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Frédéric Altare

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Florence Deknuydt; Antoine Roquilly; Frédéric Altare; Raphaël Cinotti; Karim Asehnoune
An in vitro model of mycobacterial granuloma to investigate the immune response in brain-injured patients.
Mayra Silva Miranda; Sophie Allain; Adrien Breiman; Florence Deknuydt; Frédéric Altare
The tuberculous granuloma: an unsuccessful host defence mechanism providing a safety shelter for the bacteria?
Nidia Alvarez-Rueda; Florence Deknuydt; Marjorie Albassier; Sophie Allain; Frédéric Altare; Patrice LE PAPE
First human model of in vitro Candida albicans persistence within granuloma for the reliable study of host-fungi interactions.

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All Publications

2013: Florence Deknuydt; Antoine Roquilly; Frédéric Altare; Raphaël Cinotti; Karim Asehnoune
An in vitro model of mycobacterial granuloma to investigate the immune response in brain-injured patients.
Critical care medicine 2013;41(1):245-54.
2012: Mayra Silva Miranda; Sophie Allain; Adrien Breiman; Florence Deknuydt; Frédéric Altare
The tuberculous granuloma: an unsuccessful host defence mechanism providing a safety shelter for the bacteria?
Clinical & developmental immunology 2012;2012():139127.
2012: Nidia Alvarez-Rueda; Florence Deknuydt; Marjorie Albassier; Sophie Allain; Frédéric Altare; Patrice LE PAPE
First human model of in vitro Candida albicans persistence within granuloma for the reliable study of host-fungi interactions.
PloS one 2012;7(6):e40185.
2009: David G Russell; Pere-Joan Cardona; Mi-Jeong Kim; Sophie Allain; Frédéric Altare
Foamy macrophages and the progression of the human tuberculosis granuloma.
Nature immunology 2009;10(9):943-8.
2009: Cécile Taflin; Makoto Miyara; Dominique Nochy; Dominique Valeyre; Jean-Marc Naccache; Frédéric Altare; Pascale Salek-Peyron; Cécile Badoual; Patrick Bruneval; Julien Haroche; Alexis Mathian; Zahir Amoura; GARY HILL; Guy Gorochov
FoxP3+ regulatory T cells suppress early stages of granuloma formation but have little impact on sarcoidosis lesions.
The American journal of pathology 2009;174(2):497-508.
2008: Pascale Peyron; Julien Vaubourgeix; Yannick Poquet; Florence Levillain; Catherine Botanch; Fabienne Bardou; Mamadou Daffé; Jean-François Emile; Bruno Marchou; Pere-Joan Cardona; Chantal de Chastellier; Frédéric Altare
Foamy macrophages from tuberculous patients' granulomas constitute a nutrient-rich reservoir for M. tuberculosis persistence.
PLoS pathogens 2008;4(11):e1000204.
2007: Sonia Meconi; Alain Vercellone; Florence Levillain; Bruno Payré; Talal Al Saati; Florence Capilla; Pierre Desreumaux; Arlette Darfeuille-Michaud; Frédéric Altare
Adherent-invasive Escherichia coli isolated from Crohn's disease patients induce granulomas in vitro.
Cellular microbiology 2007;9(5):1252-61.
2007: Marie-Pierre Puissegur; Guillaume Lay; Martine GILLERON; Laure Botella; Jerome Nigou; Hedia Marrakchi; Bernard Mari; Jean-Luc Duteyrat; Yann Guerardel; Laurent Kremer; Pascal Barbry; Germain Puzo; Frédéric Altare
Mycobacterial lipomannan induces granuloma macrophage fusion via a TLR2-dependent, ADAM9- and beta1 integrin-mediated pathway.
Journal of immunology (Baltimore, Md. : 1950) 2007;178(5):3161-9.
2007: G Lay; Y Poquet; P Salek-Peyron; Marie-Pierre Puissegur; C Botanch; H Bon; F Levillain; Jean-Luc Duteyrat; Jean-François Emile; Frédéric Altare
Langhans giant cells from M. tuberculosis-induced human granulomas cannot mediate mycobacterial uptake.
The Journal of pathology 2007;211(1):76-85.
2004: Marie-Pierre Puissegur; Catherine Botanch; Jean-Luc Duteyrat; Georges Delsol; Claude Caratero; Frédéric Altare
An in vitro dual model of mycobacterial granulomas to investigate the molecular interactions between mycobacteria and human host cells.
Cellular microbiology 2004;6(5):423-33.
2002: Giuliana Losana; Chiara Bovolenta; Laura Rigamonti; Igor Borghi; Frédéric Altare; Emmanuelle Jouanguy; Guido Forni; Jean-Laurent Casanova; Barbara Sherry; Manuela Mengozzi; Trinchieri Giorgio; Guido Poli; Franca Gerosa; Francesco Novelli
IFN-gamma and IL-12 differentially regulate CC-chemokine secretion and CCR5 expression in human T lymphocytes.
Journal of leukocyte biology 2002;72(4):735-42.
2002: Giuliana Losana; Laura Rigamonti; Igor Borghi; Barbara Assenzio; Silvia Ariotti; Emmanuelle Jouanguy; Frédéric Altare; Guido Forni; Jean-Laurent Casanova; Francesco Novelli
Requirement for both IL-12 and IFN-gamma signaling pathways in optimal IFN-gamma production by human T cells.
European journal of immunology 2002;32(3):693-700.
2002: Capucine Picard; Claire Fieschi; Frédéric Altare; Sulaiman Al-Jumaah; Sami Al-Hajjar; Jacqueline Feinberg; Stéphanie Dupuis; Claire Soudais; Ibrahim Zaid Al-Mohsen; Emmanuelle Génin; David A Lammas; Dinakantha S Kumararatne; Tony Leclerc; Arash Rafii; Husn H Frayha; Belinda Murugasu; Lee Bee Wah; Raja Sinniah; Michael Loubser; Emi Okamoto; Abdulaziz Al-Ghonaium; Haysam Tufenkeji; Laurent Abel; Jean-Laurent Casanova
Inherited interleukin-12 deficiency: IL12B genotype and clinical phenotype of 13 patients from six kindreds.
American journal of human genetics 2002;70(2):336-48.
2001: Frédéric Altare; A Ensser; Adrien Breiman; Janine Reichenbach; J E Baghdadi; Alain Fischer; Jean-François Emile; Jean-Louis Gaillard; E Meinl; Jean-Laurent Casanova
Interleukin-12 receptor beta1 deficiency in a patient with abdominal tuberculosis.
The Journal of infectious diseases 2001;184(2):231-6.
2000: Stéphanie Dupuis; Rainer Döffinger; Capucine Picard; Claire Fieschi; Frédéric Altare; Emmanuelle Jouanguy; Laurent Abel; Jean-Laurent Casanova
Human interferon-gamma-mediated immunity is a genetically controlled continuous trait that determines the outcome of mycobacterial invasion.
Immunological reviews 2000;178():129-37.
2000: Rainer Döffinger; Frédéric Altare; Jean-Laurent Casanova
Genetic heterogeneity of Mendelian susceptibility to mycobacterial infection.
Microbes and infection / Institut Pasteur 2000;2(13):1553-7.
2000: Jared A Gollob; Korina G Veenstra; H Jyonouchi; Anne Kelly; P Ferrieri; David J Panka; Frédéric Altare; Claire Fieschi; J L Casanova; David A Frank; James W Mier
Impairment of STAT activation by IL-12 in a patient with atypical mycobacterial and staphylococcal infections.
Journal of immunology (Baltimore, Md. : 1950) 2000;165(7):4120-6.
2000: Emmanuelle Jouanguy; Stéphanie Dupuis; Annaïck Pallier; Rainer Döffinger; Marie-Claude Fondanèche; Claire Fieschi; S Lamhamedi-Cherradi; Frédéric Altare; Jean-François Emile; P Lutz; P Bordigoni; Haluk Cokugras; Necla Akcakaya; J Landman-Parker; J Donnadieu; Yildiz Camcioglu; Jean-Laurent Casanova
In a novel form of IFN-gamma receptor 1 deficiency, cell surface receptors fail to bind IFN-gamma.
The Journal of clinical investigation 2000;105(10):1429-36.
2000: Rainer Döffinger; Emmanuelle Jouanguy; Stéphanie Dupuis; Marie-Claude Fondanèche; Jean Louis Stephan; Jean-François Emile; S Lamhamedi-Cherradi; Frédéric Altare; Annaïck Pallier; Gabriela Barcenas-Morales; E Meinl; C Krause; S Pestka; Robert D Schreiber; Francesco Novelli; Jean-Laurent Casanova
Partial interferon-gamma receptor signaling chain deficiency in a patient with bacille Calmette-Guérin and Mycobacterium abscessus infection.
The Journal of infectious diseases 2000;181(1):379-84.
1999: Emmanuelle Jouanguy; Rainer Döffinger; Stéphanie Dupuis; Annaïck Pallier; Frédéric Altare; Jean-Laurent Casanova
IL-12 and IFN-gamma in host defense against mycobacteria and salmonella in mice and men.
Current opinion in immunology 1999;11(3):346-51.
1999: Rainer Döffinger; Emmanuelle Jouanguy; Frédéric Altare; P Wood; T Shirakawa; Francesco Novelli; David A Lammas; Dinakantha S Kumararatne; J L Casanova
Inheritable defects in interleukin-12- and interferon-gamma-mediated immunity and the TH1/TH2 paradigm in man.
Allergy 1999;54(5):409-12.
1999: Emmanuelle Jouanguy; S Lamhamedi-Cherradi; David A Lammas; Susan E Dorman; Marie-Claude Fondanèche; Stéphanie Dupuis; Rainer Döffinger; Frédéric Altare; John Girdlestone; Jean-François Emile; H Ducoulombier; D Edgar; J Clarke; V A Oxelius; M Brai; V Novelli; Klaus Heyne; Alain Fischer; Steven M Holland; Dinakantha S Kumararatne; Robert D Schreiber; Jean-Laurent Casanova
A human IFNGR1 small deletion hotspot associated with dominant susceptibility to mycobacterial infection.
Nature genetics 1999;21(4):370-8.
1998: Frédéric Altare; David A Lammas; Patrick Revy; Emmanuelle Jouanguy; Rainer Döffinger; S Lamhamedi; Pam Drysdale; Dagmar Scheel-Toellner; John Girdlestone; P Darbyshire; M Wadhwa; H Dockrell; Mike Salmon; Alain Fischer; Anne Durandy; Jean-Laurent Casanova; Dinakantha S Kumararatne
Inherited interleukin 12 deficiency in a child with bacille Calmette-Guérin and Salmonella enteritidis disseminated infection.
The Journal of clinical investigation 1998;102(12):2035-40.
1998: Frédéric Altare; Emmanuelle Jouanguy; S Lamhamedi; Rainer Döffinger; Alain Fischer; Jean-Laurent Casanova
Mendelian susceptibility to mycobacterial infection in man.
Current opinion in immunology 1998;10(4):413-7.
1998: Frédéric Altare; Anne Durandy; David A Lammas; Jean-François Emile; S Lamhamedi; Françoise Le Deist; Pam Drysdale; Emmanuelle Jouanguy; Rainer Döffinger; Françoise Bernaudin; O Jeppsson; Jared A Gollob; E Meinl; A W Segal; Alain Fischer; Dinakantha S Kumararatne; Jean-Laurent Casanova
Impairment of mycobacterial immunity in human interleukin-12 receptor deficiency.
Science (New York, N.Y.) 1998;280(5368):1432-5.
1998: Frédéric Altare; Emmanuelle Jouanguy; S Lamhamedi-Cherradi; M C Fondanéche; C Fizame; F Ribiérre; G Merlin; Z Dembic; R Schreiber; Barbara Lisowska-Grospierre; Alain Fischer; E Seboun; Jean-Laurent Casanova
A causative relationship between mutant IFNgR1 alleles and impaired cellular response to IFNgamma in a compound heterozygous child.
American journal of human genetics 1998;62(3):723-6.
1998: S Lamhamedi; Emmanuelle Jouanguy; Frédéric Altare; Joachim Roesler; Jean-Laurent Casanova
Interferon-gamma receptor deficiency: relationship between genotype, environment, and phenotype (Review).
International journal of molecular medicine 1998;1(2):415-8.
1997: Emmanuelle Jouanguy; S Lamhamedi-Cherradi; Frédéric Altare; Marie-Claude Fondanèche; D Tuerlinckx; Stéphane Blanche; Jean-François Emile; Jean-Louis Gaillard; R Schreiber; M Levin; Alain Fischer; Claire Hivroz; Jean-Laurent Casanova
Partial interferon-gamma receptor 1 deficiency in a child with tuberculoid bacillus Calmette-Guérin infection and a sibling with clinical tuberculosis.
The Journal of clinical investigation 1997;100(11):2658-64.
1997: Emmanuelle Jouanguy; Frédéric Altare; S Lamhamedi-Cherradi; Jean-Laurent Casanova
Infections in IFNGR-1-deficient children.
Journal of interferon & cytokine research : the official journal of the International Society for Interferon and Cytokine Research 1997;17(10):583-7.
1997: Catherine Pierre-Audigier; Emmanuelle Jouanguy; S Lamhamedi; Frédéric Altare; J Rauzier; Véronique Vincent; D Canioni; Jean-François Emile; Alain Fischer; Stéphane Blanche; Jean-Louis Gaillard; Jean-Laurent Casanova
Fatal disseminated Mycobacterium smegmatis infection in a child with inherited interferon gamma receptor deficiency.
Clinical infectious diseases : an official publication of the Infectious Diseases Society of America 1997;24(5):982-4.
1997: Jean-François Emile; Natacha Patey; Frédéric Altare; S Lamhamedi; Emmanuelle Jouanguy; Françoise Boman; J Quillard; M Lecomte-Houcke; Olivier Verola; J F Mousnier; Frédérique Dijoud; Stéphane Blanche; Alain Fischer; Nicole Brousse; Jean-Laurent Casanova
Correlation of granuloma structure with clinical outcome defines two types of idiopathic disseminated BCG infection.
The Journal of pathology 1997;181(1):25-30.
1996: Emmanuelle Jouanguy; Frédéric Altare; S Lamhamedi; Patrick Revy; Jean-François Emile; M Newport; M Levin; Stéphane Blanche; E Seboun; Alain Fischer; Jean-Laurent Casanova
Interferon-gamma-receptor deficiency in an infant with fatal bacille Calmette-Guérin infection.
The New England journal of medicine 1996;335(26):1956-61.
1996: Jean-Laurent Casanova; Stéphane Blanche; Jean-François Emile; Emmanuelle Jouanguy; S Lamhamedi; Frédéric Altare; Jean-Louis Stéphan; Françoise Bernaudin; P Bordigoni; D Turck; A Lachaux; M Albertini; A Bourrillon; J P Dommergues; M A Pocidalo; Françoise Le Deist; Jean-Louis Gaillard; C Griscelli; Alain Fischer
Idiopathic disseminated bacillus Calmette-Guérin infection: a French national retrospective study.
Pediatrics 1996;98(4 Pt 1):774-8.