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Frederick Alt

This is a preview profile on BiomedExperts - the first literature-based scientific social network. It brings the right researchers together and allows them to collaborate online. Collexis and Dell provide the BiomedExperts network of +1.5 Million pre-calculated profiles free of charge to researchers worldwide.

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Immunoglobulin Genes

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Publications

TOP 3
Lee Yu Nee; Alt Frederick W; Reyes Julia; Gleason Megan; Zarrin Ali A; Jung David
Differential utilization of T cell receptor TCRalpha/TCRdelta locus variable region gene segments is mediated by accessibility.
Schwer Bjoern; Eckersdorff Mark; Li Yu; Silva Jeffrey C; Fermin Damian; Kurtev Martin V; Giallourakis Cosmas; Comb Michael J; Alt Frederick W; Lombard David B
Calorie restriction alters mitochondrial protein acetylation.
Zha Shan; Boboila Cristian; Alt Frederick W
Mre11: roles in DNA repair beyond homologous recombination.

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All Publications

2009: Lee Yu Nee; Alt Frederick W; Reyes Julia; Gleason Megan; Zarrin Ali A; Jung David
Differential utilization of T cell receptor TCRalpha/TCRdelta locus variable region gene segments is mediated by accessibility.
Proceedings of the National Academy of Sciences of the United States of America 2009;106(41):17487-92.
2009: Schwer Bjoern; Eckersdorff Mark; Li Yu; Silva Jeffrey C; Fermin Damian; Kurtev Martin V; Giallourakis Cosmas; Comb Michael J; Alt Frederick W; Lombard David B
Calorie restriction alters mitochondrial protein acetylation.
Aging cell 2009;8(5):604-6.
2009: Zha Shan; Boboila Cristian; Alt Frederick W
Mre11: roles in DNA repair beyond homologous recombination.
Nature structural & molecular biology 2009;16(8):798-800.
2009: Wang Jing H; Gostissa Monica; Yan Catherine T; Goff Peter; Hickernell Thomas; Hansen Erica; Difilippantonio Simone; Wesemann Duane R; Zarrin Ali A; Rajewsky Klaus; Nussenzweig Andre; Alt Frederick W
Mechanisms promoting translocations in editing and switching peripheral B cells.
Nature 2009;460(7252):231-6.
2009: Basu Uttiya; Franklin Andrew; Schwer Bjoern; Cheng Hwei-Ling; Chaudhuri Jayanta; Alt Frederick W
Regulation of activation-induced cytidine deaminase DNA deamination activity in B-cells by Ser38 phosphorylation.
Biochemical Society transactions 2009;37(Pt 3):561-8.
2009: Giblin William; Chatterji Monalisa; Westfield Gerwin; Masud Tehmina; Theisen Brian; Cheng Hwei-Ling; DeVido Jeffrey; Alt Frederick W; Ferguson David O; Schatz David G; Sekiguchi JoAnn
Leaky severe combined immunodeficiency and aberrant DNA rearrangements due to a hypomorphic RAG1 mutation.
Blood 2009;113(13):2965-75.
2009: Basu Uttiya; Franklin Andrew; Alt Frederick W
Post-translational regulation of activation-induced cytidine deaminase.
Philosophical transactions of the Royal Society of London. Series B, Biological sciences 2009;364(1517):667-73.
2009: Cheng Hwei-Ling; Vuong Bao Q; Basu Uttiya; Franklin Andrew; Schwer Bjoern; Astarita Jillian; Phan Ryan T; Datta Abhishek; Manis John; Alt Frederick W; Chaudhuri Jayanta
Integrity of the AID serine-38 phosphorylation site is critical for class switch recombination and somatic hypermutation in mice.
Proceedings of the National Academy of Sciences of the United States of America 2009;106(8):2717-22.
2009: Gostissa Monica; Ranganath Sheila; Bianco Julia M; Alt Frederick W
Chromosomal location targets different MYC family gene members for oncogenic translocations.
Proceedings of the National Academy of Sciences of the United States of America 2009;106(7):2265-70.
2009: Van Gool Frédéric; Gallí Mara; Gueydan Cyril; Kruys Véronique; Prevot Pierre-Paul; Bedalov Antonio; Mostoslavsky Raul; Alt Frederick W; De Smedt Thibaut; Leo Oberdan
Intracellular NAD levels regulate tumor necrosis factor protein synthesis in a sirtuin-dependent manner.
Nature medicine 2009;15(2):206-10.
2008: Oberdoerffer Philipp; Michan Shaday; McVay Michael; Mostoslavsky Raul; Vann James; Park Sang-Kyu; Hartlerode Andrea; Stegmuller Judith; Hafner Angela; Loerch Patrick; Wright Sarah M; Mills Kevin D; Bonni Azad; Yankner Bruce A; Scully Ralph; Prolla Tomas A; Alt Frederick W; Sinclair David A
SIRT1 redistribution on chromatin promotes genomic stability but alters gene expression during aging.
Cell 2008;135(5):907-18.
2008: Basu Uttiya; Wang Yabin; Alt Frederick W
Evolution of phosphorylation-dependent regulation of activation-induced cytidine deaminase.
Molecular cell 2008;32(2):285-91.
2008: Li Gang; Alt Frederick W; Cheng Hwei-Ling; Brush James W; Goff Peter H; Murphy Mike M; Franco Sonia; Zhang Yu; Zha Shan
Lymphocyte-specific compensation for XLF/cernunnos end-joining functions in V(D)J recombination.
Molecular cell 2008;31(5):631-40.
2008: Asher Gad; Gatfield David; Stratmann Markus; Reinke Hans; Dibner Charna; Kreppel Florian; Mostoslavsky Raul; Alt Frederick W; Schibler Ueli
SIRT1 regulates circadian clock gene expression through PER2 deacetylation.
Cell 2008;134(2):317-28.
2008: Zha Shan; Sekiguchi JoAnn; Brush James W; Bassing Craig H; Alt Frederick W
Complementary functions of ATM and H2AX in development and suppression of genomic instability.
Proceedings of the National Academy of Sciences of the United States of America 2008;105(27):9302-6.
2008: Chen Danica; Bruno Joanne; Easlon Erin; Lin Su-Ju; Cheng Hwei-Ling; Alt Frederick W; Guarente Leonard
Tissue-specific regulation of SIRT1 by calorie restriction.
Genes & development 2008;22(13):1753-7.
2008: Zarrin Ali A; Goff Peter H; Senger Kate; Alt Frederick W
Sgamma3 switch sequences function in place of endogenous Sgamma1 to mediate antibody class switching.
The Journal of experimental medicine 2008;205(7):1567-72.
2008: Walkley Carl R; Qudsi Rameez; Sankaran Vijay G; Perry Jennifer A; Gostissa Monica; Roth Sanford I; Rodda Stephen J; Snay Erin; Dunning Patricia; Fahey Frederic H; Alt Frederick W; McMahon Andrew P; Orkin Stuart H
Conditional mouse osteosarcoma, dependent on p53 loss and potentiated by loss of Rb, mimics the human disease.
Genes & development 2008;22(12):1662-76.
2008: Franco Sonia; Murphy Michael M; Li Gang; Borjeson Tiffany; Boboila Cristian; Alt Frederick W
DNA-PKcs and Artemis function in the end-joining phase of immunoglobulin heavy chain class switch recombination.
The Journal of experimental medicine 2008;205(3):557-64.
2008: Lee In Hye; Cao Liu; Mostoslavsky Raul; Lombard David B; Liu Jie; Bruns Nicholas E; Tsokos Maria; Alt Frederick W; Finkel Toren
A role for the NAD-dependent deacetylase Sirt1 in the regulation of autophagy.
Proceedings of the National Academy of Sciences of the United States of America 2008;105(9):3374-9.
2008: Perlot Thomas; Li Gang; Alt Frederick W
Antisense transcripts from immunoglobulin heavy-chain locus V(D)J and switch regions.
Proceedings of the National Academy of Sciences of the United States of America 2008;105(10):3843-8.
2008: Zhang Yu; Kwon Sohee; Yamaguchi Teppei; Cubizolles Fabien; Rousseaux Sophie; Kneissel Michaela; Cao Chun; Li Na; Cheng Hwei-Ling; Chua Katrin; Lombard David; Mizeracki Adam; Matthias Gabriele; Alt Frederick W; Khochbin Saadi; Matthias Patrick
Mice lacking histone deacetylase 6 have hyperacetylated tubulin but are viable and develop normally.
Molecular and cellular biology 2008;28(5):1688-701.
2008: Ranganath Sheila; Carpenter Andrea C; Gleason Megan; Shaw Albert C; Bassing Craig H; Alt Frederick W
Productive coupling of accessible Vbeta14 segments and DJbeta complexes determines the frequency of Vbeta14 rearrangement.
Journal of immunology (Baltimore, Md. : 1950) 2008;180(4):2339-46.
2008: Lombard D B; Schwer B; Alt F W; Mostoslavsky R
SIRT6 in DNA repair, metabolism and ageing.
Journal of internal medicine 2008;263(2):128-41.
2008: Jabara Haifa H; Chaudhuri Jayanta; Dutt Shilpee; Dedeoglu Fatma; Weng Yu; Murphy Michael M; Franco Sonia; Alt Fredrick W; Manis John; Geha Raif S
B-cell receptor cross-linking delays activation-induced cytidine deaminase induction and inhibits class-switch recombination to IgE.
The Journal of allergy and clinical immunology 2008;121(1):191-196.e2.
2008: Takeyama K; Monti S; Manis J P; Dal Cin P; Getz G; Beroukhim R; Dutt S; Aster J C; Alt F W; Golub T R; Shipp M A
Integrative analysis reveals 53BP1 copy loss and decreased expression in a subset of human diffuse large B-cell lymphomas.
Oncogene 2008;27(3):318-22.
2008: Perlot Thomas; Alt Frederick W
Cis-regulatory elements and epigenetic changes control genomic rearrangements of the IgH locus.
Advances in immunology 2008;99():1-32.
2007: Xie Anyong; Hartlerode Andrea; Stucki Manuel; Odate Shobu; Puget Nadine; Kwok Amy; Nagaraju Ganesh; Yan Catherine; Alt Frederick W; Chen Junjie; Jackson Stephen P; Scully Ralph
Distinct roles of chromatin-associated proteins MDC1 and 53BP1 in mammalian double-strand break repair.
Molecular cell 2007;28(6):1045-57.
2007: Lombard David B; Alt Frederick W; Cheng Hwei-Ling; Bunkenborg Jakob; Streeper Ryan S; Mostoslavsky Raul; Kim Jennifer; Yancopoulos George; Valenzuela David; Murphy Andrew; Yang Yinhua; Chen Yaohui; Hirschey Matthew D; Bronson Roderick T; Haigis Marcia; Guarente Leonard P; Farese Robert V; Weissman Sherman; Verdin Eric; Schwer Bjoern
Mammalian Sir2 homolog SIRT3 regulates global mitochondrial lysine acetylation.
Molecular and cellular biology 2007;27(24):8807-14.
2007: Wuerffel Robert; Wang Lili; Grigera Fernando; Manis John; Selsing Erik; Perlot Thomas; Alt Frederick W; Cogne Michel; Pinaud Eric; Kenter Amy L
S-S synapsis during class switch recombination is promoted by distantly located transcriptional elements and activation-induced deaminase.
Immunity 2007;27(5):711-22.
2007: Alt Frederick W
From gene amplification to V(D)J recombination and back: a personal account of my early years in B cell biology.
European journal of immunology 2007;37 Suppl 1():S138-47.
2007: Yan Catherine T; Boboila Cristian; Souza Ellen Kris; Franco Sonia; Hickernell Thomas R; Murphy Michael; Gumaste Sunil; Geyer Mark; Zarrin Ali A; Manis John P; Rajewsky Klaus; Alt Frederick W
IgH class switching and translocations use a robust non-classical end-joining pathway.
Nature 2007;449(7161):478-82.
2007: Zha Shan; Alt Frederick W; Cheng Hwei-Ling; Brush James W; Li Gang
Defective DNA repair and increased genomic instability in Cernunnos-XLF-deficient murine ES cells.
Proceedings of the National Academy of Sciences of the United States of America 2007;104(11):4518-23.
2007: Wu Cherry; Ranganath Sheila; Gleason Megan; Woodman Barbara B; Borjeson Tiffany M; Alt Frederick W; Bassing Craig H
Restriction of endogenous T cell antigen receptor beta rearrangements to Vbeta14 through selective recombination signal sequence modifications.
Proceedings of the National Academy of Sciences of the United States of America 2007;104(10):4002-7.
2007: Zarrin Ali A; Del Vecchio Catherine; Tseng Eva; Gleason Megan; Zarin Payam; Tian Ming; Alt Frederick W
Antibody class switching mediated by yeast endonuclease-generated DNA breaks.
Science (New York, N.Y.) 2007;315(5810):377-81.
2007: Chaudhuri Jayanta; Basu Uttiya; Zarrin Ali; Yan Catherine; Franco Sonia; Perlot Thomas; Vuong Bao; Wang Jing; Phan Ryan T; Datta Abhishek; Manis John; Alt Frederick W
Evolution of the immunoglobulin heavy chain class switch recombination mechanism.
Advances in immunology 2007;94():157-214.
2007: Basu Uttiya; Chaudhuri Jayanta; Phan Ryan T; Datta Abhishek; Alt Frederick W
Regulation of activation induced deaminase via phosphorylation.
Advances in experimental medicine and biology 2007;596():129-37.
2006: Haigis Marcia C; Mostoslavsky Raul; Haigis Kevin M; Fahie Kamau; Christodoulou Danos C; Murphy Andrew J; Valenzuela David M; Yancopoulos George D; Karow Margaret; Blander Gil; Wolberger Cynthia; Prolla Tomas A; Weindruch Richard; Alt Frederick W; Guarente Leonard
SIRT4 inhibits glutamate dehydrogenase and opposes the effects of calorie restriction in pancreatic beta cells.
Cell 2006;126(5):941-54.
2006: Franco Sonia; Alt Frederick W; Manis John P
Pathways that suppress programmed DNA breaks from progressing to chromosomal breaks and translocations.
DNA repair 2006;5(9-10):1030-41.
2006: Yan Catherine T; Kaushal Dhruv; Murphy Michael; Zhang Yu; Datta Abhishek; Chen Changzhong; Monroe Brianna; Mostoslavsky Gustavo; Coakley Kristen; Gao Yijie; Mills Kevin D; Fazeli Alex P; Tepsuporn Suprawee; Hall Giles; Mulligan Richard; Fox Edward; Bronson Roderick; De Girolami Umberto; Lee Charles; Alt Frederick W
XRCC4 suppresses medulloblastomas with recurrent translocations in p53-deficient mice.
Proceedings of the National Academy of Sciences of the United States of America 2006;103(19):7378-83.
2006: Longerich Simonne; Basu Uttiya; Alt Frederick; Storb Ursula
AID in somatic hypermutation and class switch recombination.
Current opinion in immunology 2006;18(2):164-74.
2006: Morales Julio C; Franco Sonia; Murphy Michael M; Bassing Craig H; Mills Kevin D; Adams Melissa M; Walsh Nicole C; Manis John P; Rassidakis George Z; Alt Frederick W; Carpenter Phillip B
53BP1 and p53 synergize to suppress genomic instability and lymphomagenesis.
Proceedings of the National Academy of Sciences of the United States of America 2006;103(9):3310-5.
2006: Franco Sonia; Gostissa Monica; Zha Shan; Lombard David B; Murphy Michael M; Zarrin Ali A; Yan Catherine; Tepsuporn Suprawee; Morales Julio C; Adams Melissa M; Lou Zhenkun; Bassing Craig H; Manis John P; Chen Junjie; Carpenter Phillip B; Alt Frederick W
H2AX prevents DNA breaks from progressing to chromosome breaks and translocations.
Molecular cell 2006;21(2):201-14.
2006: Lou Zhenkun; Minter-Dykhouse Katherine; Franco Sonia; Gostissa Monica; Rivera Melissa A; Celeste Arkady; Manis John P; van Deursen Jan; Nussenzweig André; Paull Tanya T; Alt Frederick W; Chen Junjie
MDC1 maintains genomic stability by participating in the amplification of ATM-dependent DNA damage signals.
Molecular cell 2006;21(2):187-200.
2006: O'Neil Jennifer; Calvo Jennifer; McKenna Keith; Krishnamoorthy Veena; Aster Jon C; Bassing Craig H; Alt Frederick W; Kelliher Michelle; Look A Thomas
Activating Notch1 mutations in mouse models of T-ALL.
Blood 2006;107(2):781-5.
2006: Jung David; Giallourakis Cosmas; Mostoslavsky Raul; Alt Frederick W
Mechanism and control of V(D)J recombination at the immunoglobulin heavy chain locus.
Annual review of immunology 2006;24():541-70.
2005: Basu Uttiya; Chaudhuri Jayanta; Alpert Craig; Dutt Shilpee; Ranganath Sheila; Li Gang; Schrum Jason Patrick; Manis John P; Alt Frederick W
The AID antibody diversification enzyme is regulated by protein kinase A phosphorylation.
Nature 2005;438(7067):508-11.
2005: Perlot Thomas; Alt Frederick W; Bassing Craig H; Suh Heikyung; Pinaud Eric
Elucidation of IgH intronic enhancer functions via germ-line deletion.
Proceedings of the National Academy of Sciences of the United States of America 2005;102(40):14362-7.
2005: Chua Katrin F; Mostoslavsky Raul; Lombard David B; Pang Wendy W; Saito Shin'ichi; Franco Sonia; Kaushal Dhruv; Cheng Hwei-Ling; Fischer Miriam R; Stokes Nicole; Murphy Michael M; Appella Ettore; Alt Frederick W
Mammalian SIRT1 limits replicative life span in response to chronic genotoxic stress.
Cell metabolism 2005;2(1):67-76.
2005: Lombard David B; Chua Katrin F; Mostoslavsky Raul; Franco Sonia; Gostissa Monica; Alt Frederick W
DNA repair, genome stability, and aging.
Cell 2005;120(4):497-512.
2005: Rooney Sean; Alt Frederick W; Sekiguchi JoAnn; Manis John P
Artemis-independent functions of DNA-dependent protein kinase in Ig heavy chain class switch recombination and development.
Proceedings of the National Academy of Sciences of the United States of America 2005;102(7):2471-5.
2005: Zarrin Ali A; Tian Ming; Wang Jing; Borjeson Tiffany; Alt Frederick W
Influence of switch region length on immunoglobulin class switch recombination.
Proceedings of the National Academy of Sciences of the United States of America 2005;102(7):2466-70.
2005: Kang Jian; Ferguson David; Song Hoseok; Bassing Craig; Eckersdorff Mark; Alt Frederick W; Xu Yang
Functional interaction of H2AX, NBS1, and p53 in ATM-dependent DNA damage responses and tumor suppression.
Molecular and cellular biology 2005;25(2):661-70.
2005: Dudley Darryll D; Chaudhuri Jayanta; Bassing Craig H; Alt Frederick W
Mechanism and control of V(D)J recombination versus class switch recombination: similarities and differences.
Advances in immunology 2005;86():43-112.
2004: Xie Anyong; Puget Nadine; Shim Inbo; Odate Shobu; Jarzyna Ingeborga; Bassing Craig H; Alt Frederick W; Scully Ralph
Control of sister chromatid recombination by histone H2AX.
Molecular cell 2004;16(6):1017-25.
2004: Zarrin Ali A; Alt Frederick W; Chaudhuri Jayanta; Stokes Nicole; Kaushal Dhruv; Du Pasquier Louis; Tian Ming
An evolutionarily conserved target motif for immunoglobulin class-switch recombination.
Nature immunology 2004;5(12):1275-81.
2004: Ansel K Mark; Greenwald Rebecca J; Agarwal Suneet; Bassing Craig H; Monticelli Silvia; Interlandi Jeneen; Djuretic Ivana M; Lee Dong U; Sharpe Arlene H; Alt Frederick W; Rao Anjana
Deletion of a conserved Il4 silencer impairs T helper type 1-mediated immunity.
Nature immunology 2004;5(12):1251-9.
2004: Mostoslavsky Raul; Alt Frederick W; Rajewsky Klaus
The lingering enigma of the allelic exclusion mechanism.
Cell 2004;118(5):539-44.
2004: Chaudhuri Jayanta; Khuong Chan; Alt Frederick W
Replication protein A interacts with AID to promote deamination of somatic hypermutation targets.
Nature 2004;430(7003):992-8.
2004: Rooney Sean; Chaudhuri Jayanta; Alt Frederick W
The role of the non-homologous end-joining pathway in lymphocyte development.
Immunological reviews 2004;200():115-31.
2004: Senoo Makoto; Manis John P; Alt Frederick W; McKeon Frank
p63 and p73 are not required for the development and p53-dependent apoptosis of T cells.
Cancer cell 2004;6(1):85-9.
2004: Couëdel Chrystelle; Mills Kevin D; Barchi Marco; Shen Lingbo; Olshen Adam; Johnson Roger D; Nussenzweig André; Essers Jeroen; Kanaar Roland; Li Gloria C; Alt Frederick W; Jasin Maria
Collaboration of homologous recombination and nonhomologous end-joining factors for the survival and integrity of mice and cells.
Genes & development 2004;18(11):1293-304.
2004: Mills Kevin D; Ferguson David O; Essers Jeroen; Eckersdorff Mark; Kanaar Roland; Alt Frederick W
Rad54 and DNA Ligase IV cooperate to maintain mammalian chromatid stability.
Genes & development 2004;18(11):1283-92.
2004: Giallourakis Cosmas; Alt Frederick W; Bassing Craig H
V(D)J recombinational accessibility-heading in the opposite direction?
Nature immunology 2004;5(6):561-2.
2004: Mostoslavsky Raul; Alt Frederick W
Receptor revision in T cells: an open question?
Trends in immunology 2004;25(6):276-9.
2004: Manis John P; Morales Julio C; Xia Zhenfang; Kutok Jeffery L; Alt Frederick W; Carpenter Phillip B
53BP1 links DNA damage-response pathways to immunoglobulin heavy chain class-switch recombination.
Nature immunology 2004;5(5):481-7.
2004: Brunet Anne; Sweeney Lora B; Sturgill J Fitzhugh; Chua Katrin F; Greer Paul L; Lin Yingxi; Tran Hien; Ross Sarah E; Mostoslavsky Raul; Cohen Haim Y; Hu Linda S; Cheng Hwei-Ling; Jedrychowski Mark P; Gygi Steven P; Sinclair David A; Alt Frederick W; Greenberg Michael E
Stress-dependent regulation of FOXO transcription factors by the SIRT1 deacetylase.
Science (New York, N.Y.) 2004;303(5666):2011-5.
2004: Rooney Sean; Sekiguchi JoAnn; Whitlow Scott; Eckersdorff Mark; Manis John P; Lee Charles; Ferguson David O; Alt Frederick W
Artemis and p53 cooperate to suppress oncogenic N-myc amplification in progenitor B cells.
Proceedings of the National Academy of Sciences of the United States of America 2004;101(8):2410-5.
2004: Jung David; Alt Frederick W
Unraveling V(D)J recombination; insights into gene regulation.
Cell 2004;116(2):299-311.
2004: Talukder Sadiqur R; Dudley Darryll D; Alt Frederick W; Takahama Yousuke; Akamatsu Yoshiko
Increased frequency of aberrant V(D)J recombination products in core RAG-expressing mice.
Nucleic acids research 2004;32(15):4539-49.
2003: Theunissen Jan-Willem F; Kaplan Mark I; Hunt Patricia A; Williams Bret R; Ferguson David O; Alt Frederick W; Petrini John H J
Checkpoint failure and chromosomal instability without lymphomagenesis in Mre11(ATLD1/ATLD1) mice.
Molecular cell 2003;12(6):1511-23.
2003: Pivniouk Vadim I; Snapper Scott B; Kettner Alexander; Alenius Harri; Laouini Dhafer; Falet Hervé; Hartwig John; Alt Frederick W; Geha Raif S
Impaired signaling via the high-affinity IgE receptor in Wiskott-Aldrich syndrome protein-deficient mast cells.
International immunology 2003;15(12):1431-40.
2003: Fujikawa Keiko; Miletic Ana V; Alt Frederick W; Faccio Roberta; Brown Tracie; Hoog Jeremy; Fredericks Jessica; Nishi Shinzo; Mildiner Shirly; Moores Sheri L; Brugge Joan; Rosen Fred S; Swat Wojciech
Vav1/2/3-null mice define an essential role for Vav family proteins in lymphocyte development and activation but a differential requirement in MAPK signaling in T and B cells.
The Journal of experimental medicine 2003;198(10):1595-608.
2003: Dudley Darryll D; Sekiguchi JoAnn; Zhu Chengming; Sadofsky Moshe J; Whitlow Scott; DeVido Jeffrey; Monroe Robert J; Bassing Craig H; Alt Frederick W
Impaired V(D)J recombination and lymphocyte development in core RAG1-expressing mice.
The Journal of experimental medicine 2003;198(9):1439-50.
2003: Cheng Hwei-Ling; Mostoslavsky Raul; Saito Shin'ichi; Manis John P; Gu Yansong; Patel Parin; Bronson Roderick; Appella Ettore; Alt Frederick W; Chua Katrin F
Developmental defects and p53 hyperacetylation in Sir2 homolog (SIRT1)-deficient mice.
Proceedings of the National Academy of Sciences of the United States of America 2003;100(19):10794-9.
2003: Bassing Craig H; Suh Heikyung; Ferguson David O; Chua Katrin F; Manis John; Eckersdorff Mark; Gleason Megan; Bronson Rodrick; Lee Charles; Alt Frederick W
Histone H2AX: a dosage-dependent suppressor of oncogenic translocations and tumors.
Cell 2003;114(3):359-70.
2003: Mills Kevin D; Ferguson David O; Alt Frederick W
The role of DNA breaks in genomic instability and tumorigenesis.
Immunological reviews 2003;194():77-95.
2003: Manis John P; Alt Frederick W
Novel antibody switching defects in human patients.
The Journal of clinical investigation 2003;112(1):19-22.
2003: Mostoslavsky Raul; Alt Frederick W; Bassing Craig H
Chromatin dynamics and locus accessibility in the immune system.
Nature immunology 2003;4(7):603-6.
2003: Shinkura Reiko; Tian Ming; Smith Michele; Chua Katrin; Fujiwara Yuko; Alt Frederick W
The influence of transcriptional orientation on endogenous switch region function.
Nature immunology 2003;4(5):435-41.
2003: Chaudhuri Jayanta; Tian Ming; Khuong Chan; Chua Katrin; Pinaud Eric; Alt Frederick W
Transcription-targeted DNA deamination by the AID antibody diversification enzyme.
Nature 2003;422(6933):726-30.
2003: Rooney Sean; Alt Frederick W; Lombard David; Whitlow Scott; Eckersdorff Mark; Fleming James; Fugmann Sebastian; Ferguson David O; Schatz David G; Sekiguchi JoAnn
Defective DNA repair and increased genomic instability in Artemis-deficient murine cells.
The Journal of experimental medicine 2003;197(5):553-65.
2003: Bassing Craig H; Tillman Robert E; Woodman Barbara B; Canty David; Monroe Robert J; Sleckman Barry P; Alt Frederick W
T cell receptor (TCR) alpha/delta locus enhancer identity and position are critical for the assembly of TCR delta and alpha variable region genes.
Proceedings of the National Academy of Sciences of the United States of America 2003;100(5):2598-603.
2003: Klein Christoph; Nguyen Deanna; Liu Ching-Hui; Mizoguchi Atsushi; Bhan Atul K; Miki Hiroaki; Takenawa Tadaomi; Rosen Fred S; Alt Fred W; Mulligan Richard C; Snapper Scott B
Gene therapy for Wiskott-Aldrich syndrome: rescue of T-cell signaling and amelioration of colitis upon transplantation of retrovirally transduced hematopoietic stem cells in mice.
Blood 2003;101(6):2159-66.
2003: Swat Wojciech; Xavier Ramnik; Mizoguchi Atsushi; Mizoguchi Emiko; Fredericks Jessica; Fujikawa Keiko; Bhan Atul K; Alt Frederick W
Essential role for Vav1 in activation, but not development, of gammadelta T cells.
International immunology 2003;15(2):215-21.
2003: Wong Kwok-Kin; Maser Richard S; Bachoo Robert M; Menon Jayant; Carrasco Daniel R; Gu Yansong; Alt Frederick W; DePinho Ronald A
Telomere dysfunction and Atm deficiency compromises organ homeostasis and accelerates ageing.
Nature 2003;421(6923):643-8.
2003: Akamatsu Yoshiko; Monroe Robert; Dudley Darryll D; Elkin Sheryl K; Gartner Frank; Talukder Sadiqur R; Takahama Yousuke; Alt Frederick W; Bassing Craig H; Oettinger Marjorie A
Deletion of the RAG2 C terminus leads to impaired lymphoid development in mice.
Proceedings of the National Academy of Sciences of the United States of America 2003;100(3):1209-14.
2003: Zinkel Sandra S; Ong Christy C; Ferguson David O; Iwasaki Hiromi; Akashi Koichi; Bronson Roderick T; Kutok Jeffery L; Alt Frederick W; Korsmeyer Stanley J
Proapoptotic BID is required for myeloid homeostasis and tumor suppression.
Genes & development 2003;17(2):229-39.
2003: Manis John P; Michaelson Jennifer S; Birshtein Barbara K; Alt Frederick W
Elucidation of a downstream boundary of the 3' IgH regulatory region.
Molecular immunology 2003;39(12):753-60.
2003: Wu Cherry; Bassing Craig H; Jung David; Woodman Barbara B; Foy Dan; Alt Frederick W
Dramatically increased rearrangement and peripheral representation of Vbeta14 driven by the 3'Dbeta1 recombination signal sequence.
Immunity 2003;18(1):75-85.
2003: Jung David; Bassing Craig H; Fugmann Sebastian D; Cheng Hwei-Ling; Schatz David G; Alt Frederick W
Extrachromosomal recombination substrates recapitulate beyond 12/23 restricted VDJ recombination in nonlymphoid cells.
Immunity 2003;18(1):65-74.
2002: Rooney Sean; Sekiguchi JoAnn; Zhu Chengming; Cheng Hwei Ling; Manis John; Whitlow Scott; DeVido Jeff; Foy Dan; Chaudhuri Jayanta; Lombard David; Alt Frederick W
Leaky Scid phenotype associated with defective V(D)J coding end processing in Artemis-deficient mice.
Molecular cell 2002;10(6):1379-90.
2002: Yang Xiao-Feng; Ye Qunrui; Press Barry; Han Rui-Zhu; Bassing Craig H; Sleckman Barry P; Alt Frederick W; Cantor Harvey
Analysis of the complex genomic structure of Bcl-x and its relationship to Bcl-x(gamma) expression after CD28-dependent costimulation.
Molecular immunology 2002;39(1-2):45-55.
2002: Solymar Deborah C; Agarwal Suneet; Bassing Craig H; Alt Frederick W; Rao Anjana
A 3' enhancer in the IL-4 gene regulates cytokine production by Th2 cells and mast cells.
Immunity 2002;17(1):41-50.
2002: Dudley Darryll D; Manis John P; Zarrin Ali A; Kaylor Lianne; Tian Ming; Alt Frederick W
Internal IgH class switch region deletions are position-independent and enhanced by AID expression.
Proceedings of the National Academy of Sciences of the United States of America 2002;99(15):9984-9.
2002: Ye Qunrui; Press Barry; Kissler Stephan; Yang Xiao-Feng; Lu Linrong; Bassing Craig H; Sleckman Barry P; Jansson Marianne; Panoutsakopoulou Vily; Trimble Linda A; Alt Frederick W; Cantor Harvey
T cell costimulation through CD28 depends on induction of the Bcl-xgamma isoform: analysis of Bcl-xgamma-deficient mice.
The Journal of experimental medicine 2002;196(1):87-95.
2002: Zhu Chengming; Mills Kevin D; Ferguson David O; Lee Charles; Manis John; Fleming James; Gao Yijie; Morton Cynthia C; Alt Frederick W
Unrepaired DNA breaks in p53-deficient cells lead to oncogenic gene amplification subsequent to translocations.
Cell 2002;109(7):811-21.
2002: Bassing Craig H; Chua Katrin F; Sekiguchi JoAnn; Suh Heikyung; Whitlow Scott R; Fleming James C; Monroe Brianna C; Ciccone David N; Yan Catherine; Vlasakova Katerina; Livingston David M; Ferguson David O; Scully Ralph; Alt Frederick W
Increased ionizing radiation sensitivity and genomic instability in the absence of histone H2AX.
Proceedings of the National Academy of Sciences of the United States of America 2002;99(12):8173-8.
2002: Chua Katrin F; Alt Frederick W; Manis John P
The function of AID in somatic mutation and class switch recombination: upstream or downstream of DNA breaks.
The Journal of experimental medicine 2002;195(9):F37-41.
2002: Inlay Matthew; Alt Frederick W; Baltimore David; Xu Yang
Essential roles of the kappa light chain intronic enhancer and 3' enhancer in kappa rearrangement and demethylation.
Nature immunology 2002;3(5):463-8.
2002: Bassing Craig H; Swat Wojciech; Alt Frederick W
The mechanism and regulation of chromosomal V(D)J recombination.
Cell 2002;109 Suppl():S45-55.
2002: Manis John P; Dudley Darryll; Kaylor Lianne; Alt Frederick W
IgH class switch recombination to IgG1 in DNA-PKcs-deficient B cells.
Immunity 2002;16(4):607-17.
2002: Malynn Barbara A; Shaw Albert C; Young Faith; Stewart Valerie; Alt Frederick W
Truncated immunoglobulin Dmu causes incomplete developmental progression of RAG-deficient pro-B cells.
Molecular immunology 2002;38(7):547-56.
2001: Sharpless N E; Ferguson D O; O'Hagan R C; Castrillon D H; Lee C; Farazi P A; Alson S; Fleming J; Morton C C; Frank K; Chin L; Alt F W; DePinho R A
Impaired nonhomologous end-joining provokes soft tissue sarcomas harboring chromosomal translocations, amplifications, and deletions.
Molecular cell 2001;8(6):1187-96.
2001: Tsitsikov E N; Laouini D; Dunn I F; Sannikova T Y; Davidson L; Alt F W; Geha R S
TRAF1 is a negative regulator of TNF signaling. enhanced TNF signaling in TRAF1-deficient mice.
Immunity 2001;15(4):647-57.
2001: Ferguson D O; Alt F W
DNA double strand break repair and chromosomal translocation: lessons from animal models.
Oncogene 2001;20(40):5572-9.
2001: Sekiguchi J; Ferguson D O; Chen H T; Yang E M; Earle J; Frank K; Whitlow S; Gu Y; Xu Y; Nussenzweig A; Alt F W
Genetic interactions between ATM and the nonhomologous end-joining factors in genomic stability and development.
Proceedings of the National Academy of Sciences of the United States of America 2001;98(6):3243-8.
2001: de Alboran I M; O'Hagan R C; Gärtner F; Malynn B; Davidson L; Rickert R; Rajewsky K; DePinho R A; Alt F W
Analysis of C-MYC function in normal cells via conditional gene-targeted mutation.
Immunity 2001;14(1):45-55.
2000: Gärtner F; Alt F W; Monroe R J; Seidl K J
Antigen-independent appearance of recombination activating gene (RAG)-positive bone marrow B cells in the spleens of immunized mice.
The Journal of experimental medicine 2000;192(12):1745-54.
2000: Wong K K; Chang S; Weiler S R; Ganesan S; Chaudhuri J; Zhu C; Artandi S E; Rudolph K L; Gottlieb G J; Chin L; Alt F W; DePinho R A
Telomere dysfunction impairs DNA repair and enhances sensitivity to ionizing radiation.
Nature genetics 2000;26(1):85-8.
2000: O'Hagan R C; Ohh M; David G; de Alboran I M; Alt F W; Kaelin W G; DePinho R A
Myc-enhanced expression of Cul1 promotes ubiquitin-dependent proteolysis and cell cycle progression.
Genes & development 2000;14(17):2185-91.
2000: Moores S L; Selfors L M; Fredericks J; Breit T; Fujikawa K; Alt F W; Brugge J S; Swat W
Vav family proteins couple to diverse cell surface receptors.
Molecular and cellular biology 2000;20(17):6364-73.
2000: Tian M; Alt F W
Transcription-induced cleavage of immunoglobulin switch regions by nucleotide excision repair nucleases in vitro.
The Journal of biological chemistry 2000;275(31):24163-72.
2000: Sleckman B P; Bassing C H; Hughes M M; Okada A; D'Auteuil M; Wehrly T D; Woodman B B; Davidson L; Chen J; Alt F W
Mechanisms that direct ordered assembly of T cell receptor beta locus V, D, and J gene segments.
Proceedings of the National Academy of Sciences of the United States of America 2000;97(14):7975-80.
2000: Frank K M; Sharpless N E; Gao Y; Sekiguchi J M; Ferguson D O; Zhu C; Manis J P; Horner J; DePinho R A; Alt F W
DNA ligase IV deficiency in mice leads to defective neurogenesis and embryonic lethality via the p53 pathway.
Molecular cell 2000;5(6):993-1002.
2000: Bassing C H; Alt F W; Hughes M M; D'Auteuil M; Wehrly T D; Woodman B B; Gärtner F; White J M; Davidson L; Sleckman B P
Recombination signal sequences restrict chromosomal V(D)J recombination beyond the 12/23 rule.
Nature 2000;405(6786):583-6.
2000: Malynn B A; de Alboran I M; O'Hagan R C; Bronson R; Davidson L; DePinho R A; Alt F W
N-myc can functionally replace c-myc in murine development, cellular growth, and differentiation.
Genes & development 2000;14(11):1390-9.
2000: Sleckman B P; Khan W N; Xu W; Bassing C H; Malynn B A; Copeland N G; Bardon C G; Breit T M; Davidson L; Oltz E M; Jenkins N A; Berman J E; Alt F W
Cloning and functional characterization of the early-lymphocyte-specific Pb99 gene.
Molecular and cellular biology 2000;20(12):4405-10.
2000: Ferguson D O; Sekiguchi J M; Chang S; Frank K M; Gao Y; DePinho R A; Alt F W
The nonhomologous end-joining pathway of DNA repair is required for genomic stability and the suppression of translocations.
Proceedings of the National Academy of Sciences of the United States of America 2000;97(12):6630-3.
2000: Gao Y; Ferguson D O; Xie W; Manis J P; Sekiguchi J; Frank K M; Chaudhuri J; Horner J; DePinho R A; Alt F W
Interplay of p53 and DNA-repair protein XRCC4 in tumorigenesis, genomic stability and development.
Nature 2000;404(6780):897-900.
2000: Gu Y; Sekiguchi J; Gao Y; Dikkes P; Frank K; Ferguson D; Hasty P; Chun J; Alt F W
Defective embryonic neurogenesis in Ku-deficient but not DNA-dependent protein kinase catalytic subunit-deficient mice.
Proceedings of the National Academy of Sciences of the United States of America 2000;97(6):2668-73.
2000: Borghesani P R; Alt F W; Bottaro A; Davidson L; Aksoy S; Rathbun G A; Roberts T M; Swat W; Segal R A; Gu Y
Abnormal development of Purkinje cells and lymphocytes in Atm mutant mice.
Proceedings of the National Academy of Sciences of the United States of America 2000;97(7):3336-41.
2000: Ferguson D O; Sekiguchi J M; Frank K M; Gao Y; Sharpless N E; Gu Y; Manis J; DePinho R A; Alt F W
The interplay between nonhomologous end-joining and cell cycle checkpoint factors in development, genomic stability, and tumorigenesis.
Cold Spring Harbor symposia on quantitative biology 2000;65():395-403.
1999: Monroe R J; Chen F; Ferrini R; Davidson L; Alt F W
RAG2 is regulated differentially in B and T cells by elements 5' of the promoter.
Proceedings of the National Academy of Sciences of the United States of America 1999;96(22):12713-8.
1999: Aifantis I; Pivniouk V I; Gärtner F; Feinberg J; Swat W; Alt F W; von Boehmer H; Geha R S
Allelic exclusion of the T cell receptor beta locus requires the SH2 domain-containing leukocyte protein (SLP)-76 adaptor protein.
The Journal of experimental medicine 1999;190(8):1093-102.
1999: Sakai E; Bottaro A; Alt F W
The Ig heavy chain intronic enhancer core region is necessary and sufficient to promote efficient class switch recombination.
International immunology 1999;11(10):1709-13.
1999: Monroe R J; Seidl K J; Gaertner F; Han S; Chen F; Sekiguchi J; Wang J; Ferrini R; Davidson L; Kelsoe G; Alt F W
RAG2:GFP knockin mice reveal novel aspects of RAG2 expression in primary and peripheral lymphoid tissues.
Immunity 1999;11(2):201-12.
1999: Wang Z; Yunis D; Irigoyen M; Kitchens B; Bottaro A; Alt F W; Alper C A
Discordance between IgA switching at the DNA level and IgA expression at the mRNA level in IgA-deficient patients.
Clinical immunology (Orlando, Fla.) 1999;91(3):263-70.
1999: Gärtner F; Alt F W; Monroe R; Chu M; Sleckman B P; Davidson L; Swat W
Immature thymocytes employ distinct signaling pathways for allelic exclusion versus differentiation and expansion.
Immunity 1999;10(5):537-46.
1999: Monroe R J; Sleckman B P; Monroe B C; Khor B; Claypool S; Ferrini R; Davidson L; Alt F W
Developmental regulation of TCR delta locus accessibility and expression by the TCR delta enhancer.
Immunity 1999;10(5):503-13.
1999: Seidl K J; Manis J P; Bottaro A; Zhang J; Davidson L; Kisselgof A; Oettgen H; Alt F W
Position-dependent inhibition of class-switch recombination by PGK-neor cassettes inserted into the immunoglobulin heavy chain constant region locus.
Proceedings of the National Academy of Sciences of the United States of America 1999;96(6):3000-5.
1999: Shaw A C; Swat W; Davidson L; Alt F W
Induction of Ig light chain gene rearrangement in heavy chain-deficient B cells by activated Ras.
Proceedings of the National Academy of Sciences of the United States of America 1999;96(5):2239-43.
1999: Sakai E; Bottaro A; Davidson L; Sleckman B P; Alt F W
Recombination and transcription of the endogenous Ig heavy chain locus is effected by the Ig heavy chain intronic enhancer core region in the absence of the matrix attachment regions.
Proceedings of the National Academy of Sciences of the United States of America 1999;96(4):1526-31.
1999: Shaw A C; Swat W; Ferrini R; Davidson L; Alt F W
Activated Ras signals developmental progression of recombinase-activating gene (RAG)-deficient pro-B lymphocytes.
The Journal of experimental medicine 1999;189(1):123-9.
1999: Sekiguchi J M; Gao Y; Gu Y; Frank K; Sun Y; Chaudhuri J; Zhu C; Cheng H L; Manis J; Ferguson D; Davidson L; Greenberg M E; Alt F W
Nonhomologous end-joining proteins are required for V(D)J recombination, normal growth, and neurogenesis.
Cold Spring Harbor symposia on quantitative biology 1999;64():169-81.
1998: Gao Y; Sun Y; Frank K M; Dikkes P; Fujiwara Y; Seidl K J; Sekiguchi J M; Rathbun G A; Swat W; Wang J; Bronson R T; Malynn B A; Bryans M; Zhu C; Chaudhuri J; Davidson L; Ferrini R; Stamato T; Orkin S H; Greenberg M E; Alt F W
A critical role for DNA end-joining proteins in both lymphogenesis and neurogenesis.
Cell 1998;95(7):891-902.
1998: Seidl K J; Bottaro A; Vo A; Zhang J; Davidson L; Alt F W
An expressed neo(r) cassette provides required functions of the 1gamma2b exon for class switching.
International immunology 1998;10(11):1683-92.
1998: Frank K M; Sekiguchi J M; Seidl K J; Swat W; Rathbun G A; Cheng H L; Davidson L; Kangaloo L; Alt F W
Late embryonic lethality and impaired V(D)J recombination in mice lacking DNA ligase IV.
Nature 1998;396(6707):173-7.
1998: Sleckman B P; Bassing C H; Bardon C G; Okada A; Khor B; Bories J C; Monroe R; Alt F W
Accessibility control of variable region gene assembly during T-cell development.
Immunological reviews 1998;165():121-30.
1998: Sleckman B P; Khor B; Monroe R; Alt F W
Assembly of productive T cell receptor delta variable region genes exhibits allelic inclusion.
The Journal of experimental medicine 1998;188(8):1465-71.
1998: Manis J P; van der Stoep N; Tian M; Ferrini R; Davidson L; Bottaro A; Alt F W
Class switching in B cells lacking 3' immunoglobulin heavy chain enhancers.
The Journal of experimental medicine 1998;188(8):1421-31.
1998: Gao Y; Chaudhuri J; Zhu C; Davidson L; Weaver D T; Alt F W
A targeted DNA-PKcs-null mutation reveals DNA-PK-independent functions for KU in V(D)J recombination.
Immunity 1998;9(3):367-76.
1998: Cunningham K; Ackerly H; Claflin L; Collins J; Wu P; Ford C; Lansford R; Alt F; Dunnick W A
Germline transcription and recombination of a murine VDJmudeltagamma1 transgene.
International immunology 1998;10(8):1027-37.
1998: Wang L C; Swat W; Fujiwara Y; Davidson L; Visvader J; Kuo F; Alt F W; Gilliland D G; Golub T R; Orkin S H
The TEL/ETV6 gene is required specifically for hematopoiesis in the bone marrow.
Genes & development 1998;12(15):2392-402.
1998: Snapper S B; Rosen F S; Mizoguchi E; Cohen P; Khan W; Liu C H; Hagemann T L; Kwan S P; Ferrini R; Davidson L; Bhan A K; Alt F W
Wiskott-Aldrich syndrome protein-deficient mice reveal a role for WASP in T but not B cell activation.
Immunity 1998;9(1):81-91.
1998: Pivniouk V; Tsitsikov E; Swinton P; Rathbun G; Alt F W; Geha R S
Impaired viability and profound block in thymocyte development in mice lacking the adaptor protein SLP-76.
Cell 1998;94(2):229-38.
1998: Bottaro A; Young F; Chen J; Serwe M; Sablitzky F; Alt F W
Deletion of the IgH intronic enhancer and associated matrix-attachment regions decreases, but does not abolish, class switching at the mu locus.
International immunology 1998;10(6):799-806.
1998: Manis J P; Gu Y; Lansford R; Sonoda E; Ferrini R; Davidson L; Rajewsky K; Alt F W
Ku70 is required for late B cell development and immunoglobulin heavy chain class switching.
The Journal of experimental medicine 1998;187(12):2081-9.
1998: Swat W; Fujikawa K; Ganiatsas S; Yang D; Xavier R J; Harris N L; Davidson L; Ferrini R; Davis R J; Labow M A; Flavell R A; Zon L I; Alt F W
SEK1/MKK4 is required for maintenance of a normal peripheral lymphoid compartment but not for lymphocyte development.
Immunity 1998;8(5):625-34.
1998: Irving B A; Alt F W; Killeen N
Thymocyte development in the absence of pre-T cell receptor extracellular immunoglobulin domains.
Science (New York, N.Y.) 1998;280(5365):905-8.
1998: Cunningham K; Ackerly H; Alt F; Dunnick W
Potential regulatory elements for germline transcription in or near murine Sgamma1.
International immunology 1998;10(4):527-36.
1998: Lansford R; Manis J P; Sonoda E; Rajewsky K; Alt F W
Ig heavy chain class switching in Rag-deficient mice.
International immunology 1998;10(3):325-32.
1998: Gorman J R; Alt F W
Regulation of immunoglobulin light chain isotype expression.
Advances in immunology 1998;69():113-81.
1997: Gu Y; Seidl K J; Rathbun G A; Zhu C; Manis J P; van der Stoep N; Davidson L; Cheng H L; Sekiguchi J M; Frank K; Stanhope-Baker P; Schlissel M S; Roth D B; Alt F W
Growth retardation and leaky SCID phenotype of Ku70-deficient mice.
Immunity 1997;7(5):653-65.
1997: Sleckman B P; Bardon C G; Ferrini R; Davidson L; Alt F W
Function of the TCR alpha enhancer in alphabeta and gammadelta T cells.
Immunity 1997;7(4):505-15.
1997: Mizuta R; Cheng H L; Gao Y; Alt F W
Molecular genetic characterization of XRCC4 function.
International immunology 1997;9(10):1607-13.
1997: Gu Y; Jin S; Gao Y; Weaver D T; Alt F W
Ku70-deficient embryonic stem cells have increased ionizing radiosensitivity, defective DNA end-binding activity, and inability to support V(D)J recombination.
Proceedings of the National Academy of Sciences of the United States of America 1997;94(15):8076-81.
1997: Mizuta R; LaSalle J M; Cheng H L; Shinohara A; Ogawa H; Copeland N; Jenkins N A; Lalande M; Alt F W
RAB22 and RAB163/mouse BRCA2: proteins that specifically interact with the RAD51 protein.
Proceedings of the National Academy of Sciences of the United States of America 1997;94(13):6927-32.
1997: Young F; Mizoguchi E; Bhan A K; Alt F W
Constitutive Bcl-2 expression during immunoglobulin heavy chain-promoted B cell differentiation expands novel precursor B cells.
Immunity 1997;6(1):23-33.

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