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Timothy Darrow

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James Grichnik; James A Burch; Ryan D Schulteis; Siqing Shan; Jie Liu; Timothy L Darrow; Carol E Vervaert; Hilliard F Seigler
Melanoma, a tumor based on a mutant stem cell?
Rahima Zennadi; Zeinab Abdel-Wahab; Hilliard F Seigler; Timothy L Darrow
Generation of melanoma-specific, cytotoxic CD4(+) T helper 2 cells: requirement of both HLA-DR15 and Fas antigens on melanomas for their lysis by Th2 cells.
S Yang; DJ Kittlesen; Craig L Slingluff; Carol E Vervaert; Hilliard F Seigler; Timothy L Darrow
Dendritic cells infected with a vaccinia vector carrying the human gp100 gene simultaneously present multiple specificities and elicit high-affinity T cells reactive to multiple epitopes and restricted by HLA-A2 and -A3.

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All Publications

2006: James Grichnik; James A Burch; Ryan D Schulteis; Siqing Shan; Jie Liu; Timothy L Darrow; Carol E Vervaert; Hilliard F Seigler
Melanoma, a tumor based on a mutant stem cell?
The Journal of investigative dermatology 2006;126(1):142-53.
2001: Rahima Zennadi; Zeinab Abdel-Wahab; Hilliard F Seigler; Timothy L Darrow
Generation of melanoma-specific, cytotoxic CD4(+) T helper 2 cells: requirement of both HLA-DR15 and Fas antigens on melanomas for their lysis by Th2 cells.
Cellular immunology 2001;210(2):96-105.
2000: S Yang; DJ Kittlesen; Craig L Slingluff; Carol E Vervaert; Hilliard F Seigler; Timothy L Darrow
Dendritic cells infected with a vaccinia vector carrying the human gp100 gene simultaneously present multiple specificities and elicit high-affinity T cells reactive to multiple epitopes and restricted by HLA-A2 and -A3.
Journal of immunology (Baltimore, Md. : 1950) 2000;164(8):4204-11.
2000: Craig L Slingluff; Teresa A Colella; Lee Thompson; D D Graham; JC Skipper; J Caldwell; Laurence H Brinckerhoff; DJ Kittlesen; Donna H Deacon; C Oei; Nancy L Harthun; EL Huczko; Donald F Hunt; Timothy L Darrow; Victor H Engelhard
Melanomas with concordant loss of multiple melanocytic differentiation proteins: immune escape that may be overcome by targeting unique or undefined antigens.
Cancer immunology, immunotherapy : CII 2000;48(12):661-72.
1999: S Yang; Carol E Vervaert; Jarrett Burch; James Grichnik; Hilliard F Seigler; Timothy L Darrow
Murine dendritic cells transfected with human GP100 elicit both antigen-specific CD8(+) and CD4(+) T-cell responses and are more effective than DNA vaccines at generating anti-tumor immunity.
International journal of cancer. Journal international du cancer 1999;83(4):532-40.
1999: S Yang; Carol E Vervaert; Hilliard F Seigler; Timothy L Darrow
Tumor cells cotransduced with B7.1 and gamma-IFN induce effective rejection of established parental tumor.
Gene therapy 1999;6(2):253-62.
1997: S Yang; Timothy L Darrow; Carol E Vervaert; Hilliard F Seigler
Immunotherapeutic potential of tumor antigen-pulsed and unpulsed dendritic cells generated from murine bone marrow.
Cellular immunology 1997;179(1):84-95.
1997: S Yang; Timothy L Darrow; Hilliard F Seigler
Generation of primary tumor-specific cytotoxic T lymphocytes from autologous and human lymphocyte antigen class I-matched allogeneic peripheral blood lymphocytes by B7 gene-modified melanoma cells.
Cancer research 1997;57(8):1561-8.
1996: K R Stidham; W M Ricci; Carol E Vervaert; Zeinab Abdel-Wahab; Hilliard F Seigler; Timothy L Darrow
Modulation of specific active immunization against murine melanoma using recombinant cytokines.
Surgical oncology 1996;5(5-6):221-9.
1996: Timothy L Darrow; Zeinab Abdel-Wahab; Mary Ann Quinn-Allen; Hilliard F Seigler
Recognition and lysis of human melanoma by a CD3+, CD4+, CD8- T-cell clone restricted by HLA-A2.
Cellular immunology 1996;172(1):52-9.
1996: Zeinab Abdel-Wahab; M M Dar; D Hester; Carol E Vervaert; R Gangavalli; J Barber; Timothy L Darrow; Hilliard F Seigler
Effect of irradiation on cytokine production, MHC antigen expression, and vaccine potential of interleukin-2 and interferon-gamma gene-modified melanoma cells.
Cellular immunology 1996;171(2):246-54.
1996: H Kubo; J Abe; Fumiya Obata; H Nakajima; M Tsunoda; A Ogawa; S Nakayama; Yoshifumi Beck; T Kohsaka; Timothy L Darrow; Zeinab Abdel-Wahab; T Saida; M Takiguchi
Dual recognition of a human cytotoxic T-cell clone for melanoma antigens.
Cancer research 1996;56(10):2368-74.
1996: M M Dar; Zeinab Abdel-Wahab; Carol E Vervaert; Timothy L Darrow; J Barber; Hilliard F Seigler
Immunological memory induced by genetically transduced tumor cells.
Annals of surgical oncology 1996;3(3):247-54.
1994: Zeinab Abdel-Wahab; W P Li; S Osanto; Timothy L Darrow; J Hessling; Carol E Vervaert; M Burrascano; J Barber; Hilliard F Seigler
Transduction of human melanoma cells with interleukin-2 gene reduces tumorigenicity and enhances host antitumor immunity: a nude mouse model.
Cellular immunology 1994;159(1):26-39.
1994: Zeinab Abdel-Wahab; S Osanto; Timothy L Darrow; J R Barber; Carol E Vervaert; R Gangavalli; T J McCallister; Hilliard F Seigler
Transduction of human melanoma cells with the gamma interferon gene enhances cellular immunity.
Cancer gene therapy 1994;1(3):171-9.
1994: Hilliard F Seigler; Timothy L Darrow; Zeinab Abdel-Wahab; R Gangavalli; J Barber
A phase I trial of human gamma interferon transduced autologous tumor cells in patients with disseminated malignant melanoma.
Human gene therapy 1994;5(6):761-77.
1994: B Howard; M Burrascano; T McCallister; K Chong; R Gangavalli; L Severinsson; Douglas J Jolly; Timothy L Darrow; Carol E Vervaert; Zeinab Abdel-Wahab
Retrovirus-mediated gene transfer of the human gamma-IFN gene: a therapy for cancer.
Annals of the New York Academy of Sciences 1994;716():167-87.
1994: Andrea L Cox; JC Skipper; Y Chen; R A Henderson; Timothy L Darrow; Jeffrey Shabanowitz; Victor H Engelhard; Donald F Hunt; Craig L Slingluff
Identification of a peptide recognized by five melanoma-specific human cytotoxic T cell lines.
Science (New York, N.Y.) 1994;264(5159):716-9.
1993: Zeinab Abdel-Wahab; W P Li; Timothy L Darrow; E D Nudelman; A Towell; Hilliard F Seigler
Cell surface reactive human monoclonal antibody directed to human melanoma-associated gangliosides.
Melanoma research 1993;3(6):415-23.
1992: Timothy L Darrow; Z Wahab; Mary Ann Quinn-Allen; Hilliard F Seigler
Human melanoma-mediated inhibition of autologous CD4+ helper tumor-infiltrating lymphocyte growth in vitro.
Cancer 1992;69(7):1843-9.
1992: Zeinab Abdel-Wahab; Timothy L Darrow; Carol E Vervaert; A A Giannopoulou; W Li; Hilliard F Seigler
Inhibition of the growth of human melanoma metastases in nude mice by melanoma-specific murine monoclonal antibody.
Surgical oncology 1992;1(2):115-25.
1992: Zeinab Abdel-Wahab; W E Gillanders; Timothy L Darrow; Hilliard F Seigler
Generation of human IgG, IgA, and IgM anti-melanoma monoclonal antibodies utilizing lymphocytes of an actively immunized melanoma patient.
Human antibodies and hybridomas 1992;3(1):32-9.
1991: Zeinab Abdel-Wahab; Timothy L Darrow; Carol E Vervaert; N J Crowley; Hilliard F Seigler
Cell binding and tumor inhibiting functions of a new antihuman melanoma murine monoclonal antibody.
Molecular biotherapy 1991;3(3):163-9.
1991: N J Crowley; Timothy L Darrow; Mary Ann Quinn-Allen; Hilliard F Seigler
MHC-restricted recognition of autologous melanoma by tumor-specific cytotoxic T cells. Evidence for restriction by a dominant HLA-A allele.
Journal of immunology (Baltimore, Md. : 1950) 1991;146(5):1692-9.
1990: Craig L Slingluff; Hilliard F Seigler; Timothy L Darrow; C H Evans
Implications of leukoregulin to autologous tumor-specific human T-cell populations.
Journal of biological response modifiers 1990;9(4):387-94.
1990: N J Crowley; Craig L Slingluff; Carol E Vervaert; Timothy L Darrow; Hilliard F Seigler
Inhibition of the growth of human melanoma xenografts in nude mice by human tumor-specific cytotoxic T-cells.
Journal of surgical oncology 1990;43(2):67-72.
1990: N J Crowley; Craig L Slingluff; Timothy L Darrow; Hilliard F Seigler
Generation of human autologous melanoma-specific cytotoxic T-cells using HLA-A2-matched allogeneic melanomas.
Cancer research 1990;50(3):492-8.
1990: Timothy L Darrow; Mary Ann Quinn-Allen; N J Crowley; Hilliard F Seigler
Modulation of in vitro autologous melanoma-specific cytotoxic T-cell responses by phorbol dibutyrate and ionomycin.
Cellular immunology 1990;125(2):508-17.
1989: N J Crowley; Timothy L Darrow; H F Seigler
Generation of autologous tumor-specific cytotoxic T-cells using HLA-A region matched allogeneic melanoma.
Current surgery 1989;46(5):393-6.
1989: Craig L Slingluff; Timothy L Darrow; Hilliard F Seigler
Melanoma-specific cytotoxic T cells generated from peripheral blood lymphocytes. Implications of a renewable source of precursors for adoptive cellular immunotherapy.
Annals of surgery 1989;210(2):194-202.
1989: Timothy L Darrow; Craig L Slingluff; Hilliard F Seigler
The role of HLA class I antigens in recognition of melanoma cells by tumor-specific cytotoxic T lymphocytes. Evidence for shared tumor antigens.
Journal of immunology (Baltimore, Md. : 1950) 1989;142(9):3329-35.
1988: Craig L Slingluff; Timothy L Darrow; Carol E Vervaert; Mary Ann Quinn-Allen; Hilliard F Seigler
Human cytotoxic T cells specific for autologous melanoma cells: successful generation from lymph node cells in seven consecutive cases.
Journal of the National Cancer Institute 1988;80(13):1016-26.
1988: Timothy L Darrow; Craig L Slingluff; Hilliard F Seigler
Autologous lymph node cell-derived tumor-specific cytotoxic T-cells for use in adoptive immunotherapy of human melanoma.
Cancer 1988;62(1):84-91.
1987: Craig L Slingluff; Timothy L Darrow; Hilliard F Seigler
Human T cells specifically activated against autologous malignant melanoma.
Archives of surgery (Chicago, Ill. : 1960) 1987;122(12):1407-11.