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Gretchen Darlington

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Yanjun Jiang; Jingling Jin; Angela Mayor; David Moore; Vladislav Sharin; Emily Sullivan; Sayee Anakk; Gretchen Darlington; Milton Finegold; Il-Hwa Hong; Polina Iakova; Nikolai A Timchenko
Farnesoid X receptor inhibits gankyrin in mouse livers and prevents development of liver cancer.
Jingling Jin; Guo-Li Wang; Xiurong Shi; Gretchen Darlington; Nikolai A Timchenko
The age-associated decline of glycogen synthase kinase 3beta plays a critical role in the inhibition of liver regeneration.
Hashem B El-Serag; Zhannat Z Nurgalieva; Toni-Ann Mistretta; Milton J Finegold; Rhonda Souza; Susan Hilsenbeck; Chad Shaw; Gretchen Darlington
Gene expression in Barrett's esophagus: laser capture versus whole tissue.

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All Publications

2013: Yanjun Jiang; Jingling Jin; Angela Mayor; David Moore; Vladislav Sharin; Emily Sullivan; Sayee Anakk; Gretchen Darlington; Milton Finegold; Il-Hwa Hong; Polina Iakova; Nikolai A Timchenko
Farnesoid X receptor inhibits gankyrin in mouse livers and prevents development of liver cancer.
Hepatology (Baltimore, Md.) 2013;57(3):1098-106.
2009: Jingling Jin; Guo-Li Wang; Xiurong Shi; Gretchen Darlington; Nikolai A Timchenko
The age-associated decline of glycogen synthase kinase 3beta plays a critical role in the inhibition of liver regeneration.
Molecular and cellular biology 2009;29(14):3867-80.
2009: Hashem B El-Serag; Zhannat Z Nurgalieva; Toni-Ann Mistretta; Milton J Finegold; Rhonda Souza; Susan Hilsenbeck; Chad Shaw; Gretchen Darlington
Gene expression in Barrett's esophagus: laser capture versus whole tissue.
Scandinavian journal of gastroenterology 2009;44(7):787-95.
2008: Pallavi Singh; Zeynep Z Coskun; Catriona Goode; Adam Dean; LuAnn Thompson-Snipes; Gretchen Darlington
Lymphoid neogenesis and immune infiltration in aged liver.
Hepatology (Baltimore, Md.) 2008;47(5):1680-90.
2007: Anilkumar K Reddy; Daniel Amador-Noguez; Gretchen Darlington; Beth A Scholz; Lloyd H Michael; Craig J Hartley; Mark L Entman; George E Taffet
Cardiac function in young and old Little mice.
The journals of gerontology. Series A, Biological sciences and medical sciences 2007;62(12):1319-25.
2007: Scott A Ochsner; Hélène Strick-Marchand; Qiong Qiu; Susan Venable; Adam Dean; Margie Wilde; Mary C Weiss; Gretchen Darlington
Transcriptional profiling of bipotential embryonic liver cells to identify liver progenitor cell surface markers.
Stem cells (Dayton, Ohio) 2007;25(10):2476-87.
2007: Daniel Amador-Noguez; Adam Dean; Wendong Huang; Kenneth Setchell; David Moore; Gretchen Darlington
Alterations in xenobiotic metabolism in the long-lived Little mice.
Aging cell 2007;6(4):453-70.
2006: Teresa V Bowman; Andrew J McCooey; Akil A Merchant; Carlos A Ramos; Patricia Fonseca; Alan Poindexter; Steven B Bradfute; Daniela M Oliveira; Rahshaana Green; Yayun Zheng; Kathyjo A Jackson; Stuart M Chambers; Shannon L McKinney-Freeman; Kevin Norwood; Gretchen Darlington; Preethi H Gunaratne; David Steffen; Margaret A Goodell
Differential mRNA processing in hematopoietic stem cells.
Stem cells (Dayton, Ohio) 2006;24(3):662-70.
2005: Jianqi Yang; Colleen Croniger; Julie Lekstrom-Himes; Pu Zhang; Maris L Fenyus; Daniel G Tenen; Gretchen Darlington; Richard W Hanson
Metabolic response of mice to a postnatal ablation of CCAAT/enhancer-binding protein alpha.
The Journal of biological chemistry 2005;280(46):38689-99.
2005: Steven abrams; Ian Griffin; Keli M Hawthorne; Lily Liang; Sheila K Gunn; Gretchen Darlington; Kenneth J Ellis
A combination of prebiotic short- and long-chain inulin-type fructans enhances calcium absorption and bone mineralization in young adolescents.
The American journal of clinical nutrition 2005;82(2):471-6.
2005: Daniel Amador-Noguez; John Zimmerman; Susan Venable; Gretchen Darlington
Gender-specific alterations in gene expression and loss of liver sexual dimorphism in the long-lived Ames dwarf mice.
Biochemical and biophysical research communications 2005;332(4):1086-100.
2005: Steven abrams; Ian Griffin; Keli M Hawthorne; Zhensheng Chen; Sheila K Gunn; Margaret Wilde; Gretchen Darlington; Roman Shypailo; Kenneth J Ellis
Vitamin D receptor Fok1 polymorphisms affect calcium absorption, kinetics, and bone mineralization rates during puberty.
Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research 2005;20(6):945-53.
2004: Daniel Amador-Noguez; Kazuo Yagi; Susan Venable; Gretchen Darlington
Gene expression profile of long-lived Ames dwarf mice and Little mice.
Aging cell 2004;3(6):423-41.
2004: Stephanie L Mackey; Gretchen Darlington
CCAAT enhancer-binding protein alpha is required for interleukin-6 receptor alpha signaling in newborn hepatocytes.
The Journal of biological chemistry 2004;279(16):16206-13.
2003: Patricia L Ramsay; Z Luo; A Major; MS Park; Milton Finegold; Stephen E Welty; Inseok Kwak; Gretchen Darlington; Francesco J DeMayo
Multiple mechanisms for oxygen-induced regulation of the Clara cell secretory protein gene.
FASEB journal : official publication of the Federation of American Societies for Experimental Biology 2003;17(14):2142-4.
2002: Alana L Welm; Nikolai A Timchenko; Yasuko Ono; Hiroyuki Sorimachi; Hannah S Radomska; Daniel G Tenen; Julie Lekstrom-Himes; Gretchen Darlington
C/EBPalpha is required for proteolytic cleavage of cyclin A by calpain 3 in myeloid precursor cells.
The Journal of biological chemistry 2002;277(37):33848-56.
2001: T E Harris; Jeffrey H Albrecht; M Nakanishi; Gretchen Darlington
CCAAT/enhancer-binding protein-alpha cooperates with p21 to inhibit cyclin-dependent kinase-2 activity and induces growth arrest independent of DNA binding.
The Journal of biological chemistry 2001;276(31):29200-9.
2000: Alana L Welm; Stephanie L Mackey; Lubov T Timchenko; Gretchen Darlington; Nikolai A Timchenko
Translational induction of liver-enriched transcriptional inhibitory protein during acute phase response leads to repression of CCAAT/enhancer binding protein alpha mRNA.
The Journal of biological chemistry 2000;275(35):27406-13.
1999: Gretchen Darlington
Molecular mechanisms of liver development and differentiation.
Current opinion in cell biology 1999;11(6):678-82.
1999: Vladimir I Khaoustov; Gretchen Darlington; HE Soriano; Bhuvaneswari Krishnan; Diana Risin; Neal R Pellis; Boris Yoffe
Induction of three-dimensional assembly of human liver cells by simulated microgravity.
In vitro cellular & developmental biology. Animal 1999;35(9):501-9.
1999: Nikolai A Timchenko; Margie Wilde; Polina Iakova; Jeffrey H Albrecht; Gretchen Darlington
E2F/p107 and E2F/p130 complexes are regulated by C/EBPalpha in 3T3-L1 adipocytes.
Nucleic acids research 1999;27(17):3621-30.
1999: Nikolai A Timchenko; Margie Wilde; Gretchen Darlington
C/EBPalpha regulates formation of S-phase-specific E2F-p107 complexes in livers of newborn mice.
Molecular and cellular biology 1999;19(4):2936-45.
1999: Alana L Welm; Nikolai A Timchenko; Gretchen Darlington
C/EBPalpha regulates generation of C/EBPbeta isoforms through activation of specific proteolytic cleavage.
Molecular and cellular biology 1999;19(3):1695-704.
1999: BL Burgess-Beusse; Nikolai A Timchenko; Gretchen Darlington
CCAAT/enhancer binding protein alpha (C/EBPalpha) is an important mediator of mouse C/EBPbeta protein isoform production.
Hepatology (Baltimore, Md.) 1999;29(2):597-601.
1999: Boris Yoffe; Gretchen Darlington; HE Soriano; Bhuvaneswari Krishnan; Diana Risin; Neal R Pellis; Vladimir I Khaoustov
Cultures of human liver cells in simulated microgravity environment.
Advances in space research : the official journal of the Committee on Space Research (COSPAR) 1999;24(6):829-36.
1998: BL Burgess-Beusse; Gretchen Darlington
C/EBPalpha is critical for the neonatal acute-phase response to inflammation.
Molecular and cellular biology 1998;18(12):7269-77.
1998: Gretchen Darlington; Sarah E Ross; Ormond A MacDougald
The role of C/EBP genes in adipocyte differentiation.
The Journal of biological chemistry 1998;273(46):30057-60.
1998: Vincent M Christoffels; Thierry Grange; Klaus kaestner; T J Cole; Gretchen Darlington; Colleen Croniger; Wouter H Lamers
Glucocorticoid receptor, C/EBP, HNF3, and protein kinase A coordinately activate the glucocorticoid response unit of the carbamoylphosphate synthetase I gene.
Molecular and cellular biology 1998;18(11):6305-15.
1998: Nikolai A Timchenko; Margie Wilde; KI Kosai; Ahmad R Heydari; TA Bilyeu; Milton J Finegold; K Mohamedali; Arlan G Richardson; Gretchen Darlington
Regenerating livers of old rats contain high levels of C/EBPalpha that correlate with altered expression of cell cycle associated proteins.
Nucleic acids research 1998;26(13):3293-9.
1998: Tiffany N. Seagroves; S Krnacik; B Raught; J Gay; BL Burgess-Beusse; Gretchen Darlington; Jeffrey M Rosen
C/EBPbeta, but not C/EBPalpha, is essential for ductal morphogenesis, lobuloalveolar proliferation, and functional differentiation in the mouse mammary gland.
Genes & development 1998;12(12):1917-28.
1998: KI Kosai; Milton J Finegold; B T Thi-Huynh; M Tewson; Ching-Nan Ou; N Bowles; SL Woo; R H Schwall; Gretchen Darlington
Retrovirus-mediated in vivo gene transfer in the replicating liver using recombinant hepatocyte growth factor without liver injury or partial hepatectomy.
Human gene therapy 1998;9(9):1293-301.
1998: Thomas J Oesterreicher; L L Leeper; Milton J Finegold; Gretchen Darlington; Susan J Henning
Intestinal maturation in mice lacking CCAAT/enhancer-binding protein alpha (C/EPBalpha).
The Biochemical journal 1998;330 ( Pt 3)():1165-71.
1998: HE Soriano; D C Kang; Milton J Finegold; M J Hicks; N D Wang; Wilbur Harrison; Gretchen Darlington
Lack of C/EBP alpha gene expression results in increased DNA synthesis and an increased frequency of immortalization of freshly isolated mice [correction of rat] hepatocytes.
Hepatology (Baltimore, Md.) 1998;27(2):392-401.
1997: Nikolai A Timchenko; T E Harris; Margie Wilde; TA Bilyeu; BL Burgess-Beusse; Milton J Finegold; Gretchen Darlington
CCAAT/enhancer binding protein alpha regulates p21 protein and hepatocyte proliferation in newborn mice.
Molecular and cellular biology 1997;17(12):7353-61.
1997: Colleen Croniger; Michael Trus; K Lysek-Stupp; Hannah Cohen; Yu Liu; Gretchen Darlington; Valeria Poli; Richard W Hanson; Lea Reshef
Role of the isoforms of CCAAT/enhancer-binding protein in the initiation of phosphoenolpyruvate carboxykinase (GTP) gene transcription at birth.
The Journal of biological chemistry 1997;272(42):26306-12.
1997: Ivica Rubelj; Susan Venable; John A Lednicky; Janet S Butel; TA Bilyeu; Gretchen Darlington; Eva Surmacz; J Campisi; Olivia M Pereira-Smith
Loss of T-antigen sequences allows SV40-transformed human cells in crisis to acquire a senescent-like phenotype.
The journals of gerontology. Series A, Biological sciences and medical sciences 1997;52(5):B229-34.
1997: Dong-Er Zhang; P Zhang; N D Wang; Christopher J Hetherington; Gretchen Darlington; Daniel G Tenen
Absence of granulocyte colony-stimulating factor signaling and neutrophil development in CCAAT enhancer binding protein alpha-deficient mice.
Proceedings of the National Academy of Sciences of the United States of America 1997;94(2):569-74.
1996: S E Nizielski; P S Lechner; Colleen Croniger; N D Wang; Gretchen Darlington; Richard W Hanson
Animal models for studying the genetic basis of metabolic regulation.
The Journal of nutrition 1996;126(11):2697-708.
1996: A Ozer; Vladimir I Khaoustov; M Mearns; D E Lewis; Robert Genta; Gretchen Darlington; Boris Yoffe
Effect of hepatocyte proliferation and cellular DNA synthesis on hepatitis B virus replication.
Gastroenterology 1996;110(5):1519-28.
1996: Nikolai A Timchenko; Margie Wilde; M Nakanishi; James R Smith; Gretchen Darlington
CCAAT/enhancer-binding protein alpha (C/EBP alpha) inhibits cell proliferation through the p21 (WAF-1/CIP-1/SDI-1) protein.
Genes & development 1996;10(7):804-15.
1995: L R Hendricks-Taylor; Gretchen Darlington
Inhibition of cell proliferation by C/EBP alpha occurs in many cell types, does not require the presence of p53 or Rb, and is not affected by large T-antigen.
Nucleic acids research 1995;23(22):4726-33.
1995: Gretchen Darlington; N Wang; R W Hanson
C/EBP alpha: a critical regulator of genes governing integrative metabolic processes.
Current opinion in genetics & development 1995;5(5):565-70.
1995: HE Soriano; T A Bilyeu; T S Juan; W Zhao; Gretchen Darlington
DNA binding by C/EBP proteins correlates with hepatocyte proliferation.
In vitro cellular & developmental biology. Animal 1995;31(9):703-9.
1995: N D Wang; M J Finegold; Allan Bradley; C N Ou; S V Abdelsayed; Margie Wilde; L R Taylor; D R Wilson; Gretchen Darlington
Impaired energy homeostasis in C/EBP alpha knockout mice.
Science (New York, N.Y.) 1995;269(5227):1108-12.
1995: Nikolai A Timchenko; D R Wilson; L R Taylor; S Abdelsayed; Margie Wilde; M Sawadogo; Gretchen Darlington
Autoregulation of the human C/EBP alpha gene by stimulation of upstream stimulatory factor binding.
Molecular and cellular biology 1995;15(3):1192-202.
1994: K J Wu; D R Wilson; C Shih; Gretchen Darlington
The transcription factor HNF1 acts with C/EBP alpha to synergistically activate the human albumin promoter through a novel domain.
The Journal of biological chemistry 1994;269(2):1177-82.
1993: T S Juan; D R Wilson; Margie Wilde; Gretchen Darlington
Participation of the transcription factor C/EBP delta in the acute-phase regulation of the human gene for complement component C3.
Proceedings of the National Academy of Sciences of the United States of America 1993;90(7):2584-8.
1992: F D Ledley; HE Soriano; Bert W O'Malley; D Lewis; Gretchen Darlington; Milton Finegold
DiI as a marker for cellular transplantation into solid organs.
BioTechniques 1992;13(4):580, 582, 584-7.
1992: L R Hendricks-Taylor; Linda L Bachinski; M J Siciliano; A Fertitta; Barbara J Trask; P J de Jong; David Ledbetter; Gretchen Darlington
The CCAAT/enhancer binding protein (C/EBP alpha) gene (CEBPA) maps to human chromosome 19q13.1 and the related nuclear factor NF-IL6 (C/EBP beta) gene (CEBPB) maps to human chromosome 20q13.1.
Genomics 1992;14(1):12-7.
1991: K J Wu; Linda C Samuelson; G Howard; Miriam H Meisler; Gretchen Darlington
Transactivation of pancreas-specific gene sequences in somatic cell hybrids.
Molecular and cellular biology 1991;11(9):4423-30.
1991: K P Ponder; R P Dunbar; D R Wilson; Gretchen Darlington; SL Woo
Evaluation of relative promoter strength in primary hepatocytes using optimized lipofection.
Human gene therapy 1991;2(1):41-52.
1991: F D Ledley; SL Woo; G D Ferry; H H Whisennand; Mary L Brandt; Gretchen Darlington; Gail J Demmler; M J Finegold; W J Pokorny; Howard M Rosenblatt
Hepatocellular transplantation in acute hepatic failure and targeting genetic markers to hepatic cells.
Human gene therapy 1991;2(4):331-58.
1990: D R Wilson; T S Juan; Margie Wilde; Georg H Fey; Gretchen Darlington
A 58-base-pair region of the human C3 gene confers synergistic inducibility by interleukin-1 and interleukin-6.
Molecular and cellular biology 1990;10(12):6181-91.
1989: J H Kelly; Gretchen Darlington
Modulation of the liver specific phenotype in the human hepatoblastoma line Hep G2.
In vitro cellular & developmental biology : journal of the Tissue Culture Association 1989;25(2):217-22.
1989: Gretchen Darlington; D R Wilson; M Revel; J H Kelly
Response of liver genes to acute phase mediators.
Annals of the New York Academy of Sciences 1989;557():310-5; discussion 315-6.