Darlene Dartt

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Turpie Bruce; Yoshimura Takeru; Gulati Abha; Rios Jose David; Dartt Darlene A; Masli Sharmila
Sjögren's syndrome-like ocular surface disease in thrombospondin-1 deficient mice.
Dartt Darlene A
Neural regulation of lacrimal gland secretory processes: relevance in dry eye diseases.
Shatos Marie A; Hodges Robin R; Bair Jeffrey A; Lashkari Kameran; Dartt Darlene A
Stimulatory role of PKCalpha in extracellular regulated kinase 1/2 pathway in conjunctival goblet cell proliferation.

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2009: Turpie Bruce; Yoshimura Takeru; Gulati Abha; Rios Jose David; Dartt Darlene A; Masli Sharmila
Sjögren's syndrome-like ocular surface disease in thrombospondin-1 deficient mice.
The American journal of pathology 2009;175(3):1136-47.
2009: Dartt Darlene A
Neural regulation of lacrimal gland secretory processes: relevance in dry eye diseases.
Progress in retinal and eye research 2009;28(3):155-77.
2009: Shatos Marie A; Hodges Robin R; Bair Jeffrey A; Lashkari Kameran; Dartt Darlene A
Stimulatory role of PKCalpha in extracellular regulated kinase 1/2 pathway in conjunctival goblet cell proliferation.
Investigative ophthalmology & visual science 2009;50(4):1619-25.
2009: Shatos Marie A; Hodges Robin R; Oshi Yoshia; Bair Jeffrey A; Zoukhri Driss; Kublin Claire; Lashkari Kameran; Dartt Darlene A
Role of cPKCalpha and nPKCepsilon in EGF-stimulated goblet cell proliferation.
Investigative ophthalmology & visual science 2009;50(2):614-20.
2008: Shatos Marie A; Gu Jian; Hodges Robin R; Lashkari Kameran; Dartt Darlene A
ERK/p44p42 mitogen-activated protein kinase mediates EGF-stimulated proliferation of conjunctival goblet cells in culture.
Investigative ophthalmology & visual science 2008;49(8):3351-9.
2008: Ríos J David; Shatos Marie A; Urashima Hiroki; Dartt Darlene A
Effect of OPC-12759 on EGF receptor activation, p44/p42 MAPK activity, and secretion in conjunctival goblet cells.
Experimental eye research 2008;86(4):629-36.
2008: Gu Jian; Chen Lili; Shatos Marie A; Rios J David; Gulati Abha; Hodges Robin R; Dartt Darlene A
Presence of EGF growth factor ligands and their effects on cultured rat conjunctival goblet cell proliferation.
Experimental eye research 2008;86(2):322-34.
2008: Konomi Keiko; Chen Li-Li; Tarko Rachel S; Scally Amy; Schaumberg Debra A; Azar Dimitri; Dartt Darlene A
Preoperative characteristics and a potential mechanism of chronic dry eye after LASIK.
Investigative ophthalmology & visual science 2008;49(1):168-74.
2007: Graham Joanna E; Moore Jonathan E; Jiru Xu; Moore John E; Goodall Edward A; Dooley James S G; Hayes Velma E A; Dartt Darlene A; Downes C Stephen; Moore Tara C B
Ocular pathogen or commensal: a PCR-based study of surface bacterial flora in normal and dry eyes.
Investigative ophthalmology & visual science 2007;48(12):5616-23.
2007: Hodges Robin R; Horikawa Yoshitaka; Rios Jose D; Shatos Marie A; Dartt Darlene A
Effect of protein kinase C and Ca(2+) on p42/p44 MAPK, Pyk2, and Src activation in rat conjunctival goblet cells.
Experimental eye research 2007;85(6):836-44.
2007: Funaki Chika; Hodges Robin R; Dartt Darlene A
Role of cAMP inhibition of p44/p42 mitogen-activated protein kinase in potentiation of protein secretion in rat lacrimal gland.
American journal of physiology. Cell physiology 2007;293(5):C1551-60.
2007: Collins James F; Dartt Darlene A; Dana Reza
Mist delivery of eye medication to the anterior segment.
American journal of ophthalmology 2007;144(1):137-9.
2007: Ríos J David; Ghinelli Emiliano; Gu Jian; Hodges Robin R; Dartt Darlene A
Role of neurotrophins and neurotrophin receptors in rat conjunctival goblet cell secretion and proliferation.
Investigative ophthalmology & visual science 2007;48(4):1543-51.
2007: Diebold Yolanda; Chen Li-Li; Tepavcevic Vanja; Ferdman Dina; Hodges Robin R; Dartt Darlene A
Lymphocytic infiltration and goblet cell marker alteration in the conjunctiva of the MRL/MpJ-Fas(lpr) mouse model of Sjögren's syndrome.
Experimental eye research 2007;84(3):500-12.
2006: Chen LiLi; Hodges Robin R; Funaki Chika; Zoukhri Driss; Gaivin Robert J; Perez Dianne M; Dartt Darlene A
Effects of alpha1D-adrenergic receptors on shedding of biologically active EGF in freshly isolated lacrimal gland epithelial cells.
American journal of physiology. Cell physiology 2006;291(5):C946-56.
2006: Hodges Robin R; Rios Jose D; Vrouvlianis Joanna; Ota Isao; Zoukhri Driss; Dartt Darlene A
Roles of protein kinase C, Ca2+, Pyk2, and c-Src in agonist activation of rat lacrimal gland p42/p44 MAPK.
Investigative ophthalmology & visual science 2006;47(8):3352-9.
2006: Ríos José D; Shatos Marie; Urashima Hiroki; Tran Hao; Dartt Darlene A
OPC-12759 increases proliferation of cultured rat conjunctival goblet cells.
Cornea 2006;25(5):573-81.
2005: Jerdeva Galina V; Yarber Francie A; Trousdale Melvin D; Rhodes Christopher J; Okamoto Curtis T; Dartt Darlene A; Hamm-Alvarez Sarah F
Dominant-negative PKC-epsilon impairs apical actin remodeling in parallel with inhibition of carbachol-stimulated secretion in rabbit lacrimal acini.
American journal of physiology. Cell physiology 2005;289(4):C1052-68.
2005: Hodges Robin R; Shatos Marie A; Tarko Rachel S; Vrouvlianis Joanna; Gu Jian; Dartt Darlene A
Nitric oxide and cGMP mediate alpha1D-adrenergic receptor-Stimulated protein secretion and p42/p44 MAPK activation in rat lacrimal gland.
Investigative ophthalmology & visual science 2005;46(8):2781-9.
2005: Ríos José David; Horikawa Yoshitaka; Chen Li-Li; Kublin Claire L; Hodges Robin R; Dartt Darlene A; Zoukhri Driss
Age-dependent alterations in mouse exorbital lacrimal gland structure, innervation and secretory response.
Experimental eye research 2005;80(4):477-91.
2005: Chen L L; Johansson J K; Hodges R R; Zoukhri D; Ghinelli E; Rios J D; Dartt D A
Differential effects of the EGF family of growth factors on protein secretion, MAPK activation, and intracellular calcium concentration in rat lacrimal gland.
Experimental eye research 2005;80(3):379-89.
2004: Hodges Robin R; Raddassi Isabelle; Zoukhri Driss; Toker Alex; Kazlauskas Andrius; Dartt Darlene A
Effect of overexpression of constitutively active PKCalpha on rat lacrimal gland protein secretion.
Investigative ophthalmology & visual science 2004;45(11):3974-81.
2004: Dartt Darlene A
Dysfunctional neural regulation of lacrimal gland secretion and its role in the pathogenesis of dry eye syndromes.
The ocular surface 2004;2(2):76-91.
2004: Dartt Darlene A
Interaction of EGF family growth factors and neurotransmitters in regulating lacrimal gland secretion.
Experimental eye research 2004;78(3):337-45.
2004: Usui Tomohiko; Ishida Susumu; Yamashiro Kenji; Kaji Yuichi; Poulaki Vasiliki; Moore Johnny; Moore Tara; Amano Shiro; Horikawa Yoshitaka; Dartt Darlene; Golding Matthew; Shima David T; Adamis Anthony P
VEGF164(165) as the pathological isoform: differential leukocyte and endothelial responses through VEGFR1 and VEGFR2.
Investigative ophthalmology & visual science 2004;45(2):368-74.
2004: Dartt Darlene A
Control of mucin production by ocular surface epithelial cells.
Experimental eye research 2004;78(2):173-85.
2003: Lee-Kwon Whaseon; Kim Jae Ho; Choi Jung Woong; Kawano Kazuya; Cha Boyoung; Dartt Darlene A; Zoukhri Driss; Donowitz Mark
Ca2+-dependent inhibition of NHE3 requires PKC alpha which binds to E3KARP to decrease surface NHE3 containing plasma membrane complexes.
American journal of physiology. Cell physiology 2003;285(6):C1527-36.
2003: Sohn U D; Park J H; Lee T S; Shin C Y; Jeong J H; Kim J H; Je H D; Dartt D A; Zoukhri D; Choi H C; Lee K Y
Differential regulation by Ca(2+) of calmodulin- and PKC-dependent contractile pathways in cat lower oesophageal sphincter.
Autonomic & autacoid pharmacology 2003;23(5-6):307-17.
2003: Ghinelli Emiliano; Johansson Jenny; Ríos José D; Chen Li-Li; Zoukhri Driss; Hodges Robin R; Dartt Darlene A
Presence and localization of neurotrophins and neurotrophin receptors in rat lacrimal gland.
Investigative ophthalmology & visual science 2003;44(8):3352-7.
2003: Horikawa Yoshitaka; Shatos Marie A; Hodges Robin R; Zoukhri Driss; Rios Jose D; Chang Eli L; Bernardino Carlo R; Rubin Peter A D; Dartt Darlene A
Activation of mitogen-activated protein kinase by cholinergic agonists and EGF in human compared with rat cultured conjunctival goblet cells.
Investigative ophthalmology & visual science 2003;44(6):2535-44.
2003: Shatos Marie A; Ríos José D; Horikawa Yoshitaka; Hodges Robin R; Chang Eli L; Bernardino Carlo R; Rubin Peter A D; Dartt Darlene A
Isolation and characterization of cultured human conjunctival goblet cells.
Investigative ophthalmology & visual science 2003;44(6):2477-86.
2003: Kanno Harumi; Horikawa Yoshitaka; Hodges Robin R; Zoukhri Driss; Shatos Marie A; Rios Jose D; Dartt Darlene A
Cholinergic agonists transactivate EGFR and stimulate MAPK to induce goblet cell secretion.
American journal of physiology. Cell physiology 2003;284(4):C988-98.
2003: Tepavcevic Vanja; Hodges Robin R; Zoukhri Driss; Dartt Darlene A
Signal transduction pathways used by EGF to stimulate protein secretion in rat lacrimal gland.
Investigative ophthalmology & visual science 2003;44(3):1075-81.
2003: Joussen Antonia M; Poulaki Vassiliki; Mitsiades Nicholas; Stechschulte Stephen U; Kirchhof Bernd; Dartt Darlene A; Fong Guo-Hua; Rudge John; Wiegand Stanley J; Yancopoulos George D; Adamis Anthony P
VEGF-dependent conjunctivalization of the corneal surface.
Investigative ophthalmology & visual science 2003;44(1):117-23.
2003: Ota Isao; Zoukhri Driss; Hodges Robin R; Rios José D; Tepavcevic Vanja; Raddassi Isabelle; Chen Li Li; Dartt Darlene A
Alpha 1-adrenergic and cholinergic agonists activate MAPK by separate mechanisms to inhibit secretion in lacrimal gland.
American journal of physiology. Cell physiology 2003;284(1):C168-78.
2003: Hodges Robin R; Dartt Darlene A
Regulatory pathways in lacrimal gland epithelium.
International review of cytology 2003;231():129-96.
2002: Xu Ke-Ping; Dartt Darlene A; Yu Fu-Shin X
EGF-induced ERK phosphorylation independent of PKC isozymes in human corneal epithelial cells.
Investigative ophthalmology & visual science 2002;43(12):3673-9.
2002: Dartt Darlene A
Regulation of mucin and fluid secretion by conjunctival epithelial cells.
Progress in retinal and eye research 2002;21(6):555-76.
2002: Shatos Marie A; Kano Harumi; Rubin Peter; Garza Gabriel; Dartt Darlene A
Isolation and characterization of human goblet cells in vitro: regulation of proliferation and activation of mitogen-activated protein kinase by EGF and carbachol.
Advances in experimental medicine and biology 2002;506(Pt A):301-5.
2002: Dartt Darlene A; Kanno Harumi; Rios Jose; Zoukhri Driss
Role of mitogen-activated protein kinase in cholinergic stimulation of conjunctival goblet cell secretion.
Advances in experimental medicine and biology 2002;506(Pt A):297-300.
2002: Hodges Robin R; Kazlauskas Andrius; Toker Alex; Dartt Darlene A
Effect of overexpression of protein kinase C alpha on rat lacrimal gland protein secretion.
Advances in experimental medicine and biology 2002;506(Pt A):237-41.
2002: Ríos José D; Ferdman Dina; Tepavcevic Vanja; Hodges Robin; Zoukhri Driss; Dartt Darlene A
Role of Ca2+ and protein kinase C in cholinergic, and alpha1-adrenergic agonists and EGF stimulated mitogen-activated protein kinase activity in lacrimal gland.
Advances in experimental medicine and biology 2002;506(Pt A):185-90.
2001: Dartt D A
Regulation of lacrimal gland secretion by neurotransmitters and the EGF family of growth factors.
Experimental eye research 2001;73(6):741-52.
2001: Diebold Y; Ríos J D; Hodges R R; Rawe I; Dartt D A
Presence of nerves and their receptors in mouse and human conjunctival goblet cells.
Investigative ophthalmology & visual science 2001;42(10):2270-82.
2001: Ang R T; Dartt D A; Tsubota K
Dry eye after refractive surgery.
Current opinion in ophthalmology 2001;12(4):318-22.
2001: Xu K P; Zoukhri D; Zieske J D; Dartt D A; Sergheraert C; Loing E; Yu F S
A role for MAP kinase in regulating ectodomain shedding of APLP2 in corneal epithelial cells.
American journal of physiology. Cell physiology 2001;281(2):C603-14.
2001: Shatos M A; Rios J D; Tepavcevic V; Kano H; Hodges R; Dartt D A
Isolation, characterization, and propagation of rat conjunctival goblet cells in vitro.
Investigative ophthalmology & visual science 2001;42(7):1455-64.
2000: Dartt D A; Rios J D; Kanno H; Rawe I M; Zieske J D; Ralda N; Hodges R R; Zoukhri D;
Regulation of conjunctival goblet cell secretion by Ca(2+)and protein kinase C.
Experimental eye research 2000;71(6):619-28.
2000: Graham M A; Rawe I; Dartt D A; Joyce N C
Protein kinase C regulation of corneal endothelial cell proliferation and cell cycle.
Investigative ophthalmology & visual science 2000;41(13):4124-32.
2000: Ríos J D; Forde K; Diebold Y; Lightman J; Zieske J D; Dartt D A
Development of conjunctival goblet cells and their neuroreceptor subtype expression.
Investigative ophthalmology & visual science 2000;41(8):2127-37.
2000: Zoukhri D; Hodges R R; Sergheraert C; Dartt D A
Cholinergic-induced Ca2+ elevation in rat lacrimal gland acini is negatively modulated by PKCdelta and PKCepsilon.
Investigative ophthalmology & visual science 2000;41(2):386-92.
1999: Thiam K; Loing E; Zoukhri D; Rommens C; Hodges R; Dartt D; Verwaerde C; Auriault C; Gras-Masse H; Sergheraert C
Direct evidence of cytoplasmic delivery of PKC-alpha, -epsilon and -zeta pseudosubstrate lipopeptides: study of their implication in the induction of apoptosis.
FEBS letters 1999;459(3):285-90.
1999: Ríos J D; Zoukhri D; Rawe I M; Hodges R R; Zieske J D; Dartt D A
Immunolocalization of muscarinic and VIP receptor subtypes and their role in stimulating goblet cell secretion.
Investigative ophthalmology & visual science 1999;40(6):1102-11.
1998: Zoukhri D; Hodges R R; Rawe I M; Dartt D A
Ca2+ signaling by cholinergic and alpha1-adrenergic agonists is up-regulated in lacrimal and submandibular glands in a murine model of Sjögren's syndrome.
Clinical immunology and immunopathology 1998;89(2):134-40.
1998: Zoukhri D; Hodges R R; Dartt D A
Lacrimal gland innervation is not altered with the onset and progression of disease in a murine model of Sjögren's syndrome.
Clinical immunology and immunopathology 1998;89(2):126-33.
1998: Zoukhri D; Hodges R R; Sergheraert C; Dartt D A
Lacrimal gland functions are differentially controlled by protein kinase C isoforms.
Annals of the New York Academy of Sciences 1998;842():217-20.
1998: Zoukhri D; Hodges R R; Sergheraert C; Dartt D A
Protein kinase C isoforms differentially control lacrimal gland functions.
Advances in experimental medicine and biology 1998;438():181-6.
1998: Hodges R R; Zoukhri D; Lightman J P; Dartt D A
Identification and cellular localization of the components of the VIP signaling pathway in the lacrimal gland.
Advances in experimental medicine and biology 1998;438():169-76.
1998: Dartt D A; Hodges R R; Zoukhri D
Signal transduction pathways activated by cholinergic and alpha 1-adrenergic agonists in the lacrimal gland.
Advances in experimental medicine and biology 1998;438():113-21.
1997: Zoukhri D; Hodges R R; Willert S; Dartt D A
Immunolocalization of lacrimal gland PKC isoforms. Effect of phorbol esters and cholinergic agonists on their cellular distribution.
The Journal of membrane biology 1997;157(2):169-75.
1997: Hodges R R; Zoukhri D; Sergheraert C; Zieske J D; Dartt D A
Identification of vasoactive intestinal peptide receptor subtypes in the lacrimal gland and their signal-transducing components.
Investigative ophthalmology & visual science 1997;38(3):610-9.
1997: Sohn U D; Zoukhri D; Dartt D; Sergheraert C; Harnett K M; Behar J; Biancani P
Different protein kinase C isozymes mediate lower esophageal sphincter tone and phasic contraction of esophageal circular smooth muscle.
Molecular pharmacology 1997;51(3):462-70.
1997: Zoukhri D; Hodges R R; Sergheraert C; Toker A; Dartt D A
Lacrimal gland PKC isoforms are differentially involved in agonist-induced protein secretion.
The American journal of physiology 1997;272(1 Pt 1):C263-9.
1996: Dartt D A; Kessler T L; Chung E H; Zieske J D
Vasoactive intestinal peptide-stimulated glycoconjugate secretion from conjunctival goblet cells.
Experimental eye research 1996;63(1):27-34.
1996: Dartt D A; Hodges R R; Zoukhri D; Mircheff A K
Protein phosphorylation in Golgi, endosomal, and endoplasmic reticulum membrane fractions of lacrimal gland.
Current eye research 1996;15(2):157-64.
1995: Dartt D A; McCarthy D M; Mercer H J; Kessler T L; Chung E H; Zieske J D
Localization of nerves adjacent to goblet cells in rat conjunctiva.
Current eye research 1995;14(11):993-1000.
1995: Kessler T L; Mercer H J; Zieske J D; McCarthy D M; Dartt D A
Stimulation of goblet cell mucous secretion by activation of nerves in rat conjunctiva.
Current eye research 1995;14(11):985-92.
1995: Zoukhri D; Dartt D A
Cholinergic activation of phospholipase D in lacrimal gland acini is independent of protein kinase C and calcium.
The American journal of physiology 1995;268(3 Pt 1):C713-20.
1994: Zoukhri D; Hodges R R; Dicker D M; Dartt D A
Role of protein kinase C in cholinergic stimulation of lacrimal gland protein secretion.
FEBS letters 1994;351(1):67-72.
1994: Dartt D A; Rose P E; Dicker D M; Ronco L V; Hodges R R
Alpha 1-adrenergic agonist-stimulated protein secretion in rat exorbital lacrimal gland acini.
Experimental eye research 1994;58(4):423-9.
1994: Hodges R R; Dicker D M; Dartt D A
Role of protein kinase C in alpha 1-adrenergic and cholinergic agonist stimulated protein secretion.
Advances in experimental medicine and biology 1994;350():147-50.
1994: Dartt D A
Regulation of tear secretion.
Advances in experimental medicine and biology 1994;350():1-9.
1994: Kessler T L; Dartt D A
Neural stimulation of conjunctival goblet cell mucous secretion in rats.
Advances in experimental medicine and biology 1994;350():393-8.
1992: Hodges R R; Dicker D M; Rose P E; Dartt D A
Alpha 1-adrenergic and cholinergic agonists use separate signal transduction pathways in lacrimal gland.
The American journal of physiology 1992;262(6 Pt 1):G1087-96.
1991: Gilbard J P; Rossi S R; Heyda K G; Dartt D A
Stimulation of tear secretion and treatment of dry-eye disease with 3-isobutyl-1-methylxanthine.
Archives of ophthalmology 1991;109(5):672-6.
1990: Dartt D A; Dicker D M; Ronco L V; Kjeldsen I M; Hodges R R; Murphy S A
Lacrimal gland inositol trisphosphate isomer and inositol tetrakisphosphate production.
The American journal of physiology 1990;259(2 Pt 1):G274-81.
1990: Gilbard J P; Rossi S R; Heyda K G; Dartt D A
Stimulation of tear secretion by topical agents that increase cyclic nucleotide levels.
Investigative ophthalmology & visual science 1990;31(7):1381-8.
1990: Rossi S R; Dartt D A; Gilbard J P
Eledoisin and lacrimal secretion in the rabbit.
Current eye research 1990;9(3):273-6.
1989: Dartt D A
Signal transduction and control of lacrimal gland protein secretion: a review.
Current eye research 1989;8(6):619-36.
1988: Dartt D A; Ronco L V; Murphy S A; Unser M F
Effect of phorbol esters on rat lacrimal gland protein secretion.
Investigative ophthalmology & visual science 1988;29(11):1726-31.
1988: Dartt D A; Baker A K; Rose P E; Murphy S A; Ronco L V; Unser M F
Role of cyclic AMP and Ca2+ in potentiation of rat lacrimal gland protein secretion.
Investigative ophthalmology & visual science 1988;29(11):1732-8.
1988: Gilbard J P; Dartt D A; Rood R P; Rossi S R; Gray K L; Donowitz M
Increased tear secretion in pancreatic cholera: a newly recognized symptom in an experiment of nature.
The American journal of medicine 1988;85(4):552-4.
1988: Dartt D A; Matkin C; Gray K
Comparison of proteins in lacrimal gland fluid secreted in response to different stimuli.
Investigative ophthalmology & visual science 1988;29(6):991-5.
1988: Dartt D A; Mircheff A K; Donowitz M; Sharp G W
Ca2+ - and cAMP-induced protein phosphorylation in lacrimal gland basolateral membranes.
The American journal of physiology 1988;254(4 Pt 1):G543-51.
1988: Dartt D A; Shulman M; Gray K L; Rossi S R; Matkin C; Gilbard J P
Stimulation of rabbit lacrimal gland secretion with biologically active peptides.
The American journal of physiology 1988;254(3 Pt 1):G300-6.
1985: Dartt D A; Rose P E; Joshi V M; Donowitz M; Sharp G W
Role of calcium in cholinergic stimulation of lacrimal gland protein secretion.
Current eye research 1985;4(4):475-83.
1984: Dartt D A; Baker A K; Vaillant C; Rose P E
Vasoactive intestinal polypeptide stimulation of protein secretion from rat lacrimal gland acini.
The American journal of physiology 1984;247(5 Pt 1):G502-9.
1982: Gilbard J P; Dartt D A
Changes in rabbit lacrimal gland fluid osmolarity with flow rate.
Investigative ophthalmology & visual science 1982;23(6):804-6.

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Darlene Dartt

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