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Bryant Darnay

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TOP 3
Betty Lamothe; Michael D Schneider; Min Xie; YunJu Lai; Bryant G Darnay
TAK1 is essential for osteoclast differentiation and is an important modulator of cell death by apoptosis and necroptosis.
Wei-Lei Yang; Asad Moten; Dazhi Xu; Zhen Cai; Wei Chen; Bryant G Darnay; Zizhen Feng; Wei Gu; Yun Seong Jeong; Guoxiang Jin; Chien-Feng Li; Hui-Kuan Lin
Cycles of ubiquitination and deubiquitination critically regulate growth factor-mediated activation of Akt signaling.
Yixin Yao; Dos Sarbassov; Tattym E Shaiken; Milind Suraokar; James L Abbruzzese; Takayuki Asano; Benny H-J Chang; Chien-Hung Chen; Bryant G Darnay; Brett G Hollier; Yiling Lu; Sendurai Mani; Gordon B Mills; Shrikanth A G Reddy
BSTA promotes mTORC2-mediated phosphorylation of Akt1 to suppress expression of FoxC2 and stimulate adipocyte differentiation.

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All Publications

2013: Betty Lamothe; Michael D Schneider; Min Xie; YunJu Lai; Bryant G Darnay
TAK1 is essential for osteoclast differentiation and is an important modulator of cell death by apoptosis and necroptosis.
Molecular and cellular biology 2013;33(3):582-95.
2013: Wei-Lei Yang; Asad Moten; Dazhi Xu; Zhen Cai; Wei Chen; Bryant G Darnay; Zizhen Feng; Wei Gu; Yun Seong Jeong; Guoxiang Jin; Chien-Feng Li; Hui-Kuan Lin
Cycles of ubiquitination and deubiquitination critically regulate growth factor-mediated activation of Akt signaling.
Science signaling 2013;6(257):ra3.
2013: Yixin Yao; Dos Sarbassov; Tattym E Shaiken; Milind Suraokar; James L Abbruzzese; Takayuki Asano; Benny H-J Chang; Chien-Hung Chen; Bryant G Darnay; Brett G Hollier; Yiling Lu; Sendurai Mani; Gordon B Mills; Shrikanth A G Reddy
BSTA promotes mTORC2-mediated phosphorylation of Akt1 to suppress expression of FoxC2 and stimulate adipocyte differentiation.
Science signaling 2013;6(257):ra2.
2013: Bo Zhong; Bryant G Darnay; Hongxiu Li; Xin Lin; Xindong Liu; Xikui Liu; Shao-Cong Sun; Xiaohu Wang; Chen Dong
Ubiquitin-Specific Protease 25 Regulates TLR4-Dependent Innate Immune Responses Through Deubiquitination of the Adaptor Protein TRAF3.
Science signaling 2013;6(275):ra35.
2012: Sara Gorjestani; Bryant G Darnay; Xin Lin
Tumor necrosis factor receptor-associated factor 6 (TRAF6) and TGFβ-activated kinase 1 (TAK1) play essential roles in the C-type lectin receptor signaling in response to Candida albicans infection.
The Journal of biological chemistry 2012;287(53):44143-50.
2012: Pardyut K Paul; Sanjay Srivastava; Vivek Mishra; Shephali Bhatnagar; Yongwon Choi; Bryant G Darnay; Ashok Kumar
The E3 ubiquitin ligase TRAF6 intercedes in starvation-induced skeletal muscle atrophy through multiple mechanisms.
Molecular and cellular biology 2012;32(7):1248-59.
2012: Betty Lamothe; Hui-Kuan Lin; Cynthia R Lockworth; Natalia Martin Orozco; Michael D Schneider; Diep Tran; Jing Wang; Min Xie; Sity Dawud; Chen Dong; Zeev Estrov; Michael Ho; Peter Hu; Lana Hur; Jared Jakacky; Yunju Lai; Carlos E Bueso-Ramos; Alejandro D Campos; Bryant G Darnay
Deletion of TAK1 in the myeloid lineage results in the spontaneous development of myelomonocytic leukemia in mice.
PloS one 2012;7(12):e51228.
2011: Ching-Yuan Wu; Juan Wu; Wei-Lei Yang; Xian Zhang; Jing Wang; Alejandro D Campos; Chia-Hsin Chan; Bryant G Darnay; Yun Seong Jeong; Hong-Yo Kang; Betty Lamothe; Szu-Wei Lee; Hui-Kuan Lin
Critical role of monoubiquitination of histone H2AX protein in histone H2AX phosphorylation and DNA damage response.
The Journal of biological chemistry 2011;286(35):30806-15.
2011: Montserrat Rodríguez; Noelia Artime; Lucía Cabal-Hierro; María Teresa Carcedo; Bryant G Darnay; Juan-Manuel Iglesias; Pedro S Lazo
NF-kappaB signal triggering and termination by tumor necrosis factor receptor 2.
The Journal of biological chemistry 2011;286(26):22814-24.
2010: Pardyut K Paul; Sanjay K Gupta; Shephali Bhatnagar; Siva K Panguluri; Bryant G Darnay; Yongwon Choi; Ashok Kumar
Targeted ablation of TRAF6 inhibits skeletal muscle wasting in mice.
The Journal of cell biology 2010;191(7):1395-411.
2010: Xin Zhou; Zhaoping Zhang; Jian Q Feng; Vladmir M Dusevich; Krishna Sinha; Hua Zhang; Bryant G Darnay; Benoit de Crombrugghe
Multiple functions of Osterix are required for bone growth and homeostasis in postnatal mice.
Proceedings of the National Academy of Sciences of the United States of America 2010;107(29):12919-24.
2009: Qian Yin; Betty Lamothe; Bryant G Darnay; Hao Wu
Structural basis for the lack of E2 interaction in the RING domain of TRAF2.
Biochemistry 2009;48(44):10558-67.
2009: John C Araujo; Ann Poblenz; Paul Corn; Nila U Parikh; Michael W Starbuck; Jerry T Thompson; Francis Lee; Christopher J Logothetis; Bryant G Darnay
Dasatinib inhibits both osteoclast activation and prostate cancer PC-3-cell-induced osteoclast formation.
Cancer biology & therapy 2009;8(22):2153-9.
2009: Wei-Lei Yang; Jing Wang; Chia-Hsin Chan; Szu-Wei Lee; Alejandro D Campos; Betty Lamothe; Lana Hur; Brian Grabiner; Xin Lin; Bryant G Darnay; Hui-Kuan Lin
The E3 ligase TRAF6 regulates Akt ubiquitination and activation.
Science (New York, N.Y.) 2009;325(5944):1134-8.
2009: Michael Düwel; Verena Welteke; Andrea Oeckinghaus; Mathijs Baens; Bernhard Kloo; Uta Ferch; Bryant G Darnay; Jürgen Ruland; Peter Marynen; Daniel Krappmann
A20 negatively regulates T cell receptor signaling to NF-kappaB by cleaving Malt1 ubiquitin chains.
Journal of immunology (Baltimore, Md. : 1950) 2009;182(12):7718-28.
2009: Qian Yin; Su-Chang Lin; Betty Lamothe; Miao Lu; Yu-Chih Lo; Gregory Hura; Lixin Zheng; Rebecca L Rich; Alejandro D Campos; David G Myszka; Michael J Lenardo; Bryant G Darnay; Hao Wu
E2 interaction and dimerization in the crystal structure of TRAF6.
Nature structural & molecular biology 2009;16(6):658-66.
2008: Mei Yee Koh; Bryant G Darnay; Garth Powis
Hypoxia-associated factor, a novel E3-ubiquitin ligase, binds and ubiquitinates hypoxia-inducible factor 1alpha, leading to its oxygen-independent degradation.
Molecular and cellular biology 2008;28(23):7081-95.
2008: Shunbin Ning; Alex D Campos; Bryant G Darnay; Gretchen L Bentz; Joseph S Pagano
TRAF6 and the three C-terminal lysine sites on IRF7 are required for its ubiquitination-mediated activation by the tumor necrosis factor receptor family member latent membrane protein 1.
Molecular and cellular biology 2008;28(20):6536-46.
2008: Betty Lamothe; Alejandro D Campos; William K Webster; Ambily Gopinathan; Lana Hur; Bryant G Darnay
The RING domain and first zinc finger of TRAF6 coordinate signaling by interleukin-1, lipopolysaccharide, and RANKL.
The Journal of biological chemistry 2008;283(36):24871-80.
2008: Ji Wu; Feng Meng; Ling-Yuan Kong; Zhenghong Peng; Yunming Ying; William G Bornmann; Bryant G Darnay; Betty Lamothe; Hanshi Sun; Moshe Talpaz; Nicholas J Donato
Association between imatinib-resistant BCR-ABL mutation-negative leukemia and persistent activation of LYN kinase.
Journal of the National Cancer Institute 2008;100(13):926-39.
2008: Rajesh R Nair; Hector Avila; Xujun Ma; Zhengxin Wang; Michelle Lennartz; Bryant G Darnay; Douglas D Boyd; Chunhong Yan
A novel high-throughput screening system identifies a small molecule repressive for matrix metalloproteinase-9 expression.
Molecular pharmacology 2008;73(3):919-29.
2008: Jackie A Fretz; Nirupama K Shevde; Sujay Singh; Bryant G Darnay; J Wesley Pike
Receptor activator of nuclear factor-kappaB ligand-induced nuclear factor of activated T cells (C1) autoregulates its own expression in osteoclasts and mediates the up-regulation of tartrate-resistant acid phosphatase.
Molecular endocrinology (Baltimore, Md.) 2008;22(3):737-50.
2008: Lan V Pham; Hai-Jun Zhou; Yen-Chiu Lin-Lee; Archito Tamayo; Linda C Yoshimura; Lingchen Fu; Bryant G Darnay; Richard J Ford
Nuclear tumor necrosis factor receptor-associated factor 6 in lymphoid cells negatively regulates c-Myb-mediated transactivation through small ubiquitin-related modifier-1 modification.
The Journal of biological chemistry 2008;283(8):5081-9.
2008: Su-Chang Lin; Jee Y Chung; Betty Lamothe; Kanagalaghatta Rajashankar; Miao Lu; Yu-Chih Lo; Amy Y Lam; Bryant G Darnay; Hao Wu
Molecular basis for the unique deubiquitinating activity of the NF-kappaB inhibitor A20.
Journal of molecular biology 2008;376(2):526-40.
2008: Hiroaki Kimura; Kin Ming Kwan; Zhaoping Zhang; Jian Min Deng; Bryant G Darnay; Richard R Behringer; Takashi Nakamura; Benoit de Crombrugghe; Haruhiko Akiyama
Cthrc1 is a positive regulator of osteoblastic bone formation.
PloS one 2008;3(9):e3174.
2007: Betty Lamothe; William K Webster; Ambily Gopinathan; Arnaud Besse; Alejandro D Campos; Bryant G Darnay
TRAF6 ubiquitin ligase is essential for RANKL signaling and osteoclast differentiation.
Biochemical and biophysical research communications 2007;359(4):1044-9.
2007: Arnaud Besse; Alejandro D Campos; William K Webster; Bryant G Darnay
TRAF-interacting protein (TRIP) is a RING-dependent ubiquitin ligase.
Biochemical and biophysical research communications 2007;359(3):660-4.
2007: Ann T Poblenz; Joerg J Jacoby; Sujay Singh; Bryant G Darnay
Inhibition of RANKL-mediated osteoclast differentiation by selective TRAF6 decoy peptides.
Biochemical and biophysical research communications 2007;359(3):510-5.
2007: Brian Grabiner; Marzenna Blonska; Pei-Chun Lin; Yun You; Donghai Wang; Jiyuan Sun; Bryant G Darnay; Chen Dong; Xin Lin
CARMA3 deficiency abrogates G protein-coupled receptor-induced NF-{kappa}B activation.
Genes & development 2007;21(8):984-96.
2007: Prashant B Shambharkar; Marzenna Blonska; Bhanu P Pappu; Hongxiu Li; Yun You; Hiroaki Sakurai; Bryant G Darnay; Hiromitsu Hara; Josef M Penninger; Xin Lin
Phosphorylation and ubiquitination of the IkappaB kinase complex by two distinct signaling pathways.
The EMBO journal 2007;26(7):1794-805.
2007: D G Jackson-Bernitsas; Haruyo Ichikawa; Yasunari Takada; Jeffrey N Myers; X L Lin; Bryant G Darnay; Madan M Chaturvedi; Bharat B Aggarwal
Evidence that TNF-TNFR1-TRADD-TRAF2-RIP-TAK1-IKK pathway mediates constitutive NF-kappaB activation and proliferation in human head and neck squamous cell carcinoma.
Oncogene 2007;26(10):1385-97.
2007: Arnaud Besse; Betty Lamothe; Alejandro D Campos; William K Webster; Upendra Maddineni; Su-Chang Lin; Hao Wu; Bryant G Darnay
TAK1-dependent signaling requires functional interaction with TAB2/TAB3.
The Journal of biological chemistry 2007;282(6):3918-28.
2007: Betty Lamothe; Arnaud Besse; Alejandro D Campos; William K Webster; Hao Wu; Bryant G Darnay
Site-specific Lys-63-linked tumor necrosis factor receptor-associated factor 6 auto-ubiquitination is a critical determinant of I kappa B kinase activation.
The Journal of biological chemistry 2007;282(6):4102-12.
2007: Bryant G Darnay; Arnaud Besse; Ann T Poblenz; Betty Lamothe; Jörg J Jacoby
TRAFs in RANK signaling.
Advances in experimental medicine and biology 2007;597():152-9.
2006: Khalid A Mohamedali; Ann T Poblenz; Charles R Sikes; Nora M Navone; Philip E Thorpe; Bryant G Darnay; Michael G Rosenblum
Inhibition of prostate tumor growth and bone remodeling by the vascular targeting agent VEGF121/rGel.
Cancer research 2006;66(22):10919-28.
2003: Tara C Polek; Moshe Talpaz; Bryant G Darnay; Taly Spivak-Kroizman
TWEAK mediates signal transduction and differentiation of RAW264.7 cells in the absence of Fn14/TweakR. Evidence for a second TWEAK receptor.
The Journal of biological chemistry 2003;278(34):32317-23.
2002: Hong Ye; Joseph R Arron; Betty Lamothe; Maurizio Cirilli; Takashi Kobayashi; Nirupama K Shevde; Deena Segal; Oki K Dzivenu; Masha Vologodskaia; Mijung Yim; Khoi Du; Sujay Singh; J Wesley Pike; Bryant G Darnay; Yongwon Choi; Hao Wu
Distinct molecular mechanism for initiating TRAF6 signalling.
Nature 2002;418(6896):443-7.
1999: Bryant G Darnay; Bharat B Aggarwal
Signal transduction by tumour necrosis factor and tumour necrosis factor related ligands and their receptors.
Annals of the rheumatic diseases 1999;58 Suppl 1():I2-I13.
1999: Bryant G Darnay; Jian Ni; Paul Moore; Bharat B Aggarwal
Activation of NF-kappaB by RANK requires tumor necrosis factor receptor-associated factor (TRAF) 6 and NF-kappaB-inducing kinase. Identification of a novel TRAF6 interaction motif.
The Journal of biological chemistry 1999;274(12):7724-31.
1998: Bryant G Darnay; Valsala Haridas; Jian Ni; Paul Moore; Bharat B Aggarwal
Characterization of the intracellular domain of receptor activator of NF-kappaB (RANK). Interaction with tumor necrosis factor receptor-associated factors and activation of NF-kappab and c-Jun N-terminal kinase.
The Journal of biological chemistry 1998;273(32):20551-5.
1998: Valsala Haridas; Bryant G Darnay; K Natarajan; R Heller; Bharat B Aggarwal
Overexpression of the p80 TNF receptor leads to TNF-dependent apoptosis, nuclear factor-kappa B activation, and c-Jun kinase activation.
Journal of immunology (Baltimore, Md. : 1950) 1998;160(7):3152-62.
1997: Madan M Chaturvedi; Addanki Kumar; Bryant G Darnay; gagan chainy; S Agarwal; Bharat B Aggarwal
Sanguinarine (pseudochelerythrine) is a potent inhibitor of NF-kappaB activation, IkappaBalpha phosphorylation, and degradation.
The Journal of biological chemistry 1997;272(48):30129-34.
1997: Bryant G Darnay; Bharat B Aggarwal
Inhibition of protein tyrosine phosphatases causes phosphorylation of tyrosine-331 in the p60 TNF receptor and inactivates the receptor-associated kinase.
FEBS letters 1997;410(2-3):361-7.
1997: Bryant G Darnay; Bharat B Aggarwal
Early events in TNF signaling: a story of associations and dissociations.
Journal of leukocyte biology 1997;61(5):559-66.
1997: Bryant G Darnay; S Singh; Bharat B Aggarwal
The p80 TNF receptor-associated kinase (p80TRAK) associates with residues 354-397 of the p80 cytoplasmic domain: similarity to casein kinase.
FEBS letters 1997;406(1-2):101-5.
1996: Saurabh Singh; Bryant G Darnay; Bharat B Aggarwal
Site-specific tyrosine phosphorylation of IkappaBalpha negatively regulates its inducible phosphorylation and degradation.
The Journal of biological chemistry 1996;271(49):31049-54.
1996: M J Frederick; L V Rodriguez; D A Johnston; Bryant G Darnay; Elizabeth A Grimm
Characterization of the M(r) 65,000 lymphokine-activated killer proteins phosphorylated after tumor target binding: evidence that pp65a and pp65b are phosphorylated forms of L-plastin.
Cancer research 1996;56(1):138-44.
1995: Bryant G Darnay; Saurabh Singh; Madan M Chaturvedi; Bharat B Aggarwal
The p60 tumor necrosis factor (TNF) receptor-associated kinase (TRAK) binds residues 344-397 within the cytoplasmic domain involved in TNF signaling.
The Journal of biological chemistry 1995;270(25):14867-70.
1994: Shrikanth A G Reddy; Madan M Chaturvedi; Bryant G Darnay; H Chan; M Higuchi; Bharat B Aggarwal
Reconstitution of nuclear factor kappa B activation induced by tumor necrosis factor requires membrane-associated components. Comparison with pathway activated by ceramide.
The Journal of biological chemistry 1994;269(41):25369-72.
1994: K Totpal; Ruth Lapushin; T Kohno; Bryant G Darnay; Bharat B Aggarwal
TNF and its receptor antibody agonist differ in mediation of cellular responses.
Journal of immunology (Baltimore, Md. : 1950) 1994;153(5):2248-57.
1994: Bryant G Darnay; Shrikanth A G Reddy; Bharat B Aggarwal
Identification of a protein kinase associated with the cytoplasmic domain of the p60 tumor necrosis factor receptor.
The Journal of biological chemistry 1994;269(32):20299-304.
1994: Bryant G Darnay; Shrikanth A G Reddy; Bharat B Aggarwal
Physical and functional association of a serine-threonine protein kinase to the cytoplasmic domain of the p80 form of the human tumor necrosis factor receptor in human histiocytic lymphoma U-937 cells.
The Journal of biological chemistry 1994;269(31):19687-90.