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Roderick Dashwood

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Lyndsey E Shorey; Lauren L Atwell; Roderick H Dashwood; Emily Ho; Christiane V Löhr; Erin P Madeen; Clifford B Pereira; David E Williams
Differential modulation of dibenzo[def,p]chrysene transplacental carcinogenesis: Maternal diets rich in indole-3-carbinol versus sulforaphane.
Rong Wang; David E Williams; Hassan Ashktorab; Michael R Dashwood; Wan-Mohaiza Dashwood; Kay Fischer; Jeffrey A Greenwood; Emily Ho; Christiane V Löhr; Roderick H Dashwood
Epigenetic inactivation of endothelin-2 and endothelin-3 in colon cancer.
Laura M Beaver; Roderick H Dashwood; Elizabeth I Sokolowski; David E Williams; Tian-Wei Yu; Emily Ho
3,3'-Diindolylmethane, but not indole-3-carbinol, inhibits histone deacetylase activity in prostate cancer cells.

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2013: Lyndsey E Shorey; Lauren L Atwell; Roderick H Dashwood; Emily Ho; Christiane V Löhr; Erin P Madeen; Clifford B Pereira; David E Williams
Differential modulation of dibenzo[def,p]chrysene transplacental carcinogenesis: Maternal diets rich in indole-3-carbinol versus sulforaphane.
Toxicology and applied pharmacology 2013;270(1):60-9.
2013: Rong Wang; David E Williams; Hassan Ashktorab; Michael R Dashwood; Wan-Mohaiza Dashwood; Kay Fischer; Jeffrey A Greenwood; Emily Ho; Christiane V Löhr; Roderick H Dashwood
Epigenetic inactivation of endothelin-2 and endothelin-3 in colon cancer.
International journal of cancer. Journal international du cancer 2013;132(5):1004-12.
2012: Laura M Beaver; Roderick H Dashwood; Elizabeth I Sokolowski; David E Williams; Tian-Wei Yu; Emily Ho
3,3'-Diindolylmethane, but not indole-3-carbinol, inhibits histone deacetylase activity in prostate cancer cells.
Toxicology and applied pharmacology 2012;263(3):345-51.
2012: Mansi A Parasramka; Rong Wang; David E Williams; Amir Abdelli; George S Bailey; W Mohaiza Dashwood; Emily Ho; Roderick H Dashwood
MicroRNA profiling of carcinogen-induced rat colon tumors and the influence of dietary spinach.
Molecular nutrition & food research 2012;56(8):1259-69.
2012: Seong-Ho Lee; Raphael L Richardson; Roderick H Dashwood; Seung Joon Baek
Capsaicin represses transcriptional activity of β-catenin in human colorectal cancer cells.
The Journal of nutritional biochemistry 2012;23(6):646-55.
2012: Tammie J McQuistan; Cliff B Pereira; M Margaret Pratt; Michael T Simonich; David E Williams; Roderick H Dashwood; Jerry D Hendricks; George S Bailey
Cancer chemoprevention by dietary chlorophylls: a 12,000-animal dose-dose matrix biomarker and tumor study.
Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association 2012;50(2):341-52.
2012: Mansi A Parasramka; Hassaan H Saeed; Rong Wang; David E Williams; W Mohaiza Dashwood; Emily Ho; Roderick H Dashwood
A role for low-abundance miRNAs in colon cancer: the miR-206/Krüppel-like factor 4 (KLF4) axis.
Clinical epigenetics 2012;4(1):16.
2012: Lyndsey E Shorey; David E Williams; Roderick H Dashwood; Amanda M Hagman; Emily Ho; Abby D Benninghoff
3,3'-Diindolylmethane induces G1 arrest and apoptosis in human acute T-cell lymphoblastic leukemia cells.
PloS one 2012;7(4):e34975.
2011: John D Clarke; Roderick H Dashwood; Anna Hsu; Jan F Stevens; David E Williams; Masayuki Yamamoto; Emily Ho
Metabolism and tissue distribution of sulforaphane in Nrf2 knockout and wild-type mice.
Pharmaceutical research 2011;28(12):3171-9.
2011: Emily Ho; David E Williams; Laura M Beaver; Roderick H Dashwood
Dietary factors and epigenetic regulation for prostate cancer prevention.
Advances in nutrition (Bethesda, Md.) 2011;2(6):497-510.
2011: NW Hasaniya; Ayman A Abdul-Ghani; Roderick H Dashwood; Bo Eklof; Shyamal Premaratne; AM Razzuk; Larry Tinsley; Wayne W Zhang; J Judson McNamara
Amelioration of ischemia-reperfusion injury in an isolated rabbit lung model using OXANOH.
Vascular and endovascular surgery 2011;45(7):581-91.
2011: Wentao Wang; Xuejun Wang; Tian-Wei Yu; Wei Zhang; Roderick H Dashwood; Narumol Jariyasopit; Yuling Jia; Jill Schrlau; Shu Tao; Staci L Massey Simonich
Concentration and photochemistry of PAHs, NPAHs, and OPAHs and toxicity of PM2.5 during the Beijing Olympic Games.
Environmental science & technology 2011;45(16):6887-95.
2011: Qingjie Li; Christiane V Löhr; Cunhui Luo; Roderick H Dashwood
Activator protein-2α functions as a master regulator of multiple transcription factors in the mouse liver.
Hepatology research : the official journal of the Japan Society of Hepatology 2011;41(8):776-83.
2011: Young-Joon Surh; Hye-Kyung Na; Roderick H Dashwood; Li Li Ji
Introduction to Nutrition and physical activity in aging, obesity, and cancer.
Annals of the New York Academy of Sciences 2011;1229():vii-viii.
2011: John D Clarke; Roderick H Dashwood; Anna Hsu; Zhen Yu; Emily Ho
Differential effects of sulforaphane on histone deacetylases, cell cycle arrest and apoptosis in normal prostate cells versus hyperplastic and cancerous prostate cells.
Molecular nutrition & food research 2011;55(7):999-1009.
2011: Praveen Rajendran; David E Williams; Emily Ho; Roderick H Dashwood
Metabolism as a key to histone deacetylase inhibition.
Critical reviews in biochemistry and molecular biology 2011;46(3):181-99.
2011: Rong Wang; Roderick H Dashwood
Endothelins and their receptors in cancer: identification of therapeutic targets.
Pharmacological research : the official journal of the Italian Pharmacological Society 2011;63(6):519-24.
2011: Rong Wang; Wan-Mohaiza Dashwood; Hui Nian; Christiane V Löhr; Kay A Fischer; Naoto Tsuchiya; Hitoshi Nakagama; Hassan Ashktorab; Roderick H Dashwood
NADPH oxidase overexpression in human colon cancers and rat colon tumors induced by 2-amino-1-methyl-6-phenylimidazo[4,5-b]pyridine (PhIP).
International journal of cancer. Journal international du cancer 2011;128(11):2581-90.
2011: Anna Hsu; David E Williams; Carmen P Wong; Zhen Yu; Roderick H Dashwood; Emily Ho
Promoter de-methylation of cyclin D2 by sulforaphane in prostate cancer cells.
Clinical epigenetics 2011;3():3.
2011: Praveen Rajendran; David E Williams; Emily Ho; Roderick H Dashwood
Dietary phytochemicals, HDAC inhibition, and DNA damage/repair defects in cancer cells.
Clinical epigenetics 2011;3(1):4.
2011: Praveen Rajendran; David E Williams; Bradyn Wuth; Tian-Wei Yu; W Mohaiza Dashwood; Barbara Delage; Emily Ho; Roderick H Dashwood
Histone deacetylase turnover and recovery in sulforaphane-treated colon cancer cells: competing actions of 14-3-3 and Pin1 in HDAC3/SMRT corepressor complex dissociation/reassembly.
Molecular cancer 2011;10():68.
2010: Christine A Larsen; Roderick H Dashwood; William H Bisson
Tea catechins as inhibitors of receptor tyrosine kinases: mechanistic insights and human relevance.
Pharmacological research : the official journal of the Italian Pharmacological Society 2010;62(6):457-64.
2010: Christine A Larsen; Roderick H Dashwood
(-)-Epigallocatechin-3-gallate inhibits Met signaling, proliferation, and invasiveness in human colon cancer cells.
Archives of biochemistry and biophysics 2010;501(1):52-7.
2010: I-K Kwon; R Wang; Muthusamy Thangaraju; H Shuang; Kebin Liu; Roderick H Dashwood; Nickolai O Dulin; Vadivel Ganapathy; Darren Browning
PKG inhibits TCF signaling in colon cancer cells by blocking beta-catenin expression and activating FOXO4.
Oncogene 2010;29(23):3423-34.
2010: Emily Ho; Roderick H Dashwood
Dietary manipulation of histone structure and function.
Journal of nutrigenetics and nutrigenomics 2010;3(4-6):231-8.
2010: Emily Ho; Roderick H Dashwood
Dietary manipulation of histone structure and function.
World review of nutrition and dietetics 2010;101():95-102.
2009: Carole Jubert; John Mata; Graham Bench; Roderick H Dashwood; Cliff Pereira; William Tracewell; Kenneth Turteltaub; David Williams; George Bailey
Effects of chlorophyll and chlorophyllin on low-dose aflatoxin B(1) pharmacokinetics in human volunteers.
Cancer prevention research (Philadelphia, Pa.) 2009;2(12):1015-22.
2009: Emily Ho; John D Clarke; Roderick H Dashwood
Dietary sulforaphane, a histone deacetylase inhibitor for cancer prevention.
The Journal of nutrition 2009;139(12):2393-6.
2009: Christine A Larsen; Roderick H Dashwood
Suppression of Met activation in human colon cancer cells treated with (-)-epigallocatechin-3-gallate: minor role of hydrogen peroxide.
Biochemical and biophysical research communications 2009;389(3):527-30.
2009: Christine A Larsen; William H Bisson; Roderick H Dashwood
Tea catechins inhibit hepatocyte growth factor receptor (MET kinase) activity in human colon cancer cells: kinetic and molecular docking studies.
Journal of medicinal chemistry 2009;52(21):6543-5.
2009: Korakod Chimploy; G Dario Díaz; Qingjie Li; Orianna Carter; Wan-Mohaiza Dashwood; Christopher K Mathews; David E Williams; George S Bailey; Roderick H Dashwood
E2F4 and ribonucleotide reductase mediate S-phase arrest in colon cancer cells treated with chlorophyllin.
International journal of cancer. Journal international du cancer 2009;125(9):2086-94.
2009: Qingjie Li; Christiane V Löhr; Roderick H Dashwood
Activator protein 2alpha suppresses intestinal tumorigenesis in the Apc(min) mouse.
Cancer letters 2009;283(1):36-42.
2009: Hui Nian; William H Bisson; Wan-Mohaiza Dashwood; John Pinto; Roderick H Dashwood
Alpha-keto acid metabolites of organoselenium compounds inhibit histone deacetylase activity in human colon cancer cells.
Carcinogenesis 2009;30(8):1416-23.
2009: Jeong-In Lee; Hui Nian; Arthur J L Cooper; Raghu Sinha; Jenny Dai; William H Bisson; Roderick H Dashwood; John Pinto
Alpha-keto acid metabolites of naturally occurring organoselenium compounds as inhibitors of histone deacetylase in human prostate cancer cells.
Cancer prevention research (Philadelphia, Pa.) 2009;2(7):683-93.
2009: Hui Nian; Barbara Delage; Emily Ho; Roderick H Dashwood
Modulation of histone deacetylase activity by dietary isothiocyanates and allyl sulfides: studies with sulforaphane and garlic organosulfur compounds.
Environmental and molecular mutagenesis 2009;50(3):213-21.
2009: Nahidh W Hasaniya; Shyamal Premaratne; Wayne W Zhang; Aziz M Razzuk; Ayman A Abdul-Ghani; Milea Siera; Roderick H Dashwood; Bo Eklof; Larry R Tinsley; J Judson McNamara
Ischemia-reperfusion injury in the lung: quantitation using electron microscopy.
Vascular and endovascular surgery 2009;43(2):170-7.
2009: David J Castro; Christiane V Löhr; Kay A Fischer; Katrina M Waters; Bobbie-Jo M Webb-Robertson; Roderick H Dashwood; George S Bailey; David E Williams
Identifying efficacious approaches to chemoprevention with chlorophyllin, purified chlorophylls and freeze-dried spinach in a mouse model of transplacental carcinogenesis.
Carcinogenesis 2009;30(2):315-20.
2008: John D Clarke; Roderick H Dashwood; Emily Ho
Multi-targeted prevention of cancer by sulforaphane.
Cancer letters 2008;269(2):291-304.
2008: Hui Nian; Barbara Delage; John Pinto; Roderick H Dashwood
Allyl mercaptan, a garlic-derived organosulfur compound, inhibits histone deacetylase and enhances Sp3 binding on the P21WAF1 promoter.
Carcinogenesis 2008;29(9):1816-24.
2008: Rong Wang; W Mohaiza Dashwood; Christiane V Löhr; Kay A Fischer; Hitoshi Nakagama; David E Williams; Roderick H Dashwood
beta-catenin is strongly elevated in rat colonic epithelium following short-term intermittent treatment with 2-amino-1-methyl-6-phenylimidazo[4,5-b]pyridine (PhIP) and a high-fat diet.
Cancer science 2008;99(9):1754-9.
2008: Roderick H Dashwood; Emily Ho
Dietary agents as histone deacetylase inhibitors: sulforaphane and structurally related isothiocyanates.
Nutrition reviews 2008;66 Suppl 1():S36-8.
2008: David J Castro; Zhen Yu; Christiane V Löhr; Clifford B Pereira; Jack N Giovanini; Kay A Fischer; Gayle A Orner; Roderick H Dashwood; David E Williams
Chemoprevention of dibenzo[a,l]pyrene transplacental carcinogenesis in mice born to mothers administered green tea: primary role of caffeine.
Carcinogenesis 2008;29(8):1581-6.
2008: Rong Wang; Wan-Mohaiza Dashwood; Christiane V Löhr; Kay A Fischer; Clifford B Pereira; Mandy Louderback; Hitoshi Nakagama; George S Bailey; David E Williams; Roderick H Dashwood
Protective versus promotional effects of white tea and caffeine on PhIP-induced tumorigenesis and beta-catenin expression in the rat.
Carcinogenesis 2008;29(4):834-9.
2008: Michael T Simonich; Tammie McQuistan; Carole Jubert; Cliff Pereira; Jerry D Hendricks; Michael I Schimerlik; Benzan Zhu; Roderick H Dashwood; David E Williams; George S Bailey
Low-dose dietary chlorophyll inhibits multi-organ carcinogenesis in the rainbow trout.
Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association 2008;46(3):1014-24.
2008: Barbara Delage; Roderick H Dashwood
Dietary manipulation of histone structure and function.
Annual review of nutrition 2008;28():347-66.
2007: Roderick H Dashwood; Emily Ho
Dietary histone deacetylase inhibitors: from cells to mice to man.
Seminars in cancer biology 2007;17(5):363-9.
2007: Qingjie Li; Wan-Mohaiza Dashwood; Xiaoying Zhong; H Nakagama; Roderick H Dashwood
Bcl-2 overexpression in PhIP-induced colon tumors: cloning of the rat Bcl-2 promoter and characterization of a pathway involving beta-catenin, c-Myc and E2F1.
Oncogene 2007;26(42):6194-202.
2007: Michael T Simonich; Patricia A Egner; Bill D Roebuck; Gayle A Orner; Carole Jubert; Cliff Pereira; John Groopman; Thomas W Kensler; Roderick H Dashwood; David E Williams; George S Bailey
Natural chlorophyll inhibits aflatoxin B1-induced multi-organ carcinogenesis in the rat.
Carcinogenesis 2007;28(6):1294-302.
2007: Jane V Higdon; Barbara Delage; David E Williams; Roderick H Dashwood
Cruciferous vegetables and human cancer risk: epidemiologic evidence and mechanistic basis.
Pharmacological research : the official journal of the Italian Pharmacological Society 2007;55(3):224-36.
2007: Melinda C Myzak; Philip Tong; Wan-Mohaiza Dashwood; Roderick H Dashwood; Emily Ho
Sulforaphane retards the growth of human PC-3 xenografts and inhibits HDAC activity in human subjects.
Experimental biology and medicine (Maywood, N.J.) 2007;232(2):227-34.
2007: Orianna Carter; Roderick H Dashwood; Rong Wang; Wan-Mohaiza Dashwood; Gayle A Orner; Kay A Fischer; Christiane V Löhr; Clifford B Pereira; George S Bailey; David E Williams
Comparison of white tea, green tea, epigallocatechin-3-gallate, and caffeine as inhibitors of PhIP-induced colonic aberrant crypts.
Nutrition and cancer 2007;58(1):60-5.
2007: Roderick H Dashwood
Frontiers in polyphenols and cancer prevention.
The Journal of nutrition 2007;137(1 Suppl):267S-269S.
2006: Rong Wang; Wan-Mohaiza Dashwood; George S Bailey; David E Williams; Roderick H Dashwood
Tumors from rats given 1,2-dimethylhydrazine plus chlorophyllin or indole-3-carbinol contain transcriptional changes in beta-catenin that are independent of beta-catenin mutation status.
Mutation research 2006;601(1-2):11-8.
2006: Roderick H Dashwood
Xenobiotic metabolism relevance to cancer.
The Journal of nutrition 2006;136(10):2681S-2S.
2006: Melinda C Myzak; Emily Ho; Roderick H Dashwood
Dietary agents as histone deacetylase inhibitors.
Molecular carcinogenesis 2006;45(6):443-6.
2006: Rhian Cope; C Loehr; Roderick H Dashwood; Nancy Kerkvliet
Ultraviolet radiation-induced non-melanoma skin cancer in the Crl:SKH1:hr-BR hairless mouse: augmentation of tumor multiplicity by chlorophyllin and protection by indole-3-carbinol.
Photochemical & photobiological sciences : Official journal of the European Photochemistry Association and the European Society for Photobiology 2006;5(5):499-507.
2006: Melinda C Myzak; Roderick H Dashwood
Histone deacetylases as targets for dietary cancer preventive agents: lessons learned with butyrate, diallyl disulfide, and sulforaphane.
Current drug targets 2006;7(4):443-52.
2006: Melinda C Myzak; Karin Hardin; Rong Wang; Roderick H Dashwood; Emily Ho
Sulforaphane inhibits histone deacetylase activity in BPH-1, LnCaP and PC-3 prostate epithelial cells.
Carcinogenesis 2006;27(4):811-9.
2006: Melinda C Myzak; Wan-Mohaiza Dashwood; Gayle A Orner; Emily Ho; Roderick H Dashwood
Sulforaphane inhibits histone deacetylase in vivo and suppresses tumorigenesis in Apc-minus mice.
FASEB journal : official publication of the Federation of American Societies for Experimental Biology 2006;20(3):506-8.
2006: Melinda C Myzak; Roderick H Dashwood
Chemoprotection by sulforaphane: keep one eye beyond Keap1.
Cancer letters 2006;233(2):208-18.
2006: Roderick H Dashwood; Melinda C Myzak; Emily Ho
Dietary HDAC inhibitors: time to rethink weak ligands in cancer chemoprevention?
Carcinogenesis 2006;27(2):344-9.
2006: Zhen Yu; Christiane V Loehr; Kay A Fischer; Mandy A Louderback; Sharon K Krueger; Roderick H Dashwood; Nancy Kerkvliet; Clifford B Pereira; Jamie E Jennings-Gee; Stephanie T Dance; Mark Steven Miller; George S Bailey; David E Williams
In utero exposure of mice to dibenzo[a,l]pyrene produces lymphoma in the offspring: role of the aryl hydrocarbon receptor.
Cancer research 2006;66(2):755-62.
2006: Daejoong Kwon; Sun Yoon; Orianna Carter; George S Bailey; Roderick H Dashwood
Antioxidant and antigenotoxic activities of Angelica keiskei, Oenanthe javanica and Brassica oleracea in the Salmonella mutagenicity assay and in HCT116 human colon cancer cells.
BioFactors (Oxford, England) 2006;26(4):231-44.
2006: Gayle A Orner; Bill D Roebuck; Roderick H Dashwood; George S Bailey
Post-initiation chlorophyllin exposure does not modulate aflatoxin-induced foci in the liver and colon of rats.
Journal of carcinogenesis 2006;5():6.
2005: Wan-Mohaiza Dashwood; Orianna Carter; Mohamed Al-Fageeh; Qingjie Li; Roderick H Dashwood
Lysosomal trafficking of beta-catenin induced by the tea polyphenol epigallocatechin-3-gallate.
Mutation research 2005;591(1-2):161-72.
2004: Orianna Carter; George S Bailey; Roderick H Dashwood
The dietary phytochemical chlorophyllin alters E-cadherin and beta-catenin expression in human colon cancer cells.
The Journal of nutrition 2004;134(12 Suppl):3441S-3444S.
2004: Gayle A Orner; Wan-Mohaiza Dashwood; Roderick H Dashwood
Tumor-suppressing effects of antioxidants from tea.
The Journal of nutrition 2004;134(11):3177S-3178S.
2004: Qingjie Li; Roderick H Dashwood
Activator protein 2alpha associates with adenomatous polyposis coli/beta-catenin and Inhibits beta-catenin/T-cell factor transcriptional activity in colorectal cancer cells.
The Journal of biological chemistry 2004;279(44):45669-75.
2004: Melinda C Myzak; P Andrew Karplus; Fung-Lung Chung; Roderick H Dashwood
A novel mechanism of chemoprotection by sulforaphane: inhibition of histone deacetylase.
Cancer research 2004;64(16):5767-74.
2004: Mohamed Al-Fageeh; Qingjie Li; Wan-Mohaiza Dashwood; Melinda C Myzak; Roderick H Dashwood
Phosphorylation and ubiquitination of oncogenic mutants of beta-catenin containing substitutions at Asp32.
Oncogene 2004;23(28):4839-46.
2004: Angela Mastaloudis; Tian-Wei Yu; Robert P O'Donnell; Balz Frei; Roderick H Dashwood; Maret G Traber
Endurance exercise results in DNA damage as detected by the comet assay.
Free radical biology & medicine 2004;36(8):966-75.
2004: Qingjie Li; Wan-Mohaiza Dashwood; Xiaoying Zhong; Mohamed Al-Fageeh; Roderick H Dashwood
Cloning of the rat beta-catenin gene (Ctnnb1) promoter and its functional analysis compared with the Catnb and CTNNB1 promoters.
Genomics 2004;83(2):231-42.
2004: Tian-Wei Yu; Meirong Xu; Roderick H Dashwood
Antimutagenic activity of spearmint.
Environmental and molecular mutagenesis 2004;44(5):387-93.
2003: Roderick H Dashwood; Meirong Xu
The disposition and metabolism of 2-amino-3-methylimidazo-[4,5-f]quinoline in the F344 rat at high versus low doses of indole-3-carbinol.
Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association 2003;41(8):1185-92.
2003: Carmen A Blum; Tomoko Tanaka; Xiaoying Zhong; Qingjie Li; Wan-Mohaiza Dashwood; Cliff Pereira; Meirong Xu; Roderick H Dashwood
Mutational analysis of Ctnnb1 and Apc in tumors from rats given 1,2-dimethylhydrazine or 2-amino-3-methylimidazo[4,5-f]quinoline: mutational 'hotspots' and the relative expression of beta-catenin and c-jun.
Molecular carcinogenesis 2003;36(4):195-203.
2003: G Darío Díaz; Qingjie Li; Roderick H Dashwood
Caspase-8 and apoptosis-inducing factor mediate a cytochrome c-independent pathway of apoptosis in human colon cancer cells induced by the dietary phytochemical chlorophyllin.
Cancer research 2003;63(6):1254-61.
2003: Carmen A Blum; Meirong Xu; Gayle A Orner; G Darío Díaz; Qingjie Li; Wan-Mohaiza Dashwood; George S Bailey; Roderick H Dashwood
Promotion versus suppression of rat colon carcinogenesis by chlorophyllin and chlorophyll: modulation of apoptosis, cell proliferation, and beta-catenin/Tcf signaling.
Mutation research 2003;523-524():217-23.
2003: Gayle A Orner; Wan-Mohaiza Dashwood; Carmen A Blum; G Darío Díaz; Qingjie Li; Roderick H Dashwood
Suppression of tumorigenesis in the Apc(min) mouse: down-regulation of beta-catenin signaling by a combination of tea plus sulindac.
Carcinogenesis 2003;24(2):263-7.
2003: Roderick H Dashwood
Use of transgenic and mutant animal models in the study of heterocyclic amine-induced mutagenesis and carcinogenesis.
Journal of biochemistry and molecular biology 2003;36(1):35-42.
2002: Gayle A Orner; Wan-Mohaiza Dashwood; Carmen A Blum; G Darío Díaz; Qingjie Li; Mohamed Al-Fageeh; Niall Tebbutt; Joan K Heath; Matthias Ernst; Roderick H Dashwood
Response of Apc(min) and A33 (delta N beta-cat) mutant mice to treatment with tea, sulindac, and 2-amino-1-methyl-6-phenylimidazo[4,5-b]pyridine (PhIP).
Mutation research 2002;506-507():121-7.
2002: Wan-Mohaiza Dashwood; Gayle A Orner; Roderick H Dashwood
Inhibition of beta-catenin/Tcf activity by white tea, green tea, and epigallocatechin-3-gallate (EGCG): minor contribution of H(2)O(2) at physiologically relevant EGCG concentrations.
Biochemical and biophysical research communications 2002;296(3):584-8.
2002: Roderick H Dashwood
Modulation of heterocyclic amine-induced mutagenicity and carcinogenicity: an 'A-to-Z' guide to chemopreventive agents, promoters, and transgenic models.
Mutation research 2002;511(2):89-112.
2002: Adams Amantana; Gilberto Santana-Rios; Judy A Butler; Meirong Xu; Philip D Whanger; Roderick H Dashwood
Antimutagenic activity of selenium-enriched green tea toward the heterocyclic amine 2-amino-3-methylimidazo[4,5-f]quinoline.
Biological trace element research 2002;86(2):177-91.
2002: Qingjie Li; Brian M Dixon; Mohamed Al-Fageeh; Carmen A Blum; Roderick H Dashwood
Sequencing of the rat beta-catenin gene (Ctnnb1) and mutational analysis of liver tumors induced by 2-amino-3-methylimidazo[4,5-f]quinoline.
Gene 2002;283(1-2):255-62.
2002: Adrian Franke; Laurie J Custer; Robert V Cooney; Yuichiro Tanaka; Meirong Xu; Roderick H Dashwood
Inhibition of colonic aberrant crypt formation by the dietary flavonoids (+)-catechin and hesperidin.
Advances in experimental medicine and biology 2002;505():123-33.
2001: Gilberto Santana-Rios; Gayle A Orner; Adams Amantana; C Provost; S Y Wu; Roderick H Dashwood
Potent antimutagenic activity of white tea in comparison with green tea in the Salmonella assay.
Mutation research 2001;495(1-2):61-74.
2001: Z Yu; Meirong Xu; Gilberto Santana-Rios; R Shen; M Izquierdo-Pulido; D E Williams; Roderick H Dashwood
A comparison of whole wheat, refined wheat and wheat bran as inhibitors of heterocyclic amines in the Salmonella mutagenicity assay and in the rat colonic aberrant crypt focus assay.
Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association 2001;39(7):655-65.
2001: Roderick H Dashwood; Meirong Xu; Gayle A Orner; DT Horio
Colonic cell proliferation, apoptosis and aberrant crypt foci development in rats given 2-amino-3-methylimidaz.
European journal of cancer prevention : the official journal of the European Cancer Prevention Organisation (ECP) 2001;10(2):139-45.
2001: Carmen A Blum; Meirong Xu; Gayle A Orner; A T Fong; George S Bailey; G D Stoner; DT Horio; Roderick H Dashwood
beta-Catenin mutation in rat colon tumors initiated by 1,2-dimethylhydrazine and 2-amino-3-methylimidazo[4,5-f]quinoline, and the effect of post-initiation treatment with chlorophyllin and indole-3-carbinol.
Carcinogenesis 2001;22(2):315-20.
2001: Meirong Xu; Gayle A Orner; George S Bailey; G D Stoner; DT Horio; Roderick H Dashwood
Post-initiation effects of chlorophyllin and indole-3-carbinol in rats given 1,2-dimethylhydrazine or 2-amino-3-methyl- imidazo.
Carcinogenesis 2001;22(2):309-14.
2001: Gilberto Santana-Rios; Gayle A Orner; Meirong Xu; M Izquierdo-Pulido; Roderick H Dashwood
Inhibition by white tea of 2-amino-1-methyl-6-phenylimidazo[4,5-b]pyridine-induced colonic aberrant crypts in the F344 rat.
Nutrition and cancer 2001;41(1-2):98-103.
1999: Meirong Xu; R Chen; Roderick H Dashwood
Effect of carcinogen dose fractionation, diet and source of F344 rat on the induction of colonic aberrant crypts by 2-amino-3-methylimidazo[4,5-f]quinoline.
Carcinogenesis 1999;20(12):2293-8.
1999: Gilberto Santana-Rios; Roderick H Dashwood
Time to discontinue antigenotoxicity studies of dietary fiber?
Mutation research 1999;429(2):269-71.
1999: Meirong Xu; Roderick H Dashwood
Chemoprevention studies of heterocyclic amine-induced colon carcinogenesis.
Cancer letters 1999;143(2):179-83.
1999: V Breinholt; D Arbogast; PM Loveland; Cliff Pereira; Roderick H Dashwood; Jerry D Hendricks; George Bailey
Chlorophyllin chemoprevention in trout initiated by aflatoxin B(1) bath treatment: An evaluation of reduced bioavailability vs. target organ protective mechanisms.
Toxicology and applied pharmacology 1999;158(2):141-51.
1999: Roderick H Dashwood; Meirong Xu; JF Hernaez; NW Hasaniya; K Youn; A Razzuk
Cancer chemopreventive mechanisms of tea against heterocyclic amine mutagens from cooked meat.
Proceedings of the Society for Experimental Biology and Medicine. Society for Experimental Biology and Medicine (New York, N.Y.) 1999;220(4):239-43.
1999: Roderick H Dashwood
Early detection and prevention of colorectal cancer (review).
Oncology reports 1999;6(2):277-81.
1998: JF Hernaez; Meirong Xu; Roderick H Dashwood
Antimutagenic activity of tea towards 2-hydroxyamino-3-methylimidazo[4,5-f]quinoline: effect of tea concentration and brew time on electrophile scavenging.
Mutation research 1998;402(1-2):299-306.
1998: Roderick H Dashwood; T Negishi; H Hayatsu; V Breinholt; Jerry D Hendricks; George Bailey
Chemopreventive properties of chlorophylls towards aflatoxin B1: a review of the antimutagenicity and anticarcinogenicity data in rainbow trout.
Mutation research 1998;399(2):245-53.
1998: George S Bailey; Roderick H Dashwood; PM Loveland; Cliff Pereira; Jerry D Hendricks
Molecular dosimetry in fish: quantitative target organ DNA adduction and hepatocarcinogenicity for four aflatoxins by two exposure routes in rainbow trout.
Mutation research 1998;399(2):233-44.
1998: Roderick H Dashwood
Indole-3-carbinol: anticarcinogen or tumor promoter in brassica vegetables?
Chemico-biological interactions 1998;110(1-2):1-5.
1997: Roderick H Dashwood
The importance of using pure chemicals in (anti) mutagenicity studies: chlorophyllin as a case in point.
Mutation research 1997;381(2):283-6.
1997: Meirong Xu; H A Schut; Leonard F Bjeldanes; D E Williams; George S Bailey; Roderick H Dashwood
Inhibition of 2-amino-3-methylimidazo[4,5-f]quinoline-DNA adducts by indole-3-carbinol: dose-response studies in the rat colon.
Carcinogenesis 1997;18(11):2149-53.
1997: NW Hasaniya; K Youn; Meirong Xu; JF Hernaez; Roderick H Dashwood
Inhibitory activity of green and black tea in a free radical-generating system using 2-amino-3-methylimidazo[4,5-f]quinoline as substrate.
Japanese journal of cancer research : Gann 1997;88(6):553-8.
1997: JF Hernaez; Meirong Xu; Roderick H Dashwood
Effects of tea and chlorophyllin on the mutagenicity of N-hydroxy-IQ: studies of enzyme inhibition, molecular complex formation, and degradation/scavenging of the active metabolites.
Environmental and molecular mutagenesis 1997;30(4):468-74.
1996: R Hayashi; H Luk; D Horio; Roderick H Dashwood
Inhibition of apoptosis in colon tumors induced in the rat by 2-amino-3-methylimidazo[4,5-f]quinoline.
Cancer research 1996;56(19):4307-10.
1996: Meirong Xu; A C Bailey; JF Hernaez; C R Taoka; H A Schut; Roderick H Dashwood
Protection by green tea, black tea, and indole-3-carbinol against 2-amino-3-methylimidazo[4,5-f]quinoline-induced DNA adducts and colonic aberrant crypts in the F344 rat.
Carcinogenesis 1996;17(7):1429-34.
1996: Roderick H Dashwood; S Yamane; R Larsen
Study of the forces of stabilizing complexes between chlorophylls and heterocyclic amine mutagens.
Environmental and molecular mutagenesis 1996;27(3):211-8.
1995: C Liew; H A Schut; S F Chin; Michael W Pariza; Roderick H Dashwood
Protection of conjugated linoleic acids against 2-amino-3- methylimidazo[4,5-f]quinoline-induced colon carcinogenesis in the F344 rat: a study of inhibitory mechanisms.
Carcinogenesis 1995;16(12):3037-43.
1995: D Guo; H A Schut; C D Davis; E G Snyderwine; George S Bailey; Roderick H Dashwood
Protection by chlorophyllin and indole-3-carbinol against 2-amino-1-methyl-6-phenylimidazo[4,5-b]pyridine (PhIP)-induced DNA adducts and colonic aberrant crypts in the F344 rat.
Carcinogenesis 1995;16(12):2931-7.
1995: N Takahashi; Roderick H Dashwood; L F Bjeldanes; David E Williams; George S Bailey
Mechanisms of indole-3-carbinol (I3C) anticarcinogenesis: inhibition of aflatoxin B1-DNA adduction and mutagenesis by I3C acid condensation products.
Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association 1995;33(10):851-7.
1995: D Guo; D T Horio; J S Grove; Roderick H Dashwood
Inhibition by chlorophyllin of 2-amino-3-methylimidazo-[4,5-f]quinoline-induced tumorigenesis in the male F344 rat.
Cancer letters 1995;95(1-2):161-5.
1995: V Breinholt; Michael I Schimerlik; Roderick H Dashwood; George Bailey
Mechanisms of chlorophyllin anticarcinogenesis against aflatoxin B1: complex formation with the carcinogen.
Chemical research in toxicology 1995;8(4):506-14.
1995: N Tachino; R Hayashi; C Liew; George Bailey; Roderick H Dashwood
Evidence for ras gene mutation in 2-amino-3-methylimidazo[4,5-f]quinoline-induced colonic aberrant crypts in the rat.
Molecular carcinogenesis 1995;12(4):187-92.
1995: N Takahashi; Roderick H Dashwood; L F Bjeldanes; George S Bailey; David E Williams
Regulation of hepatic cytochrome P4501A by indole-3-carbinol: transient induction with continuous feeding in rainbow trout.
Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association 1995;33(2):111-20.
1995: Roderick H Dashwood; D Guo
Protective properties of chlorophylls against the covalent binding of heterocyclic amines to DNA in vitro and in vivo.
Princess Takamatsu symposia 1995;23():181-9.
1994: N Tachino; D Guo; WM Dashwood; S Yamane; R Larsen; Roderick H Dashwood
Mechanisms of the in vitro antimutagenic action of chlorophyllin against benzo[a]pyrene: studies of enzyme inhibition, molecular complex formation and degradation of the ultimate carcinogen.
Mutation research 1994;308(2):191-203.
1994: Roderick H Dashwood; A T Fong; D Arbogast; L F Bjeldanes; Jerry D Hendricks; George S Bailey
Anticarcinogenic activity of indole-3-carbinol acid products: ultrasensitive bioassay by trout embryo microinjection.
Cancer research 1994;54(13):3617-9.
1994: D Guo; Roderick H Dashwood
Inhibition of 2-amino-3-methylimidazo[4,5-f]quinoline (IQ)-DNA binding in rats given chlorophyllin: dose-response and time-course studies in the liver and colon.
Carcinogenesis 1994;15(4):763-6.
1993: A T Fong; Roderick H Dashwood; R Cheng; C Mathews; B Ford; Jerry D Hendricks; George S Bailey
Carcinogenicity, metabolism and Ki-ras proto-oncogene activation by 7,12-dimethylbenz[a]anthracene in rainbow trout embryos.
Carcinogenesis 1993;14(4):629-35.
1993: Roderick H Dashwood; D Guo
Antimutagenic potency of chlorophyllin in the Salmonella assay and its correlation with binding constants of mutagen-inhibitor complexes.
Environmental and molecular mutagenesis 1993;22(3):164-71.
1992: Roderick H Dashwood; D Guo
Inhibition of 2-amino-3-methylimidazo[4,5-f]quinoline (IQ)-DNA binding by chlorophyllin: studies of enzyme inhibition and molecular complex formation.
Carcinogenesis 1992;13(7):1121-6.
1992: George Bailey; Jerry D Hendricks; Roderick H Dashwood
Anticarcinogenesis in fish.
Mutation research 1992;267(2):243-50.
1992: Roderick H Dashwood
Protection by chlorophyllin against the covalent binding of 2-amino-3-methylimidazo[4,5-f]quinoline (IQ) to rat liver DNA.
Carcinogenesis 1992;13(1):113-8.
1992: Roderick H Dashwood; C Liew
Chlorophyllin-enhanced excretion of urinary and fecal mutagens in rats given 2-amino-3-methylimidazo[4,5-f]quinoline.
Environmental and molecular mutagenesis 1992;20(3):199-205.
1991: Roderick H Dashwood; V Breinholt; George S Bailey
Chemopreventive properties of chlorophyllin: inhibition of aflatoxin B1 (AFB1)-DNA binding in vivo and anti-mutagenic activity against AFB1 and two heterocyclic amines in the Salmonella mutagenicity assay.
Carcinogenesis 1991;12(5):939-42.
1991: Roderick H Dashwood; A T Fong; David E Williams; Jerry D Hendricks; George S Bailey
Promotion of aflatoxin B1 carcinogenesis by the natural tumor modulator indole-3-carbinol: influence of dose, duration, and intermittent exposure on indole-3-carbinol promotional potency.
Cancer research 1991;51(9):2362-5.
1991: George S Bailey; Roderick H Dashwood; A T Fong; David E Williams; R A Scanlan; Jerry D Hendricks
Modulation of mycotoxin and nitrosamine carcinogenesis by indole-3-carbinol: quantitative analysis of inhibition versus promotion.
IARC scientific publications 1991;(105):275-80.
1990: Roderick H Dashwood; P M Loveland; A T Fong; Jerry D Hendricks; George S Bailey
Combined in vivo DNA binding and tumor dose-response studies to investigate the molecular dosimetry concept.
Progress in clinical and biological research 1990;340D():335-44.
1990: Roderick H Dashwood; A T Fong; Jerry D Hendricks; George S Bailey
Tumor dose-response studies with aflatoxin B1 and the ambivalent modulator indole-3-carbinol: inhibitory versus promotional potency.
Basic life sciences 1990;52():361-5.
1990: A T Fong; H I Swanson; Roderick H Dashwood; David E Williams; Jerry D Hendricks; George S Bailey
Mechanisms of anti-carcinogenesis by indole-3-carbinol. Studies of enzyme induction, electrophile-scavenging, and inhibition of aflatoxin B1 activation.
Biochemical pharmacology 1990;39(1):19-26.
1989: Roderick H Dashwood; L Uyetake; A T Fong; Jerry D Hendricks; George S Bailey
In vivo disposition of the natural anti-carcinogen indole-3-carbinol after po administration to rainbow trout.
Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association 1989;27(6):385-92.
1989: Roderick H Dashwood; D Arbogast; A T Fong; Cliff Pereira; Jerry D Hendricks; George S Bailey
Quantitative inter-relationships between aflatoxin B1 carcinogen dose, indole-3-carbinol anti-carcinogen dose, target organ DNA adduction and final tumor response.
Carcinogenesis 1989;10(1):175-81.
1988: A T Fong; Jerry D Hendricks; Roderick H Dashwood; S Van Winkle; B C Lee; George S Bailey
Modulation of diethylnitrosamine-induced hepatocarcinogenesis and O6-ethylguanine formation in rainbow trout by indole-3-carbinol, beta-naphthoflavone, and Aroclor 1254.
Toxicology and applied pharmacology 1988;96(1):93-100.
1988: A T Fong; Jerry D Hendricks; Roderick H Dashwood; S Van Winkle; George S Bailey
Formation and persistence of ethylguanines in liver DNA of rainbow trout (Salmo gairdneri) treated with diethylnitrosamine by water exposure.
Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association 1988;26(8):699-704.
1988: Roderick H Dashwood; D Arbogast; A T Fong; Jerry D Hendricks; George S Bailey
Mechanisms of anti-carcinogenesis by indole-3-carbinol: detailed in vivo DNA binding dose-response studies after dietary administration with aflatoxin B1.
Carcinogenesis 1988;9(3):427-32.