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Margitta Dathe

Research Profile

Genes & Molecular Sequences

Amino Acid Sequences

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Publications

TOP 3
Mojtaba Bagheri; Michael Beyermann; Margitta Dathe
Mode of action of cationic antimicrobial peptides defines the tethering position and the efficacy of biocidal surfaces.
Christof Junkes; Richard D Harvey; Kenneth D Bruce; Rudolf Dölling; Mojtaba Bagheri; Margitta Dathe
Cyclic antimicrobial R-, W-rich peptides: the role of peptide structure and E. coli outer and inner membranes in activity and the mode of action.
Mojtaba Bagheri; Sandro Keller; Margitta Dathe
Interaction of W-substituted analogs of cyclo-RRRWFW with bacterial lipopolysaccharides: the role of the aromatic cluster in antimicrobial activity.

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All Publications

2012: Mojtaba Bagheri; Michael Beyermann; Margitta Dathe
Mode of action of cationic antimicrobial peptides defines the tethering position and the efficacy of biocidal surfaces.
Bioconjugate chemistry 2012;23(1):66-74.
2011: Christof Junkes; Richard D Harvey; Kenneth D Bruce; Rudolf Dölling; Mojtaba Bagheri; Margitta Dathe
Cyclic antimicrobial R-, W-rich peptides: the role of peptide structure and E. coli outer and inner membranes in activity and the mode of action.
European biophysics journal : EBJ 2011;40(4):515-28.
2011: Mojtaba Bagheri; Sandro Keller; Margitta Dathe
Interaction of W-substituted analogs of cyclo-RRRWFW with bacterial lipopolysaccharides: the role of the aromatic cluster in antimicrobial activity.
Antimicrobial agents and chemotherapy 2011;55(2):788-97.
2010: Tobias Blaschke; T Spangenberg; P Schlupp; Margitta Dathe; W Szcymczak; Wolfgang Mehnert; Hans Korting; S Thalhammer; H Niehus; Monika Schäfer-Korting; Klaus D Kramer
Interaction of drug-carrier systems with targets--a study using atomic force microscopy.
Die Pharmazie 2010;65(9):657-64.
2009: Andreas Erbe; Andreas Kerth; Margitta Dathe; Alfred Blume
Interactions of KLA amphipathic model peptides with lipid monolayers.
Chembiochem : a European journal of chemical biology 2009;10(18):2884-92.
2009: Hend M Shubar; Ildiko R Dunay; Sabrina Lachenmaier; Margitta Dathe; Faris Nadiem Bushrab; Rachmat Mauludin; Rainer H Müller; Rudolf Fitzner; Klaus Borner; Oliver Liesenfeld
The role of apolipoprotein E in uptake of atovaquone into the brain in murine acute and reactivated toxoplasmosis.
Journal of drug targeting 2009;17(4):257-67.
2009: Ahmad Arouri; Margitta Dathe; Alfred Blume
Peptide induced demixing in PG/PE lipid mixtures: a mechanism for the specificity of antimicrobial peptides towards bacterial membranes?
Biochimica et biophysica acta 2009;1788(3):650-9.
2009: Mojtaba Bagheri; Michael Beyermann; Margitta Dathe
Immobilization reduces the activity of surface-bound cationic antimicrobial peptides with no influence upon the activity spectrum.
Antimicrobial agents and chemotherapy 2009;53(3):1132-41.
2009: Eik Leupold; Heike Nikolenko; Margitta Dathe
Apolipoprotein E peptide-modified colloidal carriers: the design determines the mechanism of uptake in vascular endothelial cells.
Biochimica et biophysica acta 2009;1788(2):442-9.
2009: Sarah Küchler; Michal R Radowski; Tobias Blaschke; Margitta Dathe; Johanna Plendl; Rainer Haag; Monika Schäfer-Korting; Klaus D Kramer
Nanoparticles for skin penetration enhancement--a comparison of a dendritic core-multishell-nanotransporter and solid lipid nanoparticles.
European journal of pharmaceutics and biopharmaceutics : official journal of Arbeitsgemeinschaft für Pharmazeutische Verfahrenstechnik e.V 2009;71(2):243-50.
2009: Esad Vucic; Honorius M H F Sanders; Francesca Arena; Enzo Terreno; Silvio Aime; Klaas Nicolay; Eik Leupold; Margitta Dathe; Nico Sommerdijk; Zahi A Fayad; Willem J M Mulder
Well-defined, multifunctional nanostructures of a paramagnetic lipid and a lipopeptide for macrophage imaging.
Journal of the American Chemical Society 2009;131(2):406-7.
2008: Eik Leupold; Heike Nikolenko; Michael Beyermann; Margitta Dathe
Insight into the role of HSPG in the cellular uptake of apolipoprotein E-derived peptide micelles and liposomes.
Biochimica et biophysica acta 2008;1778(12):2781-9.
2008: Miguel A R B Castanho; Margitta Dathe
Biophysics meets membrane-active peptides.
Journal of peptide science : an official publication of the European Peptide Society 2008;14(4):365-7.
2008: Christof Junkes; Axel Wessolowski; Sebastien Farnaud; Robert W Evans; Liam Good; Michael Bienert; Margitta Dathe
The interaction of arginine- and tryptophan-rich cyclic hexapeptides with Escherichia coli membranes.
Journal of peptide science : an official publication of the European Peptide Society 2008;14(4):535-43.
2008: Christian Appelt; Axel Wessolowski; Margitta Dathe; Peter Schmieder
Structures of cyclic, antimicrobial peptides in a membrane-mimicking environment define requirements for activity.
Journal of peptide science : an official publication of the European Peptide Society 2008;14(4):524-7.
2007: Stephan Pritz; Michael Pätzel; Günter Szeimies; Margitta Dathe; Michael Bienert
Synthesis of a chiral amino acid with bicyclo[1.1.1]pentane moiety and its incorporation into linear and cyclic antimicrobial peptides.
Organic & biomolecular chemistry 2007;5(11):1789-94.
2007: Antje Voigt; Ulrike Salzmann; Ulrike Seifert; Margitta Dathe; Alejandro Soza; Peter-M Kloetzel; Ulrike Kuckelkorn
20S proteasome-dependent generation of an IEpp89 murine cytomegalovirus-derived H-2L(d) epitope from a recombinant protein.
Biochemical and biophysical research communications 2007;355(2):549-54.
2007: Sandro Keller; Matthias Böthe; Michael Bienert; Margitta Dathe; Alfred Blume
A simple fluorescence-spectroscopic membrane translocation assay.
Chembiochem : a European journal of chemical biology 2007;8(5):546-52.
2006: Christian Hundsrucker; Gerd Krause; Michael Beyermann; Anke Prinz; Bastian Zimmermann; Oliver Diekmann; Dorothea Lorenz; Eduard Stefan; Pavel I Nedvetsky; Margitta Dathe; Frank Christian; Theresa McSorley; Eberhard Krause; George McConnachie; Friedrich W Herberg; John D Scott; Walter Rosenthal; Enno Klussmann
High-affinity AKAP7delta-protein kinase A interaction yields novel protein kinase A-anchoring disruptor peptides.
The Biochemical journal 2006;396(2):297-306.
2006: Ines Sauer; Heike Nikolenko; Sandro Keller; Khalid Abu Ajaj; Michael Bienert; Margitta Dathe
Dipalmitoylation of a cellular uptake-mediating apolipoprotein E-derived peptide as a promising modification for stable anchorage in liposomal drug carriers.
Biochimica et biophysica acta 2006;1758(4):552-61.
2005: Elsa Bárány-Wallje; Sandro Keller; Steffen Serowy; Sebastian Geibel; Peter Pohl; Michael Bienert; Margitta Dathe
A critical reassessment of penetratin translocation across lipid membranes.
Biophysical journal 2005;89(4):2513-21.
2005: Christian Appelt; Axel Wessolowski; J Arvid Söderhäll; Margitta Dathe; Peter Schmieder
Structure of the antimicrobial, cationic hexapeptide cyclo(RRWWRF) and its analogues in solution and bound to detergent micelles.
Chembiochem : a European journal of chemical biology 2005;6(9):1654-62.
2005: Sandro Keller; Ines Sauer; Holger Strauss; Klaus Gast; Margitta Dathe; Michael Bienert
Membrane-mimetic nanocarriers formed by a dipalmitoylated cell-penetrating peptide.
Angewandte Chemie (International ed. in English) 2005;44(33):5252-5.
2005: Ines Sauer; Ildiko R Dunay; Karl H Weisgraber; Michael Bienert; Margitta Dathe
An apolipoprotein E-derived peptide mediates uptake of sterically stabilized liposomes into brain capillary endothelial cells.
Biochemistry 2005;44(6):2021-9.
2004: A Wessolowski; Michael Bienert; Margitta Dathe
Antimicrobial activity of arginine- and tryptophan-rich hexapeptides: the effects of aromatic clusters, D-amino acid substitution and cyclization.
The journal of peptide research : official journal of the American Peptide Society 2004;64(4):159-69.
2004: Margitta Dathe; Heike Nikolenko; Jana Klose; Michael Bienert
Cyclization increases the antimicrobial activity and selectivity of arginine- and tryptophan-containing hexapeptides.
Biochemistry 2004;43(28):9140-50.
2004: Andreas Kerth; Andreas Erbe; Margitta Dathe; Alfred Blume
Infrared reflection absorption spectroscopy of amphipathic model peptides at the air/water interface.
Biophysical journal 2004;86(6):3750-8.
2002: Lucia Kuhn-Nentwig; Margitta Dathe; Alfred Walz; Johann Schaller; Wolfgang Nentwig
Cupiennin 1d*: the cytolytic activity depends on the hydrophobic N-terminus and is modulated by the polar C-terminus.
FEBS letters 2002;527(1-3):193-8.
2002: Lucia Kuhn-Nentwig; Jurg Muller; Johann Schaller; Alfred Walz; Margitta Dathe; Wolfgang Nentwig
Cupiennin 1, a new family of highly basic antimicrobial peptides in the venom of the spider Cupiennius salei (Ctenidae).
The Journal of biological chemistry 2002;277(13):11208-16.
2002: Margitta Dathe; Jana Meyer; Michael Beyermann; Björn Maul; Christian Hoischen; Michael Bienert
General aspects of peptide selectivity towards lipid bilayers and cell membranes studied by variation of the structural parameters of amphipathic helical model peptides.
Biochimica et biophysica acta 2002;1558(2):171-86.
2001: Margitta Dathe; Heike Nikolenko; J Meyer; Michael Beyermann; Michael Bienert
Optimization of the antimicrobial activity of magainin peptides by modification of charge.
FEBS letters 2001;501(2-3):146-50.
2001: A L Salmon; L J Cross; Alexandra E Irvine; Terence R J Lappin; Margitta Dathe; Gerd Krause; P Canning; L Thim; Michael Beyermann; Sven Rothemund; Michael Bienert; C Shaw
Peptide leucine arginine, a potent immunomodulatory peptide isolated and structurally characterized from the skin of the Northern Leopard frog, Rana pipiens.
The Journal of biological chemistry 2001;276(13):10145-52.
2000: P Müller; Stephan Schiller; Torsten Wieprecht; Margitta Dathe; A Herrmann
Continuous measurement of rapid transbilayer movement of a pyrene-labeled phospholipid analogue.
Chemistry and physics of lipids 2000;106(1):89-99.
2000: Michael Beyermann; Sven Rothemund; Nadja Heinrich; Klaus Fechner; Jens Furkert; Margitta Dathe; R Winter; Eberhard Krause; Michael Bienert
A role for a helical connector between two receptor binding sites of a long-chain peptide hormone.
The Journal of biological chemistry 2000;275(8):5702-9.
1999: Margitta Dathe; Torsten Wieprecht
Structural features of helical antimicrobial peptides: their potential to modulate activity on model membranes and biological cells.
Biochimica et biophysica acta 1999;1462(1-2):71-87.
1999: Eberhard Krause; Margitta Dathe; Torsten Wieprecht; Michael Bienert
Noncovalent immobilized artificial membrane chromatography, an improved method for describing peptide-lipid bilayer interactions.
Journal of chromatography. A 1999;849(1):125-33.
1999: A Scheller; Johannes Oehlke; Burkhard Wiesner; Margitta Dathe; Eberhard Krause; Michael Beyermann; MF Melzig; Michael Bienert
Structural requirements for cellular uptake of alpha-helical amphipathic peptides.
Journal of peptide science : an official publication of the European Peptide Society 1999;5(4):185-94.
1998: C Kaduk; Margitta Dathe; Michael Bienert
Functional modifications of alamethicin ion channels by substitution of glutamine 7, glycine 11 and proline 14.
Biochimica et biophysica acta 1998;1373(1):137-46.
1998: Margitta Dathe; C Kaduk; E Tachikawa; MF Melzig; Holger Wenschuh; Michael Bienert
Proline at position 14 of alamethicin is essential for hemolytic activity, catecholamine secretion from chromaffin cells and enhanced metabolic activity in endothelial cells.
Biochimica et biophysica acta 1998;1370(1):175-83.
1997: Torsten Wieprecht; Margitta Dathe; Eberhard Krause; Michael Beyermann; W Lee Maloy; DL MacDonald; Michael Bienert
Modulation of membrane activity of amphipathic, antibacterial peptides by slight modifications of the hydrophobic moment.
FEBS letters 1997;417(1):135-40.
1997: Torsten Wieprecht; Margitta Dathe; Richard M Epand; Michael Beyermann; Eberhard Krause; W Lee Maloy; DL MacDonald; Michael Bienert
Influence of the angle subtended by the positively charged helix face on the membrane activity of amphipathic, antibacterial peptides.
Biochemistry 1997;36(42):12869-80.
1997: Torsten Wieprecht; Margitta Dathe; Michael Beyermann; Eberhard Krause; W Lee Maloy; DL MacDonald; Michael Bienert
Peptide hydrophobicity controls the activity and selectivity of magainin 2 amide in interaction with membranes.
Biochemistry 1997;36(20):6124-32.
1997: C Kaduk; Hervé Duclohier; Margitta Dathe; Holger Wenschuh; Michael Beyermann; Gérard Molle; Michael Bienert
Influence of proline position upon the ion channel activity of alamethicin.
Biophysical journal 1997;72(5):2151-9.
1997: M Schümann; Margitta Dathe; Torsten Wieprecht; Michael Beyermann; Michael Bienert
The tendency of magainin to associate upon binding to phospholipid bilayers.
Biochemistry 1997;36(14):4345-51.
1997: Margitta Dathe; Torsten Wieprecht; Heike Nikolenko; L Handel; W Lee Maloy; DL MacDonald; Michael Beyermann; Michael Bienert
Hydrophobicity, hydrophobic moment and angle subtended by charged residues modulate antibacterial and haemolytic activity of amphipathic helical peptides.
FEBS letters 1997;403(2):208-12.
1996: Eberhard Krause; M Beyermann; Heinz Fabian; Margitta Dathe; Sven Rothemund; Michael Bienert
Conformation of a water-soluble beta-sheet model peptide. A circular dichroism and Fourier-transform infrared spectroscopic study of double D-amino acid replacements.
International journal of peptide and protein research 1996;48(6):559-68.
1996: Margitta Dathe; M Schümann; Torsten Wieprecht; Anett Winkler; M Beyermann; Eberhard Krause; K Matsuzaki; O Murase; Michael Bienert
Peptide helicity and membrane surface charge modulate the balance of electrostatic and hydrophobic interactions with lipid bilayers and biological membranes.
Biochemistry 1996;35(38):12612-22.
1996: Torsten Wieprecht; Margitta Dathe; M Schümann; Eberhard Krause; M Beyermann; Michael Bienert
Conformational and functional study of magainin 2 in model membrane environments using the new approach of systematic double-D-amino acid replacement.
Biochemistry 1996;35(33):10844-53.
1996: Margitta Dathe; Heinz Fabian; Klaus Gast; Dietrich Zirwer; R Winter; M Beyermann; M Schümann; Michael Bienert
Conformational differences of ovine and human corticotropin releasing hormone. A CD, IR, NMR and dynamic light scattering study.
International journal of peptide and protein research 1996;47(5):383-93.
1996: Sven Rothemund; Eberhard Krause; M Beyermann; Margitta Dathe; Michael Bienert; R S Hodges; B D Sykes; F D Sönnichsen
Peptide destabilization by two adjacent D-amino acids in single-stranded amphipathic alpha-helices.
Peptide research 1996;9(2):79-87.
1995: L J Cross; Madeleine Ennis; Eberhard Krause; Margitta Dathe; D Lorenz; Gerd Krause; M Beyermann; Michael Bienert
Influence of alpha-helicity, amphipathicity and D-amino acid incorporation on the peptide-induced mast cell activation.
European journal of pharmacology 1995;291(3):291-300.
1995: Eberhard Krause; M Beyermann; Margitta Dathe; Sven Rothemund; Michael Bienert
Location of an amphipathic alpha-helix in peptides using reversed-phase HPLC retention behavior of D-amino acid analogs.
Analytical chemistry 1995;67(2):252-8.
1995: Sven Rothemund; Eberhard Krause; M Beyermann; Margitta Dathe; H Engelhardt; Michael Bienert
Recognition of alpha-helical peptide structures using high-performance liquid chromatographic retention data for D-amino acid analogues: influence of peptide amphipathicity and of stationary phase hydrophobicity.
Journal of chromatography. A 1995;689(2):219-26.
1992: Volker Hagen; G Reck; Margitta Dathe; H J Jänsch; M Feist
[Potential cardiotonics. 15. Crystal modifications of 3-cyano-2-morpholino-5-(4-pyridinyl)pyridine (AWD 122-14)].
Die Pharmazie 1992;47(10):777-80.
1990: Margitta Dathe; Klaus Gast; Dietrich Zirwer; Heinz Welfle; B Mehlis
Insulin aggregation in solution.
International journal of peptide and protein research 1990;36(4):344-9.
1988: E Klauschenz; Volker Hagen; B Gentsch; H Niedrich; Margitta Dathe; G Reck; H J Jänsch
[Crystal modifications of 3-cyan-6-methyl-5-(pyrid-4-yl)-1,2-dihydropyrid-2-one (milrinone)].
Die Pharmazie 1988;43(3):167-9.