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Robert Darnell

This is a preview profile on BiomedExperts - the first literature-based scientific social network. It brings the right researchers together and allows them to collaborate online. Collexis and Dell provide the BiomedExperts network of +1.5 Million pre-calculated profiles free of charge to researchers worldwide.

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Co-Publications
Name
10
Albert, Matthew
9
Darnell, Jennifer
9
Ule, Jernej
8
Posner, Jerome
6
Ruggiu, Matteo
6
Stefani, Giovanni
5
Yang, YY
5
Blachère, Nathalie
5
Buckanovich, Ronald
5
Jensen, Kirk
5
Mele, Aldo
5
Musunuru, Kiran
4
Dredge, Kate
4
Roberts, Wendy
3
Lewis, Hal

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Publications

TOP 3
Darnell Jennifer C; Fraser Claire E; Mostovetsky Olga; Darnell Robert B
Discrimination of common and unique RNA-binding activities among Fragile X mental retardation protein paralogs.
Hou Yafei; DeVoss Jason; Dao Vinh; Kwek Serena; Simko Jeffrey P; McNeel Douglas G; Anderson Mark S; Fong Lawrence
An aberrant prostate antigen-specific immune response causes prostatitis in mice and is associated with chronic prostatitis in humans.
Chi Sung Wook; Zang Julie B; Mele Aldo; Darnell Robert B
Argonaute HITS-CLIP decodes microRNA-mRNA interaction maps.

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All Publications

2009: Darnell Jennifer C; Fraser Claire E; Mostovetsky Olga; Darnell Robert B
Discrimination of common and unique RNA-binding activities among Fragile X mental retardation protein paralogs.
Human molecular genetics 2009;18(17):3164-77.
2009: Hou Yafei; DeVoss Jason; Dao Vinh; Kwek Serena; Simko Jeffrey P; McNeel Douglas G; Anderson Mark S; Fong Lawrence
An aberrant prostate antigen-specific immune response causes prostatitis in mice and is associated with chronic prostatitis in humans.
The Journal of clinical investigation 2009;119(7):2031-41.
2009: Chi Sung Wook; Zang Julie B; Mele Aldo; Darnell Robert B
Argonaute HITS-CLIP decodes microRNA-mRNA interaction maps.
Nature 2009;460(7254):479-86.
2009: Roberts Wendy K; Deluca Ilana J; Thomas Ashby; Fak John; Williams Travis; Buckley Noreen; Dousmanis Athanasios G; Posner Jerome B; Darnell Robert B
Patients with lung cancer and paraneoplastic Hu syndrome harbor HuD-specific type 2 CD8+ T cells.
The Journal of clinical investigation 2009;119(7):2042-51.
2009: Ruggiu Matteo; Herbst Ruth; Kim Natalie; Jevsek Marko; Fak John J; Mann Mary Anne; Fischbach Gerald; Burden Steven J; Darnell Robert B
Rescuing Z+ agrin splicing in Nova null mice restores synapse formation and unmasks a physiologic defect in motor neuron firing.
Proceedings of the National Academy of Sciences of the United States of America 2009;106(9):3513-8.
2009: DeLuca Ilana; Blachère Nathalie E; Santomasso Bianca; Darnell Robert B
Tolerance to the neuron-specific paraneoplastic HuD antigen.
PloS one 2009;4(6):e5739.
2008: Licatalosi Donny D; Mele Aldo; Fak John J; Ule Jernej; Kayikci Melis; Chi Sung Wook; Clark Tyson A; Schweitzer Anthony C; Blume John E; Wang Xuning; Darnell Jennifer C; Darnell Robert B
HITS-CLIP yields genome-wide insights into brain alternative RNA processing.
Nature 2008;456(7221):464-9.
2007: Santomasso Bianca D; Roberts Wendy K; Thomas Ashby; Williams Travis; Blachère Nathalie E; Dudley Mark E; Houghton Alan N; Posner Jerome B; Darnell Robert B
A T-cell receptor associated with naturally occurring human tumor immunity.
Proceedings of the National Academy of Sciences of the United States of America 2007;104(48):19073-8.
2007: Jelen Nejc; Ule Jernej; Zivin Marko; Darnell Robert B
Evolution of Nova-dependent splicing regulation in the brain.
PLoS genetics 2007;3(10):1838-47.
2007: Longman Randy S; Braun Deborah; Pellegrini Sandra; Rice Charles M; Darnell Robert B; Albert Matthew L
Dendritic-cell maturation alters intracellular signaling networks, enabling differential effects of IFN-alpha/beta on antigen cross-presentation.
Blood 2007;109(3):1113-22.
2007: Ule Jernej; Darnell Robert B
Functional and mechanistic insights from genome-wide studies of splicing regulation in the brain.
Advances in experimental medicine and biology 2007;623():148-60.
2006: Ule Jernej; Stefani Giovanni; Mele Aldo; Ruggiu Matteo; Wang Xuning; Taneri Bahar; Gaasterland Terry; Blencowe Benjamin J; Darnell Robert B
An RNA map predicting Nova-dependent splicing regulation.
Nature 2006;444(7119):580-6.
2006: Licatalosi Donny D; Darnell Robert B
Splicing regulation in neurologic disease.
Neuron 2006;52(1):93-101.
2006: Darnell Robert B; Posner Jerome B
Paraneoplastic syndromes affecting the nervous system.
Seminars in oncology 2006;33(3):270-98.
2006: Blachère Nathalie E; Morris Heather K; Braun Deborah; Saklani Hélène; Di Santo James P; Darnell Robert B; Albert Matthew L
IL-2 is required for the activation of memory CD8+ T cells via antigen cross-presentation.
Journal of immunology (Baltimore, Md. : 1950) 2006;176(12):7288-300.
2006: Ule Jernej; Darnell Robert B
RNA binding proteins and the regulation of neuronal synaptic plasticity.
Current opinion in neurobiology 2006;16(1):102-10.
2005: Ule Jernej; Jensen Kirk; Mele Aldo; Darnell Robert B
CLIP: a method for identifying protein-RNA interaction sites in living cells.
Methods (San Diego, Calif.) 2005;37(4):376-86.
2005: Huang Cindy Shen; Shi Song-Hai; Ule Jernej; Ruggiu Matteo; Barker Laura A; Darnell Robert B; Jan Yuh Nung; Jan Lily Yeh
Common molecular pathways mediate long-term potentiation of synaptic excitation and slow synaptic inhibition.
Cell 2005;123(1):105-18.
2005: Darnell J C; Mostovetsky O; Darnell R B
FMRP RNA targets: identification and validation.
Genes, brain, and behavior 2005;4(6):341-9.
2005: Ule Jernej; Ule Aljaz; Spencer Joanna; Williams Alan; Hu Jing-Shan; Cline Melissa; Wang Hui; Clark Tyson; Fraser Claire; Ruggiu Matteo; Zeeberg Barry R; Kane David; Weinstein John N; Blume John; Darnell Robert B
Nova regulates brain-specific splicing to shape the synapse.
Nature genetics 2005;37(8):844-52.
2005: Darnell Robert B; Posner Jerome B
A new cause of limbic encephalopathy.
Brain : a journal of neurology 2005;128(Pt 8):1745-6.
2005: Blachère Nathalie E; Darnell Robert B; Albert Matthew L
Apoptotic cells deliver processed antigen to dendritic cells for cross-presentation.
PLoS biology 2005;3(6):e185.
2005: Dredge B Kate; Stefani Giovanni; Engelhard Caitlin C; Darnell Robert B
Nova autoregulation reveals dual functions in neuronal splicing.
The EMBO journal 2005;24(8):1608-20.
2005: Darnell Jennifer C; Fraser Claire E; Mostovetsky Olga; Stefani Giovanni; Jones Thomas A; Eddy Sean R; Darnell Robert B
Kissing complex RNAs mediate interaction between the Fragile-X mental retardation protein KH2 domain and brain polyribosomes.
Genes & development 2005;19(8):903-18.
2005: Relógio Angela; Ben-Dov Claudia; Baum Michael; Ruggiu Matteo; Gemund Christine; Benes Vladimir; Darnell Robert B; Valcárcel Juan
Alternative splicing microarrays reveal functional expression of neuron-specific regulators in Hodgkin lymphoma cells.
The Journal of biological chemistry 2005;280(6):4779-84.
2004: Roberts Wendy K; Darnell Robert B
Neuroimmunology of the paraneoplastic neurological degenerations.
Current opinion in immunology 2004;16(5):616-22.
2004: Stefani Giovanni; Fraser Claire E; Darnell Jennifer C; Darnell Robert B
Fragile X mental retardation protein is associated with translating polyribosomes in neuronal cells.
The Journal of neuroscience : the official journal of the Society for Neuroscience 2004;24(33):7272-6.
2004: Darnell Robert B
Paraneoplastic neurologic disorders: windows into neuronal function and tumor immunity.
Archives of neurology 2004;61(1):30-2.
2004: Albert Matthew L; Darnell Robert B
Paraneoplastic neurological degenerations: keys to tumour immunity.
Nature reviews. Cancer 2004;4(1):36-44.
2004: Musunuru Kiran; Darnell Robert B
Determination and augmentation of RNA sequence specificity of the Nova K-homology domains.
Nucleic acids research 2004;32(16):4852-61.
2004: Orange D E; Jegathesan M; Blachère N E; Frank M O; Scher H I; Albert M L; Darnell R B
Effective antigen cross-presentation by prostate cancer patients' dendritic cells: implications for prostate cancer immunotherapy.
Prostate cancer and prostatic diseases 2004;7(1):63-72.
2004: Darnell Jennifer C; Warren Stephen T; Darnell Robert B
The fragile X mental retardation protein, FMRP, recognizes G-quartets.
Mental retardation and developmental disabilities research reviews 2004;10(1):49-52.
2003: Darnell Robert B
Memory, synaptic translation, and...prions?
Cell 2003;115(7):767-8.
2003: Ule Jernej; Jensen Kirk B; Ruggiu Matteo; Mele Aldo; Ule Aljaz; Darnell Robert B
CLIP identifies Nova-regulated RNA networks in the brain.
Science (New York, N.Y.) 2003;302(5648):1212-5.
2003: Darnell Robert B; Posner Jerome B
Paraneoplastic syndromes involving the nervous system.
The New England journal of medicine 2003;349(16):1543-54.
2003: Dredge B Kate; Darnell Robert B
Nova regulates GABA(A) receptor gamma2 alternative splicing via a distal downstream UCAU-rich intronic splicing enhancer.
Molecular and cellular biology 2003;23(13):4687-700.
2003: Darnell Robert B; Posner Jerome B
Observing the invisible: successful tumor immunity in humans.
Nature immunology 2003;4(3):201.
2002: Darnell Robert B
RNA logic in time and space.
Cell 2002;110(5):545-50.
2002: Ito Mitsuhiro; Okano Hirotaka J; Darnell Robert B; Roeder Robert G
The TRAP100 component of the TRAP/Mediator complex is essential in broad transcriptional events and development.
The EMBO journal 2002;21(13):3464-75.
2001: Darnell J C; Jensen K B; Jin P; Brown V; Warren S T; Darnell R B
Fragile X mental retardation protein targets G quartet mRNAs important for neuronal function.
Cell 2001;107(4):489-99.
2001: Albert M L; Jegathesan M; Darnell R B
Dendritic cell maturation is required for the cross-tolerization of CD8+ T cells.
Nature immunology 2001;2(11):1010-7.
2001: Dredge B K; Polydorides A D; Darnell R B
The splice of life: alternative splicing and neurological disease.
Nature reviews. Neuroscience 2001;2(1):43-50.
2001: Musunuru K; Darnell R B
Paraneoplastic neurologic disease antigens: RNA-binding proteins and signaling proteins in neuronal degeneration.
Annual review of neuroscience 2001;24():239-62.
2000: Darnell R B; Albert M L
cdr2-specific CTLs are detected in the blood of all patients with paraneoplastic cerebellar degeneration analyzed.
Annals of neurology 2000;48(2):270-1.
2000: Polydorides A D; Okano H J; Yang Y Y; Stefani G; Darnell R B
A brain-enriched polypyrimidine tract-binding protein antagonizes the ability of Nova to regulate neuron-specific alternative splicing.
Proceedings of the National Academy of Sciences of the United States of America 2000;97(12):6350-5.
2000: Jensen K B; Musunuru K; Lewis H A; Burley S K; Darnell R B
The tetranucleotide UCAY directs the specific recognition of RNA by the Nova K-homology 3 domain.
Proceedings of the National Academy of Sciences of the United States of America 2000;97(11):5740-5.
2000: Ito M; Yuan C X; Okano H J; Darnell R B; Roeder R G
Involvement of the TRAP220 component of the TRAP/SMCC coactivator complex in embryonic development and thyroid hormone action.
Molecular cell 2000;5(4):683-93.
2000: Darnell J C; Albert M L; Darnell R B
Cdr2, a target antigen of naturally occuring human tumor immunity, is widely expressed in gynecological tumors.
Cancer research 2000;60(8):2136-9.
2000: Jensen K B; Dredge B K; Stefani G; Zhong R; Buckanovich R J; Okano H J; Yang Y Y; Darnell R B
Nova-1 regulates neuron-specific alternative splicing and is essential for neuronal viability.
Neuron 2000;25(2):359-71.
2000: Lewis H A; Musunuru K; Jensen K B; Edo C; Chen H; Darnell R B; Burley S K
Sequence-specific RNA binding by a Nova KH domain: implications for paraneoplastic disease and the fragile X syndrome.
Cell 2000;100(3):323-32.
2000: Albert M L; Austin L M; Darnell R B
Detection and treatment of activated T cells in the cerebrospinal fluid of patients with paraneoplastic cerebellar degeneration.
Annals of neurology 2000;47(1):9-17.
1999: Okano H J; Park W Y; Corradi J P; Darnell R B
The cytoplasmic Purkinje onconeural antigen cdr2 down-regulates c-Myc function: implications for neuronal and tumor cell survival.
Genes & development 1999;13(16):2087-97.
1999: Lewis H A; Chen H; Edo C; Buckanovich R J; Yang Y Y; Musunuru K; Zhong R; Darnell R B; Burley S K
Crystal structures of Nova-1 and Nova-2 K-homology RNA-binding domains.
Structure (London, England : 1993) 1999;7(2):191-203.
1998: Darnell R B
Immunologic complexity in neurons.
Neuron 1998;21(5):947-50.
1998: Albert M L; Darnell J C; Bender A; Francisco L M; Bhardwaj N; Darnell R B
Tumor-specific killer cells in paraneoplastic cerebellar degeneration.
Nature medicine 1998;4(11):1321-4.
1998: Yang Y Y; Yin G L; Darnell R B
The neuronal RNA-binding protein Nova-2 is implicated as the autoantigen targeted in POMA patients with dementia.
Proceedings of the National Academy of Sciences of the United States of America 1998;95(22):13254-9.
1997: Fletcher C F; Okano H J; Gilbert D J; Yang Y; Yang C; Copeland N G; Jenkins N A; Darnell R B
Mouse chromosomal locations of nine genes encoding homologs of human paraneoplastic neurologic disorder antigens.
Genomics 1997;45(2):313-9.
1997: Fei H; Okano H J; Li C; Lee G H; Zhao C; Darnell R; Friedman J M
Anatomic localization of alternatively spliced leptin receptors (Ob-R) in mouse brain and other tissues.
Proceedings of the National Academy of Sciences of the United States of America 1997;94(13):7001-5.
1997: Buckanovich R J; Darnell R B
The neuronal RNA binding protein Nova-1 recognizes specific RNA targets in vitro and in vivo.
Molecular and cellular biology 1997;17(6):3194-201.
1997: Okano H J; Darnell R B
A hierarchy of Hu RNA binding proteins in developing and adult neurons.
The Journal of neuroscience : the official journal of the Society for Neuroscience 1997;17(9):3024-37.
1997: Corradi J P; Yang C; Darnell J C; Dalmau J; Darnell R B
A post-transcriptional regulatory mechanism restricts expression of the paraneoplastic cerebellar degeneration antigen cdr2 to immune privileged tissues.
The Journal of neuroscience : the official journal of the Society for Neuroscience 1997;17(4):1406-15.
1996: Simpson F; Bright N A; West M A; Newman L S; Darnell R B; Robinson M S
A novel adaptor-related protein complex.
The Journal of cell biology 1996;133(4):749-60.
1996: Darnell R B
Onconeural antigens and the paraneoplastic neurologic disorders: at the intersection of cancer, immunity, and the brain.
Proceedings of the National Academy of Sciences of the United States of America 1996;93(10):4529-36.
1996: Buckanovich R J; Yang Y Y; Darnell R B
The onconeural antigen Nova-1 is a neuron-specific RNA-binding protein, the activity of which is inhibited by paraneoplastic antibodies.
The Journal of neuroscience : the official journal of the Society for Neuroscience 1996;16(3):1114-22.
1995: Newman L S; McKeever M O; Okano H J; Darnell R B
Beta-NAP, a cerebellar degeneration antigen, is a neuron-specific vesicle coat protein.
Cell 1995;82(5):773-83.
1993: Buckanovich R J; Posner J B; Darnell R B
Nova, the paraneoplastic Ri antigen, is homologous to an RNA-binding protein and is specifically expressed in the developing motor system.
Neuron 1993;11(4):657-72.
1993: Darnell R B
The polymerase chain reaction: application to nervous system disease.
Annals of neurology 1993;34(4):513-23.

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