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Alessandro Datti

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Gazelle J Crasto; Alessandro Datti; Norbert Kartner; Keying Li; Liv Bullock; Yeqi Yao; Morris F Manolson
Luteolin inhibition of V-ATPase a3-d2 interaction decreases osteoclast resorptive activity.
Julia Izrailit; Hal K Berman; Alessandro Datti; Jeffrey L Wrana; Michael Reedijk
High throughput kinase inhibitor screens reveal TRB3 and MAPK-ERK/TGFβ pathways as fundamental Notch regulators in breast cancer.
Sean McDermott; Mark D Minden; Faiyaz Notta; Jeff Wrana; Rima Al-Awar; Alessandro Datti; Kolja Eppert; Methvin Isaac; John E Dick
A small molecule screening strategy with validation on human leukemia stem cells uncovers the therapeutic efficacy of kinetin riboside.

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All Publications

2013: Gazelle J Crasto; Alessandro Datti; Norbert Kartner; Keying Li; Liv Bullock; Yeqi Yao; Morris F Manolson
Luteolin inhibition of V-ATPase a3-d2 interaction decreases osteoclast resorptive activity.
Journal of cellular biochemistry 2013;114(4):929-41.
2013: Julia Izrailit; Hal K Berman; Alessandro Datti; Jeffrey L Wrana; Michael Reedijk
High throughput kinase inhibitor screens reveal TRB3 and MAPK-ERK/TGFβ pathways as fundamental Notch regulators in breast cancer.
Proceedings of the National Academy of Sciences of the United States of America 2013;110(5):1714-9.
2012: Sean McDermott; Mark D Minden; Faiyaz Notta; Jeff Wrana; Rima Al-Awar; Alessandro Datti; Kolja Eppert; Methvin Isaac; John E Dick
A small molecule screening strategy with validation on human leukemia stem cells uncovers the therapeutic efficacy of kinetin riboside.
Blood 2012;119(5):1200-7.
2012: Richard Marcotte; Mauricio Medrano; Patricia Mero; Christine Misquitta; Glauber C Brito; Kevin R Brown; Alla Buzina; Alessandro Datti; Bohdana Fedyshyn; Yaroslav Fedyshyn; Maliha Haider; Konstantina Karamboulas; Dahlia Kasimer; Troy Ketela; Judice L Y Koh; Paul M Krzyzanowski; Marianna Luhova; Benjamin G Neel; Josee Normand; Robert Rottapel; Azin Sayad; Fabrice Sircoulomb; Fernando Suarez; Dewald van Dyk; Franco J Vizeacoumar; Frederick S Vizeacoumar; Jeffrey L Wrana; Jason Moffat
Essential gene profiles in breast, pancreatic, and ovarian cancer cells.
Cancer discovery 2012;2(2):172-89.
2012: Ke Jin; Jingjing Li; Zhijian Li; Renqiang Min; Frederick S Vizeacoumar; Franco Vizeacoumar; Lee Zamparo; Brenda Andrews; Charles Boone; Alessandro Datti; Zhaolei Zhang
PhenoM: a database of morphological phenotypes caused by mutation of essential genes in Saccharomyces cerevisiae.
Nucleic acids research 2012;40(Database issue):D687-94.
2011: Marko Skrtić; Paul Spagnuolo; Shrivani Sriskanthadevan; Jean C Y Wang; Xiaoming Wang; Zezhou Wang; Jeffery Wrana; Justyna Bartoszko; Jessie H Cameron; Alessandro Datti; John E Dick; Connie J Eaves; Yanina Eberhard; Marinella Gebbia; Guri Giaever; Marcela Gronda; Keith Humphries; Rose Hurren; Bozhena Jhas; Yulia Jitkova; Troy Ketela; Courteney K Lai; Neil Maclean; Mark D Minden; Jason Moffat; Corey Nislow; Brian H Robinson; Angela C Rutledge; Aaron D Schimmer
Inhibition of mitochondrial translation as a therapeutic strategy for human acute myeloid leukemia.
Cancer cell 2011;20(5):674-88.
2011: Ioannis Prassas; Ihor Batruch; Alessandro Datti; Apostolos Dimitromanolakis; George S Karagiannis; Eleftherios P Diamandis
Digitoxin-induced cytotoxicity in cancer cells is mediated through distinct kinase and interferon signaling networks.
Molecular cancer therapeutics 2011;10(11):2083-93.
2011: Elisa Leung; Jun Liu; Michelle Mah; Shannon E McCaw; Alina Nakhamchik; Koji Ogata; Emil F Pai; Shoshana J Wodak; Robert A Batey; Yi-Qiang Cheng; Michele Cossette; Alessandro Datti; Bryan T Eger; Majida El Bakkouri; Jordan Goodreid; Scott Gray-Owen; Walid A Houry
Activators of cylindrical proteases as antimicrobials: identification and development of small molecule activators of ClpP protease.
Chemistry & biology 2011;18(9):1167-78.
2011: Brent D G Page; Aaron D Schimmer; Sumaiya Sharmeen; Suzanne Trudel; James Turkson; Jeffrey L Wrana; Peibin Yue; Xiaolei Zhang; Alessandro Datti; Stephen Fletcher; Zhihua Li; Patrick T Gunning
Identification of a non-phosphorylated, cell permeable, small molecule ligand for the Stat3 SH2 domain.
Bioorganic & medicinal chemistry letters 2011;21(18):5605-9.
2011: Sabata Martino; Roberto Tiribuzi; Elisa Ciraci; Georgia Makrypidi; Francesco D'Angelo; Ilaria di Girolamo; Angela Gritti; Gabriella M Cusella de Angelis; Gianpaolo Papaccio; Maurilio Sampaolesi; Anna Concetta Berardi; Alessandro Datti; Aldo Orlacchio
Coordinated involvement of cathepsins S, D and cystatin C in the commitment of hematopoietic stem cells to dendritic cells.
The international journal of biochemistry & cell biology 2011;43(5):775-83.
2011: Yanina Eberhard; Marcela Gronda; Rose Hurren; Alessandro Datti; Neil MacLean; Troy Ketela; Jason Moffat; Jeffrey L Wrana; Aaron D Schimmer
Inhibition of SREBP1 sensitizes cells to death ligands.
Oncotarget 2011;2(3):186-96.
2011: Natalie Grinshtein; Alessandro Datti; Mayumi Fujitani; David Uehling; Michael Prakesch; Methvin Isaac; Meredith S Irwin; Jeffrey L Wrana; Rima Al-Awar; David R Kaplan
Small molecule kinase inhibitor screen identifies polo-like kinase 1 as a target for neuroblastoma tumor-initiating cells.
Cancer research 2011;71(4):1385-95.
2011: Xinliang Mao; Biyin Cao; Tabitha E Wood; Rose Hurren; Jiefei Tong; Xiaoming Wang; Wenjie Wang; Jie Li; Yueping Jin; Wenxian Sun; Paul A Spagnuolo; Neil MacLean; Michael F Moran; Alessandro Datti; Jeffrey L Wrana; Robert A Batey; Aaron D Schimmer
A small-molecule inhibitor of D-cyclin transactivation displays preclinical efficacy in myeloma and leukemia via phosphoinositide 3-kinase pathway.
Blood 2011;117(6):1986-97.
2011: Emma Ito; Shijun Yue; Eduardo H Moriyama; Angela B Hui; Inki Kim; Wei Shi; Nehad M Alajez; Nirmal Bhogal; Guohua Li; Alessandro Datti; Aaron D Schimmer; Brian C Wilson; Peter P Liu; Daniel Durocher; Benjamin G Neel; Brian O'Sullivan; Bernard Cummings; Rob Bristow; Jeff Wrana; Fei-Fei Liu
Uroporphyrinogen decarboxylase is a radiosensitizing target for head and neck cancer.
Science translational medicine 2011;3(67):67ra7.
2011: Roberto Tiribuzi; Mauro Zampolini; Giorgio Bernardi; Roberta Cecchetti; Lucia Crispoltoni; Alessandro Datti; Massimiliano De Angeliz; Mariangela Maiotti; Sabata Martino; Patrizia Mecocci; Antonio Orlacchio; Aldo Orlacchio
Lysosomal β-galactosidase and β-hexosaminidase activities correlate with clinical stages of dementia associated with Alzheimer's disease and type 2 diabetes mellitus.
Journal of Alzheimer's disease : JAD 2011;24(4):785-97.
2010: Norbert Kartner; Yeqi Yao; Keying Li; Gazelle J Crasto; Alessandro Datti; Morris F Manolson
Inhibition of osteoclast bone resorption by disrupting vacuolar H+-ATPase a3-B2 subunit interaction.
The Journal of biological chemistry 2010;285(48):37476-90.
2010: Lara O'Donnell; Stephanie Panier; Jan Wildenhain; Johnny M Tkach; Abdallah Al-Hakim; Marie-Claude Landry; Cristina Escribano-Diaz; Rachel K Szilard; Jordan T F Young; Meagan Munro; Marella D Canny; Nadine K Kolas; Wei Zhang; Shane M Harding; Jarkko Ylanko; Megan Mendez; Michael Mullin; Thomas Sun; Bianca Habermann; Alessandro Datti; Robert G Bristow; Anne-Claude Gingras; Michael D Tyers; Grant W Brown; Daniel Durocher
The MMS22L-TONSL complex mediates recovery from replication stress and homologous recombination.
Molecular cell 2010;40(4):619-31.
2010: Sumaiya Sharmeen; Marko Skrtic; Mahadeo A Sukhai; Rose Hurren; Marcela Gronda; Xiaoming Wang; Sonali B Fonseca; Hong Sun; Tabitha E Wood; Richard Ward; Mark D Minden; Robert A Batey; Alessandro Datti; Jeffrey L Wrana; Shana O Kelley; Aaron D Schimmer
The antiparasitic agent ivermectin induces chloride-dependent membrane hyperpolarization and cell death in leukemia cells.
Blood 2010;116(18):3593-603.
2010: Kristen M Smith; Alessandro Datti; Mayumi Fujitani; Natalie Grinshtein; Libo Zhang; Olena Morozova; Kim M Blakely; Susan A Rotenberg; Loen M Hansford; Freda D Miller; Herman Yeger; Meredith S Irwin; Jason Moffat; Marco A Marra; Sylvain Baruchel; Jeffrey L Wrana; David R Kaplan
Selective targeting of neuroblastoma tumour-initiating cells by compounds identified in stem cell-based small molecule screens.
EMBO molecular medicine 2010;2(9):371-84.
2010: Payman Samavarchi-Tehrani; Azadeh Golipour; Laurent David; Hoon-Ki Sung; Tobias A Beyer; Alessandro Datti; Knut Woltjen; Andras Nagy; Jeffrey L Wrana
Functional genomics reveals a BMP-driven mesenchymal-to-epithelial transition in the initiation of somatic cell reprogramming.
Cell stem cell 2010;7(1):64-77.
2010: Dea Shahinas; Michael Liang; Alessandro Datti; Dylan R Pillai
A repurposing strategy identifies novel synergistic inhibitors of Plasmodium falciparum heat shock protein 90.
Journal of medicinal chemistry 2010;53(9):3552-7.
2010: Franco Vizeacoumar; Nydia van Dyk; Frederick S Vizeacoumar; Vincent Cheung; Jingjing Li; Yaroslav Sydorskyy; Nicolle Case; Zhijian Li; Alessandro Datti; Corey Nislow; Brian Raught; Zhaolei Zhang; Brendan Frey; Kerry Bloom; Charles Boone; Brenda J Andrews
Integrating high-throughput genetic interaction mapping and high-content screening to explore yeast spindle morphogenesis.
The Journal of cell biology 2010;188(1):69-81.
2009: Yanina Eberhard; Sean McDermott; Xiaoming Wang; Marcela Gronda; Amudha Venugopal; Tabitha E Wood; Rose Hurren; Alessandro Datti; Robert A Batey; Jeffrey L Wrana; William E Antholine; John E Dick; John Dick; Aaron D Schimmer
Chelation of intracellular iron with the antifungal agent ciclopirox olamine induces cell death in leukemia and myeloma cells.
Blood 2009;114(14):3064-73.
2009: Craig D Simpson; Imtiaz A Mawji; Kika Anyiwe; Moyo A Williams; Xiaoming Wang; Amudha L Venugopal; Marcela Gronda; Rose Hurren; Sonia Cheng; Stefano Serra; Reza Beheshti Zavareh; Alessandro Datti; Jeffrey L Wrana; Shereen Ezzat; Aaron D Schimmer
Inhibition of the sodium potassium adenosine triphosphatase pump sensitizes cancer cells to anoikis and prevents distant tumor formation.
Cancer research 2009;69(7):2739-47.
2009: Bryan W Miller; Garnet Lau; Chris Grouios; Emanuela Mollica; Miriam Barrios-Rodiles; Yongmei Liu; Alessandro Datti; Quaid Morris; Jeffrey L Wrana; Liliana Attisano
Application of an integrated physical and functional screening approach to identify inhibitors of the Wnt pathway.
Molecular systems biology 2009;5():315.
2009: Sabata Martino; Ilaria di Girolamo; Antonio Orlacchio; Alessandro Datti; Aldo Orlacchio
MicroRNA implications across neurodevelopment and neuropathology.
Journal of biomedicine & biotechnology 2009;2009():654346.
2009: Sabata Martino; Ilaria di Girolamo; Roberto Tiribuzi; Francesco D'Angelo; Alessandro Datti; Aldo Orlacchio
Efficient siRNA delivery by the cationic liposome DOTAP in human hematopoietic stem cells differentiating into dendritic cells.
Journal of biomedicine & biotechnology 2009;2009():410260.
2008: Ioannis Prassas; Miltiadis Paliouras; Alessandro Datti; Eleftherios P Diamandis
High-throughput screening identifies cardiac glycosides as potent inhibitors of human tissue kallikrein expression: implications for cancer therapies.
Clinical cancer research : an official journal of the American Association for Cancer Research 2008;14(18):5778-84.
2008: Xinliang Mao; Sheng-Ben Liang; Rose Hurren; Marcela Gronda; Sue Chow; G Wei Xu; Xiaoming Wang; Reza Beheshti Zavareh; Nazir Jamal; Hans Messner; David W Hedley; Alessandro Datti; Jeffrey L Wrana; Yuanxiao Zhu; Chang-xin Shi; Kyle Lee; Rodger Tiedemann; Suzanne Trudel; A Keith Stewart; Aaron D Schimmer
Cyproheptadine displays preclinical activity in myeloma and leukemia.
Blood 2008;112(3):760-9.
2008: G Wei Xu; Imtiaz A Mawji; Chloe J Macrae; C Anne Koch; Alessandro Datti; Jeffrey L Wrana; James W Dennis; Aaron D Schimmer
A high-content chemical screen identifies ellipticine as a modulator of p53 nuclear localization.
Apoptosis : an international journal on programmed cell death 2008;13(3):413-22.
2007: Xinliang Mao; A Keith Stewart; Rose Hurren; Alessandro Datti; Xuegong Zhu; Yuanxiao Zhu; Changxin Shi; Kyle Lee; Rodger Tiedemann; Yanina Eberhard; Suzanne Trudel; Shengben Liang; Seth J Corey; Lisa C Gillis; Dwayne Barber; Jeffrey L Wrana; Shereen Ezzat; Aaron D Schimmer
A chemical biology screen identifies glucocorticoids that regulate c-maf expression by increasing its proteasomal degradation through up-regulation of ubiquitin.
Blood 2007;110(12):4047-54.
2007: Richard Mendelsohn; Pam Cheung; Lloyd Berger; Emily A Partridge; Ken Lau; Alessandro Datti; Judy Pawling; James W Dennis
Complex N-glycan and metabolic control in tumor cells.
Cancer research 2007;67(20):9771-80.
2007: Imtiaz A Mawji; Craig D Simpson; Marcela Gronda; Moyo A Williams; Rose Hurren; Clare J Henderson; Alessandro Datti; Jeffrey L Wrana; Aaron D Schimmer
A chemical screen identifies anisomycin as an anoikis sensitizer that functions by decreasing FLIP protein synthesis.
Cancer research 2007;67(17):8307-15.
2006: Bahaedin M Ben-Mahmud; W H Chan; R M Abdulahad; Alessandro Datti; Antonio Orlacchio; Eva M Kohner; Rakesh Chibber
Clinical validation of a link between TNF-alpha and the glycosylation enzyme core 2 GlcNAc-T and the relationship of this link to diabetic retinopathy.
Diabetologia 2006;49(9):2185-91.
2004: Bahaedin M Ben-Mahmud; Giovanni E Mann; Alessandro Datti; Antonio Orlacchio; Eva M Kohner; Rakesh Chibber
Tumor necrosis factor-alpha in diabetic plasma increases the activity of core 2 GlcNAc-T and adherence of human leukocytes to retinal endothelial cells: significance of core 2 GlcNAc-T in diabetic retinopathy.
Diabetes 2004;53(11):2968-76.
2003: Ten-Yang Yen; Bruce A Macher; Steve Bryson; Xiaoqing Chang; Igor Tvaroska; Roderick Tse; Sawako Takeshita; April M Lew; Alessandro Datti
Highly conserved cysteines of mouse core 2 beta1,6-N-acetylglucosaminyltransferase I form a network of disulfide bonds and include a thiol that affects enzyme activity.
The Journal of biological chemistry 2003;278(46):45864-81.
2000: B Korczak; T Le; S Elowe; Alessandro Datti; James W Dennis
Minimal catalytic domain of N-acetylglucosaminyltransferase V.
Glycobiology 2000;10(6):595-9.
2000: Alessandro Datti; R S Donovan; B Korczak; James W Dennis
A homogeneous cell-based assay to identify N-linked carbohydrate processing inhibitors.
Analytical biochemistry 2000;280(1):137-42.
1999: R S Donovan; Alessandro Datti; M G Baek; Q Wu; I J Sas; B Korczak; E G Berger; R Roy; James W Dennis
A solid-phase glycosyltransferase assay for high-throughput screening in drug discovery research.
Glycoconjugate journal 1999;16(10):607-15.
1997: Antonio Orlacchio; Paola Sarchielli; Virgilio Gallai; Alessandro Datti; Carla Saccardi; Carlo A Palmerini
Activity levels of a beta1,6 N-acetylglucosaminyltransferase in lymphomonocytes from multiple sclerosis patients.
Journal of the neurological sciences 1997;151(2):177-83.