Seth Darst

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Lamour Valerie; Westblade Lars F; Campbell Elizabeth A; Darst Seth A
Crystal structure of the in vivo-assembled Bacillus subtilis Spx/RNA polymerase alpha subunit C-terminal domain complex.
Feklistov Andrey; Darst Seth A
Promoter recognition by bacterial alternative sigma factors: the price of high selectivity?
Bick Matthew J; Lamour Valerie; Rajashankar Kanagalaghatta R; Gordiyenko Yuliya; Robinson Carol V; Darst Seth A
How to switch off a histidine kinase: crystal structure of Geobacillus stearothermophilus KinB with the inhibitor Sda.

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All Publications

2009: Lamour Valerie; Westblade Lars F; Campbell Elizabeth A; Darst Seth A
Crystal structure of the in vivo-assembled Bacillus subtilis Spx/RNA polymerase alpha subunit C-terminal domain complex.
Journal of structural biology 2009;168(2):352-6.
2009: Feklistov Andrey; Darst Seth A
Promoter recognition by bacterial alternative sigma factors: the price of high selectivity?
Genes & development 2009;23(20):2371-5.
2009: Bick Matthew J; Lamour Valerie; Rajashankar Kanagalaghatta R; Gordiyenko Yuliya; Robinson Carol V; Darst Seth A
How to switch off a histidine kinase: crystal structure of Geobacillus stearothermophilus KinB with the inhibitor Sda.
Journal of molecular biology 2009;386(1):163-77.
2008: Lamour Valerie; Rutherford Steven T; Kuznedelov Konstantin; Ramagopal Udupi A; Gourse Richard L; Severinov Konstantin; Darst Seth A
Crystal structure of Escherichia coli Rnk, a new RNA polymerase-interacting protein.
Journal of molecular biology 2008;383(2):367-79.
2008: Schwartz Edmund C; Shekhtman Alexander; Dutta Kaushik; Pratt Matthew R; Cowburn David; Darst Seth; Muir Tom W
A full-length group 1 bacterial sigma factor adopts a compact structure incompatible with DNA binding.
Chemistry & biology 2008;15(10):1091-103.
2008: Feklistov Andrey; Mekler Vladimir; Jiang Qiaorong; Westblade Lars F; Irschik Herbert; Jansen Rolf; Mustaev Arkady; Darst Seth A; Ebright Richard H
Rifamycins do not function by allosteric modulation of binding of Mg2+ to the RNA polymerase active center.
Proceedings of the National Academy of Sciences of the United States of America 2008;105(39):14820-5.
2008: Campbell Elizabeth A; Westblade Lars F; Darst Seth A
Regulation of bacterial RNA polymerase sigma factor activity: a structural perspective.
Current opinion in microbiology 2008;11(2):121-7.
2008: Westblade Lars F; Minakhin Leonid; Kuznedelov Konstantin; Tackett Alan J; Chang Emmanuel J; Mooney Rachel A; Vvedenskaya Irina; Wang Qing Jun; Fenyö David; Rout Michael P; Landick Robert; Chait Brian T; Severinov Konstantin; Darst Seth A
Rapid isolation and identification of bacteriophage T4-encoded modifications of Escherichia coli RNA polymerase: a generic method to study bacteriophage/host interactions.
Journal of proteome research 2008;7(3):1244-50.
2007: Campbell Elizabeth A; Greenwell Roger; Anthony Jennifer R; Wang Sheng; Lim Lionel; Das Kalyan; Sofia Heidi J; Donohue Timothy J; Darst Seth A
A conserved structural module regulates transcriptional responses to diverse stress signals in bacteria.
Molecular cell 2007;27(5):793-805.
2007: Patikoglou Georgia A; Westblade Lars F; Campbell Elizabeth A; Lamour Valérie; Lane William J; Darst Seth A
Crystal structure of the Escherichia coli regulator of sigma70, Rsd, in complex with sigma70 domain 4.
Journal of molecular biology 2007;372(3):649-59.
2007: Deaconescu Alexandra M; Savery Nigel; Darst Seth A
The bacterial transcription repair coupling factor.
Current opinion in structural biology 2007;17(1):96-102.
2006: Sorenson Margareta K; Darst Seth A
Disulfide cross-linking indicates that FlgM-bound and free sigma28 adopt similar conformations.
Proceedings of the National Academy of Sciences of the United States of America 2006;103(45):16722-7.
2006: Lane William J; Darst Seth A
The structural basis for promoter -35 element recognition by the group IV sigma factors.
PLoS biology 2006;4(9):e269.
2006: Kuznedelov Konstantin; Lamour Valerie; Patikoglou Georgia; Chlenov Mark; Darst Seth A; Severinov Konstantin
Recombinant Thermus aquaticus RNA polymerase for structural studies.
Journal of molecular biology 2006;359(1):110-21.
2006: Deaconescu Alexandra M; Chambers Anna L; Smith Abigail J; Nickels Bryce E; Hochschild Ann; Savery Nigel J; Darst Seth A
Structural basis for bacterial transcription-coupled DNA repair.
Cell 2006;124(3):507-20.
2006: Lamour Valerie; Hogan Brian P; Erie Dorothy A; Darst Seth A
Crystal structure of Thermus aquaticus Gfh1, a Gre-factor paralog that inhibits rather than stimulates transcript cleavage.
Journal of molecular biology 2006;356(1):179-88.
2005: Deaconescu Alexandra M; Darst Seth A
Crystallization and preliminary structure determination of Escherichia coli Mfd, the transcription-repair coupling factor.
Acta crystallographica. Section F, Structural biology and crystallization communications 2005;61(Pt 12):1062-4.
2005: Mooney Rachel Anne; Darst Seth A; Landick Robert
Sigma and RNA polymerase: an on-again, off-again relationship?
Molecular cell 2005;20(3):335-45.
2005: Chlenov Mark; Masuda Shoko; Murakami Katsuhiko S; Nikiforov Vadim; Darst Seth A; Mustaev Arkady
Structure and function of lineage-specific sequence insertions in the bacterial RNA polymerase beta' subunit.
Journal of molecular biology 2005;353(1):138-54.
2005: Jain Deepti; Kim Youngchang; Maxwell Karen L; Beasley Steven; Zhang Rongguang; Gussin Gary N; Edwards Aled M; Darst Seth A
Crystal structure of bacteriophage lambda cII and its DNA complex.
Molecular cell 2005;19(2):259-69.
2005: Gregory Brian D; Nickels Bryce E; Darst Seth A; Hochschild Ann
An altered-specificity DNA-binding mutant of Escherichia coli sigma70 facilitates the analysis of sigma70 function in vivo.
Molecular microbiology 2005;56(5):1208-19.
2005: Campbell Elizabeth A; Pavlova Olga; Zenkin Nikolay; Leon Fred; Irschik Herbert; Jansen Rolf; Severinov Konstantin; Darst Seth A
Structural, functional, and genetic analysis of sorangicin inhibition of bacterial RNA polymerase.
The EMBO journal 2005;24(4):674-82.
2004: Masuda Shoko; Murakami Katsuhiko S; Wang Sheng; Anders Olson C; Donigian Jill; Leon Fred; Darst Seth A; Campbell Elizabeth A
Crystal structures of the ADP and ATP bound forms of the Bacillus anti-sigma factor SpoIIAB in complex with the anti-anti-sigma SpoIIAA.
Journal of molecular biology 2004;340(5):941-56.
2004: Darst Seth A
New inhibitors targeting bacterial RNA polymerase.
Trends in biochemical sciences 2004;29(4):159-60.
2004: Sorenson Margareta K; Ray Soumya S; Darst Seth A
Crystal structure of the flagellar sigma/anti-sigma complex sigma(28)/FlgM reveals an intact sigma factor in an inactive conformation.
Molecular cell 2004;14(1):127-38.
2004: Lawson Catherine L; Swigon David; Murakami Katsuhiko S; Darst Seth A; Berman Helen M; Ebright Richard H
Catabolite activator protein: DNA binding and transcription activation.
Current opinion in structural biology 2004;14(1):10-20.
2004: Jain Deepti; Nickels Bryce E; Sun Li; Hochschild Ann; Darst Seth A
Structure of a ternary transcription activation complex.
Molecular cell 2004;13(1):45-53.
2003: Wilson Kelly-Anne; Kalkum Markus; Ottesen Jennifer; Yuzenkova Julia; Chait Brian T; Landick Robert; Muir Tom; Severinov Konstantin; Darst Seth A
Structure of microcin J25, a peptide inhibitor of bacterial RNA polymerase, is a lassoed tail.
Journal of the American Chemical Society 2003;125(41):12475-83.
2003: Opalka Natacha; Chlenov Mark; Chacon Pablo; Rice William J; Wriggers Willy; Darst Seth A
Structure and function of the transcription elongation factor GreB bound to bacterial RNA polymerase.
Cell 2003;114(3):335-45.
2003: Dove Simon L; Darst Seth A; Hochschild Ann
Region 4 of sigma as a target for transcription regulation.
Molecular microbiology 2003;48(4):863-74.
2003: Campbell Elizabeth A; Tupy Jonathan L; Gruber Tanja M; Wang Sheng; Sharp Meghan M; Gross Carol A; Darst Seth A
Crystal structure of Escherichia coli sigmaE with the cytoplasmic domain of its anti-sigma RseA.
Molecular cell 2003;11(4):1067-78.
2003: Murakami Katsuhiko S; Darst Seth A
Bacterial RNA polymerases: the wholo story.
Current opinion in structural biology 2003;13(1):31-9.
2003: Opalka Natacha; Beckmann Roland; Boisset Nicolas; Simon Martha N; Russel Marjorie; Darst Seth A
Structure of the filamentous phage pIV multimer by cryo-electron microscopy.
Journal of molecular biology 2003;325(3):461-70.
2003: Murakami Katsuhiko S; Masuda Shoko; Darst Seth A
Crystallographic analysis of Thermus aquaticus RNA polymerase holoenzyme and a holoenzyme/promoter DNA complex.
Methods in enzymology 2003;370():42-53.
2002: Nickels Bryce E; Dove Simon L; Murakami Katsuhiko S; Darst Seth A; Hochschild Ann
Protein-protein and protein-DNA interactions of sigma70 region 4 involved in transcription activation by lambdacI.
Journal of molecular biology 2002;324(1):17-34.
2002: Camarero Julio A; Shekhtman Alexander; Campbell Elizabeth A; Chlenov Mark; Gruber Tanja M; Bryant Donald A; Darst Seth A; Cowburn David; Muir Tom W
Autoregulation of a bacterial sigma factor explored by using segmental isotopic labeling and NMR.
Proceedings of the National Academy of Sciences of the United States of America 2002;99(13):8536-41.
2002: Murakami Katsuhiko S; Masuda Shoko; Campbell Elizabeth A; Muzzin Oriana; Darst Seth A
Structural basis of transcription initiation: an RNA polymerase holoenzyme-DNA complex.
Science (New York, N.Y.) 2002;296(5571):1285-90.
2002: Murakami Katsuhiko S; Masuda Shoko; Darst Seth A
Structural basis of transcription initiation: RNA polymerase holoenzyme at 4 A resolution.
Science (New York, N.Y.) 2002;296(5571):1280-4.
2002: Darst Seth A; Opalka Natacha; Chacon Pablo; Polyakov Andrey; Richter Catherine; Zhang Gongyi; Wriggers Willy
Conformational flexibility of bacterial RNA polymerase.
Proceedings of the National Academy of Sciences of the United States of America 2002;99(7):4296-301.
2002: Campbell Elizabeth A; Masuda Shoko; Sun Jing L; Muzzin Oriana; Olson C Anders; Wang Sheng; Darst Seth A
Crystal structure of the Bacillus stearothermophilus anti-sigma factor SpoIIAB with the sporulation sigma factor sigmaF.
Cell 2002;108(6):795-807.
2002: Campbell Elizabeth A; Muzzin Oriana; Chlenov Mark; Sun Jing L; Olson C Anders; Weinman Oren; Trester-Zedlitz Michelle L; Darst Seth A
Structure of the bacterial RNA polymerase promoter specificity sigma subunit.
Molecular cell 2002;9(3):527-39.
2001: Darst S A
Bacterial RNA polymerase.
Current opinion in structural biology 2001;11(2):155-62.
2001: Naryshkina T; Mustaev A; Darst S A; Severinov K
The beta ' subunit of Escherichia coli RNA polymerase is not required for interaction with initiating nucleotide but is necessary for interaction with rifampicin.
The Journal of biological chemistry 2001;276(16):13308-13.
2001: Campbell E A; Korzheva N; Mustaev A; Murakami K; Nair S; Goldfarb A; Darst S A
Structural mechanism for rifampicin inhibition of bacterial rna polymerase.
Cell 2001;104(6):901-12.
2001: Minakhin L; Bhagat S; Brunning A; Campbell E A; Darst S A; Ebright R H; Severinov K
Bacterial RNA polymerase subunit omega and eukaryotic RNA polymerase subunit RPB6 are sequence, structural, and functional homologs and promote RNA polymerase assembly.
Proceedings of the National Academy of Sciences of the United States of America 2001;98(3):892-7.
2000: Korzheva N; Mustaev A; Kozlov M; Malhotra A; Nikiforov V; Goldfarb A; Darst S A
A structural model of transcription elongation.
Science (New York, N.Y.) 2000;289(5479):619-25.
2000: Campbell E A; Darst S A
The anti-sigma factor SpoIIAB forms a 2:1 complex with sigma(F), contacting multiple conserved regions of the sigma factor.
Journal of molecular biology 2000;300(1):17-28.
2000: Kulish D; Lee J; Lomakin I; Nowicka B; Das A; Darst S; Normet K; Borukhov S
The functional role of basic patch, a structural element of Escherichia coli transcript cleavage factors GreA and GreB.
The Journal of biological chemistry 2000;275(17):12789-98.
2000: Opalka N; Mooney R A; Richter C; Severinov K; Landick R; Darst S A
Direct localization of a beta-subunit domain on the three-dimensional structure of Escherichia coli RNA polymerase.
Proceedings of the National Academy of Sciences of the United States of America 2000;97(2):617-22.
1999: Zhang G; Campbell E A; Minakhin L; Richter C; Severinov K; Darst S A
Crystal structure of Thermus aquaticus core RNA polymerase at 3.3 A resolution.
Cell 1999;98(6):811-24.
1999: Loizos N; Darst S A
Mapping interactions of Escherichia coli GreB with RNA polymerase and ternary elongation complexes.
The Journal of biological chemistry 1999;274(33):23378-86.
1998: Darst S A; Polyakov A; Richter C; Zhang G
Insights into Escherichia coli RNA polymerase structure from a combination of x-ray and electron crystallography.
Journal of structural biology 1998;124(2-3):115-22.
1998: Polyakov A; Richter C; Malhotra A; Koulich D; Borukhov S; Darst S A
Visualization of the binding site for the transcript cleavage factor GreB on Escherichia coli RNA polymerase.
Journal of molecular biology 1998;281(3):465-73.
1998: Zhang G; Darst S A
Structure of the Escherichia coli RNA polymerase alpha subunit amino-terminal domain.
Science (New York, N.Y.) 1998;281(5374):262-6.
1998: Darst S A
A new twist on protein crystallization.
Proceedings of the National Academy of Sciences of the United States of America 1998;95(14):7848-9.
1998: Loizos N; Darst S A
Mapping protein-ligand interactions by footprinting, a radical idea.
Structure (London, England : 1993) 1998;6(6):691-5.
1998: Muzzin O; Campbell E A; Xia L; Severinova E; Darst S A; Severinov K
Disruption of Escherichia coli hepA, an RNA polymerase-associated protein, causes UV sensitivity.
The Journal of biological chemistry 1998;273(24):15157-61.
1998: Severinova E; Severinov K; Darst S A
Inhibition of Escherichia coli RNA polymerase by bacteriophage T4 AsiA.
Journal of molecular biology 1998;279(1):9-18.
1998: Darst S A; Polyakov A; Richter C; Zhang G
Structural studies of Escherichia coli RNA polymerase.
Cold Spring Harbor symposia on quantitative biology 1998;63():269-76.
1997: Severinov K; Darst S A
A mutant RNA polymerase that forms unusual open promoter complexes.
Proceedings of the National Academy of Sciences of the United States of America 1997;94(25):13481-6.
1997: Severinov K; Mooney R; Darst S A; Landick R
Tethering of the large subunits of Escherichia coli RNA polymerase.
The Journal of biological chemistry 1997;272(39):24137-40.
1997: Wang Y; Severinov K; Loizos N; Fenyö D; Heyduk E; Heyduk T; Chait B T; Darst S A
Determinants for Escherichia coli RNA polymerase assembly within the beta subunit.
Journal of molecular biology 1997;270(5):648-62.
1997: Koulich D; Orlova M; Malhotra A; Sali A; Darst S A; Borukhov S
Domain organization of Escherichia coli transcript cleavage factors GreA and GreB.
The Journal of biological chemistry 1997;272(11):7201-10.
1996: Severinova E; Severinov K; Fenyö D; Marr M; Brody E N; Roberts J W; Chait B T; Darst S A
Domain organization of the Escherichia coli RNA polymerase sigma 70 subunit.
Journal of molecular biology 1996;263(5):637-47.
1996: Severinov K; Mustaev A; Kukarin A; Muzzin O; Bass I; Darst S A; Goldfarb A
Structural modules of the large subunits of RNA polymerase. Introducing archaebacterial and chloroplast split sites in the beta and beta' subunits of Escherichia coli RNA polymerase.
The Journal of biological chemistry 1996;271(44):27969-74.
1996: Malhotra A; Severinova E; Darst S A
Crystal structure of a sigma 70 subunit fragment from E. coli RNA polymerase.
Cell 1996;87(1):127-36.
1995: Severinov K; Mustaev A; Severinova E; Kozlov M; Darst S A; Goldfarb A
The beta subunit Rif-cluster I is only angstroms away from the active center of Escherichia coli RNA polymerase.
The Journal of biological chemistry 1995;270(49):29428-32.
1995: Polyakov A; Severinova E; Darst S A
Three-dimensional structure of E. coli core RNA polymerase: promoter binding and elongation conformations of the enzyme.
Cell 1995;83(3):365-73.
1995: Darst S A; Edwards A M
Epitaxial growth of protein crystals from two-dimensional crystals on lipid layers.
Current opinion in structural biology 1995;5(5):640-4.
1995: Severinov K; Markov D; Severinova E; Nikiforov V; Landick R; Darst S A; Goldfarb A
Streptolydigin-resistant mutants in an evolutionarily conserved region of the beta' subunit of Escherichia coli RNA polymerase.
The Journal of biological chemistry 1995;270(41):23926-9.
1995: Severinov K; Mustaev A; Severinova E; Bass I; Kashlev M; Landick R; Nikiforov V; Goldfarb A; Darst S A
Assembly of functional Escherichia coli RNA polymerase containing beta subunit fragments.
Proceedings of the National Academy of Sciences of the United States of America 1995;92(10):4591-5.
1995: Stebbins C E; Borukhov S; Orlova M; Polyakov A; Goldfarb A; Darst S A
Crystal structure of the GreA transcript cleavage factor from Escherichia coli.
Nature 1995;373(6515):636-40.
1994: Darst S A; Stebbins C E; Borukhov S; Orlova M; Feng G; Landick R; Goldfarb A
Crystallization of GreA, a transcript cleavage factor from Escherichia coli.
Journal of molecular biology 1994;242(4):582-5.
1994: Severinov K; Fenyö D; Severinova E; Mustaev A; Chait B T; Goldfarb A; Darst S A
The sigma subunit conserved region 3 is part of "5'-face" of active center of Escherichia coli RNA polymerase.
The Journal of biological chemistry 1994;269(33):20826-8.

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Seth Darst

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