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Jharna Datta

Research Profile

Chemicals & Drugs

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Publications

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Swarna A Gamage; Samson T Jacob; Sanjeev Redkar; Darby G Brooke; Jharna Datta; William A Denny
Structure-activity relationships for 4-anilinoquinoline derivatives as inhibitors of the DNA methyltransferase enzyme DNMT1.
Longzhu Piao; Tizhi Su; Theodoros N Teknos; Xiujie Xie; Manchao Zhang; Jharna Datta; Hong Li; Quintin Pan
Lipid-based nanoparticle delivery of Pre-miR-107 inhibits the tumorigenicity of head and neck squamous cell carcinoma.
Huban Kutay; Sarmila Majumder; Craig McClain; Tasneem Motiwala; Bo Wang; Lianbo Yu; Xiaoli Zhang; Shu-hao Hsu; Samson Jacob; Nuzhat Khan; Corie Klepper; Martha Belury; Jharna Datta; Kalpana Ghoshal
Reduced susceptibility of DNA methyltransferase 1 hypomorphic (Dnmt1N/+) mice to hepatic steatosis upon feeding liquid alcohol diet.

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All Publications

2013: Swarna A Gamage; Samson T Jacob; Sanjeev Redkar; Darby G Brooke; Jharna Datta; William A Denny
Structure-activity relationships for 4-anilinoquinoline derivatives as inhibitors of the DNA methyltransferase enzyme DNMT1.
Bioorganic & medicinal chemistry 2013;21(11):3147-53.
2012: Longzhu Piao; Tizhi Su; Theodoros N Teknos; Xiujie Xie; Manchao Zhang; Jharna Datta; Hong Li; Quintin Pan
Lipid-based nanoparticle delivery of Pre-miR-107 inhibits the tumorigenicity of head and neck squamous cell carcinoma.
Molecular therapy : the journal of the American Society of Gene Therapy 2012;20(6):1261-9.
2012: Huban Kutay; Sarmila Majumder; Craig McClain; Tasneem Motiwala; Bo Wang; Lianbo Yu; Xiaoli Zhang; Shu-hao Hsu; Samson Jacob; Nuzhat Khan; Corie Klepper; Martha Belury; Jharna Datta; Kalpana Ghoshal
Reduced susceptibility of DNA methyltransferase 1 hypomorphic (Dnmt1N/+) mice to hepatic steatosis upon feeding liquid alcohol diet.
PloS one 2012;7(8):e41949.
2012: Jharna Datta; Kalpana Ghoshal; Tasneem Motiwala; Samson T Jacob
Novel Insights into the Molecular Mechanism of Action of DNA Hypomethylating Agents: Role of Protein Kinase C δ in Decitabine-Induced Degradation of DNA Methyltransferase 1.
Genes & cancer 2012;3(1):71-81.
2011: Tasneem Motiwala; Satavisha Roy; nicola zanesi; Yiming Zhong; John C Byrd; Allyn M Checovich; Carlo M Croce; Jharna Datta; John Patrick Hagan; Nyla A Heerema; David Jarjoura; Amy J Johnson; Mohamed Kaou; Huban Kutay; David M Lucas; Xiaokui Mo; Samson T Jacob
AP-1 elements and TCL1 protein regulate expression of the gene encoding protein tyrosine phosphatase PTPROt in leukemia.
Blood 2011;118(23):6132-40.
2010: Tasneem Motiwala; Jharna Datta; Huban Kutay; Satavisha Roy; Samson T Jacob
Lyn kinase and ZAP70 are substrates of PTPROt in B-cells: Lyn inactivation by PTPROt sensitizes leukemia cells to VEGF-R inhibitor pazopanib.
Journal of cellular biochemistry 2010;110(4):846-56.
2010: Sarmila Majumder; Lapo Alinari; Satavisha Roy; Tyler Miller; Jharna Datta; Saïd Sif; Robert A Baiocchi; Samson T Jacob
Methylation of histone H3 and H4 by PRMT5 regulates ribosomal RNA gene transcription.
Journal of cellular biochemistry 2010;109(3):553-63.
2010: Kalpana Ghoshal; Tasneem Motiwala; Rainer Claus; Pearlly Yan; Huban Kutay; Jharna Datta; Sarmila Majumder; Shoumei Bai; Arnab Majumder; Hui-Ming (Tim) Huang; Christoph Plass; Samson T Jacob
HOXB13, a target of DNMT3B, is methylated at an upstream CpG island, and functions as a tumor suppressor in primary colorectal tumors.
PloS one 2010;5(4):e10338.
2009: Shoumei Bai; Mohd W Nasser; Bo Wang; Shu-Hao Hsu; Jharna Datta; Huban Kutay; Arti Yadav; Gerard J Nuovo; Pawan Kumar; Kalpana Ghoshal
MicroRNA-122 inhibits tumorigenic properties of hepatocellular carcinoma cells and sensitizes these cells to sorafenib.
The Journal of biological chemistry 2009;284(46):32015-27.
2009: Jharna Datta; Kalpana Ghoshal; William A Denny; Swarna A Gamage; Darby G Brooke; Pasit Phiasivongsa; Sanjeev Redkar; Samson T Jacob
A new class of quinoline-based DNA hypomethylating agents reactivates tumor suppressor genes by blocking DNA methyltransferase 1 activity and inducing its degradation.
Cancer research 2009;69(10):4277-85.
2009: Bhuvaneswari Ramaswamy; Sarmila Majumder; Satavisha Roy; Kalpana Ghoshal; Huban Kutay; Jharna Datta; Mamoun Younes; Charles L Shapiro; Tasneem Motiwala; Samson T Jacob
Estrogen-mediated suppression of the gene encoding protein tyrosine phosphatase PTPRO in human breast cancer: mechanism and role in tamoxifen sensitivity.
Molecular endocrinology (Baltimore, Md.) 2009;23(2):176-87.
2009: Tasneem Motiwala; Sarmila Majumder; Kalpana Ghoshal; Huban Kutay; Jharna Datta; Satavisha Roy; David M Lucas; Samson T Jacob
PTPROt inactivates the oncogenic fusion protein BCR/ABL and suppresses transformation of K562 cells.
The Journal of biological chemistry 2009;284(1):455-64.
2008: Jharna Datta; Huban Kutay; Mohd W Nasser; Gerard J Nuovo; Bo Wang; Sarmila Majumder; Chang-gong liu; Stefano Volinia; Carlo M Croce; Thomas D Schmittgen; Kalpana Ghoshal; Samson T Jacob
Methylation mediated silencing of MicroRNA-1 gene and its role in hepatocellular carcinogenesis.
Cancer research 2008;68(13):5049-58.
2007: Shoumei Bai; Jharna Datta; Samson T Jacob; Kalpana Ghoshal
Treatment of PC12 cells with nerve growth factor induces proteasomal degradation of T-cadherin that requires tyrosine phosphorylation of its cadherin domain.
The Journal of biological chemistry 2007;282(37):27171-80.
2007: Jharna Datta; Sarmila Majumder; Huban Kutay; Tasneem Motiwala; Wendy Frankel; Robert Costa; Hyuk C Cha; Ormond A MacDougald; Samson T Jacob; Kalpana Ghoshal
Metallothionein expression is suppressed in primary human hepatocellular carcinomas and is mediated through inactivation of CCAAT/enhancer binding protein alpha by phosphatidylinositol 3-kinase signaling cascade.
Cancer research 2007;67(6):2736-46.
2006: Huban Kutay; Shoumei Bai; Jharna Datta; Tasneem Motiwala; Igor P Pogribny; Wendy Frankel; Samson T Jacob; Kalpana Ghoshal
Downregulation of miR-122 in the rodent and human hepatocellular carcinomas.
Journal of cellular biochemistry 2006;99(3):671-8.
2006: Sarmila Majumder; Kalpana Ghoshal; Jharna Datta; David Spencer Smith; Shoumei Bai; Samson T Jacob
Role of DNA methyltransferases in regulation of human ribosomal RNA gene transcription.
The Journal of biological chemistry 2006;281(31):22062-72.
2006: Kalpana Ghoshal; Xin Li; Jharna Datta; Shoumei Bai; Igor P Pogribny; Marta Pogribny; Yan Huang; Donn Young; Samson T Jacob
A folate- and methyl-deficient diet alters the expression of DNA methyltransferases and methyl CpG binding proteins involved in epigenetic gene silencing in livers of F344 rats.
The Journal of nutrition 2006;136(6):1522-7.
2006: Sarmila Majumder; Huban Kutay; Jharna Datta; Dennis Summers; Samson T Jacob; Kalpana Ghoshal
Epigenetic regulation of metallothionein-i gene expression: differential regulation of methylated and unmethylated promoters by DNA methyltransferases and methyl CpG binding proteins.
Journal of cellular biochemistry 2006;97(6):1300-16.
2005: Jharna Datta; Sarmila Majumder; Shoumei Bai; Kalpana Ghoshal; Huban Kutay; David Spencer Smith; John W Crabb; Samson T Jacob
Physical and functional interaction of DNA methyltransferase 3A with Mbd3 and Brg1 in mouse lymphosarcoma cells.
Cancer research 2005;65(23):10891-900.
2005: Kalpana Ghoshal; Jharna Datta; Sarmila Majumder; Shoumei Bai; Huban Kutay; Tasneem Motiwala; Samson T Jacob
5-Aza-deoxycytidine induces selective degradation of DNA methyltransferase 1 by a proteasomal pathway that requires the KEN box, bromo-adjacent homology domain, and nuclear localization signal.
Molecular and cellular biology 2005;25(11):4727-41.
2005: Shoumei Bai; Kalpana Ghoshal; Jharna Datta; Sarmila Majumder; Sung Ok Yoon; Samson T Jacob
DNA methyltransferase 3b regulates nerve growth factor-induced differentiation of PC12 cells by recruiting histone deacetylase 2.
Molecular and cellular biology 2005;25(2):751-66.
2004: Kalpana Ghoshal; Sarmila Majumder; Jharna Datta; Tasneem Motiwala; Shoumei Bai; Sudarshana Sharma; Wendy Frankel; Samson T Jacob
Role of human ribosomal RNA (rRNA) promoter methylation and of methyl-CpG-binding protein MBD2 in the suppression of rRNA gene expression.
The Journal of biological chemistry 2004;279(8):6783-93.
2003: Sarmila Majumder; Kalpana Ghoshal; Dennis Summers; Shoumei Bai; Jharna Datta; Samson T Jacob
Chromium(VI) down-regulates heavy metal-induced metallothionein gene transcription by modifying transactivation potential of the key transcription factor, metal-responsive transcription factor 1.
The Journal of biological chemistry 2003;278(28):26216-26.
2003: Jharna Datta; Kalpana Ghoshal; Sudarshana Sharma; Shoji Tajima; Samson T Jacob
Biochemical fractionation reveals association of DNA methyltransferase (Dnmt) 3b with Dnmt1 and that of Dnmt 3a with a histone H3 methyltransferase and Hdac1.
Journal of cellular biochemistry 2003;88(5):855-64.
2002: Kalpana Ghoshal; Jharna Datta; Sarmila Majumder; Shoumei Bai; Xiaocheng Dong; Mark R Parthun; Samson T Jacob
Inhibitors of histone deacetylase and DNA methyltransferase synergistically activate the methylated metallothionein I promoter by activating the transcription factor MTF-1 and forming an open chromatin structure.
Molecular and cellular biology 2002;22(23):8302-19.
2002: Sarmila Majumder; Kalpana Ghoshal; Jharna Datta; Shoumei Bai; Xiaocheng Dong; Ning Quan; Christoph Plass; Samson T Jacob
Role of de novo DNA methyltransferases and methyl CpG-binding proteins in gene silencing in a rat hepatoma.
The Journal of biological chemistry 2002;277(18):16048-58.
2001: Kalpana Ghoshal; Sarmila Majumder; Q Zhu; John Hunzeker; Jharna Datta; M Shah; john sheridan; Samson T Jacob
Influenza virus infection induces metallothionein gene expression in the mouse liver and lung by overlapping but distinct molecular mechanisms.
Molecular and cellular biology 2001;21(24):8301-17.