Jean-Luc Darlix

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Arfi Vanessa; Lienard Julia; Nguyen Xuan-Nhi; Berger Gregory; Rigal Dominique; Darlix Jean-Luc; Cimarelli Andrea
Characterization of the behavior of functional viral genomes during the early steps of human immunodeficiency virus type 1 infection.
Perugi Fabien; Muriaux Delphine; Ramirez Bertha Cecilia; Chabani Sabah; Decroly Etienne; Darlix Jean-Luc; Blot Vincent; Pique Claudine
Human Discs Large is a new negative regulator of human immunodeficiency virus-1 infectivity.
Berger G; Goujon C; Darlix J-L; Cimarelli A
SIVMAC Vpx improves the transduction of dendritic cells with nonintegrative HIV-1-derived vectors.

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All Publications

2009: Arfi Vanessa; Lienard Julia; Nguyen Xuan-Nhi; Berger Gregory; Rigal Dominique; Darlix Jean-Luc; Cimarelli Andrea
Characterization of the behavior of functional viral genomes during the early steps of human immunodeficiency virus type 1 infection.
Journal of virology 2009;83(15):7524-35.
2009: Perugi Fabien; Muriaux Delphine; Ramirez Bertha Cecilia; Chabani Sabah; Decroly Etienne; Darlix Jean-Luc; Blot Vincent; Pique Claudine
Human Discs Large is a new negative regulator of human immunodeficiency virus-1 infectivity.
Molecular biology of the cell 2009;20(1):498-508.
2009: Berger G; Goujon C; Darlix J-L; Cimarelli A
SIVMAC Vpx improves the transduction of dendritic cells with nonintegrative HIV-1-derived vectors.
Gene therapy 2009;16(1):159-63.
2009: Charnay Nicolas; Ivanyi-Nagy Roland; Soto-Rifo Ricardo; Ohlmann Théophile; López-Lastra Marcelo; Darlix Jean-Luc
Mechanism of HIV-1 Tat RNA translation and its activation by the Tat protein.
Retrovirology 2009;6():74.
2009: Grigorov Boyan; Attuil-Audenis Valérie; Perugi Fabien; Nedelec Martine; Watson Sarah; Pique Claudine; Darlix Jean-Luc; Conjeaud Hélène; Muriaux Delphine
A role for CD81 on the late steps of HIV-1 replication in a chronically infected T cell line.
Retrovirology 2009;6():28.
2009: Mougel Marylène; Houzet Laurent; Darlix Jean-Luc
When is it time for reverse transcription to start and go?
Retrovirology 2009;6():24.
2008: Goujon Caroline; Arfi Vanessa; Pertel Thomas; Luban Jeremy; Lienard Julia; Rigal Dominique; Darlix Jean-Luc; Cimarelli Andrea
Characterization of simian immunodeficiency virus SIVSM/human immunodeficiency virus type 2 Vpx function in human myeloid cells.
Journal of virology 2008;82(24):12335-45.
2008: Grohmann Dina; Godet Julien; Mély Yves; Darlix Jean-Luc; Restle Tobias
HIV-1 nucleocapsid traps reverse transcriptase on nucleic acid substrates.
Biochemistry 2008;47(46):12230-40.
2008: Bosch Berta; Grigorov Boyan; Senserrich Jordi; Clotet Bonaventura; Darlix Jean-Luc; Muriaux Delphine; Este José A
A clathrin-dynamin-dependent endocytic pathway for the uptake of HIV-1 by direct T cell-T cell transmission.
Antiviral research 2008;80(2):185-93.
2008: Alais Sandrine; Simoes Sabrina; Baas Dominique; Lehmann Sylvain; Raposo Graça; Darlix Jean Luc; Leblanc Pascal
Mouse neuroblastoma cells release prion infectivity associated with exosomal vesicles.
Biology of the cell / under the auspices of the European Cell Biology Organization 2008;100(10):603-15.
2008: Didierlaurent Ludovic; Houzet Laurent; Morichaud Zakia; Darlix Jean-Luc; Mougel Marylène
The conserved N-terminal basic residues and zinc-finger motifs of HIV-1 nucleocapsid restrict the viral cDNA synthesis during virus formation and maturation.
Nucleic acids research 2008;36(14):4745-53.
2008: Ricci Emiliano P; Herbreteau Cécile H; Decimo Didier; Schaupp Andreas; Datta Siddhartha A K; Rein Alan; Darlix Jean-Luc; Ohlmann Théophile
In vitro expression of the HIV-2 genomic RNA is controlled by three distinct internal ribosome entry segments that are regulated by the HIV protease and the Gag polyprotein.
RNA (New York, N.Y.) 2008;14(7):1443-55.
2008: Arfi Vanessa; Rivière Lise; Jarrosson-Wuillème Loraine; Goujon Caroline; Rigal Dominique; Darlix Jean-Luc; Cimarelli Andrea
Characterization of the early steps of infection of primary blood monocytes by human immunodeficiency virus type 1.
Journal of virology 2008;82(13):6557-65.
2008: Kuciak Monika; Gabus Caroline; Ivanyi-Nagy Roland; Semrad Katharina; Storchak Roman; Chaloin Olivier; Muller Sylviane; Mély Yves; Darlix Jean-Luc
The HIV-1 transcriptional activator Tat has potent nucleic acid chaperoning activities in vitro.
Nucleic acids research 2008;36(10):3389-400.
2008: Houzet Laurent; Morichaud Zakia; Didierlaurent Ludovic; Muriaux Delphine; Darlix Jean-Luc; Mougel Marylène
Nucleocapsid mutations turn HIV-1 into a DNA-containing virus.
Nucleic acids research 2008;36(7):2311-9.
2008: Camerini Valentina; Decimo Didier; Balvay Laurent; Pistello Mauro; Bendinelli Mauro; Darlix Jean-Luc; Ohlmann Théophile
A dormant internal ribosome entry site controls translation of feline immunodeficiency virus.
Journal of virology 2008;82(7):3574-83.
2008: Ivanyi-Nagy Roland; Lavergne Jean-Pierre; Gabus Caroline; Ficheux Damien; Darlix Jean-Luc
RNA chaperoning and intrinsic disorder in the core proteins of Flaviviridae.
Nucleic acids research 2008;36(3):712-25.
2008: de Rocquigny Hugues; Shvadchak Volodymyr; Avilov Sergiy; Dong Chang Zhi; Dietrich Ursula; Darlix Jean-Luc; Mély Yves
Targeting the viral nucleocapsid protein in anti-HIV-1 therapy.
Mini reviews in medicinal chemistry 2008;8(1):24-35.
2008: Corbin Antoine; Grigorov Boyan; Roingeard Philippe; Darlix Jean-Luc; Muriaux Delphine
[Revisiting HIV-1 assembly]
Médecine sciences : M/S 2008;24(1):49-55.
2008: Darlix Jean-Luc; Lévy Yves
[AIDS virus in the middle of the ford twenty-five years later]
Médecine sciences : M/S 2008;24(1):4-6.
2008: Fritz Joëlle V; Didier Pascal; Clamme Jean-Pierre; Schaub Emmanuel; Muriaux Delphine; Cabanne Charlotte; Morellet Nelly; Bouaziz Serge; Darlix Jean-Luc; Mély Yves; de Rocquigny Hugues
Direct Vpr-Vpr interaction in cells monitored by two photon fluorescence correlation spectroscopy and fluorescence lifetime imaging.
Retrovirology 2008;5():87.
2008: Berkhout Ben; Gorelick Robert; Summers Michael F; Mély Yves; Darlix Jean-Luc
6th international symposium on retroviral nucleocapsid.
Retrovirology 2008;5():21.
2007: Ramalanjaona Nick; de Rocquigny Hugues; Millet Aurélie; Ficheux Damien; Darlix Jean-Luc; Mély Yves
Investigating the mechanism of the nucleocapsid protein chaperoning of the second strand transfer during HIV-1 DNA synthesis.
Journal of molecular biology 2007;374(4):1041-53.
2007: Egelé Caroline; Piémont Etienne; Didier Pascal; Ficheux Damien; Roques Bernard; Darlix Jean-Luc; de Rocquigny Hugues; Mély Yves
The single-finger nucleocapsid protein of moloney murine leukemia virus binds and destabilizes the TAR sequences of HIV-1 but does not promote efficiently their annealing.
Biochemistry 2007;46(50):14650-62.
2007: Ali Moez Ben; Chaminade Françoise; Kanevsky Igor; Ennifar Eric; Josset Laurence; Ficheux Damien; Darlix Jean-Luc; Fossé Philippe
Structural requirements for nucleocapsid protein-mediated dimerization of avian leukosis virus RNA.
Journal of molecular biology 2007;372(4):1082-96.
2007: Darlix Jean-Luc; Sitbon Marc
[Prostate cancer leads to the discovery of a new human infectious retrovirus]
Médecine sciences : M/S 2007;23(8-9):690-1.
2007: An Dong Sung; Donahue Robert E; Kamata Masakazu; Poon Betty; Metzger Mark; Mao Si-Hua; Bonifacino Aylin; Krouse Allen E; Darlix Jean-Luc; Baltimore David; Qin F Xiao-Feng; Chen Irvin S Y
Stable reduction of CCR5 by RNAi through hematopoietic stem cell transplant in non-human primates.
Proceedings of the National Academy of Sciences of the United States of America 2007;104(32):13110-5.
2007: Balvay Laurent; Lopez Lastra Marcelo; Sargueil Bruno; Darlix Jean-Luc; Ohlmann Théophile
Translational control of retroviruses.
Nature reviews. Microbiology 2007;5(2):128-40.
2007: Grigorov Boyan; Décimo Didier; Smagulova Fatima; Péchoux Christine; Mougel Marylène; Muriaux Delphine; Darlix Jean-Luc
Intracellular HIV-1 Gag localization is impaired by mutations in the nucleocapsid zinc fingers.
Retrovirology 2007;4():54.
2007: Darlix Jean-Luc; Garrido José Luis; Morellet Nelly; Mély Yves; de Rocquigny Hugues
Properties, functions, and drug targeting of the multifunctional nucleocapsid protein of the human immunodeficiency virus.
Advances in pharmacology (San Diego, Calif.) 2007;55():299-346.
2007: Rakotobe Dina; Tardy Jean-Claude; André Patrice; Hong Saw See; Darlix Jean-Luc; Boulanger Pierre
Human Polycomb group EED protein negatively affects HIV-1 assembly and release.
Retrovirology 2007;4():37.
2007: Gatignol Anne; Dubuisson Jean; Wainberg Mark A; Cohen Eric A; Darlix Jean-Luc
New pandemics: HIV and AIDS, HCV and chronic hepatitis, influenza virus and flu.
Retrovirology 2007;4():8.
2007: Goujon Caroline; Rivière Lise; Jarrosson-Wuilleme Loraine; Bernaud Jeanine; Rigal Dominique; Darlix Jean-Luc; Cimarelli Andrea
SIVSM/HIV-2 Vpx proteins promote retroviral escape from a proteasome-dependent restriction pathway present in human dendritic cells.
Retrovirology 2007;4():2.
2006: Raja Chinappan; Ferner Jan; Dietrich Ursula; Avilov Sergiy; Ficheux Damien; Darlix Jean-Luc; de Rocquigny Hugues; Schwalbe Harald; Mély Yves
A tryptophan-rich hexapeptide inhibits nucleic acid destabilization chaperoned by the HIV-1 nucleocapsid protein.
Biochemistry 2006;45(30):9254-65.
2006: Leblanc Pascal; Alais Sandrine; Porto-Carreiro Isabel; Lehmann Sylvain; Grassi Jacques; Raposo Graça; Darlix Jean Luc
Retrovirus infection strongly enhances scrapie infectivity release in cell culture.
The EMBO journal 2006;25(12):2674-85.
2006: Grigorov Boyan; Arcanger Fabienne; Roingeard Philippe; Darlix Jean-Luc; Muriaux Delphine
Assembly of infectious HIV-1 in human epithelial and T-lymphoblastic cell lines.
Journal of molecular biology 2006;359(4):848-62.
2006: Goujon C; Jarrosson-Wuillème L; Bernaud J; Rigal D; Darlix J-L; Cimarelli A
With a little help from a friend: increasing HIV transduction of monocyte-derived dendritic cells with virion-like particles of SIV(MAC).
Gene therapy 2006;13(12):991-4.
2006: Bampi Carole; Bibillo Arkadiusz; Wendeler Michaela; Divita Gilles; Gorelick Robert J; Le Grice Stuart F J; Darlix Jean-Luc
Nucleotide excision repair and template-independent addition by HIV-1 reverse transcriptase in the presence of nucleocapsid protein.
The Journal of biological chemistry 2006;281(17):11736-43.
2006: Godet Julien; de Rocquigny Hugues; Raja Chinnappan; Glasser Nicole; Ficheux Damien; Darlix Jean-Luc; Mély Yves
During the early phase of HIV-1 DNA synthesis, nucleocapsid protein directs hybridization of the TAR complementary sequences via the ends of their double-stranded stem.
Journal of molecular biology 2006;356(5):1180-92.
2006: Jarrosson-Wuilleme Loraine; Goujon Caroline; Bernaud Jeanine; Rigal Dominique; Darlix Jean-Luc; Cimarelli Andrea
Transduction of nondividing human macrophages with gammaretrovirus-derived vectors.
Journal of virology 2006;80(3):1152-9.
2006: Gabus Caroline; Ivanyi-Nagy Roland; Depollier Julien; Bucheton Alain; Pelisson Alain; Darlix Jean-Luc
Characterization of a nucleocapsid-like region and of two distinct primer tRNALys,2 binding sites in the endogenous retrovirus Gypsy.
Nucleic acids research 2006;34(20):5764-77.
2006: Ivanyi-Nagy Roland; Kanevsky Igor; Gabus Caroline; Lavergne Jean-Pierre; Ficheux Damien; Penin François; Fossé Philippe; Darlix Jean-Luc
Analysis of hepatitis C virus RNA dimerization and core-RNA interactions.
Nucleic acids research 2006;34(9):2618-33.
2005: Herbreteau Cécile H; Weill Laure; Décimo Didier; Prévôt Déborah; Darlix Jean-Luc; Sargueil Bruno; Ohlmann Théophile
HIV-2 genomic RNA contains a novel type of IRES located downstream of its initiation codon.
Nature structural & molecular biology 2005;12(11):1001-7.
2005: Bosch Berta; Blanco Julià; Pauls Eduardo; Clotet-Codina Imma; Armand-Ugón Mercedes; Grigorov Boyan; Muriaux Delphine; Clotet Bonaventura; Darlix Jean-Luc; Esté José A
Inhibition of coreceptor-independent cell-to-cell human immunodeficiency virus type 1 transmission by a CD4-immunoglobulin G2 fusion protein.
Antimicrobial agents and chemotherapy 2005;49(10):4296-304.
2005: Ivanyi-Nagy R; Davidovic L; Khandjian E W; Darlix J-L
Disordered RNA chaperone proteins: from functions to disease.
Cellular and molecular life sciences : CMLS 2005;62(13):1409-17.
2005: Beltz Hervé; Clauss Céline; Piémont Etienne; Ficheux Damien; Gorelick Robert J; Roques Bernard; Gabus Caroline; Darlix Jean-Luc; de Rocquigny Hugues; Mély Yves
Structural determinants of HIV-1 nucleocapsid protein for cTAR DNA binding and destabilization, and correlation with inhibition of self-primed DNA synthesis.
Journal of molecular biology 2005;348(5):1113-26.
2005: Kanevsky Igor; Chaminade Françoise; Ficheux Damien; Moumen Abdeladim; Gorelick Robert; Negroni Matteo; Darlix Jean-Luc; Fossé Philippe
Specific interactions between HIV-1 nucleocapsid protein and the TAR element.
Journal of molecular biology 2005;348(5):1059-77.
2005: Perron Hervé; Lazarini Françoise; Ruprecht Klemens; Péchoux-Longin Christine; Seilhean Danielle; Sazdovitch Véronique; Créange Alain; Battail-Poirot Nicole; Sibaï Geneviève; Santoro Lyse; Jolivet Michel; Darlix Jean-Luc; Rieckmann Peter; Arzberger Thomas; Hauw Jean-Jacques; Lassmann Hans
Human endogenous retrovirus (HERV)-W ENV and GAG proteins: physiological expression in human brain and pathophysiological modulation in multiple sclerosis lesions.
Journal of neurovirology 2005;11(1):23-33.
2005: Derrington Edmund A; López-Lastra Marcelo; Darlix Jean-Luc
Dicistronic MLV-retroviral vectors transduce neural precursors in vivo and co-express two genes in their differentiated neuronal progeny.
Retrovirology 2005;2():60.
2005: Jacquenet Sandrine; Decimo Didier; Muriaux Delphine; Darlix Jean-Luc
Dual effect of the SR proteins ASF/SF2, SC35 and 9G8 on HIV-1 RNA splicing and virion production.
Retrovirology 2005;2():33.
2004: Egelé Caroline; Schaub Emmanuel; Ramalanjaona Nick; Piémont Etienne; Ficheux Damien; Roques Bernard; Darlix Jean-Luc; Mély Yves
HIV-1 nucleocapsid protein binds to the viral DNA initiation sequences and chaperones their kissing interactions.
Journal of molecular biology 2004;342(2):453-66.
2004: Bampi Carole; Jacquenet Sandrine; Lener Daniela; Décimo Didier; Darlix Jean-Luc
The chaperoning and assistance roles of the HIV-1 nucleocapsid protein in proviral DNA synthesis and maintenance.
The international journal of biochemistry & cell biology 2004;36(9):1668-86.
2004: Sandrin Virginie; Muriaux Delphine; Darlix Jean-Luc; Cosset François-Loïc
Intracellular trafficking of Gag and Env proteins and their interactions modulate pseudotyping of retroviruses.
Journal of virology 2004;78(13):7153-64.
2004: Beltz Hervé; Piémont Etienne; Schaub Emmanuel; Ficheux Damien; Roques Bernard; Darlix Jean-Luc; Mély Yves
Role of the structure of the top half of HIV-1 cTAR DNA on the nucleic acid destabilizing activity of the nucleocapsid protein NCp7.
Journal of molecular biology 2004;338(4):711-23.
2004: Leblanc Pascal; Baas Dominique; Darlix Jean-Luc
Analysis of the interactions between HIV-1 and the cellular prion protein in a human cell line.
Journal of molecular biology 2004;337(4):1035-51.
2004: Ronfort Corinne; De Breyne Sylvain; Sandrin Virginie; Darlix Jean-Luc; Ohlmann Théophile
Characterization of two distinct RNA domains that regulate translation of the Drosophila gypsy retroelement.
RNA (New York, N.Y.) 2004;10(3):504-15.
2004: Bampi Carole; Jacquenet Sandrine; Lener Daniela; Décimo Didier; Darlix Jean-Luc
The chaperoning and assistance roles of the HIV-1 nucleocapsid protein in proviral DNA synthesis and maintenance.
Current HIV research 2004;2(1):79-92.
2004: Muriaux D; Darlix J L; Cimarelli A
Targeting the assembly of the human immunodeficiency virus type I.
Current pharmaceutical design 2004;10(30):3725-39.
2004: Cristofari Gaël; Ivanyi-Nagy Roland; Gabus Caroline; Boulant Steeve; Lavergne Jean-Pierre; Penin François; Darlix Jean-Luc
The hepatitis C virus Core protein is a potent nucleic acid chaperone that directs dimerization of the viral (+) strand RNA in vitro.
Nucleic acids research 2004;32(8):2623-31.
2004: Gabus Caroline; Mazroui Rachid; Tremblay Sandra; Khandjian Edouard W; Darlix Jean-Luc
The fragile X mental retardation protein has nucleic acid chaperone properties.
Nucleic acids research 2004;32(7):2129-37.
2003: Krishnamoorthy G; Roques Bernard; Darlix Jean-Luc; Mély Yves
DNA condensation by the nucleocapsid protein of HIV-1: a mechanism ensuring DNA protection.
Nucleic acids research 2003;31(18):5425-32.
2003: Goujon Caroline; Jarrosson-Wuilleme Loraine; Bernaud Jeanine; Rigal Dominique; Darlix Jean-Luc; Cimarelli Andrea
Heterologous human immunodeficiency virus type 1 lentiviral vectors packaging a simian immunodeficiency virus-derived genome display a specific postentry transduction defect in dendritic cells.
Journal of virology 2003;77(17):9295-304.
2003: Poljak Leonora; Batson Susan M; Ficheux Damien; Roques Bernard P; Darlix Jean-Luc; Käs Emmanuel
Analysis of NCp7-dependent activation of HIV-1 cDNA integration and its conservation among retroviral nucleocapsid proteins.
Journal of molecular biology 2003;329(3):411-21.
2003: Prévôt Déborah; Darlix Jean-Luc; Ohlmann Théophile
Conducting the initiation of protein synthesis: the role of eIF4G.
Biology of the cell / under the auspices of the European Cell Biology Organization 2003;95(3-4):141-56.
2003: Beltz Hervé; Azoulay Joel; Bernacchi Serena; Clamme Jean-Pierre; Ficheux Damien; Roques Bernard; Darlix Jean-Luc; Mély Yves
Impact of the terminal bulges of HIV-1 cTAR DNA on its stability and the destabilizing activity of the nucleocapsid protein NCp7.
Journal of molecular biology 2003;328(1):95-108.
2003: Prévôt Déborah; Décimo Didier; Herbreteau Cécile H; Roux Florence; Garin Jérôme; Darlix Jean-Luc; Ohlmann Théophile
Characterization of a novel RNA-binding region of eIF4GI critical for ribosomal scanning.
The EMBO journal 2003;22(8):1909-21.
2003: Brasey Ann; Lopez-Lastra Marcelo; Ohlmann Theophile; Beerens Nancy; Berkhout Ben; Darlix Jean-Luc; Sonenberg Nahum
The leader of human immunodeficiency virus type 1 genomic RNA harbors an internal ribosome entry segment that is active during the G2/M phase of the cell cycle.
Journal of virology 2003;77(7):3939-49.
2003: Jullien Jérôme; Guili Vincent; Derrington Edmund A; Darlix Jean-Luc; Reichardt Louis F; Rudkin Brian B
Trafficking of TrkA-green fluorescent protein chimerae during nerve growth factor-induced differentiation.
The Journal of biological chemistry 2003;278(10):8706-16.
2003: Azoulay Joel; Clamme Jean Pierre; Darlix Jean Luc; Roques Bernard P; Mély Yves
Destabilization of the HIV-1 complementary sequence of TAR by the nucleocapsid protein through activation of conformational fluctuations.
Journal of molecular biology 2003;326(3):691-700.
2002: Cristofari Gaël; Bampi Carole; Wilhelm Marcelle; Wilhelm François-Xavier; Darlix Jean-Luc
A 5'-3' long-range interaction in Ty1 RNA controls its reverse transcription and retrotransposition.
The EMBO journal 2002;21(16):4368-79.
2002: Cimarelli A; Darlix J L
Assembling the human immunodeficiency virus type 1.
Cellular and molecular life sciences : CMLS 2002;59(7):1166-84.
2002: Moscardini Mila; Pistello Mauro; Bendinelli M; Ficheux Damien; Miller Jennifer T; Gabus Caroline; Le Grice Stuart F J; Surewicz Witold K; Darlix Jean-Luc
Functional interactions of nucleocapsid protein of feline immunodeficiency virus and cellular prion protein with the viral RNA.
Journal of molecular biology 2002;318(1):149-59.
2002: Ohlmann Théophile; Prévôt Déborah; Décimo Didier; Roux Florence; Garin Jérôme; Morley Simon J; Darlix Jean-Luc
In vitro cleavage of eIF4GI but not eIF4GII by HIV-1 protease and its effects on translation in the rabbit reticulocyte lysate system.
Journal of molecular biology 2002;318(1):9-20.
2002: Bernacchi Serena; Stoylov Stoyl; Piémont Etienne; Ficheux Damien; Roques Bernard P; Darlix Jean Luc; Mély Yves
HIV-1 nucleocapsid protein activates transient melting of least stable parts of the secondary structure of TAR and its complementary sequence.
Journal of molecular biology 2002;317(3):385-99.
2002: Mangeot Philippe-Emmanuel; Duperrier Karine; Nègre Didier; Boson Bertrand; Rigal Dominique; Cosset François-Loïc; Darlix Jean-Luc
High levels of transduction of human dendritic cells with optimized SIV vectors.
Molecular therapy : the journal of the American Society of Gene Therapy 2002;5(3):283-90.
2002: Nymark-McMahon M Henrietta; Beliakova-Bethell Nadejda S; Darlix Jean-Luc; Le Grice Stuart F J; Sandmeyer Suzanne B
Ty3 integrase is required for initiation of reverse transcription.
Journal of virology 2002;76(6):2804-16.
2002: Derrington Edmund; Gabus Caroline; Leblanc Pascal; Chnaidermann Jonas; Grave Linda; Dormont Dominique; Swietnicki Wieslaw; Morillas Manuel; Marck Daniel; Nandi Pradip; Darlix Jean-Luc
PrPC has nucleic acid chaperoning properties similar to the nucleocapsid protein of HIV-1.
Comptes rendus biologies 2002;325(1):17-23.
2002: Cristofari Gaël; Darlix Jean-Luc
The ubiquitous nature of RNA chaperone proteins.
Progress in nucleic acid research and molecular biology 2002;72():223-68.
2002: Nègre D; Duisit G; Mangeot P E; Moullier P; Darlix J L; Cosset F L
Lentiviral vectors derived from simian immunodeficiency virus.
Current topics in microbiology and immunology 2002;261():53-74.
2001: Franceschini I A; Feigenbaum-Lacombe V; Casanova P; Lopez-Lastra M; Darlix J L; Dalcq M D
Efficient gene transfer in mouse neural precursors with a bicistronic retroviral vector.
Journal of neuroscience research 2001;65(3):208-19.
2001: Gabus C; Derrington E; Leblanc P; Chnaiderman J; Dormont D; Swietnicki W; Morillas M; Surewicz W K; Marc D; Nandi P; Darlix J L
The prion protein has RNA binding and chaperoning properties characteristic of nucleocapsid protein NCP7 of HIV-1.
The Journal of biological chemistry 2001;276(22):19301-9.
2001: Gabus C; Auxilien S; Péchoux C; Dormont D; Swietnicki W; Morillas M; Surewicz W; Nandi P; Darlix J L
The prion protein has DNA strand transfer properties similar to retroviral nucleocapsid protein.
Journal of molecular biology 2001;307(4):1011-21.
2001: Laughrea M; Shen N; Jetté L; Darlix J L; Kleiman L; Wainberg M A
Role of distal zinc finger of nucleocapsid protein in genomic RNA dimerization of human immunodeficiency virus type 1; no role for the palindrome crowning the R-U5 hairpin.
Virology 2001;281(1):109-16.
2000: Nègre D; Mangeot P E; Duisit G; Blanchard S; Vidalain P O; Leissner P; Winter A J; Rabourdin-Combe C; Mehtali M; Moullier P; Darlix J L; Cosset F L
Characterization of novel safe lentiviral vectors derived from simian immunodeficiency virus (SIVmac251) that efficiently transduce mature human dendritic cells.
Gene therapy 2000;7(19):1613-23.
2000: Mangeot P E; Nègre D; Dubois B; Winter A J; Leissner P; Mehtali M; Kaiserlian D; Cosset F L; Darlix J L
Development of minimal lentivirus vectors derived from simian immunodeficiency virus (SIVmac251) and their use for gene transfer into human dendritic cells.
Journal of virology 2000;74(18):8307-15.
2000: Polge E; Darlix J L; Paoletti J; Fossé P
Characterization of loose and tight dimer forms of avian leukosis virus RNA.
Journal of molecular biology 2000;300(1):41-56.
2000: Cristofari G; Ficheux D; Darlix J L
The GAG-like protein of the yeast Ty1 retrotransposon contains a nucleic acid chaperone domain analogous to retroviral nucleocapsid proteins.
The Journal of biological chemistry 2000;275(25):19210-7.
2000: Ohlmann T; Lopez-Lastra M; Darlix J L
An internal ribosome entry segment promotes translation of the simian immunodeficiency virus genomic RNA.
The Journal of biological chemistry 2000;275(16):11899-906.
2000: Darlix J L; Cristofari G; Rau M; Péchoux C; Berthoux L; Roques B
Nucleocapsid protein of human immunodeficiency virus as a model protein with chaperoning functions and as a target for antiviral drugs.
Advances in pharmacology (San Diego, Calif.) 2000;48():345-72.
1999: Cristofari G; Gabus C; Ficheux D; Bona M; Le Grice S F; Darlix J L
Characterization of active reverse transcriptase and nucleoprotein complexes of the yeast retrotransposon Ty3 in vitro.
The Journal of biological chemistry 1999;274(51):36643-8.
1999: Berthoux L; Péchoux C; Darlix J L
Multiple effects of an anti-human immunodeficiency virus nucleocapsid inhibitor on virus morphology and replication.
Journal of virology 1999;73(12):10000-9.
1999: López-Lastra M; Ulrici S; Gabus C; Darlix J L
Identification of an internal ribosome entry segment in the 5' region of the mouse VL30 retrotransposon and its use in the development of retroviral vectors.
Journal of virology 1999;73(10):8393-402.
1999: Derrington E A; López-Lastra M; Chapel-Fernandez S; Cosset F L; Belin M F; Rudkin B B; Darlix J L
Retroviral vectors for the expression of two genes in human multipotent neural precursors and their differentiated neuronal and glial progeny.
Human gene therapy 1999;10(7):1129-38.
1999: Cen S; Huang Y; Khorchid A; Darlix J L; Wainberg M A; Kleiman L
The role of Pr55(gag) in the annealing of tRNA3Lys to human immunodeficiency virus type 1 genomic RNA.
Journal of virology 1999;73(5):4485-8.
1998: Lener D; Tanchou V; Roques B P; Le Grice S F; Darlix J L
Involvement of HIV-I nucleocapsid protein in the recruitment of reverse transcriptase into nucleoprotein complexes formed in vitro.
The Journal of biological chemistry 1998;273(50):33781-6.
1998: Yu Q; Ottmann M; Pechoux C; Le Grice S; Darlix J L
Mutations in the primer grip of human immunodeficiency virus type 1 reverse transcriptase impair proviral DNA synthesis and virion maturation.
Journal of virology 1998;72(9):7676-80.
1998: Gabus C; Ficheux D; Rau M; Keith G; Sandmeyer S; Darlix J L
The yeast Ty3 retrotransposon contains a 5'-3' bipartite primer-binding site and encodes nucleocapsid protein NCp9 functionally homologous to HIV-1 NCp7.
The EMBO journal 1998;17(16):4873-80.
1998: Rascle J B; Ficheux D; Darlix J L
Possible roles of nucleocapsid protein of MoMuLV in the specificity of proviral DNA synthesis and in the genetic variability of the virus.
Journal of molecular biology 1998;280(2):215-25.
1998: Tanchou V; Decimo D; Péchoux C; Lener D; Rogemond V; Berthoux L; Ottmann M; Darlix J L
Role of the N-terminal zinc finger of human immunodeficiency virus type 1 nucleocapsid protein in virus structure and replication.
Journal of virology 1998;72(5):4442-7.
1998: Huang Y; Khorchid A; Gabor J; Wang J; Li X; Darlix J L; Wainberg M A; Kleiman L
The role of nucleocapsid and U5 stem/A-rich loop sequences in tRNA(3Lys) genomic placement and initiation of reverse transcription in human immunodeficiency virus type 1.
Journal of virology 1998;72(5):3907-15.
1998: Allain B; Rascle J B; de Rocquigny H; Roques B; Darlix J L
CIS elements and trans-acting factors required for minus strand DNA transfer during reverse transcription of the genomic RNA of murine leukemia virus.
Journal of molecular biology 1998;277(2):225-35.
1997: de Rocquigny H; Petitjean P; Tanchou V; Decimo D; Drouot L; Delaunay T; Darlix J L; Roques B P
The zinc fingers of HIV nucleocapsid protein NCp7 direct interactions with the viral regulatory protein Vpr.
The Journal of biological chemistry 1997;272(49):30753-9.
1997: López-Lastra M; Gabus C; Darlix J L
Characterization of an internal ribosomal entry segment within the 5' leader of avian reticuloendotheliosis virus type A RNA and development of novel MLV-REV-based retroviral vectors.
Human gene therapy 1997;8(16):1855-65.
1997: Berthoux L; Péchoux C; Ottmann M; Morel G; Darlix J L
Mutations in the N-terminal domain of human immunodeficiency virus type 1 nucleocapsid protein affect virion core structure and proviral DNA synthesis.
Journal of virology 1997;71(9):6973-81.
1997: Carteau S; Batson S C; Poljak L; Mouscadet J F; de Rocquigny H; Darlix J L; Roques B P; Käs E; Auclair C
Human immunodeficiency virus type 1 nucleocapsid protein specifically stimulates Mg2+-dependent DNA integration in vitro.
Journal of virology 1997;71(8):6225-9.
1997: Huang Y; Khorchid A; Wang J; Parniak M A; Darlix J L; Wainberg M A; Kleiman L
Effect of mutations in the nucleocapsid protein (NCp7) upon Pr160(gag-pol) and tRNA(Lys) incorporation into human immunodeficiency virus type 1.
Journal of virology 1997;71(6):4378-84.
1997: Lapadat-Tapolsky M; Gabus C; Rau M; Darlix J L
Possible roles of HIV-1 nucleocapsid protein in the specificity of proviral DNA synthesis and in its variability.
Journal of molecular biology 1997;268(2):250-60.
1996: Fossé P; Motté N; Roumier A; Gabus C; Muriaux D; Darlix J L; Paoletti J
A short autocomplementary sequence plays an essential role in avian sarcoma-leukosis virus RNA dimerization.
Biochemistry 1996;35(51):16601-9.
1996: Paillart J C; Berthoux L; Ottmann M; Darlix J L; Marquet R; Ehresmann B; Ehresmann C
A dual role of the putative RNA dimerization initiation site of human immunodeficiency virus type 1 in genomic RNA packaging and proviral DNA synthesis.
Journal of virology 1996;70(12):8348-54.
1996: Li X; Quan Y; Arts E J; Li Z; Preston B D; de Rocquigny H; Roques B P; Darlix J L; Kleiman L; Parniak M A; Wainberg M A
Human immunodeficiency virus Type 1 nucleocapsid protein (NCp7) directs specific initiation of minus-strand DNA synthesis primed by human tRNA(Lys3) in vitro: studies of viral RNA molecules mutated in regions that flank the primer binding site.
Journal of virology 1996;70(8):4996-5004.
1996: Ghosh M; Jacques P S; Rodgers D W; Ottman M; Darlix J L; Le Grice S F
Alterations to the primer grip of p66 HIV-1 reverse transcriptase and their consequences for template-primer utilization.
Biochemistry 1996;35(26):8553-62.
1996: Torrent C; Berlioz C; Darlix J L
Stable MLV-VL30 dicistronic retroviral vectors with a VL30 or MoMLV sequence promoting both packaging of genomic RNA and expression of the 3' cistron.
Human gene therapy 1996;7(5):603-12.
1996: Housset V; Darlix J L
Mutations at the capsid-nucleocapsid cleavage site of gag polyprotein of Moloney murine leukemia virus abolish virus infectivity.
Comptes rendus de l'Académie des sciences. Série III, Sciences de la vie 1996;319(2):81-9.
1995: Darlix J L; Lapadat-Tapolsky M; de Rocquigny H; Roques B P
First glimpses at structure-function relationships of the nucleocapsid protein of retroviruses.
Journal of molecular biology 1995;254(4):523-37.
1995: Berlioz C; Torrent C; Darlix J L
An internal ribosomal entry signal in the rat VL30 region of the Harvey murine sarcoma virus leader and its use in dicistronic retroviral vectors.
Journal of virology 1995;69(10):6400-7.
1995: Tanchou V; Delaunay T; Bodéus M; Roques B; Darlix J L; Benarous R
Conformational changes between human immunodeficiency virus type 1 nucleocapsid protein NCp7 and its precursor NCp15 as detected by anti-NCp7 monoclonal antibodies.
The Journal of general virology 1995;76 ( Pt 10)():2457-66.
1995: Tanchou V; Gabus C; Rogemond V; Darlix J L
Formation of stable and functional HIV-1 nucleoprotein complexes in vitro.
Journal of molecular biology 1995;252(5):563-71.
1995: Lapadat-Tapolsky M; Pernelle C; Borie C; Darlix J L
Analysis of the nucleic acid annealing activities of nucleocapsid protein from HIV-1.
Nucleic acids research 1995;23(13):2434-41.
1995: Berlioz C; Darlix J L
An internal ribosomal entry mechanism promotes translation of murine leukemia virus gag polyprotein precursors.
Journal of virology 1995;69(4):2214-22.
1995: Ottmann M; Gabus C; Darlix J L
The central globular domain of the nucleocapsid protein of human immunodeficiency virus type 1 is critical for virion structure and infectivity.
Journal of virology 1995;69(3):1778-84.
1994: Déméné H; Dong C Z; Ottmann M; Rouyez M C; Jullian N; Morellet N; Mely Y; Darlix J L; Fournié-Zaluski M C; Saragosti S
1H NMR structure and biological studies of the His23-->Cys mutant nucleocapsid protein of HIV-1 indicate that the conformation of the first zinc finger is critical for virus infectivity.
Biochemistry 1994;33(39):11707-16.
1994: Jacques P S; Wöhrl B M; Ottmann M; Darlix J L; Le Grice S F
Mutating the "primer grip" of p66 HIV-1 reverse transcriptase implicates tryptophan-229 in template-primer utilization.
The Journal of biological chemistry 1994;269(42):26472-8.
1994: Tanchou V; Delaunay T; De Rocquigny H; Bodeus M; Darlix J L; Roques B; Benarous R
Monoclonal antibody-mediated inhibition of RNA binding and annealing activities of HIV type 1 nucleocapsid protein.
AIDS research and human retroviruses 1994;10(8):983-93.
1994: Torrent C; Bordet T; Darlix J L
Analytical study of rat retrotransposon VL30 RNA dimerization in vitro and packaging in murine leukemia virus.
Journal of molecular biology 1994;240(5):434-44.
1994: Corbin A; Prats A C; Darlix J L; Sitbon M
A nonstructural gag-encoded glycoprotein precursor is necessary for efficient spreading and pathogenesis of murine leukemia viruses.
Journal of virology 1994;68(6):3857-67.
1994: Torrent C; Gabus C; Darlix J L
A small and efficient dimerization/packaging signal of rat VL30 RNA and its use in murine leukemia virus-VL30-derived vectors for gene transfer.
Journal of virology 1994;68(2):661-7.
1994: Allain B; Lapadat-Tapolsky M; Berlioz C; Darlix J L
Transactivation of the minus-strand DNA transfer by nucleocapsid protein during reverse transcription of the retroviral genome.
The EMBO journal 1994;13(4):973-81.
1994: Morellet N; de Rocquigny H; Mély Y; Jullian N; Déméné H; Ottmann M; Gérard D; Darlix J L; Fournie-Zaluski M C; Roques B P
Conformational behaviour of the active and inactive forms of the nucleocapsid NCp7 of HIV-1 studied by 1H NMR.
Journal of molecular biology 1994;235(1):287-301.
1993: Mougel M; Tounekti N; Darlix J L; Paoletti J; Ehresmann B; Ehresmann C
Conformational analysis of the 5' leader and the gag initiation site of Mo-MuLV RNA and allosteric transitions induced by dimerization.
Nucleic acids research 1993;21(20):4677-84.
1993: Bieth E; Darlix J L
Characterization of a molecular clone of a highly infectious avian leukosis virus.
Comptes rendus de l'Académie des sciences. Série III, Sciences de la vie 1993;316(8):754-62.
1993: Darlix J L; Vincent A; Gabus C; de Rocquigny H; Roques B
Trans-activation of the 5' to 3' viral DNA strand transfer by nucleocapsid protein during reverse transcription of HIV1 RNA.
Comptes rendus de l'Académie des sciences. Série III, Sciences de la vie 1993;316(8):763-71.
1993: Housset V; De Rocquigny H; Roques B P; Darlix J L
Basic amino acids flanking the zinc finger of Moloney murine leukemia virus nucleocapsid protein NCp10 are critical for virus infectivity.
Journal of virology 1993;67(5):2537-45.
1993: Barat C; Schatz O; Le Grice S; Darlix J L
Analysis of the interactions of HIV1 replication primer tRNA(Lys,3) with nucleocapsid protein and reverse transcriptase.
Journal of molecular biology 1993;231(2):185-90.
1993: De Rocquigny H; Ficheux D; Gabus C; Allain B; Fournie-Zaluski M C; Darlix J L; Roques B P
Two short basic sequences surrounding the zinc finger of nucleocapsid protein NCp10 of Moloney murine leukemia virus are critical for RNA annealing activity.
Nucleic acids research 1993;21(4):823-9.
1993: Lapadat-Tapolsky M; De Rocquigny H; Van Gent D; Roques B; Plasterk R; Darlix J L
Interactions between HIV-1 nucleocapsid protein and viral DNA may have important functions in the viral life cycle.
Nucleic acids research 1993;21(4):831-9.
1993: Baudin F; Marquet R; Isel C; Darlix J L; Ehresmann B; Ehresmann C
Functional sites in the 5' region of human immunodeficiency virus type 1 RNA form defined structural domains.
Journal of molecular biology 1993;229(2):382-97.
1992: Darlix J L; Gabus C; Allain B
Analytical study of avian reticuloendotheliosis virus dimeric RNA generated in vivo and in vitro.
Journal of virology 1992;66(12):7245-52.
1992: Morellet N; Jullian N; De Rocquigny H; Maigret B; Darlix J L; Roques B P
Determination of the structure of the nucleocapsid protein NCp7 from the human immunodeficiency virus type 1 by 1H NMR.
The EMBO journal 1992;11(8):3059-65.
1992: De Rocquigny H; Gabus C; Vincent A; Fournié-Zaluski M C; Roques B; Darlix J L
Viral RNA annealing activities of human immunodeficiency virus type 1 nucleocapsid protein require only peptide domains outside the zinc fingers.
Proceedings of the National Academy of Sciences of the United States of America 1992;89(14):6472-6.
1992: Lederer H; Schatz O; May R; Crespi H; Darlix J L; Le Grice S F; Heumann H
Domain structure of the human immunodeficiency virus reverse transcriptase.
The EMBO journal 1992;11(3):1131-9.
1992: Tounekti N; Mougel M; Roy C; Marquet R; Darlix J L; Paoletti J; Ehresmann B; Ehresmann C
Effect of dimerization on the conformation of the encapsidation Psi domain of Moloney murine leukemia virus RNA.
Journal of molecular biology 1992;223(1):205-20.
1992: Bieth E; Darlix J L
Complete nucleotide sequence of a highly infectious avian leukosis virus.
Nucleic acids research 1992;20(2):367.
1992: Torrent C; Wang P; Darlix J L
A murine leukemia virus derived retroviral vector with a rat VL30 packaging psi sequence.
Bone marrow transplantation 1992;9 Suppl 1():143-7.
1991: Le Grice S F; Panin M; Kalayjian R C; Richter N J; Keith G; Darlix J L; Payne S L
Purification and characterization of recombinant equine infectious anemia virus reverse transcriptase.
Journal of virology 1991;65(12):7004-7.
1991: de Rocquigny H; Ficheux D; Gabus C; Fournié-Zaluski M C; Darlix J L; Roques B P
First large scale chemical synthesis of the 72 amino acid HIV-1 nucleocapsid protein NCp7 in an active form.
Biochemical and biophysical research communications 1991;180(2):1010-8.
1991: Prats A C; Housset V; de Billy G; Cornille F; Prats H; Roques B; Darlix J L
Viral RNA annealing activities of the nucleocapsid protein of Moloney murine leukemia virus are zinc independent.
Nucleic acids research 1991;19(13):3533-41.
1991: Mely Y; Cornille F; Fournié-Zaluski M C; Darlix J L; Roques B P; Gérard D
Investigation of zinc-binding affinities of Moloney murine leukemia virus nucleocapsid protein and its related zinc finger and modified peptides.
Biopolymers 1991;31(7):899-906.
1991: Marquet R; Baudin F; Gabus C; Darlix J L; Mougel M; Ehresmann C; Ehresmann B
Dimerization of human immunodeficiency virus (type 1) RNA: stimulation by cations and possible mechanism.
Nucleic acids research 1991;19(9):2349-57.
1991: Barat C; Le Grice S F; Darlix J L
Interaction of HIV-1 reverse transcriptase with a synthetic form of its replication primer, tRNA(Lys,3).
Nucleic acids research 1991;19(4):751-7.
1990: Roy C; Tounekti N; Mougel M; Darlix J L; Paoletti C; Ehresmann C; Ehresmann B; Paoletti J
An analytical study of the dimerization of in vitro generated RNA of Moloney murine leukemia virus MoMuLV.
Nucleic acids research 1990;18(24):7287-92.
1990: Darlix J L; Gabus C; Nugeyre M T; Clavel F; Barré-Sinoussi F
Cis elements and trans-acting factors involved in the RNA dimerization of the human immunodeficiency virus HIV-1.
Journal of molecular biology 1990;216(3):689-99.
1990: Cornille F; Mely Y; Ficheux D; Savignol I; Gerard D; Darlix J L; Fournie-Zaluski M C; Roques B P
Solid phase synthesis of the retroviral nucleocapsid protein NCp10 of Moloney murine leukaemia virus and related "zinc-fingers" in free SH forms. Influence of zinc chelation on structural and biochemical properties.
International journal of peptide and protein research 1990;36(6):551-8.
1990: Prats A C; Roy C; Wang P A; Erard M; Housset V; Gabus C; Paoletti C; Darlix J L
cis elements and trans-acting factors involved in dimer formation of murine leukemia virus RNA.
Journal of virology 1990;64(2):774-83.
1990: Bieth E; Gabus C; Darlix J L
A study of the dimer formation of Rous sarcoma virus RNA and of its effect on viral protein synthesis in vitro.
Nucleic acids research 1990;18(1):119-27.
1989: Barat C; Lullien V; Schatz O; Keith G; Nugeyre M T; Grüninger-Leitch F; Barré-Sinoussi F; LeGrice S F; Darlix J L
HIV-1 reverse transcriptase specifically interacts with the anticodon domain of its cognate primer tRNA.
The EMBO journal 1989;8(11):3279-85.
1989: Prats A C; De Billy G; Wang P; Darlix J L
CUG initiation codon used for the synthesis of a cell surface antigen coded by the murine leukemia virus.
Journal of molecular biology 1989;205(2):363-72.
1988: Prats A C; Sarih L; Gabus C; Litvak S; Keith G; Darlix J L
Small finger protein of avian and murine retroviruses has nucleic acid annealing activity and positions the replication primer tRNA onto genomic RNA.
The EMBO journal 1988;7(6):1777-83.

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