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Thomas Darga

Research Profile

Living Beings

Anatomy

Phenomena

Radiation, Ionizing

Chemicals & Drugs

Procedures

Physiology

Disorders

Experimental Melanomas

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Publications

TOP 3
Yuru Meng; Thomas E Darga; Elena V Efimova; Yang-Xin Fu; Khaled W Hamzeh; Stephen J Kron; Helena J Mauceri; Ralph R Weichselbaum
Radiation-inducible immunotherapy for cancer: senescent tumor cells as a cancer vaccine.
Helena J Mauceri; Harold G Sutton; Thomas E Darga; Joel Kochanski; Masha Kocherginsky; Ralph R Weichselbaum; Everett E Vokes
Everolimus exhibits efficacy as a radiosensitizer in a model of non-small cell lung cancer.
Yves A Lussier; Philip B Paty; Mitchell C Posner; Kelly Regan; Steven J Chmura; Kimberly Corbin; Thomas E Darga; Hanli Fan; Mark K Ferguson; Sabha Ganai; Jennifer Gnerlich; Samuel Hellman; Oleksiy Karpenko; Sajid A Khan; Nikolai N Khodarev; Haiquan Li; Ralph R Weichselbaum
Oligo- and polymetastatic progression in lung metastasis(es) patients is associated with specific microRNAs.

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All Publications

2012: Yuru Meng; Thomas E Darga; Elena V Efimova; Yang-Xin Fu; Khaled W Hamzeh; Stephen J Kron; Helena J Mauceri; Ralph R Weichselbaum
Radiation-inducible immunotherapy for cancer: senescent tumor cells as a cancer vaccine.
Molecular therapy : the journal of the American Society of Gene Therapy 2012;20(5):1046-55.
2012: Helena J Mauceri; Harold G Sutton; Thomas E Darga; Joel Kochanski; Masha Kocherginsky; Ralph R Weichselbaum; Everett E Vokes
Everolimus exhibits efficacy as a radiosensitizer in a model of non-small cell lung cancer.
Oncology reports 2012;27(5):1625-9.
2012: Yves A Lussier; Philip B Paty; Mitchell C Posner; Kelly Regan; Steven J Chmura; Kimberly Corbin; Thomas E Darga; Hanli Fan; Mark K Ferguson; Sabha Ganai; Jennifer Gnerlich; Samuel Hellman; Oleksiy Karpenko; Sajid A Khan; Nikolai N Khodarev; Haiquan Li; Ralph R Weichselbaum
Oligo- and polymetastatic progression in lung metastasis(es) patients is associated with specific microRNAs.
PloS one 2012;7(12):e50141.
2012: Sean P Pitroda; Harold G Sutton; Randy F Sweis; Wei Zhang; Tong Zhou; Michael A Beckett; Thomas E Darga; Matthew Filippo; Joe G. N. Garcia; Sajid A Khan; Nikolai N Khodarev; Edwardine Labay; Hua Liang; Helena J Mauceri; Samantha Perakis; Ralph R Weichselbaum
Tumor endothelial inflammation predicts clinical outcome in diverse human cancers.
PloS one 2012;7(10):e46104.
2011: Juan Camilo Barreto-Andrade; Michael A Beckett; Thomas E Darga; Elena V Efimova; Stephen J Kron; Helena J Mauceri; Mitchell C Posner; Harold G Sutton; Everett E Vokes; Ralph R Weichselbaum
Response of human prostate cancer cells and tumors to combining PARP inhibition with ionizing radiation.
Molecular cancer therapeutics 2011;10(7):1185-93.
2010: Elena V Efimova; Helena J Mauceri; Daniel W Golden; Edwardine Labay; Vytautas P Bindokas; Thomas E Darga; Chaitali Chakraborty; Juan Camilo Barreto-Andrade; Clayton Crawley; Harold G Sutton; Stephen J Kron; Ralph R Weichselbaum
Poly(ADP-ribose) polymerase inhibitor induces accelerated senescence in irradiated breast cancer cells and tumors.
Cancer research 2010;70(15):6277-82.
2010: Yuru Meng; Helena J Mauceri; Nikolai N Khodarev; Thomas E Darga; Sean P Pitroda; Michael A Beckett; Donald W Kufe; Ralph R Weichselbaum
Ad.Egr-TNF and local ionizing radiation suppress metastases by interferon-beta-dependent activation of antigen-specific CD8+ T cells.
Molecular therapy : the journal of the American Society of Gene Therapy 2010;18(5):912-20.
2009: Elena V Efimova; Hua Liang; Sean P Pitroda; Edwardine Labay; Thomas E Darga; Vera Levina; Anna Lokshin; Bernard Roizman; Ralph R Weichselbaum; Nikolai N Khodarev
Radioresistance of Stat1 over-expressing tumour cells is associated with suppressed apoptotic response to cytotoxic agents and increased IL6-IL8 signalling.
International journal of radiation biology 2009;85(5):421-31.
2009: Helena J Mauceri; Michael A Beckett; H Liang; H G Sutton; S Pitroda; E Galka; E Efimova; Thomas E Darga; N N Khodarev; C Richter King; Mitchell C Posner; Samuel Hellman; Donald Kufe; Ralph R Weichselbaum
Translational strategies exploiting TNF-alpha that sensitize tumors to radiation therapy.
Cancer gene therapy 2009;16(4):373-81.
2009: Nikolai N Khodarev; Paul Roach; Sean P Pitroda; Daniel W Golden; Mihir Bhayani; Michael Y Shao; Thomas E Darga; Mara G Beveridge; Ravi F Sood; Harold G Sutton; Michael A Beckett; Helena J Mauceri; Mitchell C Posner; Ralph R Weichselbaum
STAT1 pathway mediates amplification of metastatic potential and resistance to therapy.
PloS one 2009;4(6):e5821.
2007: Mukta Katdare; Elena V Efimova; Edwardine Labay; Nikolai N Khodarev; Thomas E Darga; Michael C Garofalo; Satoaki Nakamura; Donald Kufe; Mitchell C Posner; Ralph R Weichselbaum
Diverse TNFalpha-induced death pathways are enhanced by inhibition of NF-kappaB.
International journal of oncology 2007;31(6):1519-28.
2007: Nikolai N Khodarev; Andy J Minn; Elena V Efimova; Thomas E Darga; Edwardine Labay; Michael A Beckett; Helena J Mauceri; Bernard Roizman; Ralph R Weichselbaum
Signal transducer and activator of transcription 1 regulates both cytotoxic and prosurvival functions in tumor cells.
Cancer research 2007;67(19):9214-20.
2005: James Mezhir; Sunil J Advani; Kerrington D Smith; Thomas E Darga; Alice P W Poon; Hank Schmidt; Mitchell C Posner; Bernard Roizman; Ralph R Weichselbaum
Ionizing radiation activates late herpes simplex virus 1 promoters via the p38 pathway in tumors treated with oncolytic viruses.
Cancer research 2005;65(20):9479-84.
2005: Eric T Kimchi; Mitchell C Posner; James Park; Thomas E Darga; Masha Kocherginsky; Theodore Karrison; John Hart; Kerrington D Smith; James Mezhir; Ralph R Weichselbaum; Nikolai N Khodarev
Progression of Barrett's metaplasia to adenocarcinoma is associated with the suppression of the transcriptional programs of epidermal differentiation.
Cancer research 2005;65(8):3146-54.
2004: Charles K Brown; Nikolai N Khodarev; Jianqing Yu; Tricia Moo-Young; Edwardine Labay; Thomas E Darga; Mitchell C Posner; Ralph R Weichselbaum; Helena J Mauceri
Glioblastoma cells block radiation-induced programmed cell death of endothelial cells.
FEBS letters 2004;565(1-3):167-70.
2004: Nikolai N Khodarev; Edwardine Labay; Thomas E Darga; Jianqing Yu; Helena J Mauceri; Nalin Gupta; Yasushi Kataoka; Ralph R Weichselbaum
Endothelial cells co-cultured with wild-type and dominant/negative p53-transfected glioblastoma cells exhibit differential sensitivity to radiation-induced apoptosis.
International journal of cancer. Journal international du cancer 2004;109(2):214-9.
2004: Nikolai N Khodarev; Michael A Beckett; Edwardine Labay; Thomas E Darga; Bernard Roizman; Ralph R Weichselbaum
STAT1 is overexpressed in tumors selected for radioresistance and confers protection from radiation in transduced sensitive cells.
Proceedings of the National Academy of Sciences of the United States of America 2004;101(6):1714-9.
2003: Nikolai N Khodarev; Jianqing Yu; Edwardine Labay; Thomas E Darga; Charles K Brown; Helena J Mauceri; Reza Yassari; Nalin Gupta; Ralph R Weichselbaum
Tumour-endothelium interactions in co-culture: coordinated changes of gene expression profiles and phenotypic properties of endothelial cells.
Journal of cell science 2003;116(Pt 6):1013-22.
2002: James Park; Carlos A Lopez; Vinay K Gupta; Charles K Brown; Helena J Mauceri; Thomas E Darga; Abdullah Manan; Samuel Hellman; Mitchell C Posner; Donald Kufe; Ralph R Weichselbaum
Transcriptional control of viral gene therapy by cisplatin.
The Journal of clinical investigation 2002;110(3):403-10.

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