[Radiopharmaceutical strategies and clinical applications. Diagnosis of CNS disease with PET as well as SPECT].
Pharmazie in unserer Zeit 2005;34(6):474-82.
2004: Werner Kiefer; Gerd Dannhardt
Novel insights and therapeutical applications in the field of inhibitors of COX-2.
Current medicinal chemistry 2004;11(24):3147-61.
2004: Christian Peifer; Gerd Dannhardt
A novel quantitative chick embryo assay as an angiogenesis model using digital image analysis.
Anticancer research 2004;24(3a):1545-51.
2003: Michaela Jansen; Gerd Dannhardt
Variations of acidic functions at position 2 and substituents at positions 4, 5 and 6 of the indole moiety and their effect on NMDA-glycine site affinity.
European journal of medicinal chemistry 2003;38(10):855-65.
2003: Martin G Banwell; Anna Bezos; Satish Chand; Gerd Dannhardt; Werner Kiefer; Ulrike Nowe; Christopher R Parish; G Paul Savage; Holger Ulbrich
Convergent synthesis and preliminary biological evaluations of the stilbenolignan (+/-)-aiphanol and various congeners.
Organic & biomolecular chemistry 2003;1(14):2427-9.
2003: Michaela Jansen; Gerd Dannhardt
Antagonists and agonists at the glycine site of the NMDA receptor for therapeutic interventions.
European journal of medicinal chemistry 2003;38(7-8):661-70.
2003: Thomas M Böhme; Christine Keim; Kai Kreutzmann; Matthias Linder; Theo Dingermann; Gerd Dannhardt; Ernst Mutschler; Günter Lambrecht
Structure-activity relationships of dimethindene derivatives as new M2-selective muscarinic receptor antagonists.
Journal of medicinal chemistry 2003;46(5):856-67.
2003: Michaela Jansen; Heidrun Potschka; Claudia Brandt; Wolfgang Löscher; Gerd Dannhardt
Hydantoin-substituted 4,6-dichloroindole-2-carboxylic acids as ligands with high affinity for the glycine binding site of the NMDA receptor.
Journal of medicinal chemistry 2003;46(1):64-73.
2002: Holger Ulbrich; Bernd L Fiebich; Gerd Dannhardt
Cyclooxygenase-1/2 (COX-1/COX-2) and 5-lipoxygenase (5-LOX) inhibitors of the 6,7-diaryl-2,3-1H-dihydropyrrolizine type.
European journal of medicinal chemistry 2002;37(12):953-9.
2002: Henning Danz; Stefka Stoyanova; Olivier Thomet; Hans-Uwe Simon; Gerd Dannhardt; Holger Ulbrich; Matthias Hamburger
Inhibitory activity of tryptanthrin on prostaglandin and leukotriene synthesis.
Planta medica 2002;68(10):875-80.
2002: Werner Kiefer; Gerd Dannhardt
COX-2 inhibition and the control of pain.
Current opinion in investigational drugs (London, England : 2000) 2002;3(9):1348-58.
2002: Anke Friese; Katja Hell-Momeni; Ilse Zündorf; Thomas Winckler; Theo Dingermann; Gerd Dannhardt
Synthesis and biological evaluation of cycloalkylidene carboxylic acids as novel effectors of Ras/Raf interaction.
Journal of medicinal chemistry 2002;45(7):1535-42.
2002: Gerd Dannhardt; Bernd L Fiebich; Johannes Schweppenhäuser
COX-1/COX-2 inhibitors based on the methanone moiety.
European journal of medicinal chemistry 2002;37(2):147-61.
2002: Holger Ulbrich; Gerd Dannhardt
[A heterogenous drug class. NSAID: classification and spectrum of action].
Pharmazie in unserer Zeit 2002;31(2):146-54.
2001: BK Kohl; Gerd Dannhardt
The NMDA receptor complex: a promising target for novel antiepileptic strategies.
Current medicinal chemistry 2001;8(11):1275-89.
2001: Harald Weigmann; Sebastian Härtter; S Maehrlein; Werner Kiefer; G Krämer; Gerd Dannhardt; Christoph Hiemke
Simultaneous determination of olanzapine, clozapine and demethylated metabolites in serum by on-line column-switching high-performance liquid chromatography.
Journal of chromatography. B, Biomedical sciences and applications 2001;759(1):63-71.
2001: Gerd Dannhardt; Werner Kiefer
1-Pyrrolines (3,4-dihydro-2H-pyrroles) as a template for new drugs.
Archiv der Pharmazie 2001;334(6):183-8.
2001: T M Böhme; C Keim; Gerd Dannhardt; Ernst Mutschler; Günter Lambrecht
Design and pharmacology of quinuclidine derivatives as M2-selective muscarinic receptor ligands.
Bioorganic & medicinal chemistry letters 2001;11(9):1241-3.
2001: Gerd Dannhardt; Holger Ulbrich
In-vitro test system for the evaluation of cyclooxygenase-1 (COX-1) and cyclooxygenase-2 (COX-2) inhibitors based on a single HPLC run with UV detection using bovine aortic coronary endothelial cells (BAECs).
Inflammation research : official journal of the European Histamine Research Society ... [et al.] 2001;50(5):262-9.
2001: Gerd Dannhardt; Werner Kiefer
Cyclooxygenase inhibitors--current status and future prospects.
European journal of medicinal chemistry 2001;36(2):109-26.
2000: Gerd Dannhardt; S Laufer
Structural approaches to explain the selectivity of COX-2 inhibitors: is there a common pharmacophore?
Current medicinal chemistry 2000;7(11):1101-12.
2000: Gerd Dannhardt; M von Gruchalla; BK Kohl; C G Parsons
A novel series of 2-carboxytetrahydroquinolines provides new insights into the eastern region of glycine site NMDA antagonists.
Archiv der Pharmazie 2000;333(8):267-74.
2000: A M Sobottka; W Werner; G Blaschke; Werner Kiefer; Ulrike Nowe; Gerd Dannhardt; Elfrides E S Schapoval; Eloir P Schenkel; G K Scriba
Effect of flavonol derivatives on the carrageenin-induced paw edema in the rat and inhibition of cyclooxygenase-1 and 5-lipoxygenase in vitro.
Archiv der Pharmazie 2000;333(7):205-10.
2000: Gerd Dannhardt; Werner Kiefer; G Krämer; S Maehrlein; Ulrike Nowe; Bernd L Fiebich
The pyrrole moiety as a template for COX-1/COX-2 inhibitors.
European journal of medicinal chemistry 2000;35(5):499-510.
2000: Gerd Dannhardt; BK Kohl
Benzimidazoles as NMDA glycine-site antagonists: study on the structural requirements in 2-position of the ligand.
Archiv der Pharmazie 2000;333(5):123-9.
2000: Vincenzo Tumiatti; J Wehrle; Caren Hildebrandt; U Moser; Gerd Dannhardt; Ernst Mutschler; Günter Lambrecht
Muscarinic properties of compounds related to arecaidine propargyl ester.
Arzneimittel-Forschung 2000;50(1):11-5.
1998: Gerd Dannhardt; L Flemmer; R W Hartmann; A Kleber; E Schulze
Spectrofluorimetric quantification of malondialdehyde for evaluation of cyclooxygenase-1/thromboxane synthase inhibition.
Archiv der Pharmazie 1998;331(11):359-64.
1998: Gerd Dannhardt; BK Kohl
The glycine site on the NMDA receptor: structure-activity relationships and possible therapeutic applications.
Current medicinal chemistry 1998;5(4):253-63.
1997: Stefan Laufer; H G Striegel; K Neher; P Zechmeister; C Donat; K Stolingwa; S Baur; Susanne Tries; T Kammermeier; Gerd Dannhardt; Werner Kiefer
Synthesis and evaluation of a novel series of pyrrolizine derivatives as dual cyclooxygenase-1 and 5-lipoxygenase inhibitors.
Archiv der Pharmazie 1997;330(9-10):307-12.
1997: Gerd Dannhardt; M Kreher; Ulrike Nowe; S Schmitt
[2-Aryl-pyrrolo[2,1-b]benzothiazoles as a selective or dual inhibitors of cyclo-oxygenases and 5-lipoxygenases. 21. Non-steroidal anti-inflammatory agents].
Die Pharmazie 1997;52(6):428-36.
1997: Gerd Dannhardt; A Bauer; Ulrike Nowe
Non-steroidal anti-inflammatory agents, Part 24. Pyrrolidino enaminones as models to mimic arachidonic acid.
Archiv der Pharmazie 1997;330(3):74-82.
1996: Gerd Dannhardt; A Bauer
Pyrrolidino enaminones structural related to gyrase inhibitors: synthesis, cyclization and pharmacological activity.
Die Pharmazie 1996;51(11):805-10.
1996: Gerd Dannhardt; M Kreher; Ulrike Nowe; A Pies
Non-steroidal anti-inflammatory agents, Part 20. Method for testing non-steroidal anti-inflammatories: the modified hen's egg chorioallantoic membrane test (HET-CAM test) compared to other procedures.
Archiv der Pharmazie 1996;329(6):301-10.
1995: Gerd Dannhardt; W Kiefer; Ulrike Nowe
Non-steroidal anti-inflammatory agents, Part 19. E-2-pyrrolizin-5-yl acrylic acids as potent dual or selective inhibitors of bovine cyclooxygenase and 5-lipoxygenase.
Archiv der Pharmazie 1995;328(9):681-6.
1995: Gerd Dannhardt; G Lambrecht; Stefan Laufer; E Mutschler; J Schweiger
Regioisomeric 5(3)-aminomethyl-3(5)-phenylisoxazoles: synthesis, spectroscopic discrimination, and muscarinic activity.
Archiv der Pharmazie 1995;328(5):437-43.
1994: Gerd Dannhardt; J Schweiger; G Lambrecht; E Mutschler
Synthesis and muscarinic activity of isoxazole-substituted 1,2,5,6-tetrahydropyridines.
Archiv der Pharmazie 1994;327(11):751-2.
1994: Gerd Dannhardt; W Kiefer
Nonsteroidal antiinflammatory agents, XVIII: C-5 functionalized 6,7-diphenyl-2,3-dihydro-1H-pyrrolizines as inhibitors of bovine cyclooxygenase and 5-lipoxygenase.
Archiv der Pharmazie 1994;327(8):509-14.
1994: Stefan Laufer; J Augustin; Gerd Dannhardt; W Kiefer
(6,7-Diaryldihydropyrrolizin-5-yl)acetic acids, a novel class of potent dual inhibitors of both cyclooxygenase and 5-lipoxygenase.
Journal of medicinal chemistry 1994;37(12):1894-7.
1994: Stefan Laufer; Susanne Tries; J Augustin; Gerd Dannhardt
Pharmacological profile of a new pyrrolizine derivative inhibiting the enzymes cyclo-oxygenase and 5-lipoxygenase.
Arzneimittel-Forschung 1994;44(5):629-36.
1993: Gerd Dannhardt; P Dominiak; Stefan Laufer
Hypertensive effects and structure-activity relationships of 5-omega-aminoalkyl isoxazoles.
Arzneimittel-Forschung 1993;43(4):441-4.
1993: Gerd Dannhardt; M Lehr
Nonsteroidal antiinflammatory agents, XVII: Inhibition of bovine cyclooxygenase and 5-lipoxygenase by N-alkyldiphenyl-pyrrolyl acetic and propionic acid derivatives.
Archiv der Pharmazie 1993;326(3):157-62.
1992: Gerd Dannhardt; M Lehr
In-vitro evaluation of 5-lipoxygenase and cyclo-oxygenase inhibitors using bovine neutrophils and platelets and HPLC.
The Journal of pharmacy and pharmacology 1992;44(5):419-24.
1991: Gerd Dannhardt; P Dominiak; Stefan Laufer
[Hypertensive action of 5-(beta-aminoethyl)aminoisoxazoles: synthesis and screening of isoxazolopyrazines and isoxazolodiazepines].
Archiv der Pharmazie 1991;324(3):141-8.
1990: Gerd Dannhardt; P Dominiak; Stefan Laufer
[Hypertensive acting 5-(beta-aminoethyl)aminoisoxazoles: synthesis and screening of derivatives with with partially rigid C-5 side chains and omega-position heterocyclics].
Archiv der Pharmazie 1990;323(9):571-8.
1990: Gerd Dannhardt; P Dominiak; Stefan Laufer
[Hypertensive action of 5-(omega-aminoalkyl)aminoisoxazole: synthesis and testing of compounds with a sulfamide or carboxyl group on the end of side chain].
Archiv der Pharmazie 1990;323(8):517-9.
1990: Gerd Dannhardt; T Kappe; W Meindl; B Schober
[Antimycobacterial acting 2-hydroxyquinolizin-4-ones].
Archiv der Pharmazie 1990;323(6):375-9.
1988: Gerd Dannhardt; Stefan Laufer; M Lehr
HPLC determination of etofenamate and flufenamic acid in biological material.
Clinical chemistry 1988;34(12):2580-1.
1988: Gerd Dannhardt; M Lehr
[Antiphlogistic 2,3-dihydro-1H-pyrrolizines. 14. Isomer arrangement of diaryldihydropyrrolizinyl-formic and -propionic acids].
Archiv der Pharmazie 1988;321(9):545-9.
1988: Gerd Dannhardt; M Lehr
[Anti-inflammatory 2,3-dihydro-1H-pyrrolizine. 13. Isomeric (diaryl-dihydropyrrolizinyl)acetic acids and 2-(diaryldihydropyrrolizinyl)-ethanols].
Archiv der Pharmazie 1988;321(3):159-62.