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Roderick Dashwood

This is a preview profile on BiomedExperts - the first literature-based scientific social network. It brings the right researchers together and allows them to collaborate online. Collexis and Dell provide the BiomedExperts network of +1.5 Million pre-calculated profiles free of charge to researchers worldwide.

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Chemicals & Drugs

Disorders

Colonic Neoplasms

Living Beings

Objects

Tea
Diet

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Mutagenicity Tests

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Co-Publications
Name
32
Bailey, George
17
Dashwood, Wan-Mohaiza
17
Hendricks, Jerry
17
Xu, Meirong
16
Williams, David
15
Orner, Gayle
13
Li, Qingjie
9
Myzak, Melinda
9
Ho, Emily
6
Fischer, Kay
6
Löhr, Christiane
6
Blum, Carmen
6
Pereira, Cliff
5
Santana-Rios, Gilberto
5
Al-Fageeh, Mohamed

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Publications

TOP 3
Larsen Christine A; Bisson William H; Dashwood Roderick H
Tea catechins inhibit hepatocyte growth factor receptor (MET Kinase) activity in human colon cancer cells: kinetic and molecular docking studies.
Larsen Christine A; Dashwood Roderick H
Suppression of Met activation in human colon cancer cells treated with (-)-epigallocatechin-3-gallate: minor role of hydrogen peroxide.
Chimploy Korakod; Díaz G Dario; Li Qingjie; Carter Orianna; Dashwood Wan-Mohaiza; Mathews Christopher K; Williams David E; Bailey George S; Dashwood Roderick H
E2F4 and ribonucleotide reductase mediate S-phase arrest in colon cancer cells treated with chlorophyllin.

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All Publications

2009: Larsen Christine A; Bisson William H; Dashwood Roderick H
Tea catechins inhibit hepatocyte growth factor receptor (MET Kinase) activity in human colon cancer cells: kinetic and molecular docking studies.
Journal of medicinal chemistry 2009;52(21):6543-5.
2009: Larsen Christine A; Dashwood Roderick H
Suppression of Met activation in human colon cancer cells treated with (-)-epigallocatechin-3-gallate: minor role of hydrogen peroxide.
Biochemical and biophysical research communications 2009;389(3):527-30.
2009: Chimploy Korakod; Díaz G Dario; Li Qingjie; Carter Orianna; Dashwood Wan-Mohaiza; Mathews Christopher K; Williams David E; Bailey George S; Dashwood Roderick H
E2F4 and ribonucleotide reductase mediate S-phase arrest in colon cancer cells treated with chlorophyllin.
International journal of cancer. Journal international du cancer 2009;125(9):2086-94.
2009: Li Qingjie; Löhr Christiane V; Dashwood Roderick H
Activator protein 2alpha suppresses intestinal tumorigenesis in the Apc(min) mouse.
Cancer letters 2009;283(1):36-42.
2009: Nian Hui; Bisson William H; Dashwood Wan-Mohaiza; Pinto John T; Dashwood Roderick H
Alpha-keto acid metabolites of organoselenium compounds inhibit histone deacetylase activity in human colon cancer cells.
Carcinogenesis 2009;30(8):1416-23.
2009: Lee Jeong-In; Nian Hui; Cooper Arthur J L; Sinha Raghu; Dai Jenny; Bisson William H; Dashwood Roderick H; Pinto John T
Alpha-keto acid metabolites of naturally occurring organoselenium compounds as inhibitors of histone deacetylase in human prostate cancer cells.
Cancer prevention research (Philadelphia, Pa.) 2009;2(7):683-93.
2009: Nian Hui; Delage Barbara; Ho Emily; Dashwood Roderick H
Modulation of histone deacetylase activity by dietary isothiocyanates and allyl sulfides: studies with sulforaphane and garlic organosulfur compounds.
Environmental and molecular mutagenesis 2009;50(3):213-21.
2009: Hasaniya Nahidh W; Premaratne Shyamal; Zhang Wayne W; Razzuk Aziz M; Abdul-Ghani Ayman A; Siera Milea; Dashwood Roderick H; Eklof Bo; Tinsley Larry R; McNamara J Judson
Ischemia-reperfusion injury in the lung: quantitation using electron microscopy.
Vascular and endovascular surgery 2009;43(2):170-7.
2009: Castro David J; Löhr Christiane V; Fischer Kay A; Waters Katrina M; Webb-Robertson Bobbie-Jo M; Dashwood Roderick H; Bailey George S; Williams David E
Identifying efficacious approaches to chemoprevention with chlorophyllin, purified chlorophylls and freeze-dried spinach in a mouse model of transplacental carcinogenesis.
Carcinogenesis 2009;30(2):315-20.
2008: Clarke John D; Dashwood Roderick H; Ho Emily
Multi-targeted prevention of cancer by sulforaphane.
Cancer letters 2008;269(2):291-304.
2008: Nian Hui; Delage Barbara; Pinto John T; Dashwood Roderick H
Allyl mercaptan, a garlic-derived organosulfur compound, inhibits histone deacetylase and enhances Sp3 binding on the P21WAF1 promoter.
Carcinogenesis 2008;29(9):1816-24.
2008: Wang Rong; Dashwood W Mohaiza; Löhr Christiane V; Fischer Kay A; Nakagama Hitoshi; Williams David E; Dashwood Roderick H
beta-catenin is strongly elevated in rat colonic epithelium following short-term intermittent treatment with 2-amino-1-methyl-6-phenylimidazo[4,5-b]pyridine (PhIP) and a high-fat diet.
Cancer science 2008;99(9):1754-9.
2008: Dashwood Roderick H; Ho Emily
Dietary agents as histone deacetylase inhibitors: sulforaphane and structurally related isothiocyanates.
Nutrition reviews 2008;66 Suppl 1():S36-8.
2008: Castro David J; Yu Zhen; Löhr Christiane V; Pereira Clifford B; Giovanini Jack N; Fischer Kay A; Orner Gayle A; Dashwood Roderick H; Williams David E
Chemoprevention of dibenzo[a,l]pyrene transplacental carcinogenesis in mice born to mothers administered green tea: primary role of caffeine.
Carcinogenesis 2008;29(8):1581-6.
2008: Wang Rong; Dashwood W Mohaiza; Löhr Christiane V; Fischer Kay A; Pereira Clifford B; Louderback Mandy; Nakagama Hitoshi; Bailey George S; Williams David E; Dashwood Roderick H
Protective versus promotional effects of white tea and caffeine on PhIP-induced tumorigenesis and beta-catenin expression in the rat.
Carcinogenesis 2008;29(4):834-9.
2008: Simonich Michael T; McQuistan Tammie; Jubert Carole; Pereira Cliff; Hendricks Jerry D; Schimerlik Michael; Zhu Benzan; Dashwood Roderick H; Williams David E; Bailey George S
Low-dose dietary chlorophyll inhibits multi-organ carcinogenesis in the rainbow trout.
Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association 2008;46(3):1014-24.
2008: Delage Barbara; Dashwood Roderick H
Dietary manipulation of histone structure and function.
Annual review of nutrition 2008;28():347-66.
2007: Dashwood Roderick H; Ho Emily
Dietary histone deacetylase inhibitors: from cells to mice to man.
Seminars in cancer biology 2007;17(5):363-9.
2007: Li Q; Dashwood W M; Zhong X; Nakagama H; Dashwood R H
Bcl-2 overexpression in PhIP-induced colon tumors: cloning of the rat Bcl-2 promoter and characterization of a pathway involving beta-catenin, c-Myc and E2F1.
Oncogene 2007;26(42):6194-202.
2007: Simonich Michael T; Egner Patricia A; Roebuck Bill D; Orner Gayle A; Jubert Carole; Pereira Cliff; Groopman John D; Kensler Thomas W; Dashwood Roderick H; Williams David E; Bailey George S
Natural chlorophyll inhibits aflatoxin B1-induced multi-organ carcinogenesis in the rat.
Carcinogenesis 2007;28(6):1294-302.
2007: Higdon Jane V; Delage Barbara; Williams David E; Dashwood Roderick H
Cruciferous vegetables and human cancer risk: epidemiologic evidence and mechanistic basis.
Pharmacological research : the official journal of the Italian Pharmacological Society 2007;55(3):224-36.
2007: Myzak Melinda C; Tong Philip; Dashwood Wan-Mohaiza; Dashwood Roderick H; Ho Emily
Sulforaphane retards the growth of human PC-3 xenografts and inhibits HDAC activity in human subjects.
Experimental biology and medicine (Maywood, N.J.) 2007;232(2):227-34.
2007: Dashwood Roderick H
Frontiers in polyphenols and cancer prevention.
The Journal of nutrition 2007;137(1 Suppl):267S-269S.
2007: Carter Orianna; Dashwood Roderick H; Wang Rong; Dashwood W Mohaiza; Orner Gayle A; Fischer Kay A; Löhr Christiane V; Pereira Clifford B; Bailey George S; Williams David E
Comparison of white tea, green tea, epigallocatechin-3-gallate, and caffeine as inhibitors of PhIP-induced colonic aberrant crypts.
Nutrition and cancer 2007;58(1):60-5.
2006: Dashwood Roderick H
Xenobiotic metabolism relevance to cancer.
The Journal of nutrition 2006;136(10):2681S-2S.
2006: Wang Rong; Dashwood W Mohaiza; Bailey George S; Williams David E; Dashwood Roderick H
Tumors from rats given 1,2-dimethylhydrazine plus chlorophyllin or indole-3-carbinol contain transcriptional changes in beta-catenin that are independent of beta-catenin mutation status.
Mutation research 2006;601(1-2):11-8.
2006: Myzak Melinda C; Ho Emily; Dashwood Roderick H
Dietary agents as histone deacetylase inhibitors.
Molecular carcinogenesis 2006;45(6):443-6.
2006: Cope R B; Loehr C; Dashwood R; Kerkvliet N I
Ultraviolet radiation-induced non-melanoma skin cancer in the Crl:SKH1:hr-BR hairless mouse: augmentation of tumor multiplicity by chlorophyllin and protection by indole-3-carbinol.
Photochemical & photobiological sciences : Official journal of the European Photochemistry Association and the European Society for Photobiology 2006;5(5):499-507.
2006: Myzak Melinda C; Dashwood Roderick H
Histone deacetylases as targets for dietary cancer preventive agents: lessons learned with butyrate, diallyl disulfide, and sulforaphane.
Current drug targets 2006;7(4):443-52.
2006: Myzak Melinda C; Hardin Karin; Wang Rong; Dashwood Roderick H; Ho Emily
Sulforaphane inhibits histone deacetylase activity in BPH-1, LnCaP and PC-3 prostate epithelial cells.
Carcinogenesis 2006;27(4):811-9.
2006: Myzak Melinda C; Dashwood W Mohaiza; Orner Gayle A; Ho Emily; Dashwood Roderick H
Sulforaphane inhibits histone deacetylase in vivo and suppresses tumorigenesis in Apc-minus mice.
The FASEB journal : official publication of the Federation of American Societies for Experimental Biology 2006;20(3):506-8.
2006: Myzak Melinda C; Dashwood Roderick H
Chemoprotection by sulforaphane: keep one eye beyond Keap1.
Cancer letters 2006;233(2):208-18.
2006: Dashwood Roderick H; Myzak Melinda C; Ho Emily
Dietary HDAC inhibitors: time to rethink weak ligands in cancer chemoprevention?
Carcinogenesis 2006;27(2):344-9.
2006: Yu Zhen; Loehr Christiane V; Fischer Kay A; Louderback Mandy A; Krueger Sharon K; Dashwood Roderick H; Kerkvliet Nancy I; Pereira Clifford B; Jennings-Gee Jamie E; Dance Stephanie T; Miller Mark Steven; Bailey George S; Williams David E
In utero exposure of mice to dibenzo[a,l]pyrene produces lymphoma in the offspring: role of the aryl hydrocarbon receptor.
Cancer research 2006;66(2):755-62.
2006: Kwon Daejoong; Yoon Sun; Carter Orianna; Bailey George S; Dashwood Roderick H
Antioxidant and antigenotoxic activities of Angelica keiskei, Oenanthe javanica and Brassica oleracea in the Salmonella mutagenicity assay and in HCT116 human colon cancer cells.
BioFactors (Oxford, England) 2006;26(4):231-44.
2006: Orner Gayle A; Roebuck Bill D; Dashwood Roderick H; Bailey George S
Post-initiation chlorophyllin exposure does not modulate aflatoxin-induced foci in the liver and colon of rats.
Journal of carcinogenesis 2006;5():6.
2005: Dashwood Wan-Mohaiza; Carter Orianna; Al-Fageeh Mohamed; Li Qingjie; Dashwood Roderick H
Lysosomal trafficking of beta-catenin induced by the tea polyphenol epigallocatechin-3-gallate.
Mutation research 2005;591(1-2):161-72.
2004: Carter Orianna; Bailey George S; Dashwood Roderick H
The dietary phytochemical chlorophyllin alters E-cadherin and beta-catenin expression in human colon cancer cells.
The Journal of nutrition 2004;134(12 Suppl):3441S-3444S.
2004: Orner Gayle A; Dashwood Wan-Mohaiza; Dashwood Roderick H
Tumor-suppressing effects of antioxidants from tea.
The Journal of nutrition 2004;134(11):3177S-3178S.
2004: Li Qingjie; Dashwood Roderick H
Activator protein 2alpha associates with adenomatous polyposis coli/beta-catenin and Inhibits beta-catenin/T-cell factor transcriptional activity in colorectal cancer cells.
The Journal of biological chemistry 2004;279(44):45669-75.
2004: Myzak Melinda C; Karplus P Andrew; Chung Fung-Lung; Dashwood Roderick H
A novel mechanism of chemoprotection by sulforaphane: inhibition of histone deacetylase.
Cancer research 2004;64(16):5767-74.
2004: Al-Fageeh Mohamed; Li Qingjie; Dashwood W Mohaiza; Myzak Melinda C; Dashwood Roderick H
Phosphorylation and ubiquitination of oncogenic mutants of beta-catenin containing substitutions at Asp32.
Oncogene 2004;23(28):4839-46.
2004: Mastaloudis Angela; Yu Tian-Wei; O'Donnell Robert P; Frei Balz; Dashwood Roderick H; Traber Maret G
Endurance exercise results in DNA damage as detected by the comet assay.
Free radical biology & medicine 2004;36(8):966-75.
2004: Li Qingjie; Dashwood Wan-Mohaiza; Zhong Xiaoying; Al-Fageeh Mohamed; Dashwood Roderick H
Cloning of the rat beta-catenin gene (Ctnnb1) promoter and its functional analysis compared with the Catnb and CTNNB1 promoters.
Genomics 2004;83(2):231-42.
2004: Yu Tian-Wei; Xu Meirong; Dashwood Roderick H
Antimutagenic activity of spearmint.
Environmental and molecular mutagenesis 2004;44(5):387-93.
2003: Dashwood R H; Xu M
The disposition and metabolism of 2-amino-3-methylimidazo-[4,5-f]quinoline in the F344 rat at high versus low doses of indole-3-carbinol.
Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association 2003;41(8):1185-92.
2003: Blum Carmen A; Tanaka Tomoko; Zhong Xiaoying; Li Qingjie; Dashwood Wan-Mohaiza; Pereira Clifford; Xu Meirong; Dashwood Roderick H
Mutational analysis of Ctnnb1 and Apc in tumors from rats given 1,2-dimethylhydrazine or 2-amino-3-methylimidazo[4,5-f]quinoline: mutational 'hotspots' and the relative expression of beta-catenin and c-jun.
Molecular carcinogenesis 2003;36(4):195-203.
2003: Díaz G Darío; Li Qingjie; Dashwood Roderick H
Caspase-8 and apoptosis-inducing factor mediate a cytochrome c-independent pathway of apoptosis in human colon cancer cells induced by the dietary phytochemical chlorophyllin.
Cancer research 2003;63(6):1254-61.
2003: Blum Carmen A; Xu Meirong; Orner Gayle A; Darío Díaz G; Li Qingjie; Dashwood Wan Mohaiza; Bailey George S; Dashwood Roderick H
Promotion versus suppression of rat colon carcinogenesis by chlorophyllin and chlorophyll: modulation of apoptosis, cell proliferation, and beta-catenin/Tcf signaling.
Mutation research 2003;523-524():217-23.
2003: Orner Gayle A; Dashwood W-Mohaiza; Blum Carmen A; Díaz G Darío; Li Qingjie; Dashwood Roderick H
Suppression of tumorigenesis in the Apc(min) mouse: down-regulation of beta-catenin signaling by a combination of tea plus sulindac.
Carcinogenesis 2003;24(2):263-7.
2003: Dashwood Roderick H
Use of transgenic and mutant animal models in the study of heterocyclic amine-induced mutagenesis and carcinogenesis.
Journal of biochemistry and molecular biology 2003;36(1):35-42.
2002: Orner Gayle A; Dashwood Wan-Mohaiza; Blum Carmen A; Díaz G Darío; Li Qingjie; Al-Fageeh Mohamad; Tebbutt Niall; Heath Joan K; Ernst Matthias; Dashwood Roderick H
Response of Apc(min) and A33 (delta N beta-cat) mutant mice to treatment with tea, sulindac, and 2-amino-1-methyl-6-phenylimidazo[4,5-b]pyridine (PhIP).
Mutation research 2002;506-507():121-7.
2002: Dashwood Wan-Mohaiza; Orner Gayle A; Dashwood Roderick H
Inhibition of beta-catenin/Tcf activity by white tea, green tea, and epigallocatechin-3-gallate (EGCG): minor contribution of H(2)O(2) at physiologically relevant EGCG concentrations.
Biochemical and biophysical research communications 2002;296(3):584-8.
2002: Dashwood Roderick H
Modulation of heterocyclic amine-induced mutagenicity and carcinogenicity: an 'A-to-Z' guide to chemopreventive agents, promoters, and transgenic models.
Mutation research 2002;511(2):89-112.
2002: Amantana Adams; Santana-Rios Gilberto; Butler Judith A; Xu Meirong; Whanger Phil D; Dashwood Roderick H
Antimutagenic activity of selenium-enriched green tea toward the heterocyclic amine 2-amino-3-methylimidazo[4,5-f]quinoline.
Biological trace element research 2002;86(2):177-91.
2002: Li Qingjie; Dixon Brian M; Al-Fageeh Mohamed; Blum Carmen A; Dashwood Roderick H
Sequencing of the rat beta-catenin gene (Ctnnb1) and mutational analysis of liver tumors induced by 2-amino-3-methylimidazo[4,5-f]quinoline.
Gene 2002;283(1-2):255-62.
2002: Franke Adrian A; Custer Laurie J; Cooney Robert V; Tanaka Yuichiro; Xu Meirong; Dashwood Roderick H
Inhibition of colonic aberrant crypt formation by the dietary flavonoids (+)-catechin and hesperidin.
Advances in experimental medicine and biology 2002;505():123-33.
2001: Santana-Rios G; Orner G A; Amantana A; Provost C; Wu S Y; Dashwood R H
Potent antimutagenic activity of white tea in comparison with green tea in the Salmonella assay.
Mutation research 2001;495(1-2):61-74.
2001: Yu Z; Xu M; Santana-Rios G; Shen R; Izquierdo-Pulido M; Williams D E; Dashwood R H
A comparison of whole wheat, refined wheat and wheat bran as inhibitors of heterocyclic amines in the Salmonella mutagenicity assay and in the rat colonic aberrant crypt focus assay.
Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association 2001;39(7):655-65.
2001: Dashwood R H; Xu M; Orner G A; Horio D T
Colonic cell proliferation, apoptosis and aberrant crypt foci development in rats given 2-amino-3-methylimidaz.
European journal of cancer prevention : the official journal of the European Cancer Prevention Organisation (ECP) 2001;10(2):139-45.
2001: Blum C A; Xu M; Orner G A; Fong A T; Bailey G S; Stoner G D; Horio D T; Dashwood R H
beta-Catenin mutation in rat colon tumors initiated by 1,2-dimethylhydrazine and 2-amino-3-methylimidazo[4,5-f]quinoline, and the effect of post-initiation treatment with chlorophyllin and indole-3-carbinol.
Carcinogenesis 2001;22(2):315-20.
2001: Xu M; Orner G A; Bailey G S; Stoner G D; Horio D T; Dashwood R H
Post-initiation effects of chlorophyllin and indole-3-carbinol in rats given 1,2-dimethylhydrazine or 2-amino-3-methyl- imidazo.
Carcinogenesis 2001;22(2):309-14.
2001: Santana-Rios G; Orner G A; Xu M; Izquierdo-Pulido M; Dashwood R H
Inhibition by white tea of 2-amino-1-methyl-6-phenylimidazo[4,5-b]pyridine-induced colonic aberrant crypts in the F344 rat.
Nutrition and cancer 2001;41(1-2):98-103.
1999: Xu M; Chen R; Dashwood R H
Effect of carcinogen dose fractionation, diet and source of F344 rat on the induction of colonic aberrant crypts by 2-amino-3-methylimidazo[4,5-f]quinoline.
Carcinogenesis 1999;20(12):2293-8.
1999: Santana-Rios G; Dashwood R H
Time to discontinue antigenotoxicity studies of dietary fiber?
Mutation research 1999;429(2):269-71.
1999: Xu M; Dashwood R H
Chemoprevention studies of heterocyclic amine-induced colon carcinogenesis.
Cancer letters 1999;143(2):179-83.
1999: Breinholt V; Arbogast D; Loveland P; Pereira C; Dashwood R; Hendricks J; Bailey G
Chlorophyllin chemoprevention in trout initiated by aflatoxin B(1) bath treatment: An evaluation of reduced bioavailability vs. target organ protective mechanisms.
Toxicology and applied pharmacology 1999;158(2):141-51.
1999: Dashwood R H; Xu M; Hernaez J F; Hasaniya N; Youn K; Razzuk A
Cancer chemopreventive mechanisms of tea against heterocyclic amine mutagens from cooked meat.
Proceedings of the Society for Experimental Biology and Medicine. Society for Experimental Biology and Medicine (New York, N.Y.) 1999;220(4):239-43.
1999: Dashwood R H
Early detection and prevention of colorectal cancer (review).
Oncology reports 1999;6(2):277-81.
1998: Hernaez J F; Xu M; Dashwood R H
Antimutagenic activity of tea towards 2-hydroxyamino-3-methylimidazo[4,5-f]quinoline: effect of tea concentration and brew time on electrophile scavenging.
Mutation research 1998;402(1-2):299-306.
1998: Dashwood R; Negishi T; Hayatsu H; Breinholt V; Hendricks J; Bailey G
Chemopreventive properties of chlorophylls towards aflatoxin B1: a review of the antimutagenicity and anticarcinogenicity data in rainbow trout.
Mutation research 1998;399(2):245-53.
1998: Bailey G S; Dashwood R; Loveland P M; Pereira C; Hendricks J D
Molecular dosimetry in fish: quantitative target organ DNA adduction and hepatocarcinogenicity for four aflatoxins by two exposure routes in rainbow trout.
Mutation research 1998;399(2):233-44.
1998: Dashwood R H
Indole-3-carbinol: anticarcinogen or tumor promoter in brassica vegetables?
Chemico-biological interactions 1998;110(1-2):1-5.
1997: Dashwood R H
The importance of using pure chemicals in (anti) mutagenicity studies: chlorophyllin as a case in point.
Mutation research 1997;381(2):283-6.
1997: Xu M; Schut H A; Bjeldanes L F; Williams D E; Bailey G S; Dashwood R H
Inhibition of 2-amino-3-methylimidazo[4,5-f]quinoline-DNA adducts by indole-3-carbinol: dose-response studies in the rat colon.
Carcinogenesis 1997;18(11):2149-53.
1997: Hasaniya N; Youn K; Xu M; Hernaez J; Dashwood R
Inhibitory activity of green and black tea in a free radical-generating system using 2-amino-3-methylimidazo[4,5-f]quinoline as substrate.
Japanese journal of cancer research : Gann 1997;88(6):553-8.
1997: Hernaez J; Xu M; Dashwood R
Effects of tea and chlorophyllin on the mutagenicity of N-hydroxy-IQ: studies of enzyme inhibition, molecular complex formation, and degradation/scavenging of the active metabolites.
Environmental and molecular mutagenesis 1997;30(4):468-74.
1996: Hayashi R; Luk H; Horio D; Dashwood R
Inhibition of apoptosis in colon tumors induced in the rat by 2-amino-3-methylimidazo[4,5-f]quinoline.
Cancer research 1996;56(19):4307-10.
1996: Xu M; Bailey A C; Hernaez J F; Taoka C R; Schut H A; Dashwood R H
Protection by green tea, black tea, and indole-3-carbinol against 2-amino-3-methylimidazo[4,5-f]quinoline-induced DNA adducts and colonic aberrant crypts in the F344 rat.
Carcinogenesis 1996;17(7):1429-34.
1996: Dashwood R; Yamane S; Larsen R
Study of the forces of stabilizing complexes between chlorophylls and heterocyclic amine mutagens.
Environmental and molecular mutagenesis 1996;27(3):211-8.
1995: Liew C; Schut H A; Chin S F; Pariza M W; Dashwood R H
Protection of conjugated linoleic acids against 2-amino-3- methylimidazo[4,5-f]quinoline-induced colon carcinogenesis in the F344 rat: a study of inhibitory mechanisms.
Carcinogenesis 1995;16(12):3037-43.
1995: Guo D; Schut H A; Davis C D; Snyderwine E G; Bailey G S; Dashwood R H
Protection by chlorophyllin and indole-3-carbinol against 2-amino-1-methyl-6-phenylimidazo[4,5-b]pyridine (PhIP)-induced DNA adducts and colonic aberrant crypts in the F344 rat.
Carcinogenesis 1995;16(12):2931-7.
1995: Takahashi N; Dashwood R H; Bjeldanes L F; Williams D E; Bailey G S
Mechanisms of indole-3-carbinol (I3C) anticarcinogenesis: inhibition of aflatoxin B1-DNA adduction and mutagenesis by I3C acid condensation products.
Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association 1995;33(10):851-7.
1995: Guo D; Horio D T; Grove J S; Dashwood R H
Inhibition by chlorophyllin of 2-amino-3-methylimidazo-[4,5-f]quinoline-induced tumorigenesis in the male F344 rat.
Cancer letters 1995;95(1-2):161-5.
1995: Breinholt V; Schimerlik M; Dashwood R; Bailey G
Mechanisms of chlorophyllin anticarcinogenesis against aflatoxin B1: complex formation with the carcinogen.
Chemical research in toxicology 1995;8(4):506-14.
1995: Tachino N; Hayashi R; Liew C; Bailey G; Dashwood R
Evidence for ras gene mutation in 2-amino-3-methylimidazo[4,5-f]quinoline-induced colonic aberrant crypts in the rat.
Molecular carcinogenesis 1995;12(4):187-92.
1995: Takahashi N; Dashwood R H; Bjeldanes L F; Bailey G S; Williams D E
Regulation of hepatic cytochrome P4501A by indole-3-carbinol: transient induction with continuous feeding in rainbow trout.
Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association 1995;33(2):111-20.
1995: Dashwood R; Guo D
Protective properties of chlorophylls against the covalent binding of heterocyclic amines to DNA in vitro and in vivo.
Princess Takamatsu symposia 1995;23():181-9.
1994: Dashwood R H; Fong A T; Arbogast D N; Bjeldanes L F; Hendricks J D; Bailey G S
Anticarcinogenic activity of indole-3-carbinol acid products: ultrasensitive bioassay by trout embryo microinjection.
Cancer research 1994;54(13):3617-9.
1994: Tachino N; Guo D; Dashwood W M; Yamane S; Larsen R; Dashwood R
Mechanisms of the in vitro antimutagenic action of chlorophyllin against benzo[a]pyrene: studies of enzyme inhibition, molecular complex formation and degradation of the ultimate carcinogen.
Mutation research 1994;308(2):191-203.
1994: Guo D; Dashwood R
Inhibition of 2-amino-3-methylimidazo[4,5-f]quinoline (IQ)-DNA binding in rats given chlorophyllin: dose-response and time-course studies in the liver and colon.
Carcinogenesis 1994;15(4):763-6.
1993: Fong A T; Dashwood R H; Cheng R; Mathews C; Ford B; Hendricks J D; Bailey G S
Carcinogenicity, metabolism and Ki-ras proto-oncogene activation by 7,12-dimethylbenz[a]anthracene in rainbow trout embryos.
Carcinogenesis 1993;14(4):629-35.
1993: Dashwood R; Guo D
Antimutagenic potency of chlorophyllin in the Salmonella assay and its correlation with binding constants of mutagen-inhibitor complexes.
Environmental and molecular mutagenesis 1993;22(3):164-71.
1992: Dashwood R; Guo D
Inhibition of 2-amino-3-methylimidazo[4,5-f]quinoline (IQ)-DNA binding by chlorophyllin: studies of enzyme inhibition and molecular complex formation.
Carcinogenesis 1992;13(7):1121-6.
1992: Bailey G; Hendricks J; Dashwood R
Anticarcinogenesis in fish.
Mutation research 1992;267(2):243-50.
1992: Dashwood R H
Protection by chlorophyllin against the covalent binding of 2-amino-3-methylimidazo[4,5-f]quinoline (IQ) to rat liver DNA.
Carcinogenesis 1992;13(1):113-8.
1992: Dashwood R; Liew C
Chlorophyllin-enhanced excretion of urinary and fecal mutagens in rats given 2-amino-3-methylimidazo[4,5-f]quinoline.
Environmental and molecular mutagenesis 1992;20(3):199-205.
1991: Dashwood R H; Breinholt V; Bailey G S
Chemopreventive properties of chlorophyllin: inhibition of aflatoxin B1 (AFB1)-DNA binding in vivo and anti-mutagenic activity against AFB1 and two heterocyclic amines in the Salmonella mutagenicity assay.
Carcinogenesis 1991;12(5):939-42.
1991: Dashwood R H; Fong A T; Williams D E; Hendricks J D; Bailey G S
Promotion of aflatoxin B1 carcinogenesis by the natural tumor modulator indole-3-carbinol: influence of dose, duration, and intermittent exposure on indole-3-carbinol promotional potency.
Cancer research 1991;51(9):2362-5.
1991: Bailey G S; Dashwood R H; Fong A T; Williams D E; Scanlan R A; Hendricks J D
Modulation of mycotoxin and nitrosamine carcinogenesis by indole-3-carbinol: quantitative analysis of inhibition versus promotion.
IARC scientific publications 1991;(105):275-80.
1990: Fong A T; Swanson H I; Dashwood R H; Williams D E; Hendricks J D; Bailey G S
Mechanisms of anti-carcinogenesis by indole-3-carbinol. Studies of enzyme induction, electrophile-scavenging, and inhibition of aflatoxin B1 activation.
Biochemical pharmacology 1990;39(1):19-26.
1990: Dashwood R H; Loveland P M; Fong A T; Hendricks J D; Bailey G S
Combined in vivo DNA binding and tumor dose-response studies to investigate the molecular dosimetry concept.
Progress in clinical and biological research 1990;340D():335-44.
1990: Dashwood R H; Fong A T; Hendricks J D; Bailey G S
Tumor dose-response studies with aflatoxin B1 and the ambivalent modulator indole-3-carbinol: inhibitory versus promotional potency.
Basic life sciences 1990;52():361-5.
1989: Dashwood R H; Uyetake L; Fong A T; Hendricks J D; Bailey G S
In vivo disposition of the natural anti-carcinogen indole-3-carbinol after po administration to rainbow trout.
Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association 1989;27(6):385-92.
1989: Dashwood R H; Arbogast D N; Fong A T; Pereira C; Hendricks J D; Bailey G S
Quantitative inter-relationships between aflatoxin B1 carcinogen dose, indole-3-carbinol anti-carcinogen dose, target organ DNA adduction and final tumor response.
Carcinogenesis 1989;10(1):175-81.
1988: Fong A T; Hendricks J D; Dashwood R H; Van Winkle S; Lee B C; Bailey G S
Modulation of diethylnitrosamine-induced hepatocarcinogenesis and O6-ethylguanine formation in rainbow trout by indole-3-carbinol, beta-naphthoflavone, and Aroclor 1254.
Toxicology and applied pharmacology 1988;96(1):93-100.
1988: Fong A T; Hendricks J D; Dashwood R H; Van Winkle S; Bailey G S
Formation and persistence of ethylguanines in liver DNA of rainbow trout (Salmo gairdneri) treated with diethylnitrosamine by water exposure.
Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association 1988;26(8):699-704.
1988: Dashwood R H; Arbogast D N; Fong A T; Hendricks J D; Bailey G S
Mechanisms of anti-carcinogenesis by indole-3-carbinol: detailed in vivo DNA binding dose-response studies after dietary administration with aflatoxin B1.
Carcinogenesis 1988;9(3):427-32.

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