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James Darnell

This is a preview profile on BiomedExperts - the first literature-based scientific social network. It brings the right researchers together and allows them to collaborate online. Collexis and Dell provide the BiomedExperts network of +1.5 Million pre-calculated profiles free of charge to researchers worldwide.

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Chemicals & Drugs

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Mice

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Amino Acid Sequence

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Co-Publications
Name
14
Wen, Z
12
Levy, David
11
Horvath, Curt
9
Bromberg, Jacqueline
9
Decker, Thomas
8
Xanthopoulos, Kleanthis
7
Shuai, Ke
7
Stark, George
7
Lai, Eseng
7
Schindler, Christian
7
Kerr, Ian
6
Costa, Robert
6
Vinkemeier, Uwe
5
Yang, Edward
5
Grayson, Dennis

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Publications

TOP 3
Ahmed Simi T; Darnell James E
Serpin B3/B4, activated by STAT3, promote survival of squamous carcinoma cells.
Betz Aurel; Ryoo Hyung Don; Steller Hermann; Darnell James E
STAT92E is a positive regulator of Drosophila inhibitor of apoptosis 1 (DIAP/1) and protects against radiation-induced apoptosis.
Mertens Claudia; Darnell James E
SnapShot: JAK-STAT signaling.

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All Publications

2009: Ahmed Simi T; Darnell James E
Serpin B3/B4, activated by STAT3, promote survival of squamous carcinoma cells.
Biochemical and biophysical research communications 2009;378(4):821-5.
2008: Betz Aurel; Ryoo Hyung Don; Steller Hermann; Darnell James E
STAT92E is a positive regulator of Drosophila inhibitor of apoptosis 1 (DIAP/1) and protects against radiation-induced apoptosis.
Proceedings of the National Academy of Sciences of the United States of America 2008;105(37):13805-10.
2007: Mertens Claudia; Darnell James E
SnapShot: JAK-STAT signaling.
Cell 2007;131(3):612.
2007: Ginsberg Michael; Czeko Elmar; Müller Patrick; Ren Zhiyong; Chen Xiaomin; Darnell James E
Amino acid residues required for physical and cooperative transcriptional interaction of STAT3 and AP-1 proteins c-Jun and c-Fos.
Molecular and cellular biology 2007;27(18):6300-8.
2007: Darnell J E
Interferon research: impact on understanding transcriptional control.
Current topics in microbiology and immunology 2007;316():155-63.
2006: Mertens Claudia; Zhong Minghao; Krishnaraj Ravi; Zou Wenxin; Chen Xiaomin; Darnell James E
Dephosphorylation of phosphotyrosine on STAT1 dimers requires extensive spatial reorientation of the monomers facilitated by the N-terminal domain.
Genes & development 2006;20(24):3372-81.
2006: Betz Aurel; Darnell James E
A Hopscotch-chromatin connection.
Nature genetics 2006;38(9):977-9.
2006: Leslie Kenneth; Lang Cynthia; Devgan Geeta; Azare Janeen; Berishaj Marjan; Gerald William; Kim Young Bae; Paz Keren; Darnell James E; Albanese Christopher; Sakamaki Toshiyuki; Pestell Richard; Bromberg Jacqueline
Cyclin D1 is transcriptionally regulated by and required for transformation by activated signal transducer and activator of transcription 3.
Cancer research 2006;66(5):2544-52.
2005: Shen Yuhong; La Perle Krista M D; Levy David E; Darnell James E
Reduced STAT3 activity in mice mimics clinical disease syndromes.
Biochemical and biophysical research communications 2005;330(1):305-9.
2005: Mao Xiang; Ren Zhiyong; Parker Gregory N; Sondermann Holger; Pastorello Michael A; Wang Wei; McMurray John S; Demeler Borries; Darnell James E; Chen Xiaomin
Structural bases of unphosphorylated STAT1 association and receptor binding.
Molecular cell 2005;17(6):761-71.
2005: Zhong Minghao; Henriksen Melissa A; Takeuchi Kenji; Schaefer Olaf; Liu Bin; ten Hoeve Johanna; Ren Zhiyong; Mao Xiang; Chen Xiaomin; Shuai Ke; Darnell James E
Implications of an antiparallel dimeric structure of nonphosphorylated STAT1 for the activation-inactivation cycle.
Proceedings of the National Academy of Sciences of the United States of America 2005;102(11):3966-71.
2004: Paz Keren; Socci Nicholas D; van Nimwegen Erik; Viale Agnes; Darnell James E
Transformation fingerprint: induced STAT3-C, v-Src and Ha-Ras cause small initial changes but similar established profiles in mRNA.
Oncogene 2004;23(52):8455-63.
2004: Shen Yuhong; Schlessinger Karni; Zhu Xuejun; Meffre Eric; Quimby Fred; Levy David E; Darnell J E
Essential role of STAT3 in postnatal survival and growth revealed by mice lacking STAT3 serine 727 phosphorylation.
Molecular and cellular biology 2004;24(1):407-19.
2003: Lerner Lorena; Henriksen Melissa A; Zhang Xiaokui; Darnell James E
STAT3-dependent enhanceosome assembly and disassembly: synergy with GR for full transcriptional increase of the alpha 2-macroglobulin gene.
Genes & development 2003;17(20):2564-77.
2003: Zakharova Natalia; Lymar Elena S; Yang Edward; Malik Sohail; Zhang J Jillian; Roeder Robert G; Darnell James E
Distinct transcriptional activation functions of STAT1alpha and STAT1beta on DNA and chromatin templates.
The Journal of biological chemistry 2003;278(44):43067-73.
2003: Yang Edward; van Nimwegen Erik; Zavolan Mihaela; Rajewsky Nikolaus; Schroeder Mark; Magnasco Marcelo; Darnell James E
Decay rates of human mRNAs: correlation with functional characteristics and sequence attributes.
Genome research 2003;13(8):1863-72.
2003: Yang Edward; Lerner Lorena; Besser Daniel; Darnell James E
Independent and cooperative activation of chromosomal c-fos promoter by STAT3.
The Journal of biological chemistry 2003;278(18):15794-9.
2003: Chen Xiaomin; Bhandari Rashna; Vinkemeier Uwe; Van Den Akker Focco; Darnell James E; Kuriyan John
A reinterpretation of the dimerization interface of the N-terminal domains of STATs.
Protein science : a publication of the Protein Society 2003;12(2):361-5.
2002: Darnell James E
Transcription factors as targets for cancer therapy.
Nature reviews. Cancer 2002;2(10):740-9.
2002: Darnell James E
Special Achienvement in Medical Science Award. The surprises of mammalian molecular cell biology.
Nature medicine 2002;8(10):1068-71.
2002: Henriksen Melissa A; Betz Aurel; Fuccillo Marc V; Darnell James E
Negative regulation of STAT92E by an N-terminally truncated STAT protein derived from an alternative promoter site.
Genes & development 2002;16(18):2379-89.
2002: Yang Edward; Henriksen Melissa A; Schaefer Olaf; Zakharova Natalia; Darnell James E
Dissociation time from DNA determines transcriptional function in a STAT1 linker mutant.
The Journal of biological chemistry 2002;277(16):13455-62.
2002: Brivanlou Ali H; Darnell James E
Signal transduction and the control of gene expression.
Science (New York, N.Y.) 2002;295(5556):813-8.
2001: Zhang X; Darnell J E
Functional importance of Stat3 tetramerization in activation of the alpha 2-macroglobulin gene.
The Journal of biological chemistry 2001;276(36):33576-81.
2001: Betz A; Lampen N; Martinek S; Young M W; Darnell J E
A Drosophila PIAS homologue negatively regulates stat92E.
Proceedings of the National Academy of Sciences of the United States of America 2001;98(17):9563-8.
2001: Shen Y; Darnell J E
Antiviral response in cells containing Stat1 with heterologous transactivation domains.
Journal of virology 2001;75(6):2627-33.
2001: Shen Y; Devgan G; Darnell J E; Bromberg J F
Constitutively activated Stat3 protects fibroblasts from serum withdrawal and UV-induced apoptosis and antagonizes the proapoptotic effects of activated Stat1.
Proceedings of the National Academy of Sciences of the United States of America 2001;98(4):1543-8.
2000: Bromberg J; Darnell J E
The role of STATs in transcriptional control and their impact on cellular function.
Oncogene 2000;19(21):2468-73.
1999: Zhang X; Wrzeszczynska M H; Horvath C M; Darnell J E
Interacting regions in Stat3 and c-Jun that participate in cooperative transcriptional activation.
Molecular and cellular biology 1999;19(10):7138-46.
1999: Haspel R L; Darnell J E
A nuclear protein tyrosine phosphatase is required for the inactivation of Stat1.
Proceedings of the National Academy of Sciences of the United States of America 1999;96(18):10188-93.
1999: Bromberg J F; Wrzeszczynska M H; Devgan G; Zhao Y; Pestell R G; Albanese C; Darnell J E
Stat3 as an oncogene.
Cell 1999;98(3):295-303.
1999: Yang E; Wen Z; Haspel R L; Zhang J J; Darnell J E
The linker domain of Stat1 is required for gamma interferon-driven transcription.
Molecular and cellular biology 1999;19(7):5106-12.
1999: Darnell J E
E.B. Wilson Lecture, 1998. Eukaryotic RNAs: once more from the beginning.
Molecular biology of the cell 1999;10(6):1685-92.
1999: John S; Vinkemeier U; Soldaini E; Darnell J E; Leonard W J
The significance of tetramerization in promoter recruitment by Stat5.
Molecular and cellular biology 1999;19(3):1910-8.
1999: Besser D; Bromberg J F; Darnell J E; Hanafusa H
A single amino acid substitution in the v-Eyk intracellular domain results in activation of Stat3 and enhances cellular transformation.
Molecular and cellular biology 1999;19(2):1401-9.
1999: Bromberg J F; Darnell J E
Potential roles of Stat1 and Stat3 in cellular transformation.
Cold Spring Harbor symposia on quantitative biology 1999;64():425-8.
1998: Zhang J J; Zhao Y; Chait B T; Lathem W W; Ritzi M; Knippers R; Darnell J E
Ser727-dependent recruitment of MCM5 by Stat1alpha in IFN-gamma-induced transcriptional activation.
The EMBO journal 1998;17(23):6963-71.
1998: Bromberg J F; Fan Z; Brown C; Mendelsohn J; Darnell J E
Epidermal growth factor-induced growth inhibition requires Stat1 activation.
Cell growth & differentiation : the molecular biology journal of the American Association for Cancer Research 1998;9(7):505-12.
1998: Chen X; Vinkemeier U; Zhao Y; Jeruzalmi D; Darnell J E; Kuriyan J
Crystal structure of a tyrosine phosphorylated STAT-1 dimer bound to DNA.
Cell 1998;93(5):827-39.
1998: Bromberg J F; Horvath C M; Besser D; Lathem W W; Darnell J E
Stat3 activation is required for cellular transformation by v-src.
Molecular and cellular biology 1998;18(5):2553-8.
1998: Vinkemeier U; Moarefi I; Darnell J E; Kuriyan J
Structure of the amino-terminal protein interaction domain of STAT-4.
Science (New York, N.Y.) 1998;279(5353):1048-52.
1997: Zhu X; Wen Z; Xu L Z; Darnell J E
Stat1 serine phosphorylation occurs independently of tyrosine phosphorylation and requires an activated Jak2 kinase.
Molecular and cellular biology 1997;17(11):6618-23.
1997: Darnell J E
Phosphotyrosine signaling and the single cell:metazoan boundary.
Proceedings of the National Academy of Sciences of the United States of America 1997;94(22):11767-9.
1997: Darnell J E
STATs and gene regulation.
Science (New York, N.Y.) 1997;277(5332):1630-5.
1997: Wen Z; Darnell J E
Mapping of Stat3 serine phosphorylation to a single residue (727) and evidence that serine phosphorylation has no influence on DNA binding of Stat1 and Stat3.
Nucleic acids research 1997;25(11):2062-7.
1997: Horvath C M; Darnell J E
The state of the STATs: recent developments in the study of signal transduction to the nucleus.
Current opinion in cell biology 1997;9(2):233-9.
1997: Duncan S A; Zhong Z; Wen Z; Darnell J E
STAT signaling is active during early mammalian development.
Developmental dynamics : an official publication of the American Association of Anatomists 1997;208(2):190-8.
1996: Zhang J J; Vinkemeier U; Gu W; Chakravarti D; Horvath C M; Darnell J E
Two contact regions between Stat1 and CBP/p300 in interferon gamma signaling.
Proceedings of the National Academy of Sciences of the United States of America 1996;93(26):15092-6.
1996: Horvath C M; Stark G R; Kerr I M; Darnell J E
Interactions between STAT and non-STAT proteins in the interferon-stimulated gene factor 3 transcription complex.
Molecular and cellular biology 1996;16(12):6957-64.
1996: Haspel R L; Salditt-Georgieff M; Darnell J E
The rapid inactivation of nuclear tyrosine phosphorylated Stat1 depends upon a protein tyrosine phosphatase.
The EMBO journal 1996;15(22):6262-8.
1996: Vinkemeier U; Cohen S L; Moarefi I; Chait B T; Kuriyan J; Darnell J E
DNA binding of in vitro activated Stat1 alpha, Stat1 beta and truncated Stat1: interaction between NH2-terminal domains stabilizes binding of two dimers to tandem DNA sites.
The EMBO journal 1996;15(20):5616-26.
1996: Zong C; Yan R; August A; Darnell J E; Hanafusa H
Unique signal transduction of Eyk: constitutive stimulation of the JAK-STAT pathway by an oncogenic receptor-type tyrosine kinase.
The EMBO journal 1996;15(17):4515-25.
1996: Vaisse C; Halaas J L; Horvath C M; Darnell J E; Stoffel M; Friedman J M
Leptin activation of Stat3 in the hypothalamus of wild-type and ob/ob mice but not db/db mice.
Nature genetics 1996;14(1):95-7.
1996: Bromberg J F; Horvath C M; Wen Z; Schreiber R D; Darnell J E
Transcriptionally active Stat1 is required for the antiproliferative effects of both interferon alpha and interferon gamma.
Proceedings of the National Academy of Sciences of the United States of America 1996;93(15):7673-8.
1996: Darnell J E
Reflections on STAT3, STAT5, and STAT6 as fat STATs.
Proceedings of the National Academy of Sciences of the United States of America 1996;93(13):6221-4.
1996: Yan R; Luo H; Darnell J E; Dearolf C R
A JAK-STAT pathway regulates wing vein formation in Drosophila.
Proceedings of the National Academy of Sciences of the United States of America 1996;93(12):5842-7.
1996: Yan R; Small S; Desplan C; Dearolf C R; Darnell J E
Identification of a Stat gene that functions in Drosophila development.
Cell 1996;84(3):421-30.
1996: Qureshi S A; Leung S; Kerr I M; Stark G R; Darnell J E
Function of Stat2 protein in transcriptional activation by alpha interferon.
Molecular and cellular biology 1996;16(1):288-93.
1996: Horvath C M; Darnell J E
The antiviral state induced by alpha interferon and gamma interferon requires transcriptionally active Stat1 protein.
Journal of virology 1996;70(1):647-50.
1995: Copeland N G; Gilbert D J; Schindler C; Zhong Z; Wen Z; Darnell J E; Mui A L; Miyajima A; Quelle F W; Ihle J N
Distribution of the mammalian Stat gene family in mouse chromosomes.
Genomics 1995;29(1):225-8.
1995: Boulton T G; Zhong Z; Wen Z; Darnell J E; Stahl N; Yancopoulos G D
STAT3 activation by cytokines utilizing gp130 and related transducers involves a secondary modification requiring an H7-sensitive kinase.
Proceedings of the National Academy of Sciences of the United States of America 1995;92(15):6915-9.
1995: Wen Z; Zhong Z; Darnell J E
Maximal activation of transcription by Stat1 and Stat3 requires both tyrosine and serine phosphorylation.
Cell 1995;82(2):241-50.
1995: Horvath C M; Wen Z; Darnell J E
A STAT protein domain that determines DNA sequence recognition suggests a novel DNA-binding domain.
Genes & development 1995;9(8):984-94.
1995: Qureshi S A; Salditt-Georgieff M; Darnell J E
Tyrosine-phosphorylated Stat1 and Stat2 plus a 48-kDa protein all contact DNA in forming interferon-stimulated-gene factor 3.
Proceedings of the National Academy of Sciences of the United States of America 1995;92(9):3829-33.
1995: Stahl N; Farruggella T J; Boulton T G; Zhong Z; Darnell J E; Yancopoulos G D
Choice of STATs and other substrates specified by modular tyrosine-based motifs in cytokine receptors.
Science (New York, N.Y.) 1995;267(5202):1349-53.
1995: Heim M H; Kerr I M; Stark G R; Darnell J E
Contribution of STAT SH2 groups to specific interferon signaling by the Jak-STAT pathway.
Science (New York, N.Y.) 1995;267(5202):1347-9.
1995: Yan R; Qureshi S; Zhong Z; Wen Z; Darnell J E
The genomic structure of the STAT genes: multiple exons in coincident sites in Stat1 and Stat2.
Nucleic acids research 1995;23(3):459-63.
1995: Gronowski A M; Zhong Z; Wen Z; Thomas M J; Darnell J E; Rotwein P
In vivo growth hormone treatment rapidly stimulates the tyrosine phosphorylation and activation of Stat3.
Molecular endocrinology (Baltimore, Md.) 1995;9(2):171-7.
1995: Schindler C; Darnell J E
Transcriptional responses to polypeptide ligands: the JAK-STAT pathway.
Annual review of biochemistry 1995;64():621-51.
1994: Zhong W; Mirkovitch J; Darnell J E
Tissue-specific regulation of mouse hepatocyte nuclear factor 4 expression.
Molecular and cellular biology 1994;14(11):7276-84.
1994: Chen W S; Manova K; Weinstein D C; Duncan S A; Plump A S; Prezioso V R; Bachvarova R F; Darnell J E
Disruption of the HNF-4 gene, expressed in visceral endoderm, leads to cell death in embryonic ectoderm and impaired gastrulation of mouse embryos.
Genes & development 1994;8(20):2466-77.
1994: Ruff-Jamison S; Zhong Z; Wen Z; Chen K; Darnell J E; Cohen S
Epidermal growth factor and lipopolysaccharide activate Stat3 transcription factor in mouse liver.
The Journal of biological chemistry 1994;269(35):21933-5.
1994: Weinstein D C; Ruiz i Altaba A; Chen W S; Hoodless P; Prezioso V R; Jessell T M; Darnell J E
The winged-helix transcription factor HNF-3 beta is required for notochord development in the mouse embryo.
Cell 1994;78(4):575-88.
1994: Duncan S A; Manova K; Chen W S; Hoodless P; Weinstein D C; Bachvarova R F; Darnell J E
Expression of transcription factor HNF-4 in the extraembryonic endoderm, gut, and nephrogenic tissue of the developing mouse embryo: HNF-4 is a marker for primary endoderm in the implanting blastocyst.
Proceedings of the National Academy of Sciences of the United States of America 1994;91(16):7598-602.
1994: Darnell J E; Kerr I M; Stark G R
Jak-STAT pathways and transcriptional activation in response to IFNs and other extracellular signaling proteins.
Science (New York, N.Y.) 1994;264(5164):1415-21.
1994: Improta T; Schindler C; Horvath C M; Kerr I M; Stark G R; Darnell J E
Transcription factor ISGF-3 formation requires phosphorylated Stat91 protein, but Stat113 protein is phosphorylated independently of Stat91 protein.
Proceedings of the National Academy of Sciences of the United States of America 1994;91(11):4776-80.
1994: Zhong Z; Wen Z; Darnell J E
Stat3 and Stat4: members of the family of signal transducers and activators of transcription.
Proceedings of the National Academy of Sciences of the United States of America 1994;91(11):4806-10.
1994: Zhong Z; Wen Z; Darnell J E
Stat3: a STAT family member activated by tyrosine phosphorylation in response to epidermal growth factor and interleukin-6.
Science (New York, N.Y.) 1994;264(5155):95-8.
1994: Shuai K; Horvath C M; Huang L H; Qureshi S A; Cowburn D; Darnell J E
Interferon activation of the transcription factor Stat91 involves dimerization through SH2-phosphotyrosyl peptide interactions.
Cell 1994;76(5):821-8.
1993: Ruiz i Altaba A; Prezioso V R; Darnell J E; Jessell T M
Sequential expression of HNF-3 beta and HNF-3 alpha by embryonic organizing centers: the dorsal lip/node, notochord and floor plate.
Mechanisms of development 1993;44(2-3):91-108.
1993: Shuai K; Ziemiecki A; Wilks A F; Harpur A G; Sadowski H B; Gilman M Z; Darnell J E
Polypeptide signalling to the nucleus through tyrosine phosphorylation of Jak and Stat proteins.
Nature 1993;366(6455):580-3.
1993: Lai E; Clark K L; Burley S K; Darnell J E
Hepatocyte nuclear factor 3/fork head or "winged helix" proteins: a family of transcription factors of diverse biologic function.
Proceedings of the National Academy of Sciences of the United States of America 1993;90(22):10421-3.
1993: Müller M; Laxton C; Briscoe J; Schindler C; Improta T; Darnell J E; Stark G R; Kerr I M
Complementation of a mutant cell line: central role of the 91 kDa polypeptide of ISGF3 in the interferon-alpha and -gamma signal transduction pathways.
The EMBO journal 1993;12(11):4221-8.
1993: Sadowski H B; Shuai K; Darnell J E; Gilman M Z
A common nuclear signal transduction pathway activated by growth factor and cytokine receptors.
Science (New York, N.Y.) 1993;261(5129):1739-44.
1993: Shuai K; Stark G R; Kerr I M; Darnell J E
A single phosphotyrosine residue of Stat91 required for gene activation by interferon-gamma.
Science (New York, N.Y.) 1993;261(5129):1744-6.
1993: Zhong W; Sladek F M; Darnell J E
The expression pattern of a Drosophila homolog to the mouse transcription factor HNF-4 suggests a determinative role in gut formation.
The EMBO journal 1993;12(2):537-44.
1992: Shuai K; Schindler C; Prezioso V R; Darnell J E
Activation of transcription by IFN-gamma: tyrosine phosphorylation of a 91-kD DNA binding protein.
Science (New York, N.Y.) 1992;258(5089):1808-12.
1992: Mirkovitch J; Darnell J E
Mapping of RNA polymerase on mammalian genes in cells and nuclei.
Molecular biology of the cell 1992;3(10):1085-94.
1992: Xanthopoulos K G; Cannon P D; Robinson G S; Mirkovitch J; Darnell J E
Transiently and stably introduced CCAAT/enhancer-binding-protein genes are constitutively expressed in cultured cells.
European journal of biochemistry / FEBS 1992;208(2):501-9.
1992: Veals S A; Schindler C; Leonard D; Fu X Y; Aebersold R; Darnell J E; Levy D E
Subunit of an alpha-interferon-responsive transcription factor is related to interferon regulatory factor and Myb families of DNA-binding proteins.
Molecular and cellular biology 1992;12(8):3315-24.
1992: Fu X Y; Schindler C; Improta T; Aebersold R; Darnell J E
The proteins of ISGF-3, the interferon alpha-induced transcriptional activator, define a gene family involved in signal transduction.
Proceedings of the National Academy of Sciences of the United States of America 1992;89(16):7840-3.
1992: Schindler C; Fu X Y; Improta T; Aebersold R; Darnell J E
Proteins of transcription factor ISGF-3: one gene encodes the 91-and 84-kDa ISGF-3 proteins that are activated by interferon alpha.
Proceedings of the National Academy of Sciences of the United States of America 1992;89(16):7836-9.
1992: Schindler C; Shuai K; Prezioso V R; Darnell J E
Interferon-dependent tyrosine phosphorylation of a latent cytoplasmic transcription factor.
Science (New York, N.Y.) 1992;257(5071):809-13.
1992: Avraham K B; Prezioso V R; Chen W S; Lai E; Sladek F M; Zhong W; Darnell J E; Jenkins N A; Copeland N G
Murine chromosomal location of four hepatocyte-enriched transcription factors: HNF-3 alpha, HNF-3 beta, HNF-3 gamma, and HNF-4.
Genomics 1992;13(2):264-8.
1992: Mirkovitch J; Decker T; Darnell J E
Interferon induction of gene transcription analyzed by in vivo footprinting.
Molecular and cellular biology 1992;12(1):1-9.
1991: Kuo F C; Darnell J E
Evidence that interaction of hepatocytes with the collecting (hepatic) veins triggers position-specific transcription of the glutamine synthetase and ornithine aminotransferase genes in the mouse liver.
Molecular and cellular biology 1991;11(12):6050-8.
1991: Kuo F C; Hwu W L; Valle D; Darnell J E
Colocalization in pericentral hepatocytes in adult mice and similarity in developmental expression pattern of ornithine aminotransferase and glutamine synthetase mRNA.
Proceedings of the National Academy of Sciences of the United States of America 1991;88(21):9468-72.
1991: Decker T; Lew D J; Darnell J E
Two distinct alpha-interferon-dependent signal transduction pathways may contribute to activation of transcription of the guanylate-binding protein gene.
Molecular and cellular biology 1991;11(10):5147-53.
1991: Xanthopoulos K G; Prezioso V R; Chen W S; Sladek F M; Cortese R; Darnell J E
The different tissue transcription patterns of genes for HNF-1, C/EBP, HNF-3, and HNF-4, protein factors that govern liver-specific transcription.
Proceedings of the National Academy of Sciences of the United States of America 1991;88(9):3807-11.
1991: Decker T; Lew D J; Mirkovitch J; Darnell J E
Cytoplasmic activation of GAF, an IFN-gamma-regulated DNA-binding factor.
The EMBO journal 1991;10(4):927-32.
1991: Herbst R S; Nielsch U; Sladek F; Lai E; Babiss L E; Darnell J E
Differential regulation of hepatocyte-enriched transcription factors explains changes in albumin and transthyretin gene expression among hepatoma cells.
The New biologist 1991;3(3):289-96.
1991: Lai E; Prezioso V R; Tao W F; Chen W S; Darnell J E
Hepatocyte nuclear factor 3 alpha belongs to a gene family in mammals that is homologous to the Drosophila homeotic gene fork head.
Genes & development 1991;5(3):416-27.
1991: Mirkovitch J; Darnell J E
Rapid in vivo footprinting technique identifies proteins bound to the TTR gene in the mouse liver.
Genes & development 1991;5(1):83-93.
1991: Lew D J; Decker T; Strehlow I; Darnell J E
Overlapping elements in the guanylate-binding protein gene promoter mediate transcriptional induction by alpha and gamma interferons.
Molecular and cellular biology 1991;11(1):182-91.
1990: Sladek F M; Zhong W M; Lai E; Darnell J E
Liver-enriched transcription factor HNF-4 is a novel member of the steroid hormone receptor superfamily.
Genes & development 1990;4(12B):2353-65.
1990: Fu X Y; Kessler D S; Veals S A; Levy D E; Darnell J E
ISGF3, the transcriptional activator induced by interferon alpha, consists of multiple interacting polypeptide chains.
Proceedings of the National Academy of Sciences of the United States of America 1990;87(21):8555-9.
1990: Levy D; Darnell J E
Interferon-dependent transcriptional activation: signal transduction without second messenger involvement?
The New biologist 1990;2(10):923-8.
1990: Herbst R S; Boczko E M; Darnell J E; Babiss L E
The mouse albumin enhancer contains a negative regulatory element that interacts with a novel DNA-binding protein.
Molecular and cellular biology 1990;10(8):3896-905.
1990: Lai E; Prezioso V R; Smith E; Litvin O; Costa R H; Darnell J E
HNF-3A, a hepatocyte-enriched transcription factor of novel structure is regulated transcriptionally.
Genes & development 1990;4(8):1427-36.
1990: Kuo C F; Xanthopoulos K G; Darnell J E
Fetal and adult localization of C/EBP: evidence for combinatorial action of transcription factors in cell-specific gene expression.
Development (Cambridge, England) 1990;109(2):473-81.
1990: Pine R; Decker T; Kessler D S; Levy D E; Darnell J E
Purification and cloning of interferon-stimulated gene factor 2 (ISGF2): ISGF2 (IRF-1) can bind to the promoters of both beta interferon- and interferon-stimulated genes but is not a primary transcriptional activator of either.
Molecular and cellular biology 1990;10(6):2448-57.
1990: Paulson K E; Darnell J E; Rushmore T; Pickett C B
Analysis of the upstream elements of the xenobiotic compound-inducible and positionally regulated glutathione S-transferase Ya gene.
Molecular and cellular biology 1990;10(5):1841-52.
1990: Levy D E; Lew D J; Decker T; Kessler D S; Darnell J E
Synergistic interaction between interferon-alpha and interferon-gamma through induced synthesis of one subunit of the transcription factor ISGF3.
The EMBO journal 1990;9(4):1105-11.
1989: Lew D J; Decker T; Darnell J E
Alpha interferon and gamma interferon stimulate transcription of a single gene through different signal transduction pathways.
Molecular and cellular biology 1989;9(12):5404-11.
1989: Levy D E; Kessler D S; Pine R; Darnell J E
Cytoplasmic activation of ISGF3, the positive regulator of interferon-alpha-stimulated transcription, reconstituted in vitro.
Genes & development 1989;3(9):1362-71.
1989: Pine R; Darnell J E
In vivo evidence of interaction between interferon-stimulated gene factors and the interferon-stimulated response element.
Molecular and cellular biology 1989;9(8):3533-7.
1989: Decker T; Lew D J; Cheng Y S; Levy D E; Darnell J E
Interactions of alpha- and gamma-interferon in the transcriptional regulation of the gene encoding a guanylate-binding protein.
The EMBO journal 1989;8(7):2009-14.
1989: Kuo C F; Darnell J E
Mouse glutamine synthetase is encoded by a single gene that can be expressed in a localized fashion.
Journal of molecular biology 1989;208(1):45-56.
1989: Xanthopoulos K G; Mirkovitch J; Decker T; Kuo C F; Darnell J E
Cell-specific transcriptional control of the mouse DNA-binding protein mC/EBP.
Proceedings of the National Academy of Sciences of the United States of America 1989;86(11):4117-21.
1989: Reich N C; Darnell J E
Differential binding of interferon-induced factors to an oligonucleotide that mediates transcriptional activation.
Nucleic acids research 1989;17(9):3415-24.
1989: Costa R H; Grayson D R; Darnell J E
Multiple hepatocyte-enriched nuclear factors function in the regulation of transthyretin and alpha 1-antitrypsin genes.
Molecular and cellular biology 1989;9(4):1415-25.
1989: Herbst R S; Friedman N; Darnell J E; Babiss L E
Positive and negative regulatory elements in the mouse albumin enhancer.
Proceedings of the National Academy of Sciences of the United States of America 1989;86(5):1553-7.
1989: Vales L D; Darnell J E
Promoter occlusion prevents transcription of adenovirus polypeptide IX mRNA until after DNA replication.
Genes & development 1989;3(1):49-59.
1989: Xanthopoulos K G; Mirkovitch J; Friedman J M; Darnell J E
The mouse Cebp gene encoding a DNA-binding protein is polymorphic and is located on chromosome 7.
Cytogenetics and cell genetics 1989;50(2-3):174-5.
1988: Kessler D S; Pine R; Pfeffer L M; Levy D E; Darnell J E
Cells resistant to interferon are defective in activation of a promoter-binding factor.
The EMBO journal 1988;7(12):3779-83.
1988: Kuo C F; Paulson K E; Darnell J E
Positional and developmental regulation of glutamine synthetase expression in mouse liver.
Molecular and cellular biology 1988;8(11):4966-71.
1988: Kessler D S; Levy D E; Darnell J E
Two interferon-induced nuclear factors bind a single promoter element in interferon-stimulated genes.
Proceedings of the National Academy of Sciences of the United States of America 1988;85(22):8521-5.
1988: Costa R H; Grayson D R; Xanthopoulos K G; Darnell J E
A liver-specific DNA-binding protein recognizes multiple nucleotide sites in regulatory regions of transthyretin, alpha 1-antitrypsin, albumin, and simian virus 40 genes.
Proceedings of the National Academy of Sciences of the United States of America 1988;85(11):3840-4.
1988: Levy D E; Kessler D S; Pine R; Reich N; Darnell J E
Interferon-induced nuclear factors that bind a shared promoter element correlate with positive and negative transcriptional control.
Genes & development 1988;2(4):383-93.
1988: Grayson D R; Costa R H; Xanthopoulos K G; Darnell J E
A cell-specific enhancer of the mouse alpha 1-antitrypsin gene has multiple functional regions and corresponding protein-binding sites.
Molecular and cellular biology 1988;8(3):1055-66.
1988: Grayson D R; Costa R H; Xanthopoulos K G; Darnell J E
One factor recognizes the liver-specific enhancers in alpha 1-antitrypsin and transthyretin genes.
Science (New York, N.Y.) 1988;239(4841 Pt 1):786-8.
1988: Pine R; Levy D E; Reich N; Darnell J E
Transcriptional stimulation by CaPO4-DNA precipitates.
Nucleic acids research 1988;16(4):1371-8.
1988: Costa R H; Lai E; Grayson D R; Darnell J E
The cell-specific enhancer of the mouse transthyretin (prealbumin) gene binds a common factor at one site and a liver-specific factor(s) at two other sites.
Molecular and cellular biology 1988;8(1):81-90.
1988: Reich N; Pine R; Levy D; Darnell J E
Transcription of interferon-stimulated genes is induced by adenovirus particles but is suppressed by E1A gene products.
Journal of virology 1988;62(1):114-9.
1988: Levy D; Reich N; Kessler D; Pine R; Darnell J E
Transcriptional regulation of interferon-stimulated genes: a DNA response element and induced proteins that recognize it.
Cold Spring Harbor symposia on quantitative biology 1988;53 Pt 2():799-802.
1987: Bennett A L; Paulson K E; Miller R E; Darnell J E
Acquisition of antigens characteristic of adult pericentral hepatocytes by differentiating fetal hepatoblasts in vitro.
The Journal of cell biology 1987;105(3):1073-85.
1987: Babiss L E; Herbst R S; Bennett A L; Darnell J E
Factors that interact with the rat albumin promoter are present both in hepatocytes and other cell types.
Genes & development 1987;1(3):256-67.
1982: Salditt-Georgieff M; Darnell J E
Further evidence that the majority of primary nuclear RNA transcripts in mammalian cells do not contribute to mRNA.
Molecular and cellular biology 1982;2(6):701-7.
1981: Harpold M M; Wilson M C; Darnell J E
Chinese hamster polyadenylated messenger ribonucleic acid: relationship to non-polyadenylated sequences and relative conservation during messenger ribonucleic acid processing.
Molecular and cellular biology 1981;1(2):188-98.
1981: Salditt-Georgieff M; Harpold M M; Wilson M C; Darnell J E
Large heterogeneous nuclear ribonucleic acid has three times as many 5' caps as polyadenylic acid segments, and most caps do not enter polyribosomes.
Molecular and cellular biology 1981;1(2):179-87.
1980: Salditt-Georgieff M; Harpold M; Sawicki S; Nevins J; Darnell J E
Addition of poly(A) to nuclear RNA occurs soon after RNA synthesis.
The Journal of cell biology 1980;86(3):844-8.
1980: Salditt-Georgieff M; Harpold M; Chen-Kiang S; Darnell J E
The addition of 5' cap structures occurs early in hnRNA synthesis and prematurely terminated molecules are capped.
Cell 1980;19(1):69-78.

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