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Robert Darnell

Research Profile

Chemicals & Drugs

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Dana E Orange; Salina Parveen; Suyan Tian; Nathalie E Blachere; John Fak; Mayu O Frank; Margo Herre; Sebastien Monette; Robert B Darnell
Dendritic cells loaded with FK506 kill T cells in an antigen-specific manner and prevent autoimmunity in vivo.
Taesun Eom; John Fak; Kenneth Lay; Jeffrey L Noebels; Huidong Wang; Chaolin Zhang; Robert B Darnell
NOVA-dependent regulation of cryptic NMD exons controls synaptic protein levels after seizure.
Gulayse Ince-Dunn; Kirk B Jensen; Aldo Mele; Jeffrey L Noebels; Hideyuki Okano; Hirotaka J Okano; Woong-Yang Park; Jernej Ule; Chingwen Yang; Jong Yoo; Chaolin Zhang; Ru Zhong; John Fak; Margaret Herre; Robert B Darnell
Neuronal Elav-like (Hu) proteins regulate RNA splicing and abundance to control glutamate levels and neuronal excitability.

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All Publications

2013: Dana E Orange; Salina Parveen; Suyan Tian; Nathalie E Blachere; John Fak; Mayu O Frank; Margo Herre; Sebastien Monette; Robert B Darnell
Dendritic cells loaded with FK506 kill T cells in an antigen-specific manner and prevent autoimmunity in vivo.
eLife 2013;2():e00105.
2013: Taesun Eom; John Fak; Kenneth Lay; Jeffrey L Noebels; Huidong Wang; Chaolin Zhang; Robert B Darnell
NOVA-dependent regulation of cryptic NMD exons controls synaptic protein levels after seizure.
eLife 2013;2():e00178.
2012: Gulayse Ince-Dunn; Kirk B Jensen; Aldo Mele; Jeffrey L Noebels; Hideyuki Okano; Hirotaka J Okano; Woong-Yang Park; Jernej Ule; Chingwen Yang; Jong Yoo; Chaolin Zhang; Ru Zhong; John Fak; Margaret Herre; Robert B Darnell
Neuronal Elav-like (Hu) proteins regulate RNA splicing and abundance to control glutamate levels and neuronal excitability.
Neuron 2012;75(6):1067-80.
2012: Donny D Licatalosi; Aldo Mele; Masato Yano; Chaolin Zhang; John Fak; Sarah E Grabinski; Robert B Darnell
Ptbp2 represses adult-specific splicing to regulate the generation of neuronal precursors in the embryonic brain.
Genes & development 2012;26(14):1626-42.
2012: Sung Wook Chi; Gregory J Hannon; Robert B Darnell
An alternative mode of microRNA target recognition.
Nature structural & molecular biology 2012;19(3):321-7.
2011: Jennifer C Darnell; Cynthia Chen; Sung Wook Chi; John Fak; Claire E Fraser; Ka Ying Sharon Hung; Donny D Licatalosi; Aldo Mele; Joel D Richter; Elizabeth F Stone; Sarah J Van Driesche; Chaolin Zhang; Robert B Darnell
FMRP stalls ribosomal translocation on mRNAs linked to synaptic function and autism.
Cell 2011;146(2):247-61.
2011: Chaolin Zhang; Robert B Darnell
Mapping in vivo protein-RNA interactions at single-nucleotide resolution from HITS-CLIP data.
Nature biotechnology 2011;29(7):607-14.
2010: Robert B Darnell
HITS-CLIP: panoramic views of protein-RNA regulation in living cells.
Wiley interdisciplinary reviews. RNA 2010;1(2):266-86.
2010: Robert B Darnell
RNA regulation in neurologic disease and cancer.
Cancer research and treatment : official journal of Korean Cancer Association 2010;42(3):125-9.
2010: Chaolin Zhang; Maria A Frias; Aldo Mele; Matteo Ruggiu; Taesun Eom; Christina B Marney; Huidong Wang; Donny D Licatalosi; John J Fak; Robert B Darnell
Integrative modeling defines the Nova splicing-regulatory network and its combinatorial controls.
Science (New York, N.Y.) 2010;329(5990):439-43.
2010: Masato Yano; Yoshika Hayakawa-Yano; Aldo Mele; Robert B Darnell
Nova2 regulates neuronal migration through an RNA switch in disabled-1 signaling.
Neuron 2010;66(6):848-58.
2010: Mayu O Frank; Julia Kaufman; Suyan Tian; Mayte Suárez-Fariñas; Salina Parveen; Nathalie E Blachère; Michael J Morris; Susan F Slovin; Howard I Scher; Matthew L Albert; Robert B Darnell
Harnessing naturally occurring tumor immunity: a clinical vaccine trial in prostate cancer.
PloS one 2010;5(9):.
2010: Kevin J O'Donovan; Jennifer Diedler; Graeme C Couture; John Fak; Robert B Darnell
The onconeural antigen cdr2 is a novel APC/C target that acts in mitosis to regulate c-myc target genes in mammalian tumor cells.
PloS one 2010;5(4):e10045.
2010: Donny D Licatalosi; Robert B Darnell
RNA processing and its regulation: global insights into biological networks.
Nature reviews. Genetics 2010;11(1):75-87.
2009: Julie B Zang; Elena D Nosyreva; Corinne M Spencer; Lenora J Volk; Kiran Musunuru; Ru Zhong; Elizabeth F Stone; Lisa A Yuva-Paylor; Kimberly M Huber; Richard Paylor; Jennifer C Darnell; Robert B Darnell
A mouse model of the human Fragile X syndrome I304N mutation.
PLoS genetics 2009;5(12):e1000758.
2009: Jennifer C Darnell; Claire E Fraser; Olga Mostovetsky; Robert B Darnell
Discrimination of common and unique RNA-binding activities among Fragile X mental retardation protein paralogs.
Human molecular genetics 2009;18(17):3164-77.
2009: Sung Wook Chi; Julie B Zang; Aldo Mele; Robert B Darnell
Argonaute HITS-CLIP decodes microRNA-mRNA interaction maps.
Nature 2009;460(7254):479-86.
2009: Wendy K Roberts; Ilana J Deluca; Ashby Thomas; John Fak; Travis Williams; Noreen Buckley; Athanasios G Dousmanis; Jerome B Posner; Robert B Darnell
Patients with lung cancer and paraneoplastic Hu syndrome harbor HuD-specific type 2 CD8+ T cells.
The Journal of clinical investigation 2009;119(7):2042-51.
2009: Matteo Ruggiu; Ruth Herbst; N Kim; Marko Jevsek; John Fak; Mary Anne Mann; Gerald Fischbach; Steven J Burden; Robert B Darnell
Rescuing Z+ agrin splicing in Nova null mice restores synapse formation and unmasks a physiologic defect in motor neuron firing.
Proceedings of the National Academy of Sciences of the United States of America 2009;106(9):3513-8.
2009: Ilana DeLuca; Nathalie E Blachère; Bianca Santomasso; Robert B Darnell
Tolerance to the neuron-specific paraneoplastic HuD antigen.
PloS one 2009;4(6):e5739.
2008: Donny D Licatalosi; Aldo Mele; John J Fak; Jernej Ule; Melis Kayikci; Sung Wook Chi; Tyson A Clark; Anthony C Schweitzer; John E Blume; Xuning Wang; Jennifer C Darnell; Robert B Darnell
HITS-CLIP yields genome-wide insights into brain alternative RNA processing.
Nature 2008;456(7221):464-9.
2007: Bianca D Santomasso; Wendy K Roberts; Ashby Thomas; Travis Williams; Nathalie E Blachère; Mark E Dudley; Alan N Houghton; Jerome B Posner; Robert B Darnell
A T-cell receptor associated with naturally occurring human tumor immunity.
Proceedings of the National Academy of Sciences of the United States of America 2007;104(48):19073-8.
2007: Nejc Jelen; Jernej Ule; Marko Zivin; Robert B Darnell
Evolution of Nova-dependent splicing regulation in the brain.
PLoS genetics 2007;3(10):1838-47.
2007: Randy S Longman; Deborah Braun; Sandra Pellegrini; Charles M Rice; Robert B Darnell; Matthew L Albert
Dendritic-cell maturation alters intracellular signaling networks, enabling differential effects of IFN-alpha/beta on antigen cross-presentation.
Blood 2007;109(3):1113-22.
2007: Jernej Ule; Robert B Darnell
Functional and mechanistic insights from genome-wide studies of splicing regulation in the brain.
Advances in experimental medicine and biology 2007;623():148-60.
2006: Jernej Ule; Giovanni Stefani; Aldo Mele; Matteo Ruggiu; Xuning Wang; Bahar Taneri; Terry Gaasterland; Benjamin J Blencowe; Robert B Darnell
An RNA map predicting Nova-dependent splicing regulation.
Nature 2006;444(7119):580-6.
2006: Donny D Licatalosi; Robert B Darnell
Splicing regulation in neurologic disease.
Neuron 2006;52(1):93-101.
2006: Nathalie E Blachère; Heather K Morris; Deborah Braun; Hélène Saklani; James P Di Santo; Robert B Darnell; Matthew L Albert
IL-2 is required for the activation of memory CD8+ T cells via antigen cross-presentation.
Journal of immunology (Baltimore, Md. : 1950) 2006;176(12):7288-300.
2006: Robert B Darnell; Jerome B Posner
Paraneoplastic syndromes affecting the nervous system.
Seminars in oncology 2006;33(3):270-98.
2006: Jernej Ule; Robert B Darnell
RNA binding proteins and the regulation of neuronal synaptic plasticity.
Current opinion in neurobiology 2006;16(1):102-10.
2005: Jernej Ule; Kirk Jensen; Aldo Mele; Robert B Darnell
CLIP: a method for identifying protein-RNA interaction sites in living cells.
Methods (San Diego, Calif.) 2005;37(4):376-86.
2005: Cindy Shen Huang; Song-Hai Shi; Jernej Ule; Matteo Ruggiu; Laura A Barker; Robert B Darnell; Yuh Nung Jan; Lily Yeh Jan
Common molecular pathways mediate long-term potentiation of synaptic excitation and slow synaptic inhibition.
Cell 2005;123(1):105-18.
2005: Jennifer C Darnell; O Mostovetsky; Robert B Darnell
FMRP RNA targets: identification and validation.
Genes, brain, and behavior 2005;4(6):341-9.
2005: Jernej Ule; Aljaz Ule; Joanna Spencer; Alan Williams; Jing-Shan Hu; Melissa Cline; Hui Wang; Tyson Clark; Claire Fraser; Matteo Ruggiu; Barry R Zeeberg; David Kane; John N Weinstein; John Blume; Robert B Darnell
Nova regulates brain-specific splicing to shape the synapse.
Nature genetics 2005;37(8):844-52.
2005: Robert B Darnell; Jerome B Posner
A new cause of limbic encephalopathy.
Brain : a journal of neurology 2005;128(Pt 8):1745-6.
2005: Nathalie E Blachère; Robert B Darnell; Matthew L Albert
Apoptotic cells deliver processed antigen to dendritic cells for cross-presentation.
PLoS biology 2005;3(6):e185.
2005: B Kate Dredge; Giovanni Stefani; Caitlin C Engelhard; Robert B Darnell
Nova autoregulation reveals dual functions in neuronal splicing.
The EMBO journal 2005;24(8):1608-20.
2005: Jennifer C Darnell; Claire E Fraser; Olga Mostovetsky; Giovanni Stefani; Thomas A Jones; Sean R Eddy; Robert B Darnell
Kissing complex RNAs mediate interaction between the Fragile-X mental retardation protein KH2 domain and brain polyribosomes.
Genes & development 2005;19(8):903-18.
2005: Angela Relógio; Claudia Ben-Dov; Michael Baum; Matteo Ruggiu; Christine Gemund; Vladimir Benes; Robert B Darnell; Juan Valcárcel
Alternative splicing microarrays reveal functional expression of neuron-specific regulators in Hodgkin lymphoma cells.
The Journal of biological chemistry 2005;280(6):4779-84.
2004: Wendy K Roberts; Robert B Darnell
Neuroimmunology of the paraneoplastic neurological degenerations.
Current opinion in immunology 2004;16(5):616-22.
2004: Giovanni Stefani; Claire E Fraser; Jennifer C Darnell; Robert B Darnell
Fragile X mental retardation protein is associated with translating polyribosomes in neuronal cells.
The Journal of neuroscience : the official journal of the Society for Neuroscience 2004;24(33):7272-6.
2004: Kiran Musunuru; Robert B Darnell
Determination and augmentation of RNA sequence specificity of the Nova K-homology domains.
Nucleic acids research 2004;32(16):4852-61.
2004: D E Orange; M Jegathesan; Nathalie E Blachère; M O Frank; Howard I Scher; Matthew L Albert; Robert B Darnell
Effective antigen cross-presentation by prostate cancer patients' dendritic cells: implications for prostate cancer immunotherapy.
Prostate cancer and prostatic diseases 2004;7(1):63-72.
2004: Jennifer C Darnell; Stephen Warren; Robert B Darnell
The fragile X mental retardation protein, FMRP, recognizes G-quartets.
Mental retardation and developmental disabilities research reviews 2004;10(1):49-52.
2004: Robert B Darnell
Paraneoplastic neurologic disorders: windows into neuronal function and tumor immunity.
Archives of neurology 2004;61(1):30-2.
2004: Matthew L Albert; Robert B Darnell
Paraneoplastic neurological degenerations: keys to tumour immunity.
Nature reviews. Cancer 2004;4(1):36-44.
2003: Robert B Darnell
Memory, synaptic translation, and...prions?
Cell 2003;115(7):767-8.
2003: Jernej Ule; Kirk B Jensen; Matteo Ruggiu; Aldo Mele; Aljaz Ule; Robert B Darnell
CLIP identifies Nova-regulated RNA networks in the brain.
Science (New York, N.Y.) 2003;302(5648):1212-5.
2003: Robert B Darnell; Jerome B Posner
Paraneoplastic syndromes involving the nervous system.
The New England journal of medicine 2003;349(16):1543-54.
2003: B Kate Dredge; Robert B Darnell
Nova regulates GABA(A) receptor gamma2 alternative splicing via a distal downstream UCAU-rich intronic splicing enhancer.
Molecular and cellular biology 2003;23(13):4687-700.
2003: Robert B Darnell; Jerome B Posner
Observing the invisible: successful tumor immunity in humans.
Nature immunology 2003;4(3):201.
2002: Robert B Darnell
RNA logic in time and space.
Cell 2002;110(5):545-50.
2002: Mitsuhiro Ito; Hirotaka J Okano; Robert B Darnell; Robert G Roeder
The TRAP100 component of the TRAP/Mediator complex is essential in broad transcriptional events and development.
The EMBO journal 2002;21(13):3464-75.
2001: Jennifer C Darnell; Kirk B Jensen; P Jin; V Brown; Stephen Warren; Robert B Darnell
Fragile X mental retardation protein targets G quartet mRNAs important for neuronal function.
Cell 2001;107(4):489-99.
2001: Matthew L Albert; M Jegathesan; Robert B Darnell
Dendritic cell maturation is required for the cross-tolerization of CD8+ T cells.
Nature immunology 2001;2(11):1010-7.
2001: Kiran Musunuru; Robert B Darnell
Paraneoplastic neurologic disease antigens: RNA-binding proteins and signaling proteins in neuronal degeneration.
Annual review of neuroscience 2001;24():239-62.
2001: B Kate Dredge; AD Polydorides; Robert B Darnell
The splice of life: alternative splicing and neurological disease.
Nature reviews. Neuroscience 2001;2(1):43-50.
2000: Robert B Darnell; Matthew L Albert
cdr2-specific CTLs are detected in the blood of all patients with paraneoplastic cerebellar degeneration analyzed.
Annals of neurology 2000;48(2):270-1.
2000: AD Polydorides; HJ Okano; YY Yang; Giovanni Stefani; Robert B Darnell
A brain-enriched polypyrimidine tract-binding protein antagonizes the ability of Nova to regulate neuron-specific alternative splicing.
Proceedings of the National Academy of Sciences of the United States of America 2000;97(12):6350-5.
2000: Kirk B Jensen; Kiran Musunuru; Hal A Lewis; Stephen K Burley; Robert B Darnell
The tetranucleotide UCAY directs the specific recognition of RNA by the Nova K-homology 3 domain.
Proceedings of the National Academy of Sciences of the United States of America 2000;97(11):5740-5.
2000: Jennifer C Darnell; Matthew L Albert; Robert B Darnell
Cdr2, a target antigen of naturally occuring human tumor immunity, is widely expressed in gynecological tumors.
Cancer research 2000;60(8):2136-9.
2000: Mitsuhiro Ito; Chao-Xing Yuan; Hirotaka J Okano; Robert B Darnell; Robert G Roeder
Involvement of the TRAP220 component of the TRAP/SMCC coactivator complex in embryonic development and thyroid hormone action.
Molecular cell 2000;5(4):683-93.
2000: Hal A Lewis; Kiran Musunuru; Kirk B Jensen; C Edo; H Chen; Robert B Darnell; Stephen K Burley
Sequence-specific RNA binding by a Nova KH domain: implications for paraneoplastic disease and the fragile X syndrome.
Cell 2000;100(3):323-32.
2000: Kirk B Jensen; B Kate Dredge; Giovanni Stefani; R Zhong; Ronald J Buckanovich; HJ Okano; YY Yang; Robert B Darnell
Nova-1 regulates neuron-specific alternative splicing and is essential for neuronal viability.
Neuron 2000;25(2):359-71.
2000: Matthew L Albert; L M Austin; Robert B Darnell
Detection and treatment of activated T cells in the cerebrospinal fluid of patients with paraneoplastic cerebellar degeneration.
Annals of neurology 2000;47(1):9-17.
1999: H J Okano; W Y Park; J P Corradi; Robert B Darnell
The cytoplasmic Purkinje onconeural antigen cdr2 down-regulates c-Myc function: implications for neuronal and tumor cell survival.
Genes & development 1999;13(16):2087-97.
1999: Hal A Lewis; H Chen; C Edo; Ronald J Buckanovich; YY Yang; Kiran Musunuru; R Zhong; Robert B Darnell; Stephen K Burley
Crystal structures of Nova-1 and Nova-2 K-homology RNA-binding domains.
Structure (London, England : 1993) 1999;7(2):191-203.
1998: Robert B Darnell
Immunologic complexity in neurons.
Neuron 1998;21(5):947-50.
1998: Matthew L Albert; Jennifer C Darnell; A Bender; LM Francisco; Nina Bhardwaj; Robert B Darnell
Tumor-specific killer cells in paraneoplastic cerebellar degeneration.
Nature medicine 1998;4(11):1321-4.
1998: YY Yang; G L Yin; Robert B Darnell
The neuronal RNA-binding protein Nova-2 is implicated as the autoantigen targeted in POMA patients with dementia.
Proceedings of the National Academy of Sciences of the United States of America 1998;95(22):13254-9.
1997: C F Fletcher; Hideyuki Okano; D J Gilbert; Y Yang; C Yang; N G Copeland; N A Jenkins; Robert B Darnell
Mouse chromosomal locations of nine genes encoding homologs of human paraneoplastic neurologic disorder antigens.
Genomics 1997;45(2):313-9.
1997: H Fei; HJ Okano; C Li; G H Lee; C Zhao; Robert B Darnell; Jeffrey M Friedman
Anatomic localization of alternatively spliced leptin receptors (Ob-R) in mouse brain and other tissues.
Proceedings of the National Academy of Sciences of the United States of America 1997;94(13):7001-5.
1997: Ronald J Buckanovich; Robert B Darnell
The neuronal RNA binding protein Nova-1 recognizes specific RNA targets in vitro and in vivo.
Molecular and cellular biology 1997;17(6):3194-201.
1997: H J Okano; Robert B Darnell
A hierarchy of Hu RNA binding proteins in developing and adult neurons.
The Journal of neuroscience : the official journal of the Society for Neuroscience 1997;17(9):3024-37.
1997: J P Corradi; C Yang; Jennifer C Darnell; J Dalmau; Robert B Darnell
A post-transcriptional regulatory mechanism restricts expression of the paraneoplastic cerebellar degeneration antigen cdr2 to immune privileged tissues.
The Journal of neuroscience : the official journal of the Society for Neuroscience 1997;17(4):1406-15.
1996: Robert B Darnell
Onconeural antigens and the paraneoplastic neurologic disorders: at the intersection of cancer, immunity, and the brain.
Proceedings of the National Academy of Sciences of the United States of America 1996;93(10):4529-36.
1996: F Simpson; Nicholas A Bright; M A West; L S Newman; Robert B Darnell; Margaret S Robinson
A novel adaptor-related protein complex.
The Journal of cell biology 1996;133(4):749-60.
1996: Ronald J Buckanovich; YY Yang; Robert B Darnell
The onconeural antigen Nova-1 is a neuron-specific RNA-binding protein, the activity of which is inhibited by paraneoplastic antibodies.
The Journal of neuroscience : the official journal of the Society for Neuroscience 1996;16(3):1114-22.
1995: L S Newman; M O McKeever; Hideyuki Okano; Robert B Darnell
Beta-NAP, a cerebellar degeneration antigen, is a neuron-specific vesicle coat protein.
Cell 1995;82(5):773-83.
1993: Ronald J Buckanovich; Jerome B Posner; Robert B Darnell
Nova, the paraneoplastic Ri antigen, is homologous to an RNA-binding protein and is specifically expressed in the developing motor system.
Neuron 1993;11(4):657-72.
1993: Robert B Darnell
The polymerase chain reaction: application to nervous system disease.
Annals of neurology 1993;34(4):513-23.