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Marilyn Darkes

Research Profile

Chemicals & Drugs

Anatomy

Phenomena

Physiology

Signal Transduction

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Publications

TOP 3
Renee Mosi; Kim L Nelson; Ketan Patel; Zefferino Santucci; Dominique Schols; Renato T Skerlj; Rebecca S Y Wong; Virginia Anastassova; Gary J Bridger; Jennifer Cox; Marilyn C Darkes; Dana Huskens; Stefan R Idzan; Jean Labrecque; Gloria Lau; Simon P Fricker
The molecular pharmacology of AMD11070: an orally bioavailable CXCR4 HIV entry inhibitor.
Markus Metz; Zefferino Santucci; Dominique Schols; Wen Yang; Elyse Bourque; Gary J Bridger; Sanjay J Danthi; Marilyn C Darkes; Simon P Fricker; Curtis Harwig; Jean Labrecque; Jonathan Langille; Gloria Lau; Renato T Skerlj
Prospective CCR5 small molecule antagonist compound design using a combined mutagenesis/modeling approach.
Jean Labrecque; Markus Metz; Gloria Lau; Marilyn C Darkes; Rebecca S Y Wong; David Bogucki; Bryon Carpenter; Gang Chen; Tongshuang Li; Susan Nan; Dominique Schols; Gary J Bridger; Simon P Fricker; Renato T Skerlj
HIV-1 entry inhibition by small-molecule CCR5 antagonists: a combined molecular modeling and mutant study using a high-throughput assay.

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All Publications

2012: Renee Mosi; Kim L Nelson; Ketan Patel; Zefferino Santucci; Dominique Schols; Renato T Skerlj; Rebecca S Y Wong; Virginia Anastassova; Gary J Bridger; Jennifer Cox; Marilyn C Darkes; Dana Huskens; Stefan R Idzan; Jean Labrecque; Gloria Lau; Simon P Fricker
The molecular pharmacology of AMD11070: an orally bioavailable CXCR4 HIV entry inhibitor.
Biochemical pharmacology 2012;83(4):472-9.
2011: Markus Metz; Zefferino Santucci; Dominique Schols; Wen Yang; Elyse Bourque; Gary J Bridger; Sanjay J Danthi; Marilyn C Darkes; Simon P Fricker; Curtis Harwig; Jean Labrecque; Jonathan Langille; Gloria Lau; Renato T Skerlj
Prospective CCR5 small molecule antagonist compound design using a combined mutagenesis/modeling approach.
Journal of the American Chemical Society 2011;133(41):16477-85.
2011: Jean Labrecque; Markus Metz; Gloria Lau; Marilyn C Darkes; Rebecca S Y Wong; David Bogucki; Bryon Carpenter; Gang Chen; Tongshuang Li; Susan Nan; Dominique Schols; Gary J Bridger; Simon P Fricker; Renato T Skerlj
HIV-1 entry inhibition by small-molecule CCR5 antagonists: a combined molecular modeling and mutant study using a high-throughput assay.
Virology 2011;413(2):231-43.
2009: Veronique Bodart; Virginia Anastassov; Marilyn C Darkes; Stefan R Idzan; Jean Labrecque; Gloria Lau; Renee Mosi; Kathleen S Neff; Kim L Nelson; Melanie C Ruzek; Ketan Patel; Zefferino Santucci; Robert Scarborough; Rebecca S Y Wong; Gary J Bridger; Ron T Macfarland; Simon P Fricker
Pharmacology of AMD3465: a small molecule antagonist of the chemokine receptor CXCR4.
Biochemical pharmacology 2009;78(8):993-1000.
2006: Simon P Fricker; Virginia Anastassov; Jennifer Cox; Marilyn C Darkes; Ognjen Grujic; Stefan R Idzan; Jean Labrecque; Gloria Lau; Renee Mosi; Kim L Nelson; Ling Qin; Zeffy Santucci; Rebecca S Y Wong
Characterization of the molecular pharmacology of AMD3100: a specific antagonist of the G-protein coupled chemokine receptor, CXCR4.
Biochemical pharmacology 2006;72(5):588-96.
2005: Jean Labrecque; Virginia Anastassov; Gloria Lau; Marilyn C Darkes; Renee Mosi; Simon P Fricker
The development of an europium-GTP assay to quantitate chemokine antagonist interactions for CXCR4 and CCR5.
Assay and drug development technologies 2005;3(6):637-48.
2003: Beth Cameron; Marilyn C Darkes; Ian R Baird; Renato T Skerlj; Zefferino L Santucci; Simon P Fricker
Ruthenium(III) triazacyclononane dithiocarbamate, pyridinecarboxylate, or aminocarboxylate complexes as scavengers of nitric oxide.
Inorganic chemistry 2003;42(13):4102-8.
2003: Beth Cameron; Marilyn C Darkes; Helen Yee; Micki Olsen; Simon P Fricker; Renato T Skerlj; Gary J Bridger; Nathan A Davies; Michael T Wilson; David J Rose; Jon Zubieta
Ruthenium(III) polyaminocarboxylate complexes: efficient and effective nitric oxide scavengers.
Inorganic chemistry 2003;42(6):1868-76.
2003: Irvin Mayers; Thomas Hurst; Anna Radomski; David Johnson; Simon P Fricker; Gary J Bridger; Beth Cameron; Marilyn C Darkes; Marek W Radomski
Increased matrix metalloproteinase activity after canine cardiopulmonary bypass is suppressed by a nitric oxide scavenger.
The Journal of thoracic and cardiovascular surgery 2003;125(3):661-8.
2002: Renee Mosi; B Seguin; Beth Cameron; L Amankwa; Marilyn C Darkes; Simon P Fricker
Mechanistic studies on AMD6221: a ruthenium-based nitric oxide scavenger.
Biochemical and biophysical research communications 2002;292(2):519-29.
2002: Galen M Pieper; Allan M Roza; Mark B Adams; Gail Hilton; Mary Johnson; Christopher C Felix; Bal Kampalath; Marilyn C Darkes; Yangsheng Wanggui; Beth Cameron; Simon P Fricker
A ruthenium (III) polyaminocarboxylate complex, a novel nitric oxide scavenger, enhances graft survival and decreases nitrosylated heme protein in models of acute and delayed cardiac transplant rejection.
Journal of cardiovascular pharmacology 2002;39(3):441-8.
1999: R C Brooks; Paul Carnochan; J F Vollano; NA Powell; J Zweit; J K Sosabowski; S Martellucci; Marilyn C Darkes; Simon P Fricker; B A Murrer
Metal complexes of bleomycin: evaluation of [Rh-105]-bleomycin for use in targeted radiotherapy.
Nuclear medicine and biology 1999;26(4):421-30.