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Zbigniew Darzynkiewicz

This is a preview profile on BiomedExperts - the first literature-based scientific social network. It brings the right researchers together and allows them to collaborate online. Collexis and Dell provide the BiomedExperts network of +1.5 Million pre-calculated profiles free of charge to researchers worldwide.

Research Profile (preview)

Procedures

Flow Cytometry

Physiology

Chemicals & Drugs

Anatomy

Disorders

DNA Damage

Phenomena

Phosphorylation

Concepts & Ideas

S Phase

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Co-Publications
Name
106
Traganos, Frank
39
Halicka, Dorota
30
Juan, Gloria
30
Bedner, Elzbieta
29
Huang, Xuan
29
Gorczyca, Wojciech
24
Ardelt, Barbara
24
Melamed, Myron
22
Li, X
22
Tanaka, Toshiki
17
Smolewski, Piotr
17
Dai, Wei
17
Grabarek, Jerzy
16
Pozarowski, Piotr
14
Hsieh, Tze-Chen

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Publications

TOP 3
Wlodkowic Donald; Skommer Joanna; McGuinness Dagmara; Hillier Chris; Darzynkiewicz Zbigniew
ER-Golgi network--a future target for anti-cancer therapy.
Halicka H Dorota; Darzynkiewicz Zbigniew; Teodori Laura
Attenuation of constitutive ATM activation and H2AX phosphorylation in human leukemic TK6 cells by their exposure to static magnetic field.
Zhao Hong; Albino Anthony P; Jorgensen Ellen; Traganos Frank; Darzynkiewicz Zbigniew
DNA damage response induced by tobacco smoke in normal human bronchial epithelial and A549 pulmonary adenocarcinoma cells assessed by laser scanning cytometry.

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All Publications

2009: Wlodkowic Donald; Skommer Joanna; McGuinness Dagmara; Hillier Chris; Darzynkiewicz Zbigniew
ER-Golgi network--a future target for anti-cancer therapy.
Leukemia research 2009;33(11):1440-7.
2009: Halicka H Dorota; Darzynkiewicz Zbigniew; Teodori Laura
Attenuation of constitutive ATM activation and H2AX phosphorylation in human leukemic TK6 cells by their exposure to static magnetic field.
Cell cycle (Georgetown, Tex.) 2009;8(19):3238-40.
2009: Zhao Hong; Albino Anthony P; Jorgensen Ellen; Traganos Frank; Darzynkiewicz Zbigniew
DNA damage response induced by tobacco smoke in normal human bronchial epithelial and A549 pulmonary adenocarcinoma cells assessed by laser scanning cytometry.
Cytometry. Part A : the journal of the International Society for Analytical Cytology 2009;75(10):840-7.
2009: Albino Anthony P; Jorgensen Ellen D; Rainey Patrick; Gillman Gene; Clark T Jeffrey; Gietl Diana; Zhao Hong; Traganos Frank; Darzynkiewicz Zbigniew
gammaH2AX: A potential DNA damage response biomarker for assessing toxicological risk of tobacco products.
Mutation research 2009;678(1):43-52.
2009: Halicka H Dorota; Smart Daniel J; Traganos Frank; Williams Gary M; Darzynkiewicz Zbigniew
Fluoroquinolones lower constitutive H2AX and ATM phosphorylation in TK6 lymphoblastoid cells via modulation of the intracellular redox status.
Pharmacological reports : PR 2009;61(4):711-8.
2009: Halicka H Dorota; Zhao Hong; Podhorecka Monika; Traganos Frank; Darzynkiewicz Zbigniew
Cytometric detection of chromatin relaxation, an early reporter of DNA damage response.
Cell cycle (Georgetown, Tex.) 2009;8(14):2233-7.
2009: Darzynkiewicz Zbigniew
Forever young, slim and fit: rapamycin to the rescue.
Cell cycle (Georgetown, Tex.) 2009;8(12):1820-1.
2009: Halicka H Dorota; Ozkaynak M Fevzi; Levendoglu-Tugal Oya; Sandoval Claudio; Seiter Karen; Kajstura Malgorzata; Traganos Frank; Jayabose Somasunadaram; Darzynkiewicz Zbigniew
DNA damage response as a biomarker in treatment of leukemias.
Cell cycle (Georgetown, Tex.) 2009;8(11):1720-4.
2009: Zhao Hong; Traganos Frank; Dobrucki Jurek; Wlodkowic Donald; Darzynkiewicz Zbigniew
Induction of DNA damage response by the supravital probes of nucleic acids.
Cytometry. Part A : the journal of the International Society for Analytical Cytology 2009;75(6):510-9.
2009: Hao Shoujin; Zhao Hong; Darzynkiewicz Zbigniew; Battula Sailaja; Ferreri Nicholas R
Expression and function of NFAT5 in medullary thick ascending limb (mTAL) cells.
American journal of physiology. Renal physiology 2009;296(6):F1494-503.
2009: Wlodkowic Donald; Skommer Joanna; Faley Shannon; Darzynkiewicz Zbigniew; Cooper Jonathan M
Dynamic analysis of apoptosis using cyanine SYTO probes: from classical to microfluidic cytometry.
Experimental cell research 2009;315(10):1706-14.
2009: Darzynkiewicz Zbigniew
An interview with Dr. Zbigniew Darzynkiewicz on his highly cited paper published in Cell Cycle.
Cell cycle (Georgetown, Tex.) 2009;8(10):1471-2.
2009: Halicka H Dorota; Mitlitski Vadim; Heeter Julie; Balazs Endre A; Darzynkiewicz Zbigniew
Attenuation of the oxidative burst-induced DNA damage in human leukocytes by hyaluronan.
International journal of molecular medicine 2009;23(5):695-9.
2009: Sato Yuichi; Kurose Akira; Ogawa Akira; Ogasawara Kuniaki; Traganos Frank; Darzynkiewicz Zbigniew; Sawai Takashi
Diversity of DNA damage response of astrocytes and glioblastoma cell lines with various p53 status to treatment with etoposide and temozolomide.
Cancer biology & therapy 2009;8(5):452-7.
2009: Darzynkiewicz Zbigniew; Halicka Dorota H; Tanaka Toshiki
Cytometric assessment of DNA damage induced by DNA topoisomerase inhibitors.
Methods in molecular biology (Clifton, N.J.) 2009;582():145-53.
2009: Wlodkowic Donald; Skommer Joanna; Darzynkiewicz Zbigniew
Flow cytometry-based apoptosis detection.
Methods in molecular biology (Clifton, N.J.) 2009;559():19-32.
2009: Tanaka Toshiki; Halicka Dorota; Traganos Frank; Darzynkiewicz Zbigniew
Cytometric analysis of DNA damage: phosphorylation of histone H2AX as a marker of DNA double-strand breaks (DSBs).
Methods in molecular biology (Clifton, N.J.) 2009;523():161-8.
2008: Zhao Hong; Ardelt Barbara; Ardelt Wojciech; Shogen Kuslima; Darzynkiewicz Zbigniew
The cytotoxic ribonuclease onconase targets RNA interference (siRNA).
Cell cycle (Georgetown, Tex.) 2008;7(20):3258-61.
2008: Darzynkiewicz Zbigniew
Pushing cancer cells to commit suicide: is 072RB, the new BH3 mimetic, up to the job?
Cell cycle (Georgetown, Tex.) 2008;7(20):3111.
2008: Zhao Hong; Traganos Frank; Darzynkiewicz Zbigniew
Phosphorylation of p53 on Ser15 during cell cycle caused by Topo I and Topo II inhibitors in relation to ATM and Chk2 activation.
Cell cycle (Georgetown, Tex.) 2008;7(19):3048-55.
2008: Wlodkowic Donald; Darzynkiewicz Zbigniew
Please do not disturb: destruction of chromatin structure by supravital nucleic acid probes revealed by a novel assay of DNA-histone interaction.
Cytometry. Part A : the journal of the International Society for Analytical Cytology 2008;73(10):877-9.
2008: Ita Masamichi; Halicka H Dorota; Tanaka Toshiki; Kurose Akira; Ardelt Barbara; Shogen Kuslima; Darzynkiewicz Zbigniew
Remarkable enhancement of cytotoxicity of onconase and cepharanthine when used in combination on various tumor cell lines.
Cancer biology & therapy 2008;7(7):1104-8.
2008: Zhao Hong; Tanaka Toshiki; Mitlitski Vadim; Heeter Julie; Balazs Endre A; Darzynkiewicz Zbigniew
Protective effect of hyaluronate on oxidative DNA damage in WI-38 and A549 cells.
International journal of oncology 2008;32(6):1159-67.
2008: Zhao Hong; Traganos Frank; Darzynkiewicz Zbigniew
Kinetics of histone H2AX phosphorylation and Chk2 activation in A549 cells treated with topotecan and mitoxantrone in relation to the cell cycle phase.
Cytometry. Part A : the journal of the International Society for Analytical Cytology 2008;73(6):480-9.
2008: Wlodkowic Donald; Skommer Joanna; Hillier Chris; Darzynkiewicz Zbigniew
Multiparameter detection of apoptosis using red-excitable SYTO probes.
Cytometry. Part A : the journal of the International Society for Analytical Cytology 2008;73(6):563-9.
2008: Pietrzak Monika; Halicka H Dorota; Wieczorek Zbigniew; Wieczorek Jolanta; Darzynkiewicz Zbigniew
Attenuation of acridine mutagen ICR-191--DNA interactions and DNA damage by the mutagen interceptor chlorophyllin.
Biophysical chemistry 2008;135(1-3):69-75.
2008: Wlodkowic Donald; Skommer Joanna; Darzynkiewicz Zbigniew
SYTO probes in the cytometry of tumor cell death.
Cytometry. Part A : the journal of the International Society for Analytical Cytology 2008;73(6):496-507.
2008: Smart Daniel J; Halicka H Dorota; Schmuck Gabriele; Traganos Frank; Darzynkiewicz Zbigniew; Williams Gary M
Assessment of DNA double-strand breaks and gammaH2AX induced by the topoisomerase II poisons etoposide and mitoxantrone.
Mutation research 2008;641(1-2):43-7.
2008: Zhao Hong; Traganos Frank; Albino Anthony P; Darzynkiewicz Zbigniew
Oxidative stress induces cell cycle-dependent Mre11 recruitment, ATM and Chk2 activation and histone H2AX phosphorylation.
Cell cycle (Georgetown, Tex.) 2008;7(10):1490-5.
2008: Darzynkiewicz Zbigniew
There's more than one way to skin a cat: yet another way to assess mitotic index by cytometry.
Cytometry. Part A : the journal of the International Society for Analytical Cytology 2008;73(5):386-7.
2008: Darzynkiewicz Zbigniew
Broken beyond repair. Damaging DNA in glioblastoma cells with radiation and camptothecin.
Cancer biology & therapy 2008;7(3):374-5.
2008: Wang Xiaoxing; Yang Yali; Duan Qing; Jiang Ning; Huang Ying; Darzynkiewicz Zbigniew; Dai Wei
sSgo1, a major splice variant of Sgo1, functions in centriole cohesion where it is regulated by Plk1.
Developmental cell 2008;14(3):331-41.
2008: Darzynkiewicz Zbigniew; Galkowski Dariusz; Zhao Hong
Analysis of apoptosis by cytometry using TUNEL assay.
Methods (San Diego, Calif.) 2008;44(3):250-4.
2008: Chen Sophie; Gao Jian; Halicka H Dorota; Traganos Frank; Darzynkiewicz Zbigniew
Down-regulation of androgen-receptor and PSA by phytochemicals.
International journal of oncology 2008;32(2):405-11.
2008: Halicka Dorota; Ita Masamichi; Tanaka Toshiki; Kurose Akira; Darzynkiewicz Zbigniew
Biscoclaurine alkaloid cepharanthine protects DNA in TK6 lymphoblastoid cells from constitutive oxidative damage.
Pharmacological reports : PR 2008;60(1):93-100.
2008: Smart Daniel J; Halicka H Dorota; Traganos Frank; Darzynkiewicz Zbigniew; Williams Gary M
Ciprofloxacin-induced G2 arrest and apoptosis in TK6 lymphoblastoid cells is not dependent on DNA double-strand break formation.
Cancer biology & therapy 2008;7(1):113-9.
2007: Ardelt Barbara; Ardelt Wojciech; Pozarowski Piotr; Kunicki Jan; Shogen Kuslima; Darzynkiewicz Zbigniew
Cytostatic and cytotoxic properties of Amphinase: a novel cytotoxic ribonuclease from Rana pipiens oocytes.
Cell cycle (Georgetown, Tex.) 2007;6(24):3097-102.
2007: Hsieh Tze-Chen; Traganos Frank; Darzynkiewicz Zbigniew; Wu Joseph M
The 2,6-disubstituted purine reversine induces growth arrest and polyploidy in human cancer cells.
International journal of oncology 2007;31(6):1293-300.
2007: Zhao Hong; Tanaka Toshiki; Halicka H Dorota; Traganos Frank; Zarebski Miroslaw; Dobrucki Jurek; Darzynkiewicz Zbigniew
Cytometric assessment of DNA damage by exogenous and endogenous oxidants reports aging-related processes.
Cytometry. Part A : the journal of the International Society for Analytical Cytology 2007;71(11):905-14.
2007: Tadi Kiranmayi; Ashok Badithe T; Chen Yuangen; Banerjee Debabrata; Wysocka-Skrzela Barbara; Konopa Jerzy; Darzynkiewicz Zbigniew; Tiwari Raj K
Pre-clinical evaluation of 1-nitroacridine derived chemotherapeutic agent that has preferential cytotoxic activity towards prostate cancer.
Cancer biology & therapy 2007;6(10):1632-7.
2007: Ardelt B; Juan G; Burfeind P; Salomon T; Wu J M; Hsieh T C; Li X; Sperry R; Pozarowski P; Shogen K; Ardelt W; Darzynkiewicz Z
Onconase, an anti-tumor ribonuclease suppresses intracellular oxidative stress.
International journal of oncology 2007;31(3):663-9.
2007: Tanaka Toshiki; Huang Xuan; Halicka H Dorota; Zhao Hong; Traganos Frank; Albino Anthony P; Dai Wei; Darzynkiewicz Zbigniew
Cytometry of ATM activation and histone H2AX phosphorylation to estimate extent of DNA damage induced by exogenous agents.
Cytometry. Part A : the journal of the International Society for Analytical Cytology 2007;71(9):648-61.
2007: Darzynkiewicz Zbigniew; Pozarowski Piotr
All that glitters is not gold: all that FLICA binds is not caspase. A caution in data interpretation--and new opportunities.
Cytometry. Part A : the journal of the International Society for Analytical Cytology 2007;71(8):536-7.
2007: Schulenburg Cindy; Ardelt Barbara; Ardelt Wojciech; Arnold Ulrich; Shogen Kuslima; Ulbrich-Hofmann Renate; Darzynkiewicz Zbigniew
The interdependence between catalytic activity, conformational stability, and cytotoxicity of onconase.
Cancer biology & therapy 2007;6(8):1233-9.
2007: Halicka H Dorota; Ardelt Barbara; Shogen Kuslima; Darzynkiewicz Zbigniew
Mild hyperthermia predisposes tumor cells to undergo apoptosis upon treatment with onconase.
International journal of oncology 2007;30(4):841-7.
2007: Kajstura Malgorzata; Halicka H Dorota; Pryjma Juliusz; Darzynkiewicz Zbigniew
Discontinuous fragmentation of nuclear DNA during apoptosis revealed by discrete "sub-G1" peaks on DNA content histograms.
Cytometry. Part A : the journal of the International Society for Analytical Cytology 2007;71(3):125-31.
2007: Tanaka Toshiki; Halicka H Dorota; Traganos Frank; Seiter Karen; Darzynkiewicz Zbigniew
Induction of ATM activation, histone H2AX phosphorylation and apoptosis by etoposide: relation to cell cycle phase.
Cell cycle (Georgetown, Tex.) 2007;6(3):371-6.
2007: Tanaka T; Kajstura M; Halicka H D; Traganos F; Darzynkiewicz Z
Constitutive histone H2AX phosphorylation and ATM activation are strongly amplified during mitogenic stimulation of lymphocytes.
Cell proliferation 2007;40(1):1-13.
2007: Lin Jane H-C; Takano Takahiro; Arcuino Gregory; Wang Xiaohai; Hu Furong; Darzynkiewicz Zbigniew; Nunes Marta; Goldman Steven A; Nedergaard Maiken
Purinergic signaling regulates neural progenitor cell expansion and neurogenesis.
Developmental biology 2007;302(1):356-66.
2007: Tanaka Toshiki; Huang Xuan; Jorgensen Ellen; Gietl Diana; Traganos Frank; Darzynkiewicz Zbigniew; Albino Anthony P
ATM activation accompanies histone H2AX phosphorylation in A549 cells upon exposure to tobacco smoke.
BMC cell biology 2007;8():26.
2006: Tanaka Toshiki; Halicka H Dorota; Traganos Frank; Darzynkiewicz Zbigniew
Phosphorylation of histone H2AX on Ser 139 and activation of ATM during oxidative burst in phorbol ester-treated human leukocytes.
Cell cycle (Georgetown, Tex.) 2006;5(22):2671-5.
2006: Mandecki Wlodek; Ardelt Barbara; Coradetti Thomas; Davidowitz Hanan; AFlint James A; Huang Zhili; MKopacka Wesley M; Lin Xin; Wang Zhuying; Darzynkiewicz Zbigniew
Microtransponders, the miniature RFID electronic chips, as platforms for cell growth in cytotoxicity assays.
Cytometry. Part A : the journal of the International Society for Analytical Cytology 2006;69(11):1097-105.
2006: Tanaka Toshiki; Halicka H Dorota; Huang Xuan; Traganos Frank; Darzynkiewicz Zbigniew
Constitutive histone H2AX phosphorylation and ATM activation, the reporters of DNA damage by endogenous oxidants.
Cell cycle (Georgetown, Tex.) 2006;5(17):1940-5.
2006: Tanaka T; Kurose A; Huang X; Traganos F; Dai W; Darzynkiewicz Z
Extent of constitutive histone H2AX phosphorylation on Ser-139 varies in cells with different TP53 status.
Cell proliferation 2006;39(4):313-23.
2006: Tanaka Toshiki; Kurose Akira; Halicka H Dorota; Huang Xuan; Traganos Frank; Darzynkiewicz Zbigniew
Nitrogen oxide-releasing aspirin induces histone H2AX phosphorylation, ATM activation and apoptosis preferentially in S-phase cells: involvement of reactive oxygen species.
Cell cycle (Georgetown, Tex.) 2006;5(15):1669-74.
2006: Huang Xuan; Tanaka Toshiki; Kurose Akira; Traganos Frank; Darzynkiewicz Zbigniew
Constitutive histone H2AX phosphorylation on Ser-139 in cells untreated by genotoxic agents is cell-cycle phase specific and attenuated by scavenging reactive oxygen species.
International journal of oncology 2006;29(2):495-501.
2006: Huang Xuan; Kurose Akira; Tanaka Toshiki; Traganos Frank; Dai Wei; Darzynkiewicz Zbigniew
Activation of ATM and histone H2AX phosphorylation induced by mitoxantrone but not by topotecan is prevented by the antioxidant N-acetyl-L-cysteine.
Cancer biology & therapy 2006;5(8):959-64.
2006: Pietrzak Monika; Wieczorek Zbigniew; Wieczorek Jolanta; Darzynkiewicz Zbigniew
The "interceptor" properties of chlorophyllin measured within the three-component system: intercalator-DNA-chlorophyllin.
Biophysical chemistry 2006;123(1):11-9.
2006: Albino Anthony P; Huang Xuan; Jorgensen Ellen D; Gietl Diana; Traganos Frank; Darzynkiewicz Zbigniew
Induction of DNA double-strand breaks in A549 and normal human pulmonary epithelial cells by cigarette smoke is mediated by free radicals.
International journal of oncology 2006;28(6):1491-505.
2006: Kurose A; Tanaka T; Huang X; Traganos F; Darzynkiewicz Z
Synchronization in the cell cycle by inhibitors of DNA replication induces histone H2AX phosphorylation: an indication of DNA damage.
Cell proliferation 2006;39(3):231-40.
2006: Fujii Nobuharu; Hiraki Akio; Aoe Keisuke; Murakami Tomoyuki; Ikeda Kazuma; Masuda Kozo; Matsuo Keitaro; Shinagawa Katsuji; Ishimaru Fumihiko; Sugi Kazuro; Darzynkiewicz Zbigniew; Tanimoto Mitsune
Serum cytokine concentrations and acute graft-versus-host disease after allogeneic peripheral blood stem cell transplantation: concurrent measurement of ten cytokines and their respective ratios using cytometric bead array.
International journal of molecular medicine 2006;17(5):881-5.
2006: Tanaka Toshiki; Kurose Akira; Halicka H Dorota; Traganos Frank; Darzynkiewicz Zbigniew
2-deoxy-D-glucose reduces the level of constitutive activation of ATM and phosphorylation of histone H2AX.
Cell cycle (Georgetown, Tex.) 2006;5(8):878-82.
2006: Huang Xuan; Kurose Akira; Tanaka Toshiki; Traganos Frank; Dai Wei; Darzynkiewicz Zbigniew
Sequential phosphorylation of Ser-10 on histone H3 and ser-139 on histone H2AX and ATM activation during premature chromosome condensation: relationship to cell-cycle phase and apoptosis.
Cytometry. Part A : the journal of the International Society for Analytical Cytology 2006;69(4):222-9.
2006: Kurose Akira; Tanaka Toshiki; Huang Xuan; Traganos Frank; Dai Wei; Darzynkiewicz Zbigniew
Effects of hydroxyurea and aphidicolin on phosphorylation of ataxia telangiectasia mutated on Ser 1981 and histone H2AX on Ser 139 in relation to cell cycle phase and induction of apoptosis.
Cytometry. Part A : the journal of the International Society for Analytical Cytology 2006;69(4):212-21.
2006: Jiang Ning; Wang Xiaoxing; Jhanwar-Uniyal Meena; Darzynkiewicz Zbigniew; Dai Wei
Polo box domain of Plk3 functions as a centrosome localization signal, overexpression of which causes mitotic arrest, cytokinesis defects, and apoptosis.
The Journal of biological chemistry 2006;281(15):10577-82.
2006: Gupte Rakhee S; Sampson Valerie; Traganos Frank; Darzynkiewicz Zbigniew; Lee Marietta Y W T
Cyclic AMP regulates the expression and nuclear translocation of RFC40 in MCF7 cells.
Experimental cell research 2006;312(6):796-806.
2006: Chen Jun; Huang Xuan; Halicka Dorota; Brodsky Sergey; Avram Ari; Eskander Jonathan; Bloomgarden Noah A; Darzynkiewicz Zbigniew; Goligorsky Michael S
Contribution of p16INK4a and p21CIP1 pathways to induction of premature senescence of human endothelial cells: permissive role of p53.
American journal of physiology. Heart and circulatory physiology 2006;290(4):H1575-86.
2006: Gupte Rakhee S; Traganos Frank; Darzynkiewicz Zbigniew; Lee Marietta Y W T
Phosphorylation of RIalpha by cyclin-dependent kinase CDK 2/cyclin E modulates the dissociation of the RIalpha-RFC40 complex.
Cell cycle (Georgetown, Tex.) 2006;5(6):653-60.
2006: Tanaka T; Kurose A; Huang X; Dai W; Darzynkiewicz Z
ATM activation and histone H2AX phosphorylation as indicators of DNA damage by DNA topoisomerase I inhibitor topotecan and during apoptosis.
Cell proliferation 2006;39(1):49-60.
2006: Pozarowski Piotr; Holden Elena; Darzynkiewicz Zbigniew
Laser scanning cytometry: principles and applications.
Methods in molecular biology (Clifton, N.J.) 2006;319():165-92.
2006: Darzynkiewicz Zbigniew; Huang Xuan; Okafuji Masaki
Detection of DNA strand breaks by flow and laser scanning cytometry in studies of apoptosis and cell proliferation (DNA replication).
Methods in molecular biology (Clifton, N.J.) 2006;314():81-93.
2006: Huang Xuan; Darzynkiewicz Zbigniew
Cytometric assessment of histone H2AX phosphorylation: a reporter of DNA damage.
Methods in molecular biology (Clifton, N.J.) 2006;314():73-80.
2005: Huang Hua-Shan; Pozarowski Piotr; Gao Yan; Darzynkiewicz Zbigniew; Lee Ernest Y C
Protein phosphatase-1 inhibitor-3 is co-localized to the nucleoli and centrosomes with PP1gamma1 and PP1alpha, respectively.
Archives of biochemistry and biophysics 2005;443(1-2):33-44.
2005: Jain Kavita; Roy Uzzal; Ardelt Barbara; Krishna U M; Falck J R; Pozarowski Piotr; Kunicki Jan; Darzynkiewicz Zbigniew; Balazy Michael
5E, 8Z, 11Z, 14Z-eicosatetraenoic acid, a novel trans isomer of arachidonic acid, causes G1 phase arrest and induces apoptosis of HL-60 cells.
International journal of oncology 2005;27(5):1177-85.
2005: Kurose Akira; Tanaka Toshiki; Huang Xuan; Halicka H Dorota; Traganos Frank; Dai Wei; Darzynkiewicz Zbigniew
Assessment of ATM phosphorylation on Ser-1981 induced by DNA topoisomerase I and II inhibitors in relation to Ser-139-histone H2AX phosphorylation, cell cycle phase, and apoptosis.
Cytometry. Part A : the journal of the International Society for Analytical Cytology 2005;68(1):1-9.
2005: Friedrich Thomas D; Bedner Elzbieta; Darzynkiewicz Zbigniew; Lehman John M
Distinct patterns of MCM protein binding in nuclei of S phase and rereplicating SV40-infected monkey kidney cells.
Cytometry. Part A : the journal of the International Society for Analytical Cytology 2005;68(1):10-8.
2005: Huang Xuan; Halicka H Dorota; Traganos Frank; Tanaka Toshiki; Kurose Akira; Darzynkiewicz Zbigniew
Cytometric assessment of DNA damage in relation to cell cycle phase and apoptosis.
Cell proliferation 2005;38(4):223-43.
2005: Huang Xuan; Dai Wei; Darzynkiewicz Zbigniew
Enforced adhesion of hematopoietic cells to culture dish induces endomitosis and polyploidy.
Cell cycle (Georgetown, Tex.) 2005;4(6):801-5.
2005: Demidenko Zoya N; Halicka Dorota; Kunicki Jan; McCubrey James A; Darzynkiewicz Zbigniew; Blagosklonny Mikhail V
Selective killing of adriamycin-resistant (G2 checkpoint-deficient and MRP1-expressing) cancer cells by docetaxel.
Cancer research 2005;65(10):4401-7.
2005: Gupte Rakhee S; Pozarowski Piotr; Grabarek Jerzy; Traganos Frank; Darzynkiewicz Zbigniew; Lee Marietta Y W T
RIalpha influences cellular proliferation in cancer cells by transporting RFC40 into the nucleus.
Cancer biology & therapy 2005;4(4):429-37.
2005: Chen Sophie; Gao Jian; Halicka H Dorota; Huang Xuan; Traganos Frank; Darzynkiewicz Zbigniew
The cytostatic and cytotoxic effects of oridonin (Rubescenin), a diterpenoid from Rabdosia rubescens, on tumor cells of different lineage.
International journal of oncology 2005;26(3):579-88.
2005: Halicka H Dorota; Huang Xuan; Traganos Frank; King Malcolm A; Dai Wei; Darzynkiewicz Zbigniew
Histone H2AX phosphorylation after cell irradiation with UV-B: relationship to cell cycle phase and induction of apoptosis.
Cell cycle (Georgetown, Tex.) 2005;4(2):339-45.
2005: Huang Xuan; Lee Brian; Johnson Gary; Naleway John; Guzikowski Anthony; Dai Wei; Darzynkiewicz Zbigniew
Novel assay utilizing fluorochrome-tagged physostigmine (Ph-F) to in situ detect active acetylcholinesterase (AChE) induced during apoptosis.
Cell cycle (Georgetown, Tex.) 2005;4(1):140-7.
2004: Tsai Shwu Y; Ardelt Barbara; Hsieh Tze-Chen; Darzynkiewicz Zbigniew; Shogen Kuslima; Wu Joseph M
Treatment of Jurkat acute T-lymphocytic leukemia cells by onconase (Ranpirnase) is accompanied by an altered nucleocytoplasmic distribution and reduced expression of transcription factor NF-kappaB.
International journal of oncology 2004;25(6):1745-52.
2004: King Malcolm A; Halicka H Dorota; Darzynkiewicz Zbigniew
Pro- and anti-apoptotic effects of an inhibitor of chymotrypsin-like serine proteases.
Cell cycle (Georgetown, Tex.) 2004;3(12):1566-71.
2004: Darzynkiewicz Zbigniew; Juan Gloria; Srour Edward F
Differential staining of DNA and RNA.
Current protocols in cytometry / editorial board, J. Paul Robinson, managing editor ... [et al.] 2004;Chapter 7():Unit 7.3.
2004: Huang Xuan; Halicka H Dorota; Darzynkiewicz Zbigniew
Detection of histone H2AX phosphorylation on Ser-139 as an indicator of DNA damage (DNA double-strand breaks).
Current protocols in cytometry / editorial board, J. Paul Robinson, managing editor ... [et al.] 2004;Chapter 7():Unit 7.27.
2004: Huang Xuan; King Malcolm A; Halicka H Dorota; Traganos Frank; Okafuji Masaki; Darzynkiewicz Zbigniew
Histone H2AX phosphorylation induced by selective photolysis of BrdU-labeled DNA with UV light: relation to cell cycle phase.
Cytometry. Part A : the journal of the International Society for Analytical Cytology 2004;62(1):1-7.
2004: Fu Yue; Hsieh Tze-chen; Guo Junqiao; Kunicki Jan; Lee Marietta Y W T; Darzynkiewicz Zbigniew; Wu Joseph M
Licochalcone-A, a novel flavonoid isolated from licorice root (Glycyrrhiza glabra), causes G2 and late-G1 arrests in androgen-independent PC-3 prostate cancer cells.
Biochemical and biophysical research communications 2004;322(1):263-70.
2004: Blagosklonny Mikhail V; Darzynkiewicz Zbigniew; Halicka H Dorota; Pozarowski Piotr; Demidenko Zoya N; Barry James J; Kamath Kalpana R; Herrmann Robert A
Paclitaxel induces primary and postmitotic G1 arrest in human arterial smooth muscle cells.
Cell cycle (Georgetown, Tex.) 2004;3(8):1050-6.
2004: Albino A P; Huang X; Jorgensen E; Yang J; Gietl D; Traganos F; Darzynkiewicz Z
Induction of H2AX phosphorylation in pulmonary cells by tobacco smoke: a new assay for carcinogens.
Cell cycle (Georgetown, Tex.) 2004;3(8):1062-8.
2004: Huang Xuan; Ruan Qin; Fang Yuqiang; Traganos Frank; Darzynkiewicz Zbigniew; Dai Wei
Physical and functional interactions between mitotic kinases during polyploidization and megakaryocytic differentiation.
Cell cycle (Georgetown, Tex.) 2004;3(7):946-51.
2004: Juan Gloria; Darzynkiewicz Zbigniew
Detection of mitotic cells.
Current protocols in cytometry / editorial board, J. Paul Robinson, managing editor ... [et al.] 2004;Chapter 7():Unit 7.24.
2004: Darzynkiewicz Zbigniew; Huang Xuan
Analysis of cellular DNA content by flow cytometry.
Current protocols in immunology / edited by John E. Coligan ... [et al.] 2004;Chapter 5():Unit 5.7.
2004: Hiraki Akio; Fujii Nobuharu; Murakami Tomoyuki; Kiura Katsuyuki; Aoe Keisuke; Yamane Hiromichi; Masuda Kozo; Maeda Tadashi; Sugi Kazuro; Darzynkiewicz Zbigniew; Tanimoto Mitsune; Harada Mine
High frequency of allele-specific down-regulation of HLA class I expression in lung cancer cell lines.
Anticancer research 2004;24(3a):1525-8.
2004: Huang Xuan; Okafuji Masaki; Traganos Frank; Luther Ed; Holden Elena; Darzynkiewicz Zbigniew
Assessment of histone H2AX phosphorylation induced by DNA topoisomerase I and II inhibitors topotecan and mitoxantrone and by the DNA cross-linking agent cisplatin.
Cytometry. Part A : the journal of the International Society for Analytical Cytology 2004;58(2):99-110.
2004: Darzynkiewicz Zbigniew; Crissman Harry; Jacobberger James W
Cytometry of the cell cycle: cycling through history.
Cytometry. Part A : the journal of the International Society for Analytical Cytology 2004;58(1):21-32.
2004: Ruan Qin; Wang Qi; Xie Suqing; Fang Yuqiang; Darzynkiewicz Zbigniew; Guan Kunliang; Jhanwar-Uniyal Meena; Dai Wei
Polo-like kinase 3 is Golgi localized and involved in regulating Golgi fragmentation during the cell cycle.
Experimental cell research 2004;294(1):51-9.
2004: Pozarowski Piotr; Grabarek Jerzy; Darzynkiewicz Zbigniew
Flow cytometry of apoptosis.
Current protocols in cell biology / editorial board, Juan S. Bonifacino ... [et al.] 2004;Chapter 18():Unit 18.8.
2004: Pozarowski Piotr; Huang Xuan; Gong Richard W; Priebe Waldemar; Darzynkiewicz Zbigniew
Simple, semiautomatic assay of cytostatic and cytotoxic effects of antitumor drugs by laser scanning cytometry: effects of the bis-intercalator WP631 on growth and cell cycle of T-24 cells.
Cytometry. Part A : the journal of the International Society for Analytical Cytology 2004;57(2):113-9.
2004: Wang Qi; Liu Tongyi; Fang Yuqiang; Xie Suqing; Huang Xuan; Mahmood Radma; Ramaswamy Gita; Sakamoto Kathleen M; Darzynkiewicz Zbigniew; Xu Ming; Dai Wei
BUBR1 deficiency results in abnormal megakaryopoiesis.
Blood 2004;103(4):1278-85.
2004: Darzynkiewicz Zbigniew; Huang Xuan; Okafuji Masaki; King Malcolm A
Cytometric methods to detect apoptosis.
Methods in cell biology 2004;75():307-41.
2004: Roederer Mario; Darzynkiewicz Zbigniew; Parks David R
Guidelines for the presentation of flow cytometric data.
Methods in cell biology 2004;75():241-56.
2004: Pozarowski Piotr; Darzynkiewicz Zbigniew
Analysis of cell cycle by flow cytometry.
Methods in molecular biology (Clifton, N.J.) 2004;281():301-11.
2003: Lee Brian W; Johnson Gary L; Hed Sally A; Darzynkiewicz Zbigniew; Talhouk Jamil W; Mehrotra Sanjiv
DEVDase detection in intact apoptotic cells using the cell permeant fluorogenic substrate, (z-DEVD)2-cresyl violet.
BioTechniques 2003;35(5):1080-5.
2003: Huang Xuan; Traganos Frank; Darzynkiewicz Zbigniew
DNA damage induced by DNA topoisomerase I- and topoisomerase II-inhibitors detected by histone H2AX phosphorylation in relation to the cell cycle phase and apoptosis.
Cell cycle (Georgetown, Tex.) 2003;2(6):614-9.
2003: Pozarowski P; Huang X; Halicka D H; Lee B; Johnson G; Darzynkiewicz Z
Interactions of fluorochrome-labeled caspase inhibitors with apoptotic cells: a caution in data interpretation.
Cytometry. Part A : the journal of the International Society for Analytical Cytology 2003;55(1):50-60.
2003: Abraham Nader G; Kushida Taketoshi; McClung Jack; Weiss Melvin; Quan Shuo; Lafaro Rocky; Darzynkiewicz Zbigniew; Wolin Michael
Heme oxygenase-1 attenuates glucose-mediated cell growth arrest and apoptosis in human microvessel endothelial cells.
Circulation research 2003;93(6):507-14.
2003: Pozarowski Piotr; Grabarek Jerzy; Darzynkiewicz Zbigniew
Flow cytometry of apoptosis.
Current protocols in cytometry / editorial board, J. Paul Robinson, managing editor ... [et al.] 2003;Chapter 7():Unit 7.19.
2003: Haider Asifa; Lee Irene; Grabarek Jerzy; Darzynkiewicz Zbigniew; Ferreri Nicholas R
Dual functionality of cyclooxygenase-2 as a regulator of tumor necrosis factor-mediated G1 shortening and nitric oxide-mediated inhibition of vascular smooth muscle cell proliferation.
Circulation 2003;108(8):1015-21.
2003: Pozarowski Piotr; Halicka Dorota H; Darzynkiewicz Zbigniew
NF-kappaB inhibitor sesquiterpene parthenolide induces concurrently atypical apoptosis and cell necrosis: difficulties in identification of dead cells in such cultures.
Cytometry. Part A : the journal of the International Society for Analytical Cytology 2003;54(2):118-24.
2003: Aoe Keisuke; Hiraki Akio; Murakami Tomoyuki; Murakami Kazuo; Makihata Kiyoshi; Takao Kazushi; Eda Ryosuke; Maeda Tadashi; Sugi Kazuro; Darzynkiewicz Zbigniew; Takeyama Hiroyasu
Relative abundance and patterns of correlation among six cytokines in pleural fluid measured by cytometric bead array.
International journal of molecular medicine 2003;12(2):193-8.
2003: Smolewski Piotr; Darzynkiewicz Zbigniew; Robak Tadeusz
Caspase-mediated cell death in hematological malignancies: theoretical considerations, methods of assessment, and clinical implications.
Leukemia & lymphoma 2003;44(7):1089-104.
2003: Pozarowski Piotr; Halicka Dorota H; Darzynkiewicz Zbigniew
Cell cycle effects and caspase-dependent and independent death of HL-60 and Jurkat cells treated with the inhibitor of NF-kappaB parthenolide.
Cell cycle (Georgetown, Tex.) 2003;2(4):377-83.
2003: Pietrzak Monika; Wieczorek Zbigniew; Stachelska Alicja; Darzynkiewicz Zbigniew
Interactions of chlorophyllin with acridine orange, quinacrine mustard and doxorubicin analyzed by light absorption and fluorescence spectroscopy.
Biophysical chemistry 2003;104(1):305-13.
2003: Haider Asifa S; Grabarek Jerzy; Eng Ben; Pedraza Paulina; Ferreri Nicholas R; Balazs Endre A; Darzynkiewicz Zbigniew
In vitro model of "wound healing" analyzed by laser scanning cytometry: accelerated healing of epithelial cell monolayers in the presence of hyaluronate.
Cytometry. Part A : the journal of the International Society for Analytical Cytology 2003;53(1):1-8.
2003: Blagosklonny Mikhail V; Darzynkiewicz Zbigniew
Why Iressa failed: toward novel use of kinase inhibitors (outlook).
Cancer biology & therapy 2003;2(2):137-40.
2003: Ardelt Barbara; Ardelt Wojciech; Darzynkiewicz Zbigniew
Cytotoxic ribonucleases and RNA interference (RNAi).
Cell cycle (Georgetown, Tex.) 2003;2(1):22-4.
2003: Strife Annabel; Wisniewski David; Liu Chongyuan; Lambek Caryl L; Darzynkiewicz Zbigniew; Silver Richard T; Clarkson Bayard
Direct evidence that Bcr-Abl tyrosine kinase activity disrupts normal synergistic interactions between Kit ligand and cytokines in primary primitive progenitor cells.
Molecular cancer research : MCR 2003;1(3):176-85.
2003: Darzynkiewicz Zbigniew; Juan Gloria; Traganos Frank
Cytometry of cell cycle regulatory proteins.
Progress in cell cycle research 2003;5():533-42.
2002: Halicka D H; Pozarowski P; Ita M; Ardelt W J; Mikulski S M; Shogen K; Darzynkiewicz Z
Enhancement of activation-induced apoptosis of lymphocytes by the cytotoxic ribonuclease onconase (Ranpirnase).
International journal of oncology 2002;21(6):1245-50.
2002: Blagosklonny Mikhail V; Darzynkiewicz Zbigniew
Cyclotherapy: protection of normal cells and unshielding of cancer cells.
Cell cycle (Georgetown, Tex.) 2002;1(6):375-82.
2002: Teodori Laura; Grabarek Jerzy; Smolewski Piotr; Ghibelli Lina; Bergamaschi Antonio; De Nicola Milena; Darzynkiewicz Zbigniew
Exposure of cells to static magnetic field accelerates loss of integrity of plasma membrane during apoptosis.
Cytometry 2002;49(3):113-8.
2002: Hsieh Tze-Chen; Kunicki Jan; Darzynkiewicz Zbigniew; Wu Joseph M
Effects of extracts of Coriolus versicolor (I'm-Yunity) on cell-cycle progression and expression of interleukins-1 beta,-6, and -8 in promyelocytic HL-60 leukemic cells and mitogenically stimulated and nonstimulated human lymphocytes.
Journal of alternative and complementary medicine (New York, N.Y.) 2002;8(5):591-602.
2002: Hsieh Tze; Halicka Dorota; Lu Xiaohua; Kunicki Jan; Guo Junqiao; Darzynkiewicz Zbigniew; Wu Joseph
Effects of resveratrol on the G(0)-G(1) transition and cell cycle progression of mitogenically stimulated human lymphocytes.
Biochemical and biophysical research communications 2002;297(5):1311-7.
2002: Grabarek Jerzy; Ardelt Barbara; Kunicki Jan; Darzynkiewicz Zbigniew
Detection of in situ activation of transglutaminase during apoptosis: correlation with the cell cycle phase by multiparameter flow and laser scanning cytometry.
Cytometry 2002;49(2):83-9.
2002: Blagosklonny Mikhail V; Robey Robert; Sackett Dan L; Du Litong; Traganos Frank; Darzynkiewicz Zbigniew; Fojo Tito; Bates Susan E
Histone deacetylase inhibitors all induce p21 but differentially cause tubulin acetylation, mitotic arrest, and cytotoxicity.
Molecular cancer therapeutics 2002;1(11):937-41.
2002: Darzynkiewicz Zbigniew
One more reason to get arrested (in G1).
Cell cycle (Georgetown, Tex.) 2002;1(5):318-9.
2002: Xie Suqing; Wang Qi; Luo Lu; Ruan Qin; Liu Tongyi; Jhanwar-Uniyal Meena; Darzynkiewicz Zbigniew; Traganos Frank; Dai Wei
Proteasome-dependent downregulation of p21(Waf1/Cip1) induced by reactive oxygen species.
Journal of interferon & cytokine research : the official journal of the International Society for Interferon and Cytokine Research 2002;22(9):957-63.
2002: Grabarek Jerzy; Darzynkiewicz Zbigniew
In situ activation of caspases and serine proteases during apoptosis detected by affinity labeling their enzyme active centers with fluorochrome-tagged inhibitors.
Experimental hematology 2002;30(9):982-9.
2002: Grabarek Jerzy; Ardelt Barbara; Du Litong; Darzynkiewicz Zbigniew
Activation of caspases and serine proteases during apoptosis induced by onconase (Ranpirnase).
Experimental cell research 2002;278(1):61-71.
2002: Blagosklonny Mikhail V; Darzynkiewicz Zbigniew; Figg William D
Flavopiridol inversely affects p21(WAF1/CIP1) and p53 and protects p21-sensitive cells from paclitaxel.
Cancer biology & therapy 2002;1(4):420-5.
2002: Blagosklonny Mikhail V; Darzynkiewicz Zbigniew
Four birds with one stone: RAPA as potential anticancer therapy.
Cancer biology & therapy 2002;1(4):359-61.
2002: Hsieh Tze-Chen; Xiong Wen; Traganos Frank; Darzynkiewicz Zbigniew; Wu Joseph M
Effects of PC-SPES on proliferation and expression of AR/PSA in androgen-responsive LNCaP cells are independent of estradiol.
Anticancer research 2002;22(4):2051-60.
2002: Smolewski Piotr; Grabarek Jerzy; Halicka H Dorota; Darzynkiewicz Zbigniew
Assay of caspase activation in situ combined with probing plasma membrane integrity to detect three distinct stages of apoptosis.
Journal of immunological methods 2002;265(1-2):111-21.
2002: Gorczyca Wojciech; Weisberger James; Liu Z; Tsang Patricia; Hossein Monowar; Wu C Daniel; Dong Henry; Wong John Y L; Tugulea Sorina; Dee Simpson; Melamed Myron R; Darzynkiewicz Zbigniew
An approach to diagnosis of T-cell lymphoproliferative disorders by flow cytometry.
Cytometry 2002;50(3):177-90.
2002: Halicka H Dorota; Smolewski Piotr; Darzynkiewicz Zbigniew; Dai Wei; Traganos Frank
Arsenic trioxide arrests cells early in mitosis leading to apoptosis.
Cell cycle (Georgetown, Tex.) 2002;1(3):201-9.
2002: Wang Qi; Xie Suqing; Chen Jie; Fukasawa Kenji; Naik Ulhas; Traganos Frank; Darzynkiewicz Zbigniew; Jhanwar-Uniyal Meena; Dai Wei
Cell cycle arrest and apoptosis induced by human Polo-like kinase 3 is mediated through perturbation of microtubule integrity.
Molecular and cellular biology 2002;22(10):3450-9.
2002: Tsai S Y; Hsieh T C; Ardelt B; Darzynkiewicz Z; Wu J M
Combined effects of onconase and IFN-beta on proliferation, macromolecular syntheses and expression of STAT-1 in JCA-1 cancer cells.
International journal of oncology 2002;20(5):891-6.
2002: Hsieh Tze-Chen; Lu Xiaohua; Guo Junqiao; Xiong Wen; Kunicki Jan; Darzynkiewicz Zbigniew; Wu Joseph M
Effects of herbal preparation Equiguard on hormone-responsive and hormone-refractory prostate carcinoma cells: mechanistic studies.
International journal of oncology 2002;20(4):681-9.
2002: Grabarek Jerzy; Du Litong; Johnson Gary L; Lee Brian W; Phelps David J; Darzynkiewicz Zbigniew
Sequential activation of caspases and serine proteases (serpases) during apoptosis.
Cell cycle (Georgetown, Tex.) 2002;1(2):124-31.
2002: Grabarek Jerzy; Amstad Paul; Darzynkiewicz Zbigniew
Use of fluorescently labeled caspase inhibitors as affinity labels to detect activated caspases.
Human cell : official journal of Human Cell Research Society 2002;15(1):1-12.
2002: Smolewski Piotr; Grabarek Jerzy; Lee Brian W; Johnson Gary L; Darzynkiewicz Zbigniew
Kinetics of HL-60 cell entry to apoptosis during treatment with TNF-alpha or camptothecin assayed by the stathmo-apoptosis method.
Cytometry 2002;47(3):143-9.
2002: Kapuscinski Jan; Ardelt Barbara; Piosik Jacek; Zdunek Malgorzata; Darzynkiewicz Zbigniew
The modulation of the DNA-damaging effect of polycyclic aromatic agents by xanthines. Part I. Reduction of cytostatic effects of quinacrine mustard by caffeine.
Biochemical pharmacology 2002;63(4):625-34.
2002: Grabarek Jerzy; Dragan Michal; Lee Brian W; Johnson Gary L; Darzynkiewicz Zbigniew
Activation of chymotrypsin-like serine protease(s) during apoptosis detected by affinity-labeling of the enzymatic center with fluoresceinated inhibitor.
International journal of oncology 2002;20(2):225-33.
2002: Guibal Florence C; Moog-Lutz Christel; Smolewski Piotr; Di Gioia Yolande; Darzynkiewicz Zbigniew; Lutz Pierre G; Cayre Yvon E
ASB-2 inhibits growth and promotes commitment in myeloid leukemia cells.
The Journal of biological chemistry 2002;277(1):218-24.
2002: Darzynkiewicz Zbigniew; Bedner Elzbieta; Smolewski Piotr
In situ detection of DNA strand breaks in analysis of apoptosis by flow- and laser-scanning cytometry.
Methods in molecular biology (Clifton, N.J.) 2002;203():69-77.
2002: Darzynkiewicz Zbigniew; Bedner Eizbieta; Smolewski Piotr; Lee Brian W; Johnson Gary L
Detection of caspases activation in situ by fluorochrome-labeled inhibitors of caspases (FLICA).
Methods in molecular biology (Clifton, N.J.) 2002;203():289-99.
2001: Darzynkiewicz Z; Smolewski P; Bedner E
Use of flow and laser scanning cytometry to study mechanisms regulating cell cycle and controlling cell death.
Clinics in laboratory medicine 2001;21(4):857-73.
2001: Gorczyca W; Smolewski P; Grabarek J; Ardelt B; Ita M; Melamed M R; Darzynkiewicz Z
Morphometry of nucleoli and expression of nucleolin analyzed by laser scanning cytometry in mitogenically stimulated lymphocytes.
Cytometry 2001;45(3):206-13.
2001: Chen S; Ruan Q; Bedner E; Deptala A; Wang X; Hsieh T C; Traganos F; Darzynkiewicz Z
Effects of the flavonoid baicalin and its metabolite baicalein on androgen receptor expression, cell cycle progression and apoptosis of prostate cancer cell lines.
Cell proliferation 2001;34(5):293-304.
2001: Du L; Smolewski P; Bedner E; Traganos F; Darzynkiewicz Z
Selective protection of mitogenically stimulated human lymphocytes but not leukemic cells from cytosine arabinoside-induced apoptosis by LY294002, a phosphoinositol-3 kinase inhibitor.
International journal of oncology 2001;19(4):811-9.
2001: Smolewski P; Grabarek J; Phelps D J; Darzynkiewicz Z
Stathmo-apoptosis: arresting apoptosis by fluorochrome-labeled inhibitor of caspases.
International journal of oncology 2001;19(4):657-63.
2001: Smolewski P; Grabarek J; Kamentsky L A; Darzynkiewicz Z
Bivariate analysis of cellular DNA versus RNA content by laser scanning cytometry using the product of signal subtraction (differential fluorescence) as a separate parameter.
Cytometry 2001;45(1):73-8.
2001: Smolewski P; Ruan Q; Vellon L; Darzynkiewicz Z
Micronuclei assay by laser scanning cytometry.
Cytometry 2001;45(1):19-26.
2001: Smolewski P; Bedner E; Gorczyca W; Darzynkiewicz Z
"Liquidless" cell staining by dye diffusion from gels and analysis by laser scanning cytometry: potential application at microgravity conditions in space.
Cytometry 2001;44(4):355-60.
2001: Juan G; Darzynkiewicz Z
Bivariate analysis of DNA content and expression of cyclin proteins.
Current protocols in cytometry / editorial board, J. Paul Robinson, managing editor ... [et al.] 2001;Chapter 7():Unit 7.9.
2001: Darzynkiewicz Z; Juan G
Analysis of DNA denaturation.
Current protocols in cytometry / editorial board, J. Paul Robinson, managing editor ... [et al.] 2001;Chapter 7():Unit 7.8.
2001: Darzynkiewicz Z; Juan G
Analysis of DNA content and BrdU incorporation.
Current protocols in cytometry / editorial board, J. Paul Robinson, managing editor ... [et al.] 2001;Chapter 7():Unit 7.7.
2001: Darzynkiewicz Z; Juan G
DNA content measurement for DNA ploidy and cell cycle analysis.
Current protocols in cytometry / editorial board, J. Paul Robinson, managing editor ... [et al.] 2001;Chapter 7():Unit 7.5.
2001: Darzynkiewicz Z; Juan G
Analysis of DNA content and DNA strand breaks for detection of apoptotic cells.
Current protocols in cytometry / editorial board, J. Paul Robinson, managing editor ... [et al.] 2001;Chapter 7():Unit 7.4.
2001: Darzynkiewicz Z; Juan G
Overview of nucleic acid analysis.
Current protocols in cytometry / editorial board, J. Paul Robinson, managing editor ... [et al.] 2001;Chapter 7():Unit 7.1.
2001: Darzynkiewicz Z; Juan G; Bedner E
Determining cell cycle stages by flow cytometry.
Current protocols in cell biology / editorial board, Juan S. Bonifacino ... [et al.] 2001;Chapter 8():Unit 8.4.
2001: Smolewski P; Bedner E; Du L; Hsieh T C; Wu J M; Phelps D J; Darzynkiewicz Z
Detection of caspases activation by fluorochrome-labeled inhibitors: Multiparameter analysis by laser scanning cytometry.
Cytometry 2001;44(1):73-82.
2001: Ardelt B; Kunicki J; Traganos F; Darzynkiewicz Z
Chlorophyllin protects cells from the cytostatic and cytotoxic effects of quinacrine mustard but not of nitrogen mustard.
International journal of oncology 2001;18(4):849-53.
2001: Bedner E; Du L; Traganos F; Darzynkiewicz Z
Caffeine dissociates complexes between DNA and intercalating dyes: application for bleaching fluorochrome-stained cells for their subsequent restaining and analysis by laser scanning cytometry.
Cytometry 2001;43(1):38-45.
2001: Darzynkiewicz Z; Li X; Bedner E
Use of flow and laser-scanning cytometry in analysis of cell death.
Methods in cell biology 2001;66():69-109.
2001: Deptala A; Bedner E; Darzynkiewicz Z
Unique analytical capabilities of laser scanning cytometry (LSC) that complement flow cytometry.
Folia histochemica et cytobiologica / Polish Academy of Sciences, Polish Histochemical and Cytochemical Society 2001;39(2):87-9.
2001: Darzynkiewicz Z; Juan G; Traganos F
Assaying drug-induced apoptosis.
Methods in molecular biology (Clifton, N.J.) 2001;95():241-54.
2001: Traganos F; Juan G; Darzynkiewicz Z
Cell-cycle analysis of drug-treated cells.
Methods in molecular biology (Clifton, N.J.) 2001;95():229-40.
2001: Gorczyca W; Deptala A; Bedner E; Li X; Melamed M R; Darzynkiewicz Z
Analysis of human tumors by laser scanning cytometry.
Methods in cell biology 2001;64():421-43.
2001: Darzynkiewicz Z; Bedner E; Traganos F
Difficulties and pitfalls in analysis of apoptosis.
Methods in cell biology 2001;63():527-46.
2001: Juan G; Traganos F; Darzynkiewicz Z
Methods to identify mitotic cells by flow cytometry.
Methods in cell biology 2001;63():343-54.
2000: Halicka H D; Murakami T; Papageorgio C N; Mittelman A; Mikulski S M; Shogen K; Darzynkiewicz Z
Induction of differentiation of leukaemic (HL-60) or prostate cancer (LNCaP, JCA-1) cells potentiates apoptosis triggered by onconase.
Cell proliferation 2000;33(6):407-17.
2000: Weisberger J; Wu C D; Liu Z; Wong J Y; Melamed M R; Darzynkiewicz Z; Gorczyca W
Differential diagnosis of malignant lymphomas and related disorders by specific pattern of expression of immunophenotypic markers revealed by multiparameter flow cytometry (Review).
International journal of oncology 2000;17(6):1165-77.
2000: Halicka H D; Bedner E; Darzynkiewicz Z
Segregation of RNA and separate packaging of DNA and RNA in apoptotic bodies during apoptosis.
Experimental cell research 2000;260(2):248-56.
2000: Abdel-Moneim I; Melamed M R; Darzynkiewicz Z; Gorczyca W
Proliferation and apoptosis in solid tumors. Analysis by laser scanning cytometry.
Analytical and quantitative cytology and histology / the International Academy of Cytology [and] American Society of Cytology 2000;22(5):393-7.
2000: Bedner E; Li X; Kunicki J; Darzynkiewicz Z
Translocation of Bax to mitochondria during apoptosis measured by laser scanning cytometry.
Cytometry 2000;41(2):83-8.
2000: DiPietrantonio A M; Hsieh T C; Juan G; Traganos F; Darzynkiewicz Z; Wu J M
Fenretinide-induced caspase 3 activity involves increased protein stability in a mechanism distinct from reactive oxygen species elevation.
Cancer research 2000;60(16):4331-5.
2000: Albino A P; Juan G; Traganos F; Reinhart L; Connolly J; Rose D P; Darzynkiewicz Z
Cell cycle arrest and apoptosis of melanoma cells by docosahexaenoic acid: association with decreased pRb phosphorylation.
Cancer research 2000;60(15):4139-45.
2000: Bedner E; Smolewski P; Amstad P; Darzynkiewicz Z
Activation of caspases measured in situ by binding of fluorochrome-labeled inhibitors of caspases (FLICA): correlation with DNA fragmentation.
Experimental cell research 2000;259(1):308-13.
2000: Bedner E; Ruan Q; Chen S; Kamentsky L A; Darzynkiewicz Z
Multiparameter analysis of progeny of individual cells by laser scanning cytometry.
Cytometry 2000;40(4):271-9.
2000: Feldman E J; Seiter K; Traganos F; Darzynkiewicz Z; Goff H; Pozzuoli M; Baskind P; Santos S; Ahmed T
Phase II evaluation of a high-dose mitoxantrone based induction regimen in untreated adults with acute myeloid leukemia.
Leukemia & lymphoma 2000;38(3-4):309-15.
2000: Li X; Du L; Darzynkiewicz Z
During apoptosis of HL-60 and U-937 cells caspases are activated independently of dissipation of mitochondrial electrochemical potential.
Experimental cell research 2000;257(2):290-7.
2000: Lin C W; Darzynkiewicz Z; Li X; Traganos F; Bedner E; Tse-Dinh Y C
Differential expression of human topoisomerase IIIalpha during the cell cycle progression in HL-60 leukemia cells and human peripheral blood lymphocytes.
Experimental cell research 2000;256(1):225-36.
2000: Kajstura J; Pertoldi B; Leri A; Beltrami C A; Deptala A; Darzynkiewicz Z; Anversa P
Telomere shortening is an in vivo marker of myocyte replication and aging.
The American journal of pathology 2000;156(3):813-9.
2000: Li X; Darzynkiewicz Z
Cleavage of Poly(ADP-ribose) polymerase measured in situ in individual cells: relationship to DNA fragmentation and cell cycle position during apoptosis.
Experimental cell research 2000;255(1):125-32.
2000: Seiter K; Feldman E J; Dorota Halicka H; Deptala A; Traganos F; Burke H B; Hoang A; Goff H; Pozzuoli M; Kancherla R; Darzynkiewicz Z; Ahmed T
Clinical and laboratory evaluation of all-trans retinoic acid modulation of chemotherapy in patients with acute myelogenous leukaemia.
British journal of haematology 2000;108(1):40-7.
2000: Darzynkiewicz Z; Bedner E
Analysis of apoptotic cells by flow and laser scanning cytometry.
Methods in enzymology 2000;322():18-39.
1999: Deptala A; Li X; Bedner E; Cheng W; Traganos F; Darzynkiewicz Z
Differences in induction of p53, p21WAF1 and apoptosis in relation to cell cycle phase of MCF-7 cells treated with camptothecin.
International journal of oncology 1999;15(5):861-71.
1999: Hsieh T C; Burfeind P; Laud K; Backer J M; Traganos F; Darzynkiewicz Z; Wu J M
Cell cycle effects and control of gene expression by resveratrol in human breast carcinoma cell lines with different metastatic potentials.
International journal of oncology 1999;15(2):245-52.
1999: Li X; Darzynkiewicz Z
The Schrödinger's cat quandary in cell biology: integration of live cell functional assays with measurements of fixed cells in analysis of apoptosis.
Experimental cell research 1999;249(2):404-12.
1999: Hsieh T C; Juan G; Darzynkiewicz Z; Wu J M
Resveratrol increases nitric oxide synthase, induces accumulation of p53 and p21(WAF1/CIP1), and suppresses cultured bovine pulmonary artery endothelial cell proliferation by perturbing progression through S and G2.
Cancer research 1999;59(11):2596-601.
1999: Bedner E; Halicka H D; Cheng W; Salomon T; Deptala A; Gorczyca W; Melamed M R; Darzynkiewicz Z
High affinity binding of fluorescein isothiocyanate to eosinophils detected by laser scanning cytometry: a potential source of error in analysis of blood samples utilizing fluorescein-conjugated reagents in flow cytometry.
Cytometry 1999;36(1):77-82.
1999: Darzynkiewicz Z; Bedner E; Li X; Gorczyca W; Melamed M R
Laser-scanning cytometry: A new instrumentation with many applications.
Experimental cell research 1999;249(1):1-12.
1999: Bedner E; Li X; Gorczyca W; Melamed M R; Darzynkiewicz Z
Analysis of apoptosis by laser scanning cytometry.
Cytometry 1999;35(3):181-95.
1999: Juan G; Traganos F; Darzynkiewicz Z
Histone H3 phosphorylation in human monocytes and during HL-60 cell differentiation.
Experimental cell research 1999;246(1):212-20.
1999: Darzynkiewicz Z; Li X; Bedner E
Detection of DNA strand breakage in the analysis of apoptosis and cell proliferation by flow and laser scanning cytometry.
Methods in molecular biology (Clifton, N.J.) 1999;113():607-19.
1999: Darzynkiewicz Z; Juan G
Selective extraction of fragmented DNA from apoptotic cells for analysis by gel electrophoresis and identification of apoptotic cells by flow cytometry.
Methods in molecular biology (Clifton, N.J.) 1999;113():599-605.
1998: Gorczyca W; Davidian M; Gherson J; Ashikari R; Darzynkiewicz Z; Melamed M R
Laser scanning cytometry quantification of estrogen receptors in breast cancer.
Analytical and quantitative cytology and histology / the International Academy of Cytology [and] American Society of Cytology 1998;20(6):470-6.
1998: Gorczyca W; Bedner E; Burfeind P; Darzynkiewicz Z; Melamed M R
Analysis of apoptosis in solid tumors by laser-scanning cytometry.
Modern pathology : an official journal of the United States and Canadian Academy of Pathology, Inc 1998;11(11):1052-8.
1998: Feldman E J; Seiter K; Chiao J W; Halicka H D; Traganos F; Fatora S R; McMichael J; Baskind P; Goff H; Beer M; Ahmed T; Darzynkiewicz Z
In vitro effects and clinical evaluation of a human chorionic gonadotrophin preparation in acute leukemia.
Leukemia : official journal of the Leukemia Society of America, Leukemia Research Fund, U.K 1998;12(11):1749-55.
1998: Deptala A; Bedner E; Gorczyca W; Darzynkiewicz Z
Activation of nuclear factor kappa B (NF-kappaB) assayed by laser scanning cytometry (LSC).
Cytometry 1998;33(3):376-82.
1998: Juan G; Li X; Darzynkiewicz Z
Phosphorylation of retinoblastoma protein assayed in individual HL-60 cells during their proliferation and differentiation.
Experimental cell research 1998;244(1):83-92.
1998: Mikulski S M; Viera A; Deptala A; Darzynkiewicz Z
Enhanced in vitro cytotoxicity and cytostasis of the combination of onconase with a proteasome inhibitor.
International journal of oncology 1998;13(4):633-44.
1998: Bedner E; Burfeind P; Hsieh T C; Wu J M; Aguero-Rosenfeld M E; Melamed M R; Horowitz H W; Wormser G P; Darzynkiewicz Z
Cell cycle effects and induction of apoptosis caused by infection of HL-60 cells with human granulocytic ehrlichiosis pathogen measured by flow and laser scanning cytometry.
Cytometry 1998;33(1):47-55.
1998: Bedner E; Melamed M R; Darzynkiewicz Z
Enzyme kinetic reactions and fluorochrome uptake rates measured in individual cells by laser scanning cytometry.
Cytometry 1998;33(1):1-9.
1998: Juan G; Ardelt B; Li X; Mikulski S M; Shogen K; Ardelt W; Mittelman A; Darzynkiewicz Z
G1 arrest of U937 cells by onconase is associated with suppression of cyclin D3 expression, induction of p16INK4A, p21WAF1/CIP1 and p27KIP and decreased pRb phosphorylation.
Leukemia : official journal of the Leukemia Society of America, Leukemia Research Fund, U.K 1998;12(8):1241-8.
1998: Deptala A; Halicka H D; Ardelt B; Ardelt W; Mikulski S M; Shogen K; Darzynkiewicz Z
Potentiation of tumor necrosis factor induced apoptosis by onconase.
International journal of oncology 1998;13(1):11-6.
1998: Juan G; Traganos F; James W M; Ray J M; Roberge M; Sauve D M; Anderson H; Darzynkiewicz Z
Histone H3 phosphorylation and expression of cyclins A and B1 measured in individual cells during their progression through G2 and mitosis.
Cytometry 1998;32(2):71-7.
1998: Darzynkiewicz Z; Bedner E; Traganos F; Murakami T
Critical aspects in the analysis of apoptosis and necrosis.
Human cell : official journal of Human Cell Research Society 1998;11(1):3-12.
1998: Juan G; Gruenwald S; Darzynkiewicz Z
Phosphorylation of retinoblastoma susceptibility gene protein assayed in individual lymphocytes during their mitogenic stimulation.
Experimental cell research 1998;239(1):104-10.
1998: Darzynkiewicz Z; Traganos F
Measurement of apoptosis.
Advances in biochemical engineering/biotechnology 1998;62():33-73.
1998: Gorczyca W; Melamed M R; Darzynkiewicz Z
Analysis of apoptosis by flow cytometry.
Methods in molecular biology (Clifton, N.J.) 1998;91():217-38.
1998: Juan G; Darzynkiewicz Z
Detection of cyclins in individual cells by flow and laser scanning cytometry.
Methods in molecular biology (Clifton, N.J.) 1998;91():67-75.
1997: Haider S R; Juan G; Traganos F; Darzynkiewicz Z
Immunoseparation and immunodetection of nucleic acids labeled with halogenated nucleotides.
Experimental cell research 1997;234(2):498-506.
1997: Gorczyca W; Sarode V; Juan G; Melamed M R; Darzynkiewicz Z
Laser scanning cytometric analysis of cyclin B1 in primary human malignancies.
Modern pathology : an official journal of the United States and Canadian Academy of Pathology, Inc 1997;10(5):457-62.
1997: Vibhakar R; Juan G; Traganos F; Darzynkiewicz Z; Finger L R
Activation-induced expression of human programmed death-1 gene in T-lymphocytes.
Experimental cell research 1997;232(1):25-8.
1997: Juan G; Li X; Darzynkiewicz Z
Correlation between DNA replication and expression of cyclins A and B1 in individual MOLT-4 cells.
Cancer research 1997;57(5):803-7.
1997: Gorczyca W; Darzynkiewicz Z; Melamed M R
Laser scanning cytometry in pathology of solid tumors. A review.
Acta cytologica 1997;41(1):98-108.
1997: Darzynkiewicz Z; Juan G; Li X; Gorczyca W; Murakami T; Traganos F
Cytometry in cell necrobiology: analysis of apoptosis and accidental cell death (necrosis).
Cytometry 1997;27(1):1-20.
1996: Traganos F; Seiter K; Feldman E; Halicka H D; Darzynkiewicz Z
Induction of apoptosis by camptothecin and topotecan.
Annals of the New York Academy of Sciences 1996;803():101-10.
1996: Darzynkiewicz Z; Bruno S; Del Bino G; Traganos F
The cell cycle effects of camptothecin.
Annals of the New York Academy of Sciences 1996;803():93-100.
1996: Gorczyca W; Melamed M R; Darzynkiewicz Z
Laser scanning cytometer (LSC) analysis of fraction of labelled mitoses (FLM).
Cell proliferation 1996;29(10):539-47.
1996: Darzynkiewicz Z; Gong J; Juan G; Ardelt B; Traganos F
Cytometry of cyclin proteins.
Cytometry 1996;25(1):1-13.
1996: Juan G; Pan W; Darzynkiewicz Z
DNA segments sensitive to single-strand-specific nucleases are present in chromatin of mitotic cells.
Experimental cell research 1996;227(2):197-202.
1996: Juan G; Gong J; Traganos F; Darzynkiewicz Z
Unscheduled expression of cyclins D1 and D3 in human tumour cell lines.
Cell proliferation 1996;29(5):259-66.
1996: Hara S; Halicka H D; Bruno S; Gong J; Traganos F; Darzynkiewicz Z
Effect of protease inhibitors on early events of apoptosis.
Experimental cell research 1996;223(2):372-84.
1996: Li X; Melamed M R; Darzynkiewicz Z
Detection of apoptosis and DNA replication by differential labeling of DNA strand breaks with fluorochromes of different color.
Experimental cell research 1996;222(1):28-37.
1995: Gong J; Traganos F; Darzynkiewicz Z
Growth imbalance and altered expression of cyclins B1, A, E, and D3 in MOLT-4 cells synchronized in the cell cycle by inhibitors of DNA replication.
Cell growth & differentiation : the molecular biology journal of the American Association for Cancer Research 1995;6(11):1485-93.
1995: Li X; Darzynkiewicz Z
Labelling DNA strand breaks with BrdUTP. Detection of apoptosis and cell proliferation.
Cell proliferation 1995;28(11):571-9.
1995: Seiter K; Feldman E J; Traganos F; Li X; Halicka H D; Darzynkiewicz Z; Lederman C A; Romero M B; Ahmed T
Evaluation of in vivo induction of apoptosis in patients with acute leukemia treated on a phase I study of paclitaxel.
Leukemia : official journal of the Leukemia Society of America, Leukemia Research Fund, U.K 1995;9(11):1961-6.
1995: Li X; James W M; Traganos F; Darzynkiewicz Z
Application of biotin, digoxigenin or fluorescein conjugated deoxynucleotides to label DNA strand breaks for analysis of cell proliferation and apoptosis using flow cytometry.
Biotechnic & histochemistry : official publication of the Biological Stain Commission 1995;70(5):234-42.
1995: Gong J; Traganos F; Darzynkiewicz Z
Discrimination of G2 and mitotic cells by flow cytometry based on different expression of cyclins A and B1.
Experimental cell research 1995;220(1):226-31.
1995: Bhatia U; Danishefsky K; Traganos F; Darzynkiewicz Z
Induction of apoptosis and cell cycle-specific change in expression of p53 in normal lymphocytes and MOLT-4 leukemic cells by nitrogen mustard.
Clinical cancer research : an official journal of the American Association for Cancer Research 1995;1(8):873-80.
1995: Bhatia U; Traganos F; Darzynkiewicz Z
Induction of cell differentiation potentiates apoptosis triggered by prior exposure to DNA-damaging drugs.
Cell growth & differentiation : the molecular biology journal of the American Association for Cancer Research 1995;6(8):937-44.
1995: Murakami T; Li X; Gong J; Bhatia U; Traganos F; Darzynkiewicz Z
Induction of apoptosis by 5-azacytidine: drug concentration-dependent differences in cell cycle specificity.
Cancer research 1995;55(14):3093-8.
1995: Li X; Traganos F; Melamed M R; Darzynkiewicz Z
Single-step procedure for labeling DNA strand breaks with fluorescein- or BODIPY-conjugated deoxynucleotides: detection of apoptosis and bromodeoxyuridine incorporation.
Cytometry 1995;20(2):172-80.
1995: Gong J; Traganos F; Darzynkiewicz Z
Threshold expression of cyclin E but not D type cyclins characterizes normal and tumour cells entering S phase.
Cell proliferation 1995;28(6):337-46.
1995: Qiao L; Gorczyca W; Pizzolo J G; Melamed M R; Darzynkiewicz Z
Flow cytometric characterization of proliferation-associated nuclear antigen (p105) during the cell cycle in normal lymphocytes and promyelocytic leukemia cells (HL-60).
Analytical and quantitative cytology and histology / the International Academy of Cytology [and] American Society of Cytology 1995;17(3):183-8.
1995: Gong J; Bhatia U; Traganos F; Darzynkiewicz Z
Expression of cyclins A, D2 and D3 in individual normal mitogen stimulated lymphocytes and in MOLT-4 leukemic cells analyzed by multiparameter flow cytometry.
Leukemia : official journal of the Leukemia Society of America, Leukemia Research Fund, U.K 1995;9(5):893-9.
1995: Halicka H D; Ardelt B; Li X; Melamed M M; Darzynkiewicz Z
2-Deoxy-D-glucose enhances sensitivity of human histiocytic lymphoma U937 cells to apoptosis induced by tumor necrosis factor.
Cancer research 1995;55(2):444-9.
1994: Li X; Traganos F; Darzynkiewicz Z
Simultaneous analysis of DNA replication and apoptosis during treatment of HL-60 cells with camptothecin and hyperthermia and mitogen stimulation of human lymphocytes.
Cancer research 1994;54(16):4289-93.
1994: Gong J; Ardelt B; Traganos F; Darzynkiewicz Z
Unscheduled expression of cyclin B1 and cyclin E in several leukemic and solid tumor cell lines.
Cancer research 1994;54(16):4285-8.
1994: Gong J; Traganos F; Darzynkiewicz Z
Staurosporine blocks cell progression through G1 between the cyclin D and cyclin E restriction points.
Cancer research 1994;54(12):3136-9.
1994: Gong J; Traganos F; Darzynkiewicz Z
A selective procedure for DNA extraction from apoptotic cells applicable for gel electrophoresis and flow cytometry.
Analytical biochemistry 1994;218(2):314-9.
1994: Hotz M A; Gong J; Traganos F; Darzynkiewicz Z
Flow cytometric detection of apoptosis: comparison of the assays of in situ DNA degradation and chromatin changes.
Cytometry 1994;15(3):237-44.
1994: Traganos F; Gong J; Ardelt B; Darzynkiewicz Z
Effect of staurosporine on MOLT-4 cell progression through G2 and on cytokinesis.
Journal of cellular physiology 1994;158(3):535-44.
1994: Gorczyca W; Tuziak T; Kram A; Melamed M R; Darzynkiewicz Z
Detection of apoptosis-associated DNA strand breaks in fine-needle aspiration biopsies by in situ end labeling of fragmented DNA.
Cytometry 1994;15(2):169-75.
1994: Darzynkiewicz Z; Gong J; Traganos F
Analysis of DNA content and cyclin protein expression in studies of DNA ploidy, growth fraction, lymphocyte stimulation, and the cell cycle.
Methods in cell biology 1994;41():421-35.
1994: Darzynkiewicz Z; Li X; Gong J
Assays of cell viability: discrimination of cells dying by apoptosis.
Methods in cell biology 1994;41():15-38.
1994: Darzynkiewicz Z
Acid-induced denaturation of DNA in situ as a probe of chromatin structure.
Methods in cell biology 1994;41():527-41.
1994: Darzynkiewicz Z
Simultaneous analysis of cellular RNA and DNA content.
Methods in cell biology 1994;41():401-20.
1994: Traganos F; Darzynkiewicz Z
Lysosomal proton pump activity: supravital cell staining with acridine orange differentiates leukocyte subpopulations.
Methods in cell biology 1994;41():185-94.
1994: Lassota P; Kazimierczuk Z; Darzynkiewicz Z
Apoptotic death of lymphocytes upon treatment with 2-chloro-2'-deoxyadenosine (2-CdA).
Archivum immunologiae et therapiae experimentalis 1994;42(1):17-23.
1993: Gong J; Li X; Darzynkiewicz Z
Different patterns of apoptosis of HL-60 cells induced by cycloheximide and camptothecin.
Journal of cellular physiology 1993;157(2):263-70.
1993: Gong J; Traganos F; Darzynkiewicz Z
Simultaneous analysis of cell cycle kinetics at two different DNA ploidy levels based on DNA content and cyclin B measurements.
Cancer research 1993;53(21):5096-9.
1993: Traganos F; Kapuscinski J; Gong J; Ardelt B; Darzynkiewicz R J; Darzynkiewicz Z
Caffeine prevents apoptosis and cell cycle effects induced by camptothecin or topotecan in HL-60 cells.
Cancer research 1993;53(19):4613-8.
1993: Strife A; Perez A; Lambek C; Wisniewski D; Bruno S; Darzynkiewicz Z; Clarkson B
Differences in the composition and in the efficiency of red cell production of normal and CML erythroid progenitor populations are highlighted by response to human c-kit ligand.
Leukemia research 1993;17(9):799-807.
1993: Gorczyca W; Traganos F; Jesionowska H; Darzynkiewicz Z
Presence of DNA strand breaks and increased sensitivity of DNA in situ to denaturation in abnormal human sperm cells: analogy to apoptosis of somatic cells.
Experimental cell research 1993;207(1):202-5.
1993: Gorczyca W; Gong J; Ardelt B; Traganos F; Darzynkiewicz Z
The cell cycle related differences in susceptibility of HL-60 cells to apoptosis induced by various antitumor agents.
Cancer research 1993;53(13):3186-92.
1993: Gorczyca W; Bigman K; Mittelman A; Ahmed T; Gong J; Melamed M R; Darzynkiewicz Z
Induction of DNA strand breaks associated with apoptosis during treatment of leukemias.
Leukemia : official journal of the Leukemia Society of America, Leukemia Research Fund, U.K 1993;7(5):659-70.
1993: Gorczyca W; Gong J; Darzynkiewicz Z
Detection of DNA strand breaks in individual apoptotic cells by the in situ terminal deoxynucleotidyl transferase and nick translation assays.
Cancer research 1993;53(8):1945-51.
1993: Gorczyca W; Melamed M R; Darzynkiewicz Z
Apoptosis of S-phase HL-60 cells induced by DNA topoisomerase inhibitors: detection of DNA strand breaks by flow cytometry using the in situ nick translation assay.
Toxicology letters 1993;67(1-3):249-58.
1993: Darzynkiewicz Z; Gorczyca W; Lassota P; Traganos F
Altered sensitivity of DNA in situ to denaturation in apoptotic cells.
Annals of the New York Academy of Sciences 1993;677():334-40.
1993: Strife A; Perez A; Lambek C; Wisniewski D; Bruno S; Darzynkiewicz Z; Clarkson B
Characterization of lineage-negative blast subpopulations derived from normal and chronic myelogenous leukemia bone marrows and determination of their responsiveness to human c-kit ligand.
Cancer research 1993;53(2):401-9.
1993: Gorczyca W; Kram A; Tuziak T; Darzynkiewicz Z; Melamed M R
Proliferating cell nuclear antigen in archival surgical specimens of malignant lymphoma and metastatic carcinoma: immunohistochemical and flow cytometric analysis.
Patologia polska 1993;44(3):121-8.
1992: Del Bino G; Bruno S; Yi P N; Darzynkiewicz Z
Apoptotic cell death triggered by camptothecin or teniposide. The cell cycle specificity and effects of ionizing radiation.
Cell proliferation 1992;25(6):537-48.
1992: Traganos F; Ardelt B; Halko N; Bruno S; Darzynkiewicz Z
Effects of genistein on the growth and cell cycle progression of normal human lymphocytes and human leukemic MOLT-4 and HL-60 cells.
Cancer research 1992;52(22):6200-8.
1992: Bruno S; Del Bino G; Lassota P; Giaretti W; Darzynkiewicz Z
Inhibitors of proteases prevent endonucleolysis accompanying apoptotic death of HL-60 leukemic cells and normal thymocytes.
Leukemia : official journal of the Leukemia Society of America, Leukemia Research Fund, U.K 1992;6(11):1113-20.
1992: Mikulski S M; Viera A; Darzynkiewicz Z; Shogen K
Synergism between a novel amphibian oocyte ribonuclease and lovastatin in inducing cytostatic and cytotoxic effects in human lung and pancreatic carcinoma cell lines.
British journal of cancer 1992;66(2):304-10.
1992: Hotz M A; Traganos F; Darzynkiewicz Z
Changes in nuclear chromatin related to apoptosis or necrosis induced by the DNA topoisomerase II inhibitor fostriecin in MOLT-4 and HL-60 cells are revealed by altered DNA sensitivity to denaturation.
Experimental cell research 1992;201(1):184-91.
1992: Gorczyca W; Bruno S; Melamed M R; Darzynkiewicz Z
Cell cycle-related expression of p120 nucleolar antigen in normal human lymphocytes and in cells of HL-60 and MOLT-4 leukemic lines: effects of methotrexate, camptothecin, and teniposide.
Cancer research 1992;52(12):3491-4.
1992: Bruno S; Giaretti W; Darzynkiewicz Z
Effect of camptothecin on mitogenic stimulation of human lymphocytes: involvement of DNA topoisomerase I in cell transition from G0 to G1 phase of the cell cycle and in DNA replication.
Journal of cellular physiology 1992;151(3):478-86.
1992: Rivas C I; Wisniewski D; Strife A; Perez A; Lambek C; Bruno S; Darzynkiewicz Z; Clarkson B
Constitutive expression of p53 protein in enriched normal human marrow blast cell populations.
Blood 1992;79(8):1982-6.
1992: Hotz M A; Del Bino G; Lassota P; Traganos F; Darzynkiewicz Z
Cytostatic and cytotoxic effects of fostriecin on human promyelocytic HL-60 and lymphocytic MOLT-4 leukemic cells.
Cancer research 1992;52(6):1530-5.
1992: Bruno S; Ardelt B; Skierski J S; Traganos F; Darzynkiewicz Z
Different effects of staurosporine, an inhibitor of protein kinases, on the cell cycle and chromatin structure of normal and leukemic lymphocytes.
Cancer research 1992;52(2):470-3.
1992: Bruno S; Darzynkiewicz Z
Cell cycle dependent expression and stability of the nuclear protein detected by Ki-67 antibody in HL-60 cells.
Cell proliferation 1992;25(1):31-40.
1992: Bruno S; Lassota P; Giaretti W; Darzynkiewicz Z
Apoptosis of rat thymocytes triggered by prednisolone, camptothecin, or teniposide is selective to G0 cells and is prevented by inhibitors of proteases.
Oncology research 1992;4(1):29-35.
1992: Bruno S; Gorczyca W; Darzynkiewicz Z
Effect of ionic strength in immunocytochemical detection of the proliferation associated nuclear antigens p120, PCNA, and the protein reacting with Ki-67 antibody.
Cytometry 1992;13(5):496-501.
1992: Darzynkiewicz Z; Bruno S; Del Bino G; Gorczyca W; Hotz M A; Lassota P; Traganos F
Features of apoptotic cells measured by flow cytometry.
Cytometry 1992;13(8):795-808.
1991: Strife A; Lambek C; Perez A; Darzynkiewicz Z; Skierski J; Gulati S; Haley J D; ten Dijke P; Iwata K K; Clarkson B D
The effects of transforming growth factor beta 3 on the growth of highly enriched hematopoietic progenitor cells derived from normal human bone marrow and peripheral blood.
Cancer research 1991;51(18):4828-36.
1991: Bruno S; Crissman H A; Bauer K D; Darzynkiewicz Z
Changes in cell nuclei during S phase: progressive chromatin condensation and altered expression of the proliferation-associated nuclear proteins Ki-67, cyclin (PCNA), p105, and p34.
Experimental cell research 1991;196(1):99-106.
1991: Del Bino G; Skierski J S; Darzynkiewicz Z
The concentration-dependent diversity of effects of DNA topoisomerase I and II inhibitors on the cell cycle of HL-60 cells.
Experimental cell research 1991;195(2):485-91.
1991: Traganos F; Kapuscinski J; Darzynkiewicz Z
Caffeine modulates the effects of DNA-intercalating drugs in vitro: a flow cytometric and spectrophotometric analysis of caffeine interaction with novantrone, doxorubicin, ellipticine, and the doxorubicin analogue AD198.
Cancer research 1991;51(14):3682-9.
1991: Myc A; DeAngelis P; Lassota P; Melamed M R; Darzynkiewicz Z
Effect of swainsonine on interleukin-2 alpha chain receptor expression and proliferation of human lymphocytes.
Clinical and experimental immunology 1991;84(3):406-10.
1991: Traganos F; Kaminska-Eddy B; Darzynkiewicz Z
Caffeine reverses the cytotoxic and cell kinetic effects of Novantrone (mitoxantrone).
Cell proliferation 1991;24(3):305-19.
1991: Jakóbisiak M; Bruno S; Skierski J S; Darzynkiewicz Z
Cell cycle-specific effects of lovastatin.
Proceedings of the National Academy of Sciences of the United States of America 1991;88(9):3628-32.
1991: Lassota P; Melamed M R; Darzynkiewicz Z
Release of specific proteins from nuclei of HL-60 and MOLT-4 cells by antitumor drugs having affinity to nucleic acids.
Biochemical pharmacology 1991;41(6-7):1055-65.
1991: Del Bino G; Lassota P; Darzynkiewicz Z
The S-phase cytotoxicity of camptothecin.
Experimental cell research 1991;193(1):27-35.
1991: Del Bino G; Darzynkiewicz Z
Camptothecin, teniposide, or 4'-(9-acridinylamino)-3-methanesulfon-m-anisidide, but not mitoxantrone or doxorubicin, induces degradation of nuclear DNA in the S phase of HL-60 cells.
Cancer research 1991;51(4):1165-9.
1991: Myc A; DeAngelis P; Kimmel M; Melamed M R; Darzynkiewicz Z
Retention of the mitochondrial probe rhodamine 123 in normal lymphocytes and leukemic cells in relation to the cell cycle.
Experimental cell research 1991;192(1):198-202.
1990: Bretton P R; Darzynkiewicz Z; Henry E; Kimmel M; Fair W R; Melamed M R
DNA in situ sensitivity to denaturation in bladder cancer and its correlation with tumor stage.
Cancer research 1990;50(24):7912-4.
1990: Del Bino G; Skierski J S; Darzynkiewicz Z
Diverse effects of camptothecin, an inhibitor of topoisomerase I, on the cell cycle of lymphocytic (L1210, MOLT-4) and myelogenous (HL-60, KG1) leukemic cells.
Cancer research 1990;50(18):5746-50.
1990: Kunicka J E; Myc A; Melamed M R; Darzynkiewicz Z
Caffeine increases sensitivity of DNA to denaturation in chromatin of L1210 cells.
Cell and tissue kinetics 1990;23(1):31-9.
1990: Kapuscinski J; Darzynkiewicz Z
Spectral properties of fluorochromes used in flow cytometry.
Methods in cell biology 1990;33():655-69.
1990: Darzynkiewicz Z
Acid-induced denaturation of DNA in situ as a probe of chromatin structure.
Methods in cell biology 1990;33():337-52.
1990: Darzynkiewicz Z
Differential staining of DNA and RNA in intact cells and isolated cell nuclei with acridine orange.
Methods in cell biology 1990;33():285-98.
1989: Bories D; Raynal M C; Solomon D H; Darzynkiewicz Z; Cayre Y E
Down-regulation of a serine protease, myeloblastin, causes growth arrest and differentiation of promyelocytic leukemia cells.
Cell 1989;59(6):959-68.
1989: Kunicka J E; Olszewski W; Rosen P P; Kimmel M; Melamed M R; Darzynkiewicz Z
DNA in situ sensitivity to denaturation as a marker of human breast tumors.
Cancer research 1989;49(22):6347-51.
1989: Koyama M; Takahashi K; Chou T C; Darzynkiewicz Z; Kapuscinski J; Kelly T R; Watanabe K A
Intercalating agents with covalent bond forming capability. A novel type of potential anticancer agents. 2. Derivatives of chrysophanol and emodin.
Journal of medicinal chemistry 1989;32(7):1594-9.
1989: Traganos F; Bueti C; Kapuscinski J; Darzynkiewicz Z
The antitumor intercalating drug ditercalinium binds preferentially to RNA in Friend erythroleukemia cells.
Leukemia : official journal of the Leukemia Society of America, Leukemia Research Fund, U.K 1989;3(7):522-9.
1989: Myc A; Kunicka J E; Melamed M R; Darzynkiewicz Z
Effect of swainsonine on stimulation and cell cycle progression of human lymphocytes.
Cancer research 1989;49(11):2879-83.
1989: Darzynkiewicz Z; Carter S P
Thermal stability of nucleosomes studied in situ by flow cytometry: effect of ionic strength and n-butyrate.
Experimental cell research 1989;180(2):551-6.
1988: Darzynkiewicz Z
Flow cytometry in cytopathology. Overview and perspectives.
Analytical and quantitative cytology and histology / the International Academy of Cytology [and] American Society of Cytology 1988;10(6):459-61.
1988: Darzynkiewicz Z; Traganos F
Unstainable DNA in cell nuclei. Comparison of ten different fluorochromes.
Analytical and quantitative cytology and histology / the International Academy of Cytology [and] American Society of Cytology 1988;10(6):462-6.
1988: Darzynkiewicz Z
Cellular RNA content, a feature correlated with cell kinetics and tumor prognosis.
Leukemia : official journal of the Leukemia Society of America, Leukemia Research Fund, U.K 1988;2(12):777-87.
1988: Kapuscinski J; Traganos F; Darzynkiewicz Z
Interactions of antitumor drug ditercalinium with nucleic acids in solutions and in situ.
Cancer letters 1988;42(3):185-91.
1988: Darzynkiewicz Z; Carter S P; Mikulski S M; Ardelt W J; Shogen K
Cytostatic and cytotoxic effects of Pannon (P-30 Protein), a novel anticancer agent.
Cell and tissue kinetics 1988;21(3):169-82.
1988: Darzynkiewicz Z; Carter S P
Photosensitizing effects of the tricyclic heteroaromatic cationic dyes pyronin Y and toluidine blue O (tolonium chloride).
Cancer research 1988;48(5):1295-9.
1988: Darzynkiewicz Z; Kapuscinski J
Condensation of DNA in situ in metaphase chromosomes induced by intercalating ligands and its relationship to chromosome banding.
Cytometry 1988;9(1):7-18.
1987: Cayre Y; Raynal M C; Darzynkiewicz Z; Dorner M H
Model for intermediate steps in monocytic differentiation: c-myc, c-fms, and ferritin as markers.
Proceedings of the National Academy of Sciences of the United States of America 1987;84(21):7619-23.
1987: Traganos F; Kimmel M; Bueti C; Darzynkiewicz Z
Effects of inhibition of RNA or protein synthesis on CHO cell cycle progression.
Journal of cellular physiology 1987;133(2):277-87.
1987: Darzynkiewicz Z; Traganos F; Carter S P; Higgins P J
In situ factors affecting stability of the DNA helix in interphase nuclei and metaphase chromosomes.
Experimental cell research 1987;172(1):168-79.
1987: Traganos F; Bueti C; Melamed M R; Darzynkiewicz Z
Cytokinetic effects of bifunctional antitumor intercalator ditercalinium on Friend erythroleukemia cells.
Leukemia : official journal of the Leukemia Society of America, Leukemia Research Fund, U.K 1987;1(5):411-6.
1984: Kimmel M; Darzynkiewicz Z; Arino O; Traganos F
Analysis of a cell cycle model based on unequal division of metabolic constituents to daughter cells during cytokinesis.
Journal of theoretical biology 1984;110(4):637-64.
1984: Kapuscinski J; Darzynkiewicz Z
Denaturation of nucleic acids induced by intercalating agents. Biochemical and biophysical properties of acridine orange-DNA complexes.
Journal of biomolecular structure & dynamics 1984;1(6):1485-99.

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