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Frederick Alt

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Monica Gostissa; Jeffery L Kutok; Daniel J Malkin; Herbert C Morse; Scott J Rodig; Craig H Bassing; Julia M Bianco; Frederick W Alt
Conditional inactivation of p53 in mature B cells promotes generation of nongerminal center-derived B-cell lymphomas.
Valentyn Oksenych; Bjoern Schwer; Shan Zha; Chunguang Guo; Vipul Kumar; Xiangyu Liu; Frederick W Alt
Functional redundancy between the XLF and DNA-PKcs DNA repair factors in V(D)J recombination and nonhomologous DNA end joining.
John J Garber; Raif S Geha; Archana Kapoor; John M Leong; Anna Lyubimova; Michiko K Oyoshi; Tomoyuki Shibata; Frederick W Alt; Inés M Antón; Feng Chen; Fuminao Takeshima; Scott B Snapper
Enteropathogenic Escherichia coli and vaccinia virus do not require the family of WASP-interacting proteins for pathogen-induced actin assembly.

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2013: Monica Gostissa; Jeffery L Kutok; Daniel J Malkin; Herbert C Morse; Scott J Rodig; Craig H Bassing; Julia M Bianco; Frederick W Alt
Conditional inactivation of p53 in mature B cells promotes generation of nongerminal center-derived B-cell lymphomas.
Proceedings of the National Academy of Sciences of the United States of America 2013;110(8):2934-9.
2013: Valentyn Oksenych; Bjoern Schwer; Shan Zha; Chunguang Guo; Vipul Kumar; Xiangyu Liu; Frederick W Alt
Functional redundancy between the XLF and DNA-PKcs DNA repair factors in V(D)J recombination and nonhomologous DNA end joining.
Proceedings of the National Academy of Sciences of the United States of America 2013;110(6):2234-9.
2012: John J Garber; Raif S Geha; Archana Kapoor; John M Leong; Anna Lyubimova; Michiko K Oyoshi; Tomoyuki Shibata; Frederick W Alt; Inés M Antón; Feng Chen; Fuminao Takeshima; Scott B Snapper
Enteropathogenic Escherichia coli and vaccinia virus do not require the family of WASP-interacting proteins for pathogen-induced actin assembly.
Infection and immunity 2012;80(12):4071-7.
2012: Duane R Wesemann; Xiaolong Zhou; Michael P Gallagher; Jennifer M Magee; Rohit A Panchakshari; Andrew J Portuguese; Frederick W Alt
Reprogramming IgH isotype-switched B cells to functional-grade induced pluripotent stem cells.
Proceedings of the National Academy of Sciences of the United States of America 2012;109(34):13745-50.
2012: Cristian Boboila; Hua Chai; Monica Gostissa; Mila Jankovic; Cheng-Sheng Lee; Peter J McKinnon; Michel C Nussenzweig; Valentyn Oksenych; Liz Marie Albertorio Saez; Jing H Wang; Shan Zha; Yu Zhang; Frederick W Alt; Bjoern Schwer
Robust chromosomal DNA repair via alternative end-joining in the absence of X-ray repair cross-complementing protein 1 (XRCC1).
Proceedings of the National Academy of Sciences of the United States of America 2012;109(7):2473-8.
2012: Valentyn Oksenych; Harin Patel; Bjoern Schwer; Arthur Su; Duane R Wesemann; Frederick W Alt; Erica Hansen; Vipul Kumar; Chunguang Guo
Functional redundancy between repair factor XLF and damage response mediator 53BP1 in V(D)J recombination and DNA repair.
Proceedings of the National Academy of Sciences of the United States of America 2012;109(7):2455-60.
2012: Cristian Boboila; Frederick W Alt; Bjoern Schwer
Classical and alternative end-joining pathways for repair of lymphocyte-specific and general DNA double-strand breaks.
Advances in immunology 2012;116():1-49.
2011: Matthew David Hirschey; Enxuan Jing; C Ronald Kahn; Sanjay Kakar; Johanna Kuusisto; Markku Laakso; Maggie M Lam; Michael J Muehlbauer; Christopher B Newgard; Bjoern Schwer; Tadahiro Shimazu; Alena Stančáková; Robert D Stevens; Frederick W Alt; Bradley Aouizerat; Nathan M Bass; Amy M Collins; Robert V Farese; Eric Goetzman; Carrie A Grueter; Eric Verdin
SIRT3 deficiency and mitochondrial protein hyperacetylation accelerate the development of the metabolic syndrome.
Molecular cell 2011;44(2):177-90.
2011: Alejandro Gutierrez; Linda Holmfeldt; Stephen P Hunger; Alex Kentsis; Frederick W Alt; Shann-Ching Chen; Lynda Chin; Suzanne E Dahlberg; James R Downing; Charles G Mullighan; Donna Neuberg; Alexei Protopopov; Stephen E Sallan; Takaomi Sanda; Lewis B Silverman; Stuart S Winter; Shan Zha; Jianhua Zhang; A Thomas Look
The BCL11B tumor suppressor is mutated across the major molecular subtypes of T-cell acute lymphoblastic leukemia.
Blood 2011;118(15):4169-73.
2011: Chunguang Guo; Erica Hansen; Suvi Jain; Cornelis Murre; Darienne Myers; Harin Patel; Nicholas Richards; Mark S Schlissel; Christian Vettermann; Hye Suk Yoon; Jamie G Bates; Claudia Bossen; Meinrad Busslinger; Hwei-Ling Cheng; Orion Despo; Anja Ebert; Andrew Franklin; Michael Gallagher; Cosmas C Giallourakis; Frederick W Alt
CTCF-binding elements mediate control of V(D)J recombination.
Nature 2011;477(7365):424-30.
2011: Wataru Ise; Masako Kohyama; Barbara U Schraml; Tingting Zhang; Bjoern Schwer; Uttiya Basu; Frederick W Alt; Jun Tang; Eugene M Oltz; Theresa L Murphy; Kenneth M Murphy
The transcription factor BATF controls the global regulators of class-switch recombination in both B cells and T cells.
Nature immunology 2011;12(6):536-43.
2011: Chunguang Guo; Frederick W Alt; Cosmas Giallourakis
PAIRing for distal Igh locus V(D)J recombination.
Immunity 2011;34(2):139-41.
2011: Michael Green; Stefano Monti; Riccardo Dalla-Favera; Laura Pasqualucci; Nicole C Walsh; Marc Schmidt-Supprian; Jeffery L Kutok; Scott Rodig; Donna S Neuberg; Klaus Rajewsky; Todd R Golub; Frederick W Alt; Margaret A Shipp; John P Manis
Signatures of murine B-cell development implicate Yy1 as a regulator of the germinal center-specific program.
Proceedings of the National Academy of Sciences of the United States of America 2011;108(7):2873-8.
2011: Jennifer Eccleston; Catherine Yan; Karen Yuan; Frederick W Alt; Erik Selsing
Mismatch repair proteins MSH2, MLH1, and EXO1 are important for class-switch recombination events occurring in B cells that lack nonhomologous end joining.
Journal of immunology (Baltimore, Md. : 1950) 2011;186(4):2336-43.
2011: Uttiya Basu; Fei-Long Meng; Celia Keim; Veronika Grinstein; Evangelos Pefanis; Jennifer Eccleston; Tingting Zhang; Darienne Myers; Caitlyn R Wasserman; Duane R Wesemann; Kurt Januszyk; Richard I Gregory; Haiteng Deng; Christopher D Lima; Frederick W Alt
The RNA exosome targets the AID cytidine deaminase to both strands of transcribed duplex DNA substrates.
Cell 2011;144(3):353-63.
2011: Shan Zha; Wenxia Jiang; Yuko Fujiwara; Harin Patel; Peter H Goff; James W Brush; Richard L Dubois; Frederick W Alt
Ataxia telangiectasia-mutated protein and DNA-dependent protein kinase have complementary V(D)J recombination functions.
Proceedings of the National Academy of Sciences of the United States of America 2011;108(5):2028-33.
2011: Shan Zha; Chunguang Guo; Cristian Boboila; Valentyn Oksenych; Hwei-Ling Cheng; Y Zhang; Duane R Wesemann; Grace Yuen; Harin Patel; Peter H Goff; Richard L Dubois; Frederick W Alt
ATM damage response and XLF repair factor are functionally redundant in joining DNA breaks.
Nature 2011;469(7329):250-4.
2010: Cosmas Giallourakis; Andrew Franklin; Chunguang Guo; Hwei-Ling Cheng; Hye Suk Yoon; Michael Gallagher; Thomas Perlot; Milena Andzelm; Andrew J Murphy; Lynn E Macdonald; George D Yancopoulos; Frederick W Alt
Elements between the IgH variable (V) and diversity (D) clusters influence antisense transcription and lineage-specific V(D)J recombination.
Proceedings of the National Academy of Sciences of the United States of America 2010;107(51):22207-12.
2010: Bjoern Schwer; Bjoern Schumacher; David Lombard; Cuiying Xiao; Martin V Kurtev; Jun Gao; Jennifer I Schneider; Hua Chai; Roderick T Bronson; Li-Huei Tsai; Chu-Xia Deng; Frederick W Alt
Neural sirtuin 6 (Sirt6) ablation attenuates somatic growth and causes obesity.
Proceedings of the National Academy of Sciences of the United States of America 2010;107(50):21790-4.
2010: Tadahiro Shimazu; Matthew David Hirschey; Lan Hua; Kristin E Dittenhafer-Reed; Bjoern Schwer; David Lombard; Yu Li; Jakob Bunkenborg; Frederick W Alt; John M Denu; Matthew P Jacobson; Eric Verdin
SIRT3 deacetylates mitochondrial 3-hydroxy-3-methylglutaryl CoA synthase 2 and regulates ketone body production.
Cell metabolism 2010;12(6):654-61.
2010: Shan Zha; Craig H Bassing; Takaomi Sanda; James W Brush; Harin Patel; Peter H Goff; Michael M Murphy; Suprawee Tepsuporn; Richard A Gatti; A Thomas Look; Frederick W Alt
ATM-deficient thymic lymphoma is associated with aberrant tcrd rearrangement and gene amplification.
The Journal of experimental medicine 2010;207(7):1369-80.
2010: Lisa S Westerberg; Parool Meelu; Marisa Baptista; Michelle A Eston; David A Adamovich; Vinícius Cotta-de-Almeida; Brian Seed; Michael K Rosen; Peter Vandenberghe; Adrian J Thrasher; Christoph Klein; Frederick W Alt; Scott B Snapper
Activating WASP mutations associated with X-linked neutropenia result in enhanced actin polymerization, altered cytoskeletal responses, and genomic instability in lymphocytes.
The Journal of experimental medicine 2010;207(6):1145-52.
2010: Cristian Boboila; Mila Jankovic; Catherine T Yan; Jing H Wang; Duane R Wesemann; Tingting Zhang; Alex Fazeli; Lauren Feldman; Andre Nussenzweig; Michel Nussenzweig; Frederick W Alt
Alternative end-joining catalyzes robust IgH locus deletions and translocations in the combined absence of ligase 4 and Ku70.
Proceedings of the National Academy of Sciences of the United States of America 2010;107(7):3034-9.
2010: Tingting Zhang; Andrew Franklin; Cristian Boboila; Amy McQuay; Michael P Gallagher; John P Manis; Ahmed Amine Khamlichi; Frederick W Alt
Downstream class switching leads to IgE antibody production by B lymphocytes lacking IgM switch regions.
Proceedings of the National Academy of Sciences of the United States of America 2010;107(7):3040-5.
2010: Francesca Rucci; Luigi D Notarangelo; Alex Fazeli; Laura Patrizi; Thomas Hickernell; Tiziana Paganini; Kristen M Coakley; Cynthia Detre; Marton Keszei; Jolan E Walter; Lauren Feldman; Hwei-Ling Cheng; Pietro Luigi Poliani; Jing H Wang; Barbara B Balter; Mike Recher; Emma-Maria Andersson; Shan Zha; Silvia Giliani; Cox Terhorst; Frederick W Alt; Catherine T Yan
Homozygous DNA ligase IV R278H mutation in mice leads to leaky SCID and represents a model for human LIG4 syndrome.
Proceedings of the National Academy of Sciences of the United States of America 2010;107(7):3024-9.
2010: Cristian Boboila; Catherine Yan; Duane R Wesemann; Mila Jankovic; Jing H Wang; John P Manis; Andre Nussenzweig; Michel Nussenzweig; Frederick W Alt
Alternative end-joining catalyzes class switch recombination in the absence of both Ku70 and DNA ligase 4.
The Journal of experimental medicine 2010;207(2):417-27.
2010: Thomas Perlot; Inka Pawlitzky; John P Manis; Ali A Zarrin; Peter H Brodeur; Frederick W Alt
Analysis of mice lacking DNaseI hypersensitive sites at the 5' end of the IgH locus.
PloS one 2010;5(11):e13992.
2010: Yu Zhang; Monica Gostissa; Dominic G Hildebrand; Michael S Becker; Cristian Boboila; Roberto Chiarle; Susanna Lewis; Frederick W Alt
The role of mechanistic factors in promoting chromosomal translocations found in lymphoid and other cancers.
Advances in immunology 2010;106():93-133.
2009: Monica Gostissa; Catherine T Yan; Julia M Bianco; Michel Cogné; Eric Pinaud; Frederick W Alt
Long-range oncogenic activation of Igh-c-myc translocations by the Igh 3' regulatory region.
Nature 2009;462(7274):803-7.
2009: Yu-Nee Lee; Frederick W Alt; Julia Reyes; Megan Gleason; Ali A Zarrin; David Jung
Differential utilization of T cell receptor TCR alpha/TCR delta locus variable region gene segments is mediated by accessibility.
Proceedings of the National Academy of Sciences of the United States of America 2009;106(41):17487-92.
2009: Bjoern Schwer; Mark Eckersdorff; Yu Li; Jeffrey C Silva; Damian Fermin; Martin V Kurtev; Cosmas Giallourakis; Michael J Comb; Frederick W Alt; David Lombard
Calorie restriction alters mitochondrial protein acetylation.
Aging cell 2009;8(5):604-6.
2009: Shan Zha; Cristian Boboila; Frederick W Alt
Mre11: roles in DNA repair beyond homologous recombination.
Nature structural & molecular biology 2009;16(8):798-800.
2009: Jing H Wang; Monica Gostissa; Catherine T Yan; Peter Goff; Thomas Hickernell; Erica Hansen; Simone Difilippantonio; Duane R Wesemann; Ali A Zarrin; Klaus Rajewsky; André Nussenzweig; Frederick W Alt
Mechanisms promoting translocations in editing and switching peripheral B cells.
Nature 2009;460(7252):231-6.
2009: Uttiya Basu; Andrew Franklin; Bjoern Schwer; Hwei-Ling Cheng; Jayanta Chaudhuri; Frederick W Alt
Regulation of activation-induced cytidine deaminase DNA deamination activity in B-cells by Ser38 phosphorylation.
Biochemical Society transactions 2009;37(Pt 3):561-8.
2009: William Giblin; Monalisa Chatterji; Gerwin Westfield; Tehmina Masud; Brian Theisen; Hwei-Ling Cheng; Jeffrey DeVido; Frederick W Alt; David O Ferguson; David G Schatz; JoAnn Sekiguchi
Leaky severe combined immunodeficiency and aberrant DNA rearrangements due to a hypomorphic RAG1 mutation.
Blood 2009;113(13):2965-75.
2009: Uttiya Basu; Andrew Franklin; Frederick W Alt
Post-translational regulation of activation-induced cytidine deaminase.
Philosophical transactions of the Royal Society of London. Series B, Biological sciences 2009;364(1517):667-73.
2009: Hwei-Ling Cheng; Bao Q Vuong; Uttiya Basu; Andrew Franklin; Bjoern Schwer; Jillian Astarita; Ryan T Phan; Abhishek Datta; John P Manis; Frederick W Alt; Jayanta Chaudhuri
Integrity of the AID serine-38 phosphorylation site is critical for class switch recombination and somatic hypermutation in mice.
Proceedings of the National Academy of Sciences of the United States of America 2009;106(8):2717-22.
2009: Monica Gostissa; Sheila Ranganath; Julia M Bianco; Frederick W Alt
Chromosomal location targets different MYC family gene members for oncogenic translocations.
Proceedings of the National Academy of Sciences of the United States of America 2009;106(7):2265-70.
2009: Frédéric Van Gool; Mara Gallí; Cyril Gueydan; Véronique Kruys; Pierre-Paul Prevot; Antonio Bedalov; Raul Mostoslavsky; Frederick W Alt; Thibaut De Smedt; Oberdan Leo
Intracellular NAD levels regulate tumor necrosis factor protein synthesis in a sirtuin-dependent manner.
Nature medicine 2009;15(2):206-10.
2008: Philipp Oberdoerffer; Shaday Michan; Michael McVay; Raul Mostoslavsky; James Vann; Sang-Kyu Park; Andrea Hartlerode; Judith Stegmuller; Angela Hafner; Patrick Loerch; Sarah M Wright; Kevin D Mills; Azad Bonni; Bruce A Yankner; Ralph Scully; Tomas A Prolla; Frederick W Alt; David A Sinclair
SIRT1 redistribution on chromatin promotes genomic stability but alters gene expression during aging.
Cell 2008;135(5):907-18.
2008: Uttiya Basu; Yabin Wang; Frederick W Alt
Evolution of phosphorylation-dependent regulation of activation-induced cytidine deaminase.
Molecular cell 2008;32(2):285-91.
2008: Gang Li; Frederick W Alt; Hwei-Ling Cheng; James W Brush; Peter H Goff; Michael M Murphy; Sonia Franco; Yu Zhang; Shan Zha
Lymphocyte-specific compensation for XLF/cernunnos end-joining functions in V(D)J recombination.
Molecular cell 2008;31(5):631-40.
2008: Gad Asher; David Gatfield; Markus Stratmann; Hans Reinke; Charna Dibner; Florian Kreppel; Raul Mostoslavsky; Frederick W Alt; Ueli Schibler
SIRT1 regulates circadian clock gene expression through PER2 deacetylation.
Cell 2008;134(2):317-28.
2008: Shan Zha; JoAnn Sekiguchi; James W Brush; Craig H Bassing; Frederick W Alt
Complementary functions of ATM and H2AX in development and suppression of genomic instability.
Proceedings of the National Academy of Sciences of the United States of America 2008;105(27):9302-6.
2008: Ali A Zarrin; Peter H Goff; Kate Senger; Frederick W Alt
Sgamma3 switch sequences function in place of endogenous Sgamma1 to mediate antibody class switching.
The Journal of experimental medicine 2008;205(7):1567-72.
2008: Danica Chen; Joanne Bruno; Erin Easlon; Su-Ju Lin; Hwei-Ling Cheng; Frederick W Alt; Leonard Guarente
Tissue-specific regulation of SIRT1 by calorie restriction.
Genes & development 2008;22(13):1753-7.
2008: Carl R Walkley; Rameez Qudsi; Vijay G Sankaran; Jennifer A. Perry; Monica Gostissa; Sanford I Roth; Stephen J Rodda; Erin Snay; Patricia Dunning; Frederic H Fahey; Frederick W Alt; Andrew P McMahon; Stuart H Orkin
Conditional mouse osteosarcoma, dependent on p53 loss and potentiated by loss of Rb, mimics the human disease.
Genes & development 2008;22(12):1662-76.
2008: Sonia Franco; Michael M Murphy; Gang Li; Tiffany Borjeson; Cristian Boboila; Frederick W Alt
DNA-PKcs and Artemis function in the end-joining phase of immunoglobulin heavy chain class switch recombination.
The Journal of experimental medicine 2008;205(3):557-64.
2008: Thomas Perlot; Gang Li; Frederick W Alt
Antisense transcripts from immunoglobulin heavy-chain locus V(D)J and switch regions.
Proceedings of the National Academy of Sciences of the United States of America 2008;105(10):3843-8.
2008: In Hye Lee; Liu Cao; Raul Mostoslavsky; David Lombard; Jie Liu; Nicholas E Bruns; Maria Tsokos; Frederick W Alt; TOREN FINKEL
A role for the NAD-dependent deacetylase Sirt1 in the regulation of autophagy.
Proceedings of the National Academy of Sciences of the United States of America 2008;105(9):3374-9.
2008: Yu Zhang; Sohee Kwon; Teppei Yamaguchi; fabien cubizolles; Sophie Rousseaux; Michaela Kneissel; Chun Cao; Na Li; Hwei-Ling Cheng; Katrin Chua; David Lombard; Adam Mizeracki; Gabriele Matthias; Frederick W Alt; Saadi Khochbin; Patrick Matthias
Mice lacking histone deacetylase 6 have hyperacetylated tubulin but are viable and develop normally.
Molecular and cellular biology 2008;28(5):1688-701.
2008: Sheila Ranganath; Andrea C Carpenter; Megan Gleason; Albert C Shaw; Craig H Bassing; Frederick W Alt
Productive coupling of accessible Vbeta14 segments and DJbeta complexes determines the frequency of Vbeta14 rearrangement.
Journal of immunology (Baltimore, Md. : 1950) 2008;180(4):2339-46.
2008: David Lombard; Bjoern Schwer; Frederick W Alt; Raul Mostoslavsky
SIRT6 in DNA repair, metabolism and ageing.
Journal of internal medicine 2008;263(2):128-41.
2008: Kunihiko Takeyama; S Monti; John P Manis; P Dal Cin; Gad Getz; Rameen Beroukhim; Shilpee Dutt; Jon C Aster; Frederick W Alt; Todd R Golub; Margaret A Shipp
Integrative analysis reveals 53BP1 copy loss and decreased expression in a subset of human diffuse large B-cell lymphomas.
Oncogene 2008;27(3):318-22.
2008: Thomas Perlot; Frederick W Alt
Cis-regulatory elements and epigenetic changes control genomic rearrangements of the IgH locus.
Advances in immunology 2008;99():1-32.
2008: Haifa Jabara; Jayanta Chaudhuri; Shilpee Dutt; Fatma Dedeoglu; Yu Weng; Michael M Murphy; Sonia Franco; Frederick W Alt; John P Manis; Raif S Geha
B-cell receptor cross-linking delays activation-induced cytidine deaminase induction and inhibits class-switch recombination to IgE.
The Journal of allergy and clinical immunology 2008;121(1):191-196.e2.
2007: Anyong Xie; Andrea Hartlerode; Manuel Stucki; Shobu Odate; Nadine Puget; Amy Kwok; Ganesh Nagaraju; Catherine Yan; Frederick W Alt; Junjie Chen; Stephen P Jackson; Ralph Scully
Distinct roles of chromatin-associated proteins MDC1 and 53BP1 in mammalian double-strand break repair.
Molecular cell 2007;28(6):1045-57.
2007: David Lombard; Frederick W Alt; Hwei-Ling Cheng; Jakob Bunkenborg; Ryan S Streeper; Raul Mostoslavsky; Jennifer Kim; George D Yancopoulos; David M Valenzuela; Andrew Murphy; Yinhua Yang; Yaohui Chen; Matthew David Hirschey; Roderick T Bronson; Marcia Haigis; Leonard Guarente; Robert V Farese; Sherman Weissman; Eric Verdin; Bjoern Schwer
Mammalian Sir2 homolog SIRT3 regulates global mitochondrial lysine acetylation.
Molecular and cellular biology 2007;27(24):8807-14.
2007: Robert Wuerffel; Lili Wang; Fernando Grigera; John P Manis; Erik Selsing; Thomas Perlot; Frederick W Alt; Michel Cogne; Eric Pinaud; Amy L Kenter
S-S synapsis during class switch recombination is promoted by distantly located transcriptional elements and activation-induced deaminase.
Immunity 2007;27(5):711-22.
2007: Frederick W Alt
From gene amplification to V(D)J recombination and back: a personal account of my early years in B cell biology.
European journal of immunology 2007;37 Suppl 1():S138-47.
2007: Catherine T Yan; Cristian Boboila; Ellen Kris Souza; Sonia Franco; Thomas R Hickernell; Michael Murphy; Sunil Gumaste; Mark Geyer; Ali A Zarrin; John P Manis; Klaus Rajewsky; Frederick W Alt
IgH class switching and translocations use a robust non-classical end-joining pathway.
Nature 2007;449(7161):478-82.
2007: Shan Zha; Frederick W Alt; Hwei-Ling Cheng; James W Brush; Gang Li
Defective DNA repair and increased genomic instability in Cernunnos-XLF-deficient murine ES cells.
Proceedings of the National Academy of Sciences of the United States of America 2007;104(11):4518-23.
2007: Cherry Wu; Sheila Ranganath; Megan Gleason; Barbara B Woodman; Tiffany M Borjeson; Frederick W Alt; Craig H Bassing
Restriction of endogenous T cell antigen receptor beta rearrangements to Vbeta14 through selective recombination signal sequence modifications.
Proceedings of the National Academy of Sciences of the United States of America 2007;104(10):4002-7.
2007: Ali A Zarrin; Catherine Del Vecchio; Eva Tseng; Megan Gleason; Payam Zarin; Ming Tian; Frederick W Alt
Antibody class switching mediated by yeast endonuclease-generated DNA breaks.
Science (New York, N.Y.) 2007;315(5810):377-81.
2007: Jayanta Chaudhuri; Uttiya Basu; Ali A Zarrin; Catherine Yan; Sonia Franco; Thomas Perlot; Bao Vuong; Jing Wang; Ryan T Phan; Abhishek Datta; John P Manis; Frederick W Alt
Evolution of the immunoglobulin heavy chain class switch recombination mechanism.
Advances in immunology 2007;94():157-214.
2007: Uttiya Basu; Jayanta Chaudhuri; Ryan T Phan; Abhishek Datta; Frederick W Alt
Regulation of activation induced deaminase via phosphorylation.
Advances in experimental medicine and biology 2007;596():129-37.
2006: Marcia Haigis; Raul Mostoslavsky; Kevin Haigis; Kamau Fahie; Danos C Christodoulou; Andrew J Murphy; David M Valenzuela; George D Yancopoulos; Margaret L Karow; Gil Blander; Cynthia Wolberger; Tomas A Prolla; Richard Weindruch; Frederick W Alt; Leonard Guarente
SIRT4 inhibits glutamate dehydrogenase and opposes the effects of calorie restriction in pancreatic beta cells.
Cell 2006;126(5):941-54.
2006: Sonia Franco; Frederick W Alt; John P Manis
Pathways that suppress programmed DNA breaks from progressing to chromosomal breaks and translocations.
DNA repair 2006;5(9-10):1030-41.
2006: Catherine T Yan; Dhruv Kaushal; Michael Murphy; Yu Zhang; Abhishek Datta; Changzhong Chen; Brianna Monroe; Gustavo Mostoslavsky; Kristen Coakley; Yijie Gao; Kevin D Mills; Alex P Fazeli; Suprawee Tepsuporn; Giles Hall; Richard Mulligan; Edward Fox; Roderick Bronson; Umberto De Girolami; Charles Lee; Frederick W Alt
XRCC4 suppresses medulloblastomas with recurrent translocations in p53-deficient mice.
Proceedings of the National Academy of Sciences of the United States of America 2006;103(19):7378-83.
2006: Simonne Longerich; Uttiya Basu; Frederick W Alt; Ursula Storb
AID in somatic hypermutation and class switch recombination.
Current opinion in immunology 2006;18(2):164-74.
2006: Julio Cesar Morales; Sonia Franco; Michael M Murphy; Craig H Bassing; Kevin D Mills; Melissa M Adams; Nicole C Walsh; John P Manis; George Z Rassidakis; Frederick W Alt; Phillip B Carpenter
53BP1 and p53 synergize to suppress genomic instability and lymphomagenesis.
Proceedings of the National Academy of Sciences of the United States of America 2006;103(9):3310-5.
2006: Sonia Franco; Monica Gostissa; Shan Zha; David Lombard; Michael M Murphy; Ali A Zarrin; Catherine Yan; Suprawee Tepsuporn; Julio Cesar Morales; Melissa M Adams; Zhenkun Lou; Craig H Bassing; John P Manis; Junjie Chen; Phillip B Carpenter; Frederick W Alt
H2AX prevents DNA breaks from progressing to chromosome breaks and translocations.
Molecular cell 2006;21(2):201-14.
2006: Zhenkun Lou; Katherine Minter-Dykhouse; Sonia Franco; Monica Gostissa; Melissa A Rivera; Arkady Celeste; John P Manis; Jan M A van Deursen; André Nussenzweig; Tanya T Paull; Frederick W Alt; Junjie Chen
MDC1 maintains genomic stability by participating in the amplification of ATM-dependent DNA damage signals.
Molecular cell 2006;21(2):187-200.
2006: Jennifer O'Neil; Jennifer Calvo; Keith McKenna; Veena Krishnamoorthy; Jon C Aster; Craig H Bassing; Frederick W Alt; Michelle A Kelliher; A Thomas Look
Activating Notch1 mutations in mouse models of T-ALL.
Blood 2006;107(2):781-5.
2006: David Jung; Cosmas Giallourakis; Raul Mostoslavsky; Frederick W Alt
Mechanism and control of V(D)J recombination at the immunoglobulin heavy chain locus.
Annual review of immunology 2006;24():541-70.
2005: Uttiya Basu; Jayanta Chaudhuri; Craig Alpert; Shilpee Dutt; Sheila Ranganath; Gang Li; Jason Schrum; John P Manis; Frederick W Alt
The AID antibody diversification enzyme is regulated by protein kinase A phosphorylation.
Nature 2005;438(7067):508-11.
2005: Thomas Perlot; Frederick W Alt; Craig H Bassing; Heikyung Suh; Eric Pinaud
Elucidation of IgH intronic enhancer functions via germ-line deletion.
Proceedings of the National Academy of Sciences of the United States of America 2005;102(40):14362-7.
2005: Katrin F Chua; Raul Mostoslavsky; David Lombard; Wendy W Pang; Shin'ichi Saito; Sonia Franco; Dhruv Kaushal; Hwei-Ling Cheng; Miriam R Fischer; Nicole Stokes; Michael M Murphy; Ettore Appella; Frederick W Alt
Mammalian SIRT1 limits replicative life span in response to chronic genotoxic stress.
Cell metabolism 2005;2(1):67-76.
2005: David Lombard; Katrin F Chua; Raul Mostoslavsky; Sonia Franco; Monica Gostissa; Frederick W Alt
DNA repair, genome stability, and aging.
Cell 2005;120(4):497-512.
2005: Sean Rooney; Frederick W Alt; JoAnn Sekiguchi; John P Manis
Artemis-independent functions of DNA-dependent protein kinase in Ig heavy chain class switch recombination and development.
Proceedings of the National Academy of Sciences of the United States of America 2005;102(7):2471-5.
2005: Ali A Zarrin; Ming Tian; Jing Wang; Tiffany Borjeson; Frederick W Alt
Influence of switch region length on immunoglobulin class switch recombination.
Proceedings of the National Academy of Sciences of the United States of America 2005;102(7):2466-70.
2005: Darryll D Dudley; Jayanta Chaudhuri; Craig H Bassing; Frederick W Alt
Mechanism and control of V(D)J recombination versus class switch recombination: similarities and differences.
Advances in immunology 2005;86():43-112.
2005: Jian Kang; David O Ferguson; Hoseok Song; Craig H Bassing; Mark Eckersdorff; Frederick W Alt; Yang Xu
Functional interaction of H2AX, NBS1, and p53 in ATM-dependent DNA damage responses and tumor suppression.
Molecular and cellular biology 2005;25(2):661-70.
2004: Anyong Xie; Nadine Puget; Inbo Shim; Shobu Odate; Ingeborga Jarzyna; Craig H Bassing; Frederick W Alt; Ralph Scully
Control of sister chromatid recombination by histone H2AX.
Molecular cell 2004;16(6):1017-25.
2004: Ali A Zarrin; Frederick W Alt; Jayanta Chaudhuri; Nicole Stokes; Dhruv Kaushal; Louis Du Pasquier; Ming Tian
An evolutionarily conserved target motif for immunoglobulin class-switch recombination.
Nature immunology 2004;5(12):1275-81.
2004: K Mark Ansel; Rebecca J Greenwald; Suneet Agarwal; Craig H Bassing; Silvia Monticelli; Jeneen Interlandi; Ivana M Djuretic; Dong U Lee; Arlene H Sharpe; Frederick W Alt; Anjana Rao
Deletion of a conserved Il4 silencer impairs T helper type 1-mediated immunity.
Nature immunology 2004;5(12):1251-9.
2004: Raul Mostoslavsky; Frederick W Alt; Klaus Rajewsky
The lingering enigma of the allelic exclusion mechanism.
Cell 2004;118(5):539-44.
2004: Jayanta Chaudhuri; Chan Khuong; Frederick W Alt
Replication protein A interacts with AID to promote deamination of somatic hypermutation targets.
Nature 2004;430(7003):992-8.
2004: Sean Rooney; Jayanta Chaudhuri; Frederick W Alt
The role of the non-homologous end-joining pathway in lymphocyte development.
Immunological reviews 2004;200():115-31.
2004: Makoto Senoo; John P Manis; Frederick W Alt; Frank McKeon
p63 and p73 are not required for the development and p53-dependent apoptosis of T cells.
Cancer cell 2004;6(1):85-9.
2004: Chrystelle Couëdel; Kevin D Mills; marco barchi; Lingbo Shen; Adam B Olshen; Roger D Johnson; André Nussenzweig; Jeroen Essers; Roland Kanaar; Gloria C Li; Frederick W Alt; Maria Jasin
Collaboration of homologous recombination and nonhomologous end-joining factors for the survival and integrity of mice and cells.
Genes & development 2004;18(11):1293-304.
2004: Kevin D Mills; David O Ferguson; Jeroen Essers; Mark Eckersdorff; Roland Kanaar; Frederick W Alt
Rad54 and DNA Ligase IV cooperate to maintain mammalian chromatid stability.
Genes & development 2004;18(11):1283-92.
2004: Cosmas Giallourakis; Frederick W Alt; Craig H Bassing
V(D)J recombinational accessibility-heading in the opposite direction?
Nature immunology 2004;5(6):561-2.
2004: Raul Mostoslavsky; Frederick W Alt
Receptor revision in T cells: an open question?
Trends in immunology 2004;25(6):276-9.
2004: John P Manis; Julio Cesar Morales; Zhenfang Xia; Jeffery L Kutok; Frederick W Alt; Phillip B Carpenter
53BP1 links DNA damage-response pathways to immunoglobulin heavy chain class-switch recombination.
Nature immunology 2004;5(5):481-7.
2004: Anne Brunet; Lora B Sweeney; J Fitzhugh Sturgill; Katrin F Chua; Paul L Greer; Yingxi Lin; Hien Tran; Sarah E Ross; Raul Mostoslavsky; Haim Y Cohen; Linda S Hu; Hwei-Ling Cheng; Mark P Jedrychowski; Steven P Gygi; David A Sinclair; Frederick W Alt; Michael E Greenberg
Stress-dependent regulation of FOXO transcription factors by the SIRT1 deacetylase.
Science (New York, N.Y.) 2004;303(5666):2011-5.
2004: Sean Rooney; JoAnn Sekiguchi; Scott Whitlow; Mark Eckersdorff; John P Manis; Charles Lee; David O Ferguson; Frederick W Alt
Artemis and p53 cooperate to suppress oncogenic N-myc amplification in progenitor B cells.
Proceedings of the National Academy of Sciences of the United States of America 2004;101(8):2410-5.
2004: David Jung; Frederick W Alt
Unraveling V(D)J recombination; insights into gene regulation.
Cell 2004;116(2):299-311.
2004: Sadiqur R Talukder; Darryll D Dudley; Frederick W Alt; Yousuke Takahama; Yoshiko Akamatsu
Increased frequency of aberrant V(D)J recombination products in core RAG-expressing mice.
Nucleic acids research 2004;32(15):4539-49.
2003: Jan-Willem F Theunissen; Mark I Kaplan; Patricia A Hunt; Bret R Williams; David O Ferguson; Frederick W Alt; John H J Petrini
Checkpoint failure and chromosomal instability without lymphomagenesis in Mre11(ATLD1/ATLD1) mice.
Molecular cell 2003;12(6):1511-23.
2003: Vadim Pivniouk; Scott B Snapper; Alexander Kettner; Harri Alenius; Dhafer Laouini; Hervé Falet; John Hartwig; Frederick W Alt; Raif S Geha
Impaired signaling via the high-affinity IgE receptor in Wiskott-Aldrich syndrome protein-deficient mast cells.
International immunology 2003;15(12):1431-40.
2003: Keiko Fujikawa; Ana V Miletic; Frederick W Alt; Roberta Faccio; Tracie Brown; Jeremy Hoog; Jessica Fredericks; Shinzo Nishi; Shirly Mildiner; Sheri L Moores; Joan S Brugge; Fred S Rosen; Wojciech Swat
Vav1/2/3-null mice define an essential role for Vav family proteins in lymphocyte development and activation but a differential requirement in MAPK signaling in T and B cells.
The Journal of experimental medicine 2003;198(10):1595-608.
2003: Darryll D Dudley; JoAnn Sekiguchi; Chengming Zhu; Moshe J Sadofsky; Scott Whitlow; Jeffrey DeVido; Robert J Monroe; Craig H Bassing; Frederick W Alt
Impaired V(D)J recombination and lymphocyte development in core RAG1-expressing mice.
The Journal of experimental medicine 2003;198(9):1439-50.
2003: Hwei-Ling Cheng; Raul Mostoslavsky; Shin'ichi Saito; John P Manis; Yansong Gu; Parin Patel; Roderick Bronson; Ettore Appella; Frederick W Alt; Katrin F Chua
Developmental defects and p53 hyperacetylation in Sir2 homolog (SIRT1)-deficient mice.
Proceedings of the National Academy of Sciences of the United States of America 2003;100(19):10794-9.
2003: Craig H Bassing; Heikyung Suh; David O Ferguson; Katrin F Chua; John P Manis; Mark Eckersdorff; Megan Gleason; Rodrick Bronson; Charles Lee; Frederick W Alt
Histone H2AX: a dosage-dependent suppressor of oncogenic translocations and tumors.
Cell 2003;114(3):359-70.
2003: Kevin D Mills; David O Ferguson; Frederick W Alt
The role of DNA breaks in genomic instability and tumorigenesis.
Immunological reviews 2003;194():77-95.
2003: John P Manis; Frederick W Alt
Novel antibody switching defects in human patients.
The Journal of clinical investigation 2003;112(1):19-22.
2003: Raul Mostoslavsky; Frederick W Alt; Craig H Bassing
Chromatin dynamics and locus accessibility in the immune system.
Nature immunology 2003;4(7):603-6.
2003: Reiko Shinkura; Ming Tian; Michele Smith; Katrin Chua; Yuko Fujiwara; Frederick W Alt
The influence of transcriptional orientation on endogenous switch region function.
Nature immunology 2003;4(5):435-41.
2003: Jayanta Chaudhuri; Ming Tian; Chan Khuong; Katrin Chua; Eric Pinaud; Frederick W Alt
Transcription-targeted DNA deamination by the AID antibody diversification enzyme.
Nature 2003;422(6933):726-30.
2003: Christoph Klein; Deanna Nguyen; Ching-Hui Liu; Atsushi Mizoguchi; Atul K Bhan; Hiroaki Miki; Tadaomi Takenawa; Fred S Rosen; Frederick W Alt; Richard C Mulligan; Scott B Snapper
Gene therapy for Wiskott-Aldrich syndrome: rescue of T-cell signaling and amelioration of colitis upon transplantation of retrovirally transduced hematopoietic stem cells in mice.
Blood 2003;101(6):2159-66.
2003: Craig H Bassing; Robert E Tillman; Barbara B Woodman; David Canty; Robert J Monroe; Barry P Sleckman; Frederick W Alt
T cell receptor (TCR) alpha/delta locus enhancer identity and position are critical for the assembly of TCR delta and alpha variable region genes.
Proceedings of the National Academy of Sciences of the United States of America 2003;100(5):2598-603.
2003: Sean Rooney; Frederick W Alt; David Lombard; Scott Whitlow; Mark Eckersdorff; James Fleming; Sebastian D Fugmann; David O Ferguson; David G Schatz; JoAnn Sekiguchi
Defective DNA repair and increased genomic instability in Artemis-deficient murine cells.
The Journal of experimental medicine 2003;197(5):553-65.
2003: Kwok-Kin Wong; richard s maser; Robert M Bachoo; Jayant Menon; Daniel R Carrasco; Yansong Gu; Frederick W Alt; Ronald A DePinho
Telomere dysfunction and Atm deficiency compromises organ homeostasis and accelerates ageing.
Nature 2003;421(6923):643-8.
2003: Yoshiko Akamatsu; Robert J Monroe; Darryll D Dudley; Sheryl K Elkin; Frank Gartner; Sadiqur R Talukder; Yousuke Takahama; Frederick W Alt; Craig H Bassing; Marjorie A Oettinger
Deletion of the RAG2 C terminus leads to impaired lymphoid development in mice.
Proceedings of the National Academy of Sciences of the United States of America 2003;100(3):1209-14.
2003: Wojciech Swat; Ramnik Xavier; Atsushi Mizoguchi; Emiko Mizoguchi; Jessica Fredericks; Keiko Fujikawa; Atul K Bhan; Frederick W Alt
Essential role for Vav1 in activation, but not development, of gammadelta T cells.
International immunology 2003;15(2):215-21.
2003: Sandra S Zinkel; Christy C Ong; David O Ferguson; Hiromi Iwasaki; Koichi Akashi; Roderick T Bronson; Jeffery L Kutok; Frederick W Alt; Stanley J Korsmeyer
Proapoptotic BID is required for myeloid homeostasis and tumor suppression.
Genes & development 2003;17(2):229-39.
2003: John P Manis; Jennifer S Michaelson; Barbara K Birshtein; Frederick W Alt
Elucidation of a downstream boundary of the 3' IgH regulatory region.
Molecular immunology 2003;39(12):753-60.
2003: Cherry Wu; Craig H Bassing; David Jung; Barbara B Woodman; Dan Foy; Frederick W Alt
Dramatically increased rearrangement and peripheral representation of Vbeta14 driven by the 3'Dbeta1 recombination signal sequence.
Immunity 2003;18(1):75-85.
2003: David Jung; Craig H Bassing; Sebastian D Fugmann; Hwei-Ling Cheng; David G Schatz; Frederick W Alt
Extrachromosomal recombination substrates recapitulate beyond 12/23 restricted VDJ recombination in nonlymphoid cells.
Immunity 2003;18(1):65-74.
2002: Sean Rooney; JoAnn Sekiguchi; Chengming Zhu; Hwei-Ling Cheng; John P Manis; Scott Whitlow; Jeff DeVido; Dan Foy; Jayanta Chaudhuri; David Lombard; Frederick W Alt
Leaky Scid phenotype associated with defective V(D)J coding end processing in Artemis-deficient mice.
Molecular cell 2002;10(6):1379-90.
2002: Xiao-Feng Yang; Qunrui Ye; Barry Press; Rui-Zhu Han; Craig H Bassing; Barry P Sleckman; Frederick W Alt; Harvey Cantor
Analysis of the complex genomic structure of Bcl-x and its relationship to Bcl-x(gamma) expression after CD28-dependent costimulation.
Molecular immunology 2002;39(1-2):45-55.
2002: Darryll D Dudley; John P Manis; Ali A Zarrin; Lianne Kaylor; Ming Tian; Frederick W Alt
Internal IgH class switch region deletions are position-independent and enhanced by AID expression.
Proceedings of the National Academy of Sciences of the United States of America 2002;99(15):9984-9.
2002: Deborah C Solymar; Suneet Agarwal; Craig H Bassing; Frederick W Alt; Anjana Rao
A 3' enhancer in the IL-4 gene regulates cytokine production by Th2 cells and mast cells.
Immunity 2002;17(1):41-50.
2002: Qunrui Ye; Barry Press; Stephan Kissler; Xiao-Feng Yang; Linrong Lu; Craig H Bassing; Barry P Sleckman; Marianne Jansson; Vily Panoutsakopoulou; Linda A Trimble; Frederick W Alt; Harvey Cantor
T cell costimulation through CD28 depends on induction of the Bcl-xgamma isoform: analysis of Bcl-xgamma-deficient mice.
The Journal of experimental medicine 2002;196(1):87-95.
2002: Chengming Zhu; Kevin D Mills; David O Ferguson; Charles Lee; John P Manis; James Fleming; Yijie Gao; Cynthia C Morton; Frederick W Alt
Unrepaired DNA breaks in p53-deficient cells lead to oncogenic gene amplification subsequent to translocations.
Cell 2002;109(7):811-21.
2002: Craig H Bassing; Katrin F Chua; JoAnn Sekiguchi; Heikyung Suh; Scott Whitlow; Judith C Fleming; Brianna C Monroe; David N Ciccone; Catherine Yan; Katerina Vlasakova; David M Livingston; David O Ferguson; Ralph Scully; Frederick W Alt
Increased ionizing radiation sensitivity and genomic instability in the absence of histone H2AX.
Proceedings of the National Academy of Sciences of the United States of America 2002;99(12):8173-8.
2002: Katrin F Chua; Frederick W Alt; John P Manis
The function of AID in somatic mutation and class switch recombination: upstream or downstream of DNA breaks.
The Journal of experimental medicine 2002;195(9):F37-41.
2002: Matthew A Inlay; Frederick W Alt; David Baltimore; Yang Xu
Essential roles of the kappa light chain intronic enhancer and 3' enhancer in kappa rearrangement and demethylation.
Nature immunology 2002;3(5):463-8.
2002: Craig H Bassing; Wojciech Swat; Frederick W Alt
The mechanism and regulation of chromosomal V(D)J recombination.
Cell 2002;109 Suppl():S45-55.
2002: John P Manis; Darryll D Dudley; Lianne Kaylor; Frederick W Alt
IgH class switch recombination to IgG1 in DNA-PKcs-deficient B cells.
Immunity 2002;16(4):607-17.
2002: Barbara A Malynn; Albert C Shaw; Faith Young; Valerie Stewart; Frederick W Alt
Truncated immunoglobulin Dmu causes incomplete developmental progression of RAG-deficient pro-B cells.
Molecular immunology 2002;38(7):547-56.
2001: Norman E Sharpless; David O Ferguson; Rónán C O'Hagan; Diego H Castrillon; C Lee; P A Farazi; Scott Alson; J Fleming; C C Morton; K Frank; Lynda Chin; Frederick W Alt; Ronald A DePinho
Impaired nonhomologous end-joining provokes soft tissue sarcomas harboring chromosomal translocations, amplifications, and deletions.
Molecular cell 2001;8(6):1187-96.
2001: Erdyni N Tsitsikov; Dhafer Laouini; IF Dunn; T Y Sannikova; L Davidson; Frederick W Alt; Raif S Geha
TRAF1 is a negative regulator of TNF signaling. enhanced TNF signaling in TRAF1-deficient mice.
Immunity 2001;15(4):647-57.
2001: David O Ferguson; Frederick W Alt
DNA double strand break repair and chromosomal translocation: lessons from animal models.
Oncogene 2001;20(40):5572-9.
2001: JoAnn Sekiguchi; David O Ferguson; H T Chen; E M Yang; J Earle; K Frank; Scott Whitlow; Yansong Gu; Y Xu; A Nussenzweig; Frederick W Alt
Genetic interactions between ATM and the nonhomologous end-joining factors in genomic stability and development.
Proceedings of the National Academy of Sciences of the United States of America 2001;98(6):3243-8.
2001: IM de Alboran; Rónán C O'Hagan; F Gärtner; Barbara A Malynn; L Davidson; R Rickert; K Rajewsky; Ronald A DePinho; Frederick W Alt
Analysis of C-MYC function in normal cells via conditional gene-targeted mutation.
Immunity 2001;14(1):45-55.
2000: F Gärtner; Frederick W Alt; Robert J Monroe; K J Seidl
Antigen-independent appearance of recombination activating gene (RAG)-positive bone marrow B cells in the spleens of immunized mice.
The Journal of experimental medicine 2000;192(12):1745-54.
2000: Kwok-Kin Wong; S Chang; Sarah R Weiler; S Ganesan; Jayanta Chaudhuri; C Zhu; Steven E Artandi; K Lenhard Rudolph; GJ Gottlieb; Lynda Chin; Frederick W Alt; Ronald A DePinho
Telomere dysfunction impairs DNA repair and enhances sensitivity to ionizing radiation.
Nature genetics 2000;26(1):85-8.
2000: Rónán C O'Hagan; Michael Ohh; Gregory David; IM de Alboran; Frederick W Alt; William G Kaelin; Ronald A DePinho
Myc-enhanced expression of Cul1 promotes ubiquitin-dependent proteolysis and cell cycle progression.
Genes & development 2000;14(17):2185-91.
2000: Sheri L Moores; L M Selfors; Jessica Fredericks; T Breit; Keiko Fujikawa; Frederick W Alt; Joan S Brugge; Wojciech Swat
Vav family proteins couple to diverse cell surface receptors.
Molecular and cellular biology 2000;20(17):6364-73.
2000: Ming Tian; Frederick W Alt
Transcription-induced cleavage of immunoglobulin switch regions by nucleotide excision repair nucleases in vitro.
The Journal of biological chemistry 2000;275(31):24163-72.
2000: Barry P Sleckman; Craig H Bassing; Maureen M Hughes; A Okada; M D'Auteuil; Tara D Wehrly; Barbara B Woodman; L Davidson; J Chen; Frederick W Alt
Mechanisms that direct ordered assembly of T cell receptor beta locus V, D, and J gene segments.
Proceedings of the National Academy of Sciences of the United States of America 2000;97(14):7975-80.
2000: David O Ferguson; JoAnn Sekiguchi; S Chang; KM Frank; Yijie Gao; Ronald A DePinho; Frederick W Alt
The nonhomologous end-joining pathway of DNA repair is required for genomic stability and the suppression of translocations.
Proceedings of the National Academy of Sciences of the United States of America 2000;97(12):6630-3.
2000: KM Frank; Norman E Sharpless; Yijie Gao; JoAnn Sekiguchi; David O Ferguson; Chengming Zhu; John P Manis; J Horner; Ronald A DePinho; Frederick W Alt
DNA ligase IV deficiency in mice leads to defective neurogenesis and embryonic lethality via the p53 pathway.
Molecular cell 2000;5(6):993-1002.
2000: Craig H Bassing; Frederick W Alt; Maureen M Hughes; M D'Auteuil; Tara D Wehrly; Barbara B Woodman; F Gärtner; J M White; L Davidson; Barry P Sleckman
Recombination signal sequences restrict chromosomal V(D)J recombination beyond the 12/23 rule.
Nature 2000;405(6786):583-6.
2000: Barbara A Malynn; IM de Alboran; Rónán C O'Hagan; R Bronson; L Davidson; Ronald A DePinho; Frederick W Alt
N-myc can functionally replace c-myc in murine development, cellular growth, and differentiation.
Genes & development 2000;14(11):1390-9.
2000: Barry P Sleckman; Wasif Khan; W Xu; Craig H Bassing; Barbara A Malynn; N G Copeland; CG Bardon; T M Breit; L Davidson; E M Oltz; N A Jenkins; J E Berman; Frederick W Alt
Cloning and functional characterization of the early-lymphocyte-specific Pb99 gene.
Molecular and cellular biology 2000;20(12):4405-10.
2000: Yijie Gao; David O Ferguson; W Xie; John P Manis; JoAnn Sekiguchi; KM Frank; Jayanta Chaudhuri; J Horner; Ronald A DePinho; Frederick W Alt
Interplay of p53 and DNA-repair protein XRCC4 in tumorigenesis, genomic stability and development.
Nature 2000;404(6780):897-900.
2000: Paul R Borghesani; Frederick W Alt; A Bottaro; L Davidson; S Aksoy; GA Rathbun; Thomas M Roberts; Wojciech Swat; Rosalind A Segal; Yansong Gu
Abnormal development of Purkinje cells and lymphocytes in Atm mutant mice.
Proceedings of the National Academy of Sciences of the United States of America 2000;97(7):3336-41.
2000: Yansong Gu; JoAnn Sekiguchi; Yijie Gao; Pieter Dikkes; K Frank; David O Ferguson; Edward Hasty; J Chun; Frederick W Alt
Defective embryonic neurogenesis in Ku-deficient but not DNA-dependent protein kinase catalytic subunit-deficient mice.
Proceedings of the National Academy of Sciences of the United States of America 2000;97(6):2668-73.
2000: David O Ferguson; JoAnn Sekiguchi; KM Frank; Y Gao; Norman E Sharpless; Yansong Gu; John P Manis; Ronald A DePinho; Frederick W Alt
The interplay between nonhomologous end-joining and cell cycle checkpoint factors in development, genomic stability, and tumorigenesis.
Cold Spring Harbor symposia on quantitative biology 2000;65():395-403.
1999: Robert J Monroe; F Chen; R Ferrini; L Davidson; Frederick W Alt
RAG2 is regulated differentially in B and T cells by elements 5' of the promoter.
Proceedings of the National Academy of Sciences of the United States of America 1999;96(22):12713-8.
1999: Ioannis Aifantis; Vadim Pivniouk; F Gärtner; J Feinberg; Wojciech Swat; Frederick W Alt; Harald von Boehmer; Raif S Geha
Allelic exclusion of the T cell receptor beta locus requires the SH2 domain-containing leukocyte protein (SLP)-76 adaptor protein.
The Journal of experimental medicine 1999;190(8):1093-102.
1999: E Sakai; Andrea Bottaro; Frederick W Alt
The Ig heavy chain intronic enhancer core region is necessary and sufficient to promote efficient class switch recombination.
International immunology 1999;11(10):1709-13.
1999: Robert J Monroe; KJ Seidl; F Gaertner; S Han; F Chen; JoAnn Sekiguchi; J Wang; R Ferrini; L Davidson; Garnett Kelsoe; Frederick W Alt
RAG2:GFP knockin mice reveal novel aspects of RAG2 expression in primary and peripheral lymphoid tissues.
Immunity 1999;11(2):201-12.
1999: Z Wang; DE Yunis; M Irigoyen; B Kitchens; A Bottaro; Frederick W Alt; Chester A Alper
Discordance between IgA switching at the DNA level and IgA expression at the mRNA level in IgA-deficient patients.
Clinical immunology (Orlando, Fla.) 1999;91(3):263-70.
1999: F Gärtner; Frederick W Alt; Robert J Monroe; M Chu; Barry P Sleckman; L Davidson; Wojciech Swat
Immature thymocytes employ distinct signaling pathways for allelic exclusion versus differentiation and expansion.
Immunity 1999;10(5):537-46.
1999: Robert J Monroe; Barry P Sleckman; B C Monroe; Bernard Khor; Steven Claypool; R Ferrini; L Davidson; Frederick W Alt
Developmental regulation of TCR delta locus accessibility and expression by the TCR delta enhancer.
Immunity 1999;10(5):503-13.
1999: K J Seidl; John P Manis; A Bottaro; J Zhang; L Davidson; A Kisselgof; H Oettgen; Frederick W Alt
Position-dependent inhibition of class-switch recombination by PGK-neor cassettes inserted into the immunoglobulin heavy chain constant region locus.
Proceedings of the National Academy of Sciences of the United States of America 1999;96(6):3000-5.
1999: Albert C Shaw; Wojciech Swat; L Davidson; Frederick W Alt
Induction of Ig light chain gene rearrangement in heavy chain-deficient B cells by activated Ras.
Proceedings of the National Academy of Sciences of the United States of America 1999;96(5):2239-43.
1999: E Sakai; Andrea Bottaro; L Davidson; Barry P Sleckman; Frederick W Alt
Recombination and transcription of the endogenous Ig heavy chain locus is effected by the Ig heavy chain intronic enhancer core region in the absence of the matrix attachment regions.
Proceedings of the National Academy of Sciences of the United States of America 1999;96(4):1526-31.
1999: Albert C Shaw; Wojciech Swat; R Ferrini; L Davidson; Frederick W Alt
Activated Ras signals developmental progression of recombinase-activating gene (RAG)-deficient pro-B lymphocytes.
The Journal of experimental medicine 1999;189(1):123-9.
1999: JoAnn Sekiguchi; Y Gao; Yansong Gu; K Frank; Yi E Sun; Jayanta Chaudhuri; Chengming Zhu; Hwei-Ling Cheng; John P Manis; David O Ferguson; L Davidson; Michael E Greenberg; Frederick W Alt
Nonhomologous end-joining proteins are required for V(D)J recombination, normal growth, and neurogenesis.
Cold Spring Harbor symposia on quantitative biology 1999;64():169-81.
1998: Yijie Gao; Yi E Sun; KM Frank; Pieter Dikkes; Y Fujiwara; KJ Seidl; JoAnn Sekiguchi; GA Rathbun; Wojciech Swat; J Wang; Roderick T Bronson; Barbara A Malynn; M Bryans; Chengming Zhu; Jayanta Chaudhuri; L Davidson; R Ferrini; Thomas D Stamato; Stuart H Orkin; Michael E Greenberg; Frederick W Alt
A critical role for DNA end-joining proteins in both lymphogenesis and neurogenesis.
Cell 1998;95(7):891-902.
1998: KM Frank; JoAnn Sekiguchi; KJ Seidl; Wojciech Swat; GA Rathbun; H L Cheng; L Davidson; L Kangaloo; Frederick W Alt
Late embryonic lethality and impaired V(D)J recombination in mice lacking DNA ligase IV.
Nature 1998;396(6707):173-7.
1998: K J Seidl; A Bottaro; A Vo; J Zhang; L Davidson; Frederick W Alt
An expressed neo(r) cassette provides required functions of the 1gamma2b exon for class switching.
International immunology 1998;10(11):1683-92.
1998: Barry P Sleckman; Bernard Khor; Robert J Monroe; Frederick W Alt
Assembly of productive T cell receptor delta variable region genes exhibits allelic inclusion.
The Journal of experimental medicine 1998;188(8):1465-71.
1998: John P Manis; N van der Stoep; M Tian; R Ferrini; L Davidson; A Bottaro; Frederick W Alt
Class switching in B cells lacking 3' immunoglobulin heavy chain enhancers.
The Journal of experimental medicine 1998;188(8):1421-31.
1998: Barry P Sleckman; Craig H Bassing; CG Bardon; A Okada; Bernard Khor; J C Bories; Robert J Monroe; Frederick W Alt
Accessibility control of variable region gene assembly during T-cell development.
Immunological reviews 1998;165():121-30.
1998: Yijie Gao; Jayanta Chaudhuri; Chengming Zhu; L Davidson; David Weaver; Frederick W Alt
A targeted DNA-PKcs-null mutation reveals DNA-PK-independent functions for KU in V(D)J recombination.
Immunity 1998;9(3):367-76.
1998: K Cunningham; H Ackerly; L Claflin; J Collins; P Wu; C Ford; R Lansford; Frederick W Alt; Wesley A Dunnick
Germline transcription and recombination of a murine VDJmudeltagamma1 transgene.
International immunology 1998;10(8):1027-37.
1998: L C Wang; Wojciech Swat; Y Fujiwara; L Davidson; J Visvader; F Kuo; Frederick W Alt; D Gary Gilliland; Todd R Golub; Stuart H Orkin
The TEL/ETV6 gene is required specifically for hematopoiesis in the bone marrow.
Genes & development 1998;12(15):2392-402.
1998: Vadim Pivniouk; Erdyni N Tsitsikov; P Swinton; G Rathbun; Frederick W Alt; Raif S Geha
Impaired viability and profound block in thymocyte development in mice lacking the adaptor protein SLP-76.
Cell 1998;94(2):229-38.
1998: Scott B Snapper; Fred S Rosen; Emiko Mizoguchi; P Cohen; Wasif Khan; C H Liu; TL Hagemann; SP Kwan; R Ferrini; L Davidson; Atul K Bhan; Frederick W Alt
Wiskott-Aldrich syndrome protein-deficient mice reveal a role for WASP in T but not B cell activation.
Immunity 1998;9(1):81-91.
1998: John P Manis; Yansong Gu; R Lansford; E Sonoda; R Ferrini; L Davidson; K Rajewsky; Frederick W Alt
Ku70 is required for late B cell development and immunoglobulin heavy chain class switching.
The Journal of experimental medicine 1998;187(12):2081-9.
1998: Andrea Bottaro; Faith Young; Jianzhu Chen; M Serwe; F Sablitzky; Frederick W Alt
Deletion of the IgH intronic enhancer and associated matrix-attachment regions decreases, but does not abolish, class switching at the mu locus.
International immunology 1998;10(6):799-806.
1998: BA Irving; Frederick W Alt; Nigel Killeen
Thymocyte development in the absence of pre-T cell receptor extracellular immunoglobulin domains.
Science (New York, N.Y.) 1998;280(5365):905-8.
1998: Wojciech Swat; K Fujikawa; Soula Ganiatsas; D Yang; Ramnik Xavier; N L Harris; L Davidson; R Ferrini; R J Davis; Mark Labow; R A Flavell; Leonard I Zon; Frederick W Alt
SEK1/MKK4 is required for maintenance of a normal peripheral lymphoid compartment but not for lymphocyte development.
Immunity 1998;8(5):625-34.
1998: K Cunningham; H Ackerly; Frederick W Alt; Wesley A Dunnick
Potential regulatory elements for germline transcription in or near murine Sgamma1.
International immunology 1998;10(4):527-36.
1998: R Lansford; John P Manis; E Sonoda; K Rajewsky; Frederick W Alt
Ig heavy chain class switching in Rag-deficient mice.
International immunology 1998;10(3):325-32.
1998: J R Gorman; Frederick W Alt
Regulation of immunoglobulin light chain isotype expression.
Advances in immunology 1998;69():113-81.
1997: Yansong Gu; KJ Seidl; GA Rathbun; Chengming Zhu; John P Manis; N van der Stoep; L Davidson; Hwei-Ling Cheng; JoAnn Sekiguchi; K Frank; P Stanhope-Baker; Mark S Schlissel; David B Roth; Frederick W Alt
Growth retardation and leaky SCID phenotype of Ku70-deficient mice.
Immunity 1997;7(5):653-65.
1997: Barry P Sleckman; CG Bardon; R Ferrini; L Davidson; Frederick W Alt
Function of the TCR alpha enhancer in alphabeta and gammadelta T cells.
Immunity 1997;7(4):505-15.
1997: R Mizuta; H L Cheng; Y Gao; Frederick W Alt
Molecular genetic characterization of XRCC4 function.
International immunology 1997;9(10):1607-13.
1997: Yansong Gu; S Jin; Yijie Gao; David Weaver; Frederick W Alt
Ku70-deficient embryonic stem cells have increased ionizing radiosensitivity, defective DNA end-binding activity, and inability to support V(D)J recombination.
Proceedings of the National Academy of Sciences of the United States of America 1997;94(15):8076-81.
1997: R Mizuta; Janine M LaSalle; Hwei-Ling Cheng; A Shinohara; H Ogawa; N Copeland; N A Jenkins; Marc Lalande; Frederick W Alt
RAB22 and RAB163/mouse BRCA2: proteins that specifically interact with the RAD51 protein.
Proceedings of the National Academy of Sciences of the United States of America 1997;94(13):6927-32.
1997: F Young; Emiko Mizoguchi; Atul K Bhan; Frederick W Alt
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