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Jean-Luc Darlix

Research Profile

Living Beings

HIV-1
Virion

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Publications

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Clément Monot; Sébastien Viollet; Jean-Luc Darlix; Caroline Gabus; Monika Kuciak; Ashfaq Ali Mir; Gaël Cristofari
The specificity and flexibility of l1 reverse transcription priming at imperfect T-tracts.
Nancy Beerens; Jean-Luc Darlix; Mette D E Jepsen; Jørgen Kjems; Asger C Krüger; Volodymyr Nechyporuk-Zloy; Victoria Birkedal
Role of the primer activation signal in tRNA annealing onto the HIV-1 genome studied by single-molecule FRET microscopy.
Gilles Mirambeau; Michael Summers; Jean-Luc Darlix; Ben Berkhout
Foreword to the virus research special issue on "retroviral RNA, protein co-factors and chaperones".

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All Publications

2013: Clément Monot; Sébastien Viollet; Jean-Luc Darlix; Caroline Gabus; Monika Kuciak; Ashfaq Ali Mir; Gaël Cristofari
The specificity and flexibility of l1 reverse transcription priming at imperfect T-tracts.
PLoS genetics 2013;9(5):e1003499.
2013: Nancy Beerens; Jean-Luc Darlix; Mette D E Jepsen; Jørgen Kjems; Asger C Krüger; Volodymyr Nechyporuk-Zloy; Victoria Birkedal
Role of the primer activation signal in tRNA annealing onto the HIV-1 genome studied by single-molecule FRET microscopy.
RNA (New York, N.Y.) 2013;19(4):517-26.
2012: Gilles Mirambeau; Michael Summers; Jean-Luc Darlix; Ben Berkhout
Foreword to the virus research special issue on "retroviral RNA, protein co-factors and chaperones".
Virus research 2012;169(2):322-3.
2012: Roland Ivanyi-Nagy; Jean-Luc Darlix
Reprint of: Core protein-mediated 5'-3' annealing of the West Nile virus genomic RNA in vitro.
Virus research 2012;169(2):448-57.
2012: Julien Godet; Nicolas Humbert; Roland Ivanyi-Nagy; Christian Boudier; Jean-Luc Darlix; Yves Mély
Comparative nucleic acid chaperone properties of the nucleocapsid protein NCp7 and Tat protein of HIV-1.
Virus research 2012;169(2):349-60.
2012: Julien Batisse; Serena Bernacchi; Jean-Luc Darlix; Caroline Gabus; Santiago Guerrero; Roland Marquet; Dona Sleiman; Carine Tisné; Jean-Christophe Paillart
The role of Vif oligomerization and RNA chaperone activity in HIV-1 replication.
Virus research 2012;169(2):361-76.
2012: Roland Ivanyi-Nagy; Jean-Luc Darlix
Core protein-mediated 5'-3' annealing of the West Nile virus genomic RNA in vitro.
Virus research 2012;167(2):226-35.
2012: Sandrine Alais; Vincent Balter; Andrea Cimarelli; Jean-Luc Darlix; Gruffat Henri; Evelyne Manet; Théophile Ohlmann; Graça Raposo; Laurent Schaeffer; Ricardo Soto-Rifo; Pascal Leblanc
Functional mechanisms of the cellular prion protein (PrP(C)) associated anti-HIV-1 properties.
Cellular and molecular life sciences : CMLS 2012;69(8):1331-52.
2012: Kamal Kant Sharma; François Pénin; Jean-Luc Darlix; Hugues de Rocquigny; Jean-Pierre Lavergne; Jean-Marc Lessinger; Yves Mély
Analysis of the RNA chaperoning activity of the hepatitis C virus core protein on the conserved 3'X region of the viral genome.
Nucleic acids research 2012;40(6):2540-53.
2012: Jorge Vera-Otarola; Jean-Luc Darlix; Théophile Ohlmann; Karla Pino; Emiliano P Ricci; Loretto Solis; Ricardo Soto-Rifo; Nicole D Tischler; Marcelo Lopez-Lastra
The Andes hantavirus NSs protein is expressed from the viral small mRNA by a leaky scanning mechanism.
Journal of virology 2012;86(4):2176-87.
2012: Sergiy V Avilov; Christian Boudier; Jean-Luc Darlix; Marina Gottikh; Yves Mély
Characterization of the inhibition mechanism of HIV-1 nucleocapsid protein chaperone activities by methylated oligoribonucleotides.
Antimicrobial agents and chemotherapy 2012;56(2):1010-8.
2012: Olivier Liard; Melissa Cambon; Jean-Luc Darlix; Thierry Fusai; André Nau; Aurélie Pascual; Emmanuel Sagui; Stéphanie Segura; Emmanuel Moyse
Adult-brain-derived neural stem cells grafting into a vein bridge increases postlesional recovery and regeneration in a peripheral nerve of adult pig.
Stem cells international 2012;2012():128732.
2012: Roland Ivanyi-Nagy; Jean-Luc Darlix
Fuzziness in the core of the human pathogenic viruses HCV and HIV.
Advances in experimental medicine and biology 2012;725():142-58.
2012: Kathy R Chaurasiya; Gaël Cristofari; Jean-Luc Darlix; Hylkje Geertsema; Mark C Williams
A single zinc finger optimizes the DNA interactions of the nucleocapsid protein of the yeast retrotransposon Ty3.
Nucleic acids research 2012;40(2):751-60.
2011: Vincent Caval; Jean-Luc Darlix; Roland Ivanyi-Nagy; Eric Piver; Jean-Christophe Pagès
Packaging of HCV-RNA into lentiviral vector.
Biochemical and biophysical research communications 2011;414(4):808-13.
2011: Cécile Guichard; Roland Ivanyi-Nagy; Daniel Marc; Yves Mély; Kamal Kant Sharma; Caroline Gabus; Jean-Luc Darlix
Analysis of nucleic acid chaperoning by the prion protein and its inhibition by oligonucleotides.
Nucleic acids research 2011;39(19):8544-58.
2011: Igor Kanevsky; Olivier Mauffret; Yves Mély; Brigitte RENE; Françoise Chaminade; Yingying Chen; Jean-Luc Darlix; Julien Godet; Philippe Fossé
Structural determinants of TAR RNA-DNA annealing in the absence and presence of HIV-1 nucleocapsid protein.
Nucleic acids research 2011;39(18):8148-62.
2011: Gregory Berger; Serge Bouaziz; Stéphanie Cordeil; Jean-Luc Darlix; Stéphanie Durand; Guillaume Fargier; Delphine Muriaux; Xuan-Nhi Nguyen; Andrea Cimarelli
APOBEC3A is a specific inhibitor of the early phases of HIV-1 infection in myeloid cells.
PLoS pathogens 2011;7(9):e1002221.
2011: Julien Godet; Jean-Luc Darlix; Hugues de Rocquigny; Guy Duportail; Nick Ramalanjaona; Ludovic Richert; Kamal K Sharma; Yves Mély
Specific implications of the HIV-1 nucleocapsid zinc fingers in the annealing of the primer binding site complementary sequences during the obligatory plus strand transfer.
Nucleic acids research 2011;39(15):6633-45.
2011: Jean-Luc Darlix; Philippe Fossé; Julien Godet; Roland Ivanyi-Nagy; Olivier Mauffret; Yves Mély
Flexible nature and specific functions of the HIV-1 nucleocapsid protein.
Journal of molecular biology 2011;410(4):565-81.
2011: Boyan Grigorov; Yves Mély; Myriam Witvrouw; Gilles Divita; Caroline Gabus; Marina Gottikh; Audrey Agopian; Sergey Avilov; Anne Bocquin; Jean-Luc Darlix
Identification of a methylated oligoribonucleotide as a potent inhibitor of HIV-1 reverse transcription complex.
Nucleic acids research 2011;39(13):5586-96.
2011: Grégory Berger; Stéphanie Durand; Caroline Goujon; Xuan-Nhi Nguyen; Stéphanie Cordeil; Jean-Luc Darlix; Andrea Cimarelli
A simple, versatile and efficient method to genetically modify human monocyte-derived dendritic cells with HIV-1-derived lentiviral vectors.
Nature protocols 2011;6(6):806-16.
2010: Delphine Muriaux; Jean-Luc Darlix
Properties and functions of the nucleocapsid protein in virus assembly.
RNA biology 2010;7(6):744-53.
2010: Jorge Vera-Otarola; Ricardo Soto-Rifo; Emiliano P Ricci; Théophile Ohlmann; Jean-Luc Darlix; Marcelo Lopez-Lastra
The 3' untranslated region of the Andes hantavirus small mRNA functionally replaces the poly(A) tail and stimulates cap-dependent translation initiation from the viral mRNA.
Journal of virology 2010;84(19):10420-4.
2010: Nicolás Cifuentes-Muñoz; Jean-Luc Darlix; Nicole D Tischler
Development of a lentiviral vector system to study the role of the Andes virus glycoproteins.
Virus research 2010;153(1):29-35.
2010: Roland Ivanyi-Nagy; Jean-Luc Darlix
Intrinsic disorder in the core proteins of flaviviruses.
Protein and peptide letters 2010;17(8):1019-25.
2010: Christian Boudier; R Storchak; K K Sharma; P Didier; Anny Follenius-Wund; Sylviane Muller; Jean-Luc Darlix; Yves Mély
The mechanism of HIV-1 Tat-directed nucleic acid annealing supports its role in reverse transcription.
Journal of molecular biology 2010;400(3):487-501.
2010: Kamal kant Sharma; Pascal Didier; Jean-Luc Darlix; Hugues de Rocquigny; Hayet Bensikaddour; Jean-Pierre Lavergne; François Pénin; Jean-Marc Lessinger; Yves Mély
Kinetic analysis of the nucleic acid chaperone activity of the hepatitis C virus core protein.
Nucleic acids research 2010;38(11):3632-42.
2010: Marylene MOUGEL; Andrea Cimarelli; Jean-Luc Darlix
Implications of the nucleocapsid and the microenvironment in retroviral reverse transcription.
Viruses 2010;2(4):939-60.
2010: Joëlle V Fritz; Denis Dujardin; Julien Godet; Pascal Didier; Jan De Mey; Jean-Luc Darlix; Yves Mély; Hugues de Rocquigny
HIV-1 Vpr oligomerization but not that of Gag directs the interaction between Vpr and Gag.
Journal of virology 2010;84(3):1585-96.
2010: Lise Rivière; Jean-Luc Darlix; Andrea Cimarelli
Analysis of the viral elements required in the nuclear import of HIV-1 DNA.
Journal of virology 2010;84(2):729-39.
2009: Vanessa Arfi; Julia Lienard; Xuan-Nhi Nguyen; Gregory Berger; Dominique Rigal; Jean-Luc Darlix; Andrea Cimarelli
Characterization of the behavior of functional viral genomes during the early steps of human immunodeficiency virus type 1 infection.
Journal of virology 2009;83(15):7524-35.
2009: Nicolas Charnay; Roland Ivanyi-Nagy; Ricardo Soto-Rifo; Théophile Ohlmann; Marcelo Lopez-Lastra; Jean-Luc Darlix
Mechanism of HIV-1 Tat RNA translation and its activation by the Tat protein.
Retrovirology 2009;6():74.
2009: Boyan Grigorov; Valérie Attuil-Audenis; Fabien Perugi; Martine Nedelec; Sarah Watson; Claudine Pique; Jean-Luc Darlix; HELENE CONJEAUD; Delphine Muriaux
A role for CD81 on the late steps of HIV-1 replication in a chronically infected T cell line.
Retrovirology 2009;6():28.
2009: Marylene MOUGEL; Laurent Houzet; Jean-Luc Darlix
When is it time for reverse transcription to start and go?
Retrovirology 2009;6():24.
2009: Fabien Perugi; Delphine Muriaux; Bertha Cecilia Ramirez; Sabah Chabani; Etienne Decroly; Jean-Luc Darlix; Vincent Blot; Claudine Pique
Human Discs Large is a new negative regulator of human immunodeficiency virus-1 infectivity.
Molecular biology of the cell 2009;20(1):498-508.
2009: G Berger; C Goujon; Jean-Luc Darlix; Andrea Cimarelli
SIVMAC Vpx improves the transduction of dendritic cells with nonintegrative HIV-1-derived vectors.
Gene therapy 2009;16(1):159-63.
2008: Caroline Goujon; Vanessa Arfi; Thomas Pertel; Jeremy Luban; Julia Lienard; Dominique Rigal; Jean-Luc Darlix; Andrea Cimarelli
Characterization of simian immunodeficiency virus SIVSM/human immunodeficiency virus type 2 Vpx function in human myeloid cells.
Journal of virology 2008;82(24):12335-45.
2008: Dina Grohmann; Julien Godet; Yves Mély; Jean-Luc Darlix; Tobias Restle
HIV-1 nucleocapsid traps reverse transcriptase on nucleic acid substrates.
Biochemistry 2008;47(46):12230-40.
2008: Berta Bosch; Boyan Grigorov; Jordi Senserrich; Bonaventura Clotet; Jean-Luc Darlix; Delphine Muriaux; José A Este
A clathrin-dynamin-dependent endocytic pathway for the uptake of HIV-1 by direct T cell-T cell transmission.
Antiviral research 2008;80(2):185-93.
2008: Sandrine Alais; Sabrina Simoes; Dominique Baas; Sylvain Lehmann; Graça Raposo; Jean-Luc Darlix; Pascal LEBLANC
Mouse neuroblastoma cells release prion infectivity associated with exosomal vesicles.
Biology of the cell / under the auspices of the European Cell Biology Organization 2008;100(10):603-15.
2008: Ludovic Didierlaurent; Laurent Houzet; Zakia Morichaud; Jean-Luc Darlix; Marylene MOUGEL
The conserved N-terminal basic residues and zinc-finger motifs of HIV-1 nucleocapsid restrict the viral cDNA synthesis during virus formation and maturation.
Nucleic acids research 2008;36(14):4745-53.
2008: Emiliano P Ricci; Cécile H Herbreteau; Didier Decimo; Andreas Schaupp; Siddhartha A K Datta; Alan Rein; Jean-Luc Darlix; Théophile Ohlmann
In vitro expression of the HIV-2 genomic RNA is controlled by three distinct internal ribosome entry segments that are regulated by the HIV protease and the Gag polyprotein.
RNA (New York, N.Y.) 2008;14(7):1443-55.
2008: Vanessa Arfi; Lise Rivière; Loraine Jarrosson-Wuillème; Caroline Goujon; Dominique Rigal; Jean-Luc Darlix; Andrea Cimarelli
Characterization of the early steps of infection of primary blood monocytes by human immunodeficiency virus type 1.
Journal of virology 2008;82(13):6557-65.
2008: Monika Kuciak; Caroline Gabus; Roland Ivanyi-Nagy; Katharina Semrad; Roman Storchak; Olivier Chaloin; Sylviane Muller; Yves Mély; Jean-Luc Darlix
The HIV-1 transcriptional activator Tat has potent nucleic acid chaperoning activities in vitro.
Nucleic acids research 2008;36(10):3389-400.
2008: Laurent Houzet; Zakia Morichaud; Ludovic Didierlaurent; Delphine Muriaux; Jean-Luc Darlix; Marylene MOUGEL
Nucleocapsid mutations turn HIV-1 into a DNA-containing virus.
Nucleic acids research 2008;36(7):2311-9.
2008: Valentina Camerini; Didier Decimo; Laurent Balvay; Mauro Pistello; Mauro Bendinelli; Jean-Luc Darlix; Théophile Ohlmann
A dormant internal ribosome entry site controls translation of feline immunodeficiency virus.
Journal of virology 2008;82(7):3574-83.
2008: Roland Ivanyi-Nagy; Jean-Pierre Lavergne; Caroline Gabus; Damien Ficheux; Jean-Luc Darlix
RNA chaperoning and intrinsic disorder in the core proteins of Flaviviridae.
Nucleic acids research 2008;36(3):712-25.
2008: Joëlle V Fritz; Pascal Didier; Jean-Pierre Clamme; Emmanuel Schaub; Delphine Muriaux; Charlotte Cabanne; Nelly Morellet; Serge Bouaziz; Jean-Luc Darlix; Yves Mély; Hugues de Rocquigny
Direct Vpr-Vpr interaction in cells monitored by two photon fluorescence correlation spectroscopy and fluorescence lifetime imaging.
Retrovirology 2008;5():87.
2008: Ben Berkhout; Robert Gorelick; Michael F Summers; Yves Mély; Jean-Luc Darlix
6th international symposium on retroviral nucleocapsid.
Retrovirology 2008;5():21.
2008: Hugues de Rocquigny; Volodymyr V Shvadchak; Sergiy V Avilov; Chang-Zhi Dong; Ursula Dietrich; Jean-Luc Darlix; Yves Mély
Targeting the viral nucleocapsid protein in anti-HIV-1 therapy.
Mini reviews in medicinal chemistry 2008;8(1):24-35.
2008: Antoine Corbin; Boyan Grigorov; Philippe Roingeard; Jean-Luc Darlix; Delphine Muriaux
[Revisiting HIV-1 assembly].
Médecine sciences : M/S 2008;24(1):49-55.
2008: Jean-Luc Darlix; Yves Lévy
[AIDS virus in the middle of the ford twenty-five years later].
Médecine sciences : M/S 2008;24(1):4-6.
2007: Caroline Egelé; Etienne Piémont; Pascal Didier; Damien Ficheux; Bernard Roques; Jean-Luc Darlix; Hugues de Rocquigny; Yves Mély
The single-finger nucleocapsid protein of moloney murine leukemia virus binds and destabilizes the TAR sequences of HIV-1 but does not promote efficiently their annealing.
Biochemistry 2007;46(50):14650-62.
2007: Nick Ramalanjaona; Hugues de Rocquigny; Aurélie Millet; Damien Ficheux; Jean-Luc Darlix; Yves Mély
Investigating the mechanism of the nucleocapsid protein chaperoning of the second strand transfer during HIV-1 DNA synthesis.
Journal of molecular biology 2007;374(4):1041-53.
2007: Moez Ben Ali; Françoise Chaminade; Igor Kanevsky; Vincent Olieric; Laurence Josset; Damien Ficheux; Jean-Luc Darlix; Philippe Fossé
Structural requirements for nucleocapsid protein-mediated dimerization of avian leukosis virus RNA.
Journal of molecular biology 2007;372(4):1082-96.
2007: Dong Sung An; Robert E Donahue; masakazu kamata; Betty Poon; Mark Metzger; Si-Hua Mao; Aylin Bonifacino; Allen Krouse; Jean-Luc Darlix; David Baltimore; F Xiao-Feng Qin; Irvin S Y Chen
Stable reduction of CCR5 by RNAi through hematopoietic stem cell transplant in non-human primates.
Proceedings of the National Academy of Sciences of the United States of America 2007;104(32):13110-5.
2007: Jean-Luc Darlix; Marc Sitbon
[Prostate cancer leads to the discovery of a new human infectious retrovirus].
Médecine sciences : M/S 2007;23(8-9):690-1.
2007: Laurent Balvay; Marcelo Lopez-Lastra; Bruno Sargueil; Jean-Luc Darlix; Théophile Ohlmann
Translational control of retroviruses.
Nature reviews. Microbiology 2007;5(2):128-40.
2007: Boyan Grigorov; Didier Décimo; Fatima Smagulova; Christine Péchoux; Marylene MOUGEL; Delphine Muriaux; Jean-Luc Darlix
Intracellular HIV-1 Gag localization is impaired by mutations in the nucleocapsid zinc fingers.
Retrovirology 2007;4():54.
2007: Jean-Luc Darlix; José Luis Garrido; Nelly Morellet; Yves Mély; Hugues de Rocquigny
Properties, functions, and drug targeting of the multifunctional nucleocapsid protein of the human immunodeficiency virus.
Advances in pharmacology (San Diego, Calif.) 2007;55():299-346.
2007: Dina Rakotobe; Jean-Claude Tardy; Patrice André; Saw See Hong; Jean-Luc Darlix; Pierre Boulanger
Human Polycomb group EED protein negatively affects HIV-1 assembly and release.
Retrovirology 2007;4():37.
2007: Anne Gatignol; Jean Dubuisson; Mark A Wainberg; Eric A Cohen; Jean-Luc Darlix
New pandemics: HIV and AIDS, HCV and chronic hepatitis, influenza virus and flu.
Retrovirology 2007;4():8.
2007: Caroline Goujon; Lise Rivière; Loraine Jarrosson-Wuilleme; Janine Bernaud; Dominique Rigal; Jean-Luc Darlix; Andrea Cimarelli
SIVSM/HIV-2 Vpx proteins promote retroviral escape from a proteasome-dependent restriction pathway present in human dendritic cells.
Retrovirology 2007;4():2.
2006: Chinappan Raja; Jan Ferner; Ursula Dietrich; Sergiy Avilov; Damien Ficheux; Jean-Luc Darlix; Hugues de Rocquigny; Harald Schwalbe; Yves Mély
A tryptophan-rich hexapeptide inhibits nucleic acid destabilization chaperoned by the HIV-1 nucleocapsid protein.
Biochemistry 2006;45(30):9254-65.
2006: Pascal LEBLANC; Sandrine Alais; Isabel Porto-Carreiro; Sylvain Lehmann; Jacques Grassi; Graça Raposo; Jean-Luc Darlix
Retrovirus infection strongly enhances scrapie infectivity release in cell culture.
The EMBO journal 2006;25(12):2674-85.
2006: Boyan Grigorov; Fabienne Arcanger; Philippe Roingeard; Jean-Luc Darlix; Delphine Muriaux
Assembly of infectious HIV-1 in human epithelial and T-lymphoblastic cell lines.
Journal of molecular biology 2006;359(4):848-62.
2006: Caroline Goujon; L Jarrosson-Wuillème; Janine Bernaud; Dominique Rigal; Jean-Luc Darlix; Andrea Cimarelli
With a little help from a friend: increasing HIV transduction of monocyte-derived dendritic cells with virion-like particles of SIV(MAC).
Gene therapy 2006;13(12):991-4.
2006: Carole Bampi; Arkadiusz Bibillo; Michaela Wendeler; Gilles Divita; Robert J Gorelick; Stuart F J Le Grice; Jean-Luc Darlix
Nucleotide excision repair and template-independent addition by HIV-1 reverse transcriptase in the presence of nucleocapsid protein.
The Journal of biological chemistry 2006;281(17):11736-43.
2006: Julien Godet; Hugues de Rocquigny; Chinnappan Raja; Nicole Glasser; Damien Ficheux; Jean-Luc Darlix; Yves Mély
During the early phase of HIV-1 DNA synthesis, nucleocapsid protein directs hybridization of the TAR complementary sequences via the ends of their double-stranded stem.
Journal of molecular biology 2006;356(5):1180-92.
2006: Loraine Jarrosson-Wuilleme; Caroline Goujon; Janine Bernaud; Dominique Rigal; Jean-Luc Darlix; Andrea Cimarelli
Transduction of nondividing human macrophages with gammaretrovirus-derived vectors.
Journal of virology 2006;80(3):1152-9.
2006: Caroline Gabus; Roland Ivanyi-Nagy; Julien Depollier; Alain Bucheton; Alain Pelisson; Jean-Luc Darlix
Characterization of a nucleocapsid-like region and of two distinct primer tRNALys,2 binding sites in the endogenous retrovirus Gypsy.
Nucleic acids research 2006;34(20):5764-77.
2006: Roland Ivanyi-Nagy; Igor Kanevsky; Caroline Gabus; Jean-Pierre Lavergne; Damien Ficheux; François Penin; Philippe Fossé; Jean-Luc Darlix
Analysis of hepatitis C virus RNA dimerization and core-RNA interactions.
Nucleic acids research 2006;34(9):2618-33.
2005: Cécile H Herbreteau; Laure Weill; Didier Décimo; Déborah Prévôt; Jean-Luc Darlix; Bruno Sargueil; Théophile Ohlmann
HIV-2 genomic RNA contains a novel type of IRES located downstream of its initiation codon.
Nature structural & molecular biology 2005;12(11):1001-7.
2005: Berta Bosch; Julià Blanco; Eduardo Pauls; Imma Clotet-Codina; Mercedes Armand-Ugón; Boyan Grigorov; Delphine Muriaux; Bonaventura Clotet; Jean-Luc Darlix; José A Esté
Inhibition of coreceptor-independent cell-to-cell human immunodeficiency virus type 1 transmission by a CD4-immunoglobulin G2 fusion protein.
Antimicrobial agents and chemotherapy 2005;49(10):4296-304.
2005: Roland Ivanyi-Nagy; Laetitia Davidovic; Edouard W Khandjian; Jean-Luc Darlix
Disordered RNA chaperone proteins: from functions to disease.
Cellular and molecular life sciences : CMLS 2005;62(13):1409-17.
2005: Hervé Beltz; Céline Clauss; Etienne Piémont; Damien Ficheux; Robert J Gorelick; Bernard P Roques; Caroline Gabus; Jean-Luc Darlix; Hugues de Rocquigny; Yves Mély
Structural determinants of HIV-1 nucleocapsid protein for cTAR DNA binding and destabilization, and correlation with inhibition of self-primed DNA synthesis.
Journal of molecular biology 2005;348(5):1113-26.
2005: Igor Kanevsky; Françoise Chaminade; Damien Ficheux; Abdeladim Moumen; Robert J Gorelick; Matteo Negroni; Jean-Luc Darlix; Philippe Fossé
Specific interactions between HIV-1 nucleocapsid protein and the TAR element.
Journal of molecular biology 2005;348(5):1059-77.
2005: Hervé Perron; Françoise Lazarini; Klemens Ruprecht; Christine Péchoux-Longin; Danielle Seilhean; Véronique Sazdovitch; Alain Créange; Nicole Battail-Poirot; Geneviève Sibaï; Lyse Santoro; Michel Jolivet; Jean-Luc Darlix; Peter Rieckmann; Thomas Arzberger; JEAN-JACQUES HAUW; Hans Lassmann
Human endogenous retrovirus (HERV)-W ENV and GAG proteins: physiological expression in human brain and pathophysiological modulation in multiple sclerosis lesions.
Journal of neurovirology 2005;11(1):23-33.
2005: Edmund A Derrington; Marcelo Lopez-Lastra; Jean-Luc Darlix
Dicistronic MLV-retroviral vectors transduce neural precursors in vivo and co-express two genes in their differentiated neuronal progeny.
Retrovirology 2005;2():60.
2005: Sandrine Jacquenet; Didier Decimo; Delphine Muriaux; Jean-Luc Darlix
Dual effect of the SR proteins ASF/SF2, SC35 and 9G8 on HIV-1 RNA splicing and virion production.
Retrovirology 2005;2():33.
2004: Caroline Egelé; Emmanuel Schaub; Nick Ramalanjaona; Etienne Piémont; Damien Ficheux; Bernard P Roques; Jean-Luc Darlix; Yves Mély
HIV-1 nucleocapsid protein binds to the viral DNA initiation sequences and chaperones their kissing interactions.
Journal of molecular biology 2004;342(2):453-66.
2004: Carole Bampi; Sandrine Jacquenet; Daniela Lener; Didier Décimo; Jean-Luc Darlix
The chaperoning and assistance roles of the HIV-1 nucleocapsid protein in proviral DNA synthesis and maintenance.
The international journal of biochemistry & cell biology 2004;36(9):1668-86.
2004: Virginie Sandrin; Delphine Muriaux; Jean-Luc Darlix; François-Loïc Cosset
Intracellular trafficking of Gag and Env proteins and their interactions modulate pseudotyping of retroviruses.
Journal of virology 2004;78(13):7153-64.
2004: Hervé Beltz; Etienne Piémont; Emmanuel Schaub; Damien Ficheux; Bernard P Roques; Jean-Luc Darlix; Yves Mély
Role of the structure of the top half of HIV-1 cTAR DNA on the nucleic acid destabilizing activity of the nucleocapsid protein NCp7.
Journal of molecular biology 2004;338(4):711-23.
2004: Pascal LEBLANC; Dominique Baas; Jean-Luc Darlix
Analysis of the interactions between HIV-1 and the cellular prion protein in a human cell line.
Journal of molecular biology 2004;337(4):1035-51.
2004: Corinne Ronfort; Sylvain de Breyne; Virginie Sandrin; Jean-Luc Darlix; Théophile Ohlmann
Characterization of two distinct RNA domains that regulate translation of the Drosophila gypsy retroelement.
RNA (New York, N.Y.) 2004;10(3):504-15.
2004: Delphine Muriaux; Jean-Luc Darlix; Andrea Cimarelli
Targeting the assembly of the human immunodeficiency virus type I.
Current pharmaceutical design 2004;10(30):3725-39.
2004: Gael Cristofari; Roland Ivanyi-Nagy; Caroline Gabus; Steeve Boulant; Jean-Pierre Lavergne; François Penin; Jean-Luc Darlix
The hepatitis C virus Core protein is a potent nucleic acid chaperone that directs dimerization of the viral (+) strand RNA in vitro.
Nucleic acids research 2004;32(8):2623-31.
2004: Caroline Gabus; Rachid Mazroui; Sandra Tremblay; Edouard W Khandjian; Jean-Luc Darlix
The fragile X mental retardation protein has nucleic acid chaperone properties.
Nucleic acids research 2004;32(7):2129-37.
2004: Carole Bampi; Sandrine Jacquenet; Daniela Lener; Didier Décimo; Jean-Luc Darlix
The chaperoning and assistance roles of the HIV-1 nucleocapsid protein in proviral DNA synthesis and maintenance.
Current HIV research 2004;2(1):79-92.
2003: Guruswamy Krishnamoorthy; Bernard P Roques; Jean-Luc Darlix; Yves Mély
DNA condensation by the nucleocapsid protein of HIV-1: a mechanism ensuring DNA protection.
Nucleic acids research 2003;31(18):5425-32.
2003: Caroline Goujon; Loraine Jarrosson-Wuilleme; Janine Bernaud; Dominique Rigal; Jean-Luc Darlix; Andrea Cimarelli
Heterologous human immunodeficiency virus type 1 lentiviral vectors packaging a simian immunodeficiency virus-derived genome display a specific postentry transduction defect in dendritic cells.
Journal of virology 2003;77(17):9295-304.
2003: Leonora Poljak; Susan M Batson; Damien Ficheux; Bernard P Roques; Jean-Luc Darlix; Emmanuel Käs
Analysis of NCp7-dependent activation of HIV-1 cDNA integration and its conservation among retroviral nucleocapsid proteins.
Journal of molecular biology 2003;329(3):411-21.
2003: Déborah Prévôt; Jean-Luc Darlix; Théophile Ohlmann
Conducting the initiation of protein synthesis: the role of eIF4G.
Biology of the cell / under the auspices of the European Cell Biology Organization 2003;95(3-4):141-56.
2003: Hervé Beltz; Joel Azoulay; Serena Bernacchi; Jean-Pierre Clamme; Damien Ficheux; Bernard P Roques; Jean-Luc Darlix; Yves Mély
Impact of the terminal bulges of HIV-1 cTAR DNA on its stability and the destabilizing activity of the nucleocapsid protein NCp7.
Journal of molecular biology 2003;328(1):95-108.
2003: Déborah Prévôt; Didier Décimo; Cécile H Herbreteau; Florence Roux; Jérôme Garin; Jean-Luc Darlix; Théophile Ohlmann
Characterization of a novel RNA-binding region of eIF4GI critical for ribosomal scanning.
The EMBO journal 2003;22(8):1909-21.
2003: Ann Brasey; Marcelo Lopez-Lastra; Théophile Ohlmann; Nancy Beerens; Ben Berkhout; Jean-Luc Darlix; Nahum Sonenberg
The leader of human immunodeficiency virus type 1 genomic RNA harbors an internal ribosome entry segment that is active during the G2/M phase of the cell cycle.
Journal of virology 2003;77(7):3939-49.
2003: Jérôme Jullien; Vincent Guili; Edmund A Derrington; Jean-Luc Darlix; Louis F Reichardt; Brian B Rudkin
Trafficking of TrkA-green fluorescent protein chimerae during nerve growth factor-induced differentiation.
The Journal of biological chemistry 2003;278(10):8706-16.
2003: Joel Azoulay; Jean-Pierre Clamme; Jean-Luc Darlix; Bernard P Roques; Yves Mély
Destabilization of the HIV-1 complementary sequence of TAR by the nucleocapsid protein through activation of conformational fluctuations.
Journal of molecular biology 2003;326(3):691-700.
2002: Gael Cristofari; Carole Bampi; Marcelle Wilhelm; François-Xavier Wilhelm; Jean-Luc Darlix
A 5'-3' long-range interaction in Ty1 RNA controls its reverse transcription and retrotransposition.
The EMBO journal 2002;21(16):4368-79.
2002: Andrea Cimarelli; Jean-Luc Darlix
Assembling the human immunodeficiency virus type 1.
Cellular and molecular life sciences : CMLS 2002;59(7):1166-84.
2002: Mila Moscardini; Mauro Pistello; Mauro Bendinelli; Damien Ficheux; Jennifer T Miller; Caroline Gabus; Stuart F J Le Grice; Witold K Surewicz; Jean-Luc Darlix
Functional interactions of nucleocapsid protein of feline immunodeficiency virus and cellular prion protein with the viral RNA.
Journal of molecular biology 2002;318(1):149-59.
2002: Théophile Ohlmann; Déborah Prévôt; Didier Décimo; Florence Roux; Jérôme Garin; Simon J Morley; Jean-Luc Darlix
In vitro cleavage of eIF4GI but not eIF4GII by HIV-1 protease and its effects on translation in the rabbit reticulocyte lysate system.
Journal of molecular biology 2002;318(1):9-20.
2002: Serena Bernacchi; Stoyl Stoylov; Etienne Piémont; Damien Ficheux; Bernard P Roques; Jean-Luc Darlix; Yves Mély
HIV-1 nucleocapsid protein activates transient melting of least stable parts of the secondary structure of TAR and its complementary sequence.
Journal of molecular biology 2002;317(3):385-99.
2002: Philippe-Emmanuel Mangeot; Karine Duperrier; Didier Nègre; Bertrand Boson; Dominique Rigal; François-Loïc Cosset; Jean-Luc Darlix
High levels of transduction of human dendritic cells with optimized SIV vectors.
Molecular therapy : the journal of the American Society of Gene Therapy 2002;5(3):283-90.
2002: M Henrietta Nymark-McMahon; Nadejda Beliakova-Bethell; Jean-Luc Darlix; Stuart F J Le Grice; Suzanne Sandmeyer
Ty3 integrase is required for initiation of reverse transcription.
Journal of virology 2002;76(6):2804-16.
2002: Gael Cristofari; Jean-Luc Darlix
The ubiquitous nature of RNA chaperone proteins.
Progress in nucleic acid research and molecular biology 2002;72():223-68.
2002: Didier Nègre; Ghislaine Duisit; Philippe-Emmanuel Mangeot; Philippe Moullier; Jean-Luc Darlix; François-Loïc Cosset
Lentiviral vectors derived from simian immunodeficiency virus.
Current topics in microbiology and immunology 2002;261():53-74.
2002: Edmund A Derrington; Caroline Gabus; Pascal LEBLANC; Jonas Chnaidermann; Linda Grave; Dominique Dormont; Wieslaw Swietnicki; MANUEL MORILLAS; Daniel Marck; Pradip Nandi; Jean-Luc Darlix
PrPC has nucleic acid chaperoning properties similar to the nucleocapsid protein of HIV-1.
Comptes rendus biologies 2002;325(1):17-23.
2001: Isabelle Franceschini; V Feigenbaum-Lacombe; Philippe Casanova; Marcelo Lopez-Lastra; Jean-Luc Darlix; M D Dalcq
Efficient gene transfer in mouse neural precursors with a bicistronic retroviral vector.
Journal of neuroscience research 2001;65(3):208-19.
2001: Caroline Gabus; Edmund A Derrington; Pascal LEBLANC; J Chnaiderman; Dominique Dormont; Wieslaw Swietnicki; MANUEL MORILLAS; Witold K Surewicz; D Marc; Pradip Nandi; Jean-Luc Darlix
The prion protein has RNA binding and chaperoning properties characteristic of nucleocapsid protein NCP7 of HIV-1.
The Journal of biological chemistry 2001;276(22):19301-9.
2001: Caroline Gabus; S Auxilien; Christine Péchoux; Dominique Dormont; Wieslaw Swietnicki; MANUEL MORILLAS; Witold K Surewicz; Pradip Nandi; Jean-Luc Darlix
The prion protein has DNA strand transfer properties similar to retroviral nucleocapsid protein.
Journal of molecular biology 2001;307(4):1011-21.
2001: Michael Laughrea; N Shen; L Jetté; Jean-Luc Darlix; Lawrence Kleiman; Mark A Wainberg
Role of distal zinc finger of nucleocapsid protein in genomic RNA dimerization of human immunodeficiency virus type 1; no role for the palindrome crowning the R-U5 hairpin.
Virology 2001;281(1):109-16.
2000: Didier Nègre; Philippe-Emmanuel Mangeot; Ghislaine Duisit; S Blanchard; Pierre-Olivier Vidalain; Philippe Leissner; A J Winter; Chantal Rabourdin-Combe; Majid Mehtali; Philippe Moullier; Jean-Luc Darlix; François-Loïc Cosset
Characterization of novel safe lentiviral vectors derived from simian immunodeficiency virus (SIVmac251) that efficiently transduce mature human dendritic cells.
Gene therapy 2000;7(19):1613-23.
2000: Philippe-Emmanuel Mangeot; Didier Nègre; B Dubois; A J Winter; Philippe Leissner; Majid Mehtali; D Kaiserlian; François-Loïc Cosset; Jean-Luc Darlix
Development of minimal lentivirus vectors derived from simian immunodeficiency virus (SIVmac251) and their use for gene transfer into human dendritic cells.
Journal of virology 2000;74(18):8307-15.
2000: E Polge; Jean-Luc Darlix; J Paoletti; Philippe Fossé
Characterization of loose and tight dimer forms of avian leukosis virus RNA.
Journal of molecular biology 2000;300(1):41-56.
2000: Gael Cristofari; Damien Ficheux; Jean-Luc Darlix
The GAG-like protein of the yeast Ty1 retrotransposon contains a nucleic acid chaperone domain analogous to retroviral nucleocapsid proteins.
The Journal of biological chemistry 2000;275(25):19210-7.
2000: Théophile Ohlmann; Marcelo Lopez-Lastra; Jean-Luc Darlix
An internal ribosome entry segment promotes translation of the simian immunodeficiency virus genomic RNA.
The Journal of biological chemistry 2000;275(16):11899-906.
2000: Jean-Luc Darlix; Gael Cristofari; M Rau; Christine Péchoux; L Berthoux; B Roques
Nucleocapsid protein of human immunodeficiency virus as a model protein with chaperoning functions and as a target for antiviral drugs.
Advances in pharmacology (San Diego, Calif.) 2000;48():345-72.
1999: Gael Cristofari; Caroline Gabus; Damien Ficheux; Marion K Bona; Stuart F J Le Grice; Jean-Luc Darlix
Characterization of active reverse transcriptase and nucleoprotein complexes of the yeast retrotransposon Ty3 in vitro.
The Journal of biological chemistry 1999;274(51):36643-8.
1999: L Berthoux; Christine Péchoux; Jean-Luc Darlix
Multiple effects of an anti-human immunodeficiency virus nucleocapsid inhibitor on virus morphology and replication.
Journal of virology 1999;73(12):10000-9.
1999: Marcelo Lopez-Lastra; S Ulrici; Caroline Gabus; Jean-Luc Darlix
Identification of an internal ribosome entry segment in the 5' region of the mouse VL30 retrotransposon and its use in the development of retroviral vectors.
Journal of virology 1999;73(10):8393-402.
1999: Edmund A Derrington; Marcelo Lopez-Lastra; S Chapel-Fernandez; F L Cosset; Marie-Françoise Belin; Brian B Rudkin; Jean-Luc Darlix
Retroviral vectors for the expression of two genes in human multipotent neural precursors and their differentiated neuronal and glial progeny.
Human gene therapy 1999;10(7):1129-38.
1999: Shan Cen; Yue Huang; Ahmad Khorchid; Jean-Luc Darlix; Mark A Wainberg; Lawrence Kleiman
The role of Pr55(gag) in the annealing of tRNA3Lys to human immunodeficiency virus type 1 genomic RNA.
Journal of virology 1999;73(5):4485-8.
1998: Daniela Lener; V Tanchou; Bernard P Roques; Stuart F J Le Grice; Jean-Luc Darlix
Involvement of HIV-I nucleocapsid protein in the recruitment of reverse transcriptase into nucleoprotein complexes formed in vitro.
The Journal of biological chemistry 1998;273(50):33781-6.
1998: Q Yu; M Ottmann; C Pechoux; S Le Grice; Jean-Luc Darlix
Mutations in the primer grip of human immunodeficiency virus type 1 reverse transcriptase impair proviral DNA synthesis and virion maturation.
Journal of virology 1998;72(9):7676-80.
1998: Caroline Gabus; Damien Ficheux; M Rau; G Keith; Suzanne Sandmeyer; Jean-Luc Darlix
The yeast Ty3 retrotransposon contains a 5'-3' bipartite primer-binding site and encodes nucleocapsid protein NCp9 functionally homologous to HIV-1 NCp7.
The EMBO journal 1998;17(16):4873-80.
1998: J B Rascle; Damien Ficheux; Jean-Luc Darlix
Possible roles of nucleocapsid protein of MoMuLV in the specificity of proviral DNA synthesis and in the genetic variability of the virus.
Journal of molecular biology 1998;280(2):215-25.
1998: V Tanchou; Didier Decimo; Christine Péchoux; Daniela Lener; V Rogemond; L Berthoux; M Ottmann; Jean-Luc Darlix
Role of the N-terminal zinc finger of human immunodeficiency virus type 1 nucleocapsid protein in virus structure and replication.
Journal of virology 1998;72(5):4442-7.
1998: Yue Huang; Ahmad Khorchid; Juliana Gabor; J Wang; X Li; Jean-Luc Darlix; Mark A Wainberg; Lawrence Kleiman
The role of nucleocapsid and U5 stem/A-rich loop sequences in tRNA(3Lys) genomic placement and initiation of reverse transcription in human immunodeficiency virus type 1.
Journal of virology 1998;72(5):3907-15.
1998: B Allain; J B Rascle; Hugues de Rocquigny; Bernard P Roques; Jean-Luc Darlix
CIS elements and trans-acting factors required for minus strand DNA transfer during reverse transcription of the genomic RNA of murine leukemia virus.
Journal of molecular biology 1998;277(2):225-35.
1997: Hugues de Rocquigny; P Petitjean; V Tanchou; Didier Decimo; L Drouot; T Delaunay; Jean-Luc Darlix; Bernard P Roques
The zinc fingers of HIV nucleocapsid protein NCp7 direct interactions with the viral regulatory protein Vpr.
The Journal of biological chemistry 1997;272(49):30753-9.
1997: Marcelo Lopez-Lastra; Caroline Gabus; Jean-Luc Darlix
Characterization of an internal ribosomal entry segment within the 5' leader of avian reticuloendotheliosis virus type A RNA and development of novel MLV-REV-based retroviral vectors.
Human gene therapy 1997;8(16):1855-65.
1997: L Berthoux; Christine Péchoux; M Ottmann; G Morel; Jean-Luc Darlix
Mutations in the N-terminal domain of human immunodeficiency virus type 1 nucleocapsid protein affect virion core structure and proviral DNA synthesis.
Journal of virology 1997;71(9):6973-81.
1997: S Carteau; S C Batson; Leonora Poljak; Jean-François Mouscadet; Hugues de Rocquigny; Jean-Luc Darlix; Bernard P Roques; Emmanuel Käs; Christian Auclair
Human immunodeficiency virus type 1 nucleocapsid protein specifically stimulates Mg2+-dependent DNA integration in vitro.
Journal of virology 1997;71(8):6225-9.
1997: Yue Huang; Ahmad Khorchid; J Wang; Michael A Parniak; Jean-Luc Darlix; Mark A Wainberg; Lawrence Kleiman
Effect of mutations in the nucleocapsid protein (NCp7) upon Pr160(gag-pol) and tRNA(Lys) incorporation into human immunodeficiency virus type 1.
Journal of virology 1997;71(6):4378-84.
1997: M Lapadat-Tapolsky; Caroline Gabus; M Rau; Jean-Luc Darlix
Possible roles of HIV-1 nucleocapsid protein in the specificity of proviral DNA synthesis and in its variability.
Journal of molecular biology 1997;268(2):250-60.
1996: P Fossé; N Motté; Anne Roumier; Caroline Gabus; D Muriaux; Jean-Luc Darlix; J Paoletti
A short autocomplementary sequence plays an essential role in avian sarcoma-leukosis virus RNA dimerization.
Biochemistry 1996;35(51):16601-9.
1996: Jean-Christophe Paillart; L Berthoux; M Ottmann; Jean-Luc Darlix; Roland Marquet; Bernard Ehresmann; Chantal Ehresmann
A dual role of the putative RNA dimerization initiation site of human immunodeficiency virus type 1 in genomic RNA packaging and proviral DNA synthesis.
Journal of virology 1996;70(12):8348-54.
1996: Xiaodong Li; Yudong Quan; E J Arts; Z Li; B D Preston; Hugues de Rocquigny; Bernard P Roques; Jean-Luc Darlix; Lawrence Kleiman; M A Parniak; Mark A Wainberg
Human immunodeficiency virus Type 1 nucleocapsid protein (NCp7) directs specific initiation of minus-strand DNA synthesis primed by human tRNA(Lys3) in vitro: studies of viral RNA molecules mutated in regions that flank the primer binding site.
Journal of virology 1996;70(8):4996-5004.
1996: M Ghosh; P S Jacques; D W Rodgers; M Ottman; Jean-Luc Darlix; Stuart F J Le Grice
Alterations to the primer grip of p66 HIV-1 reverse transcriptase and their consequences for template-primer utilization.
Biochemistry 1996;35(26):8553-62.
1996: C Torrent; C Berlioz; Jean-Luc Darlix
Stable MLV-VL30 dicistronic retroviral vectors with a VL30 or MoMLV sequence promoting both packaging of genomic RNA and expression of the 3' cistron.
Human gene therapy 1996;7(5):603-12.
1996: V Housset; Jean-Luc Darlix
Mutations at the capsid-nucleocapsid cleavage site of gag polyprotein of Moloney murine leukemia virus abolish virus infectivity.
Comptes rendus de l'Académie des sciences. Série III, Sciences de la vie 1996;319(2):81-9.
1995: Jean-Luc Darlix; M Lapadat-Tapolsky; Hugues de Rocquigny; B P Roques
First glimpses at structure-function relationships of the nucleocapsid protein of retroviruses.
Journal of molecular biology 1995;254(4):523-37.
1995: V Tanchou; Caroline Gabus; V Rogemond; Jean-Luc Darlix
Formation of stable and functional HIV-1 nucleoprotein complexes in vitro.
Journal of molecular biology 1995;252(5):563-71.
1995: C Berlioz; C Torrent; Jean-Luc Darlix
An internal ribosomal entry signal in the rat VL30 region of the Harvey murine sarcoma virus leader and its use in dicistronic retroviral vectors.
Journal of virology 1995;69(10):6400-7.
1995: V Tanchou; T Delaunay; M Bodéus; Bernard P Roques; Jean-Luc Darlix; Richard Benarous
Conformational changes between human immunodeficiency virus type 1 nucleocapsid protein NCp7 and its precursor NCp15 as detected by anti-NCp7 monoclonal antibodies.
The Journal of general virology 1995;76 ( Pt 10)():2457-66.
1995: M Lapadat-Tapolsky; C Pernelle; C Borie; Jean-Luc Darlix
Analysis of the nucleic acid annealing activities of nucleocapsid protein from HIV-1.
Nucleic acids research 1995;23(13):2434-41.
1995: C Berlioz; Jean-Luc Darlix
An internal ribosomal entry mechanism promotes translation of murine leukemia virus gag polyprotein precursors.
Journal of virology 1995;69(4):2214-22.
1995: M Ottmann; Caroline Gabus; Jean-Luc Darlix
The central globular domain of the nucleocapsid protein of human immunodeficiency virus type 1 is critical for virion structure and infectivity.
Journal of virology 1995;69(3):1778-84.
1994: P S Jacques; Birgitta M Wöhrl; M Ottmann; Jean-Luc Darlix; Stuart F J Le Grice
Mutating the "primer grip" of p66 HIV-1 reverse transcriptase implicates tryptophan-229 in template-primer utilization.
The Journal of biological chemistry 1994;269(42):26472-8.
1994: H Déméné; C Z Dong; M Ottmann; M C Rouyez; N Jullian; Nelly Morellet; Y Mely; Jean-Luc Darlix; Marie-Claude Fournié-Zaluski; Sentob Saragosti
1H NMR structure and biological studies of the His23-->Cys mutant nucleocapsid protein of HIV-1 indicate that the conformation of the first zinc finger is critical for virus infectivity.
Biochemistry 1994;33(39):11707-16.
1994: V Tanchou; T Delaunay; Hugues de Rocquigny; M Bodeus; Jean-Luc Darlix; Bernard P Roques; Richard Benarous
Monoclonal antibody-mediated inhibition of RNA binding and annealing activities of HIV type 1 nucleocapsid protein.
AIDS research and human retroviruses 1994;10(8):983-93.
1994: C Torrent; T Bordet; Jean-Luc Darlix
Analytical study of rat retrotransposon VL30 RNA dimerization in vitro and packaging in murine leukemia virus.
Journal of molecular biology 1994;240(5):434-44.
1994: A Corbin; Anne-Catherine Prats; Jean-Luc Darlix; M Sitbon
A nonstructural gag-encoded glycoprotein precursor is necessary for efficient spreading and pathogenesis of murine leukemia viruses.
Journal of virology 1994;68(6):3857-67.
1994: B Allain; M Lapadat-Tapolsky; C Berlioz; Jean-Luc Darlix
Transactivation of the minus-strand DNA transfer by nucleocapsid protein during reverse transcription of the retroviral genome.
The EMBO journal 1994;13(4):973-81.
1994: C Torrent; Caroline Gabus; Jean-Luc Darlix
A small and efficient dimerization/packaging signal of rat VL30 RNA and its use in murine leukemia virus-VL30-derived vectors for gene transfer.
Journal of virology 1994;68(2):661-7.
1994: Nelly Morellet; Hugues de Rocquigny; Yves Mély; N Jullian; H Déméné; M Ottmann; Dominique Gérard; Jean-Luc Darlix; MC Fournie-Zaluski; Bernard P Roques
Conformational behaviour of the active and inactive forms of the nucleocapsid NCp7 of HIV-1 studied by 1H NMR.
Journal of molecular biology 1994;235(1):287-301.
1993: Marylene MOUGEL; N Tounekti; Jean-Luc Darlix; J Paoletti; Bernard Ehresmann; Chantal Ehresmann
Conformational analysis of the 5' leader and the gag initiation site of Mo-MuLV RNA and allosteric transitions induced by dimerization.
Nucleic acids research 1993;21(20):4677-84.
1993: E Bieth; Jean-Luc Darlix
Characterization of a molecular clone of a highly infectious avian leukosis virus.
Comptes rendus de l'Académie des sciences. Série III, Sciences de la vie 1993;316(8):754-62.
1993: Jean-Luc Darlix; A Vincent; Caroline Gabus; Hugues de Rocquigny; B Roques
Trans-activation of the 5' to 3' viral DNA strand transfer by nucleocapsid protein during reverse transcription of HIV1 RNA.
Comptes rendus de l'Académie des sciences. Série III, Sciences de la vie 1993;316(8):763-71.
1993: C Barat; O Schatz; S Le Grice; Jean-Luc Darlix
Analysis of the interactions of HIV1 replication primer tRNA(Lys,3) with nucleocapsid protein and reverse transcriptase.
Journal of molecular biology 1993;231(2):185-90.
1993: V Housset; H De Rocquigny; B P Roques; Jean-Luc Darlix
Basic amino acids flanking the zinc finger of Moloney murine leukemia virus nucleocapsid protein NCp10 are critical for virus infectivity.
Journal of virology 1993;67(5):2537-45.
1993: Hugues de Rocquigny; Damien Ficheux; Caroline Gabus; B Allain; MC Fournie-Zaluski; Jean-Luc Darlix; Bernard P Roques
Two short basic sequences surrounding the zinc finger of nucleocapsid protein NCp10 of Moloney murine leukemia virus are critical for RNA annealing activity.
Nucleic acids research 1993;21(4):823-9.
1993: M Lapadat-Tapolsky; Hugues de Rocquigny; D Van Gent; B Roques; Ronald H Plasterk; Jean-Luc Darlix
Interactions between HIV-1 nucleocapsid protein and viral DNA may have important functions in the viral life cycle.
Nucleic acids research 1993;21(4):831-9.
1993: F Baudin; Roland Marquet; Catherine Isel; Jean-Luc Darlix; Bernard Ehresmann; Chantal Ehresmann
Functional sites in the 5' region of human immunodeficiency virus type 1 RNA form defined structural domains.
Journal of molecular biology 1993;229(2):382-97.
1992: Jean-Luc Darlix; Caroline Gabus; B Allain
Analytical study of avian reticuloendotheliosis virus dimeric RNA generated in vivo and in vitro.
Journal of virology 1992;66(12):7245-52.
1992: Nelly Morellet; N Jullian; Hugues de Rocquigny; Bernard Maigret; Jean-Luc Darlix; Bernard P Roques
Determination of the structure of the nucleocapsid protein NCp7 from the human immunodeficiency virus type 1 by 1H NMR.
The EMBO journal 1992;11(8):3059-65.
1992: Hugues de Rocquigny; Caroline Gabus; A Vincent; Marie-Claude Fournié-Zaluski; Bernard P Roques; Jean-Luc Darlix
Viral RNA annealing activities of human immunodeficiency virus type 1 nucleocapsid protein require only peptide domains outside the zinc fingers.
Proceedings of the National Academy of Sciences of the United States of America 1992;89(14):6472-6.
1992: H Lederer; O Schatz; R May; H Crespi; Jean-Luc Darlix; S F Le Grice; Hermann Heumann
Domain structure of the human immunodeficiency virus reverse transcriptase.
The EMBO journal 1992;11(3):1131-9.
1992: E Bieth; Jean-Luc Darlix
Complete nucleotide sequence of a highly infectious avian leukosis virus.
Nucleic acids research 1992;20(2):367.
1992: N Tounekti; Marylene MOUGEL; C Roy; Roland Marquet; Jean-Luc Darlix; J Paoletti; Bernard Ehresmann; Chantal Ehresmann
Effect of dimerization on the conformation of the encapsidation Psi domain of Moloney murine leukemia virus RNA.
Journal of molecular biology 1992;223(1):205-20.
1992: C Torrent; P Wang; Jean-Luc Darlix
A murine leukemia virus derived retroviral vector with a rat VL30 packaging psi sequence.
Bone marrow transplantation 1992;9 Suppl 1():143-7.
1991: Stuart F J Le Grice; M Panin; R C Kalayjian; Nancy J Richter; G Keith; Jean-Luc Darlix; Susan L Payne
Purification and characterization of recombinant equine infectious anemia virus reverse transcriptase.
Journal of virology 1991;65(12):7004-7.
1991: Hugues de Rocquigny; Damien Ficheux; Caroline Gabus; Marie-Claude Fournié-Zaluski; Jean-Luc Darlix; Bernard P Roques
First large scale chemical synthesis of the 72 amino acid HIV-1 nucleocapsid protein NCp7 in an active form.
Biochemical and biophysical research communications 1991;180(2):1010-8.
1991: Anne-Catherine Prats; V Housset; G de Billy; F Cornille; Hervé Prats; B Roques; Jean-Luc Darlix
Viral RNA annealing activities of the nucleocapsid protein of Moloney murine leukemia virus are zinc independent.
Nucleic acids research 1991;19(13):3533-41.
1991: Y Mely; F Cornille; Marie-Claude Fournié-Zaluski; Jean-Luc Darlix; Bernard P Roques; Dominique Gérard
Investigation of zinc-binding affinities of Moloney murine leukemia virus nucleocapsid protein and its related zinc finger and modified peptides.
Biopolymers 1991;31(7):899-906.
1991: Roland Marquet; F Baudin; Caroline Gabus; Jean-Luc Darlix; Marylene MOUGEL; Chantal Ehresmann; Bernard Ehresmann
Dimerization of human immunodeficiency virus (type 1) RNA: stimulation by cations and possible mechanism.
Nucleic acids research 1991;19(9):2349-57.
1991: C Barat; S F Le Grice; Jean-Luc Darlix
Interaction of HIV-1 reverse transcriptase with a synthetic form of its replication primer, tRNA(Lys,3).
Nucleic acids research 1991;19(4):751-7.
1990: C Roy; N Tounekti; Marylene MOUGEL; Jean-Luc Darlix; C Paoletti; Chantal Ehresmann; Bernard Ehresmann; J Paoletti
An analytical study of the dimerization of in vitro generated RNA of Moloney murine leukemia virus MoMuLV.
Nucleic acids research 1990;18(24):7287-92.
1990: Jean-Luc Darlix; Caroline Gabus; Marie-Thérèse Nugeyre; F Clavel; F Barré-Sinoussi
Cis elements and trans-acting factors involved in the RNA dimerization of the human immunodeficiency virus HIV-1.
Journal of molecular biology 1990;216(3):689-99.
1990: F Cornille; Y Mely; Damien Ficheux; I Savignol; D Gerard; Jean-Luc Darlix; MC Fournie-Zaluski; Bernard P Roques
Solid phase synthesis of the retroviral nucleocapsid protein NCp10 of Moloney murine leukaemia virus and related "zinc-fingers" in free SH forms. Influence of zinc chelation on structural and biochemical properties.
International journal of peptide and protein research 1990;36(6):551-8.
1990: Anne-Catherine Prats; C Roy; P A Wang; M Erard; V Housset; Caroline Gabus; C Paoletti; Jean-Luc Darlix
cis elements and trans-acting factors involved in dimer formation of murine leukemia virus RNA.
Journal of virology 1990;64(2):774-83.
1990: E Bieth; Caroline Gabus; Jean-Luc Darlix
A study of the dimer formation of Rous sarcoma virus RNA and of its effect on viral protein synthesis in vitro.
Nucleic acids research 1990;18(1):119-27.
1989: C Barat; V Lullien; O Schatz; G Keith; Marie-Thérèse Nugeyre; F Grüninger-Leitch; F Barré-Sinoussi; S F LeGrice; Jean-Luc Darlix
HIV-1 reverse transcriptase specifically interacts with the anticodon domain of its cognate primer tRNA.
The EMBO journal 1989;8(11):3279-85.
1989: Anne-Catherine Prats; G De Billy; P Wang; Jean-Luc Darlix
CUG initiation codon used for the synthesis of a cell surface antigen coded by the murine leukemia virus.
Journal of molecular biology 1989;205(2):363-72.
1988: Anne-Catherine Prats; L Sarih; Caroline Gabus; Simon Litvak; G Keith; Jean-Luc Darlix
Small finger protein of avian and murine retroviruses has nucleic acid annealing activity and positions the replication primer tRNA onto genomic RNA.
The EMBO journal 1988;7(6):1777-83.