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Frédéric Darios

Research Profile

Chemicals & Drugs

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Rats
Mouse

Anatomy

Physiology

Cell Death

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Publications

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Jesica Raingo; Denise M O Ramirez; Katalin Toth; Megumi Adachi; Frédéric Darios; Bazbek Davletov; Mikhail Khvotchev; Philippe Lemieux; Ying C Li; Pei Liu; Ege T Kavalali
VAMP4 directs synaptic vesicles to a pool that selectively maintains asynchronous neurotransmission.
Frédéric Darios
[A modular and non pathogenic type A botulinum toxin].
Reena Prity Murmu; Elodie Martin; Agnès Rastetter; Typhaine Esteves; Marie-Paule Muriel; Khalid Hamid El Hachimi; Paola Silvia Denora; Aurélien Dauphin; José Carlos Fernandez; Charles Duyckaerts; Alexis Brice; Frédéric Darios; Giovanni Stevanin
Cellular distribution and subcellular localization of spatacsin and spastizin, two proteins involved in hereditary spastic paraplegia.

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All Publications

2012: Jesica Raingo; Denise M O Ramirez; Katalin Toth; Megumi Adachi; Frédéric Darios; Bazbek Davletov; Mikhail Khvotchev; Philippe Lemieux; Ying C Li; Pei Liu; Ege T Kavalali
VAMP4 directs synaptic vesicles to a pool that selectively maintains asynchronous neurotransmission.
Nature neuroscience 2012;15(5):738-45.
2011: Frédéric Darios
[A modular and non pathogenic type A botulinum toxin].
Médecine sciences : M/S 2011;27(8-9):694-6.
2011: Reena Prity Murmu; Elodie Martin; Agnès Rastetter; Typhaine Esteves; Marie-Paule Muriel; Khalid Hamid El Hachimi; Paola Silvia Denora; Aurélien Dauphin; José Carlos Fernandez; Charles Duyckaerts; Alexis Brice; Frédéric Darios; Giovanni Stevanin
Cellular distribution and subcellular localization of spatacsin and spastizin, two proteins involved in hereditary spastic paraplegia.
Molecular and cellular neurosciences 2011;47(3):191-202.
2010: Frédéric Darios; Dhevahi Niranjan; Enrico Ferrari; Fan Zhang; Mikhail Soloviev; Andreas Rummel; Hans Bigalke; Jason Suckling; Yuri Ushkaryov; Nikolay Naumenko; Anastasia Shakirzyanova; Rashid Giniatullin; Elizabeth S Maywood; Michael Hastings; Thomas Binz; Bazbek Davletov
SNARE tagging allows stepwise assembly of a multimodular medicinal toxin.
Proceedings of the National Academy of Sciences of the United States of America 2010;107(42):18197-201.
2010: Violeta Ruipérez; Frédéric Darios; Bazbek Davletov
Alpha-synuclein, lipids and Parkinson's disease.
Progress in lipid research 2010;49(4):420-8.
2010: Frédéric Darios; Violeta Ruipérez; Inmaculada López; Jose Villanueva; Luis M Gutierrez; Bazbek Davletov
Alpha-synuclein sequesters arachidonic acid to modulate SNARE-mediated exocytosis.
EMBO reports 2010;11(7):528-33.
2010: Enrico Ferrari; Frédéric Darios; Fan Zhang; Dhevahi Niranjan; Julian Bailes; Mikhail Soloviev; Bazbek Davletov
Binary polypeptide system for permanent and oriented protein immobilization.
Journal of nanobiotechnology 2010;8():9.
2009: Emma Connell; Frédéric Darios; Sew-Yeu Peak Chew; Mikhail Soloviev; Bazbek Davletov
N-terminal acetylation of the neuronal protein SNAP-25 is revealed by the SMI81 monoclonal antibody.
Biochemistry 2009;48(40):9582-9.
2009: Frédéric Darios; Catherine Wasser; Anastasia Shakirzyanova; Artur Giniatullin; Kerry Goodman; Jose L Munoz-Bravo; Jesica Raingo; Jernej Jorgacevski; Marko Kreft; Robert Zorec; Juliana M Rosa; Luis Gandia; Luis M Gutiérrez; Thomas Binz; Rashid Giniatullin; Ege T Kavalali; Bazbek Davletov
Sphingosine facilitates SNARE complex assembly and activates synaptic vesicle exocytosis.
Neuron 2009;62(5):683-94.
2007: Frédéric Darios; Emma Connell; Bazbek Davletov
Phospholipases and fatty acid signalling in exocytosis.
The Journal of physiology 2007;585(Pt 3):699-704.
2007: Bazbek Davletov; Emma Connell; Frédéric Darios
Regulation of SNARE fusion machinery by fatty acids.
Cellular and molecular life sciences : CMLS 2007;64(13):1597-608.
2007: Emma Connell; Frédéric Darios; Kerensa Broersen; Naomi Gatsby; Sew-Yeu Peak Chew; Colin Rickman; Bazbek Davletov
Mechanism of arachidonic acid action on syntaxin-Munc18.
EMBO reports 2007;8(4):414-9.
2006: AR Giniatullin; Frédéric Darios; A Shakirzyanova; Bazbek Davletov; Rashid Giniatullin
SNAP25 is a pre-synaptic target for the depressant action of reactive oxygen species on transmitter release.
Journal of neurochemistry 2006;98(6):1789-97.
2006: Frédéric Darios; Bazbek Davletov
Omega-3 and omega-6 fatty acids stimulate cell membrane expansion by acting on syntaxin 3.
Nature 2006;440(7085):813-7.
2006: Paul Unschuld; J Dächsel; Frédéric Darios; Alexander Kohlmann; E Casademunt; K Lehmann-Horn; M Dichgans; Merle Ruberg; Alexis Brice; Thomas Gasser; Christoph B Lücking
Parkin modulates gene expression in control and ceramide-treated PC12 cells.
Molecular biology reports 2006;33(1):13-32.
2005: Mark Bajohrs; Frédéric Darios; Sew-Yeu Peak Chew; Bazbek Davletov
Promiscuous interaction of SNAP-25 with all plasma membrane syntaxins in a neuroendocrine cell.
The Biochemical journal 2005;392(Pt 2):283-9.
2005: Frédéric Darios; Marie-Paule Muriel; Myriam Escobar Khondiker; Alexis Brice; Merle Ruberg
Neurotoxic calcium transfer from endoplasmic reticulum to mitochondria is regulated by cyclin-dependent kinase 5-dependent phosphorylation of tau.
The Journal of neuroscience : the official journal of the Society for Neuroscience 2005;25(16):4159-68.
2005: Olga Corti; Cornelia Hampe; Frédéric Darios; Pablo Ibanez; Merle Ruberg; Alexis Brice
Parkinson's disease: from causes to mechanisms.
Comptes rendus biologies 2005;328(2):131-42.
2003: Olga Corti; Cornelia Hampe; Hana Koutnikova; Frédéric Darios; Sandrine Jacquier; Annick Prigent; Jean-Charles Robinson; Laurent Pradier; Merle Ruberg; Marc Mirande; Etienne C Hirsch; Thomas Rooney; Alain Fournier; Alexis Brice
The p38 subunit of the aminoacyl-tRNA synthetase complex is a Parkin substrate: linking protein biosynthesis and neurodegeneration.
Human molecular genetics 2003;12(12):1427-37.
2003: Frédéric Darios; Olga Corti; Christoph B Lücking; Cornelia Hampe; Marie-Paule Muriel; Nacer Abbas; Wen-Jie Gu; Etienne C Hirsch; Thomas Rooney; Merle Ruberg; Alexis Brice
Parkin prevents mitochondrial swelling and cytochrome c release in mitochondria-dependent cell death.
Human molecular genetics 2003;12(5):517-26.
2003: Frédéric Darios; Nathalie Lambeng; jean-denis troadec; Patrick P Michel; Merle Ruberg
Ceramide increases mitochondrial free calcium levels via caspase 8 and Bid: role in initiation of cell death.
Journal of neurochemistry 2003;84(4):643-54.
2003: Annie Lannuzel; Patrick P Michel; Günter U Höglinger; Pierre Champy; A Jousset; Fadia Medja; Anne Lombès; Frédéric Darios; Christophe Gleye; Alain Laurens; Reynald Hocquemiller; Etienne C Hirsch; Merle Ruberg
The mitochondrial complex I inhibitor annonacin is toxic to mesencephalic dopaminergic neurons by impairment of energy metabolism.
Neuroscience 2003;121(2):287-96.
2001: jean-denis troadec; Marc Marien; Frédéric Darios; Andreas Hartmann; Merle Ruberg; Francis Colpaert; Patrick P Michel
Noradrenaline provides long-term protection to dopaminergic neurons by reducing oxidative stress.
Journal of neurochemistry 2001;79(1):200-10.
2000: Marie-Paule Muriel; Nathalie Lambeng; Frédéric Darios; Patrick P Michel; Etienne C Hirsch; Yves Agid; Merle Ruberg
Mitochondrial free calcium levels (Rhod-2 fluorescence) and ultrastructural alterations in neuronally differentiated PC12 cells during ceramide-dependent cell death.
The Journal of comparative neurology 2000;426(2):297-315.